Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:E5 6.844116
2R:R:F9 7.14407
3R:R:Y10 6.215117
4R:R:V11 4.8425438
5R:R:V20 6.295436
6R:R:P23 5.685435
7R:R:F24 6.39667635
8R:R:Y30 6.82667634
9R:R:L31 5.735434
10R:R:F37 5.16505
11R:R:L47 5.855417
12R:R:V61 5.424107
13R:R:Q64 5.1065105
14R:R:K67 8.798525
15R:R:Y74 4.755405
16R:R:N78 9.1775489
17R:R:D83 5.6275409
18R:R:F91 7.2275417
19R:R:F103 7.9438
20R:R:I123 7.19587
21R:R:L125 5.8417
22R:R:W126 8.022515
23R:R:V130 3.83487
24R:R:Y136 10.188507
25R:R:R147 6.26524
26R:R:T160 5.095487
27R:R:W161 8.294589
28R:R:P171 8.5125415
29R:R:R177 7.81754115
30R:R:Y178 6.82833613
31R:R:P180 5.312533
32R:R:E181 6.006514
33R:R:M183 5.6625402
34R:R:Q184 6.79533
35R:R:D190 7.7265114
36R:R:Y192 8.2925405
37R:R:T193 4.57754115
38R:R:H195 12.58754114
39R:R:F203 7.452516
40R:R:M207 6.382515
41R:R:H211 7.844516
42R:R:F212 4.74333618
43R:R:P215 3.9419
44R:R:Y223 5.75167619
45R:R:E247 5.595407
46R:R:F261 6.695419
47R:R:Y268 11.7375416
48R:R:S281 6.2354134
49R:R:F283 9.085134
50R:R:K296 6.27517
51R:R:S298 4.82419
52R:R:Y301 4.06415
53R:R:N302 6.158519
54R:R:Y306 7.5619
55R:R:F313 6.5525408
56R:R:C316 5.7254105
57L:L:?1 8.29710
58K:K:F15 8.46754158
59K:K:M182 5.518526
60K:K:E184 6.492526
61K:K:F187 6.415629
62K:K:F190 5.51409
63K:K:R191 9.84159
64K:K:R195 4.91529
65K:K:F198 7.84169
66K:K:E200 7.1325429
67K:K:F202 10.0425426
68K:K:Q205 5.5275409
69K:K:M206 6.15628
70K:K:Y213 7.5325429
71K:K:C215 3.62429
72K:K:K216 6.4775409
73K:K:K217 9.75528
74K:K:R222 9.618529
75K:K:K224 6.692569
76K:K:Y229 9.17568
77K:K:E235 5.6409
78K:K:F246 8.3375409
79K:K:I247 4.2554189
80K:K:Y252 5.33629
81K:K:F254 5.132527
82K:K:E255 4.17407
83K:K:L262 3.975468
84K:K:V263 4.276529
85K:K:N268 7.69458
86K:K:I272 6.008558
87K:K:R273 9.28577
88K:K:H275 6.232559
89K:K:N283 4.154504
90K:K:F286 9.135457
91K:K:R290 10.4967659
92K:K:Y294 6.38857759
93K:K:H306 11.35549
94K:K:I311 3.984546
95K:K:Y312 4.448509
96K:K:R313 6.656549
97K:K:D314 7.242579
98K:K:K316 15.0625479
99K:K:P317 5.305409
100K:K:L322 7.7875459
101K:K:M356 6.306549
102K:K:L360 5.2775448
103K:K:L361 6.098548
104K:K:Y366 4.846549
105K:K:F368 8.854544
106K:K:Y372 6.4448
107K:K:F373 7.9425408
108K:K:Y380 6.72333676
109K:K:E381 6.494579
110K:K:I383 6.154197
111K:K:P388 8.06333679
112K:K:F389 8.3579
113K:K:R390 6.2925477
114K:K:E400 3.815408
115K:K:K402 7.015446
116K:K:V405 5.41408
117K:K:F416 5.91833609
118K:K:F423 6.692595
119K:K:P432 6.2725205
120K:K:L436 4.5225498
121K:K:H449 10.016597
122K:K:L451 5.06495
123K:K:W457 11.675496
124K:K:P471 4.50333659
125K:K:R474 4.3125405
126K:K:Y477 5.426559
127K:K:Q482 7.7556124
128K:K:D483 7.4254128
129K:K:F487 10.27428
130K:K:F495 4.585465
131K:K:D499 8.908569
132K:K:F502 6.864568
133K:K:F506 7.04569
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:M288 R:R:Y192 20.863.59NoYes045
2R:R:M288 R:R:P12 16.48265.03NoNo048
3R:R:P12 R:R:Q184 10.65376.32NoYes383
4R:R:Y191 R:R:Y192 37.487314.89NoYes065
5R:R:Y191 R:R:Y268 38.50315.96NoYes066
6R:R:M183 R:R:T289 12.35046.02YesNo024
7L:L:?1 R:R:Y268 41.485523.39YesYes106
8R:R:L79 R:R:N302 76.65764.12NoYes099
9R:R:N302 R:R:S298 40.58215.96YesYes199
10R:R:C264 R:R:S298 38.04345.16NoYes089
11R:R:C264 R:R:W265 36.998718.28NoNo088
12L:L:?1 R:R:W265 33.57225.3YesNo008
13R:R:F313 R:R:N310 17.54349.67YesNo088
14K:K:E7 R:R:N310 24.47643.94NoNo088
15K:K:E7 R:R:R135 29.03313.49NoNo089
16R:R:R135 R:R:Y306 29.58698.23NoYes199
17R:R:N302 R:R:Y306 30.03253.49YesYes199
18R:R:F313 R:R:I307 10.0195.02YesNo087
19K:K:R222 R:R:K67 52.262917.33YesYes295
20K:K:E200 R:R:K67 1005.4YesYes295
21K:K:E200 K:K:F202 49.65499.33YesYes296
22K:K:D189 K:K:F202 44.904716.72NoYes276
23K:K:D189 R:R:R147 44.784911.91NoYes274
24R:R:L72 R:R:R147 88.2774.86NoYes084
25R:R:F148 R:R:L72 87.876413.4NoNo078
26R:R:F148 R:R:I75 43.79033.77NoNo877
27R:R:I75 R:R:V130 43.39974.61NoYes877
28R:R:T160 R:R:V130 84.24133.17YesYes877
29R:R:S127 R:R:T160 78.84684.8NoYes887
30R:R:L79 R:R:S127 80.26684.5NoNo098
31K:K:E200 K:K:K217 50.53628.1YesYes298
32K:K:E184 K:K:K217 45.20986.75YesYes268
33K:K:E184 R:R:R147 45.15628.14YesYes264
34R:R:E134 R:R:F148 43.790315.16NoNo887
35R:R:E134 R:R:V130 43.39975.7NoYes887
36K:K:R195 R:R:K67 47.16148.66YesYes295
37R:R:T118 R:R:Y178 11.14378.74NoYes043
38R:R:I189 R:R:T118 12.18214.56NoNo044
39L:L:?1 R:R:I189 12.59593.8YesNo104
40R:R:I219 R:R:Y223 57.02754.84NoYes189
41R:R:F261 R:R:I219 56.595313.82YesNo198
42R:R:F212 R:R:F261 54.0153.22YesYes189
43L:L:?1 R:R:F212 51.25823.24YesYes108
44K:K:D23 K:K:R19 23.93685.96NoNo079
45K:K:D23 K:K:R474 23.83668.34NoYes075
46K:K:R474 R:R:Q236 87.67392.34YesNo052
47R:R:A235 R:R:Q236 87.27861.52NoNo042
48R:R:A235 R:R:Q238 87.06631.52NoNo045
49R:R:Q238 R:R:Q244 86.859810.24NoNo054
50R:R:A234 R:R:Q244 86.67714.55NoNo054
51R:R:A234 R:R:E247 86.51816.03NoYes057
52R:R:E247 R:R:K231 85.30295.4YesNo075
53R:R:K231 R:R:V227 85.15613.04NoNo055
54R:R:V227 R:R:V254 84.87554.81NoNo058
55R:R:V254 R:R:Y223 84.74397.57NoYes089
56K:K:M182 K:K:W186 15.44415.82YesNo266
57K:K:C215 K:K:V263 31.81593.42YesYes299
58K:K:C215 K:K:F202 20.22344.19YesYes296
59K:K:C215 K:K:K217 20.25663.23YesYes298
60R:R:M257 R:R:Y223 29.839711.97NoYes089
61K:K:T475 R:R:E239 10.35797.06NoNo062
62K:K:D472 K:K:T475 65.11255.78NoNo086
63K:K:D472 K:K:R474 64.79583.57NoYes085
64R:R:T297 R:R:Y301 14.84134.99NoYes165
65K:K:D324 K:K:R19 21.8375.96NoNo589
66K:K:F487 K:K:R195 46.82073.21YesYes289
67K:K:F487 K:K:R222 48.60024.28YesYes289
68K:K:F487 K:K:R226 93.505925.66YesNo088
69K:K:F198 K:K:R226 91.61757.48YesNo098
70K:K:F198 K:K:L218 89.62397.31YesNo1699
71K:K:K216 K:K:L218 89.17049.87YesNo099
72K:K:E235 K:K:K216 86.74544.05YesYes099
73K:K:F506 K:K:L260 12.25715.83YesNo099
74K:K:F506 K:K:L262 30.12484.87YesYes698
75K:K:E235 K:K:L262 34.78315.3YesYes098
76K:K:F502 K:K:Y229 10.383417.54YesYes688
77K:K:F502 K:K:F506 13.19424.29YesYes689
78K:K:D332 K:K:E235 62.66776.5NoYes099
79K:K:K316 K:K:N319 33.99216.79YesNo099
80K:K:E318 K:K:K316 50.757513.5NoYes099
81K:K:D271 K:K:R273 23.91263.57NoYes097
82K:K:D271 K:K:Y274 23.87413.45NoNo096
83K:K:H275 K:K:Y274 23.72034.36YesNo596
84K:K:H275 K:K:Y477 47.8465.44YesYes599
85K:K:T475 K:K:Y477 72.0187.49NoYes069
86K:K:E318 K:K:P317 41.88084.72NoYes099
87K:K:I272 K:K:P317 59.66263.39YesYes089
88K:K:I272 K:K:L322 42.29938.56YesYes589
89K:K:H275 K:K:L322 22.842714.14YesYes599
90K:K:L322 K:K:P471 46.13964.93YesYes599
91K:K:P471 K:K:Y477 24.84086.95YesYes599
92K:K:D324 K:K:P471 25.43413.22NoYes589
93K:K:H304 K:K:Q307 13.89656.18NoNo084
94K:K:F246 K:K:H304 14.9953.39YesNo098
95K:K:F246 K:K:Q297 19.35648.2YesNo098
96K:K:Q297 K:K:V328 26.35655.73NoNo088
97K:K:V328 K:K:Y294 21.0683.79NoYes089
98K:K:L322 K:K:Y294 26.42353.52YesYes599
99K:K:E381 K:K:P317 17.9257.86YesYes099
100K:K:A291 K:K:M382 10.09864.83NoNo079
101K:K:R447 K:K:W457 10.611533.99NoYes976
102K:K:E303 K:K:R447 11.15958.14NoNo947
103K:K:E303 K:K:Q307 12.26973.82NoNo044
104K:K:F368 K:K:I311 12.05613.77YesYes446
105K:K:I311 K:K:R313 10.36683.76YesYes469
106K:K:L360 K:K:R313 14.71473.64YesYes489
107K:K:L360 K:K:M356 30.71265.65YesYes489
108K:K:G351 K:K:M356 42.06593.49NoYes099
109K:K:D314 K:K:G351 42.74155.03YesNo099
110K:K:D314 K:K:K316 20.751913.83YesYes799
111K:K:I311 K:K:Y366 10.36683.63YesYes469
112K:K:L360 K:K:Y366 14.71475.86YesYes489
113K:K:F355 K:K:R390 13.02657.48NoYes797
114K:K:D314 K:K:L335 24.11836.79YesNo099
115K:K:D332 K:K:L335 27.76239.5NoNo099
116K:K:F373 K:K:R435 10.690910.69YesNo089
117K:K:F373 K:K:F389 13.2385.36YesYes089
118K:K:F389 K:K:P388 24.340615.89YesYes799
119K:K:G387 K:K:P388 33.60174.06NoYes779
120K:K:E381 K:K:G387 21.80616.55YesNo797
121K:K:G387 K:K:R390 12.49967.51NoYes777
122K:K:L361 K:K:M356 10.91727.07YesYes489
123R:R:T297 R:R:Y43 10.14934.99NoNo164
124R:R:N302 R:R:Y301 15.82623.49YesYes195
125R:R:M257 R:R:Y306 29.75099.58NoYes089
126K:K:D332 K:K:N319 34.440312.12NoNo099
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:K296 R:R:M44 4.32 1 Yes No 7 7 1 2
R:R:F91 R:R:L47 6.09 1 Yes Yes 7 7 2 2
R:R:K296 R:R:L47 7.05 1 Yes Yes 7 7 1 2
R:R:F91 R:R:K296 9.93 1 Yes Yes 7 7 2 1
R:R:I189 R:R:T118 4.56 1 No No 4 4 1 2
R:R:L125 R:R:W265 9.11 1 Yes No 7 8 2 1
R:R:C167 R:R:M207 3.24 1 No Yes 5 5 2 1
R:R:E181 R:R:G182 3.27 1 Yes No 4 3 1 2
R:R:E181 R:R:S186 7.19 1 Yes No 4 5 1 2
R:R:E181 R:R:G188 8.19 1 Yes No 4 5 1 2
R:R:E181 R:R:Y268 7.86 1 Yes Yes 4 6 1 1
L:L:?1 R:R:E181 3.52 1 Yes Yes 0 4 0 1
R:R:I189 R:R:M207 4.37 1 No Yes 4 5 1 1
L:L:?1 R:R:I189 3.8 1 Yes No 0 4 0 1
R:R:Y191 R:R:Y268 5.96 0 No Yes 6 6 2 1
R:R:F203 R:R:M207 12.44 1 Yes Yes 6 5 2 1
L:L:?1 R:R:M207 10.34 1 Yes Yes 0 5 0 1
R:R:F212 R:R:I213 3.77 1 Yes No 8 4 1 2
R:R:F212 R:R:L216 3.65 1 Yes No 8 7 1 2
R:R:F212 R:R:F261 3.22 1 Yes Yes 8 9 1 2
R:R:F212 R:R:L266 4.87 1 Yes No 8 6 1 2
R:R:A269 R:R:F212 9.71 0 No Yes 7 8 2 1
L:L:?1 R:R:F212 3.24 1 Yes Yes 0 8 0 1
R:R:F261 R:R:L216 4.87 1 Yes No 9 7 2 2
R:R:C264 R:R:W265 18.28 0 No No 8 8 2 1
L:L:?1 R:R:W265 5.3 1 Yes No 0 8 0 1
R:R:P291 R:R:Y268 9.74 0 No Yes 6 6 2 1
L:L:?1 R:R:Y268 23.39 1 Yes Yes 0 6 0 1
L:L:?1 R:R:K296 8.44 1 Yes Yes 0 7 0 1
R:R:A292 R:R:K296 1.61 0 No Yes 5 7 2 1
R:R:M207 R:R:V204 1.52 1 Yes No 5 4 1 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 7MT9_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 3.17
Number of Linked Nodes 648
Number of Links 801
Number of Hubs 133
Number of Links mediated by Hubs 485
Number of Communities 20
Number of Nodes involved in Communities 208
Number of Links involved in Communities 292
Path Summary
Number Of Nodes in MetaPath 127
Number Of Links MetaPath 126
Number of Shortest Paths 953310
Length Of Smallest Path 3
Average Path Length 26.2322
Length of Longest Path 47
Minimum Path Strength 1.385
Average Path Strength 7.0337
Maximum Path Strength 22.95
Minimum Path Correlation 0.7
Average Path Correlation 0.972095
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 3.44828
Average % Of Corr. Nodes 50.0929
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 50.2284
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• binding   • adenyl ribonucleotide binding   • nucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • adenyl nucleotide binding   • ATP binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • protein serine/threonine kinase activity   • catalytic activity, acting on a protein   • kinase activity   • protein kinase activity   • transferase activity   • G protein-coupled receptor kinase activity   • catalytic activity   • rhodopsin kinase activity   • phosphotransferase activity, alcohol group as acceptor   • transferase activity, transferring phosphorus-containing groups   • cellular response to stimulus   • regulation of biological process   • regulation of signaling   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • regulation of signal transduction   • cell communication   • regulation of response to stimulus   • regulation of cell communication   • cellular process   • signal transduction   • multicellular organismal process
Gene OntologyBiological Process• cellular response to stimulus   • regulation of biological process   • regulation of signaling   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • regulation of signal transduction   • cell communication   • regulation of response to stimulus   • regulation of cell communication   • cellular process   • signal transduction   • multicellular organismal process   • sensory perception of light stimulus   • system process   • sensory perception   • nervous system process   • visual perception   • response to light stimulus   • regulation of response to external stimulus   • regulation of opsin-mediated signaling pathway   • detection of abiotic stimulus   • cellular response to environmental stimulus   • cellular response to light stimulus   • regulation of G protein-coupled receptor signaling pathway   • detection of light stimulus   • phototransduction   • detection of external stimulus   • detection of visible light   • response to external stimulus   • cellular response to radiation   • detection of stimulus   • response to radiation   • response to abiotic stimulus   • G protein-coupled receptor signaling pathway   • cellular response to abiotic stimulus   • G protein-coupled opsin signaling pathway   • phototransduction, visible light   • protein phosphorylation   • protein autophosphorylation   • phosphorylation   • primary metabolic process   • macromolecule modification   • phosphate-containing compound metabolic process   • metabolic process   • protein metabolic process   • macromolecule metabolic process   • protein modification process   • phosphorus metabolic process   • membrane-bounded organelle   • non-motile cilium   • membrane   • 9+0 non-motile cilium   • cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • plasma membrane bounded cell projection   • cell projection   • cellular anatomical structure   • photoreceptor cell cilium   • organelle   • organelle membrane
Gene OntologyCellular Component• membrane-bounded organelle   • non-motile cilium   • membrane   • 9+0 non-motile cilium   • cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • plasma membrane bounded cell projection   • cell projection   • cellular anatomical structure   • photoreceptor cell cilium   • organelle   • organelle membrane   • intracellular anatomical structure   • cytoplasm   • opsin binding   • protein binding   • binding   • arrestin family protein binding   • G protein-coupled photoreceptor activity   • molecular transducer activity   • photoreceptor activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • vitamin binding   • retinal binding   • isoprenoid binding   • retinoid binding   • lipid binding   • 11-cis retinal binding   • small molecule binding   • G-protein alpha-subunit binding   • enzyme regulator activity   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • hydrolase activity   • guanyl ribonucleotide binding   • GDP binding   • purine ribonucleotide binding   • ion binding   • ribonucleoside triphosphate phosphatase activity   • anion binding   • molecular function regulator activity   • heterocyclic compound binding   • carbohydrate derivative binding   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • ribonucleotide binding   • pyrophosphatase activity   • GTPase activity   • nucleoside-triphosphatase regulator activity   • GTPase regulator activity   • purine ribonucleoside triphosphate binding   • guanyl-nucleotide exchange factor activity   • nucleoside phosphate binding   • purine nucleotide binding   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • cation binding   • transition metal ion binding   • zinc ion binding   • metal ion binding   • identical protein binding   • multicellular organismal process   • rod bipolar cell differentiation   • cellular developmental process   • sensory organ development   • retina development in camera-type eye   • visual system development   • neural retina development   • neurogenesis   • multicellular organism development   • eye morphogenesis   • neuron differentiation   • cell differentiation   • anatomical structure development   • animal organ morphogenesis   • sensory system development   • system development   • developmental process   • camera-type eye morphogenesis   • eye development   • animal organ development   • nervous system development   • retinal bipolar neuron differentiation   • glutamatergic neuron differentiation   • generation of neurons   • retina morphogenesis in camera-type eye   • anatomical structure morphogenesis   • sensory organ morphogenesis   • camera-type eye development   • cellular process   • cellular response to stimulus   • response to light stimulus   • response to stimulus   • cellular response to light stimulus   • response to radiation   • response to abiotic stimulus   • cellular response to radiation   • cellular response to abiotic stimulus   • cellular response to environmental stimulus   • regulation of cellular process   • signaling   • detection of abiotic stimulus   • cell communication   • signal transduction   • detection of light stimulus   • phototransduction   • detection of external stimulus   • regulation of biological process   • biological regulation   • detection of visible light   • response to external stimulus   • detection of stimulus   • G protein-coupled receptor signaling pathway   • G protein-coupled opsin signaling pathway   • phototransduction, visible light   • response to light intensity   • podosome assembly   • organelle assembly   • protein-containing complex organization   • membraneless organelle assembly   • cellular component organization   • cellular component biogenesis   • organelle organization   • cellular component assembly   • protein-containing complex assembly   • cellular component organization or biogenesis   • biosynthetic process   • metabolic process   • macromolecule metabolic process   • gene expression   • macromolecule biosynthetic process   • multicellular organismal-level homeostasis   • homeostatic process   • anatomical structure homeostasis   • tissue homeostasis   • retina homeostasis   • photoreceptor cell maintenance   • absorption of visible light   • light absorption   • microtubule cytoskeleton organization   • microtubule-based process   • cytoskeleton organization   • sensory perception of light stimulus   • system process   • sensory perception   • nervous system process   • visual perception   • thermoception   • sensory perception of temperature stimulus   • detection of temperature stimulus involved in sensory perception   • response to temperature stimulus   • detection of temperature stimulus involved in thermoception   • detection of temperature stimulus   • detection of stimulus involved in sensory perception   • taxis   • thermotaxis   • locomotion   • cell-cell junction   • anchoring junction   • cell junction   • cell periphery   • protein-containing complex   • plasma membrane protein complex   • plasma membrane   • plasma membrane signaling receptor complex   • G protein-coupled receptor complex   • membrane protein complex   • receptor complex   • sperm midpiece   • 9+2 motile cilium   • sperm flagellum   • motile cilium   • photoreceptor inner segment membrane   • plasma membrane region   • photoreceptor inner segment   • ciliary membrane   • photoreceptor outer segment membrane   • bounding membrane of organelle   • cell projection membrane   • Golgi membrane   • Golgi apparatus   • intracellular membrane-bounded organelle   • endomembrane system   • intracellular organelle   • outer membrane   • sperm head   • sperm head plasma membrane   • sperm plasma membrane   • rod photoreceptor outer segment
SCOP2Domain Identifier• G protein-coupled receptor-like
SCOP2Family Identifier• G protein-coupled receptor-like
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeRET
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
CodeRET
NameRETINAL
Synonyms
Identifier
FormulaC20 H28 O
Molecular Weight284.436
SMILES
PubChem638015
Formal Charge0
Total Atoms49
Total Chiral Atoms0
Total Bonds49
Total Aromatic Bonds0

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP02699
Sequence
>7MT9_nogp_Chain_R
MNGTEGPNF YVPFSNKTG VVRSPFEAP QYYLAEPWQ FSMLAAYMF 
LLIMLGFPI NFLTLYVTV QHKKLRTPL NYILLNLAV ADLFMVFGG 
FTTTLYTSL HGYFVFGPT GCNLEGFFA TLGGEIALW SLVVLAIER 
YVVVCKPMS NFRFGENHA IMGVAFTWV MALACAAPP LVGWSRYIP 
EGMQCSCGI DYYTPHEET NNESFVIYM FVVHFIIPL IVIFFCYGQ 
LVFTVKEAA AQQQESATT QKAEKEVTR MVIIMVIAF LICWLPYAG 
VAFYIFTHQ GSDFGPIFM TIPAFFAKT SAVYNPVIY IMMNKQFRN 
CMVTTLCCG


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainK
ProteinKinase
UniProtP28327
Sequence
>7MT9_nogp_Chain_K
LETVVANSA FIAARGSFD AMGEDWFLD FRVLGRGGF GEVFACQMK 
ATGKLYACK KLNKKRLKK RKGYQGAMV EKKILAKVH SRFIVSLAY 
AFETKTDLC LVMTIMNGG DIRYHIYNV DEDNPGFQE PRAIFYTAQ 
IVSGLEHLH QRNIIYRDL KPENVLLDD DGNVRISDL GLAVELKAG 
QTKTKGYAG TPGFMAPEL LLGEEYDFS VDYFALGVT LYEMIAARG 
PFRARGEKV ENKELKQRV LEQAVTYPD KFSPASKDF CEALLQKDP 
EKRLGFRDG SCDGLRTHP LFRDISWRQ LEAGMLTPP FVPDSRTVY 
AKNIQDVGA FSTVKGVAF EKADTEFFQ EFAS


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8P15ASensoryOpsinRhodopsinBos taurus--Gi1/β1/γT15.92024-11-20To be published
8P15 (No Gprot) ASensoryOpsinRhodopsinBos taurus--5.92024-11-20To be published
8P13ASensoryOpsinRhodopsinBos taurus--Gi1/β1/γT15.22024-11-20To be published
8P13 (No Gprot) ASensoryOpsinRhodopsinBos taurus--5.22024-11-20To be published
8P12ASensoryOpsinsRhodopsinBos taurus--Gi1/β1/γT13.212024-11-20To be published
8P12 (No Gprot) ASensoryOpsinsRhodopsinBos taurus--3.212024-11-20To be published
9EPRASensoryOpsinsRhodopsinHasarius adansoniRetinal-Gi1/β1/γ24.92024-10-30doi.org/10.1038/s41467-024-53208-2
9EPR (No Gprot) ASensoryOpsinsRhodopsinHasarius adansoniRetinal-4.92024-10-30doi.org/10.1038/s41467-024-53208-2
9EPQASensoryOpsinsRhodopsinHasarius adansoni11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ24.152024-10-2310.1038/s41467-024-53208-2
9EPQ (No Gprot) ASensoryOpsinsRhodopsinHasarius adansoni11,20-Ethanoretinal-4.152024-10-2310.1038/s41467-024-53208-2
9EPPASensoryOpsinsRhodopsinHasarius adansoni11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ24.062024-10-2310.1038/s41467-024-53208-2
9EPP (No Gprot) ASensoryOpsinsRhodopsinHasarius adansoni11,20-Ethanoretinal-4.062024-10-2310.1038/s41467-024-53208-2
8FD1ASensoryOpsinsRhodopsinBos taurus---4.252023-08-3010.1038/s41467-023-40911-9
8FD1 (Multimeric) ASensoryOpsinsRhodopsinBos taurus--4.252023-08-3010.1038/s41467-023-40911-9
8FD0ASensoryOpsinsRhodopsinBos taurus---3.712023-08-3010.1038/s41467-023-40911-9
8FD0 (Multimeric) ASensoryOpsinsRhodopsinBos taurus--3.712023-08-3010.1038/s41467-023-40911-9
8FCZASensoryOpsinsRhodopsinBos taurus11-cis-Retinal--3.72023-08-3010.1038/s41467-023-40911-9
8FCZ (Multimeric) ASensoryOpsinsRhodopsinBos taurus11-cis-Retinal-3.72023-08-3010.1038/s41467-023-40911-9
8A6EASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal--1.82023-03-2910.1038/s41586-023-05863-6
8A6DASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal--1.82023-03-2910.1038/s41586-023-05863-6
8A6CASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal--1.82023-03-2910.1038/s41586-023-05863-6
7ZBEASensoryOpsinsRhodopsinBos taurus11-cis-Retinal--1.82023-03-2910.1038/s41586-023-05863-6
7ZBCASensoryOpsinsRhodopsinBos taurus11-cis-Retinal--1.82023-03-2910.1038/s41586-023-05863-6
7MTBASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal-GRK142021-07-0710.1038/s41586-021-03721-x
7MTB (No Gprot) ASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal-42021-07-0710.1038/s41586-021-03721-x
7MTAASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal-GRK14.12021-07-0710.1038/s41586-021-03721-x
7MTA (No Gprot) ASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal-4.12021-07-0710.1038/s41586-021-03721-x
7MT9ASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal-GRK172021-07-0710.1038/s41586-021-03721-x
7MT9 (No Gprot) ASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal-72021-07-0710.1038/s41586-021-03721-x
7MT8ASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal-GRK15.82021-07-0710.1038/s41586-021-03721-x
7MT8 (No Gprot) ASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal-5.82021-07-0710.1038/s41586-021-03721-x
6PH7ASensoryOpsinsRhodopsinBos taurus-NerolGt(CT)2.92020-07-01To be published
6PH7 (No Gprot) ASensoryOpsinsRhodopsinBos taurus-Nerol2.92020-07-01To be published
6PGSASensoryOpsinsRhodopsinBos taurus-GeraniolGt(CT)2.92020-07-01To be published
6PGS (No Gprot) ASensoryOpsinsRhodopsinBos taurus-Geraniol2.92020-07-01To be published
6PELASensoryOpsinsRhodopsinBos taurus-CitronellolGt(CT)3.192020-06-24To be published
6PEL (No Gprot) ASensoryOpsinsRhodopsinBos taurus-Citronellol3.192020-06-24To be published
6NWEASensoryOpsinsRhodopsinBos taurusOctyl-β-D-Glucopyranoside-Gt(CT)2.712020-02-12To be published
6NWE (No Gprot) ASensoryOpsinsRhodopsinBos taurusOctyl-β-D-Glucopyranoside-2.712020-02-12To be published
6OFJASensoryOpsinsRhodopsinBos taurus---4.52019-08-2110.1074/jbc.RA119.010089
6OFJ (Multimeric) ASensoryOpsinsRhodopsinBos taurus--4.52019-08-2110.1074/jbc.RA119.010089
6OYAASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal-Gt/β1/γ13.32019-07-2410.1016/j.molcel.2019.06.007
6OYA (No Gprot) ASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal-3.32019-07-2410.1016/j.molcel.2019.06.007
6OY9ASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal-Gt/β1/γ13.92019-07-2410.1016/j.molcel.2019.06.007
6OY9 (No Gprot) ASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal-3.92019-07-2410.1016/j.molcel.2019.06.007
6QNOASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal-Gi1/β1/γ14.382019-07-1010.7554/eLife.46041
6QNO (No Gprot) ASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal-4.382019-07-1010.7554/eLife.46041
6I9KASensoryOpsinsRhodopsinHasarius adansoni9-cis-Retinal--2.152019-07-0310.1073/pnas.1902192116
6FUFASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal-Go3.122018-10-0310.1126/sciadv.aat7052
6FUF (No Gprot) ASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal-3.122018-10-0310.1126/sciadv.aat7052
6CMOASensoryOpsinsRhodopsinHomo sapiens--Gi1/β1/γ24.52018-06-2010.1038/s41586-018-0215-y
6CMO (No Gprot) ASensoryOpsinsRhodopsinHomo sapiens--4.52018-06-2010.1038/s41586-018-0215-y
6FKDASensoryOpsinsRhodopsinBos taurus-PubChem 137349183-2.492018-04-0410.1073/pnas.1718084115
6FKCASensoryOpsinsRhodopsinBos taurus-PubChem 132473039-2.462018-04-0410.1073/pnas.1718084115
6FKBASensoryOpsinsRhodopsinBos taurus-PubChem 132473038-3.032018-04-0410.1073/pnas.1718084115
6FKAASensoryOpsinsRhodopsinBos taurus-PubChem 132473037-2.72018-04-0410.1073/pnas.1718084115
6FK9ASensoryOpsinsRhodopsinBos taurus-PubChem 132473036-2.632018-04-0410.1073/pnas.1718084115
6FK8ASensoryOpsinsRhodopsinBos taurus-PubChem 132473035-2.872018-04-0410.1073/pnas.1718084115
6FK7ASensoryOpsinsRhodopsinBos taurus-PubChem 132473034-2.622018-04-0410.1073/pnas.1718084115
6FK6ASensoryOpsinsRhodopsinBos taurus-PubChem 132473033-2.362018-04-0410.1073/pnas.1718084115
5WKTASensoryOpsinsRhodopsinBos taurusOctyl-β-D-Glucopyranoside-Gt(CT)3.22017-12-1310.1038/nprot.2017.135
5WKT (No Gprot) ASensoryOpsinsRhodopsinBos taurusOctyl-β-D-Glucopyranoside-3.22017-12-1310.1038/nprot.2017.135
5W0PASensoryOpsinsRhodopsinHomo sapiens--Arrestin13.012017-08-0910.1016/j.cell.2017.07.002
5TE5ASensoryOpsinsRhodopsinBos taurus20-Methanoretinal--4.012017-03-1510.1073/pnas.1617446114
5TE3ASensoryOpsinsRhodopsinBos taurusOctyl-β-D-Glucopyranoside--2.72017-03-1510.1073/pnas.1617446114
5DYSASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal--2.32016-08-1010.15252/embr.201642671
5EN0ASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal-Gt(CT)2.812016-08-1010.15252/embr.201642671
5EN0 (No Gprot) ASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal-2.812016-08-1010.15252/embr.201642671
5DGYASensoryOpsinsRhodopsinHomo sapiens--Arrestin17.72016-03-2310.1038/sdata.2016.21
4X1HASensoryOpsinsRhodopsinBos taurusNonyl-β-D-Glucopyranoside-Gt(CT)2.292015-11-0410.1016/j.str.2015.09.015
4X1H (No Gprot) ASensoryOpsinsRhodopsinBos taurusNonyl-β-D-Glucopyranoside-2.292015-11-0410.1016/j.str.2015.09.015
4ZWJASensoryOpsinsRhodopsinHomo sapiens--Arrestin13.32015-07-2910.1038/nature14656
4WW3ASensoryOpsinsRhodopsinTodarodes pacificusAll-trans-Retinal--2.82015-06-1710.1371/journal.pone.0126970
4PXFASensoryOpsinsRhodopsinBos taurusOctyl-β-D-Glucopyranoside-Arrestin1 Finger Loop2.752014-09-1710.1038/ncomms5801
4J4QASensoryOpsinsRhodopsinBos taurusOctyl β-D-Glucopyranoside-Gt(CT)2.652013-10-3010.1002/anie.201302374
4J4Q (No Gprot) ASensoryOpsinsRhodopsinBos taurusOctyl β-D-Glucopyranoside-2.652013-10-3010.1002/anie.201302374
4BEYASensoryOpsinsRhodopsinBos taurus--Gt(CT)2.92013-05-0810.1038/embor.2013.44
4BEY (No Gprot) ASensoryOpsinsRhodopsinBos taurus--2.92013-05-0810.1038/embor.2013.44
4BEZASensoryOpsinsRhodopsinBos taurus---3.32013-04-2410.1038/embor.2013.44
4A4MASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal-Gt(CT)3.32012-01-2510.1073/pnas.1114089108
4A4M (No Gprot) ASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal-3.32012-01-2510.1073/pnas.1114089108
3AYNASensoryOpsinsRhodopsinTodarodes pacificus9-cis-Retinal--2.72011-08-1710.1016/j.jmb.2011.08.044
3AYMASensoryOpsinsRhodopsinTodarodes pacificusAll-trans-Retinal--2.82011-08-1710.1016/j.jmb.2011.08.044
2X72ASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal-Gt(CT)32011-03-1610.1038/nature09795
2X72 (No Gprot) ASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal-32011-03-1610.1038/nature09795
3PXOASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal--32011-03-0910.1038/nature09789
3PQRASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal-Gt(CT)2.852011-03-0910.1038/nature09789
3PQR (No Gprot) ASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal-2.852011-03-0910.1038/nature09789
3OAXASensoryOpsinsRhodopsinBos taurus11-cis-Retinal--2.62011-01-1910.1016/j.bpj.2010.08.003
3DQBASensoryOpsinsRhodopsinBos taurus--Gt(CT)3.22008-09-2310.1038/nature07330
3DQB (No Gprot) ASensoryOpsinsRhodopsinBos taurus--3.22008-09-2310.1038/nature07330
3C9MASensoryOpsinsRhodopsinBos taurus11-cis-Retinal--3.42008-08-0510.1107/S0907444908017162
3C9LASensoryOpsinsRhodopsinBos taurus11-cis-Retinal--2.652008-08-0510.1107/S0907444908017162
3CAPASensoryOpsinsRhodopsinBos taurus---2.92008-06-2410.1038/nature07063
3CAP (Multimeric) ASensoryOpsinsRhodopsinBos taurus--2.92008-06-2410.1038/nature07063
2Z73ASensoryOpsinsRhodopsinTodarodes pacificus11-cis-Retinal--2.52008-05-1310.1038/nature06925
2ZIYASensoryOpsinsRhodopsinTodarodes pacificus11-cis-Retinal--3.72008-05-0610.1074/jbc.C800040200
2PEDASensoryOpsinsRhodopsinBos taurus9-cis-Retinal--2.952007-10-3010.1529/biophysj.107.108225
2J4YASensoryOpsinsRhodopsinBos taurus11-cis-Retinal--3.42007-09-2510.1016/j.jmb.2007.03.007
2I37ASensoryOpsinsRhodopsinBos taurus---4.152006-10-1710.1073/pnas.0608022103
2I36ASensoryOpsinsRhodopsinBos taurus---4.12006-10-1710.1073/pnas.0608022103
2I35ASensoryOpsinsRhodopsinBos taurus11-cis-Retinal--3.82006-10-1710.1073/pnas.0608022103
2G87ASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal--2.62006-09-0210.1002/anie.200600595
2HPYASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal--2.82006-08-2210.1073/pnas.0601765103
1U19ASensoryOpsinsRhodopsinBos taurus11-cis-Retinal--2.22004-10-1210.1016/j.jmb.2004.07.044
1GZMASensoryOpsinsRhodopsinBos taurus11-cis-Retinal--2.652003-11-2010.1016/j.jmb.2004.08.090
1L9HASensoryOpsinsRhodopsinBos taurus11-cis-Retinal--2.62002-05-1510.1073/pnas.082666399
1HZXASensoryOpsinsRhodopsinBos taurus11-cis-Retinal--2.82001-07-0410.1021/bi0155091
1F88ASensoryOpsinsRhodopsinBos taurus11-cis-Retinal--2.82000-08-0410.1126/science.289.5480.739




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7MT9_nogp.zip



You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.



You can also  read or  download a guide explaining the meaning of all files and numerical data.