psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D107	7.66	Yes	No	1	0	9
2	L:L:?1	R:R:Y108	27.58	Yes	Yes	1	0	9
3	L:L:?1	R:R:S111	9.89	Yes	No	1	0	9
4	L:L:?1	R:R:W158	8.58	Yes	Yes	1	0	8
5	L:L:?1	R:R:N198	5.17	Yes	No	0	0	9
6	L:L:?1	R:R:W428	4.29	Yes	Yes	1	0	9
7	L:L:?1	R:R:Y431	19.86	Yes	Yes	1	0	9
8	L:L:?1	R:R:F435	4.59	Yes	Yes	1	0	8
9	R:R:I85	R:R:V31	4.61	Yes	No	0	8	7
10	R:R:L89	R:R:V31	4.47	No	No	0	6	7
11	R:R:I85	R:R:L34	5.71	Yes	No	1	8	8
12	R:R:L34	R:R:W455	20.5	No	Yes	1	8	9
13	R:R:I37	R:R:T462	4.56	No	No	0	7	9
14	R:R:C38	R:R:M81	4.86	No	Yes	0	9	9
15	R:R:C38	R:R:P82	3.77	No	No	0	9	9
16	R:R:T41	R:R:T462	10.99	No	No	0	9	9
17	R:R:L44	R:R:P465	4.93	No	No	0	9	9
18	R:R:L44	R:R:L466	4.15	No	No	0	9	7
19	R:R:D73	R:R:N45	6.73	Yes	Yes	0	9	9
20	R:R:L74	R:R:N45	6.87	No	Yes	0	8	9
21	R:R:N45	R:R:P465	4.89	Yes	No	0	9	9
22	R:R:L46	R:R:L74	5.54	No	No	4	8	8
23	R:R:F479	R:R:L47	3.65	No	No	0	9	9
24	R:R:S70	R:R:V48	6.46	No	No	0	9	9
25	R:R:F479	R:R:V48	5.24	No	No	0	9	9
26	R:R:R53	R:R:Y50	8.23	No	No	5	6	5
27	R:R:S54	R:R:Y50	8.9	No	No	5	7	5
28	R:R:A51	R:R:F479	4.16	No	No	0	9	9
29	R:R:V52	R:R:V67	4.81	No	No	0	8	8
30	R:R:R53	R:R:S54	5.27	No	No	5	6	7
31	R:R:E55	R:R:L58	5.3	No	Yes	2	8	9
32	R:R:E55	R:R:T478	18.34	No	Yes	2	8	8
33	R:R:E55	R:R:R481	10.47	No	No	2	8	6
34	R:R:H59	R:R:R56	4.51	No	No	0	8	8
35	R:R:K57	R:R:N474	8.39	No	Yes	0	7	9
36	R:R:L58	R:R:N63	4.12	Yes	No	2	9	9
37	R:R:L58	R:R:N474	4.12	Yes	Yes	0	9	9
38	R:R:F475	R:R:L58	7.31	Yes	Yes	2	9	9
39	R:R:L58	R:R:T478	4.42	Yes	Yes	2	9	8
40	R:R:N63	R:R:T60	5.85	No	No	0	9	9
41	R:R:F475	R:R:N63	12.08	Yes	No	2	9	9
42	R:R:K141	R:R:L64	4.23	No	No	0	8	8
43	R:R:I120	R:R:Y65	7.25	No	Yes	0	8	8
44	R:R:L121	R:R:Y65	7.03	No	Yes	0	9	8
45	R:R:D124	R:R:Y65	17.24	No	Yes	0	9	8
46	R:R:A144	R:R:Y65	4	No	Yes	0	9	8
47	R:R:I148	R:R:Y65	3.63	No	Yes	0	9	8
48	R:R:I66	R:R:P469	6.77	No	No	0	9	9
49	R:R:S117	R:R:S68	4.89	No	No	0	8	9
50	R:R:I148	R:R:S68	6.19	No	No	0	9	9
51	R:R:S68	R:R:W152	6.18	No	No	0	9	9
52	R:R:D73	R:R:L69	5.43	Yes	No	3	9	9
53	R:R:L69	R:R:N464	12.36	No	No	3	9	9
54	R:R:V71	R:R:W152	3.68	No	No	0	6	9
55	R:R:D73	R:R:S114	4.42	Yes	No	0	9	9
56	R:R:D73	R:R:S461	7.36	Yes	No	0	9	9
57	R:R:D73	R:R:N464	8.08	Yes	No	3	9	9
58	R:R:G77	R:R:V76	3.68	No	No	0	9	9
59	R:R:S461	R:R:V76	8.08	No	No	0	9	9
60	R:R:V80	R:R:W103	6.13	No	Yes	1	9	9
61	R:R:D107	R:R:V80	7.3	No	No	1	9	9
62	R:R:V80	R:R:Y458	6.31	No	Yes	1	9	9
63	R:R:M81	R:R:W455	8.14	Yes	Yes	1	9	9
64	R:R:M81	R:R:Y458	7.18	Yes	Yes	1	9	9
65	R:R:F102	R:R:M83	3.73	No	No	0	8	8
66	R:R:M83	R:R:W103	10.47	No	Yes	0	8	9
67	R:R:L88	R:R:N84	4.12	No	Yes	1	8	8
68	R:R:N84	R:R:W103	5.65	Yes	Yes	1	8	9
69	R:R:M451	R:R:N84	7.01	No	Yes	1	6	8
70	R:R:N84	R:R:W455	11.3	Yes	Yes	1	8	9
71	R:R:N84	R:R:Y458	6.98	Yes	Yes	1	8	9
72	R:R:I85	R:R:W455	4.7	Yes	Yes	1	8	9
73	R:R:L86	R:R:L95	4.15	No	No	0	6	9
74	R:R:W93	R:R:Y87	6.75	Yes	No	0	9	7
75	R:R:K179	R:R:Y87	8.36	No	No	0	4	7
76	R:R:L88	R:R:M451	5.65	No	No	1	8	6
77	R:R:M90	R:R:S94	4.6	No	No	0	5	5
78	R:R:K92	R:R:S94	4.59	No	No	0	2	5
79	R:R:D178	R:R:K92	9.68	No	No	0	3	2
80	R:R:L95	R:R:W93	11.39	No	Yes	0	9	9
81	R:R:C100	R:R:W93	10.45	No	Yes	1	9	9
82	R:R:W103	R:R:W93	9.37	Yes	Yes	1	9	9
83	R:R:C180	R:R:W93	10.45	No	Yes	1	9	9
84	R:R:L95	R:R:L99	9.69	No	No	0	9	7
85	R:R:L101	R:R:R97	14.58	No	Yes	0	8	5
86	R:R:R175	R:R:R97	14.93	No	Yes	1	4	5
87	R:R:D183	R:R:R97	4.76	Yes	Yes	1	7	5
88	R:R:C100	R:R:C180	7.28	No	No	1	9	9
89	R:R:L101	R:R:L163	5.54	No	No	0	8	7
90	R:R:F102	R:R:M106	7.46	No	No	0	8	8
91	R:R:L104	R:R:W103	4.56	No	Yes	0	9	9
92	R:R:C180	R:R:W103	5.22	No	Yes	1	9	9
93	R:R:L104	R:R:T182	4.42	No	Yes	0	9	9
94	R:R:S105	R:R:V159	4.85	No	No	0	9	5
95	R:R:D107	R:R:Y458	12.64	No	Yes	1	9	9
96	R:R:W158	R:R:Y108	21.22	Yes	Yes	1	8	9
97	R:R:I162	R:R:Y108	4.84	No	Yes	0	9	9
98	R:R:T182	R:R:Y108	4.99	Yes	Yes	0	9	9
99	R:R:F156	R:R:V109	7.87	No	No	0	5	9
100	R:R:S111	R:R:W428	4.94	No	Yes	1	9	9
101	R:R:F116	R:R:T112	7.78	No	Yes	0	8	9
102	R:R:S155	R:R:T112	7.99	No	Yes	0	9	9
103	R:R:T112	R:R:W158	8.49	Yes	Yes	0	9	8
104	R:R:N198	R:R:T112	11.7	No	Yes	0	9	9
105	R:R:A113	R:R:W152	7.78	No	No	0	9	9
106	R:R:F116	R:R:I115	3.77	No	No	0	8	9
107	R:R:F424	R:R:I115	7.54	Yes	No	1	9	9
108	R:R:I115	R:R:W428	15.27	No	Yes	1	9	9
109	R:R:F116	R:R:L154	3.65	No	No	0	8	7
110	R:R:F424	R:R:V118	3.93	Yes	No	0	9	9
111	R:R:V118	R:R:Y468	7.57	No	No	0	9	9
112	R:R:F119	R:R:I123	8.79	Yes	No	0	8	6
113	R:R:F119	R:R:P202	4.33	Yes	No	0	8	9
114	R:R:F119	R:R:L205	8.53	Yes	No	0	8	6
115	R:R:F119	R:R:M206	4.98	Yes	No	0	8	9
116	R:R:I120	R:R:T147	6.08	No	No	0	8	8
117	R:R:L121	R:R:Y468	8.21	No	No	0	9	9
118	R:R:C122	R:R:M206	6.48	No	No	0	8	9
119	R:R:C122	R:R:F209	4.19	No	No	0	8	7
120	R:R:C122	R:R:Y210	9.41	No	No	0	8	9
121	R:R:F209	R:R:I123	3.77	No	No	0	7	6
122	R:R:D124	R:R:Y135	9.2	No	No	6	9	9
123	R:R:D124	R:R:R139	10.72	No	Yes	6	9	9
124	R:R:Q130	R:R:Y126	9.02	No	Yes	0	8	9
125	R:R:F209	R:R:Y126	16.5	No	Yes	0	7	9
126	R:R:I213	R:R:Y126	3.63	No	Yes	0	9	9
127	R:R:Q131	R:R:R127	7.01	No	No	0	7	8
128	R:R:R127	R:R:Y135	15.43	No	No	0	8	9
129	R:R:R139	R:R:S128	3.95	Yes	No	0	9	9
130	R:R:I213	R:R:V129	7.68	No	No	0	9	9
131	R:R:L133	R:R:R134	4.86	No	No	0	8	5
132	R:R:R139	R:R:Y135	14.4	Yes	No	6	9	9
133	R:R:K137	R:R:Y138	4.78	No	No	0	5	8
134	R:R:R143	R:R:Y138	10.29	No	No	0	9	8
135	R:R:R143	R:R:T140	9.06	No	No	0	9	9
136	R:R:F153	R:R:L157	9.74	No	No	0	5	5
137	R:R:P161	R:R:W158	5.4	No	Yes	0	9	8
138	R:R:F184	R:R:W158	6.01	Yes	Yes	1	9	8
139	R:R:F190	R:R:W158	4.01	Yes	Yes	1	9	8
140	R:R:T194	R:R:W158	4.85	No	Yes	1	8	8
141	R:R:I160	R:R:P161	5.08	No	No	0	8	9
142	R:R:F184	R:R:W165	11.02	Yes	Yes	1	9	9
143	R:R:V187	R:R:W165	4.9	No	Yes	0	8	9
144	R:R:F190	R:R:W165	6.01	Yes	Yes	1	9	9
145	R:R:D183	R:R:N166	6.73	Yes	No	0	7	6
146	R:R:D183	R:R:R175	7.15	Yes	No	1	7	4
147	R:R:K179	R:R:R176	11.14	No	No	0	4	1
148	R:R:E447	R:R:K179	6.75	No	No	0	4	4
149	R:R:E181	R:R:T182	7.06	No	Yes	0	7	9
150	R:R:E181	R:R:Y185	8.98	No	No	0	7	7
151	R:R:E181	R:R:H450	3.69	No	No	0	7	7
152	R:R:F184	R:R:T182	18.16	Yes	Yes	0	9	9
153	R:R:F184	R:R:F190	10.72	Yes	Yes	1	9	9
154	R:R:D186	R:R:Y185	5.75	No	No	7	3	7
155	R:R:N443	R:R:Y185	13.96	No	No	7	4	7
156	R:R:D186	R:R:N443	6.73	No	No	7	3	4
157	R:R:V187	R:R:W189	7.36	No	No	0	8	5
158	R:R:F440	R:R:T188	3.89	No	No	0	7	8
159	R:R:F190	R:R:W189	9.02	Yes	No	0	9	5
160	R:R:F190	R:R:T194	7.78	Yes	No	1	9	8
161	R:R:F435	R:R:K191	22.33	Yes	No	0	8	9
162	R:R:I438	R:R:K191	5.82	No	No	0	6	9
163	R:R:A439	R:R:K191	6.42	No	No	0	8	9
164	R:R:F435	R:R:T194	5.19	Yes	No	1	8	8
165	R:R:F432	R:R:N198	7.25	Yes	No	0	9	9
166	R:R:F199	R:R:Y200	8.25	Yes	No	0	9	8
167	R:R:F199	R:R:T203	9.08	Yes	No	0	9	9
168	R:R:F199	R:R:F424	4.29	Yes	Yes	1	9	9
169	R:R:F199	R:R:W428	5.01	Yes	Yes	1	9	9
170	R:R:F199	R:R:I429	5.02	Yes	Yes	0	9	8
171	R:R:F199	R:R:F432	17.15	Yes	Yes	1	9	9
172	R:R:M436	R:R:Y200	4.79	No	No	0	7	8
173	R:R:F424	R:R:M206	6.22	Yes	No	0	9	9
174	R:R:L207	R:R:M421	5.65	No	No	0	7	9
175	R:R:K212	R:R:W208	6.96	No	No	0	5	4
176	R:R:L417	R:R:Y210	8.21	No	No	0	9	9
177	R:R:E410	R:R:Y214	8.98	No	No	0	8	8
178	R:R:A414	R:R:Y214	5.34	No	No	0	9	8
179	R:R:K215	R:R:R218	3.71	No	No	0	6	7
180	R:R:A413	R:R:V217	5.09	No	No	0	9	9
181	R:R:E410	R:R:R218	8.14	No	No	0	8	7
182	R:R:H220	R:R:Q219	6.18	No	No	0	8	5
183	R:R:C221	R:R:E410	4.56	No	No	0	5	8
184	R:R:I420	R:R:Q416	4.12	No	No	0	9	9
185	R:R:C471	R:R:Q416	6.1	No	No	0	9	9
186	R:R:F419	R:R:I467	8.79	No	No	0	7	9
187	R:R:I420	R:R:Y468	6.04	No	No	0	9	9
188	R:R:F424	R:R:W428	6.01	Yes	Yes	1	9	9
189	R:R:I425	R:R:I429	4.42	No	Yes	0	8	8
190	R:R:C427	R:R:N460	7.87	No	No	0	9	9
191	R:R:W428	R:R:Y431	3.86	Yes	Yes	1	9	9
192	R:R:F432	R:R:W428	7.02	Yes	Yes	1	9	9
193	R:R:G457	R:R:W428	7.04	No	Yes	0	9	9
194	R:R:N460	R:R:W428	13.56	No	Yes	0	9	9
195	R:R:I429	R:R:P430	5.08	Yes	No	0	8	9
196	R:R:I429	R:R:I433	4.42	Yes	No	0	8	7
197	R:R:F432	R:R:Y431	8.25	Yes	Yes	1	9	9
198	R:R:F435	R:R:Y431	7.22	Yes	Yes	1	8	9
199	R:R:T453	R:R:Y431	4.99	No	Yes	0	9	9
200	R:R:F434	R:R:I438	12.56	Yes	No	0	7	6
201	R:R:C445	R:R:F434	4.19	No	Yes	0	5	7
202	R:R:F434	R:R:L449	7.31	Yes	No	0	7	4
203	R:R:F434	R:R:H450	15.84	Yes	No	0	7	7
204	R:R:F434	R:R:T453	3.89	Yes	No	0	7	9
205	R:R:C441	R:R:C444	7.28	No	No	0	7	5
206	R:R:H448	R:R:N446	7.65	No	No	0	2	6
207	R:R:H450	R:R:I454	9.28	No	No	0	7	8
208	R:R:F452	R:R:L456	7.31	No	No	0	5	9
209	R:R:I454	R:R:Y458	7.25	No	Yes	0	8	9
210	R:R:W455	R:R:Y458	10.61	Yes	Yes	1	9	9
211	R:R:N460	R:R:N464	5.45	No	No	0	9	9
212	R:R:F475	R:R:P469	10.11	Yes	No	0	9	9
213	R:R:N472	R:R:N474	5.45	No	Yes	0	9	9
214	R:R:F475	R:R:N472	8.46	Yes	No	0	9	9
215	R:R:K476	R:R:K480	4.31	No	No	0	8	8
216	R:R:K477	R:R:R481	6.19	No	No	0	7	6
217	R:R:R481	R:R:T478	3.88	No	Yes	2	6	8
218	R:R:M421	R:R:Y210	3.59	No	No	0	9	9
219	R:R:K212	R:R:Y126	3.58	No	Yes	0	5	9
220	R:R:Q416	R:R:R125	3.5	No	No	0	9	9
221	R:R:Q131	R:R:R134	3.5	No	No	0	7	5
222	R:R:A72	R:R:S114	3.42	No	No	0	9	9
223	R:R:A110	R:R:V76	3.39	No	No	0	8	9
224	R:R:A51	R:R:T478	3.36	No	Yes	0	9	8
225	R:R:D183	R:R:W165	3.35	Yes	Yes	1	7	9
226	R:R:L201	R:R:P202	3.28	No	No	0	7	9
227	R:R:L456	R:R:P430	3.28	No	No	0	9	9
228	R:R:A110	R:R:I75	3.25	No	No	0	8	8
229	R:R:A151	R:R:I120	3.25	No	No	0	7	8
230	R:R:S155	R:R:V109	3.23	No	No	0	9	9
231	R:R:A195	R:R:M436	3.22	No	No	0	9	7
232	R:R:P29	R:R:Q26	3.16	No	No	0	3	5
233	R:R:I85	R:R:S35	3.1	Yes	No	0	8	7
234	R:R:I37	R:R:V33	3.07	No	No	0	7	4
235	R:R:K141	R:R:V61	3.04	No	No	0	8	9
236	R:R:M106	R:R:V79	3.04	No	No	0	8	6
237	R:R:M436	R:R:V192	3.04	No	No	0	7	8
238	R:R:M81	R:R:T41	3.01	Yes	No	0	9	9
239	R:R:L49	R:R:S70	3	No	No	0	8	9
240	R:R:L44	R:R:V40	2.98	No	No	0	9	4
241	R:R:L46	R:R:V42	2.98	No	Yes	4	8	6
242	R:R:L74	R:R:V42	2.98	No	Yes	4	8	6
243	R:R:N45	R:R:S70	2.98	Yes	No	0	9	9
244	R:R:L163	R:R:V159	2.98	No	No	0	7	5
245	R:R:I197	R:R:M193	2.92	No	No	0	5	7
246	R:R:G62	R:R:Y65	2.9	No	Yes	0	8	8
247	R:R:P98	R:R:R97	2.88	No	Yes	0	5	5
248	R:R:I482	R:R:L47	2.85	No	No	0	8	9
249	R:R:I459	R:R:L463	2.85	No	No	0	6	8
250	R:R:L86	R:R:M90	2.83	No	No	0	6	5
251	R:R:G96	R:R:W93	2.81	No	Yes	0	8	9
252	R:R:C221	R:R:R409	2.79	No	No	0	5	8
253	R:R:L466	R:R:L470	2.77	No	No	0	7	8
254	R:R:F475	R:R:V52	2.62	Yes	No	0	9	8
255	R:R:R139	R:R:V61	2.62	Yes	No	0	9	9
256	R:R:F440	R:R:V192	2.62	No	No	0	7	8
257	R:R:I482	R:R:Y50	2.42	No	No	0	8	5
258	R:R:G43	R:R:V42	1.84	No	Yes	0	6	6
259	R:R:G150	R:R:L149	1.71	No	No	0	5	7
260	R:R:C221	R:R:V217	1.71	No	No	0	5	9
261	R:R:G418	R:R:L417	1.71	No	No	0	8	9
262	R:R:C445	R:R:V437	1.71	No	No	0	5	8
263	R:R:A78	R:R:V42	1.7	No	Yes	0	7	6
264	R:R:A216	R:R:V129	1.7	No	No	0	6	9
265	R:R:M28	R:R:P29	1.68	No	No	0	5	3
266	R:R:A423	R:R:I467	1.62	No	No	0	8	9
267	R:R:T36	R:R:V32	1.59	No	No	0	5	4
268	R:R:T36	R:R:V40	1.59	No	No	0	5	4
269	R:R:G164	R:R:H167	1.59	No	No	0	7	4
270	R:R:P132	R:R:Q131	1.58	No	No	0	9	7
271	R:R:A422	R:R:L426	1.58	No	No	0	8	5
272	R:R:T140	R:R:T142	1.57	No	No	0	9	6
273	R:R:I196	R:R:V192	1.54	No	No	0	7	8
274	R:R:I213	R:R:V217	1.54	No	No	0	9	9
275	R:R:M28	R:R:V32	1.52	No	No	0	5	4
276	R:R:F153	R:R:G150	1.51	No	No	0	5	5
277	R:R:L64	R:R:S145	1.5	No	No	0	8	6
278	R:R:K442	R:R:T188	1.5	No	No	0	3	8
279	R:R:I420	R:R:I467	1.47	No	No	0	9	9
280	R:R:I459	R:R:L456	1.43	No	No	0	6	9
281	R:R:L154	R:R:L157	1.38	No	No	0	7	5
282	R:R:L204	R:R:L207	1.38	No	No	0	5	7
283	R:R:E447	R:R:N446	1.31	No	No	0	4	6
284	R:R:E473	R:R:N474	1.31	No	Yes	0	5	9
285	R:R:D178	R:R:E177	1.3	No	No	0	3	3
286	R:R:A211	R:R:W208	1.3	No	No	0	4	4
287	R:R:H167	R:R:N166	1.28	No	No	0	4	6
288	R:R:N408	R:R:R411	1.21	No	No	0	7	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	10.9525	8	1	0
2	R:R:V42	2.375	4	4	6
3	R:R:N45	5.3675	4	0	9
4	R:R:L58	5.054	5	2	9
5	R:R:Y65	7.00833	6	0	8
6	R:R:D73	6.404	5	3	9
7	R:R:M81	5.7975	4	1	9
8	R:R:N84	7.012	5	1	8
9	R:R:I85	4.53	4	1	8
10	R:R:W93	8.53667	6	1	9
11	R:R:R97	9.2875	4	1	5
12	R:R:W103	6.9	6	1	9
13	R:R:Y108	14.6575	4	1	9
14	R:R:T112	8.99	4	0	9
15	R:R:F119	6.6575	4	0	8
16	R:R:Y126	8.1825	4	0	9
17	R:R:R139	7.9225	4	6	9
18	R:R:W158	8.36572	7	1	8
19	R:R:W165	6.32	4	1	9
20	R:R:T182	8.6575	4	0	9
21	R:R:D183	5.4975	4	1	7
22	R:R:F184	11.4775	4	1	9
23	R:R:F190	7.508	5	1	9
24	R:R:F199	8.13333	6	1	9
25	R:R:F424	5.598	5	1	9
26	R:R:W428	7.44444	9	1	9
27	R:R:I429	4.735	4	0	8
28	R:R:Y431	8.836	5	1	9
29	R:R:F432	9.9175	4	1	9
30	R:R:F434	8.758	5	0	7
31	R:R:F435	9.8325	4	1	8
32	R:R:W455	11.05	5	1	9
33	R:R:Y458	8.495	6	1	9
34	R:R:N474	4.8175	4	0	9
35	R:R:F475	8.116	5	2	9
36	R:R:T478	7.5	4	2	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D107	61.7696	7.66	Yes	No	1	0	9
2	R:R:D107	R:R:Y458	26.976	12.64	No	Yes	1	9	9
3	R:R:M81	R:R:Y458	14.5688	7.18	Yes	Yes	1	9	9
4	L:L:?1	R:R:W428	100	4.29	Yes	Yes	1	0	9
5	R:R:N460	R:R:W428	86.548	13.56	No	Yes	0	9	9
6	R:R:N460	R:R:N464	84.1559	5.45	No	No	0	9	9
7	R:R:D73	R:R:N464	81.3387	8.08	Yes	No	3	9	9
8	R:R:D73	R:R:N45	71.3308	6.73	Yes	Yes	0	9	9
9	R:R:N45	R:R:P465	19.0143	4.89	Yes	No	0	9	9
10	R:R:L44	R:R:P465	17.177	4.93	No	No	0	9	9
11	R:R:N45	R:R:S70	47.8132	2.98	Yes	No	0	9	9
12	R:R:S70	R:R:V48	44.5853	6.46	No	No	0	9	9
13	R:R:F479	R:R:V48	42.9642	5.24	No	No	0	9	9
14	R:R:A51	R:R:F479	33.1796	4.16	No	No	0	9	9
15	R:R:A51	R:R:T478	31.4576	3.36	No	Yes	0	9	8
16	R:R:L58	R:R:T478	24.3317	4.42	Yes	Yes	2	9	8
17	R:R:F475	R:R:L58	11.4994	7.31	Yes	Yes	2	9	9
18	R:R:F424	R:R:W428	78.5791	6.01	Yes	Yes	1	9	9
19	R:R:F424	R:R:V118	56.762	3.93	Yes	No	0	9	9
20	R:R:V118	R:R:Y468	55.3426	7.57	No	No	0	9	9
21	R:R:L121	R:R:Y468	44.1026	8.21	No	No	0	9	9
22	R:R:L121	R:R:Y65	42.5967	7.03	No	Yes	0	9	8
23	R:R:D124	R:R:Y65	23.0348	17.24	No	Yes	0	9	8
24	R:R:D124	R:R:R139	10.6348	10.72	No	Yes	6	9	9
25	R:R:I148	R:R:Y65	11.1463	3.63	No	Yes	0	9	8
26	R:R:D107	R:R:V80	33.5327	7.3	No	No	1	9	9
27	R:R:V80	R:R:W103	34.9089	6.13	No	Yes	1	9	9
28	R:R:W103	R:R:W93	35.9752	9.37	Yes	Yes	1	9	9
29	R:R:L95	R:R:W93	17.7462	11.39	No	Yes	0	9	9
30	R:R:L86	R:R:L95	13.3943	4.15	No	No	0	6	9
31	R:R:W93	R:R:Y87	13.1422	6.75	Yes	No	0	9	7
32	R:R:K179	R:R:Y87	10.9446	8.36	No	No	0	4	7
33	R:R:L86	R:R:M90	11.1968	2.83	No	No	0	6	5
34	L:L:?1	R:R:W158	46.2137	8.58	Yes	Yes	1	0	8
35	R:R:F184	R:R:W158	21.356	6.01	Yes	Yes	1	9	8
36	R:R:F184	R:R:W165	21.4497	11.02	Yes	Yes	1	9	9
37	R:R:D183	R:R:W165	33.6768	3.35	Yes	Yes	1	7	9
38	R:R:D183	R:R:R97	18.4379	4.76	Yes	Yes	1	7	5
39	R:R:L101	R:R:R97	12.5009	14.58	No	Yes	0	8	5
40	R:R:F190	R:R:W158	20.9669	4.01	Yes	Yes	1	9	8
41	R:R:F190	R:R:W165	17.8759	6.01	Yes	Yes	1	9	9
42	R:R:T182	R:R:Y108	10.2169	4.99	Yes	Yes	0	9	9
43	R:R:L104	R:R:T182	12.4721	4.42	No	Yes	0	9	9
44	R:R:T112	R:R:W158	13.4448	8.49	Yes	Yes	0	9	8
45	R:R:S155	R:R:T112	11.73	7.99	No	Yes	0	9	9
46	R:R:F116	R:R:T112	12.7531	7.78	No	Yes	0	8	9
47	R:R:F116	R:R:I115	13.5312	3.77	No	No	0	8	9
48	R:R:F116	R:R:L154	15.5198	3.65	No	No	0	8	7
49	R:R:F424	R:R:M206	51.2069	6.22	Yes	No	0	9	9
50	R:R:C122	R:R:M206	41.6961	6.48	No	No	0	8	9
51	R:R:C122	R:R:F209	30.629	4.19	No	No	0	8	7
52	R:R:C122	R:R:Y210	11.1247	9.41	No	No	0	8	9
53	R:R:D124	R:R:Y135	10.6564	9.2	No	No	6	9	9
54	R:R:F209	R:R:Y126	29.5771	16.5	No	Yes	0	7	9
55	R:R:I213	R:R:Y126	21.075	3.63	No	Yes	0	9	9
56	R:R:L154	R:R:L157	12.4433	1.38	No	No	0	7	5
57	R:R:T453	R:R:Y431	10.3177	4.99	No	Yes	0	9	9
58	R:R:F199	R:R:W428	21.9108	5.01	Yes	Yes	1	9	9
59	R:R:F199	R:R:Y200	15.5343	8.25	Yes	No	0	9	8
60	R:R:M436	R:R:Y200	13.6177	4.79	No	No	0	7	8
61	R:R:F199	R:R:I429	15.7288	5.02	Yes	Yes	0	9	8
62	R:R:I213	R:R:V217	15.8153	1.54	No	No	0	9	9
63	R:R:C221	R:R:V217	12.4649	1.71	No	No	0	5	9
64	R:R:I420	R:R:Y468	12.4865	6.04	No	No	0	9	9
65	R:R:L44	R:R:V40	11.5786	2.98	No	No	0	9	4
66	R:R:L104	R:R:W103	11.5354	4.56	No	Yes	0	9	9
67	R:R:W428	R:R:Y431	13.8843	3.86	Yes	Yes	1	9	9
68	R:R:F199	R:R:F424	10.4907	4.29	Yes	Yes	1	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:D107	7.66	1	Yes	No	0	9	0	1
L:L:?1	R:R:Y108	27.58	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:S111	9.89	1	Yes	No	0	9	0	1
L:L:?1	R:R:W158	8.58	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:N198	5.17	1	Yes	No	0	9	0	1
L:L:?1	R:R:W428	4.29	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:Y431	19.86	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:F435	4.59	1	Yes	Yes	0	8	0	1
R:R:D107	R:R:V80	7.3	1	No	No	9	9	1	2
R:R:V80	R:R:Y458	6.31	1	No	Yes	9	9	2	2
R:R:D107	R:R:Y458	12.64	1	No	Yes	9	9	1	2
R:R:W158	R:R:Y108	21.22	1	Yes	Yes	8	9	1	1
R:R:I162	R:R:Y108	4.84	0	No	Yes	9	9	2	1
R:R:T182	R:R:Y108	4.99	0	Yes	Yes	9	9	2	1
R:R:S111	R:R:W428	4.94	1	No	Yes	9	9	1	1
R:R:T112	R:R:W158	8.49	0	Yes	Yes	9	8	2	1
R:R:N198	R:R:T112	11.7	0	No	Yes	9	9	1	2
R:R:F424	R:R:I115	7.54	1	Yes	No	9	9	2	2
R:R:I115	R:R:W428	15.27	1	No	Yes	9	9	2	1
R:R:P161	R:R:W158	5.4	0	No	Yes	9	8	2	1
R:R:F184	R:R:W158	6.01	1	Yes	Yes	9	8	2	1
R:R:F190	R:R:W158	4.01	1	Yes	Yes	9	8	2	1
R:R:T194	R:R:W158	4.85	1	No	Yes	8	8	2	1
R:R:F184	R:R:T182	18.16	1	Yes	Yes	9	9	2	2
R:R:F184	R:R:F190	10.72	1	Yes	Yes	9	9	2	2
R:R:F190	R:R:T194	7.78	1	Yes	No	9	8	2	2
R:R:F435	R:R:K191	22.33	1	Yes	No	8	9	1	2
R:R:F435	R:R:T194	5.19	1	Yes	No	8	8	1	2
R:R:F432	R:R:N198	7.25	1	Yes	No	9	9	2	1
R:R:F199	R:R:F424	4.29	1	Yes	Yes	9	9	2	2
R:R:F199	R:R:W428	5.01	1	Yes	Yes	9	9	2	1
R:R:F199	R:R:F432	17.15	1	Yes	Yes	9	9	2	2
R:R:F424	R:R:W428	6.01	1	Yes	Yes	9	9	2	1
R:R:W428	R:R:Y431	3.86	1	Yes	Yes	9	9	1	1
R:R:F432	R:R:W428	7.02	1	Yes	Yes	9	9	2	1
R:R:G457	R:R:W428	7.04	0	No	Yes	9	9	2	1
R:R:N460	R:R:W428	13.56	0	No	Yes	9	9	2	1
R:R:F432	R:R:Y431	8.25	1	Yes	Yes	9	9	2	1
R:R:F435	R:R:Y431	7.22	1	Yes	Yes	8	9	1	1
R:R:T453	R:R:Y431	4.99	0	No	Yes	9	9	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9LRB_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.63
Number of Linked Nodes	257
Number of Links	288
Number of Hubs	36
Number of Links mediated by Hubs	138
Number of Communities	7
Number of Nodes involved in Communities	53
Number of Links involved in Communities	75

Path Summary
Number Of Nodes in MetaPath	69
Number Of Links MetaPath	68
Number of Shortest Paths	35782
Length Of Smallest Path	3
Average Path Length	11.6962
Length of Longest Path	26
Minimum Path Strength	1.435
Average Path Strength	6.74488
Maximum Path Strength	23.72
Minimum Path Correlation	0.7
Average Path Correlation	0.915535
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.7619
Average % Of Corr. Nodes	51.2584
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	42.751
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • biological regulation • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • regulation of biological process • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • regulation of localization • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • localization • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • intracellular protein localization • regulation of peptide hormone secretion • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • export from cell • cell-cell signaling • regulation of protein transport • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • cellular localization • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • cytoskeletal protein binding • spectrin binding • protein-containing complex binding • protein binding • binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • hydrolase activity • catalytic activity • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity, acting on acid anhydrides • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • response to decreased oxygen levels • cellular response to stimulus • response to stimulus • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to chemical stimulus • cellular response to stress • response to hypoxia • response to stress • response to chemical • response to oxygen levels • response to abiotic stimulus • cellular process • cell population proliferation • regulation of biological process • regulation of cellular process • signaling • phospholipase C-activating G protein-coupled receptor signaling pathway • cell communication • G protein-coupled receptor signaling pathway • signal transduction • muscle cell apoptotic process • striated muscle cell apoptotic process • apoptotic process • cell death • programmed cell death • cardiac muscle cell apoptotic process • photoreceptor inner segment • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor outer segment • photoreceptor cell cilium • ciliary membrane • photoreceptor outer segment membrane • bounding membrane of organelle • plasma membrane region • cell projection membrane • synapse • cell junction • cell body • G-protein beta-subunit binding • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • G protein-coupled amine receptor activity • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • histamine receptor activity • regulation of tube diameter • regulation of tube size • regulation of system process • positive regulation of biological process • positive regulation of vasoconstriction • circulatory system process • regulation of blood circulation • vascular process in circulatory system • regulation of vasoconstriction • positive regulation of multicellular organismal process • regulation of multicellular organismal process • blood vessel diameter maintenance • vasoconstriction • blood circulation • regulation of anatomical structure size • trans-synaptic signaling • synaptic signaling • anterograde trans-synaptic signaling • cell-cell signaling • chemical synaptic transmission • regulation of synaptic plasticity • regulation of signaling • modulation of chemical synaptic transmission • regulation of trans-synaptic signaling • regulation of cell communication • response to histamine • cellular response to histamine • defense response • inflammatory response • regulation of vascular permeability • behavior • learning or memory • cognition • memory • response to light stimulus • learning • visual learning • visual behavior • associative learning • response to radiation • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	HSM
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	HSM
Name	Histamine
Synonyms	1H-Imidazole-4-ethanamine
Identifier
Formula	C5 H9 N3
Molecular Weight	111.145
SMILES
PubChem	774
Formal Charge	0
Total Atoms	17
Total Chiral Atoms	0
Total Bonds	17
Total Aromatic Bonds	5


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P35367
Sequence	>9LRB_nogp_Chain_R Q L M P L V V V L S T I C L V T V G L N L L V L Y A V R S E R K L H T V G N L Y I V S L S V A D L I V G A V V M P M N I L Y L L M S K W S L G R P L C L F W L S M D Y V A S T A S I F S V F I L C I D R Y R S V Q Q P L R Y L K Y R T K T R A S A T I L G A W F L S F L W V I P I L G W N H F R R E D K C E T D F Y D V T W F K V M T A I I N F Y L P T L L M L W F Y A K I Y K A V R Q H C Q H N R E R K A A K Q L G F I M A A F I L C W I P Y F I F F M V I A F C K N C C N E H L H M F T I W L G Y I N S T L N P L I Y P L C N E N F K K T F K R I Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8GH1	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	4.1	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	2RH1	A	Amine	Adrenergic	β₂	Homo sapiens	S-Carazolol	-	-	2.4	2007-10-30	doi.org/10.1126/science.1150577
	3RZE	A	Amine	Histamine	H₁	Homo sapiens	Cidoxepin	-	-	3.1	2011-06-15	doi.org/10.1038/nature10236
	7DFL	A	Amine	Histamine	H₁	Homo sapiens	Histamine	-	chim(NtGi1L-Gq)/β1/γ2	3.3	2021-03-31	doi.org/10.1038/s41467-021-22427-2
	7DFL (No Gprot)	A	Amine	Histamine	H₁	Homo sapiens	Histamine	-		3.3	2021-03-31	doi.org/10.1038/s41467-021-22427-2
	8X5X	A	Amine	Histamine	H₁	Homo sapiens	-	-	-	3.5	2024-01-17	doi.org/10.1038/s41467-023-44477-4
	8X5Y	A	Amine	Histamine	H₁	Homo sapiens	Astemizole	-	-	3	2024-01-17	doi.org/10.1038/s41467-023-44477-4
	8X63	A	Amine	Histamine	H₁	Homo sapiens	Mepyramine	-	-	3.2	2024-01-17	doi.org/10.1038/s41467-023-44477-4
	8X64	A	Amine	Histamine	H₁	Homo sapiens	Desloratadine	-	-	3.4	2024-01-17	doi.org/10.1038/s41467-023-44477-4
	8YN2	A	Amine	Histamine	H₁	Homo sapiens	Histamine	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.66	2024-10-09	doi.org/10.1038/s41467-024-52585-y
	8YN2 (No Gprot)	A	Amine	Histamine	H₁	Homo sapiens	Histamine	-		2.66	2024-10-09	doi.org/10.1038/s41467-024-52585-y
	9LRD	A	Amine	Histamine	H₁	Homo sapiens	Histamine	-	Gi1/β1/γ2	3.23	2025-06-11	To be published
	9LRD (No Gprot)	A	Amine	Histamine	H₁	Homo sapiens	Histamine	-		3.23	2025-06-11	To be published
	9LRB	A	Amine	Histamine	H₁	Homo sapiens	Histamine	-	Gs/β1/γ2	2.77	2025-06-11	To be published
	9LRB (No Gprot)	A	Amine	Histamine	H₁	Homo sapiens	Histamine	-		2.77	2025-06-11	To be published
	8WSS	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	Pro-MCH	-	Gi1/β1/γ1	3.01	2024-06-19	doi.org/10.1038/s41421-024-00679-8
	8WSS (No Gprot)	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	Pro-MCH	-		3.01	2024-06-19	doi.org/10.1038/s41421-024-00679-8
	8YNS	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	SNAP-94847	-	-	3.33	2024-12-18	doi.org/10.1038/s41421-024-00754-0
	8YNT	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	SNAP-94847	-	-	3.43	2024-12-18	doi.org/10.1038/s41421-024-00754-0
	8WWK	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	MCH	-	Gi1/β1/γ2	2.61	2024-11-13	doi.org/10.1038/s41421-024-00754-0
	8WWK (No Gprot)	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	MCH	-		2.61	2024-11-13	doi.org/10.1038/s41421-024-00754-0
	8WWL	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	MCH	-	Gi1/β1/γ2	2.78	2024-11-13	doi.org/10.1038/s41421-024-00754-0
	8WWL (No Gprot)	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	MCH	-		2.78	2024-11-13	doi.org/10.1038/s41421-024-00754-0
	8WWM	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	MCH	-	Gi1/β1/γ2	2.81	2024-11-13	doi.org/10.1038/s41421-024-00754-0
	8WWM (No Gprot)	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	MCH	-		2.81	2024-11-13	doi.org/10.1038/s41421-024-00754-0
	8WWN	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	MCH	-	Gi1/β1/γ2	2.65	2024-11-13	doi.org/10.1038/s41421-024-00754-0
	8WWN (No Gprot)	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	MCH	-		2.65	2024-11-13	doi.org/10.1038/s41421-024-00754-0
	8WWH	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	-	-	Gi1/β1/γ2	2.84	2024-11-13	To be published
	8WWH (No Gprot)	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	-	-		2.84	2024-11-13	To be published
	8WWI	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	-	-	Gi1/β1/γ2	3.43	2024-11-13	To be published
	8WWI (No Gprot)	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	-	-		3.43	2024-11-13	To be published
	8WWJ	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	-	-	Gi1/β1/γ2	3.03	2024-11-13	To be published
	8WWJ (No Gprot)	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	-	-		3.03	2024-11-13	To be published
	8GW8	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	-	PCO371	Gs/β1/γ2	2.9	2023-06-14	doi.org/10.1038/s41586-023-06169-3
	8GW8 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	-	PCO371		2.9	2023-06-14	doi.org/10.1038/s41586-023-06169-3
	8JR9	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	-	PCO371	chim(NtGi1-Gs)/β1/γ2	2.57	2023-08-02	doi.org/10.1038/s41586-023-06467-w
	8JR9 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	-	PCO371		2.57	2023-08-02	doi.org/10.1038/s41586-023-06467-w
	7VVJ	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-	Gs/β1/γ2	3.2	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVJ (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-		3.2	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVK	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	3.3	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVK (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		3.3	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVL	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	2.8	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVL (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.8	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVM	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	3.2	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVM (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		3.2	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVN	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	3.8	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVN (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		3.8	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVO	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	4.1	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVO (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		4.1	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	8FLQ	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	2.55	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLQ (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.55	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLR	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-	Gs/β1/γ2	2.94	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLR (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-		2.94	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLS	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Abaloparatide	-	Gs/β1/γ2	3.09	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLS (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Abaloparatide	-		3.09	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLT	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	M-PTH(1-14)	-	Gs/β1/γ2	3.03	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLT (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	M-PTH(1-14)	-		3.03	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLU	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH	-	Gs/β1/γ2	2.76	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLU (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH	-		2.76	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8HA0	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	chim(NtGi1-Gs)/β1/γ2	2.62	2022-12-21	doi.org/10.1038/s41401-022-01032-z
	8HA0 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.62	2022-12-21	doi.org/10.1038/s41401-022-01032-z
	8HAF	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-	chim(NtGi1-Gs)/β1/γ2	3.25	2022-12-21	doi.org/10.1038/s41401-022-01032-z
	8HAF (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-		3.25	2022-12-21	doi.org/10.1038/s41401-022-01032-z
	8HAO	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	chim(NtGi1-Gs)/β1/γ2	3.76	2022-12-21	doi.org/10.1038/s41401-022-01032-z
	8HAO (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		3.76	2022-12-21	doi.org/10.1038/s41401-022-01032-z
	6FJ3	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	-	2.5	2018-11-21	doi.org/10.1038/s41594-018-0151-4
	6NBF	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-	Gs/β1/γ2	3	2019-04-17	doi.org/10.1126/science.aav7942
	6NBF (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-		3	2019-04-17	doi.org/10.1126/science.aav7942
	6NBH	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-	Gs/β1/γ2	3.5	2019-04-17	doi.org/10.1126/science.aav7942
	6NBH (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-		3.5	2019-04-17	doi.org/10.1126/science.aav7942
	6NBI	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-	Gs/β1/γ2	4	2019-04-17	doi.org/10.1126/science.aav7942
	6NBI (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-		4	2019-04-17	doi.org/10.1126/science.aav7942
	9B5Y	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH	-	chim(NtGi1-Gq)/β1/γ2	3.49	2025-03-19	doi.org/10.1073/pnas.2426178122
	9B5Y (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH	-		3.49	2025-03-19	doi.org/10.1073/pnas.2426178122
	7Y35	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Abaloparatide	-	Gs/β1/γ2	2.9	2023-07-05	To be published
	7Y35 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Abaloparatide	-		2.9	2023-07-05	To be published
	7Y36	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Teriparatide	-	Gs/β1/γ2	2.8	2023-07-05	To be published
	7Y36 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Teriparatide	-		2.8	2023-07-05	To be published
	9JR2	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.8	2024-10-16	To be published
	9JR2 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.8	2024-10-16	To be published
	9JR3	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.8	2024-10-16	To be published
	9JR3 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.8	2024-10-16	To be published

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