psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I85	R:R:V31	4.61	No	No	0	8	7
2	R:R:I85	R:R:L34	5.71	No	No	1	8	8
3	R:R:L34	R:R:W455	20.5	No	Yes	1	8	9
4	R:R:C38	R:R:M81	4.86	No	Yes	0	9	9
5	R:R:C38	R:R:P82	5.65	No	No	0	9	9
6	R:R:T41	R:R:T462	10.99	No	No	0	9	9
7	R:R:L74	R:R:V42	4.47	No	No	0	8	6
8	R:R:D73	R:R:N45	8.08	Yes	No	0	9	9
9	R:R:L74	R:R:N45	5.49	No	No	0	8	9
10	R:R:N45	R:R:P465	6.52	No	No	0	9	9
11	R:R:L46	R:R:L74	8.3	No	No	0	8	8
12	R:R:F479	R:R:L47	6.09	No	No	0	9	9
13	R:R:S70	R:R:V48	8.08	No	No	0	9	9
14	R:R:F479	R:R:V48	3.93	No	No	0	9	9
15	R:R:L49	R:R:S70	4.5	No	No	0	8	9
16	R:R:L49	R:R:V71	4.47	No	No	0	8	6
17	R:R:R53	R:R:Y50	8.23	No	No	3	6	5
18	R:R:S54	R:R:Y50	10.17	No	No	3	7	5
19	R:R:V52	R:R:V67	4.81	No	No	0	8	8
20	R:R:R53	R:R:S54	3.95	No	No	3	6	7
21	R:R:E55	R:R:K57	8.1	Yes	No	0	8	7
22	R:R:E55	R:R:L58	6.63	Yes	Yes	2	8	9
23	R:R:E55	R:R:T478	14.11	Yes	Yes	2	8	8
24	R:R:E55	R:R:R481	9.3	Yes	No	2	8	6
25	R:R:H59	R:R:R56	13.54	No	No	0	8	8
26	R:R:K57	R:R:N474	19.58	No	Yes	0	7	9
27	R:R:L58	R:R:N63	4.12	Yes	No	2	9	9
28	R:R:L58	R:R:N474	4.12	Yes	Yes	0	9	9
29	R:R:F475	R:R:L58	4.87	Yes	Yes	2	9	9
30	R:R:L58	R:R:T478	7.37	Yes	Yes	2	9	8
31	R:R:N63	R:R:T60	5.85	No	No	0	9	9
32	R:R:R139	R:R:V61	5.23	Yes	No	0	9	9
33	R:R:F475	R:R:N63	12.08	Yes	No	2	9	9
34	R:R:A144	R:R:L64	4.73	No	No	0	9	8
35	R:R:I120	R:R:Y65	7.25	No	Yes	0	8	8
36	R:R:L121	R:R:Y65	5.86	No	Yes	0	9	8
37	R:R:D124	R:R:Y65	11.49	No	Yes	0	9	8
38	R:R:A144	R:R:Y65	4	No	Yes	0	9	8
39	R:R:I66	R:R:P469	5.08	No	No	2	9	9
40	R:R:F475	R:R:I66	5.02	Yes	No	2	9	9
41	R:R:S117	R:R:S68	4.89	No	No	0	8	9
42	R:R:I148	R:R:S68	6.19	No	No	0	9	9
43	R:R:S68	R:R:W152	6.18	No	No	0	9	9
44	R:R:D73	R:R:L69	5.43	Yes	Yes	1	9	9
45	R:R:L69	R:R:S117	4.5	Yes	No	0	9	8
46	R:R:L69	R:R:V118	4.47	Yes	Yes	1	9	9
47	R:R:L69	R:R:N464	10.98	Yes	Yes	1	9	9
48	R:R:L69	R:R:Y468	4.69	Yes	Yes	1	9	9
49	R:R:D73	R:R:S114	4.42	Yes	No	0	9	9
50	R:R:D73	R:R:S461	11.78	Yes	No	0	9	9
51	R:R:D73	R:R:N464	8.08	Yes	Yes	1	9	9
52	R:R:S461	R:R:V76	6.46	No	No	0	9	9
53	R:R:G77	R:R:M81	5.24	No	Yes	0	9	9
54	R:R:F102	R:R:V79	3.93	Yes	No	4	8	6
55	R:R:M106	R:R:V79	6.09	No	No	4	8	6
56	R:R:D107	R:R:V80	10.22	No	No	1	9	9
57	R:R:V80	R:R:Y458	5.05	No	Yes	1	9	9
58	R:R:M81	R:R:W455	4.65	Yes	Yes	0	9	9
59	R:R:M81	R:R:Y458	11.97	Yes	Yes	0	9	9
60	R:R:F102	R:R:M83	4.98	Yes	No	0	8	8
61	R:R:M83	R:R:W103	10.47	No	Yes	0	8	9
62	R:R:L88	R:R:N84	4.12	No	Yes	1	8	8
63	R:R:N84	R:R:W103	6.78	Yes	Yes	1	8	9
64	R:R:M451	R:R:N84	5.61	No	Yes	1	6	8
65	R:R:N84	R:R:W455	5.65	Yes	Yes	1	8	9
66	R:R:N84	R:R:Y458	4.65	Yes	Yes	1	8	9
67	R:R:I85	R:R:W455	4.7	No	Yes	1	8	9
68	R:R:L86	R:R:L95	4.15	No	No	0	6	9
69	R:R:W93	R:R:Y87	3.86	Yes	No	0	9	7
70	R:R:K179	R:R:Y87	8.36	No	No	0	4	7
71	R:R:L88	R:R:M451	5.65	No	No	1	8	6
72	R:R:D178	R:R:K92	9.68	No	No	0	3	2
73	R:R:L95	R:R:W93	5.69	No	Yes	0	9	9
74	R:R:C100	R:R:W93	7.84	No	Yes	1	9	9
75	R:R:W103	R:R:W93	7.5	Yes	Yes	1	9	9
76	R:R:C180	R:R:W93	11.75	No	Yes	1	9	9
77	R:R:L95	R:R:L99	6.92	No	No	0	9	7
78	R:R:L101	R:R:R97	10.93	No	Yes	0	8	5
79	R:R:R175	R:R:R97	18.13	No	Yes	1	4	5
80	R:R:D183	R:R:R97	5.96	Yes	Yes	1	7	5
81	R:R:F102	R:R:L99	4.87	Yes	No	0	8	7
82	R:R:C100	R:R:C180	7.28	No	No	1	9	9
83	R:R:L101	R:R:L163	5.54	No	No	0	8	7
84	R:R:F102	R:R:M106	6.22	Yes	No	4	8	8
85	R:R:L104	R:R:W103	5.69	No	Yes	0	9	9
86	R:R:C180	R:R:W103	5.22	No	Yes	1	9	9
87	R:R:L104	R:R:T182	4.42	No	Yes	0	9	9
88	R:R:S105	R:R:V159	6.46	No	No	0	9	5
89	R:R:D107	R:R:Y458	11.49	No	Yes	1	9	9
90	L:L:?1	R:R:D107	10.22	Yes	No	1	0	9
91	R:R:W158	R:R:Y108	11.58	Yes	Yes	1	8	9
92	R:R:I162	R:R:Y108	6.04	No	Yes	0	9	9
93	R:R:T182	R:R:Y108	6.24	Yes	Yes	0	9	9
94	L:L:?1	R:R:Y108	16.55	Yes	Yes	1	0	9
95	R:R:F156	R:R:V109	10.49	No	No	0	5	9
96	R:R:S111	R:R:W428	4.94	No	Yes	0	9	9
97	L:L:?1	R:R:S111	14.13	Yes	No	0	0	9
98	R:R:F116	R:R:T112	7.78	No	Yes	0	8	9
99	R:R:S155	R:R:T112	7.99	No	Yes	0	9	9
100	R:R:T112	R:R:W158	9.7	Yes	Yes	1	9	8
101	R:R:N198	R:R:T112	10.24	Yes	Yes	1	9	9
102	R:R:A113	R:R:W152	7.78	No	No	0	9	9
103	R:R:I115	R:R:N198	7.08	No	Yes	0	9	9
104	R:R:I115	R:R:W428	9.4	No	Yes	0	9	9
105	R:R:M206	R:R:V118	4.56	No	Yes	1	9	9
106	R:R:F424	R:R:V118	3.93	Yes	Yes	1	9	9
107	R:R:N464	R:R:V118	4.43	Yes	Yes	1	9	9
108	R:R:V118	R:R:Y468	8.83	Yes	Yes	1	9	9
109	R:R:F119	R:R:I123	8.79	No	No	0	8	6
110	R:R:F119	R:R:L205	7.31	No	No	0	8	6
111	R:R:I120	R:R:T147	4.56	No	No	0	8	8
112	R:R:L121	R:R:R125	4.86	No	No	1	9	9
113	R:R:L121	R:R:Y468	7.03	No	Yes	1	9	9
114	R:R:C122	R:R:M206	6.48	No	No	0	8	9
115	R:R:C122	R:R:Y210	8.06	No	Yes	0	8	9
116	R:R:D124	R:R:R139	5.96	No	Yes	0	9	9
117	R:R:R125	R:R:Y210	6.17	No	Yes	0	9	9
118	R:R:R125	R:R:Y468	4.12	No	Yes	1	9	9
119	R:R:Q130	R:R:Y126	9.02	No	No	0	8	9
120	R:R:F209	R:R:Y126	14.44	Yes	No	0	7	9
121	R:R:R127	R:R:Y135	12.35	No	No	0	8	9
122	R:R:R139	R:R:S128	6.59	Yes	No	0	9	9
123	R:R:Q131	R:R:R134	12.85	No	No	0	7	5
124	R:R:R139	R:R:Y135	12.35	Yes	No	0	9	9
125	R:R:K137	R:R:Y138	11.94	No	No	0	5	8
126	R:R:R143	R:R:Y138	6.17	No	No	0	9	8
127	R:R:F184	R:R:W158	4.01	Yes	Yes	1	9	8
128	R:R:T194	R:R:W158	8.49	No	Yes	0	8	8
129	R:R:N198	R:R:W158	4.52	Yes	Yes	1	9	8
130	L:L:?1	R:R:W158	4.29	Yes	Yes	1	0	8
131	R:R:L163	R:R:V159	4.47	No	No	0	7	5
132	R:R:I160	R:R:P161	6.77	No	No	0	8	9
133	R:R:F190	R:R:P161	7.22	Yes	No	0	9	9
134	R:R:D183	R:R:W165	5.58	Yes	Yes	1	7	9
135	R:R:F184	R:R:W165	9.02	Yes	Yes	1	9	9
136	R:R:V187	R:R:W165	7.36	No	Yes	0	8	9
137	R:R:F190	R:R:W165	4.01	Yes	Yes	1	9	9
138	R:R:D183	R:R:N166	9.42	Yes	No	0	7	6
139	R:R:D183	R:R:R175	5.96	Yes	No	1	7	4
140	R:R:K179	R:R:R176	11.14	No	No	0	4	1
141	R:R:E447	R:R:K179	5.4	No	No	0	4	4
142	R:R:E181	R:R:T182	7.06	No	Yes	0	7	9
143	R:R:E181	R:R:Y185	12.35	No	No	0	7	7
144	R:R:F184	R:R:T182	18.16	Yes	Yes	0	9	9
145	R:R:F184	R:R:F190	15	Yes	Yes	1	9	9
146	R:R:N443	R:R:Y185	8.14	No	No	0	4	7
147	R:R:D186	R:R:N443	4.04	No	No	0	3	4
148	R:R:V187	R:R:W189	6.13	No	No	0	8	5
149	R:R:F440	R:R:T188	3.89	No	No	0	7	8
150	R:R:F190	R:R:W189	5.01	Yes	No	0	9	5
151	R:R:F190	R:R:T194	7.78	Yes	No	0	9	8
152	R:R:F435	R:R:K191	23.58	Yes	No	0	8	9
153	R:R:I438	R:R:K191	5.82	No	No	0	6	9
154	R:R:A439	R:R:K191	6.42	No	No	0	8	9
155	R:R:F435	R:R:T194	5.19	Yes	No	0	8	8
156	R:R:F432	R:R:N198	9.67	Yes	Yes	1	9	9
157	L:L:?1	R:R:N198	5.17	Yes	Yes	1	0	9
158	R:R:F199	R:R:Y200	6.19	Yes	No	0	9	8
159	R:R:F199	R:R:T203	12.97	Yes	No	0	9	9
160	R:R:F199	R:R:F424	8.57	Yes	Yes	1	9	9
161	R:R:F199	R:R:W428	7.02	Yes	Yes	1	9	9
162	R:R:F199	R:R:F432	12.86	Yes	Yes	1	9	9
163	R:R:M436	R:R:Y200	7.18	No	No	0	7	8
164	R:R:F424	R:R:M206	7.46	Yes	No	1	9	9
165	R:R:L207	R:R:M421	5.65	No	No	0	7	9
166	R:R:F209	R:R:W208	4.01	Yes	No	0	7	4
167	R:R:K212	R:R:W208	4.64	No	No	0	5	4
168	R:R:L417	R:R:Y210	7.03	No	Yes	0	9	9
169	R:R:I420	R:R:Y210	6.04	Yes	Yes	0	9	9
170	R:R:A414	R:R:Y214	4	No	No	0	9	8
171	R:R:E410	R:R:R218	9.3	Yes	No	0	8	7
172	R:R:C221	R:R:R409	5.57	No	No	0	5	8
173	R:R:C221	R:R:E410	6.08	No	Yes	0	5	8
174	R:R:I420	R:R:Q416	4.12	Yes	No	0	9	9
175	R:R:C471	R:R:Q416	9.16	No	No	0	9	9
176	R:R:F419	R:R:I467	6.28	No	No	0	7	9
177	R:R:I420	R:R:I467	4.42	Yes	No	0	9	9
178	R:R:I420	R:R:Y468	4.84	Yes	Yes	0	9	9
179	R:R:F424	R:R:W428	4.01	Yes	Yes	1	9	9
180	R:R:I425	R:R:I429	4.42	No	Yes	0	8	8
181	R:R:C427	R:R:N460	6.3	No	No	0	9	9
182	R:R:W428	R:R:Y431	4.82	Yes	Yes	1	9	9
183	R:R:F432	R:R:W428	4.01	Yes	Yes	1	9	9
184	R:R:G457	R:R:W428	8.44	No	Yes	0	9	9
185	R:R:N460	R:R:W428	13.56	No	Yes	0	9	9
186	R:R:I429	R:R:P430	5.08	Yes	No	0	8	9
187	R:R:I429	R:R:I433	4.42	Yes	No	0	8	7
188	R:R:F432	R:R:Y431	7.22	Yes	Yes	1	9	9
189	R:R:F435	R:R:Y431	8.25	Yes	Yes	1	8	9
190	R:R:T453	R:R:Y431	8.74	No	Yes	0	9	9
191	R:R:I454	R:R:Y431	4.84	No	Yes	0	8	9
192	L:L:?1	R:R:Y431	16.55	Yes	Yes	1	0	9
193	R:R:F434	R:R:I438	16.33	No	No	0	7	6
194	R:R:F434	R:R:L449	7.31	No	No	0	7	4
195	R:R:F434	R:R:H450	19.23	No	No	0	7	7
196	L:L:?1	R:R:F435	4.59	Yes	Yes	1	0	8
197	R:R:C441	R:R:C444	7.28	No	No	0	7	5
198	R:R:H448	R:R:N446	8.93	No	No	0	2	6
199	R:R:H450	R:R:I454	9.28	No	No	0	7	8
200	R:R:F452	R:R:L456	8.53	No	No	0	5	9
201	R:R:I454	R:R:Y458	8.46	No	Yes	0	8	9
202	L:L:?1	R:R:Y458	4.41	Yes	Yes	1	0	9
203	R:R:N460	R:R:N464	6.81	No	Yes	0	9	9
204	R:R:N464	R:R:Y468	4.65	Yes	Yes	1	9	9
205	R:R:F475	R:R:P469	10.11	Yes	No	2	9	9
206	R:R:N472	R:R:N474	6.81	No	Yes	0	9	9
207	R:R:F475	R:R:N472	7.25	Yes	No	0	9	9
208	R:R:F475	R:R:F479	5.36	Yes	No	0	9	9
209	R:R:K477	R:R:R481	6.19	No	No	0	7	6
210	R:R:R481	R:R:T478	3.88	No	Yes	2	6	8
211	R:R:F209	R:R:I123	3.77	Yes	No	0	7	6
212	R:R:F199	R:R:I429	3.77	Yes	Yes	0	9	8
213	R:R:K215	R:R:R218	3.71	No	No	0	6	7
214	R:R:H220	R:R:Q219	3.71	No	No	0	8	5
215	R:R:G43	R:R:V42	3.68	No	No	0	6	6
216	R:R:V71	R:R:W152	3.68	No	No	0	6	9
217	R:R:G77	R:R:T41	3.64	No	No	0	9	9
218	R:R:C441	R:R:C445	3.64	No	No	0	7	5
219	R:R:I482	R:R:Y50	3.63	No	No	0	8	5
220	R:R:I213	R:R:Y126	3.63	No	No	0	9	9
221	R:R:M421	R:R:Y210	3.59	No	Yes	0	9	9
222	R:R:A72	R:R:S114	3.42	No	No	0	9	9
223	R:R:A110	R:R:V76	3.39	No	No	0	8	9
224	R:R:A413	R:R:V217	3.39	No	No	0	9	9
225	R:R:E410	R:R:Y214	3.37	Yes	No	0	8	8
226	R:R:A51	R:R:T478	3.36	No	Yes	0	9	8
227	R:R:L44	R:R:P465	3.28	No	No	0	9	9
228	R:R:L201	R:R:P202	3.28	No	No	0	7	9
229	R:R:L456	R:R:P430	3.28	No	No	0	9	9
230	R:R:C445	R:R:I438	3.27	No	No	0	5	6
231	R:R:A110	R:R:I75	3.25	No	No	0	8	8
232	R:R:A151	R:R:I120	3.25	No	No	0	7	8
233	R:R:S155	R:R:V109	3.23	No	No	0	9	9
234	R:R:A195	R:R:M436	3.22	No	No	0	9	7
235	R:R:M90	R:R:S94	3.07	No	No	0	5	5
236	R:R:K92	R:R:S94	3.06	No	No	0	2	5
237	R:R:I37	R:R:T462	3.04	No	No	0	7	9
238	R:R:M436	R:R:V192	3.04	No	No	0	7	8
239	R:R:L89	R:R:V31	2.98	No	No	0	6	7
240	R:R:L44	R:R:V40	2.98	No	No	0	9	4
241	R:R:L49	R:R:V67	2.98	No	No	0	8	8
242	R:R:F119	R:R:P202	2.89	No	No	0	8	9
243	R:R:P98	R:R:R97	2.88	No	Yes	0	5	5
244	R:R:K476	R:R:K480	2.87	No	No	0	8	8
245	R:R:I160	R:R:L157	2.85	No	No	0	8	5
246	R:R:I459	R:R:L463	2.85	No	No	0	6	8
247	R:R:L86	R:R:M90	2.83	No	No	0	6	5
248	R:R:L89	R:R:M90	2.83	No	No	0	6	5
249	R:R:G96	R:R:W93	2.81	No	Yes	0	8	9
250	R:R:C122	R:R:F209	2.79	No	Yes	0	8	7
251	R:R:L44	R:R:L466	2.77	No	No	0	9	7
252	R:R:L466	R:R:L470	2.77	No	No	0	7	8
253	R:R:F116	R:R:L154	2.44	No	No	0	8	7
254	R:R:L417	R:R:Y214	2.34	No	No	0	9	8
255	R:R:G62	R:R:T60	1.82	No	No	0	8	9
256	R:R:C221	R:R:V217	1.71	No	No	0	5	9
257	R:R:G418	R:R:L417	1.71	No	No	0	8	9
258	R:R:C445	R:R:V437	1.71	No	No	0	5	8
259	R:R:A78	R:R:V42	1.7	No	No	0	7	6
260	R:R:A78	R:R:V79	1.7	No	No	0	7	6
261	R:R:A216	R:R:V129	1.7	No	No	0	6	9
262	R:R:S35	R:R:V31	1.62	No	No	0	7	7
263	R:R:A423	R:R:I467	1.62	No	No	0	8	9
264	R:R:T36	R:R:V40	1.59	No	No	0	5	4
265	R:R:G164	R:R:H167	1.59	No	No	0	7	4
266	R:R:P132	R:R:Q131	1.58	No	No	0	9	7
267	R:R:A422	R:R:L426	1.58	No	No	0	8	5
268	R:R:T140	R:R:T142	1.57	No	No	0	9	6
269	R:R:I37	R:R:V33	1.54	No	No	0	7	4
270	R:R:I196	R:R:V192	1.54	No	No	0	7	8
271	R:R:K141	R:R:V61	1.52	No	No	0	8	9
272	R:R:A216	R:R:Q130	1.52	No	No	0	6	8
273	R:R:I482	R:R:T478	1.52	No	Yes	0	8	8
274	R:R:F153	R:R:G150	1.51	No	No	0	5	5
275	R:R:L64	R:R:S145	1.5	No	No	0	8	6
276	R:R:K442	R:R:T188	1.5	No	No	0	3	8
277	R:R:I37	R:R:I459	1.47	No	No	0	7	6
278	R:R:I197	R:R:M193	1.46	No	No	0	5	7
279	R:R:H59	R:R:V52	1.38	No	No	0	8	8
280	R:R:D186	R:R:K442	1.38	No	No	0	3	3
281	R:R:L204	R:R:L207	1.38	No	No	0	5	7
282	R:R:E447	R:R:N446	1.31	No	No	0	4	6
283	R:R:E473	R:R:N474	1.31	No	Yes	0	5	9
284	R:R:D178	R:R:E177	1.3	No	No	0	3	3
285	R:R:R143	R:R:T140	1.29	No	No	0	9	9
286	R:R:Q130	R:R:Q131	1.28	No	No	0	8	7
287	R:R:H167	R:R:N166	1.28	No	No	0	4	6
288	R:R:E410	R:R:Q222	1.27	Yes	No	0	8	7
289	R:R:L136	R:R:R139	1.21	No	Yes	0	8	9
290	R:R:N408	R:R:R411	1.21	No	No	0	7	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:E55	9.535	4	2	8
2	R:R:L58	5.422	5	2	9
3	R:R:Y65	7.15	4	0	8
4	R:R:L69	6.014	5	1	9
5	R:R:D73	7.558	5	1	9
6	R:R:M81	6.68	4	0	9
7	R:R:N84	5.362	5	1	8
8	R:R:W93	6.575	6	1	9
9	R:R:R97	9.475	4	1	5
10	R:R:F102	5	4	4	8
11	R:R:W103	7.132	5	1	9
12	R:R:Y108	10.1025	4	1	9
13	R:R:T112	8.9275	4	1	9
14	R:R:V118	5.244	5	1	9
15	R:R:R139	6.268	5	0	9
16	R:R:W158	7.09833	6	1	8
17	R:R:W165	6.4925	4	1	9
18	R:R:T182	8.97	4	0	9
19	R:R:D183	6.73	4	1	7
20	R:R:F184	11.5475	4	1	9
21	R:R:F190	7.804	5	1	9
22	R:R:N198	7.336	5	1	9
23	R:R:F199	8.56333	6	1	9
24	R:R:F209	6.2525	4	0	7
25	R:R:Y210	6.178	5	0	9
26	R:R:E410	5.005	4	0	8
27	R:R:I420	4.855	4	0	9
28	R:R:F424	5.9925	4	1	9
29	R:R:W428	7.025	8	1	9
30	R:R:I429	4.4225	4	0	8
31	R:R:Y431	8.40333	6	1	9
32	R:R:F432	8.44	4	1	9
33	R:R:F435	10.4025	4	1	8
34	R:R:W455	8.875	4	1	9
35	R:R:Y458	7.67167	6	1	9
36	R:R:N464	6.99	5	1	9
37	R:R:Y468	5.69333	6	1	9
38	R:R:N474	7.955	4	0	9
39	R:R:F475	7.44833	6	2	9
40	R:R:T478	6.048	5	2	8
41	L:L:?1	9.48875	8	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:M81	R:R:W455	21.0332	4.65	Yes	Yes	0	9	9
2	R:R:I85	R:R:W455	31.8465	4.7	No	Yes	1	8	9
3	R:R:G77	R:R:M81	18.0221	5.24	No	Yes	0	9	9
4	R:R:G77	R:R:T41	15.4663	3.64	No	No	0	9	9
5	R:R:T41	R:R:T462	12.9041	10.99	No	No	0	9	9
6	R:R:N84	R:R:W455	21.7002	5.65	Yes	Yes	1	8	9
7	R:R:N84	R:R:W103	41.0275	6.78	Yes	Yes	1	8	9
8	R:R:D73	R:R:N464	19.9718	8.08	Yes	Yes	1	9	9
9	R:R:N460	R:R:N464	72.3256	6.81	No	Yes	0	9	9
10	R:R:N460	R:R:W428	73.6852	13.56	No	Yes	0	9	9
11	R:R:S111	R:R:W428	48.8872	4.94	No	Yes	0	9	9
12	L:L:?1	R:R:S111	48.6596	14.13	Yes	No	0	0	9
13	L:L:?1	R:R:Y458	75.7311	4.41	Yes	Yes	1	0	9
14	R:R:M81	R:R:Y458	44.0675	11.97	Yes	Yes	0	9	9
15	R:R:W428	R:R:Y431	100	4.82	Yes	Yes	1	9	9
16	L:L:?1	R:R:Y431	52.7065	16.55	Yes	Yes	1	0	9
17	R:R:I454	R:R:Y431	37.1665	4.84	No	Yes	0	8	9
18	R:R:I454	R:R:Y458	35.9768	8.46	No	Yes	0	8	9
19	R:R:N84	R:R:Y458	64.8826	4.65	Yes	Yes	1	8	9
20	R:R:D73	R:R:N45	21.0749	8.08	Yes	No	0	9	9
21	R:R:L74	R:R:N45	11.9388	5.49	No	No	0	8	9
22	R:R:F479	R:R:V48	59.8865	3.93	No	No	0	9	9
23	R:R:S70	R:R:V48	61.9709	8.08	No	No	0	9	9
24	R:R:L49	R:R:S70	64.0489	4.5	No	No	0	8	9
25	R:R:L49	R:R:V71	74.2977	4.47	No	No	0	8	6
26	R:R:V71	R:R:W152	76.3276	3.68	No	No	0	6	9
27	R:R:S68	R:R:W152	80.3681	6.18	No	No	0	9	9
28	R:R:S117	R:R:S68	84.383	4.89	No	No	0	8	9
29	R:R:L69	R:R:S117	86.3808	4.5	Yes	No	0	9	8
30	R:R:L69	R:R:V118	44.2342	4.47	Yes	Yes	1	9	9
31	R:R:F424	R:R:V118	68.5159	3.93	Yes	Yes	1	9	9
32	R:R:F424	R:R:W428	93.3812	4.01	Yes	Yes	1	9	9
33	R:R:L69	R:R:N464	34.8288	10.98	Yes	Yes	1	9	9
34	R:R:F475	R:R:F479	56.1089	5.36	Yes	No	0	9	9
35	R:R:F475	R:R:L58	34.9667	4.87	Yes	Yes	2	9	9
36	R:R:L58	R:R:T478	17.6597	7.37	Yes	Yes	2	9	8
37	R:R:V118	R:R:Y468	26.4206	8.83	Yes	Yes	1	9	9
38	R:R:L121	R:R:Y468	39.3439	7.03	No	Yes	1	9	9
39	R:R:L121	R:R:Y65	38.6769	5.86	No	Yes	0	9	8
40	R:R:D124	R:R:Y65	20.6228	11.49	No	Yes	0	9	8
41	R:R:D124	R:R:R139	18.0124	5.96	No	Yes	0	9	9
42	R:R:N464	R:R:Y468	28.4505	4.65	Yes	Yes	1	9	9
43	R:R:I85	R:R:V31	27.0908	4.61	No	No	0	8	7
44	R:R:L89	R:R:V31	17.6469	2.98	No	No	0	6	7
45	R:R:L89	R:R:M90	13.2632	2.83	No	No	0	6	5
46	R:R:L86	R:R:L95	11.384	4.15	No	No	0	6	9
47	R:R:W103	R:R:W93	32.5359	7.5	Yes	Yes	1	9	9
48	R:R:L95	R:R:W93	12.0062	5.69	No	Yes	0	9	9
49	R:R:W93	R:R:Y87	15.1199	3.86	Yes	No	0	9	7
50	R:R:K179	R:R:Y87	12.5705	8.36	No	No	0	4	7
51	R:R:K92	R:R:S94	13.2055	3.06	No	No	0	2	5
52	R:R:M90	R:R:S94	17.5956	3.07	No	No	0	5	5
53	L:L:?1	R:R:W158	22.4602	4.29	Yes	Yes	1	0	8
54	R:R:F184	R:R:W158	42.8361	4.01	Yes	Yes	1	9	8
55	R:R:F184	R:R:W165	40.0526	9.02	Yes	Yes	1	9	9
56	R:R:D183	R:R:W165	41.4636	5.58	Yes	Yes	1	7	9
57	R:R:D183	R:R:R97	22.6751	5.96	Yes	Yes	1	7	5
58	R:R:L101	R:R:R97	15.152	10.93	No	Yes	0	8	5
59	R:R:L101	R:R:L163	11.3391	5.54	No	No	0	8	7
60	L:L:?1	R:R:Y108	15.8286	16.55	Yes	Yes	1	0	9
61	R:R:N198	R:R:T112	11.4065	10.24	Yes	Yes	1	9	9
62	R:R:I115	R:R:N198	13.6512	7.08	No	Yes	0	9	9
63	R:R:F424	R:R:M206	37.4615	7.46	Yes	No	1	9	9
64	R:R:C122	R:R:F209	25.2245	2.79	No	Yes	0	8	7
65	R:R:C122	R:R:M206	41.7041	6.48	No	No	0	8	9
66	R:R:C122	R:R:Y210	19.3529	8.06	No	Yes	0	8	9
67	R:R:F209	R:R:Y126	12.7052	14.44	Yes	No	0	7	9
68	R:R:F435	R:R:T194	14.1002	5.19	Yes	No	0	8	8
69	R:R:F190	R:R:T194	14.0425	7.78	Yes	No	0	9	8
70	R:R:D183	R:R:N166	11.4482	9.42	Yes	No	0	7	6
71	R:R:E181	R:R:T182	12.7597	7.06	No	Yes	0	7	9
72	R:R:E181	R:R:Y185	10.9223	12.35	No	No	0	7	7
73	R:R:F432	R:R:N198	26.1897	9.67	Yes	Yes	1	9	9
74	R:R:F199	R:R:W428	10.7908	7.02	Yes	Yes	1	9	9
75	R:R:F199	R:R:F432	19.401	12.86	Yes	Yes	1	9	9
76	R:R:F199	R:R:Y200	11.0922	6.19	Yes	No	0	9	8
77	R:R:L417	R:R:Y210	21.1711	7.03	No	Yes	0	9	9
78	R:R:I420	R:R:Y468	19.308	4.84	Yes	Yes	0	9	9
79	R:R:L417	R:R:Y214	17.7142	2.34	No	No	0	9	8
80	R:R:E410	R:R:Y214	14.2605	3.37	Yes	No	0	8	8
81	R:R:F199	R:R:I429	13.446	3.77	Yes	Yes	0	9	8
82	R:R:I37	R:R:T462	10.3354	3.04	No	No	0	7	9
83	R:R:T182	R:R:Y108	14.5171	6.24	Yes	Yes	0	9	9
84	R:R:D73	R:R:L69	11.1564	5.43	Yes	Yes	1	9	9
85	R:R:L69	R:R:Y468	12.0735	4.69	Yes	Yes	1	9	9
86	R:R:N198	R:R:W158	24.9262	4.52	Yes	Yes	1	9	8
87	R:R:I115	R:R:W428	13.9174	9.4	No	Yes	0	9	9
88	R:R:F432	R:R:W428	13.8116	4.01	Yes	Yes	1	9	9
89	R:R:F435	R:R:Y431	18.2465	8.25	Yes	Yes	1	8	9
90	R:R:F199	R:R:F424	13.3145	8.57	Yes	Yes	1	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D107	R:R:V80	10.22	1	No	No	9	9	1	2
R:R:V80	R:R:Y458	5.05	1	No	Yes	9	9	2	1
R:R:M81	R:R:Y458	11.97	0	Yes	Yes	9	9	2	1
R:R:N84	R:R:Y458	4.65	1	Yes	Yes	8	9	2	1
R:R:D107	R:R:Y458	11.49	1	No	Yes	9	9	1	1
L:L:?1	R:R:D107	10.22	1	Yes	No	0	9	0	1
R:R:W158	R:R:Y108	11.58	1	Yes	Yes	8	9	1	1
R:R:I162	R:R:Y108	6.04	0	No	Yes	9	9	2	1
R:R:T182	R:R:Y108	6.24	0	Yes	Yes	9	9	2	1
L:L:?1	R:R:Y108	16.55	1	Yes	Yes	0	9	0	1
R:R:S111	R:R:W428	4.94	0	No	Yes	9	9	1	2
L:L:?1	R:R:S111	14.13	1	Yes	No	0	9	0	1
R:R:T112	R:R:W158	9.7	1	Yes	Yes	9	8	2	1
R:R:N198	R:R:T112	10.24	1	Yes	Yes	9	9	1	2
R:R:I115	R:R:N198	7.08	0	No	Yes	9	9	2	1
R:R:I115	R:R:W428	9.4	0	No	Yes	9	9	2	2
R:R:F184	R:R:W158	4.01	1	Yes	Yes	9	8	2	1
R:R:T194	R:R:W158	8.49	0	No	Yes	8	8	2	1
R:R:N198	R:R:W158	4.52	1	Yes	Yes	9	8	1	1
L:L:?1	R:R:W158	4.29	1	Yes	Yes	0	8	0	1
R:R:F184	R:R:T182	18.16	1	Yes	Yes	9	9	2	2
R:R:F435	R:R:K191	23.58	1	Yes	No	8	9	1	2
R:R:F435	R:R:T194	5.19	1	Yes	No	8	8	1	2
R:R:F432	R:R:N198	9.67	1	Yes	Yes	9	9	2	1
L:L:?1	R:R:N198	5.17	1	Yes	Yes	0	9	0	1
R:R:W428	R:R:Y431	4.82	1	Yes	Yes	9	9	2	1
R:R:F432	R:R:W428	4.01	1	Yes	Yes	9	9	2	2
R:R:F432	R:R:Y431	7.22	1	Yes	Yes	9	9	2	1
R:R:F435	R:R:Y431	8.25	1	Yes	Yes	8	9	1	1
R:R:T453	R:R:Y431	8.74	0	No	Yes	9	9	2	1
R:R:I454	R:R:Y431	4.84	0	No	Yes	8	9	2	1
L:L:?1	R:R:Y431	16.55	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:F435	4.59	1	Yes	Yes	0	8	0	1
R:R:I454	R:R:Y458	8.46	0	No	Yes	8	9	2	1
L:L:?1	R:R:Y458	4.41	1	Yes	Yes	0	9	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9LRD_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.86
Number of Linked Nodes	252
Number of Links	290
Number of Hubs	41
Number of Links mediated by Hubs	148
Number of Communities	4
Number of Nodes involved in Communities	52
Number of Links involved in Communities	76

Path Summary
Number Of Nodes in MetaPath	91
Number Of Links MetaPath	90
Number of Shortest Paths	84645
Length Of Smallest Path	3
Average Path Length	14.3077
Length of Longest Path	30
Minimum Path Strength	1.4
Average Path Strength	6.4542
Maximum Path Strength	17.78
Minimum Path Correlation	0.7
Average Path Correlation	0.919302
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.34783
Average % Of Corr. Nodes	44.3789
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	51.0137
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • protein binding • binding • G-protein beta-subunit binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • cellular process • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • G protein-coupled amine receptor activity • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • histamine receptor activity • regulation of tube diameter • multicellular organismal process • system process • regulation of tube size • regulation of system process • positive regulation of biological process • positive regulation of vasoconstriction • circulatory system process • regulation of blood circulation • vascular process in circulatory system • regulation of vasoconstriction • positive regulation of multicellular organismal process • regulation of multicellular organismal process • blood vessel diameter maintenance • regulation of biological quality • vasoconstriction • blood circulation • regulation of anatomical structure size • phospholipase C-activating G protein-coupled receptor signaling pathway • trans-synaptic signaling • synaptic signaling • anterograde trans-synaptic signaling • cell-cell signaling • chemical synaptic transmission • regulation of synaptic plasticity • regulation of signaling • modulation of chemical synaptic transmission • regulation of trans-synaptic signaling • regulation of cell communication • response to histamine • cellular response to histamine • defense response • response to stress • inflammatory response • regulation of vascular permeability • behavior • learning or memory • nervous system process • cognition • memory • response to light stimulus • learning • visual learning • visual behavior • associative learning • response to radiation • response to abiotic stimulus • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • synapse • cell junction • somatodendritic compartment • dendrite • dendritic tree • neuron projection • cytoskeletal protein binding • spectrin binding • protein-containing complex binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • positive regulation of cytosolic calcium ion concentration • sensory perception of chemical stimulus • sensory perception • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • response to decreased oxygen levels • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to stress • response to hypoxia • response to oxygen levels • cell population proliferation • muscle cell apoptotic process • striated muscle cell apoptotic process • apoptotic process • cell death • programmed cell death • cardiac muscle cell apoptotic process • photoreceptor inner segment • non-motile cilium • 9+0 non-motile cilium • photoreceptor outer segment • photoreceptor cell cilium • ciliary membrane • photoreceptor outer segment membrane • plasma membrane region • cell projection membrane • cell body
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	HSM
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	HSM
Name	Histamine
Synonyms	1H-Imidazole-4-ethanamine
Identifier
Formula	C5 H9 N3
Molecular Weight	111.145
SMILES
PubChem	774
Formal Charge	0
Total Atoms	17
Total Chiral Atoms	0
Total Bonds	17
Total Aromatic Bonds	5


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P35367
Sequence	>9LRD_nogp_Chain_R P L V V V L S T I C L V T V G L N L L V L Y A V R S E R K L H T V G N L Y I V S L S V A D L I V G A V V M P M N I L Y L L M S K W S L G R P L C L F W L S M D Y V A S T A S I F S V F I L C I D R Y R S V Q Q P L R Y L K Y R T K T R A S A T I L G A W F L S F L W V I P I L G W N H F R R E D K C E T D F Y D V T W F K V M T A I I N F Y L P T L L M L W F Y A K I Y K A V R Q H C Q H N R E R K A A K Q L G F I M A A F I L C W I P Y F I F F M V I A F C K N C C N E H L H M F T I W L G Y I N S T L N P L I Y P L C N E N F K K T F K R I Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8GH1	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	4.1	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	2RH1	A	Amine	Adrenergic	β₂	Homo sapiens	S-Carazolol	-	-	2.4	2007-10-30	doi.org/10.1126/science.1150577
	3RZE	A	Amine	Histamine	H₁	Homo sapiens	Cidoxepin	-	-	3.1	2011-06-15	doi.org/10.1038/nature10236
	7DFL	A	Amine	Histamine	H₁	Homo sapiens	Histamine	-	chim(NtGi1L-Gq)/β1/γ2	3.3	2021-03-31	doi.org/10.1038/s41467-021-22427-2
	7DFL (No Gprot)	A	Amine	Histamine	H₁	Homo sapiens	Histamine	-		3.3	2021-03-31	doi.org/10.1038/s41467-021-22427-2
	8X5X	A	Amine	Histamine	H₁	Homo sapiens	-	-	-	3.5	2024-01-17	doi.org/10.1038/s41467-023-44477-4
	8X5Y	A	Amine	Histamine	H₁	Homo sapiens	Astemizole	-	-	3	2024-01-17	doi.org/10.1038/s41467-023-44477-4
	8X63	A	Amine	Histamine	H₁	Homo sapiens	Mepyramine	-	-	3.2	2024-01-17	doi.org/10.1038/s41467-023-44477-4
	8X64	A	Amine	Histamine	H₁	Homo sapiens	Desloratadine	-	-	3.4	2024-01-17	doi.org/10.1038/s41467-023-44477-4
	8YN2	A	Amine	Histamine	H₁	Homo sapiens	Histamine	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.66	2024-10-09	doi.org/10.1038/s41467-024-52585-y
	8YN2 (No Gprot)	A	Amine	Histamine	H₁	Homo sapiens	Histamine	-		2.66	2024-10-09	doi.org/10.1038/s41467-024-52585-y
	9LRD	A	Amine	Histamine	H₁	Homo sapiens	Histamine	-	Gi1/β1/γ2	3.23	2025-06-11	To be published
	9LRD (No Gprot)	A	Amine	Histamine	H₁	Homo sapiens	Histamine	-		3.23	2025-06-11	To be published
	9LRB	A	Amine	Histamine	H₁	Homo sapiens	Histamine	-	Gs/β1/γ2	2.77	2025-06-11	To be published
	9LRB (No Gprot)	A	Amine	Histamine	H₁	Homo sapiens	Histamine	-		2.77	2025-06-11	To be published
	8WSS	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	Pro-MCH	-	Gi1/β1/γ1	3.01	2024-06-19	doi.org/10.1038/s41421-024-00679-8
	8WSS (No Gprot)	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	Pro-MCH	-		3.01	2024-06-19	doi.org/10.1038/s41421-024-00679-8
	8YNS	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	SNAP-94847	-	-	3.33	2024-12-18	doi.org/10.1038/s41421-024-00754-0
	8YNT	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	SNAP-94847	-	-	3.43	2024-12-18	doi.org/10.1038/s41421-024-00754-0
	8WWK	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	MCH	-	Gi1/β1/γ2	2.61	2024-11-13	doi.org/10.1038/s41421-024-00754-0
	8WWK (No Gprot)	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	MCH	-		2.61	2024-11-13	doi.org/10.1038/s41421-024-00754-0
	8WWL	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	MCH	-	Gi1/β1/γ2	2.78	2024-11-13	doi.org/10.1038/s41421-024-00754-0
	8WWL (No Gprot)	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	MCH	-		2.78	2024-11-13	doi.org/10.1038/s41421-024-00754-0
	8WWM	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	MCH	-	Gi1/β1/γ2	2.81	2024-11-13	doi.org/10.1038/s41421-024-00754-0
	8WWM (No Gprot)	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	MCH	-		2.81	2024-11-13	doi.org/10.1038/s41421-024-00754-0
	8WWN	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	MCH	-	Gi1/β1/γ2	2.65	2024-11-13	doi.org/10.1038/s41421-024-00754-0
	8WWN (No Gprot)	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	MCH	-		2.65	2024-11-13	doi.org/10.1038/s41421-024-00754-0
	8WWH	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	-	-	Gi1/β1/γ2	2.84	2024-11-13	To be published
	8WWH (No Gprot)	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	-	-		2.84	2024-11-13	To be published
	8WWI	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	-	-	Gi1/β1/γ2	3.43	2024-11-13	To be published
	8WWI (No Gprot)	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	-	-		3.43	2024-11-13	To be published
	8WWJ	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	-	-	Gi1/β1/γ2	3.03	2024-11-13	To be published
	8WWJ (No Gprot)	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	-	-		3.03	2024-11-13	To be published
	8GW8	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	-	PCO371	Gs/β1/γ2	2.9	2023-06-14	doi.org/10.1038/s41586-023-06169-3
	8GW8 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	-	PCO371		2.9	2023-06-14	doi.org/10.1038/s41586-023-06169-3
	8JR9	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	-	PCO371	chim(NtGi1-Gs)/β1/γ2	2.57	2023-08-02	doi.org/10.1038/s41586-023-06467-w
	8JR9 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	-	PCO371		2.57	2023-08-02	doi.org/10.1038/s41586-023-06467-w
	7VVJ	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-	Gs/β1/γ2	3.2	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVJ (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-		3.2	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVK	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	3.3	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVK (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		3.3	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVL	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	2.8	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVL (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.8	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVM	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	3.2	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVM (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		3.2	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVN	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	3.8	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVN (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		3.8	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVO	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	4.1	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVO (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		4.1	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	8FLQ	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	2.55	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLQ (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.55	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLR	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-	Gs/β1/γ2	2.94	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLR (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-		2.94	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLS	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Abaloparatide	-	Gs/β1/γ2	3.09	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLS (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Abaloparatide	-		3.09	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLT	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	M-PTH(1-14)	-	Gs/β1/γ2	3.03	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLT (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	M-PTH(1-14)	-		3.03	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLU	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH	-	Gs/β1/γ2	2.76	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLU (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH	-		2.76	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8HA0	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	chim(NtGi1-Gs)/β1/γ2	2.62	2022-12-21	doi.org/10.1038/s41401-022-01032-z
	8HA0 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.62	2022-12-21	doi.org/10.1038/s41401-022-01032-z
	8HAF	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-	chim(NtGi1-Gs)/β1/γ2	3.25	2022-12-21	doi.org/10.1038/s41401-022-01032-z
	8HAF (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-		3.25	2022-12-21	doi.org/10.1038/s41401-022-01032-z
	8HAO	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	chim(NtGi1-Gs)/β1/γ2	3.76	2022-12-21	doi.org/10.1038/s41401-022-01032-z
	8HAO (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		3.76	2022-12-21	doi.org/10.1038/s41401-022-01032-z
	6FJ3	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	-	2.5	2018-11-21	doi.org/10.1038/s41594-018-0151-4
	6NBF	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-	Gs/β1/γ2	3	2019-04-17	doi.org/10.1126/science.aav7942
	6NBF (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-		3	2019-04-17	doi.org/10.1126/science.aav7942
	6NBH	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-	Gs/β1/γ2	3.5	2019-04-17	doi.org/10.1126/science.aav7942
	6NBH (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-		3.5	2019-04-17	doi.org/10.1126/science.aav7942
	6NBI	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-	Gs/β1/γ2	4	2019-04-17	doi.org/10.1126/science.aav7942
	6NBI (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-		4	2019-04-17	doi.org/10.1126/science.aav7942
	9B5Y	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH	-	chim(NtGi1-Gq)/β1/γ2	3.49	2025-03-19	doi.org/10.1073/pnas.2426178122
	9B5Y (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH	-		3.49	2025-03-19	doi.org/10.1073/pnas.2426178122
	7Y35	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Abaloparatide	-	Gs/β1/γ2	2.9	2023-07-05	To be published
	7Y35 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Abaloparatide	-		2.9	2023-07-05	To be published
	7Y36	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Teriparatide	-	Gs/β1/γ2	2.8	2023-07-05	To be published
	7Y36 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Teriparatide	-		2.8	2023-07-05	To be published
	9JR2	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.8	2024-10-16	To be published
	9JR2 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.8	2024-10-16	To be published
	9JR3	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.8	2024-10-16	To be published
	9JR3 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.8	2024-10-16	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9LRD_nogp.zip

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or use this QR code to link and share this page.

You can also read or download a guide explaining the meaning of all files and numerical data.