psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L30	R:R:W455	2.28	No	Yes	0	9	9
2	R:R:L34	R:R:V33	2.98	No	No	0	8	4
3	R:R:I37	R:R:V33	3.07	No	No	0	7	4
4	R:R:L34	R:R:M81	4.24	No	Yes	0	8	9
5	R:R:I85	R:R:L34	4.28	No	No	0	8	8
6	R:R:I37	R:R:I459	5.89	No	No	0	7	6
7	R:R:C38	R:R:M81	6.48	No	Yes	0	9	9
8	R:R:C38	R:R:P82	1.88	No	No	0	9	9
9	R:R:L39	R:R:V40	2.98	No	No	0	7	4
10	R:R:N45	R:R:T41	4.39	Yes	No	3	9	9
11	R:R:D73	R:R:T41	4.34	Yes	No	3	9	9
12	R:R:T41	R:R:T462	14.13	No	No	0	9	9
13	R:R:L44	R:R:N45	6.87	No	Yes	3	9	9
14	R:R:L44	R:R:P465	3.28	No	No	3	9	9
15	R:R:D73	R:R:N45	13.46	Yes	Yes	3	9	9
16	R:R:L74	R:R:N45	4.12	No	Yes	0	8	9
17	R:R:N45	R:R:P465	4.89	Yes	No	3	9	9
18	R:R:L46	R:R:Y50	5.86	No	No	0	8	5
19	R:R:F475	R:R:V48	2.62	Yes	No	0	9	9
20	R:R:L49	R:R:S70	6.01	No	No	0	8	9
21	R:R:L49	R:R:L74	4.15	No	No	0	8	8
22	R:R:R53	R:R:Y50	9.26	No	No	0	6	5
23	R:R:A51	R:R:F475	2.77	No	Yes	0	9	9
24	R:R:V52	R:R:V67	4.81	No	No	0	8	8
25	R:R:R53	R:R:S54	5.27	No	No	0	6	7
26	R:R:E55	R:R:L58	14.58	No	No	0	8	9
27	R:R:E55	R:R:H59	3.69	No	No	0	8	8
28	R:R:E55	R:R:T478	12.7	No	No	0	8	8
29	R:R:L58	R:R:N63	12.36	No	No	0	9	9
30	R:R:H59	R:R:T60	2.74	No	No	0	8	9
31	R:R:G62	R:R:T60	1.82	No	No	0	8	9
32	R:R:T140	R:R:V61	3.17	Yes	No	0	9	9
33	R:R:K141	R:R:V61	4.55	No	No	0	8	9
34	R:R:N63	R:R:Y468	8.14	No	Yes	0	9	9
35	R:R:L64	R:R:Y65	9.38	No	Yes	0	8	8
36	R:R:I120	R:R:Y65	7.25	Yes	Yes	6	8	8
37	R:R:L121	R:R:Y65	5.86	No	Yes	0	9	8
38	R:R:D124	R:R:Y65	10.34	No	Yes	6	9	8
39	R:R:A144	R:R:Y65	4	No	Yes	0	9	8
40	R:R:T147	R:R:Y65	7.49	No	Yes	6	8	8
41	R:R:I148	R:R:Y65	8.46	No	Yes	0	9	8
42	R:R:I66	R:R:L121	2.85	No	No	0	9	9
43	R:R:I66	R:R:Y468	21.76	No	Yes	0	9	9
44	R:R:S70	R:R:V67	3.23	No	No	0	9	8
45	R:R:S117	R:R:S68	6.52	No	No	0	8	9
46	R:R:L69	R:R:S117	4.5	No	No	0	9	8
47	R:R:L69	R:R:V118	4.47	No	No	0	9	9
48	R:R:A72	R:R:S114	3.42	No	No	0	9	9
49	R:R:D73	R:R:V76	2.92	Yes	Yes	3	9	9
50	R:R:D73	R:R:S461	2.94	Yes	No	3	9	9
51	R:R:D73	R:R:P465	4.83	Yes	No	3	9	9
52	R:R:I75	R:R:V79	3.07	No	No	0	8	6
53	R:R:A110	R:R:I75	3.25	No	No	0	8	8
54	R:R:G77	R:R:V76	3.68	No	Yes	0	9	9
55	R:R:S461	R:R:V76	3.23	No	Yes	3	9	9
56	R:R:G77	R:R:M81	1.75	No	Yes	0	9	9
57	R:R:M106	R:R:V79	7.61	No	No	0	8	6
58	R:R:V80	R:R:W103	9.81	No	No	0	9	9
59	R:R:D107	R:R:V80	7.3	No	No	1	9	9
60	R:R:V80	R:R:Y458	6.31	No	Yes	1	9	9
61	R:R:M81	R:R:N84	4.21	Yes	Yes	1	9	8
62	R:R:M81	R:R:Y458	5.99	Yes	Yes	1	9	9
63	R:R:L95	R:R:M83	2.83	No	No	0	9	8
64	R:R:M83	R:R:W103	10.47	No	No	0	8	9
65	R:R:M451	R:R:N84	8.41	Yes	Yes	1	6	8
66	R:R:I454	R:R:N84	4.25	Yes	Yes	1	8	8
67	R:R:N84	R:R:Y458	4.65	Yes	Yes	1	8	9
68	R:R:K92	R:R:Y87	4.78	Yes	No	0	2	7
69	R:R:C180	R:R:Y87	2.69	No	No	0	9	7
70	R:R:M451	R:R:Y87	2.39	Yes	No	0	6	7
71	R:R:L88	R:R:M451	9.9	No	Yes	1	8	6
72	R:R:L88	R:R:W455	2.28	No	Yes	1	8	9
73	R:R:L89	R:R:M90	2.83	No	No	8	6	5
74	R:R:L89	R:R:W93	13.67	No	No	8	6	9
75	R:R:M90	R:R:S91	3.07	No	No	0	5	3
76	R:R:M90	R:R:W93	17.45	No	No	8	5	9
77	R:R:K92	R:R:S91	3.06	Yes	No	0	2	3
78	R:R:D178	R:R:K92	2.77	No	Yes	0	3	2
79	R:R:K179	R:R:K92	7.18	No	Yes	0	4	2
80	R:R:G96	R:R:S94	1.86	No	No	0	8	5
81	R:R:L95	R:R:L99	9.69	No	No	0	9	7
82	R:R:P98	R:R:R97	2.88	No	No	0	5	5
83	R:R:L101	R:R:R97	4.86	No	No	9	8	5
84	R:R:R97	R:R:T182	9.06	No	No	9	5	9
85	R:R:C100	R:R:C180	7.28	No	No	0	9	9
86	R:R:L101	R:R:T182	7.37	No	No	9	8	9
87	R:R:F102	R:R:M106	3.73	No	No	0	8	8
88	R:R:C180	R:R:W103	2.61	No	No	0	9	9
89	R:R:L104	R:R:Y108	4.69	No	Yes	2	9	9
90	R:R:I162	R:R:L104	5.71	Yes	No	0	9	9
91	R:R:D183	R:R:L104	6.79	Yes	No	2	7	9
92	R:R:S105	R:R:V159	4.85	No	No	0	9	5
93	R:R:I162	R:R:S105	4.64	Yes	No	0	9	9
94	R:R:D107	R:R:Y458	3.45	No	Yes	1	9	9
95	R:R:W158	R:R:Y108	10.61	Yes	Yes	0	8	9
96	R:R:D183	R:R:Y108	3.45	Yes	Yes	2	7	9
97	R:R:K191	R:R:Y108	3.58	No	Yes	0	9	9
98	R:R:F156	R:R:V109	7.87	No	No	0	5	9
99	R:R:V109	R:R:W158	2.45	No	Yes	0	9	8
100	R:R:S111	R:R:T112	3.2	No	No	0	9	9
101	R:R:N198	R:R:T112	13.16	No	No	0	9	9
102	R:R:A113	R:R:S155	3.42	No	No	0	9	9
103	R:R:F116	R:R:I115	3.77	No	Yes	4	8	9
104	R:R:I115	R:R:N198	4.25	Yes	No	0	9	9
105	R:R:I115	R:R:P202	3.39	Yes	No	4	9	9
106	R:R:F424	R:R:I115	3.77	Yes	Yes	4	9	9
107	R:R:F116	R:R:L154	4.87	No	No	0	8	7
108	R:R:F116	R:R:P202	5.78	No	No	4	8	9
109	R:R:M206	R:R:V118	4.56	No	No	0	9	9
110	R:R:F119	R:R:I120	5.02	No	Yes	0	8	8
111	R:R:F119	R:R:L205	8.53	No	No	0	8	6
112	R:R:F119	R:R:F209	3.22	No	No	0	8	7
113	R:R:I120	R:R:I123	4.42	Yes	No	6	8	6
114	R:R:D124	R:R:I120	4.2	No	Yes	6	9	8
115	R:R:I120	R:R:T147	3.04	Yes	No	6	8	8
116	R:R:C122	R:R:F209	5.59	No	No	0	8	7
117	R:R:D124	R:R:I123	2.8	No	No	6	9	6
118	R:R:F209	R:R:I123	8.79	No	No	0	7	6
119	R:R:I213	R:R:R125	5.01	Yes	No	0	9	9
120	R:R:A413	R:R:R125	4.15	No	No	0	9	9
121	R:R:A414	R:R:R125	4.15	No	No	0	9	9
122	R:R:Q130	R:R:Y126	11.27	No	No	0	8	9
123	R:R:K212	R:R:Y126	3.58	No	No	0	5	9
124	R:R:I213	R:R:Y126	4.84	Yes	No	0	9	9
125	R:R:Q131	R:R:R127	5.84	Yes	No	10	7	8
126	R:R:R127	R:R:R139	7.46	No	No	10	8	9
127	R:R:R127	R:R:T140	6.47	No	Yes	0	8	9
128	R:R:S128	R:R:T140	3.2	No	Yes	0	9	9
129	R:R:Q130	R:R:R134	5.84	No	No	0	8	5
130	R:R:P132	R:R:Q131	3.16	No	Yes	0	9	7
131	R:R:Q131	R:R:R134	5.84	Yes	No	0	7	5
132	R:R:Q131	R:R:R139	4.67	Yes	No	10	7	9
133	R:R:I148	R:R:L149	2.85	No	No	0	9	7
134	R:R:L149	R:R:W152	2.28	No	No	0	7	9
135	R:R:F153	R:R:L149	2.44	No	No	0	5	7
136	R:R:I162	R:R:W158	3.52	Yes	Yes	0	9	8
137	R:R:T194	R:R:W158	7.28	No	Yes	0	8	8
138	R:R:L163	R:R:V159	4.47	No	No	0	7	5
139	R:R:I160	R:R:P161	3.39	No	No	0	8	9
140	R:R:F168	R:R:G164	3.01	No	No	0	6	7
141	R:R:F184	R:R:W165	21.05	Yes	No	2	9	9
142	R:R:V187	R:R:W165	2.45	Yes	No	2	8	9
143	R:R:N166	R:R:Q170	17.17	No	No	0	6	5
144	R:R:F168	R:R:M169	8.71	No	No	0	6	5
145	R:R:K179	R:R:R176	6.19	No	No	0	4	1
146	R:R:D183	R:R:E181	3.9	Yes	No	0	7	7
147	R:R:E181	R:R:Y185	32.55	No	No	0	7	7
148	R:R:D183	R:R:F184	10.75	Yes	Yes	2	7	9
149	R:R:F184	R:R:V187	5.24	Yes	Yes	2	9	8
150	R:R:F184	R:R:K191	4.96	Yes	No	0	9	9
151	R:R:V187	R:R:W189	4.9	Yes	No	2	8	5
152	R:R:F190	R:R:V187	6.55	No	Yes	2	9	8
153	R:R:F440	R:R:T188	6.49	No	No	0	7	8
154	R:R:F190	R:R:W189	15.03	No	No	2	9	5
155	R:R:K191	R:R:T194	3	No	No	0	9	8
156	R:R:M436	R:R:V192	6.09	No	No	0	7	8
157	R:R:A195	R:R:F435	2.77	No	No	0	9	8
158	R:R:I196	R:R:Y200	6.04	No	No	0	7	8
159	R:R:F199	R:R:Y200	9.28	Yes	No	0	9	8
160	R:R:F199	R:R:T203	7.78	Yes	No	4	9	9
161	R:R:F199	R:R:F424	3.22	Yes	Yes	4	9	9
162	R:R:F199	R:R:I425	2.51	Yes	No	4	9	8
163	R:R:F199	R:R:I429	2.51	Yes	No	0	9	8
164	R:R:F199	R:R:F432	18.22	Yes	No	0	9	9
165	R:R:M436	R:R:Y200	2.39	No	No	0	7	8
166	R:R:L201	R:R:L204	6.92	No	No	0	7	5
167	R:R:I425	R:R:T203	4.56	No	No	4	8	9
168	R:R:L204	R:R:L205	2.77	No	No	0	5	6
169	R:R:M206	R:R:M421	5.78	No	No	0	9	9
170	R:R:K212	R:R:W208	3.48	No	No	0	5	4
171	R:R:K218	R:R:Y214	14.33	No	No	0	7	8
172	R:R:K218	R:R:V217	3.04	No	Yes	0	7	9
173	R:R:E410	R:R:V217	8.56	No	Yes	0	8	9
174	R:R:N408	R:R:R411	2.41	No	No	0	7	7
175	R:R:K415	R:R:R411	6.19	No	No	0	7	7
176	R:R:F419	R:R:K415	8.69	No	No	0	7	7
177	R:R:L417	R:R:Q416	2.66	No	Yes	0	9	9
178	R:R:I420	R:R:Q416	4.12	No	Yes	0	9	9
179	R:R:Q416	R:R:Y468	2.25	Yes	Yes	0	9	9
180	R:R:C471	R:R:Q416	3.05	No	Yes	0	9	9
181	R:R:G418	R:R:M421	1.75	No	No	0	8	9
182	R:R:I420	R:R:N464	2.83	No	No	0	9	9
183	R:R:F424	R:R:I425	5.02	Yes	No	4	9	8
184	R:R:F424	R:R:W428	9.02	Yes	Yes	0	9	9
185	R:R:C427	R:R:L456	6.35	No	No	0	9	9
186	R:R:C427	R:R:N460	11.02	No	Yes	0	9	9
187	R:R:F432	R:R:W428	4.01	No	Yes	0	9	9
188	R:R:G457	R:R:W428	8.44	No	Yes	0	9	9
189	R:R:W428	R:R:Y458	1.93	Yes	Yes	0	9	9
190	R:R:N460	R:R:W428	12.43	Yes	Yes	0	9	9
191	R:R:I429	R:R:P430	5.08	No	No	0	8	9
192	R:R:P430	R:R:T453	1.75	No	No	0	9	9
193	R:R:F435	R:R:Y431	14.44	No	No	0	8	9
194	R:R:T453	R:R:Y431	9.99	No	No	0	9	9
195	R:R:I454	R:R:Y431	10.88	Yes	No	0	8	9
196	R:R:F432	R:R:F435	6.43	No	No	0	9	8
197	R:R:F434	R:R:I438	10.05	Yes	Yes	5	7	6
198	R:R:F434	R:R:N446	2.42	Yes	No	5	7	6
199	R:R:F434	R:R:L449	12.18	Yes	No	0	7	4
200	R:R:F434	R:R:H450	18.1	Yes	Yes	5	7	7
201	R:R:F434	R:R:T453	3.89	Yes	No	0	7	9
202	R:R:C441	R:R:I438	4.91	No	Yes	5	7	6
203	R:R:C444	R:R:I438	6.55	No	Yes	5	5	6
204	R:R:H450	R:R:I438	9.28	Yes	Yes	5	7	6
205	R:R:C441	R:R:N443	4.72	No	No	0	7	4
206	R:R:C441	R:R:C444	5.46	No	No	5	7	5
207	R:R:H450	R:R:N446	2.55	Yes	No	5	7	6
208	R:R:E447	R:R:H448	14.77	No	No	0	4	2
209	R:R:F452	R:R:L449	2.44	No	No	0	5	4
210	R:R:I454	R:R:M451	4.37	Yes	Yes	1	8	6
211	R:R:M451	R:R:W455	4.65	Yes	Yes	1	6	9
212	R:R:F452	R:R:W455	14.03	No	Yes	0	5	9
213	R:R:F452	R:R:L456	4.87	No	No	0	5	9
214	R:R:I454	R:R:Y458	6.04	Yes	Yes	1	8	9
215	R:R:N460	R:R:N464	5.45	Yes	No	11	9	9
216	R:R:L463	R:R:T462	2.95	No	No	0	8	9
217	R:R:L463	R:R:L466	9.69	No	No	0	8	7
218	R:R:P469	R:R:Y468	5.56	No	Yes	7	9	9
219	R:R:F475	R:R:Y468	4.13	Yes	Yes	7	9	9
220	R:R:F475	R:R:P469	7.22	Yes	No	7	9	9
221	R:R:F479	R:R:P469	5.78	No	No	7	9	9
222	R:R:C471	R:R:L470	3.17	No	No	0	9	8
223	R:R:E473	R:R:N472	2.63	No	No	0	5	9
224	R:R:N472	R:R:N474	4.09	No	No	0	9	9
225	R:R:F475	R:R:N472	3.62	Yes	No	0	9	9
226	R:R:F475	R:R:T478	2.59	Yes	No	0	9	8
227	R:R:F475	R:R:F479	11.79	Yes	No	7	9	9
228	R:R:F479	R:R:K476	3.72	No	No	0	9	8
229	R:R:K476	R:R:K480	7.18	No	No	0	8	8
230	R:R:K477	R:R:R481	3.71	No	No	0	7	6
231	R:R:C38	R:R:V42	1.71	No	No	0	9	6
232	R:R:G43	R:R:L46	1.71	No	No	0	6	8
233	R:R:G96	R:R:L99	1.71	No	No	0	8	7
234	R:R:G164	R:R:L163	1.71	No	No	0	7	7
235	R:R:A110	R:R:V76	1.7	No	Yes	0	8	9
236	R:R:A78	R:R:V79	1.7	No	No	0	7	6
237	R:R:A439	R:R:V192	1.7	No	No	0	8	8
238	R:R:C100	R:R:T182	1.69	No	No	0	9	9
239	R:R:A439	R:R:T188	1.68	No	No	0	8	8
240	R:R:L30	R:R:P29	1.64	No	No	0	9	3
241	R:R:S70	R:R:V71	1.62	No	No	0	9	6
242	R:R:V31	R:R:V32	1.6	No	No	0	7	4
243	R:R:V32	R:R:V33	1.6	No	No	0	4	4
244	R:R:S35	R:R:T36	1.6	No	No	0	7	5
245	R:R:S155	R:R:T112	1.6	No	No	0	9	9
246	R:R:T36	R:R:V40	1.59	No	No	0	5	4
247	R:R:G164	R:R:H167	1.59	No	No	0	7	4
248	R:R:A423	R:R:N460	1.56	No	Yes	11	8	9
249	R:R:A423	R:R:N464	1.56	No	No	11	8	9
250	R:R:I213	R:R:V129	1.54	Yes	No	0	9	9
251	R:R:I213	R:R:V217	1.54	Yes	Yes	0	9	9
252	R:R:I433	R:R:V437	1.54	No	No	0	7	8
253	R:R:F153	R:R:G150	1.51	No	No	0	5	5
254	R:R:L69	R:R:S114	1.5	No	No	0	9	9
255	R:R:L44	R:R:V40	1.49	No	No	0	9	4
256	R:R:L221	R:R:V217	1.49	No	Yes	0	5	9
257	R:R:L64	R:R:T140	1.47	No	Yes	0	8	9
258	R:R:I196	R:R:I197	1.47	No	No	0	7	5
259	R:R:I429	R:R:I433	1.47	No	No	0	8	7
260	R:R:K412	R:R:K415	1.44	No	No	0	9	7
261	R:R:I85	R:R:L86	1.43	No	No	0	8	6
262	R:R:I162	R:R:L101	1.43	Yes	No	0	9	8
263	R:R:Q220	R:R:V129	1.43	No	No	0	8	9
264	R:R:I160	R:R:L163	1.43	No	No	0	8	7
265	R:R:I467	R:R:L470	1.43	No	No	0	9	8
266	R:R:L417	R:R:M421	1.41	No	No	0	9	9
267	R:R:C471	R:R:F419	1.4	No	No	0	9	7
268	R:R:L154	R:R:L157	1.38	No	No	0	7	5
269	R:R:R143	R:R:T142	1.29	No	No	0	9	6
270	R:R:E447	R:R:H450	1.23	No	Yes	0	4	7
271	R:R:N408	R:R:R409	1.21	No	No	0	7	8
272	R:R:K215	R:R:Y214	1.19	No	No	0	6	8
273	R:R:Q220	R:R:R219	1.17	No	No	0	8	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:N45	6.746	5	3	9
2	R:R:Y65	7.54	7	6	8
3	R:R:D73	5.698	5	3	9
4	R:R:V76	2.8825	4	3	9
5	R:R:M81	4.534	5	1	9
6	R:R:N84	5.38	4	1	8
7	R:R:K92	4.4475	4	0	2
8	R:R:Y108	5.5825	4	2	9
9	R:R:I115	3.795	4	4	9
10	R:R:I120	4.786	5	6	8
11	R:R:Q131	4.8775	4	10	7
12	R:R:T140	3.5775	4	0	9
13	R:R:W158	5.965	4	0	8
14	R:R:I162	3.825	4	0	9
15	R:R:D183	6.2225	4	2	7
16	R:R:F184	10.5	4	2	9
17	R:R:V187	4.785	4	2	8
18	R:R:F199	7.25333	6	4	9
19	R:R:I213	3.2325	4	0	9
20	R:R:V217	3.6575	4	0	9
21	R:R:Q416	3.02	4	0	9
22	R:R:F424	5.2575	4	4	9
23	R:R:W428	7.166	5	0	9
24	R:R:F434	9.328	5	5	7
25	R:R:I438	7.6975	4	5	6
26	R:R:H450	7.79	4	5	7
27	R:R:M451	5.944	5	1	6
28	R:R:I454	6.385	4	1	8
29	R:R:W455	5.81	4	1	9
30	R:R:Y458	4.72833	6	1	9
31	R:R:N460	7.615	4	11	9
32	R:R:Y468	8.368	5	7	9
33	R:R:F475	4.96286	7	7	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:M451	R:R:N84	22.666	8.41	Yes	Yes	1	6	8
2	R:R:M81	R:R:N84	17.062	4.21	Yes	Yes	1	9	8
3	R:R:L34	R:R:M81	14.196	4.24	No	Yes	0	8	9
4	R:R:G77	R:R:M81	52.6392	1.75	No	Yes	0	9	9
5	R:R:G77	R:R:V76	51.1743	3.68	No	Yes	0	9	9
6	R:R:D73	R:R:V76	38.9025	2.92	Yes	Yes	3	9	9
7	R:R:D73	R:R:N45	20.4337	13.46	Yes	Yes	3	9	9
8	R:R:L44	R:R:V40	13.9228	1.49	No	No	0	9	4
9	R:R:D73	R:R:P465	10.2372	4.83	Yes	No	3	9	9
10	R:R:L74	R:R:N45	10.5976	4.12	No	Yes	0	8	9
11	R:R:F475	R:R:Y468	20.3465	4.13	Yes	Yes	7	9	9
12	R:R:Q416	R:R:Y468	87.2457	2.25	Yes	Yes	0	9	9
13	R:R:I420	R:R:Q416	99.4187	4.12	No	Yes	0	9	9
14	R:R:I420	R:R:N464	100	2.83	No	No	0	9	9
15	R:R:N460	R:R:N464	99.9128	5.45	Yes	No	11	9	9
16	R:R:C427	R:R:N460	11.2254	11.02	No	Yes	0	9	9
17	R:R:C427	R:R:L456	10.2081	6.35	No	No	0	9	9
18	R:R:I66	R:R:Y468	65.5796	21.76	No	Yes	0	9	9
19	R:R:I66	R:R:L121	64.6902	2.85	No	No	0	9	9
20	R:R:L121	R:R:Y65	63.7368	5.86	No	Yes	0	9	8
21	R:R:L64	R:R:Y65	38.2921	9.38	No	Yes	0	8	8
22	R:R:L64	R:R:T140	36.9376	1.47	No	Yes	0	8	9
23	R:R:I120	R:R:Y65	15.0331	7.25	Yes	Yes	6	8	8
24	R:R:L417	R:R:Q416	15.5738	2.66	No	Yes	0	9	9
25	R:R:L417	R:R:M421	14.0681	1.41	No	No	0	9	9
26	R:R:M206	R:R:M421	11.022	5.78	No	No	0	9	9
27	R:R:A110	R:R:V76	10.772	1.7	No	Yes	0	8	9
28	R:R:N84	R:R:Y458	10.1674	4.65	Yes	Yes	1	8	9
29	R:R:V80	R:R:Y458	44.4599	6.31	No	Yes	1	9	9
30	R:R:I454	R:R:M451	14.9401	4.37	Yes	Yes	1	8	6
31	R:R:I454	R:R:Y458	16.033	6.04	Yes	Yes	1	8	9
32	R:R:M451	R:R:Y87	35.0831	2.39	Yes	No	0	6	7
33	R:R:C180	R:R:Y87	18.1084	2.69	No	No	0	9	7
34	R:R:C180	R:R:W103	38.3676	2.61	No	No	0	9	9
35	R:R:K92	R:R:Y87	19.1082	4.78	Yes	No	0	2	7
36	R:R:C100	R:R:C180	53.831	7.28	No	No	0	9	9
37	R:R:C100	R:R:T182	52.3486	1.69	No	No	0	9	9
38	R:R:L101	R:R:T182	47.4945	7.37	No	No	9	8	9
39	R:R:I162	R:R:L104	18.8815	5.71	Yes	No	0	9	9
40	R:R:I162	R:R:L101	46.2679	1.43	Yes	No	0	9	8
41	R:R:I162	R:R:W158	11.7661	3.52	Yes	Yes	0	9	8
42	R:R:D183	R:R:L104	13.8821	6.79	Yes	No	2	7	9
43	R:R:I162	R:R:S105	16.0098	4.64	Yes	No	0	9	9
44	R:R:S105	R:R:V159	14.3007	4.85	No	No	0	9	5
45	R:R:W428	R:R:Y458	93.1055	1.93	Yes	Yes	0	9	9
46	R:R:F424	R:R:W428	33.624	9.02	Yes	Yes	0	9	9
47	R:R:F424	R:R:I115	14.9227	3.77	Yes	Yes	4	9	9
48	R:R:R127	R:R:T140	31.88	6.47	No	Yes	0	8	9
49	R:R:Q131	R:R:R127	29.2175	5.84	Yes	No	10	7	8
50	R:R:Q131	R:R:R134	26.5144	5.84	Yes	No	0	7	5
51	R:R:Q130	R:R:R134	25.1017	5.84	No	No	0	8	5
52	R:R:Q130	R:R:Y126	23.6775	11.27	No	No	0	8	9
53	R:R:I213	R:R:Y126	19.5035	4.84	Yes	No	0	9	9
54	R:R:L163	R:R:V159	12.5218	4.47	No	No	0	7	5
55	R:R:M436	R:R:V192	11.551	6.09	No	No	0	7	8
56	R:R:M436	R:R:Y200	14.2077	2.39	No	No	0	7	8
57	R:R:F199	R:R:Y200	22.7183	9.28	Yes	No	0	9	8
58	R:R:F199	R:R:F424	18.5037	3.22	Yes	Yes	4	9	9
59	R:R:F199	R:R:F432	18.2653	18.22	Yes	No	0	9	9
60	R:R:F432	R:R:W428	21.5149	4.01	No	Yes	0	9	9
61	R:R:I454	R:R:Y431	14.8355	10.88	Yes	No	0	8	9
62	R:R:T453	R:R:Y431	11.7544	9.99	No	No	0	9	9
63	R:R:C471	R:R:Q416	13.9286	3.05	No	Yes	0	9	9
64	R:R:N460	R:R:W428	93.4717	12.43	Yes	Yes	0	9	9
65	R:R:M81	R:R:Y458	52.0405	5.99	Yes	Yes	1	9	9
66	R:R:V80	R:R:W103	43.8205	9.81	No	No	0	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 8X5X

PDB Summary
PDB	8X5X
Class	A
SubFamily	Amine
Type	Histamine
SubType	H1
Species	Homo sapiens
Ligand	-
Other Ligand(s)	-
Protein Partners	-
PDB Resolution	3.5
Date	2024-01-17
D.O.I.	10.1038/s41467-023-44477-4

Net Summary
I_min	1.75
Number of Linked Nodes	240
Number of Links	273
Number of Hubs	33
Number of Links mediated by Hubs	123
Number of Communities	11
Number of Nodes involved in Communities	58
Number of Links involved in Communities	74

Path Summary
Number Of Nodes in MetaPath	67
Number Of Links MetaPath	66
Number of Shortest Paths	37704
Length Of Smallest Path	3
Average Path Length	14.0752
Length of Longest Path	35
Minimum Path Strength	1.3
Average Path Strength	5.60397
Maximum Path Strength	18.225
Minimum Path Correlation	0.7
Average Path Correlation	0.919257
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.22581
Average % Of Corr. Nodes	40.8847
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	41.1954
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P35367
Sequence	>8X5X_Chain_R P L V V V L S T I C L V T V G L N L L V L Y A V R S E L H T V G N L Y I V S L S V A D L I V G A V V M P M N I L Y L L M S K W S L G R P L C L F W L S M D Y V A S T A S I F S V F I L C I D R Y R S V Q Q P L R R T K T R A S A T I L G A W F L S F L W V I P I L G W N H F M Q R E D K C E T D F Y D V T W F K V M T A I I N F Y L P T L L M L W F Y A K I Y K A V K R Q L N R E R K A A K Q L G F I M A A F I L C W I P Y F I F F M V I A F C K N C C N E H L H M F T I W L G Y I N S T L N P L I Y P L C N E N F K K T F K R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	2RH1	A	Amine	Adrenergic	β₂	Homo sapiens	(S)-Carazolol	-	-	2.4	2007-10-30	10.1126/science.1150577
	8GH1	A	Amine	Adrenergic	β₂	Homo sapiens	Epinephrine	-	-	4.1	2024-03-06	10.1038/s41586-024-07153-1
	3RZE	A	Amine	Histamine	H₁	Homo sapiens	Cidoxepin	-	-	3.1	2011-06-15	10.1038/nature10236
	7DFL	A	Amine	Histamine	H₁	Homo sapiens	Histamine	-	chim(NtGi1L-Gq)/&β;1/&γ;2	3.3	2021-03-31	10.1038/s41467-021-22427-2
	8X5Y	A	Amine	Histamine	H₁	Homo sapiens	Astemizole	-	-	3	2024-01-17	10.1038/s41467-023-44477-4
	8X63	A	Amine	Histamine	H₁	Homo sapiens	Mepyramine	-	-	3.2	2024-01-17	10.1038/s41467-023-44477-4
	8X64	A	Amine	Histamine	H₁	Homo sapiens	Desloratadine	-	-	3.4	2024-01-17	10.1038/s41467-023-44477-4
	6FJ3	B1	Peptide	Parathyroid hormone	PTH1	Homo sapiens	PTH	-	-	2.5	2018-11-21	10.1038/s41594-018-0151-4
	6NBF	B1	Peptide	Parathyroid hormone	PTH1	Homo sapiens	Long-acting PTH analog	-	Gs/&β;1/&γ;2	3	2019-04-17	10.1126/science.aav7942
	6NBH	B1	Peptide	Parathyroid hormone	PTH1	Homo sapiens	Long-acting PTH analog	-	Gs/&β;1/&γ;2	3.5	2019-04-17	10.1126/science.aav7942
	6NBI	B1	Peptide	Parathyroid hormone	PTH1	Homo sapiens	Long-acting PTH analog	-	Gs/&β;1/&γ;2	4	2019-04-17	10.1126/science.aav7942
	7VVJ	B1	Peptide	Parathyroid hormone	PTH1	Homo sapiens	PTHrP(1-36)	-	Gs/&β;1/&γ;2	3.2	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVK	B1	Peptide	Parathyroid hormone	PTH1	Homo sapiens	PTH	-	Gs/&β;1/&γ;2	3.3	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVL	B1	Peptide	Parathyroid hormone	PTH1	Homo sapiens	PTH	-	Gs/&β;1/&γ;2	2.8	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVM	B1	Peptide	Parathyroid hormone	PTH1	Homo sapiens	PTH	-	Gs/&β;1/&γ;2	3.2	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVN	B1	Peptide	Parathyroid hormone	PTH1	Homo sapiens	PTH	-	Gs/&β;1/&γ;2	3.8	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVO	B1	Peptide	Parathyroid hormone	PTH1	Homo sapiens	PTH	-	Gs/&β;1/&γ;2	4.1	2022-08-03	10.1016/j.molcel.2022.07.003
	7Y35	B1	Peptide	Parathyroid hormone	PTH1	Homo sapiens	Abaloparatide	-	Gs/&β;1/&γ;2	2.9	2023-07-05	To be published
	7Y36	B1	Peptide	Parathyroid hormone	PTH1	Homo sapiens	Teriparatide	-	Gs/&β;1/&γ;2	2.8	2023-07-05	To be published
	8FLQ	B1	Peptide	Parathyroid hormone	PTH1	Homo sapiens	PTH	-	Gs/&β;1/&γ;2	2.55	2023-04-26	10.1016/j.str.2023.04.002
	8FLR	B1	Peptide	Parathyroid hormone	PTH1	Homo sapiens	PTHrP(1-36)	-	Gs/&β;1/&γ;2	2.94	2023-04-26	10.1016/j.str.2023.04.002
	8FLS	B1	Peptide	Parathyroid hormone	PTH1	Homo sapiens	Abaloparatide	-	Gs/&β;1/&γ;2	3.09	2023-04-26	10.1016/j.str.2023.04.002
	8FLT	B1	Peptide	Parathyroid hormone	PTH1	Homo sapiens	M-PTH(1-14)	-	Gs/&β;1/&γ;2	3.03	2023-04-26	10.1016/j.str.2023.04.002
	8FLU	B1	Peptide	Parathyroid hormone	PTH1	Homo sapiens	Long-acting PTH	-	Gs/&β;1/&γ;2	2.76	2023-04-26	10.1016/j.str.2023.04.002
	8GW8	B1	Peptide	Parathyroid hormone	PTH1	Homo sapiens	-	KHF	Gs/&β;1/&γ;2	2.9	2023-06-14	10.1038/s41586-023-06169-3
	8HA0	B1	Peptide	Parathyroid hormone	PTH1	Homo sapiens	PTH	-	chim(NtGi1-Gs)/&β;1/&γ;2	2.62	2022-12-21	10.1038/s41401-022-01032-z
	8HAF	B1	Peptide	Parathyroid hormone	PTH1	Homo sapiens	PTHrP(1-36)	-	chim(NtGi1-Gs)/&β;1/&γ;2	3.25	2022-12-21	10.1038/s41401-022-01032-z
	8HAO	B1	Peptide	Parathyroid hormone	PTH1	Homo sapiens	PTH	-	chim(NtGi1-Gs)/&β;1/&γ;2	3.76	2022-12-21	10.1038/s41401-022-01032-z
	8JR9	B1	Peptide	Parathyroid hormone	PTH1	Homo sapiens	-	PCO371	chim(NtGi1-Gs)/&β;1/&γ;2	2.57	2023-08-02	10.1038/s41586-023-06467-w

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8X5X.zip

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