| 5ht1_off | 5ht1b_off |
| 5ht1_on | 5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on |
| 5ht1a_on | 8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2 |
| 5ht1b_off | 5V54-5-HT1B-Methiothepin |
| 5ht1b_on | 6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2 |
| 5ht1d_on | 7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2 |
| 5ht1e_on | 7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2 |
| 5ht1f_on | 7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2 |
| 5ht2_off | 5ht2a_off 5ht2b_off 5ht2c_off |
| 5ht2_on | 5ht2a_on 5ht2c_on |
| 5ht2a_off | 6A94-5-HT2A-Zotepine 6WH4-5-HT2A-Methiothepin 7VOE-5-HT2A-Aripiprazole 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 6A93-5-HT2A-Risperidone |
| 5ht2a_on | 7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 |
| 5ht2b_off | 6DRZ-5-HT2B-Methysergide 6DRX-5-HT2B-Lisuride |
| 5ht2c_off | 6BQH-5-HT2C-Ritanserin |
| 5ht2c_on | 8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 |
| 5ht4_on | 7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2 |
| 5ht5_off | 5ht5a_off |
| 5ht5_on | 5ht5a_on |
| 5ht5a_off | 7UM4-5-HT5A-AS2674723 |
| 5ht5a_on | 7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2 |
| 5ht6_on | 7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2 |
| 5ht7_on | 7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2 |
| 5ht_off | 5ht2_off 5ht5_off 5ht1_off |
| 5ht_on | 5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on |
| a1_off | 5UEN-A1-DU172 5N2S-A1-PSB36 |
| a1_on | 7LD4-A1-Adenosine-Gi2/&β;1/&γ;2 |
| a1_on_allo | 7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2 |
| a2_off | a2a_off |
| a2_on | a2a_on a2b_on |
| a2a_off | 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 5UIG-A2A-J3.651.884G 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-PubChem 168451710 5K2D-A2A-ZM241385 |
| a2a_off_allo | 6ZDR-A2A-HMS1413f12-Na 6GT3-A2A-Imaradenant-Na 8CU7-A2A-LJ-4517-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PubChem 92460631; psb36-Na 5MZJ-A2A-Theophylline-Na 5OLO-A2A-Tozadenant-Na 5OLH-A2A-Vipadenant-Na 5NM4-A2A-ZM241385-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5MZP-A2A-Caffeine-Na 8CIC-A2A-Etrumadenant-Na |
| a2a_on | 6GDG-A2A-NECA-Gs/&β;1/&γ;1 |
| a2b_on | 8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2 |
| adenosine_off | a1_off a2_off |
| adenosine_on | a1_on a2_on |
| adgrf1_on_allo | 7WU5-ADGRF1-K6G-Gi1/&β;1/&γ;2 8G2Y-ADGRF1-LPC-chim(Gs-CtGq)/&β;1/&γ;2 |
| adgrg2_on | 7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2 |
| adgrg3_on | 7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2 |
| adgrg_on | adgrg2_on adgrg3_on |
| adrenergic_off | beta_off alpha_off |
| adrenergic_on | beta_on alpha_on |
| alpha1_off | alpha1a_off alpha1b_off |
| alpha1_on | alpha1a_on |
| alpha1a_off | 7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1 |
| alpha1a_on | 7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 |
| alpha1b_off | 7B6W-α1b-Cyclazosin |
| alpha2_off | alpha2a_off alpha2c_off |
| alpha2_on | alpha2a_on alpha2b_on |
| alpha2a_off | 6KUX-α2a-RS-79948 |
| alpha2a_on | 7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2 |
| alpha2b_on | 6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2 |
| alpha2c_off | 6KUW-α2c-PubChem 57213234 |
| alpha_off | alpha1_off alpha2_off |
| alpha_on | alpha1_on alpha2_on |
| amine_off | adrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off |
| amine_on | adrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on |
| angiotensin_off | at1_off at2_off |
| angiotensin_on | at1_on |
| apelin_on | 7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2 |
| arrestin1 | 5W0P-Rhodopsin-Arrestin1 |
| arrestin2 | 6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-AVP-Arrestin2 |
| at1_off | 4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan |
| at1_on | 7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2 |
| at2_off | 7JNI-AT2-Olodanrigan |
| bb1_on | 8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 |
| bb2_off | 7W41-BB2-PD176252 |
| bb2_on | 7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2 |
| beta1_off | 2VT4-β1-Cyanopindolol 2YCZ-β1-Iodocyanopindolol |
| beta1_off_allo | 4BVN-β1-Cyanopindolol-Na |
| beta1_on | 7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2 |
| beta2_off | 6PS2-β2-(S)-Alprenolol 6PS3-β2-(S)-Carvedilol 6PS5-β2-(S)-Propranolol 6PS6-β2-Timolol 2RH1-β2-(S)-Carazolol 6PS4-β2-ICI 118-551 3NY9-β2-PubChem 913103 |
| beta2_off_allo | 6OBA-β2-(S)-Alprenolol-GTPL11074 |
| beta2_on | 3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2 |
| beta3_on | 7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2 |
| beta_off | beta1_off beta2_off |
| beta_on | beta1_on beta2_on beta3_on |
| bileacid_on | 7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2 |
| bk1_on | 7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 |
| bk2_on | 7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2 |
| blt1_off | 7K15-BLT1-MKD046-Na |
| blt1_on | 7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2 |
| blt_off | blt1_off |
| blt_on | blt1_on |
| bombesin_off | bb2_off |
| bombesin_on | bb2_on bb1_on |
| bradykinin_on | bk2_on bk1_on |
| c3a_on | 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2 8I95-C3aB-EP54-Go/&β;1/&γ;2 |
| c5a1_off_ortoallo | 6C1Q-C5a1-PMX53-NDT9513727 6C1R-C5a1-PMX53-Avacopan; Na |
| c5a1_on | 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 |
| calcitonin_on | ct_on ctlike_on |
| cannabinoid_off | cb1_off cb2_off |
| cannabinoid_on | cb1_on cb2_on |
| cb1_off | 5TGZ-CB1-AM6538 5U09-CB1-Taranabant |
| cb1_off_allo | 6KQI-CB1-PubMed 104895-ORG27569 |
| cb1_on | 8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2 |
| cb1_on_allo | 7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2 |
| cb2_off | 5ZTY-CB2-AM10257 |
| cb2_on | 8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2 |
| cck_off | ccka_off |
| cck_on | ccka_on cckb_on |
| ccka_off | 7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript |
| ccka_on | 7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2 |
| cckb_on | 7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 |
| ccr1_on | 7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 |
| ccr2_off_allo | 5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812 |
| ccr2_on | 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 |
| ccr5_off | 5UIW-CCR5-5P7-CCL5 |
| ccr5_on | 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 |
| ccr6_on | 6WWZ-CCR6-CCL20-Go/&β;1/&γ;2 |
| ccr7_off_allo | 6QZH-CCR7-HY-133073; Na |
| ccr8_off | 8TLM-CCR8-Anti-murine CCR8 antibody |
| ccr8_on | 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2 |
| ccr9_off_allo | 5LWE-CCR9-Vercirnon |
| ccr_off | ccr5_off ccr8_off |
| ccr_on | ccr5_on ccr6_on ccr1_on ccr2_on ccr8_on |
| chemerin_on | cml1_on |
| chemokine_off | cxcr_off |
| chemokine_on | cxcr_on cx3cr_on |
| class-a_off | sensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off |
| class-a_on | sensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on |
| class-b1_on | glucagon_on calcitonin_on vip-pacap_on pth_on crf_on |
| class-b2_on | adgrg_on |
| class-c_off | gabab_off mglu_off |
| class-c_on | gabab_on mglu_on |
| class-d_off | ste2_off |
| class-d_on | ste2_on |
| class-f_off | smo_off |
| class-t_on | taste2_on |
| cml1_on | 8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2 |
| compl-peptide_on | c5a1_on c3a_on |
| crf1_on | 6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2 |
| crf2_on | 7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2 |
| crf_on | crf2_on crf1_on |
| ct_on | 7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 |
| ctlike_on | 6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2 |
| cx3cr1_on | 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 |
| cx3cr_on | cx3cr1_on |
| cxcr1_on | 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 |
| cxcr2_on | 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 |
| cxcr4_off | 4RWS-CXCR4-vMIP-II |
| cxcr_off | cxcr4_off |
| cxcr_on | cxcr1_on cxcr2_on |
| cyslt1_off_ortoallo | 6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na |
| cyslt2_off | 6RZ6-CysLT2-ONO-2570366 6RZ9-CysLT2-ONO-2770372 6RZ8-CysLT2-ONO-2080365 |
| cyslt_off | cyslt2_off |
| d1_on | 7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRR-D1-Rotigotine-Gs/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2 |
| d1_on_allo | 7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2 |
| d2_off | 6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone |
| d2_on | 7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2 |
| d3_off | 3PBL-D3-Eticlopride |
| d3_on | 8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2 |
| d4_off | 5WIU-D4-Nemonapride |
| d4_off_allo | 5WIV-D4-Nemonapride-Na |
| d5_on | 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 |
| dop_off | 4EJ4-δ-Naltrindole |
| dop_off_allo | 4N6H-δ-Naltrindole-Na |
| dop_on | 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 |
| dopamine_off | d3_off d2_off d4_off |
| dopamine_on | d3_on d2_on d5_on d1_on |
| dp2_off | 6D27-DP2-CAY10471 6D26-DP2-Fevipiprant |
| dp_off | dp2_off |
| endothelin_off | etb_off |
| endothelin_on | etb_on eta_on |
| ep2_on | 7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2 |
| ep3_on | 8GDC-EP3-PGE2-Gi1/&β;1/&γ;2 |
| ep4_off | 5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352 |
| ep4_on | 7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2 |
| ep_off | ep4_off |
| ep_on | ep4_on ep2_on ep3_on |
| eta_on | 8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 |
| etb_off | 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500 5X93-ETB-K-8794 |
| etb_on | 8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2 |
| ffa1_on | 8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 |
| ffa2_on | 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 |
| ffa3_on | 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2 |
| ffa3_on_allo | 8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2 |
| ffa4_on | 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2 |
| ffa4_on_allo | 8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 |
| ffa_on | ffa4_on ffa1_on ffa2_on ffa3_on |
| fpa_on | 8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 |
| fpr-alx_on | fpr1-alx_on fpr2-alx_on |
| fpr1-alx_on | 7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 |
| fpr2-alx_on | 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2 |
| fsh_on_allo | 8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2 |
| gabab_off | 7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970 |
| gabab_on | 7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2 |
| gal1_on | 7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2 |
| gal2_on | 7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 |
| galanin_on | gal2_on gal1_on |
| ghrelin_off | 6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457 |
| ghrelin_on | 7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2 |
| ghrh_on | 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 |
| gi_5ht | 7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2 |
| gi_adrenergic | 7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2 |
| gi_amine | gi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine |
| gi_apelin | 7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2 |
| gi_cannabinoid | 8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2 |
| gi_cck | 7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2 |
| gi_chemerin | 8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2 |
| gi_chemokine | 7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2 |
| gi_class-a | gi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar |
| gi_class-c | gi_mglu gi_gaba |
| gi_class-d | gi_ste |
| gi_class-f | gi_frizzled |
| gi_compl-peptide | 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 |
| gi_dopamine | 8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2 |
| gi_endothelin | 8IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2 |
| gi_ffa | 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2 |
| gi_formylpeptide | 7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2 |
| gi_frizzled | 6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2 |
| gi_gaba | 7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2 |
| gi_galanin | 7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2 |
| gi_ghrelin | 7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2 |
| gi_hca | 8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2 |
| gi_hcar | gi_hca |
| gi_histamine | 8HN8-H4-Histamine-Gi1/&β;1/&γ;2 8HOC-H4-Imetit-Gi1/&β;1/&γ;2 |
| gi_leukotriene | 7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2 |
| gi_lipid | gi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene |
| gi_lpl | 7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2 |
| gi_melatonin | 7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1 |
| gi_mglu | 7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2 |
| gi_muscarinic | 7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2 |
| gi_neuromedin | 7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2 |
| gi_neuropeptide | 7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2 |
| gi_neurotensin | 7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2 |
| gi_nucleotide | 7LD4-A1-Adenosine-Gi2/&β;1/&γ;2 |
| gi_opioid | 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2 |
| gi_peptide | gi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck |
| gi_prostanoid | 8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GDC-EP3-PGE2-Gi1/&β;1/&γ;2 8GCM-EP4-L902688-Gi1/&β;1/&γ;2 |
| gi_protein | gi_chemokine gi_chemerin |
| gi_relaxin | 7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2 |
| gi_somatostatin | 7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2 |
| gi_ste | 7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2 |
| gip_on | 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 |
| gip_on_allo | 7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2 |
| glp1_on | 6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 |
| glp1_on_allo | 6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2 |
| glp2_on | 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 |
| glp_on | glp1_on glp2_on |
| glu_on | 6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2 |
| glucagon_on | gip_on glu_on secretin_on ghrh_on glp_on |
| gnrh1_off | 7BR3-GnRH1-Elagolix |
| gnrh_off | gnrh1_off |
| go_5ht | 6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2 |
| go_adhesion | 7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2 |
| go_adrenergic | 7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2 |
| go_amine | go_adrenergic go_muscarinic go_5ht |
| go_chemokine | 6WWZ-CCR6-CCL20-Go/&β;1/&γ;2 |
| go_class-a | go_amine go_peptide go_protein |
| go_class-b | go_class-b1 go_class-b2 |
| go_class-b1 | go_crf |
| go_class-b2 | go_adhesion |
| go_compl-peptide | 8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2 |
| go_crf | 7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2 |
| go_galanin | 7XJJ-GAL1-Galanin-Go/&β;1/&γ;2 |
| go_ghrelin | 7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 |
| go_muscarinic | 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2 |
| go_opioid | 8DZQ-κ-momSalB-Go/&β;1/&γ;2 |
| go_peptide | go_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin |
| go_protein | go_chemokine |
| go_vasopressin | 7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2 |
| gphr_on | lh_on tsh_on |
| gpr119_on | 7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2 |
| gq_amine | gq_muscarinic gq_histamine |
| gq_angiotensin | 7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2 |
| gq_bombesin | 7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2 |
| gq_bradykinin | 7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2 |
| gq_cck | 8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2 |
| gq_class-a | gq_amine gq_peptide |
| gq_histamine | 7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2 |
| gq_muscarinic | 6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2 |
| gq_peptide | gq_cck gq_angiotensin gq_bombesin gq_bradykinin |
| gs_5ht | 7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2 7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2 7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 |
| gs_adenosine | 8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A2A-NECA-Gs/&β;1/&γ;1 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2 |
| gs_adgr | 7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2 |
| gs_adrenergic | 3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJI-β3-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2 |
| gs_amine | gs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar |
| gs_bileacid | 7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2 |
| gs_bombesin | 8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 |
| gs_bradykinin | 7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 |
| gs_calcitonin | gs_ct gs_cgrp |
| gs_cck | 7MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2 |
| gs_cgrp | 6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2 |
| gs_class-a | gs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid |
| gs_class-b | gs_class-b1 gs_class-b2 |
| gs_class-b1 | gs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf |
| gs_class-b2 | gs_adgr |
| gs_class-t | gs_taste |
| gs_compl-peptide | 8I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 |
| gs_crf | 6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2 |
| gs_ct | 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3 |
| gs_dopamine | 7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2 |
| gs_endothelin | 8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 |
| gs_ffa | 8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2 8GDB-EP4-PGE2-Gs/&β;1/&γ;2 |
| gs_galanin | 7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 |
| gs_ghrelin | 7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 |
| gs_glucagon | 6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 |
| gs_gphr | 7T9I-TSH-TSH-Gs/&β;1/&γ;2 7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2 |
| gs_histamine | 7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 |
| gs_lipid | gs_ffa gs_prostanoid |
| gs_melanocortin | 7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 |
| gs_motilin | 8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 |
| gs_muscarinic | 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 |
| gs_neuromedin | 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 |
| gs_nucleotide | gs_adenosine |
| gs_orexin | 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 |
| gs_peptide | gs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin |
| gs_prostanoid | 8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 |
| gs_protein | gs_gphr |
| gs_pth | 8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 |
| gs_sst | 7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 |
| gs_steroid | gs_bileacid |
| gs_tachykinin | 8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 |
| gs_tar | 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2 |
| gs_taste | 7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2 |
| gs_trh | 7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 |
| gs_vasopressin-ot | 7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-AVP-chim(NtGi1-Gs)/&β;1/&γ;2 |
| gs_vip-pacap | 8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2 |
| gt_class-a | gt_opsin |
| gt_opsin | gt_sensory |
| gt_sensory | 6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1 |
| h1_off | 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole 8X63-H1-Mepyramine 8X64-H1-Desloratadine |
| h1_on | 7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2 |
| h3_on_allo | 7F61-H3-PF-03654746-Cholesterol |
| h4_on | 7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 |
| hca2_on | 8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2 |
| hca2_on_allo | 8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2 |
| hca3_on | 8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2 |
| hca_on | hca2_on hca3_on |
| hcar_off | succinate_off |
| hcar_on | hca_on |
| histamine_off | h1_off |
| histamine_on | h1_on h4_on |
| kop_off | 4DJH-κ-JDTic |
| kop_on | 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 |
| leuko_off | blt_off cyslt_off |
| leuko_on | blt_on |
| lh_on | 7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2 |
| lh_on_allo | 7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2 |
| lipid_off | cannabinoid_off leuko_off lpl_off paf_off prostanoid_off |
| lipid_on | cannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on |
| lpa1_off | 4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556 |
| lpa1_on | 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 |
| lpa_off | lpa1_off |
| lpa_on | lpa1_on |
| lpl_off | s1p_off lpa_off |
| lpl_on | s1p_on lpa_on |
| m1_off | 5CXV-M1-Tiotropium |
| m1_off_allo | 6WJC-M1-Atropine-Muscarinic toxin 7 |
| m1_on | 6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2 |
| m2_off | 5ZKB-M2-AF-DX 384 5ZKC-M2-N-Methyl Scopolamine 5ZK3-M2-Quinuclidinyl benzilate hydrobromide |
| m2_on | 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2 |
| m2_on_allo | 7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2 |
| m3_off | 4U15-M3-Tiotropium 4U16-M3-N-Methyl Scopolamine 5ZHP-M3-PubChem 134828589 |
| m3_on | 8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 |
| m4_off | 5DSG-M4-Tiotropium |
| m4_on | 7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2 |
| m4_on_allo | 7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2 |
| m5_off | 6OL9-M5-Tiotropium |
| mc1_on | 7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 |
| mc2_on | 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1 |
| mc3_on | 8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 |
| mc4_on | 7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2 |
| mc5_on | 8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 |
| melanocortin_on | mc2_on mc1_on mc3_on mc4_on mc5_on |
| melatonin_on | mt1_on mt2_on |
| mglu2_off | 7MTQ-mGlu2; mGlu2-LY341495 |
| mglu2_on | 7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2 |
| mglu3_off | 7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193 |
| mglu4_on | 7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2 |
| mglu5_off | 7FD9-mGlu5; mGlu5-LY341495 |
| mglu_off | mglu2_off mglu3_off mglu5_off |
| mglu_on | mglu2_on mglu4_on |
| mop_off | 7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E |
| mop_on | 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2 |
| motilin_on | 8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 |
| mt1_on | 7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2 |
| mt2_on | 7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1 |
| muscarinic_off | m2_off m3_off m4_off m5_off m1_off |
| muscarinic_on | m2_on m3_on m4_on m1_on |
| nk1_off | 6J20-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735 |
| nk1_on | 8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 |
| nk2_on | 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 |
| nmur1_on | 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 |
| nmur2_on | 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 |
| nmur_on | nmur1_on nmur2_on |
| nop_off | 4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111 |
| nop_on | 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 |
| npy1_off | 5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299 |
| npy1_on | 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2 |
| npy2_off | 7DDZ-Y2-JNJ-31020028 |
| npy2_on | 7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 |
| npy4_on | 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 |
| npy_off | npy2_off npy1_off |
| npy_on | npy2_on npy4_on npy1_on |
| nts1_off | 6Z4Q-NTS1-SR142948A 6Z4S-NTS1-SR48692 |
| nts1_off_allo | 7UL2-NTS1-SR48692-Na |
| nts1_on | 6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2 |
| nts1_on_allo | 8JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2 |
| nts_off | nts1_off |
| nts_on | nts1_on |
| nucleotide_off | adenosine_off p2y_off |
| nucleotide_on | adenosine_on |
| opioid_off | kop_off mop_off nop_off dop_off |
| opioid_on | kop_on mop_on nop_on dop_on |
| opsin_off | 1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal |
| opsin_on | 6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1 |
| orexin_off | ox2_off ox1_off |
| orexin_on | ox2_on |
| ot_off | 6TPK-OT-Retosiban |
| ot_on | 7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2 |
| ox1_off | 6TOT-OX1-Lemborexant 6TP4-OX1-ACT-462206 6TP6-OX1-Filorexant 6V9S-OX1-GTPL11403 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ7-OX1-SB-334867 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant |
| ox1_off_allo | 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na 6TO7-OX1-Suvorexant-Na |
| ox2_off | 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant |
| ox2_on | 7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 |
| p2y12_off | 4NTJ-P2Y12-AZD1283 7PP1-P2Y12-Selatogrel |
| p2y1_off | 4XNW-P2Y1-MRS2500 |
| p2y_off | p2y1_off p2y12_off |
| paf_off | 5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417) |
| pca1_on | 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 |
| peptide_off | opioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off |
| peptide_on | opioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on |
| prostanoid_off | ep_off tp_off dp_off |
| prostanoid_on | ep_on fpa_on |
| protein_off | ccr_off chemokine_off gnrh_off |
| protein_on | ccr_on chemokine_on gphr_on chemerin_on |
| pth1_on | 8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 |
| pth2_on | 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 |
| pth_on | pth1_on pth2_on |
| relaxin_on | rxfp4_on |
| rxfp4_on | 7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2 |
| s1p1_off | 3V2Y-S1P1-PubChem 51892645 |
| s1p1_on | 7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2 |
| s1p2_on | 7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2 |
| s1p3_on | 7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 |
| s1p5_on | 7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2 |
| s1p_off | s1p1_off |
| s1p_on | s1p3_on s1p5_on s1p1_on s1p2_on |
| secretin_on | 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 |
| sensory_off | opsin_off |
| sensory_on | opsin_on |
| smo_off | 5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680) |
| smo_off_allo | 6D32-SMO-Cyclopamine-Cyclopamine |
| smo_on_allo | 6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2 |
| sst2_off | 7XNA-SST2-CYN154806 |
| sst2_on | 7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2 |
| sst4_on | 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 |
| sst_off | sst2_off |
| sst_on | sst2_on sst4_on |
| ste2_off | 7QA8-STE2-Peptide |
| ste2_on | 7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2 |
| steroid_on | bileacid_on |
| succinate_off | 6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554 |
| ta1_on | 8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 |
| tachykinin_off | nk1_off |
| tachykinin_on | nk1_on nk2_on |
| tar_on | ta1_on |
| taste2_on | 7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2 |
| tp_off | 6IIV-TP-Daltroban 6IIU-TP-Ramatroban |
| trh_on | 7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 |
| tsh_on | 7T9I-TSH-TSH-Gs/&β;1/&γ;2 |
| tsh_on_allo | 7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2 |
| v2_on | 7DW9-V2-AVP-chim(NtGi1-Gs)/&β;1/&γ;2 |
| vasopressin-ot_off | ot_off |
| vasopressin-ot_on | ot_on v2_on |
| vip-pacap_on | vpac1_on vpac2_on pca1_on |
| vpac1_on | 8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2 |
| vpac2_on | 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 |