psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I37	R:R:V33	3.07	No	No	0	7	4
2	R:R:L34	R:R:W455	11.39	No	Yes	0	8	9
3	R:R:C38	R:R:M81	4.86	No	Yes	0	9	9
4	R:R:L44	R:R:V40	4.47	No	No	0	9	4
5	R:R:G77	R:R:T41	3.64	No	Yes	1	9	9
6	R:R:M81	R:R:T41	9.03	Yes	Yes	1	9	9
7	R:R:T41	R:R:T462	10.99	Yes	No	0	9	9
8	R:R:G43	R:R:V42	3.68	No	No	0	6	6
9	R:R:L46	R:R:V42	2.98	No	No	0	8	6
10	R:R:L44	R:R:P465	3.28	No	No	0	9	9
11	R:R:N45	R:R:S70	2.98	No	No	0	9	9
12	R:R:D73	R:R:N45	6.73	Yes	No	0	9	9
13	R:R:N45	R:R:P465	13.03	No	No	0	9	9
14	R:R:F479	R:R:L47	4.87	Yes	No	0	9	9
15	R:R:S70	R:R:V48	6.46	No	No	0	9	9
16	R:R:P469	R:R:V48	3.53	No	No	0	9	9
17	R:R:L49	R:R:R53	9.72	No	No	0	8	6
18	R:R:S54	R:R:Y50	5.09	No	No	0	7	5
19	R:R:I482	R:R:Y50	10.88	No	No	0	8	5
20	R:R:E55	R:R:S54	4.31	No	No	0	8	7
21	R:R:L58	R:R:N63	5.49	No	No	0	9	9
22	R:R:F475	R:R:L58	7.31	Yes	No	0	9	9
23	R:R:H59	R:R:K141	6.55	No	No	0	8	8
24	R:R:T60	R:R:V61	3.17	No	Yes	0	9	9
25	R:R:N63	R:R:T60	7.31	No	No	0	9	9
26	R:R:G62	R:R:V61	3.68	No	Yes	0	8	9
27	R:R:R139	R:R:V61	5.23	No	Yes	0	9	9
28	R:R:N472	R:R:N63	5.45	No	No	0	9	9
29	R:R:I120	R:R:Y65	4.84	Yes	Yes	5	8	8
30	R:R:L121	R:R:Y65	5.86	No	Yes	0	9	8
31	R:R:D124	R:R:Y65	13.79	No	Yes	0	9	8
32	R:R:T147	R:R:Y65	6.24	No	Yes	5	8	8
33	R:R:I148	R:R:Y65	4.84	No	Yes	0	9	8
34	R:R:I66	R:R:P469	6.77	No	No	0	9	9
35	R:R:S117	R:R:S68	4.89	No	No	0	8	9
36	R:R:I148	R:R:S68	9.29	No	No	0	9	9
37	R:R:S68	R:R:W152	4.94	No	Yes	0	9	9
38	R:R:D73	R:R:L69	5.43	Yes	Yes	3	9	9
39	R:R:L69	R:R:V118	4.47	Yes	No	3	9	9
40	R:R:L69	R:R:N464	10.98	Yes	No	3	9	9
41	R:R:L69	R:R:Y468	3.52	Yes	Yes	3	9	9
42	R:R:I75	R:R:V71	3.07	No	No	0	8	6
43	R:R:A72	R:R:W152	3.89	No	Yes	0	9	9
44	R:R:D73	R:R:S114	5.89	Yes	No	0	9	9
45	R:R:D73	R:R:S461	10.31	Yes	No	0	9	9
46	R:R:D73	R:R:N464	9.42	Yes	No	3	9	9
47	R:R:A110	R:R:I75	3.25	No	No	0	8	8
48	R:R:V76	R:R:V80	3.21	No	No	1	9	9
49	R:R:V76	R:R:Y458	3.79	No	Yes	1	9	9
50	R:R:S461	R:R:V76	8.08	No	No	0	9	9
51	R:R:G77	R:R:M81	6.99	No	Yes	1	9	9
52	R:R:M106	R:R:V79	9.13	No	No	0	8	6
53	R:R:D107	R:R:V80	13.15	Yes	No	1	9	9
54	R:R:V80	R:R:Y458	5.05	No	Yes	1	9	9
55	R:R:M81	R:R:W455	4.65	Yes	Yes	1	9	9
56	R:R:M81	R:R:Y458	3.59	Yes	Yes	1	9	9
57	R:R:M83	R:R:W93	8.14	Yes	Yes	1	8	9
58	R:R:M83	R:R:W103	16.29	Yes	Yes	1	8	9
59	R:R:N84	R:R:W103	11.3	Yes	Yes	1	8	9
60	R:R:I454	R:R:N84	7.08	Yes	Yes	1	8	8
61	R:R:N84	R:R:W455	3.39	Yes	Yes	1	8	9
62	R:R:N84	R:R:Y458	11.63	Yes	Yes	1	8	9
63	R:R:I85	R:R:W455	4.7	No	Yes	0	8	9
64	R:R:W93	R:R:Y87	12.54	Yes	No	1	9	7
65	R:R:W103	R:R:Y87	5.79	Yes	No	1	9	7
66	R:R:C180	R:R:Y87	5.38	Yes	No	1	9	7
67	R:R:L88	R:R:W455	3.42	No	Yes	0	8	9
68	R:R:M90	R:R:S94	6.13	No	No	0	5	5
69	R:R:E177	R:R:K92	6.75	No	No	0	3	2
70	R:R:L95	R:R:W93	12.53	No	Yes	1	9	9
71	R:R:L99	R:R:W93	3.42	No	Yes	1	7	9
72	R:R:C100	R:R:W93	7.84	No	Yes	1	9	9
73	R:R:W103	R:R:W93	8.43	Yes	Yes	1	9	9
74	R:R:C180	R:R:W93	7.84	Yes	Yes	1	9	9
75	R:R:L95	R:R:L99	9.69	No	No	1	9	7
76	R:R:R175	R:R:R97	23.46	No	No	0	4	5
77	R:R:D183	R:R:R97	3.57	No	No	0	7	5
78	R:R:C100	R:R:L104	3.17	No	Yes	1	9	9
79	R:R:C100	R:R:C180	7.28	No	Yes	1	9	9
80	R:R:L101	R:R:L163	5.54	No	No	0	8	7
81	R:R:F102	R:R:M106	9.95	No	No	0	8	8
82	R:R:L104	R:R:W103	5.69	Yes	Yes	1	9	9
83	R:R:C180	R:R:L104	4.76	Yes	Yes	1	9	9
84	R:R:L104	R:R:T182	4.42	Yes	No	0	9	9
85	R:R:S105	R:R:V159	3.23	No	No	0	9	5
86	R:R:D107	R:R:S111	4.42	Yes	No	1	9	9
87	R:R:D107	R:R:Y458	13.79	Yes	Yes	1	9	9
88	L:L:?1	R:R:D107	10.22	Yes	Yes	1	0	9
89	R:R:W158	R:R:Y108	15.43	Yes	Yes	1	8	9
90	R:R:I162	R:R:Y108	3.63	No	Yes	0	9	9
91	R:R:F184	R:R:Y108	6.19	Yes	Yes	1	9	9
92	R:R:Y108	R:R:Y431	2.98	Yes	Yes	1	9	9
93	L:L:?1	R:R:Y108	19.86	Yes	Yes	1	0	9
94	R:R:S111	R:R:W428	4.94	No	Yes	1	9	9
95	L:L:?1	R:R:S111	7.07	Yes	No	1	0	9
96	R:R:F116	R:R:T112	6.49	No	Yes	1	8	9
97	R:R:S155	R:R:T112	3.2	Yes	Yes	1	9	9
98	R:R:T112	R:R:W158	9.7	Yes	Yes	1	9	8
99	R:R:N198	R:R:T112	10.24	Yes	Yes	1	9	9
100	L:L:?1	R:R:T112	5.55	Yes	Yes	1	0	9
101	R:R:A113	R:R:W152	9.08	No	Yes	1	9	9
102	R:R:A113	R:R:S155	3.42	No	Yes	1	9	9
103	R:R:F424	R:R:I115	3.77	Yes	No	0	9	9
104	R:R:I115	R:R:W428	15.27	No	Yes	0	9	9
105	R:R:F116	R:R:N198	7.25	No	Yes	1	8	9
106	R:R:I120	R:R:S117	3.1	Yes	No	0	8	8
107	R:R:M206	R:R:V118	4.56	Yes	No	0	9	9
108	R:R:V118	R:R:Y468	7.57	No	Yes	3	9	9
109	R:R:F119	R:R:P202	4.33	No	No	0	8	9
110	R:R:F119	R:R:L205	4.87	No	No	0	8	6
111	R:R:F119	R:R:M206	3.73	No	Yes	0	8	9
112	R:R:I120	R:R:T147	4.56	Yes	No	5	8	8
113	R:R:A151	R:R:I120	3.25	No	Yes	0	7	8
114	R:R:L121	R:R:R125	6.07	No	No	0	9	9
115	R:R:L121	R:R:Y468	8.21	No	Yes	0	9	9
116	R:R:C122	R:R:M206	6.48	No	Yes	0	8	9
117	R:R:C122	R:R:F209	4.19	No	Yes	0	8	7
118	R:R:C122	R:R:Y210	14.79	No	Yes	0	8	9
119	R:R:F209	R:R:I123	8.79	Yes	No	0	7	6
120	R:R:D124	R:R:S128	4.42	No	No	0	9	9
121	R:R:R125	R:R:Y210	3.09	No	Yes	0	9	9
122	R:R:Q130	R:R:Y126	14.65	No	Yes	6	8	9
123	R:R:F209	R:R:Y126	12.38	Yes	Yes	0	7	9
124	R:R:K212	R:R:Y126	7.17	No	Yes	6	5	9
125	R:R:I213	R:R:Y126	3.63	No	Yes	0	9	9
126	R:R:R127	R:R:R134	17.06	No	No	7	8	5
127	R:R:R127	R:R:Y138	3.09	No	Yes	7	8	8
128	R:R:I213	R:R:V129	4.61	No	No	0	9	9
129	R:R:Q130	R:R:Q131	3.84	No	No	0	8	7
130	R:R:K212	R:R:Q130	6.78	No	No	6	5	8
131	R:R:P132	R:R:Q131	7.9	No	No	0	9	7
132	R:R:R134	R:R:Y138	11.32	No	Yes	7	5	8
133	R:R:R134	R:R:R139	3.2	No	No	0	5	9
134	R:R:L136	R:R:Y135	5.86	No	No	0	8	9
135	R:R:L136	R:R:Y138	14.07	No	Yes	0	8	8
136	R:R:R143	R:R:Y138	12.35	No	Yes	0	9	8
137	R:R:T140	R:R:T142	4.71	No	No	0	9	6
138	R:R:S145	R:R:T142	3.2	No	No	0	6	6
139	R:R:S155	R:R:W152	3.71	Yes	Yes	1	9	9
140	R:R:F153	R:R:F156	3.22	No	No	0	5	5
141	R:R:F184	R:R:W158	4.01	Yes	Yes	1	9	8
142	R:R:T194	R:R:W158	7.28	No	Yes	0	8	8
143	R:R:I160	R:R:P161	3.39	No	No	0	8	9
144	R:R:F190	R:R:P161	4.33	Yes	No	0	9	9
145	R:R:N166	R:R:W165	6.78	No	No	0	6	9
146	R:R:T172	R:R:W165	3.64	No	No	0	4	9
147	R:R:H167	R:R:N166	15.31	No	No	0	4	6
148	R:R:F168	R:R:F184	7.5	Yes	Yes	0	6	9
149	R:R:F168	R:R:V187	10.49	Yes	No	0	6	8
150	R:R:F168	R:R:F190	5.36	Yes	Yes	0	6	9
151	R:R:Q170	R:R:Q171	5.12	No	Yes	0	5	2
152	R:R:Q171	R:R:V174	10.03	Yes	Yes	2	2	2
153	R:R:Q171	R:R:Y185	6.76	Yes	No	2	2	7
154	R:R:D186	R:R:Q171	14.36	No	Yes	2	3	2
155	R:R:R176	R:R:V174	9.15	No	Yes	2	1	2
156	R:R:E181	R:R:V174	8.56	Yes	Yes	2	7	2
157	R:R:E181	R:R:R176	3.49	Yes	No	2	7	1
158	R:R:D178	R:R:E447	3.9	No	No	0	3	4
159	R:R:E447	R:R:K179	8.1	No	No	0	4	4
160	R:R:E181	R:R:Y185	7.86	Yes	No	2	7	7
161	R:R:F184	R:R:T182	5.19	Yes	No	0	9	9
162	R:R:D186	R:R:Y185	13.79	No	No	2	3	7
163	R:R:A439	R:R:T188	3.36	No	No	0	8	8
164	R:R:F190	R:R:T194	7.78	Yes	No	0	9	8
165	R:R:F435	R:R:K191	17.37	No	No	0	8	9
166	R:R:I438	R:R:K191	4.36	No	No	0	6	9
167	R:R:A195	R:R:M436	3.22	No	No	0	9	7
168	R:R:F432	R:R:N198	6.04	Yes	Yes	1	9	9
169	L:L:?1	R:R:N198	7.75	Yes	Yes	1	0	9
170	R:R:F199	R:R:Y200	14.44	Yes	No	0	9	8
171	R:R:F199	R:R:T203	11.67	Yes	No	1	9	9
172	R:R:F199	R:R:F424	4.29	Yes	Yes	1	9	9
173	R:R:F199	R:R:W428	3.01	Yes	Yes	1	9	9
174	R:R:F199	R:R:F432	23.58	Yes	Yes	1	9	9
175	R:R:I433	R:R:Y200	4.84	No	No	0	7	8
176	R:R:M436	R:R:Y200	4.79	No	No	0	7	8
177	R:R:L201	R:R:P202	3.28	No	No	0	7	9
178	R:R:L201	R:R:L205	4.15	No	No	0	7	6
179	R:R:F424	R:R:T203	7.78	Yes	No	1	9	9
180	R:R:F424	R:R:M206	8.71	Yes	Yes	0	9	9
181	R:R:L207	R:R:M421	4.24	No	No	0	7	9
182	R:R:F209	R:R:W208	6.01	Yes	No	0	7	4
183	R:R:L417	R:R:Y210	3.52	No	Yes	0	9	9
184	R:R:R218	R:R:Y214	3.09	No	Yes	0	7	8
185	R:R:A414	R:R:Y214	4	No	Yes	0	9	8
186	R:R:R409	R:R:V217	3.92	Yes	No	0	8	9
187	R:R:H220	R:R:R218	6.77	No	No	8	8	7
188	R:R:E410	R:R:R218	3.49	No	No	8	8	7
189	R:R:Q219	R:R:R409	16.35	No	Yes	0	5	8
190	R:R:E410	R:R:H220	12.31	No	No	8	8	8
191	R:R:L405	R:R:N408	4.12	No	No	0	5	7
192	R:R:L405	R:R:R409	3.64	No	Yes	0	5	8
193	R:R:M407	R:R:N408	4.21	No	No	0	3	7
194	R:R:E410	R:R:R409	11.63	No	Yes	0	8	8
195	R:R:I420	R:R:Q416	5.49	No	No	0	9	9
196	R:R:C471	R:R:Q416	9.16	No	No	0	9	9
197	R:R:G418	R:R:M421	5.24	No	No	0	8	9
198	R:R:F419	R:R:I467	10.05	No	No	0	7	9
199	R:R:I420	R:R:Y468	4.84	No	Yes	0	9	9
200	R:R:I425	R:R:L426	5.71	No	No	0	8	5
201	R:R:I425	R:R:I429	4.42	No	No	0	8	8
202	R:R:C427	R:R:N460	9.45	No	No	0	9	9
203	R:R:F432	R:R:W428	4.01	Yes	Yes	1	9	9
204	R:R:G457	R:R:W428	8.44	No	Yes	0	9	9
205	R:R:N460	R:R:W428	9.04	No	Yes	0	9	9
206	R:R:I429	R:R:P430	3.39	No	No	0	8	9
207	R:R:I429	R:R:I433	2.94	No	No	0	8	7
208	R:R:L456	R:R:P430	3.28	No	No	0	9	9
209	R:R:F432	R:R:Y431	6.19	Yes	Yes	1	9	9
210	R:R:T453	R:R:Y431	4.99	No	Yes	0	9	9
211	R:R:I454	R:R:Y431	4.84	Yes	Yes	1	8	9
212	L:L:?1	R:R:Y431	24.27	Yes	Yes	1	0	9
213	R:R:F432	R:R:F435	8.57	Yes	No	0	9	8
214	L:L:?1	R:R:F432	9.17	Yes	Yes	1	0	9
215	R:R:F434	R:R:I438	3.77	No	No	0	7	6
216	R:R:F434	R:R:L449	8.53	No	No	0	7	4
217	R:R:I438	R:R:N446	7.08	No	No	0	6	6
218	R:R:C441	R:R:N443	4.72	No	No	0	7	4
219	R:R:C441	R:R:C444	7.28	No	No	9	7	5
220	R:R:E447	R:R:N446	10.52	No	No	0	4	6
221	R:R:H450	R:R:I454	6.63	No	Yes	0	7	8
222	R:R:F452	R:R:L456	9.74	No	No	0	5	9
223	R:R:I454	R:R:W455	3.52	Yes	Yes	1	8	9
224	R:R:I454	R:R:Y458	9.67	Yes	Yes	1	8	9
225	R:R:W455	R:R:Y458	3.86	Yes	Yes	1	9	9
226	L:L:?1	R:R:Y458	4.41	Yes	Yes	1	0	9
227	R:R:N460	R:R:N464	12.26	No	No	0	9	9
228	R:R:I467	R:R:Y468	3.63	No	Yes	0	9	9
229	R:R:E473	R:R:N472	9.2	No	No	0	5	9
230	R:R:E473	R:R:F475	4.66	No	Yes	0	5	9
231	R:R:F475	R:R:F479	5.36	Yes	Yes	0	9	9
232	R:R:F479	R:R:T478	5.19	Yes	No	0	9	8
233	R:R:I197	R:R:M193	2.92	No	No	0	5	7
234	R:R:F475	R:R:P469	2.89	Yes	No	0	9	9
235	R:R:I485	R:R:L47	2.85	No	No	0	8	9
236	R:R:I459	R:R:L463	2.85	No	No	0	6	8
237	R:R:L86	R:R:M83	2.83	No	Yes	0	6	8
238	R:R:L88	R:R:M451	2.83	No	No	0	8	6
239	R:R:G96	R:R:W93	2.81	No	Yes	0	8	9
240	R:R:L46	R:R:L74	2.77	No	No	0	8	8
241	R:R:A144	R:R:Y65	2.67	No	Yes	0	9	8
242	R:R:A413	R:R:Y214	2.67	No	Yes	0	9	8
243	R:R:H406	R:R:M407	2.63	No	No	0	5	3
244	R:R:F190	R:R:M193	2.49	Yes	No	0	9	7
245	R:R:F479	R:R:L470	2.44	Yes	No	0	9	8
246	R:R:M421	R:R:Y210	2.39	No	Yes	0	9	9
247	R:R:I75	R:R:W152	2.35	No	Yes	0	8	9
248	R:R:F168	R:R:Q170	2.34	Yes	No	0	6	5
249	R:R:L417	R:R:Y214	2.34	No	Yes	0	9	8
250	R:R:E181	R:R:R97	2.33	Yes	No	0	7	5
251	R:R:G96	R:R:P98	2.03	No	No	0	8	5
252	R:R:G77	R:R:V42	1.84	No	No	0	9	6
253	R:R:C38	R:R:S35	1.72	No	No	0	9	7
254	R:R:G150	R:R:L149	1.71	No	No	0	5	7
255	R:R:C441	R:R:V437	1.71	No	No	9	7	8
256	R:R:C444	R:R:V437	1.71	No	No	9	5	8
257	R:R:A78	R:R:V79	1.7	No	No	0	7	6
258	R:R:A216	R:R:V129	1.7	No	No	0	6	9
259	R:R:G164	R:R:N166	1.7	No	No	0	7	6
260	R:R:M28	R:R:P29	1.68	No	No	0	5	3
261	R:R:A51	R:R:T478	1.68	No	No	0	9	8
262	R:R:M81	R:R:P82	1.68	Yes	No	0	9	9
263	R:R:M83	R:R:P82	1.68	Yes	No	0	8	9
264	R:R:L133	R:R:P132	1.64	No	No	0	8	9
265	R:R:S35	R:R:V31	1.62	No	No	0	7	7
266	R:R:A51	R:R:I482	1.62	No	No	0	9	8
267	R:R:S105	R:R:V109	1.62	No	No	0	9	9
268	R:R:S155	R:R:V109	1.62	Yes	No	0	9	9
269	R:R:S173	R:R:V174	1.62	No	Yes	0	3	2
270	R:R:A423	R:R:I467	1.62	No	No	0	8	9
271	R:R:A439	R:R:K191	1.61	No	No	0	8	9
272	R:R:V67	R:R:V71	1.6	No	No	4	8	6
273	R:R:C38	R:R:L39	1.59	No	No	0	9	7
274	R:R:T188	R:R:V192	1.59	No	No	0	8	8
275	R:R:C427	R:R:L463	1.59	No	No	0	9	8
276	R:R:A144	R:R:L64	1.58	No	No	0	9	8
277	R:R:A78	R:R:L74	1.58	No	No	0	7	8
278	R:R:C444	R:R:N446	1.57	No	No	0	5	6
279	R:R:I196	R:R:V192	1.54	No	No	0	7	8
280	R:R:K92	R:R:S91	1.53	No	No	0	2	3
281	R:R:I37	R:R:T41	1.52	No	Yes	0	7	9
282	R:R:K141	R:R:V61	1.52	No	Yes	0	8	9
283	R:R:F153	R:R:G150	1.51	No	No	0	5	5
284	R:R:L64	R:R:S145	1.5	No	No	0	8	6
285	R:R:L95	R:R:S94	1.5	No	No	0	9	5
286	R:R:L89	R:R:V31	1.49	No	No	0	6	7
287	R:R:L49	R:R:V67	1.49	No	No	4	8	8
288	R:R:L49	R:R:V71	1.49	No	No	4	8	6
289	R:R:L163	R:R:V159	1.49	No	No	0	7	5
290	R:R:A439	R:R:F440	1.39	No	No	0	8	7
291	R:R:L30	R:R:L34	1.38	No	No	0	9	8
292	R:R:L30	R:R:L88	1.38	No	No	0	9	8
293	R:R:L47	R:R:L483	1.38	No	No	0	9	8
294	R:R:D186	R:R:K442	1.38	No	No	0	3	3
295	R:R:F156	R:R:V109	1.31	No	No	0	5	9
296	R:R:I482	R:R:R481	1.25	No	No	0	8	6
297	R:R:F153	R:R:L157	1.22	No	No	0	5	5
298	R:R:D183	R:R:W165	1.12	No	No	0	7	9
299	R:R:F190	R:R:W189	1	Yes	No	0	9	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:T41	6.295	4	1	9
2	R:R:V61	3.4	4	0	9
3	R:R:Y65	6.37333	6	5	8
4	R:R:L69	6.1	4	3	9
5	R:R:D73	7.556	5	3	9
6	R:R:M81	5.13333	6	1	9
7	R:R:M83	7.235	4	1	8
8	R:R:N84	8.35	4	1	8
9	R:R:W93	7.94375	8	1	9
10	R:R:W103	9.5	5	1	9
11	R:R:L104	4.51	4	1	9
12	R:R:D107	10.395	4	1	9
13	R:R:Y108	9.618	5	1	9
14	R:R:T112	7.036	5	1	9
15	R:R:I120	3.9375	4	5	8
16	R:R:Y126	9.4575	4	6	9
17	R:R:Y138	10.2075	4	7	8
18	R:R:W152	4.794	5	1	9
19	R:R:S155	2.9875	4	1	9
20	R:R:W158	9.105	4	1	8
21	R:R:F168	6.4225	4	0	6
22	R:R:Q171	9.0675	4	2	2
23	R:R:V174	7.34	4	2	2
24	R:R:C180	6.315	4	1	9
25	R:R:E181	5.56	4	2	7
26	R:R:F184	5.7225	4	1	9
27	R:R:F190	4.192	5	0	9
28	R:R:N198	7.82	4	1	9
29	R:R:F199	11.398	5	1	9
30	R:R:M206	5.87	4	0	9
31	R:R:F209	7.8425	4	0	7
32	R:R:Y210	5.9475	4	0	9
33	R:R:Y214	3.025	4	0	8
34	R:R:R409	8.885	4	0	8
35	R:R:F424	6.1375	4	1	9
36	R:R:W428	7.45167	6	1	9
37	R:R:Y431	8.654	5	1	9
38	R:R:F432	9.59333	6	1	9
39	R:R:I454	6.348	5	1	8
40	R:R:W455	4.99	7	1	9
41	R:R:Y458	6.97375	8	1	9
42	R:R:Y468	5.554	5	3	9
43	R:R:F475	5.055	4	0	9
44	R:R:F479	4.465	4	0	9
45	L:L:?1	11.0375	8	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:C38	R:R:M81	11.3952	4.86	No	Yes	0	9	9
2	R:R:M81	R:R:Y458	42.0571	3.59	Yes	Yes	1	9	9
3	R:R:V76	R:R:Y458	51.7205	3.79	No	Yes	1	9	9
4	R:R:S461	R:R:V76	52.5602	8.08	No	No	0	9	9
5	R:R:D73	R:R:S461	52.3203	10.31	Yes	No	0	9	9
6	R:R:D73	R:R:N45	75.1631	6.73	Yes	No	0	9	9
7	R:R:G77	R:R:V42	18.3447	1.84	No	No	0	9	6
8	R:R:L46	R:R:V42	13.8466	2.98	No	No	0	8	6
9	R:R:N45	R:R:S70	67.9061	2.98	No	No	0	9	9
10	R:R:F475	R:R:F479	26.9436	5.36	Yes	Yes	0	9	9
11	R:R:F475	R:R:P469	60.5218	2.89	Yes	No	0	9	9
12	R:R:P469	R:R:V48	64.1128	3.53	No	No	0	9	9
13	R:R:S70	R:R:V48	66.0169	6.46	No	No	0	9	9
14	L:L:?1	R:R:Y458	84.594	4.41	Yes	Yes	1	0	9
15	L:L:?1	R:R:T112	45.9705	5.55	Yes	Yes	1	0	9
16	R:R:S155	R:R:T112	56.1511	3.2	Yes	Yes	1	9	9
17	R:R:S155	R:R:W152	35.8348	3.71	Yes	Yes	1	9	9
18	R:R:I75	R:R:W152	15.9157	2.35	No	Yes	0	8	9
19	R:R:I75	R:R:V71	10.593	3.07	No	No	0	8	6
20	R:R:F479	R:R:T478	15.9982	5.19	Yes	No	0	9	8
21	R:R:A51	R:R:T478	13.7567	1.68	No	No	0	9	8
22	R:R:A51	R:R:I482	11.5001	1.62	No	No	0	9	8
23	R:R:F475	R:R:L58	30.0247	7.31	Yes	No	0	9	9
24	R:R:L58	R:R:N63	28.1655	5.49	No	No	0	9	9
25	R:R:T60	R:R:V61	24.0123	3.17	No	Yes	0	9	9
26	R:R:N63	R:R:T60	26.1789	7.31	No	No	0	9	9
27	R:R:R139	R:R:V61	15.181	5.23	No	Yes	0	9	9
28	R:R:S68	R:R:W152	27.3559	4.94	No	Yes	0	9	9
29	R:R:D73	R:R:L69	37.739	5.43	Yes	Yes	3	9	9
30	R:R:L69	R:R:Y468	37.3041	3.52	Yes	Yes	3	9	9
31	R:R:L121	R:R:Y468	27.2059	8.21	No	Yes	0	9	9
32	R:R:L121	R:R:Y65	25.7516	5.86	No	Yes	0	9	8
33	R:R:I148	R:R:S68	21.5758	9.29	No	No	0	9	9
34	R:R:I148	R:R:Y65	21.0585	4.84	No	Yes	0	9	8
35	R:R:L69	R:R:V118	14.6863	4.47	Yes	No	3	9	9
36	R:R:D73	R:R:N464	13.3518	9.42	Yes	No	3	9	9
37	R:R:L46	R:R:L74	11.5751	2.77	No	No	0	8	8
38	R:R:N84	R:R:W103	35.7448	11.3	Yes	Yes	1	8	9
39	R:R:N84	R:R:Y458	25.6241	11.63	Yes	Yes	1	8	9
40	L:L:?1	R:R:Y108	68.3559	19.86	Yes	Yes	1	0	9
41	R:R:F184	R:R:Y108	84.6765	6.19	Yes	Yes	1	9	9
42	R:R:F168	R:R:F184	93.5003	7.5	Yes	Yes	0	6	9
43	R:R:F168	R:R:Q170	74.6833	2.34	Yes	No	0	6	5
44	R:R:Q170	R:R:Q171	71.9844	5.12	No	Yes	0	5	2
45	R:R:Q171	R:R:V174	34.6953	10.03	Yes	Yes	2	2	2
46	R:R:E181	R:R:V174	26.0814	8.56	Yes	Yes	2	7	2
47	R:R:E181	R:R:R97	46.4653	2.33	Yes	No	0	7	5
48	R:R:Q171	R:R:Y185	28.8402	6.76	Yes	No	2	2	7
49	R:R:E181	R:R:Y185	26.1564	7.86	Yes	No	2	7	7
50	R:R:D183	R:R:R97	35.205	3.57	No	No	0	7	5
51	R:R:L104	R:R:W103	10.3606	5.69	Yes	Yes	1	9	9
52	R:R:S155	R:R:V109	24.5821	1.62	Yes	No	0	9	9
53	R:R:S105	R:R:V109	10.0082	1.62	No	No	0	9	9
54	R:R:L104	R:R:T182	14.3489	4.42	Yes	No	0	9	9
55	R:R:F184	R:R:T182	16.0357	5.19	Yes	No	0	9	9
56	L:L:?1	R:R:S111	11.9124	7.07	Yes	No	1	0	9
57	R:R:W158	R:R:Y108	17.9774	15.43	Yes	Yes	1	8	9
58	R:R:T112	R:R:W158	29.7399	9.7	Yes	Yes	1	9	8
59	R:R:I454	R:R:Y431	20.7962	4.84	Yes	Yes	1	8	9
60	R:R:S111	R:R:W428	16.0657	4.94	No	Yes	1	9	9
61	L:L:?1	R:R:F432	80.7482	9.17	Yes	Yes	1	0	9
62	R:R:F432	R:R:W428	31.2017	4.01	Yes	Yes	1	9	9
63	R:R:F199	R:R:F424	83.7094	4.29	Yes	Yes	1	9	9
64	R:R:F199	R:R:F432	100	23.58	Yes	Yes	1	9	9
65	R:R:F424	R:R:M206	86.0559	8.71	Yes	Yes	0	9	9
66	R:R:F119	R:R:M206	15.0611	3.73	No	Yes	0	8	9
67	R:R:L121	R:R:R125	15.391	6.07	No	No	0	9	9
68	R:R:C122	R:R:M206	73.9636	6.48	No	Yes	0	8	9
69	R:R:C122	R:R:F209	34.178	4.19	No	Yes	0	8	7
70	R:R:C122	R:R:Y210	45.3632	14.79	No	Yes	0	8	9
71	R:R:F209	R:R:Y126	25.834	12.38	Yes	Yes	0	7	9
72	R:R:Q130	R:R:Y126	11.5976	14.65	No	Yes	6	8	9
73	R:R:R134	R:R:R139	13.2169	3.2	No	No	0	5	9
74	R:R:A144	R:R:Y65	13.4868	2.67	No	Yes	0	9	8
75	R:R:A144	R:R:L64	10.8179	1.58	No	No	0	9	8
76	R:R:F153	R:R:F156	10.0082	3.22	No	No	0	5	5
77	R:R:F156	R:R:V109	12.4747	1.31	No	No	0	5	9
78	R:R:T194	R:R:W158	32.3562	7.28	No	Yes	0	8	8
79	R:R:F190	R:R:P161	14.3414	4.33	Yes	No	0	9	9
80	R:R:F168	R:R:F190	16.3955	5.36	Yes	Yes	0	6	9
81	R:R:F190	R:R:T194	28.0756	7.78	Yes	No	0	9	8
82	R:R:D183	R:R:W165	29.38	1.12	No	No	0	7	9
83	R:R:N166	R:R:W165	17.67	6.78	No	No	0	6	9
84	R:R:I438	R:R:N446	25.0618	7.08	No	No	0	6	6
85	R:R:I438	R:R:K191	33.9006	4.36	No	No	0	6	9
86	R:R:F435	R:R:K191	51.8105	17.37	No	No	0	8	9
87	R:R:F432	R:R:F435	54.7417	8.57	Yes	No	0	9	8
88	R:R:A439	R:R:K191	15.7733	1.61	No	No	0	8	9
89	R:R:F199	R:R:Y200	28.4729	14.44	Yes	No	0	9	8
90	R:R:I433	R:R:Y200	20.1289	4.84	No	No	0	7	8
91	R:R:L417	R:R:Y210	42.327	3.52	No	Yes	0	9	9
92	R:R:L417	R:R:Y214	39.3058	2.34	No	Yes	0	9	8
93	R:R:R218	R:R:Y214	30.8944	3.09	No	Yes	0	7	8
94	R:R:E410	R:R:R218	24.687	3.49	No	No	8	8	7
95	R:R:E410	R:R:R409	22.0031	11.63	No	Yes	0	8	8
96	R:R:L405	R:R:R409	12.6771	3.64	No	Yes	0	5	8
97	R:R:I420	R:R:Y468	12.3173	4.84	No	Yes	0	9	9
98	R:R:I467	R:R:Y468	12.6471	3.63	No	Yes	0	9	9
99	R:R:I429	R:R:I433	17.3551	2.94	No	No	0	8	7
100	R:R:C427	R:R:N460	14.6113	9.45	No	No	0	9	9
101	R:R:N460	R:R:W428	42.6944	9.04	No	Yes	0	9	9
102	R:R:C444	R:R:N446	12.6471	1.57	No	No	0	5	6
103	R:R:F190	R:R:M193	14.9411	2.49	Yes	No	0	9	7
104	R:R:W455	R:R:Y458	12.2798	3.86	Yes	Yes	1	9	9
105	R:R:G77	R:R:M81	20.3014	6.99	No	Yes	1	9	9
106	R:R:W103	R:R:W93	20.7287	8.43	Yes	Yes	1	9	9
107	R:R:Y108	R:R:Y431	37.7839	2.98	Yes	Yes	1	9	9
108	R:R:F432	R:R:Y431	51.0533	6.19	Yes	Yes	1	9	9
109	R:R:N460	R:R:N464	30.5495	12.26	No	No	0	9	9
110	R:R:F432	R:R:N198	18.9744	6.04	Yes	Yes	1	9	9
111	R:R:M206	R:R:V118	27.9481	4.56	Yes	No	0	9	9
112	R:R:R125	R:R:Y210	15.226	3.09	No	Yes	0	9	9
113	R:R:V118	R:R:Y468	12.7071	7.57	No	Yes	3	9	9
114	R:R:L69	R:R:N464	16.4855	10.98	Yes	No	3	9	9
115	R:R:N198	R:R:T112	17.4901	10.24	Yes	Yes	1	9	9
116	R:R:F184	R:R:W158	10.3531	4.01	Yes	Yes	1	9	8
117	R:R:I454	R:R:N84	11.1103	7.08	Yes	Yes	1	8	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:V76	R:R:V80	3.21	1	No	No	9	9	2	2
R:R:V76	R:R:Y458	3.79	1	No	Yes	9	9	2	1
R:R:D107	R:R:V80	13.15	1	Yes	No	9	9	1	2
R:R:V80	R:R:Y458	5.05	1	No	Yes	9	9	2	1
R:R:M81	R:R:W455	4.65	1	Yes	Yes	9	9	2	2
R:R:M81	R:R:Y458	3.59	1	Yes	Yes	9	9	2	1
R:R:I454	R:R:N84	7.08	1	Yes	Yes	8	8	2	2
R:R:N84	R:R:W455	3.39	1	Yes	Yes	8	9	2	2
R:R:N84	R:R:Y458	11.63	1	Yes	Yes	8	9	2	1
R:R:D107	R:R:S111	4.42	1	Yes	No	9	9	1	1
R:R:D107	R:R:Y458	13.79	1	Yes	Yes	9	9	1	1
L:L:?1	R:R:D107	10.22	1	Yes	Yes	0	9	0	1
R:R:W158	R:R:Y108	15.43	1	Yes	Yes	8	9	2	1
R:R:I162	R:R:Y108	3.63	0	No	Yes	9	9	2	1
R:R:F184	R:R:Y108	6.19	1	Yes	Yes	9	9	2	1
R:R:Y108	R:R:Y431	2.98	1	Yes	Yes	9	9	1	1
L:L:?1	R:R:Y108	19.86	1	Yes	Yes	0	9	0	1
R:R:S111	R:R:W428	4.94	1	No	Yes	9	9	1	2
L:L:?1	R:R:S111	7.07	1	Yes	No	0	9	0	1
R:R:F116	R:R:T112	6.49	1	No	Yes	8	9	2	1
R:R:S155	R:R:T112	3.2	1	Yes	Yes	9	9	2	1
R:R:T112	R:R:W158	9.7	1	Yes	Yes	9	8	1	2
R:R:N198	R:R:T112	10.24	1	Yes	Yes	9	9	1	1
L:L:?1	R:R:T112	5.55	1	Yes	Yes	0	9	0	1
R:R:F116	R:R:N198	7.25	1	No	Yes	8	9	2	1
R:R:F184	R:R:W158	4.01	1	Yes	Yes	9	8	2	2
R:R:F432	R:R:N198	6.04	1	Yes	Yes	9	9	1	1
L:L:?1	R:R:N198	7.75	1	Yes	Yes	0	9	0	1
R:R:F199	R:R:W428	3.01	1	Yes	Yes	9	9	2	2
R:R:F199	R:R:F432	23.58	1	Yes	Yes	9	9	2	1
R:R:F432	R:R:W428	4.01	1	Yes	Yes	9	9	1	2
R:R:F432	R:R:Y431	6.19	1	Yes	Yes	9	9	1	1
R:R:T453	R:R:Y431	4.99	0	No	Yes	9	9	2	1
R:R:I454	R:R:Y431	4.84	1	Yes	Yes	8	9	2	1
L:L:?1	R:R:Y431	24.27	1	Yes	Yes	0	9	0	1
R:R:F432	R:R:F435	8.57	1	Yes	No	9	8	1	2
L:L:?1	R:R:F432	9.17	1	Yes	Yes	0	9	0	1
R:R:I454	R:R:W455	3.52	1	Yes	Yes	8	9	2	2
R:R:I454	R:R:Y458	9.67	1	Yes	Yes	8	9	2	1
R:R:W455	R:R:Y458	3.86	1	Yes	Yes	9	9	2	1
L:L:?1	R:R:Y458	4.41	1	Yes	Yes	0	9	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7DFL_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.94
Number of Linked Nodes	251
Number of Links	299
Number of Hubs	45
Number of Links mediated by Hubs	164
Number of Communities	9
Number of Nodes involved in Communities	65
Number of Links involved in Communities	95

Path Summary
Number Of Nodes in MetaPath	118
Number Of Links MetaPath	117
Number of Shortest Paths	51809
Length Of Smallest Path	3
Average Path Length	12.4035
Length of Longest Path	31
Minimum Path Strength	1.365
Average Path Strength	6.68642
Maximum Path Strength	19.01
Minimum Path Correlation	0.7
Average Path Correlation	0.922368
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.16667
Average % Of Corr. Nodes	54.638
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	51.451
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• regulation of tube diameter • multicellular organismal process • regulation of biological process • system process • regulation of tube size • regulation of system process • biological regulation • positive regulation of biological process • positive regulation of vasoconstriction • circulatory system process • regulation of blood circulation • vascular process in circulatory system • regulation of vasoconstriction • positive regulation of multicellular organismal process • regulation of multicellular organismal process • blood vessel diameter maintenance • regulation of biological quality • vasoconstriction • blood circulation • regulation of anatomical structure size • cellular response to stimulus • regulation of cellular process • response to stimulus • signaling • phospholipase C-activating G protein-coupled receptor signaling pathway • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • trans-synaptic signaling • synaptic signaling • anterograde trans-synaptic signaling • cell-cell signaling • chemical synaptic transmission • regulation of synaptic plasticity • regulation of signaling • modulation of chemical synaptic transmission • regulation of trans-synaptic signaling • regulation of cell communication • cellular response to nitrogen compound • cellular response to chemical stimulus • response to histamine • response to chemical • cellular response to histamine • response to nitrogen compound • defense response • response to stress • inflammatory response • regulation of vascular permeability • behavior • learning or memory • nervous system process • cognition • memory • response to light stimulus • learning • visual learning • visual behavior • associative learning • response to radiation • response to abiotic stimulus • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • cellular anatomical structure • synapse • cell junction • intracellular anatomical structure • cytoplasm • cytosol • cell periphery • plasma membrane • membrane • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection
Gene Ontology	Cellular Component	• cellular anatomical structure • synapse • cell junction • intracellular anatomical structure • cytoplasm • cytosol • cell periphery • plasma membrane • membrane • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • organelle membrane • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • G-protein beta-subunit binding • fibroblast proliferation • GTPase regulator activity • enzyme regulator activity • enzyme activator activity • GTPase activator activity • molecular function activator activity • nucleoside-triphosphatase regulator activity • molecular function regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • G-protein beta/gamma-subunit complex binding • G protein activity • signaling receptor binding • G protein-coupled receptor binding • cation binding • metal ion binding • D2 dopamine receptor binding • dopamine receptor binding • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • enzyme inhibitor activity • adenylate cyclase regulator activity • magnesium ion binding • GDP binding • G protein-coupled serotonin receptor binding • regulation of signaling • cell surface receptor signaling pathway • regulation of Wnt signaling pathway • regulation of canonical Wnt signaling pathway • canonical Wnt signaling pathway • regulation of signal transduction • regulation of response to stimulus • regulation of cell communication • Wnt signaling pathway • neuropeptide signaling pathway • regulation of body fluid levels • wound healing • hemostasis • blood coagulation • response to stress • coagulation • regulation of biological quality • response to wounding • regulation of protein stability • protein stabilization • phospholipase C-activating serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • rhythmic process • entrainment of circadian clock • circadian rhythm • response to external stimulus • regulation of circadian rhythm • glutamate receptor signaling pathway • detection of light stimulus • response to light stimulus • phototransduction • detection of external stimulus • detection of visible light • detection of abiotic stimulus • detection of stimulus • response to abiotic stimulus • response to radiation • phototransduction, visible light • cell activation • regulation of cell activation • regulation of platelet activation • regulation of multicellular organismal process • platelet activation • phospholipase C-activating G protein-coupled glutamate receptor signaling pathway • G protein-coupled glutamate receptor signaling pathway • adenylate cyclase-inhibiting serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • response to peptide hormone • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • nuclear membrane • nucleus • endomembrane system • organelle envelope • nuclear envelope • Golgi apparatus • cytosolic region • postsynapse • postsynaptic cytosol • midbody • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • nucleoplasm • ciliary basal body
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	HSM
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	HSM
Name	Histamine
Synonyms	1H-Imidazole-4-ethanamine
Identifier
Formula	C5 H9 N3
Molecular Weight	111.145
SMILES
PubChem	774
Formal Charge	0
Total Atoms	17
Total Chiral Atoms	0
Total Bonds	17
Total Aromatic Bonds	5


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P35367
Sequence	>7DFL_nogp_Chain_R M P L V V V L S T I C L V T V G L N L L V L Y A V R S E R K L H T V G N L Y I V S L S V A D L I V G A V V M P M N I L Y L L M S K W S L G R P L C L F W L S M D Y V A S T A S I F S V F I L C I D R Y R S V Q Q P L R Y L K Y R T K T R A S A T I L G A W F L S F L W V I P I L G W N H F M Q Q T S V R R E D K C E T D F Y D V T W F K V M T A I I N F Y L P T L L M L W F Y A K I Y K A V R Q H C L H M N R E R K A A K Q L G F I M A A F I L C W I P Y F I F F M V I A F C K N C C N E H L H M F T I W L G Y I N S T L N P L I Y P L C N E N F K K T F K R I L H I Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8GH1	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	4.1	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	2RH1	A	Amine	Adrenergic	β₂	Homo sapiens	S-Carazolol	-	-	2.4	2007-10-30	doi.org/10.1126/science.1150577
	3RZE	A	Amine	Histamine	H₁	Homo sapiens	Cidoxepin	-	-	3.1	2011-06-15	doi.org/10.1038/nature10236
	7DFL	A	Amine	Histamine	H₁	Homo sapiens	Histamine	-	chim(NtGi1L-Gq)/β1/γ2	3.3	2021-03-31	doi.org/10.1038/s41467-021-22427-2
	7DFL (No Gprot)	A	Amine	Histamine	H₁	Homo sapiens	Histamine	-		3.3	2021-03-31	doi.org/10.1038/s41467-021-22427-2
	8X5X	A	Amine	Histamine	H₁	Homo sapiens	-	-	-	3.5	2024-01-17	doi.org/10.1038/s41467-023-44477-4
	8X5Y	A	Amine	Histamine	H₁	Homo sapiens	Astemizole	-	-	3	2024-01-17	doi.org/10.1038/s41467-023-44477-4
	8X63	A	Amine	Histamine	H₁	Homo sapiens	Mepyramine	-	-	3.2	2024-01-17	doi.org/10.1038/s41467-023-44477-4
	8X64	A	Amine	Histamine	H₁	Homo sapiens	Desloratadine	-	-	3.4	2024-01-17	doi.org/10.1038/s41467-023-44477-4
	8YN2	A	Amine	Histamine	H₁	Homo sapiens	Histamine	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.66	2024-10-09	doi.org/10.1038/s41467-024-52585-y
	8YN2 (No Gprot)	A	Amine	Histamine	H₁	Homo sapiens	Histamine	-		2.66	2024-10-09	doi.org/10.1038/s41467-024-52585-y
	9LRD	A	Amine	Histamine	H₁	Homo sapiens	Histamine	-	Gi1/β1/γ2	3.23	2025-06-11	To be published
	9LRD (No Gprot)	A	Amine	Histamine	H₁	Homo sapiens	Histamine	-		3.23	2025-06-11	To be published
	9LRB	A	Amine	Histamine	H₁	Homo sapiens	Histamine	-	Gs/β1/γ2	2.77	2025-06-11	To be published
	9LRB (No Gprot)	A	Amine	Histamine	H₁	Homo sapiens	Histamine	-		2.77	2025-06-11	To be published
	8WSS	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	Pro-MCH	-	Gi1/β1/γ1	3.01	2024-06-19	doi.org/10.1038/s41421-024-00679-8
	8WSS (No Gprot)	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	Pro-MCH	-		3.01	2024-06-19	doi.org/10.1038/s41421-024-00679-8
	8YNS	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	SNAP-94847	-	-	3.33	2024-12-18	doi.org/10.1038/s41421-024-00754-0
	8YNT	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	SNAP-94847	-	-	3.43	2024-12-18	doi.org/10.1038/s41421-024-00754-0
	8WWK	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	MCH	-	Gi1/β1/γ2	2.61	2024-11-13	doi.org/10.1038/s41421-024-00754-0
	8WWK (No Gprot)	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	MCH	-		2.61	2024-11-13	doi.org/10.1038/s41421-024-00754-0
	8WWL	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	MCH	-	Gi1/β1/γ2	2.78	2024-11-13	doi.org/10.1038/s41421-024-00754-0
	8WWL (No Gprot)	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	MCH	-		2.78	2024-11-13	doi.org/10.1038/s41421-024-00754-0
	8WWM	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	MCH	-	Gi1/β1/γ2	2.81	2024-11-13	doi.org/10.1038/s41421-024-00754-0
	8WWM (No Gprot)	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	MCH	-		2.81	2024-11-13	doi.org/10.1038/s41421-024-00754-0
	8WWN	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	MCH	-	Gi1/β1/γ2	2.65	2024-11-13	doi.org/10.1038/s41421-024-00754-0
	8WWN (No Gprot)	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	MCH	-		2.65	2024-11-13	doi.org/10.1038/s41421-024-00754-0
	8WWH	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	-	-	Gi1/β1/γ2	2.84	2024-11-13	To be published
	8WWH (No Gprot)	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	-	-		2.84	2024-11-13	To be published
	8WWI	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	-	-	Gi1/β1/γ2	3.43	2024-11-13	To be published
	8WWI (No Gprot)	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	-	-		3.43	2024-11-13	To be published
	8WWJ	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	-	-	Gi1/β1/γ2	3.03	2024-11-13	To be published
	8WWJ (No Gprot)	A	Peptide	Melanin Concentrating Hormone	MCH1	Homo sapiens	-	-		3.03	2024-11-13	To be published
	8GW8	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	-	PCO371	Gs/β1/γ2	2.9	2023-06-14	doi.org/10.1038/s41586-023-06169-3
	8GW8 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	-	PCO371		2.9	2023-06-14	doi.org/10.1038/s41586-023-06169-3
	8JR9	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	-	PCO371	chim(NtGi1-Gs)/β1/γ2	2.57	2023-08-02	doi.org/10.1038/s41586-023-06467-w
	8JR9 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	-	PCO371		2.57	2023-08-02	doi.org/10.1038/s41586-023-06467-w
	7VVJ	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-	Gs/β1/γ2	3.2	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVJ (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-		3.2	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVK	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	3.3	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVK (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		3.3	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVL	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	2.8	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVL (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.8	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVM	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	3.2	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVM (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		3.2	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVN	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	3.8	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVN (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		3.8	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVO	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	4.1	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVO (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		4.1	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	8FLQ	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	2.55	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLQ (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.55	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLR	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-	Gs/β1/γ2	2.94	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLR (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-		2.94	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLS	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Abaloparatide	-	Gs/β1/γ2	3.09	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLS (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Abaloparatide	-		3.09	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLT	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	M-PTH(1-14)	-	Gs/β1/γ2	3.03	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLT (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	M-PTH(1-14)	-		3.03	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLU	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH	-	Gs/β1/γ2	2.76	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLU (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH	-		2.76	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8HA0	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	chim(NtGi1-Gs)/β1/γ2	2.62	2022-12-21	doi.org/10.1038/s41401-022-01032-z
	8HA0 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.62	2022-12-21	doi.org/10.1038/s41401-022-01032-z
	8HAF	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-	chim(NtGi1-Gs)/β1/γ2	3.25	2022-12-21	doi.org/10.1038/s41401-022-01032-z
	8HAF (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-		3.25	2022-12-21	doi.org/10.1038/s41401-022-01032-z
	8HAO	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	chim(NtGi1-Gs)/β1/γ2	3.76	2022-12-21	doi.org/10.1038/s41401-022-01032-z
	8HAO (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		3.76	2022-12-21	doi.org/10.1038/s41401-022-01032-z
	6FJ3	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	-	2.5	2018-11-21	doi.org/10.1038/s41594-018-0151-4
	6NBF	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-	Gs/β1/γ2	3	2019-04-17	doi.org/10.1126/science.aav7942
	6NBF (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-		3	2019-04-17	doi.org/10.1126/science.aav7942
	6NBH	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-	Gs/β1/γ2	3.5	2019-04-17	doi.org/10.1126/science.aav7942
	6NBH (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-		3.5	2019-04-17	doi.org/10.1126/science.aav7942
	6NBI	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-	Gs/β1/γ2	4	2019-04-17	doi.org/10.1126/science.aav7942
	6NBI (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-		4	2019-04-17	doi.org/10.1126/science.aav7942
	9B5Y	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH	-	chim(NtGi1-Gq)/β1/γ2	3.49	2025-03-19	doi.org/10.1073/pnas.2426178122
	9B5Y (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH	-		3.49	2025-03-19	doi.org/10.1073/pnas.2426178122
	7Y35	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Abaloparatide	-	Gs/β1/γ2	2.9	2023-07-05	To be published
	7Y35 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Abaloparatide	-		2.9	2023-07-05	To be published
	7Y36	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Teriparatide	-	Gs/β1/γ2	2.8	2023-07-05	To be published
	7Y36 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Teriparatide	-		2.8	2023-07-05	To be published
	9JR2	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.8	2024-10-16	To be published
	9JR2 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.8	2024-10-16	To be published
	9JR3	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.8	2024-10-16	To be published
	9JR3 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.8	2024-10-16	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7DFL_nogp.zip

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You can also read or download a guide explaining the meaning of all files and numerical data.