Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:P7 3.315416
2R:R:F9 5.536517
3R:R:Y10 8.99507
4R:R:V11 3.52418
5R:R:P12 4.7625418
6R:R:F13 6.302514
7R:R:N15 4.7417
8R:R:V20 5.856516
9R:R:S22 6.385415
10R:R:P23 5.228515
11R:R:F24 6.47167615
12R:R:Q28 7.678515
13R:R:Y29 5.325414
14R:R:Y30 8.152514
15R:R:L31 8.56414
16R:R:Q36 7.3225412
17R:R:F37 5.914515
18R:R:Y43 9.7925414
19R:R:M44 4.604517
20R:R:L47 8.9925417
21R:R:N55 6.2765139
22R:R:V61 3.1545127
23R:R:H65 7.4875405
24R:R:L68 5.485127
25R:R:N73 5.85754128
26R:R:I75 4.84833617
27R:R:L76 3.52408
28R:R:N78 6.916519
29R:R:D83 6.73754139
30R:R:F91 7.50833617
31R:R:T94 4.1475417
32R:R:F103 5.05143718
33R:R:C110 4.8575419
34R:R:E113 4.58714715
35R:R:F115 3.7475416
36R:R:E122 6.01416
37R:R:I123 3.99617
38R:R:L125 7.7925417
39R:R:W126 7.15714715
40R:R:V129 4.2925417
41R:R:V130 3.61517
42R:R:E134 7.7418
43R:R:R135 7.654579
44R:R:Y136 6.80754147
45R:R:V139 2.3425408
46R:R:N145 5.52465
47R:R:F146 6.134515
48R:R:R147 7.21143754
49R:R:F148 5.604517
50R:R:E150 3.9625412
51R:R:T160 3.925417
52R:R:W161 7.0425419
53R:R:P170 4.0225417
54R:R:P171 6.91415
55R:R:W175 8.088515
56R:R:R177 12.86415
57R:R:Y178 6.805613
58R:R:I179 5.735411
59R:R:P180 5.04167613
60R:R:E181 4.91504
61R:R:M183 4.722512
62R:R:Q184 6.532513
63R:R:C187 5.8419
64R:R:D190 11.27414
65R:R:Y191 8.0725416
66R:R:Y192 9.11505
67R:R:T193 6.648515
68R:R:P194 6.4525411
69R:R:H195 7.512514
70R:R:F203 9.02616
71R:R:Y206 5.624514
72R:R:M207 7415
73R:R:H211 7.53833616
74R:R:F212 4.978508
75R:R:P215 4.51519
76R:R:Y223 7.2375479
77R:R:V227 2.81405
78R:R:T243 3.655405
79R:R:V250 4.40754158
80R:R:M257 7.6675478
81R:R:F261 5.572509
82R:R:W265 10.63508
83R:R:Y268 9.474516
84R:R:F283 6.1654164
85R:R:P285 4.6375413
86R:R:F294 4.67407
87R:R:K296 6.715417
88R:R:Y301 4.71575
89R:R:N302 6.878579
90R:R:Y306 7.615679
91R:R:F313 6.6385128
92L:L:?1 8.68286710
93K:K:F15 9.566568
94K:K:R19 6.0625489
95K:K:D23 4.7275487
96K:K:F187 6.41333659
97K:K:L188 4.95467
98K:K:F190 5.36669
99K:K:R191 7.12669
100K:K:V192 6.5575457
101K:K:R195 4.45109
102K:K:F202 9.488556
103K:K:Q205 5.03667669
104K:K:M206 6.196558
105K:K:K211 11.89408
106K:K:L212 5.6725408
107K:K:C215 4.555459
108K:K:K216 4.4175409
109K:K:L218 5.01439
110K:K:R222 8.31754109
111K:K:K224 5.058539
112K:K:Y229 9.804538
113K:K:E235 6.5475409
114K:K:K236 5.435439
115K:K:I238 3.96407
116K:K:V242 4.05547
117K:K:R245 8.815407
118K:K:F246 8.34549
119K:K:I247 4.035409
120K:K:F254 6.518557
121K:K:K257 4.855617
122K:K:D259 7.83405
123K:K:L260 7.032539
124K:K:C261 6.265458
125K:K:L262 4.275438
126K:K:V263 4.034559
127K:K:M267 5.464119
128K:K:N268 5.065488
129K:K:I272 4.266598
130K:K:R273 9.448527
131K:K:Y274 6.11754176
132K:K:Y277 6.422527
133K:K:N283 4.7275404
134K:K:F286 8.6497
135K:K:R290 13.19499
136K:K:F293 7.1225408
137K:K:Y294 6.20667699
138K:K:Q297 9.2325408
139K:K:H304 3.944548
140K:K:R308 4.085444
141K:K:I310 5.91448
142K:K:I311 4.2625426
143K:K:Y312 4.424509
144K:K:R313 6.8575429
145K:K:L315 3.461676187
146K:K:K316 8.254529
147K:K:P317 3.995629
148K:K:L322 6.6625409
149K:K:D323 6.93254119
150K:K:N327 5.7165118
151K:K:V328 6.5575498
152K:K:R329 4.744119
153K:K:L333 4.31509
154K:K:E338 8.565444
155K:K:P353 4.975406
156K:K:F355 5.494529
157K:K:M356 6.112529
158K:K:P358 3.985429
159K:K:E359 7.09429
160K:K:L361 6.9375428
161K:K:Y366 7.15571729
162K:K:S369 5.08428
163K:K:V370 3.55627
164K:K:D371 5.1975409
165K:K:Y372 6.85833608
166K:K:F373 5.29833628
167K:K:L375 3.9365188
168K:K:V377 4.648529
169K:K:Y380 5.32726
170K:K:E381 7.228529
171K:K:M382 3.625499
172K:K:I383 5.436527
173K:K:G387 3.3075427
174K:K:P388 8.06333629
175K:K:F389 5.94833629
176K:K:R390 4.6975427
177K:K:L401 4.2775407
178K:K:V405 3.965428
179K:K:L406 3.2425404
180K:K:V410 5.8425427
181K:K:Y412 6.432527
182K:K:F416 6.47286729
183K:K:F423 9.006545
184K:K:L427 5.07407
185K:K:L428 4.885428
186K:K:R435 5.745429
187K:K:R447 12.035197
188K:K:L451 4.24445
189K:K:F452 7.56448
190K:K:L460 4.0525448
191K:K:P467 3.835406
192K:K:P471 4.452509
193K:K:R474 9.97485
194K:K:V476 4.5525468
195K:K:Y477 5.4456179
196K:K:I481 5.322557
197K:K:E489 8.09254107
198K:K:E496 5.7025437
199K:K:D499 8.622539
200K:K:F502 5.42538
201K:K:F503 9.66537
202K:K:F506 8.266539
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:Y10 R:R:Y192 11.177615.89YesYes075
2R:R:M44 R:R:T94 21.84916.02YesYes177
3R:R:M44 R:R:Y43 19.80334.79YesYes174
4R:R:Y191 R:R:Y192 26.608317.87YesYes065
5L:L:?1 R:R:Y191 26.98573.12YesYes106
6R:R:T297 R:R:Y43 21.13944.99NoYes064
7L:L:?1 R:R:W265 36.52966.82YesYes008
8R:R:F159 R:R:W126 12.13024.01NoYes135
9R:R:F159 R:R:V130 17.56262.62NoYes137
10R:R:C264 R:R:W265 36.267618.28NoYes088
11R:R:C264 R:R:S298 36.51376.89NoNo089
12R:R:N302 R:R:S298 36.69277.45YesNo799
13R:R:N302 R:R:Y306 68.02025.81YesYes799
14R:R:R135 R:R:Y306 33.52284.12YesYes799
15K:K:F506 K:K:L262 14.20886.09YesYes398
16K:K:L250 K:K:L262 18.0845.54NoYes098
17K:K:L239 K:K:L250 18.4884.15NoNo099
18K:K:L239 K:K:L333 18.68944.15NoYes099
19K:K:L333 K:K:Y312 19.48495.86YesYes099
20K:K:L315 K:K:Y312 21.31753.52YesYes079
21K:K:L315 K:K:T378 23.47895.9YesNo078
22K:K:P317 K:K:T378 23.6086.99YesNo098
23K:K:P317 K:K:R273 33.69922.88YesYes297
24K:K:D271 K:K:R273 41.67163.57NoYes097
25K:K:D271 K:K:Y274 41.78173.45NoYes096
26K:K:Y274 K:K:Y477 41.8824.96YesYes1769
27K:K:T475 K:K:Y477 99.96492.5NoYes069
28K:K:D472 K:K:T475 1004.34NoNo086
29K:K:D472 K:K:R474 99.91427.15NoYes885
30K:K:R474 R:R:Q237 72.899519.86YesNo055
31R:R:Q237 R:R:T243 70.87755.67NoYes055
32R:R:A234 R:R:T243 70.50381.68NoYes055
33R:R:A234 R:R:E247 70.46647.54NoNo057
34R:R:E247 R:R:K231 70.44435.4NoNo075
35R:R:K231 R:R:V227 70.45893.04NoYes055
36R:R:V227 R:R:V250 70.54471.6YesYes058
37R:R:V250 R:R:V254 72.94331.6YesNo088
38R:R:V254 R:R:Y223 72.92533.79NoYes089
39R:R:R135 R:R:Y223 38.42814.12YesYes799
40R:R:M257 R:R:Y223 34.443214.37YesYes789
41R:R:M257 R:R:Y306 33.30847.18YesYes789
42R:R:E134 R:R:V130 16.29724.28YesYes187
43R:R:E134 R:R:F148 20.635811.66YesYes187
44R:R:F148 R:R:H152 16.75113.39YesNo175
45R:R:F146 R:R:H152 13.72789.05YesNo155
46K:K:D185 R:R:F146 14.84237.17NoYes155
47K:K:D185 K:K:K207 15.04926.91NoNo058
48K:K:K207 R:R:N145 14.71064.2NoYes085
49K:K:Q205 R:R:N145 14.06837.92YesYes695
50K:K:T256 R:R:R147 10.24983.88NoYes084
51K:K:L212 K:K:Q205 14.34235.32YesYes089
52K:K:D23 K:K:R19 27.523310.72YesYes879
53K:K:N268 K:K:R19 27.59733.62YesYes889
54K:K:L212 K:K:N268 13.98052.75YesYes088
55K:K:D23 K:K:R474 27.92293.57YesYes875
56K:K:K211 K:K:Y213 12.577921.5YesNo089
57K:K:V263 K:K:Y213 10.4923.79YesNo099
58K:K:I266 K:K:N268 14.08638.5NoYes078
59K:K:F246 K:K:H304 12.66423.39YesYes498
60K:K:G326 K:K:P467 13.30484.06NoYes096
61K:K:G326 K:K:P471 13.38984.06NoYes099
62K:K:P471 K:K:Y477 39.084.17YesYes099
63K:K:F246 K:K:Q297 13.4398.2YesYes098
64K:K:Q297 K:K:V328 10.66825.73YesYes088
65K:K:I272 K:K:L322 27.0995.71YesYes089
66K:K:L322 K:K:P471 19.3613.28YesYes099
67K:K:L322 K:K:Y294 11.36183.52YesYes099
68K:K:H275 K:K:L322 19.370714.14NoYes099
69K:K:H275 K:K:Y477 19.353715.24NoYes1799
70K:K:I272 K:K:V320 16.01264.61YesNo989
71K:K:M382 K:K:Y294 10.44953.59YesYes999
72K:K:K415 K:K:P284 10.05736.69NoNo045
73K:K:I383 K:K:K415 11.87592.91YesNo074
74K:K:I383 K:K:L379 14.19742.85YesNo076
75K:K:L379 K:K:T295 16.19038.84NoNo067
76K:K:M382 K:K:T295 16.92663.01YesNo097
77K:K:L375 K:K:L427 10.09795.54YesYes087
78K:K:I298 K:K:L375 16.02512.85NoYes078
79K:K:I298 K:K:V320 16.29076.14NoNo079
80R:R:E113 R:R:T94 11.74282.82YesYes157
81R:R:T297 R:R:Y301 21.42946.24NoYes065
82R:R:N302 R:R:Y301 25.08254.65YesYes795
83K:K:I266 K:K:K211 13.865211.63NoYes078
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F91 R:R:L47 14.61 1 Yes Yes 7 7 2 2
R:R:K296 R:R:L47 5.64 1 Yes Yes 7 7 1 2
R:R:F91 R:R:K296 11.17 1 Yes Yes 7 7 2 1
R:R:I189 R:R:T118 4.56 1 No No 4 4 1 2
R:R:G121 R:R:W265 2.81 0 No Yes 7 8 2 1
R:R:L125 R:R:W265 18.22 1 Yes Yes 7 8 2 1
R:R:C167 R:R:M207 3.24 1 No Yes 5 5 2 1
R:R:E181 R:R:Y192 3.37 0 Yes Yes 4 5 2 2
R:R:E181 R:R:Y268 5.61 0 Yes Yes 4 6 2 1
R:R:I189 R:R:M207 2.92 1 No Yes 4 5 1 1
L:L:?1 R:R:I189 4.75 1 Yes No 0 4 0 1
R:R:Y191 R:R:Y192 17.87 1 Yes Yes 6 5 1 2
R:R:Y191 R:R:Y268 5.96 1 Yes Yes 6 6 1 1
R:R:A272 R:R:Y191 5.34 0 No Yes 5 6 2 1
L:L:?1 R:R:Y191 3.12 1 Yes Yes 0 6 0 1
R:R:F203 R:R:M207 12.44 1 Yes Yes 6 5 2 1
L:L:?1 R:R:M207 9.4 1 Yes Yes 0 5 0 1
R:R:F212 R:R:I213 3.77 0 Yes No 8 4 1 2
R:R:F212 R:R:F261 4.29 0 Yes Yes 8 9 1 2
R:R:F212 R:R:L266 3.65 0 Yes No 8 6 1 2
R:R:A269 R:R:F212 8.32 0 No Yes 7 8 2 1
L:L:?1 R:R:F212 4.86 1 Yes Yes 0 8 0 1
R:R:F261 R:R:W265 7.02 0 Yes Yes 9 8 2 1
R:R:C264 R:R:W265 18.28 0 No Yes 8 8 2 1
L:L:?1 R:R:W265 6.82 1 Yes Yes 0 8 0 1
R:R:P291 R:R:Y268 9.74 0 No Yes 6 6 2 1
R:R:A295 R:R:Y268 2.67 0 No Yes 8 6 2 1
L:L:?1 R:R:Y268 23.39 1 Yes Yes 0 6 0 1
L:L:?1 R:R:K296 8.44 1 Yes Yes 0 7 0 1
R:R:A292 R:R:K296 1.61 0 No Yes 5 7 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 7MTA_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 2.62
Number of Linked Nodes 649
Number of Links 905
Number of Hubs 202
Number of Links mediated by Hubs 673
Number of Communities 19
Number of Nodes involved in Communities 261
Number of Links involved in Communities 406
Path Summary
Number Of Nodes in MetaPath 84
Number Of Links MetaPath 83
Number of Shortest Paths 823020
Length Of Smallest Path 3
Average Path Length 24.4882
Length of Longest Path 51
Minimum Path Strength 1.27
Average Path Strength 5.97148
Maximum Path Strength 20.31
Minimum Path Correlation 0.7
Average Path Correlation 0.964809
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.5641
Average % Of Corr. Nodes 46.9397
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 60.9144
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• binding   • adenyl ribonucleotide binding   • nucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • adenyl nucleotide binding   • ATP binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • protein serine/threonine kinase activity   • catalytic activity, acting on a protein   • kinase activity   • protein kinase activity   • transferase activity   • G protein-coupled receptor kinase activity   • catalytic activity   • rhodopsin kinase activity   • phosphotransferase activity, alcohol group as acceptor   • transferase activity, transferring phosphorus-containing groups   • cellular response to stimulus   • regulation of biological process   • regulation of signaling   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • regulation of signal transduction   • cell communication   • regulation of response to stimulus   • regulation of cell communication   • cellular process   • signal transduction   • multicellular organismal process
Gene OntologyBiological Process• cellular response to stimulus   • regulation of biological process   • regulation of signaling   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • regulation of signal transduction   • cell communication   • regulation of response to stimulus   • regulation of cell communication   • cellular process   • signal transduction   • multicellular organismal process   • sensory perception of light stimulus   • system process   • sensory perception   • nervous system process   • visual perception   • response to light stimulus   • regulation of response to external stimulus   • regulation of opsin-mediated signaling pathway   • detection of abiotic stimulus   • cellular response to environmental stimulus   • cellular response to light stimulus   • regulation of G protein-coupled receptor signaling pathway   • detection of light stimulus   • phototransduction   • detection of external stimulus   • detection of visible light   • response to external stimulus   • cellular response to radiation   • detection of stimulus   • response to radiation   • response to abiotic stimulus   • G protein-coupled receptor signaling pathway   • cellular response to abiotic stimulus   • G protein-coupled opsin signaling pathway   • phototransduction, visible light   • protein phosphorylation   • protein autophosphorylation   • phosphorylation   • primary metabolic process   • macromolecule modification   • phosphate-containing compound metabolic process   • metabolic process   • protein metabolic process   • macromolecule metabolic process   • protein modification process   • phosphorus metabolic process   • membrane-bounded organelle   • non-motile cilium   • membrane   • 9+0 non-motile cilium   • cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • plasma membrane bounded cell projection   • cell projection   • cellular anatomical structure   • photoreceptor cell cilium   • organelle   • organelle membrane
Gene OntologyCellular Component• membrane-bounded organelle   • non-motile cilium   • membrane   • 9+0 non-motile cilium   • cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • plasma membrane bounded cell projection   • cell projection   • cellular anatomical structure   • photoreceptor cell cilium   • organelle   • organelle membrane   • intracellular anatomical structure   • cytoplasm   • opsin binding   • protein binding   • binding   • arrestin family protein binding   • G protein-coupled photoreceptor activity   • molecular transducer activity   • photoreceptor activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • vitamin binding   • retinal binding   • isoprenoid binding   • retinoid binding   • lipid binding   • 11-cis retinal binding   • small molecule binding   • G-protein alpha-subunit binding   • enzyme regulator activity   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • hydrolase activity   • guanyl ribonucleotide binding   • GDP binding   • purine ribonucleotide binding   • ion binding   • ribonucleoside triphosphate phosphatase activity   • anion binding   • molecular function regulator activity   • heterocyclic compound binding   • carbohydrate derivative binding   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • ribonucleotide binding   • pyrophosphatase activity   • GTPase activity   • nucleoside-triphosphatase regulator activity   • GTPase regulator activity   • purine ribonucleoside triphosphate binding   • guanyl-nucleotide exchange factor activity   • nucleoside phosphate binding   • purine nucleotide binding   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • cation binding   • transition metal ion binding   • zinc ion binding   • metal ion binding   • identical protein binding   • multicellular organismal process   • rod bipolar cell differentiation   • cellular developmental process   • sensory organ development   • retina development in camera-type eye   • visual system development   • neural retina development   • neurogenesis   • multicellular organism development   • eye morphogenesis   • neuron differentiation   • cell differentiation   • anatomical structure development   • animal organ morphogenesis   • sensory system development   • system development   • developmental process   • camera-type eye morphogenesis   • eye development   • animal organ development   • nervous system development   • retinal bipolar neuron differentiation   • glutamatergic neuron differentiation   • generation of neurons   • retina morphogenesis in camera-type eye   • anatomical structure morphogenesis   • sensory organ morphogenesis   • camera-type eye development   • cellular process   • cellular response to stimulus   • response to light stimulus   • response to stimulus   • cellular response to light stimulus   • response to radiation   • response to abiotic stimulus   • cellular response to radiation   • cellular response to abiotic stimulus   • cellular response to environmental stimulus   • regulation of cellular process   • signaling   • detection of abiotic stimulus   • cell communication   • signal transduction   • detection of light stimulus   • phototransduction   • detection of external stimulus   • regulation of biological process   • biological regulation   • detection of visible light   • response to external stimulus   • detection of stimulus   • G protein-coupled receptor signaling pathway   • G protein-coupled opsin signaling pathway   • phototransduction, visible light   • response to light intensity   • podosome assembly   • organelle assembly   • protein-containing complex organization   • membraneless organelle assembly   • cellular component organization   • cellular component biogenesis   • organelle organization   • cellular component assembly   • protein-containing complex assembly   • cellular component organization or biogenesis   • biosynthetic process   • metabolic process   • macromolecule metabolic process   • gene expression   • macromolecule biosynthetic process   • multicellular organismal-level homeostasis   • homeostatic process   • anatomical structure homeostasis   • tissue homeostasis   • retina homeostasis   • photoreceptor cell maintenance   • absorption of visible light   • light absorption   • microtubule cytoskeleton organization   • microtubule-based process   • cytoskeleton organization   • sensory perception of light stimulus   • system process   • sensory perception   • nervous system process   • visual perception   • thermoception   • sensory perception of temperature stimulus   • detection of temperature stimulus involved in sensory perception   • response to temperature stimulus   • detection of temperature stimulus involved in thermoception   • detection of temperature stimulus   • detection of stimulus involved in sensory perception   • taxis   • thermotaxis   • locomotion   • cell-cell junction   • anchoring junction   • cell junction   • cell periphery   • protein-containing complex   • plasma membrane protein complex   • plasma membrane   • plasma membrane signaling receptor complex   • G protein-coupled receptor complex   • membrane protein complex   • receptor complex   • sperm midpiece   • 9+2 motile cilium   • sperm flagellum   • motile cilium   • photoreceptor inner segment membrane   • plasma membrane region   • photoreceptor inner segment   • ciliary membrane   • photoreceptor outer segment membrane   • bounding membrane of organelle   • cell projection membrane   • Golgi membrane   • Golgi apparatus   • intracellular membrane-bounded organelle   • endomembrane system   • intracellular organelle   • outer membrane   • sperm head   • sperm head plasma membrane   • sperm plasma membrane   • rod photoreceptor outer segment
SCOP2Domain Identifier• G protein-coupled receptor-like
SCOP2Family Identifier• G protein-coupled receptor-like
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeRET
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
CodeRET
NameRETINAL
Synonyms
Identifier
FormulaC20 H28 O
Molecular Weight284.436
SMILES
PubChem638015
Formal Charge0
Total Atoms49
Total Chiral Atoms0
Total Bonds49
Total Aromatic Bonds0

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP02699
Sequence
>7MTA_nogp_Chain_R
MNGTEGPNF YVPFSNKTG VVRSPFEAP QYYLAEPWQ FSMLAAYMF 
LLIMLGFPI NFLTLYVTV QHKKLRTPL NYILLNLAV ADLFMVFGG 
FTTTLYTSL HGYFVFGPT GCNLEGFFA TLGGEIALW SLVVLAIER 
YVVVCKPMS NFRFGENHA IMGVAFTWV MALACAAPP LVGWSRYIP 
EGMQCSCGI DYYTPHEET NNESFVIYM FVVHFIIPL IVIFFCYGQ 
LVFTVKEAA AQQQESATT QKAEKEVTR MVIIMVIAF LICWLPYAG 
VAFYIFTHQ GSDFGPIFM TIPAFFAKT SAVYNPVIY IMMNKQFRN 
CMVTTLCCG


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainK
ProteinKinase
UniProtP28327
Sequence
>7MTA_nogp_Chain_K
LETVVANSA FIAARGSFD AMGEDWFLD FRVLGRGGF GEVFACQMK 
ATGKLYACK KLNKKRLKK RKGYQGAMV EKKILAKVH SRFIVSLAY 
AFETKTDLC LVMTIMNGG DIRYHIYNV DEDNPGFQE PRAIFYTAQ 
IVSGLEHLH QRNIIYRDL KPENVLLDD DGNVRISDL GLAVELKAG 
QTKTKGYAG TPGFMAPEL LLGEEYDFS VDYFALGVT LYEMIAARG 
PFRARGEKV ENKELKQRV LEQAVTYPD KFSPASKDF CEALLQKDP 
EKRLGFRDG SCDGLRTHP LFRDISWRQ LEAGMLTPP FVPDSRTVY 
AKNIQDVGA FEEVKGVAF EKADTEFFQ EFAS


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8P15ASensoryOpsinRhodopsinBos taurus--Gi1/β1/γT15.92024-11-20To be published
8P15 (No Gprot) ASensoryOpsinRhodopsinBos taurus--5.92024-11-20To be published
8P13ASensoryOpsinRhodopsinBos taurus--Gi1/β1/γT15.22024-11-20To be published
8P13 (No Gprot) ASensoryOpsinRhodopsinBos taurus--5.22024-11-20To be published
8P12ASensoryOpsinsRhodopsinBos taurus--Gi1/β1/γT13.212024-11-20To be published
8P12 (No Gprot) ASensoryOpsinsRhodopsinBos taurus--3.212024-11-20To be published
9EPRASensoryOpsinsRhodopsinHasarius adansoniRetinal-Gi1/β1/γ24.92024-10-30doi.org/10.1038/s41467-024-53208-2
9EPR (No Gprot) ASensoryOpsinsRhodopsinHasarius adansoniRetinal-4.92024-10-30doi.org/10.1038/s41467-024-53208-2
9EPQASensoryOpsinsRhodopsinHasarius adansoni11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ24.152024-10-2310.1038/s41467-024-53208-2
9EPQ (No Gprot) ASensoryOpsinsRhodopsinHasarius adansoni11,20-Ethanoretinal-4.152024-10-2310.1038/s41467-024-53208-2
9EPPASensoryOpsinsRhodopsinHasarius adansoni11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ24.062024-10-2310.1038/s41467-024-53208-2
9EPP (No Gprot) ASensoryOpsinsRhodopsinHasarius adansoni11,20-Ethanoretinal-4.062024-10-2310.1038/s41467-024-53208-2
8FD1ASensoryOpsinsRhodopsinBos taurus---4.252023-08-3010.1038/s41467-023-40911-9
8FD1 (Multimeric) ASensoryOpsinsRhodopsinBos taurus--4.252023-08-3010.1038/s41467-023-40911-9
8FD0ASensoryOpsinsRhodopsinBos taurus---3.712023-08-3010.1038/s41467-023-40911-9
8FD0 (Multimeric) ASensoryOpsinsRhodopsinBos taurus--3.712023-08-3010.1038/s41467-023-40911-9
8FCZASensoryOpsinsRhodopsinBos taurus11-cis-Retinal--3.72023-08-3010.1038/s41467-023-40911-9
8FCZ (Multimeric) ASensoryOpsinsRhodopsinBos taurus11-cis-Retinal-3.72023-08-3010.1038/s41467-023-40911-9
8A6EASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal--1.82023-03-2910.1038/s41586-023-05863-6
8A6DASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal--1.82023-03-2910.1038/s41586-023-05863-6
8A6CASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal--1.82023-03-2910.1038/s41586-023-05863-6
7ZBEASensoryOpsinsRhodopsinBos taurus11-cis-Retinal--1.82023-03-2910.1038/s41586-023-05863-6
7ZBCASensoryOpsinsRhodopsinBos taurus11-cis-Retinal--1.82023-03-2910.1038/s41586-023-05863-6
7MTBASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal-GRK142021-07-0710.1038/s41586-021-03721-x
7MTB (No Gprot) ASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal-42021-07-0710.1038/s41586-021-03721-x
7MTAASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal-GRK14.12021-07-0710.1038/s41586-021-03721-x
7MTA (No Gprot) ASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal-4.12021-07-0710.1038/s41586-021-03721-x
7MT9ASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal-GRK172021-07-0710.1038/s41586-021-03721-x
7MT9 (No Gprot) ASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal-72021-07-0710.1038/s41586-021-03721-x
7MT8ASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal-GRK15.82021-07-0710.1038/s41586-021-03721-x
7MT8 (No Gprot) ASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal-5.82021-07-0710.1038/s41586-021-03721-x
6PH7ASensoryOpsinsRhodopsinBos taurus-NerolGt(CT)2.92020-07-01To be published
6PH7 (No Gprot) ASensoryOpsinsRhodopsinBos taurus-Nerol2.92020-07-01To be published
6PGSASensoryOpsinsRhodopsinBos taurus-GeraniolGt(CT)2.92020-07-01To be published
6PGS (No Gprot) ASensoryOpsinsRhodopsinBos taurus-Geraniol2.92020-07-01To be published
6PELASensoryOpsinsRhodopsinBos taurus-CitronellolGt(CT)3.192020-06-24To be published
6PEL (No Gprot) ASensoryOpsinsRhodopsinBos taurus-Citronellol3.192020-06-24To be published
6NWEASensoryOpsinsRhodopsinBos taurusOctyl-β-D-Glucopyranoside-Gt(CT)2.712020-02-12To be published
6NWE (No Gprot) ASensoryOpsinsRhodopsinBos taurusOctyl-β-D-Glucopyranoside-2.712020-02-12To be published
6OFJASensoryOpsinsRhodopsinBos taurus---4.52019-08-2110.1074/jbc.RA119.010089
6OFJ (Multimeric) ASensoryOpsinsRhodopsinBos taurus--4.52019-08-2110.1074/jbc.RA119.010089
6OYAASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal-Gt/β1/γ13.32019-07-2410.1016/j.molcel.2019.06.007
6OYA (No Gprot) ASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal-3.32019-07-2410.1016/j.molcel.2019.06.007
6OY9ASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal-Gt/β1/γ13.92019-07-2410.1016/j.molcel.2019.06.007
6OY9 (No Gprot) ASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal-3.92019-07-2410.1016/j.molcel.2019.06.007
6QNOASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal-Gi1/β1/γ14.382019-07-1010.7554/eLife.46041
6QNO (No Gprot) ASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal-4.382019-07-1010.7554/eLife.46041
6I9KASensoryOpsinsRhodopsinHasarius adansoni9-cis-Retinal--2.152019-07-0310.1073/pnas.1902192116
6FUFASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal-Go3.122018-10-0310.1126/sciadv.aat7052
6FUF (No Gprot) ASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal-3.122018-10-0310.1126/sciadv.aat7052
6CMOASensoryOpsinsRhodopsinHomo sapiens--Gi1/β1/γ24.52018-06-2010.1038/s41586-018-0215-y
6CMO (No Gprot) ASensoryOpsinsRhodopsinHomo sapiens--4.52018-06-2010.1038/s41586-018-0215-y
6FKDASensoryOpsinsRhodopsinBos taurus-PubChem 137349183-2.492018-04-0410.1073/pnas.1718084115
6FKCASensoryOpsinsRhodopsinBos taurus-PubChem 132473039-2.462018-04-0410.1073/pnas.1718084115
6FKBASensoryOpsinsRhodopsinBos taurus-PubChem 132473038-3.032018-04-0410.1073/pnas.1718084115
6FKAASensoryOpsinsRhodopsinBos taurus-PubChem 132473037-2.72018-04-0410.1073/pnas.1718084115
6FK9ASensoryOpsinsRhodopsinBos taurus-PubChem 132473036-2.632018-04-0410.1073/pnas.1718084115
6FK8ASensoryOpsinsRhodopsinBos taurus-PubChem 132473035-2.872018-04-0410.1073/pnas.1718084115
6FK7ASensoryOpsinsRhodopsinBos taurus-PubChem 132473034-2.622018-04-0410.1073/pnas.1718084115
6FK6ASensoryOpsinsRhodopsinBos taurus-PubChem 132473033-2.362018-04-0410.1073/pnas.1718084115
5WKTASensoryOpsinsRhodopsinBos taurusOctyl-β-D-Glucopyranoside-Gt(CT)3.22017-12-1310.1038/nprot.2017.135
5WKT (No Gprot) ASensoryOpsinsRhodopsinBos taurusOctyl-β-D-Glucopyranoside-3.22017-12-1310.1038/nprot.2017.135
5W0PASensoryOpsinsRhodopsinHomo sapiens--Arrestin13.012017-08-0910.1016/j.cell.2017.07.002
5TE5ASensoryOpsinsRhodopsinBos taurus20-Methanoretinal--4.012017-03-1510.1073/pnas.1617446114
5TE3ASensoryOpsinsRhodopsinBos taurusOctyl-β-D-Glucopyranoside--2.72017-03-1510.1073/pnas.1617446114
5DYSASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal--2.32016-08-1010.15252/embr.201642671
5EN0ASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal-Gt(CT)2.812016-08-1010.15252/embr.201642671
5EN0 (No Gprot) ASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal-2.812016-08-1010.15252/embr.201642671
5DGYASensoryOpsinsRhodopsinHomo sapiens--Arrestin17.72016-03-2310.1038/sdata.2016.21
4X1HASensoryOpsinsRhodopsinBos taurusNonyl-β-D-Glucopyranoside-Gt(CT)2.292015-11-0410.1016/j.str.2015.09.015
4X1H (No Gprot) ASensoryOpsinsRhodopsinBos taurusNonyl-β-D-Glucopyranoside-2.292015-11-0410.1016/j.str.2015.09.015
4ZWJASensoryOpsinsRhodopsinHomo sapiens--Arrestin13.32015-07-2910.1038/nature14656
4WW3ASensoryOpsinsRhodopsinTodarodes pacificusAll-trans-Retinal--2.82015-06-1710.1371/journal.pone.0126970
4PXFASensoryOpsinsRhodopsinBos taurusOctyl-β-D-Glucopyranoside-Arrestin1 Finger Loop2.752014-09-1710.1038/ncomms5801
4J4QASensoryOpsinsRhodopsinBos taurusOctyl β-D-Glucopyranoside-Gt(CT)2.652013-10-3010.1002/anie.201302374
4J4Q (No Gprot) ASensoryOpsinsRhodopsinBos taurusOctyl β-D-Glucopyranoside-2.652013-10-3010.1002/anie.201302374
4BEYASensoryOpsinsRhodopsinBos taurus--Gt(CT)2.92013-05-0810.1038/embor.2013.44
4BEY (No Gprot) ASensoryOpsinsRhodopsinBos taurus--2.92013-05-0810.1038/embor.2013.44
4BEZASensoryOpsinsRhodopsinBos taurus---3.32013-04-2410.1038/embor.2013.44
4A4MASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal-Gt(CT)3.32012-01-2510.1073/pnas.1114089108
4A4M (No Gprot) ASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal-3.32012-01-2510.1073/pnas.1114089108
3AYNASensoryOpsinsRhodopsinTodarodes pacificus9-cis-Retinal--2.72011-08-1710.1016/j.jmb.2011.08.044
3AYMASensoryOpsinsRhodopsinTodarodes pacificusAll-trans-Retinal--2.82011-08-1710.1016/j.jmb.2011.08.044
2X72ASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal-Gt(CT)32011-03-1610.1038/nature09795
2X72 (No Gprot) ASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal-32011-03-1610.1038/nature09795
3PXOASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal--32011-03-0910.1038/nature09789
3PQRASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal-Gt(CT)2.852011-03-0910.1038/nature09789
3PQR (No Gprot) ASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal-2.852011-03-0910.1038/nature09789
3OAXASensoryOpsinsRhodopsinBos taurus11-cis-Retinal--2.62011-01-1910.1016/j.bpj.2010.08.003
3DQBASensoryOpsinsRhodopsinBos taurus--Gt(CT)3.22008-09-2310.1038/nature07330
3DQB (No Gprot) ASensoryOpsinsRhodopsinBos taurus--3.22008-09-2310.1038/nature07330
3C9MASensoryOpsinsRhodopsinBos taurus11-cis-Retinal--3.42008-08-0510.1107/S0907444908017162
3C9LASensoryOpsinsRhodopsinBos taurus11-cis-Retinal--2.652008-08-0510.1107/S0907444908017162
3CAPASensoryOpsinsRhodopsinBos taurus---2.92008-06-2410.1038/nature07063
3CAP (Multimeric) ASensoryOpsinsRhodopsinBos taurus--2.92008-06-2410.1038/nature07063
2Z73ASensoryOpsinsRhodopsinTodarodes pacificus11-cis-Retinal--2.52008-05-1310.1038/nature06925
2ZIYASensoryOpsinsRhodopsinTodarodes pacificus11-cis-Retinal--3.72008-05-0610.1074/jbc.C800040200
2PEDASensoryOpsinsRhodopsinBos taurus9-cis-Retinal--2.952007-10-3010.1529/biophysj.107.108225
2J4YASensoryOpsinsRhodopsinBos taurus11-cis-Retinal--3.42007-09-2510.1016/j.jmb.2007.03.007
2I37ASensoryOpsinsRhodopsinBos taurus---4.152006-10-1710.1073/pnas.0608022103
2I36ASensoryOpsinsRhodopsinBos taurus---4.12006-10-1710.1073/pnas.0608022103
2I35ASensoryOpsinsRhodopsinBos taurus11-cis-Retinal--3.82006-10-1710.1073/pnas.0608022103
2G87ASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal--2.62006-09-0210.1002/anie.200600595
2HPYASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal--2.82006-08-2210.1073/pnas.0601765103
1U19ASensoryOpsinsRhodopsinBos taurus11-cis-Retinal--2.22004-10-1210.1016/j.jmb.2004.07.044
1GZMASensoryOpsinsRhodopsinBos taurus11-cis-Retinal--2.652003-11-2010.1016/j.jmb.2004.08.090
1L9HASensoryOpsinsRhodopsinBos taurus11-cis-Retinal--2.62002-05-1510.1073/pnas.082666399
1HZXASensoryOpsinsRhodopsinBos taurus11-cis-Retinal--2.82001-07-0410.1021/bi0155091
1F88ASensoryOpsinsRhodopsinBos taurus11-cis-Retinal--2.82000-08-0410.1126/science.289.5480.739




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