Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
11x38 2.10875408
21x47 2.61312409
31x57 4.528509
4I1x50 3.75625408
52x54 3.96409
63x28 3.8075408
73x33 7.945419
83x35 4.75125407
93x38 5.11438409
103x42 7.36937407
113x49 4.85409
12I2 4.33958628
134x42 6.9075628
144x59 0.940625408
15E2 8.921252416
16E2x51 7.0475519
17E2x52 7.24063418
185x40 5.905419
195x44 3.77688406
205x46 4.42812407
215x47 3.88333619
225x58 3.12687407
235x65 2.75625439
24I3 4.0175537
256x47 3.405406
266x48 6.0615519
276x53 3.48188409
28E3 2.82562408
297x41 5.35812419
307x47 3.58687407
317x52 3.9615509
32Lig 7.083591610
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1E2 Lig 63.544917.26YesYes160
23x33 E2 88.11429.1675YesYes196
33x33 3x37 94.79798.0375YesNo099
43x37 5x46 95.794.9825NoYes097
53x41 5x46 94.33534.9925NoYes097
63x41 4x53 94.56336.48NoNo099
73x38 4x53 98.94754.375YesNo099
83x38 4x50 99.90617.3625YesNo099
93x42 4x50 10013.6075YesNo079
102x45 3x42 97.43256.3025NoYes087
112x45 4x42 97.3525.2125NoYes088
123x49 4x42 96.40016.805YesYes098
132x42 3x49 95.58893.9775NoYes099
142x42 3x46 95.59564.44NoNo099
152x43 3x46 94.43594.6175NoNo099
162x43 7x52 93.68515.0275NoYes099
177x52 7x56 44.90854.235YesNo099
187x56 7x57 42.31419.0125NoNo098
192x40 7x57 38.54666.6425NoNo098
202x40 I1x50 35.11434.025NoYes098
211x57 I1x50 16.57173.92YesYes098
221x60 I1x50 13.50144.9575NoYes098
232x60 E2 16.89354.2675NoYes196
242x60 3x28 15.96845.2675NoYes098
254x42 I2 21.23754.31YesYes288
266x48 Lig 20.24544.7775YesYes190
276x48 7x45 17.75836.025YesNo099
286x53 7x45 14.30586.215YesNo099
295x47 Lig 11.73163.9575YesYes190
301x37 1x41 11.31592.825NoNo056
311x41 1x42 12.99192.2975NoNo069
321x42 7x42 14.65442.295NoNo097
331x45 7x42 16.30352.425NoNo097
341x45 7x47 17.93933.35NoYes097
357x47 7x51 29.01393.6525YesNo077
367x51 7x52 32.05743.8525NoYes079
377x41 Lig 20.5946.5275YesYes190
382x54 7x41 20.12475.1075YesYes099
391x46 2x54 15.02315.215NoYes099
401x46 7x46 13.36733.23NoNo098
411x50 7x46 11.69812.1375NoNo098
421x50 2x51 10.01543.86NoNo099
433x34 3x38 11.53056.575NoYes069
443x56 I2 13.76953.9425NoYes258
453x51 3x56 11.81873.93NoNo095
466x47 7x52 44.00355.3575YesYes069
476x47 7x40 41.07395.1875YesNo069
486x42 7x40 38.7412.1425NoNo079
496x41 6x42 36.41481.945NoNo097
505x58 6x41 34.94674.25YesNo079
515x58 6x38 18.38841.73YesNo077
526x34 6x38 15.15051.8075NoNo067
535x58 5x62 12.38182.1325YesNo075
545x62 6x37 10.67242.14NoNo057
555x65 6x34 13.46794.225YesNo096
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
1x39Lig5.1550NoYes9010
3x26E28.59751NoYes5621
3x30E27.530NoYes9621
3x33E29.16751YesYes9621
4x60E210.660NoYes8621
4x61E24.08250NoYes8621
4x64E24.9851NoYes6621
E2E249.45751YesYes6611
E2E2x525.62751YesYes6812
E2Lig17.261YesYes6010
E2E2x515.711YesYes6911
E2x51E2x528.3551YesYes9812
7x37E35.6051NoYes9812
7x41Lig6.52751YesYes9010
2x573x325.081NoNo9812
2x57Lig11.6051NoYes9010
2x60E24.26751NoYes9621
E1E27.540NoYes3621
3x32E2x516.35750NoYes8921
3x33E2x529.441YesYes9822
3x363x405.481NoNo9912
3x36Lig3.9651NoYes9010
3x405x479.91250NoYes9921
3x406x485.51250NoYes9921
3x436x485.2350NoYes7921
5x39E24.43251NoYes9621
5x40E2x514.81751YesYes9911
E2x51Lig9.99751YesYes9010
5x40E2x525.541YesYes9812
5x38E24.15250NoYes9621
5x37Lig5.42251NoYes9010
5x405x434.11251YesNo9912
5x40Lig9.151YesYes9010
5x47Lig3.95751YesYes9010
6x487x418.75751YesYes9911
6x487x456.0251YesNo9912
6x48Lig4.77751YesYes9010
6x55Lig4.1550NoYes9010
7x37Lig6.33251NoYes9010
2x547x415.10750YesYes9921
2x572x613.9351NoNo9912
2x67E23.58250NoYes9621
4x57E23.470NoYes9621
1x31E23.411NoYes0621
3x29E23.28750NoYes9621
5x476x493.01251YesNo9912
5x475x512.771YesNo9212
2x533x362.76750NoNo9921
1x35E22.480NoYes7621
6x587x372.41250NoNo9921
5x476x572.14251YesNo9912
7x38Lig2.00751NoYes8010
5x35E21.9850NoYes7621
6x51Lig1.610NoYes9010
5x476x541.5051YesNo9912
2x64E21.39750NoYes9621
2x73E21.1650NoYes8621
6x567x411.040NoYes9921
6x597x380.8050NoNo9821
5x335x370.58250NoNo6921
5x34E20.4050NoYes5621

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg3_on
76.47Consensusgs_adgrOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
76.47Consensusgs_class-b2Orthosteric Ligandgs_adgr
61.90Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
47.37Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
47.37Consensusgi_class-fOther Ligandgi_frizzled
47.37Consensusgi_frizzledOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
44.44Single6GDGNECA6GDG-A2A-NECA-Gs/&β;1/&γ;1
44.44Consensusa2a_onOrthosteric Ligand6GDG-A2A-NECA-Gs/&β;1/&γ;1
43.75Consensusmglu_onOther Ligandmglu2_on mglu4_on
43.33Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
42.86Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
42.11Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
41.18Single2YDOAdenosine2YDO-A2A-Adenosine
41.18Single6MH8ZM2413856MH8-A2A-ZM241385
41.18Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
40.00Single4N4WSANT-14N4W-SMO-SANT-1
40.00Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
39.13Single3QAKUK-4320973QAK-A2A-UK-432097
38.89Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
38.89Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
38.89Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
38.89Consensusadenosine_onOrthosteric Liganda1_on a2_on
38.89Consensusnucleotide_onOrthosteric Ligandadenosine_on
38.10Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
38.10Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
37.50Single5WF5UK-4320975WF5-A2A-UK-432097
37.50Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
37.50Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
37.50Consensusgo_adhesionOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
37.50Consensusgo_class-b2Orthosteric Ligandgo_adhesion
36.84Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
36.84Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
36.84Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
36.84Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
36.84Consensusa1_on_alloOrthosteric Ligand7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
36.36Single5WF6UK-4320975WF6-A2A-UK-432097
36.36Single5ZTYAM102575ZTY-CB2-AM10257
36.36Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
36.36Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
35.29Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/&β;1/&γ;2
35.29Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
35.29Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/&β;1/&γ;2
35.29Consensusa2a_off_alloOrthosteric Ligand6ZDR-A2A-HMS1413f12-Na 6GT3-A2A-Imaradenant-Na 8CU7-A2A-LJ-4517-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PubChem 92460631; psb36-Na 5MZJ-A2A-Theophylline-Na 5OLO-A2A-Tozadenant-Na 5OLH-A2A-Vipadenant-Na 5NM4-A2A-ZM241385-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5MZP-A2A-Caffeine-Na 8CIC-A2A-Etrumadenant-Na
35.00Single2YDVNECA2YDV-A2A-NECA
35.00Single3UONQuinuclidinyl benzilate hydrobromide3UON-M2-Quinuclidinyl benzilate hydrobromide
35.00Single4UHRCGS216804UHR-A2A-CGS21680
35.00Single5G53NECA5G53-A2A-NECA-Gs
35.00Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
35.00Single7EPENAM5637EPE-mGlu-NAM563
35.00Single7EW7PubChem 40774607EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
35.00Single7PX4PSB-21137PX4-A2A-PSB-2113
35.00Single8G056-OAU8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
35.00Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
35.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
35.00Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
35.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
35.00Consensusa2_onOrthosteric Liganda2a_on a2b_on
35.00Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
35.00Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A2A-NECA-Gs/&β;1/&γ;1 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
35.00Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
33.33Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
33.33Single5IU7Q274563465IU7-A2A-Q27456346-Na
33.33Single5JTBZM2413855JTB-A2A-ZM241385
33.33Single5TE3Octyl Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
33.33Single6AQFZM2413856AQF-A2A-ZM241385
33.33Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
33.33Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
33.33Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
33.33Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
33.33Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2
33.33Single8JWYPubChem 1684517108JWY-A2A-PubChem 168451710
33.33Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6WH4-5-HT2A-Methiothepin 7VOE-5-HT2A-Aripiprazole 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 6A93-5-HT2A-Risperidone
33.33Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
33.33Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
33.33Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
33.33Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
33.33Consensusopioid_offOrthosteric Ligandkop_off mop_off nop_off dop_off
32.00Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
31.82Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
31.82Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
31.82Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
31.82Single7EZCUKA7EZC-A2A-UKA
31.82Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
31.82Single8E9YPubChem 4466038E9Y-M3-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
31.82Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
31.82Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
31.82Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
31.58Single3EMLZM2413853EML-A2A-ZM241385
31.58Single4EIYZM2413854EIY-A2A-ZM241385-Na
31.58Single4EJ4Naltrindole4EJ4-δ-Naltrindole
31.58Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
31.58Single4QIMPubChem 249053754QIM-SMO-PubChem 24905375
31.58Single4X1HNonyl Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
31.58Single5IU8Q274563475IU8-A2A-Q27456347-Na
31.58Single5K2AZM2413855K2A-A2A-ZM241385-Na
31.58Single5OLGZM2413855OLG-A2A-ZM241385-Na
31.58Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
31.58Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
31.58Single5TGZAM65385TGZ-CB1-AM6538
31.58Single5VRAZM2413855VRA-A2A-ZM241385-Na
31.58Single6S0LZM2413856S0L-A2A-ZM241385
31.58Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
31.58Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
31.58Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
31.58Single7PYRPSB-21157PYR-A2A-PSB-2115
31.58Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
31.58Single8CU6LJ-45178CU6-A2A-LJ-4517
31.58Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
31.58Single8J18(3R)-3-hydroxydodecanoic acid8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
31.58Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
31.58Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
31.58Consensusa2_offOrthosteric Liganda2a_off
31.58Consensusa2a_offOrthosteric Ligand8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 5UIG-A2A-J3.651.884G 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-PubChem 168451710 5K2D-A2A-ZM241385
31.58Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
31.58Consensusfsh_on_alloOther Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
30.43Single3NY9PubChem 9131033NY9-β2-PubChem 913103
30.43Single4UG2CGS216804UG2-A2A-CGS21680
30.43Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.43Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
30.00Single5IUAQ274563485IUA-A2A-Q27456348-Na
30.00Single5N2RPubChem 92460631; psb365N2R-A2A-PubChem 92460631; psb36-Na
30.00Single5N2SPSB365N2S-A1-PSB36
30.00Single5NM2ZM2413855NM2-A2A-ZM241385-Na
30.00Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
30.00Single5X7D(S)-Carazolol5X7D-β2-(S)-Carazolol-PubChem 129318963
30.00Single5ZK3Quinuclidinyl benzilate hydrobromide5ZK3-M2-Quinuclidinyl benzilate hydrobromide
30.00Single6LPLZM2413856LPL-A2A-ZM241385-Na
30.00Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
30.00Single6S0QZM2413856S0Q-A2A-ZM241385
30.00Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
30.00Single6WQAZM2413856WQA-A2A-ZM241385-Na
30.00Single7CFNINT-7777CFN-GPBA-INT-777-Gs/&β;1/&γ;2
30.00Single7RM5ZM2413857RM5-A2A-ZM241385-Na
30.00Single7SINNPS-21437SIN-CaS-NPS-2143
30.00Single7SINNPS-21437SIN-CaS-NPS-2143
30.00Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
30.00Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
30.00Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
30.00Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
30.00Single8EA0Iperoxo8EA0-M3-Iperoxo
30.00Single8FYNZM2413858FYN-A2A-ZM241385-Na
30.00Single8GDCPGE28GDC-EP3-PGE2-Gi1/&β;1/&γ;2
30.00Single8GNEKW-63568GNE-A2A-KW-6356-Na
30.00Single8J19PubChem 1270454228J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
30.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
30.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.00Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
30.00Consensusep3_onOrthosteric Ligand8GDC-EP3-PGE2-Gi1/&β;1/&γ;2
30.00Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
30.00Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
29.63Single7KH0Acyclovir triphosphate7KH0-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
29.41Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
29.41Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
29.41Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.41Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
29.17Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
29.17Consensusmop_offOrthosteric Ligand7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
28.57Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
28.57Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
28.57Single5V56TC1145V56-SMO-TC114
28.57Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
28.57Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
28.57Single6J21Aprepitant6J21-NK1-Aprepitant
28.57Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
28.57Single7TUYGSK682753A7TUY-GPR183-GSK682753A
28.57Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2
28.57Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
28.57Single8JD0J9R8JD0-mGlu2; mGlu3-Glutamate-J9R
28.57Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
28.57Single8JXVClozapine8JXV-H4-Clozapine-Gi1/&β;1/&γ;2
28.57Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/&β;1/&γ;2
28.57Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
28.57Consensus5ht1b_onOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
28.57Consensusadenosine_offOrthosteric Liganda1_off a2_off
28.57Consensusgi_amineOrthosteric Ligandgi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
28.57Consensusgi_muscarinicOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
28.00Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
28.00Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
28.00Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
27.78Single3PWHZM2413853PWH-A2A-ZM241385
27.78Single3VGAZM2413853VGA-A2A-ZM241385-Antibody
27.78Single5K2DZM2413855K2D-A2A-ZM241385
27.78Single5U09Taranabant5U09-CB1-Taranabant
27.78Single5ZKQABT-4915ZKQ-PAF-ABT-491
27.78Single6AKXA4R6AKX-CCR5-A4R
27.78Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
27.78Single6JZHZM2413856JZH-A2A-ZM241385-Na
27.78Single6NWEOctyl Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
27.78Single6PS7ZM2413856PS7-A2A-ZM241385-Na
27.78Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2
27.78Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
27.78Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
27.78Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
27.78Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
27.78Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
27.78Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
27.78Single8GNGIstradefylline8GNG-A2A-Istradefylline
27.78Single8HOCImetit8HOC-H4-Imetit-Gi1/&β;1/&γ;2
27.78Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
27.78Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
27.78Consensusgi_histamineOrthosteric Ligand8HN8-H4-Histamine-Gi1/&β;1/&γ;2 8HOC-H4-Imetit-Gi1/&β;1/&γ;2
27.78Consensusgi_nucleotideOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
27.78Consensusgs_histamineOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.78Consensush4_onOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.78Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
27.78Consensussmo_on_alloOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
27.59Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
27.27Single4AMIBucindolol4AMI-β1-Bucindolol
27.27Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
27.27Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
27.27Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
27.27Single7DFPSpiperone7DFP-D2-Spiperone
27.27Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
27.27Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
27.27Single7WCNAR2314537WCN-GPR119-AR231453-Gs/&β;1/&γ;2
27.27Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
27.27Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
27.27Single7YITNalfurafine7YIT-κ-Nalfurafine
27.27Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
27.27Single8I95EP548I95-C3aB-EP54-Go/&β;1/&γ;2
27.27Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2
27.27Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
27.27Single8JWZAB9288JWZ-A2A-AB928-Na
27.27Single8WU1KCA8WU1-CB1-KCA-Arrestin1
27.27Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
27.27Consensusgpr119_onOrthosteric Ligand7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
27.27Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
27.27Consensuspeptide_offOrthosteric Ligandopioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
27.27Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
26.67Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
26.67Single7XKEBetahydroxyandrosterone7XKE-ADGRG2-Betahydroxyandrosterone-chim(NtGi1-Gs)/&β;1/&γ;2
26.67Single8PWNTheophylline8PWN-A2A-Theophylline
26.67Consensusclass-c_onOther Ligandgabab_on mglu_on
26.32Single3UZCPubChem 1355666093UZC-A2A-PubChem 135566609
26.32Single4DKLBeta-funaltrexamine4DKL-μ-Beta-funaltrexamine
26.32Single4MBSMaraviroc4MBS-CCR5-Maraviroc
26.32Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
26.32Single5IU4ZM2413855IU4-A2A-ZM241385-Na
26.32Single5IUBQ274563445IUB-A2A-Q27456344-Na
26.32Single5K2BZM2413855K2B-A2A-ZM241385-Na
26.32Single5K2CZM2413855K2C-A2A-ZM241385-Na
26.32Single5NLXZM2413855NLX-A2A-ZM241385-Na
26.32Single5NM4ZM2413855NM4-A2A-ZM241385-Na
26.32Single5UVIZM2413855UVI-A2A-ZM241385
26.32Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
26.32Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
26.32Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
26.32Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
26.32Single6TPKRetosiban6TPK-OT-Retosiban
26.32Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
26.32Single6ZDVPubChem 9840736ZDV-A2A-PubChem 984073-Na
26.32Single7AROLUF58337ARO-A2A-LUF5833-Na
26.32Single7CMVPD1289077CMV-D3-PD128907-Gi1/&β;1/&γ;2
26.32Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2
26.32Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
26.32Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
26.32Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
26.32Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2
26.32Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
26.32Single7VODCariprazine7VOD-5-HT2A-Cariprazine
26.32Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
26.32Single7VVOPTH7VVO-PTH1-PTH-Gs/&β;1/&γ;2
26.32Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2
26.32Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
26.32Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.32Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/&β;1/&γ;2
26.32Consensus5ht2a_onOrthosteric Ligand7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.32Consensusalpha2b_onOrthosteric Ligand6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
26.32Consensusdop_off_alloOrthosteric Ligand4N6H-δ-Naltrindole-Na
26.32Consensusffa2_onOrthosteric Ligand8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
26.32Consensush3_on_alloOrthosteric Ligand7F61-H3-PF-03654746-Cholesterol
26.32Consensusm1_off_alloOrthosteric Ligand6WJC-M1-Atropine-Muscarinic toxin 7
26.32Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
26.32Consensusvasopressin-ot_offOrthosteric Ligandot_off
26.09Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
26.09Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
26.09Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
26.09Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
26.09Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
26.09Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/&β;1/&γ;2
26.09Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
26.09Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/&β;1/&γ;2
26.09Single8ID8TUG-8918ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
26.09Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.09Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
26.09Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.09Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
26.09Consensusbeta1_off_alloOrthosteric Ligand4BVN-β1-Cyanopindolol-Na
26.09Consensusbileacid_onOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
26.09Consensusfpa_onOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.09Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
26.09Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
26.09Consensussteroid_onOrthosteric Ligandbileacid_on
25.93Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
25.93Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
25.93Single7C61Ergotamine7C61-5-HT1B-Ergotamine
25.93Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
25.81Consensusgs_crfOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
25.00Single3NY8ICI 118-5513NY8-β2-ICI 118-551
25.00Single3NYA(S)-Alprenolol3NYA-β2-(S)-Alprenolol
25.00Single3RFMCaffeine3RFM-A2A-Caffeine
25.00Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
25.00Single4DAJTiotropium4DAJ-M3-Tiotropium
25.00Single4GBR(S)-Carazolol4GBR-β2-(S)-Carazolol
25.00Single4MQSIperoxo4MQS-M2-Iperoxo
25.00Single4U14Tiotropium4U14-M3-Tiotropium
25.00Single4U16N-Methyl Scopolamine4U16-M3-N-Methyl Scopolamine
25.00Single5DSGTiotropium5DSG-M4-Tiotropium
25.00Single5EE7MK08935EE7-Glucagon-MK0893
25.00Single5UENDU1725UEN-A1-DU172
25.00Single5YC8N-Methyl Scopolamine5YC8-M2-N-Methyl Scopolamine
25.00Single5ZK8N-Methyl Scopolamine5ZK8-M2-N-Methyl Scopolamine
25.00Single5ZKCN-Methyl Scopolamine5ZKC-M2-N-Methyl Scopolamine
25.00Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
25.00Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
25.00Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
25.00Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
25.00Single6LPJZM2413856LPJ-A2A-ZM241385-Na
25.00Single6LPKZM2413856LPK-A2A-ZM241385-Na
25.00Single6PS0(S)-Carazolol6PS0-β2-(S)-Carazolol
25.00Single6PS2(S)-Alprenolol6PS2-β2-(S)-Alprenolol
25.00Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
25.00Single6PT3DPI-2876PT3-δ-DPI-287
25.00Single6TOTLemborexant6TOT-OX1-Lemborexant
25.00Single7CFMP3957CFM-GPBA-P395-Gs/&β;1/&γ;2
25.00Single7CRHSKF839597CRH-D1-SKF83959-Gs/&β;1/&γ;2
25.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
25.00Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
25.00Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
25.00Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
25.00Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
25.00Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
25.00Single7SK9CCX6627SK9-ACKR3-CCX662
25.00Single7T2GMitragynine pseudoindoxyl7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
25.00Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
25.00Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/&β;1/&γ;2
25.00Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
25.00Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
25.00Single7XKDBetahydroxyandrosterone7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
25.00Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
25.00Single7XY6PubChem 117178317XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
25.00Single8A2OTheophylline8A2O-A2A-Theophylline-Na
25.00Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
25.00Single8EFQDamgo8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
25.00Single8JJOAlprenolol8JJO-β2-Alprenolol
25.00Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
25.00Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
25.00Single8WC5Tetramethylammonium ion8WC5-TA1-Tetramethylammonium ion-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single8X63Mepyramine8X63-H1-Mepyramine
25.00Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
25.00Consensusalpha2_onOrthosteric Ligandalpha2a_on alpha2b_on
25.00Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
25.00Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2 8I95-C3aB-EP54-Go/&β;1/&γ;2
25.00Consensusclass-d_offOrthosteric Ligandste2_off
25.00Consensusgo_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
25.00Consensushistamine_onOrthosteric Ligandh1_on h4_on
25.00Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
25.00Consensusm2_on_alloOrthosteric Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
25.00Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
25.00Consensusm4_on_alloOrthosteric Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
25.00Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
25.00Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
25.00Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
25.00Consensustachykinin_offOrthosteric Ligandnk1_off
25.00Consensustar_onOrthosteric Ligandta1_on
24.24Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
24.14Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
24.14Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
24.14Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
24.14Consensusclass-d_onOrthosteric Ligandste2_on
24.14Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
24.00Single4AMJ(S)-Carvedilol4AMJ-β1-(S)-Carvedilol
24.00Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
24.00Single7QA8Peptide7QA8-STE2-Peptide
24.00Single7QA8Peptide7QA8-STE2-Peptide
24.00Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
24.00Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
24.00Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
24.00Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
24.00Single8GHVPubChem 1459649038GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
24.00Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
24.00Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
24.00Consensusclass-d_offOrthosteric Ligandste2_off
24.00Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
24.00Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
23.81Single2RH1(S)-Carazolol2RH1-β2-(S)-Carazolol
23.81Single2YCW(S)-Carazolol2YCW-β1-(S)-Carazolol
23.81Single4JKVTaladegib (LY2940680)4JKV-SMO-Taladegib (LY2940680)
23.81Single4WW3All-trans-retinal4WW3-Rhodopsin-All-trans-retinal
23.81Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
23.81Single5D6L(S)-Carazolol5D6L-β2-(S)-Carazolol
23.81Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
23.81Single6PS6Timolol6PS6-β2-Timolol
23.81Single6TP6Filorexant6TP6-OX1-Filorexant
23.81Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
23.81Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
23.81Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
23.81Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2
23.81Single7WC6LSD7WC6-5-HT2A-LSD
23.81Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.81Single7Y27Somatostatin-147Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.81Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
23.81Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
23.81Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
23.81Consensusadrenergic_offOrthosteric Ligandbeta_off alpha_off
23.81Consensusalpha2a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
23.81Consensusamine_offOrthosteric Ligandadrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
23.81Consensusbeta2_offOrthosteric Ligand6PS2-β2-(S)-Alprenolol 6PS3-β2-(S)-Carvedilol 6PS5-β2-(S)-Propranolol 6PS6-β2-Timolol 2RH1-β2-(S)-Carazolol 6PS4-β2-ICI 118-551 3NY9-β2-PubChem 913103
23.81Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
23.81Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRR-D1-Rotigotine-Gs/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
23.81Consensusgo_amineOrthosteric Ligandgo_adrenergic go_muscarinic go_5ht
23.81Consensusgs_muscarinicOrthosteric Ligand8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.81Consensusgs_sstOrthosteric Ligand7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.81Consensusm2_offOrthosteric Ligand5ZKB-M2-AF-DX 384 5ZKC-M2-N-Methyl Scopolamine 5ZK3-M2-Quinuclidinyl benzilate hydrobromide
23.81Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.81Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
23.53Single3UZAGTPL92363UZA-A2A-GTPL9236
23.53Single5WKTOctyl Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
23.53Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
23.53Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2
23.53Single7MT8All-trans-retinal7MT8-Rhodopsin-All-trans-retinal-GRK1
23.53Single7MT9All-trans-retinal7MT9-Rhodopsin-All-trans-retinal-GRK1
23.53Single7MTAAll-trans-retinal7MTA-Rhodopsin-All-trans-retinal-GRK1
23.53Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/&β;1/&γ;2
23.53Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
23.33Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
23.33Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
23.33Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
23.33Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
23.33Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
23.33Consensusgi_class-dOrthosteric Ligandgi_ste
23.33Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
23.08Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
23.08Single6HLOAprepitant6HLO-NK1-Aprepitant
23.08Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
23.08Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
22.73Single4RWADIPP-NH24RWA-δ-DIPP-NH2
22.73Single4U15Tiotropium4U15-M3-Tiotropium
22.73Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
22.73Single5D5A(S)-Carazolol5D5A-β2-(S)-Carazolol
22.73Single5D5B(S)-Carazolol5D5B-β2-(S)-Carazolol
22.73Single5V57TC1145V57-SMO-TC114
22.73Single5XRAAM115425XRA-CB1-AM11542
22.73Single6E59L-7607356E59-NK1-L-760735
22.73Single6J20Aprepitant6J20-NK1-Aprepitant
22.73Single6OL9Tiotropium6OL9-M5-Tiotropium
22.73Single6TQ7SB-3348676TQ7-OX1-SB-334867
22.73Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
22.73Single6WGTLSD6WGT-5-HT2A-LSD
22.73Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2
22.73Single7FEEPubMed 1048957FEE-CB1-PubMed 104895-ZCZ011
22.73Single7JVPSKF839597JVP-D1-SKF83959-Gs/&β;1/&γ;2
22.73Single7P2L4YI7P2L-mGlu5-4YI
22.73Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
22.73Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
22.73Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
22.73Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
22.73Single7W41PD1762527W41-BB2-PD176252
22.73Single7W6PW967W6P-α2a-W96-Go/&β;1/&γ;2
22.73Single7W7EW587W7E-α2a-W58-Go/&β;1/&γ;2
22.73Single7WV9PubMed 1048957WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
22.73Single7XTQR3997XTQ-GPBA-R399-Gs/&β;1/&γ;2
22.73Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2
22.73Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/&β;1/&γ;2
22.73Single8DZPmomSalB8DZP-κ-momSalB-Gi1/&β;1/&γ;2
22.73Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
22.73Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
22.73Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/&β;1/&γ;2
22.73Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.73Single8JXWVUF68848JXW-H4-VUF6884-Gi1/&β;1/&γ;2
22.73Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
22.73Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.73Single8X79MRE-2698X79-I2-MRE-269-Gs/&β;1/&γ;2
22.73Consensus5ht5_offOrthosteric Ligand5ht5a_off
22.73Consensus5ht_offOrthosteric Ligand5ht2_off 5ht5_off 5ht1_off
22.73Consensusangiotensin_offOrthosteric Ligandat1_off at2_off
22.73Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
22.73Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
22.73Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCZ-β1-Iodocyanopindolol
22.73Consensusbombesin_offOrthosteric Ligandbb2_off
22.73Consensuscck_onOrthosteric Ligandccka_on cckb_on
22.73Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
22.73Consensusdopamine_offOrthosteric Ligandd3_off d2_off d4_off
22.73Consensusffa4_onOrthosteric Ligand8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
22.73Consensusgi_dopamineOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
22.73Consensusgo_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
22.73Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2
22.73Consensusgs_ffaOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2 8GDB-EP4-PGE2-Gs/&β;1/&γ;2
22.73Consensush1_offOrthosteric Ligand3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole 8X63-H1-Mepyramine 8X64-H1-Desloratadine
22.73Consensushistamine_offOrthosteric Ligandh1_off
22.73Consensuslpa_offOrthosteric Ligandlpa1_off
22.73Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl Scopolamine 5ZHP-M3-PubChem 134828589
22.73Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
22.73Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
22.73Consensusnk1_offOrthosteric Ligand6J20-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
22.73Consensussst4_onOrthosteric Ligand7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
22.58Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
22.58Single6IGLIRL16206IGL-ETB-IRL1620
22.58Single6LMLGlucagon6LML-Glucagon-Glucagon
22.58Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
22.58Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
22.58Single8FEGPRD_0025178FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
22.58Consensuscrf1_onOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
22.58Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
22.58Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
22.22Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
22.22Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
22.22Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
22.22Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
22.22Single6PT2KGCHM076PT2-δ-KGCHM07
22.22Single6QNOAll-trans-retinal6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
22.22Single6W25SHU91196W25-MC4-SHU9119-Ca
22.22Single7F4DAlpha-MSH7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
22.22Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
22.22Single7SRQLSD7SRQ-5-HT2B-LSD
22.22Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
22.22Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
22.22Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
22.22Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;2
22.22Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/&β;1/&γ;2
22.22Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2
22.22Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.22Single8HN8Histamine8HN8-H4-Histamine-Gi1/&β;1/&γ;2
22.22Single8ITFDMCHA8ITF-TAAR9-DMCHA-chim(NtGi1-Gs)/&β;1/&γ;2
22.22Single8IY9Niacin8IY9-HCA2-Niacin-Go/&β;1/&γ;2
22.22Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
22.22Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
22.22Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
22.22Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/&β;1/&γ;2
22.22Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
22.22Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
21.88Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
21.88Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
21.88Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
21.74Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
21.74Single3D4STimolol Maleate3D4S-β2-Timolol Maleate
21.74Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
21.74Single5CXVTiotropium5CXV-M1-Tiotropium
21.74Single6A93Risperidone6A93-5-HT2A-Risperidone
21.74Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
21.74Single6CM4Risperidone6CM4-D2-Risperidone
21.74Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
21.74Single6KQIPubMed 1048956KQI-CB1-PubMed 104895-ORG27569
21.74Single6MXTSalmeterol6MXT-β2-Salmeterol
21.74Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
21.74Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
21.74Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
21.74Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/&β;1/&γ;2
21.74Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/&β;1/&γ;2
21.74Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
21.74Single7K15MKD0467K15-BLT1-MKD046-Na
21.74Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.74Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
21.74Single7XMTJ-21567XMT-SST4-J-2156-Gi1/&β;1/&γ;2
21.74Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
21.74Single7Y24Octreotide7Y24-SST2-Octreotide-Go/&β;1/&γ;2
21.74Single8GCPPGE28GCP-EP4-PGE2-Gi1/&β;1/&γ;2
21.74Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2
21.74Single8IBUErythromycin A8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.74Single8JJLOlodaterol8JJL-β2-Olodaterol
21.74Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/&β;1/&γ;2
21.74Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.74Consensusat2_offOrthosteric Ligand7JNI-AT2-Olodanrigan
21.74Consensusblt1_offOrthosteric Ligand7K15-BLT1-MKD046-Na
21.74Consensusblt_offOrthosteric Ligandblt1_off
21.74Consensuscb1_off_alloOrthosteric Ligand6KQI-CB1-PubMed 104895-ORG27569
21.74Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
21.74Consensusgi_prostanoidOrthosteric Ligand8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GDC-EP3-PGE2-Gi1/&β;1/&γ;2 8GCM-EP4-L902688-Gi1/&β;1/&γ;2
21.74Consensusgs_bileacidOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
21.74Consensusgs_steroidOrthosteric Ligandgs_bileacid
21.74Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
21.74Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
21.74Consensusprostanoid_onOrthosteric Ligandep_on fpa_on
21.74Consensustsh_on_alloOther Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
21.43Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
21.43Single6JODAngiotensin II6JOD-AT2-Angiotensin II
21.43Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
21.43Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
21.43Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
21.43Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
21.43Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
21.43Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.43Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.43Consensusgi_somatostatinOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
21.43Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
21.43Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
21.43Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
21.43Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
21.21Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
21.21Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
21.05Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
21.05Single2X72All-trans-retinal2X72-Rhodopsin-All-trans-retinal-Gt(CT)
21.05Single3VG9ZM2413853VG9-A2A-ZM241385-Antibody
21.05Single4S0VSuvorexant4S0V-OX2-Suvorexant
21.05Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
21.05Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
21.05Single6AKYMaraviroc6AKY-CCR5-Maraviroc
21.05Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
21.05Single6TODEMPA6TOD-OX1-EMPA-Na
21.05Single6TPJSuvorexant6TPJ-OX2-Suvorexant
21.05Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
21.05Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
21.05Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
21.05Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
21.05Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
21.05Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
21.05Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.05Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
21.05Single7TUZ7alpha,25-dihydroxycholesterol7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
21.05Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
21.05Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2
21.05Single8GEDEpinephrine8GED-β2-Epinephrine-Gs/&β;1/&γ;2
21.05Single8GG9Epinephrine8GG9-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.05Single8GGFEpinephrine8GGF-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.05Single8HMPPubChem 699214798HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
21.05Single8IW4Spermidine8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2
21.05Single8IWESpermidine8IWE-TAAR9-Spermidine
21.05Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/&β;1/&γ;2
21.05Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
21.05Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.05Single8UNLEpinephrine8UNL-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.05Single8UNTEpinephrine8UNT-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.05Single8UNUEpinephrine8UNU-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.05Single8UNWEpinephrine8UNW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.05Single8UO0Epinephrine8UO0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.05Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
21.05Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
21.05Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
21.05Consensusalpha1_onOrthosteric Ligandalpha1a_on
21.05Consensusalpha1a_onOrthosteric Ligand7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.05Consensusorexin_offOrthosteric Ligandox2_off ox1_off
20.83Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
20.83Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
20.83Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
20.83Single6IBLArformoterol6IBL-β1-Arformoterol
20.83Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2
20.83Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
20.83Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
20.83Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.83Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
20.83Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
20.83Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
20.83Single7UM4AS26747237UM4-5-HT5A-AS2674723
20.83Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
20.83Single7XJISolabegron7XJI-β3-Solabegron-Gs/&β;1/&γ;2
20.83Single7XZ6APD6687XZ6-GPR119-APD668-Gs/&β;1/&γ;2
20.83Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
20.83Single8GAGYVF8GAG-CB1-YVF-Gi1/&β;1/&γ;2
20.83Single8WRZ8D08WRZ-CB1-8D0-Arrestin1
20.83Consensus5ht5a_offOrthosteric Ligand7UM4-5-HT5A-AS2674723
20.83Consensusadgrg2_onOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
20.83Consensusendothelin_offOrthosteric Ligandetb_off
20.83Consensusep4_onOrthosteric Ligand7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2
20.83Consensusetb_offOrthosteric Ligand5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500 5X93-ETB-K-8794
20.83Consensusgs_lipidOrthosteric Ligandgs_ffa gs_prostanoid
20.83Consensusgs_prostanoidOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.69Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
20.69Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
20.69Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
20.69Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
20.69Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
20.69Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
20.69Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
20.69Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.69Consensusbk1_onOrthosteric Ligand7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.69Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
20.69Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
20.69Consensusgs_bradykininOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.69Consensusgs_melanocortinOrthosteric Ligand7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2
20.69Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
20.59Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
20.00Single3REYPubChem 56973REY-A2A-PubChem 5697
20.00Single3RZECidoxepin3RZE-H1-Cidoxepin
20.00Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
20.00Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
20.00Single4ZJCSB-6740424ZJC-OX1-SB-674042
20.00Single5MZPCaffeine5MZP-A2A-Caffeine-Na
20.00Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
20.00Single6DS0Ly2660976DS0-5-HT2B-Ly266097
20.00Single6FFIMMPEP6FFI-mGlu5-MMPEP
20.00Single6FJ3PTH6FJ3-PTH1-PTH
20.00Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
20.00Single6PS4ICI 118-5516PS4-β2-ICI 118-551
20.00Single6PS5(S)-Propranolol6PS5-β2-(S)-Propranolol
20.00Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
20.00Single6TP3Nemorexant6TP3-OX1-Nemorexant
20.00Single6TPGEMPA6TPG-OX2-EMPA
20.00Single6TPNHTL66416TPN-OX2-HTL6641
20.00Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
20.00Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
20.00Single7BB6Acyclovir triphosphate7BB6-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
20.00Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/&β;1/&γ;2
20.00Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
20.00Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
20.00Single7D3SSecretin7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
20.00Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
20.00Single7F0TDopamine7F0T-D1-Dopamine-Gs/&β;1/&γ;2
20.00Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/&β;1/&γ;2
20.00Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
20.00Single7JOZVFP7JOZ-D1-VFP-Gs/&β;1/&γ;2
20.00Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
20.00Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
20.00Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
20.00Single7T32ZM2413857T32-A2A-ZM241385
20.00Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
20.00Single7XN9L-054,5227XN9-SST2-L-054,522
20.00Single7XOVSR1461317XOV-CCKA-SR146131-Gs/&β;1/&γ;2
20.00Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
20.00Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
20.00Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
20.00Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
20.00Single8GEGEpinephrine8GEG-β2-Epinephrine-Gs/&β;1/&γ;2
20.00Single8GG3Epinephrine8GG3-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
20.00Single8GG5Epinephrine8GG5-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
20.00Single8GGKEpinephrine8GGK-β2-Epinephrine
20.00Single8GGLEpinephrine8GGL-β2-Epinephrine
20.00Single8GGMEpinephrine8GGM-β2-Epinephrine
20.00Single8GGPEpinephrine8GGP-β2-Epinephrine
20.00Single8GGQEpinephrine8GGQ-β2-Epinephrine
20.00Single8GURPubChem 1048958GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2
20.00Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
20.00Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Single8JERAcipimox8JER-HCA2-Acipimox-Go/&β;1/&γ;2
20.00Single8JHNMMF8JHN-HCA2-MMF-Go/&β;1/&γ;2
20.00Single8JIMMMF8JIM-HCA2-MMF-Gi1/&β;1/&γ;2
20.00Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
20.00Single8JLNT1AM8JLN-TA1-T1AM-Gs/&β;1/&γ;2
20.00Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
20.00Single8K4NVF08K4N-GPR34-VF0-Gi1/&β;1/&γ;2
20.00Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Single8UHBRO52563908UHB-TA1-RO5256390-Gs/&β;1/&γ;2
20.00Single8UNREpinephrine8UNR-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
20.00Single8UNSEpinephrine8UNS-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
20.00Single8UNZEpinephrine8UNZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
20.00Single8UO2Epinephrine8UO2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
20.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
20.00Single8X5YAstemizole8X5Y-H1-Astemizole
20.00Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/&β;1/&γ;2
20.00Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
20.00Consensus5ht5_onOrthosteric Ligand5ht5a_on
20.00Consensus5ht5a_onOrthosteric Ligand7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
20.00Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
20.00Consensusd1_on_alloOrthosteric Ligand7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
20.00Consensusd3_onOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
20.00Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
20.00Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
20.00Consensusgo_vasopressinOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
20.00Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
20.00Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
20.00Consensusgs_tarOrthosteric Ligand8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Consensushca_onOrthosteric Ligandhca2_on hca3_on
20.00Consensushcar_onOrthosteric Ligandhca_on
20.00Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
20.00Consensuslh_on_alloOther Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Consensuslpl_offOrthosteric Ligands1p_off lpa_off
20.00Consensuslpl_onOrthosteric Ligands1p_on lpa_on
20.00Consensusm1_off_alloOther Ligand6WJC-M1-Atropine-Muscarinic toxin 7
20.00Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
20.00Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
20.00Consensusox1_offOrthosteric Ligand6TOT-OX1-Lemborexant 6TP4-OX1-ACT-462206 6TP6-OX1-Filorexant 6V9S-OX1-GTPL11403 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ7-OX1-SB-334867 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant
20.00Consensusox2_offOrthosteric Ligand6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant
20.00Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
20.00Consensussensory_offOrthosteric Ligandopsin_off
19.44Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
19.44Consensuspth_onOrthosteric Ligandpth1_on pth2_on
19.35Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
19.35Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
19.35Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
19.35Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.35Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
19.35Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
19.35Consensusendothelin_onOrthosteric Ligandetb_on eta_on
19.35Consensusgo_class-b1Orthosteric Ligandgo_crf
19.35Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
19.23Single4IARErgotamine4IAR-5-HT1B-Ergotamine
19.23Single7F8XNN90567F8X-CCKA-NN9056
19.23Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
19.23Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
19.23Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
19.23Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
19.23Single8G59TUG-8918G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
19.23Single8J6RMK68928J6R-HCA2-MK6892-Gi1/&β;1/&γ;2
19.23Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
19.23Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
19.23Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
19.23Consensusfpr-alx_onOrthosteric Ligandfpr1-alx_on fpr2-alx_on
19.23Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
19.23Consensussst2_onOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
19.23Consensussst_onOrthosteric Ligandsst2_on sst4_on
19.05Single2Y02Carmoterol2Y02-β1-Carmoterol
19.05Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
19.05Single5JQH(S)-Carazolol5JQH-β2-(S)-Carazolol
19.05Single5UIGJ3.651.884G5UIG-A2A-J3.651.884G
19.05Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
19.05Single6DRXLisuride6DRX-5-HT2B-Lisuride
19.05Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
19.05Single6FFHFenobam6FFH-mGlu5-Fenobam
19.05Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2
19.05Single6PS1Timolol6PS1-β2-Timolol
19.05Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
19.05Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
19.05Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
19.05Single7F83PF-051904577F83-Ghrelin-PF-05190457
19.05Single7LJCPubChem 867641037LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
19.05Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
19.05Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/&β;1/&γ;2
19.05Single7UL4Alvimopan7UL4-μ-Alvimopan
19.05Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
19.05Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
19.05Single7WC7Lisuride7WC7-5-HT2A-Lisuride
19.05Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
19.05Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
19.05Single8EJCTAK-8758EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
19.05Single8GE3Epinephrine8GE3-β2-Epinephrine-Gs/&β;1/&γ;2
19.05Single8GEEEpinephrine8GEE-β2-Epinephrine-Gs/&β;1/&γ;2
19.05Single8GEHEpinephrine8GEH-β2-Epinephrine-Gs/&β;1/&γ;2
19.05Single8GFWEpinephrine8GFW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
19.05Single8GFXEpinephrine8GFX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
19.05Single8GFYEpinephrine8GFY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
19.05Single8GFZEpinephrine8GFZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
19.05Single8GG0Epinephrine8GG0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
19.05Single8GG1Epinephrine8GG1-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
19.05Single8GG2Epinephrine8GG2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
19.05Single8GG6Epinephrine8GG6-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
19.05Single8GGBEpinephrine8GGB-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
19.05Single8GGJEpinephrine8GGJ-β2-Epinephrine
19.05Single8GGNEpinephrine8GGN-β2-Epinephrine
19.05Single8GGOEpinephrine8GGO-β2-Epinephrine
19.05Single8GGUEpinephrine8GGU-β2-Epinephrine
19.05Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
19.05Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2
19.05Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
19.05Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2
19.05Single8JLZST19368JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
19.05Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
19.05Single8UNMEpinephrine8UNM-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
19.05Single8UNNEpinephrine8UNN-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
19.05Single8UNPEpinephrine8UNP-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
19.05Single8UO4Epinephrine8UO4-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
19.05Single8X64Desloratadine8X64-H1-Desloratadine
19.05Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-alpha-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
19.05Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
19.05Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
19.05Consensusadrenergic_onOrthosteric Ligandbeta_on alpha_on
19.05Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
19.05Consensusamine_onOrthosteric Ligandadrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on
19.05Consensusdopamine_onOrthosteric Ligandd3_on d2_on d5_on d1_on
19.05Consensusffa_onOrthosteric Ligandffa4_on ffa1_on ffa2_on ffa3_on
19.05Consensusgi_hcaOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
19.05Consensusgi_hcarOrthosteric Ligandgi_hca
19.05Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
19.05Consensushca2_onOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
19.05Consensushca3_onOrthosteric Ligand8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
19.05Consensussmo_offOrthosteric Ligand5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
18.75Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
18.75Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
18.75Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
18.75Single7VGXNeuropeptide Y7VGX-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
18.75Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
18.75Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
18.75Consensusgs_endothelinOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.75Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
18.75Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
18.75Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
18.52Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
18.52Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
18.52Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
18.52Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/&β;1/&γ;2
18.52Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
18.52Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
18.52Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
18.52Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
18.52Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
18.52Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
18.52Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.52Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
18.52Consensusalpha1_offOrthosteric Ligandalpha1a_off alpha1b_off
18.52Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
18.52Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
18.42Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
18.18Single5C1MBU725C1M-μ-BU72
18.18Single5CGCHTL142425CGC-mGlu5-HTL14242
18.18Single5GLHEndothelin-15GLH-ETB-Endothelin-1
18.18Single5TVNLSD5TVN-5-HT2B-LSD
18.18Single5WQCEMPA5WQC-OX2-EMPA
18.18Single5XPRBosentan5XPR-ETB-Bosentan
18.18Single6D26Fevipiprant6D26-DP2-Fevipiprant
18.18Single6DDEDamgo6DDE-μ-Damgo-Gi1/&β;1/&γ;2
18.18Single6E67BI1671076E67-β2-BI167107-Gs (fused)
18.18Single6IGKEndothelin-36IGK-ETB-Endothelin-3
18.18Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
18.18Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
18.18Single6LUQHaloperidol6LUQ-D2-Haloperidol
18.18Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
18.18Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
18.18Single6PS3(S)-Carvedilol6PS3-β2-(S)-Carvedilol
18.18Single7BVQ(S)-Carazolol7BVQ-β1-(S)-Carazolol
18.18Single7CKXA776367CKX-D1-A77636-Gs/&β;1/&γ;2
18.18Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
18.18Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2
18.18Single7SBFPZM217SBF-μ-PZM21-Gi1/&β;1/&γ;2
18.18Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
18.18Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
18.18Single7XKAEpinephrine7XKA-β2-Epinephrine
18.18Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
18.18Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
18.18Single8DZQmomSalB8DZQ-κ-momSalB-Go/&β;1/&γ;2
18.18Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
18.18Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2
18.18Single8GDAL9026888GDA-EP4-L902688-Gs/&β;1/&γ;2
18.18Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2
18.18Single8ID9Eicosapentaenoic acid8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
18.18Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
18.18Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
18.18Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
18.18Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
18.18Single8QOTNanobody E8QOT-μ-Nanobody E
18.18Single8UNYEpinephrine8UNY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
18.18Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
18.18Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide 6DRX-5-HT2B-Lisuride
18.18Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
18.18Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
18.18Consensusbeta2_onOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
18.18Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
18.18Consensuscb2_onOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
18.18Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
18.18Consensusgi_adrenergicOrthosteric Ligand7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
18.18Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
18.18Consensusgo_opioidOrthosteric Ligand8DZQ-κ-momSalB-Go/&β;1/&γ;2
18.18Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
18.18Consensusgs_adrenergicOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJI-β3-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
18.18Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
17.86Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
17.86Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1
17.86Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
17.86Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
17.86Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
17.86Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.86Consensusangiotensin_onOrthosteric Ligandat1_on
17.86Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
17.86Consensusgi_chemerinOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
17.86Consensusgi_formylpeptideOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
17.86Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
17.86Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.86Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.65Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
17.65Single6OY9All-trans-retinal6OY9-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
17.65Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.65Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
17.65Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
17.65Consensusglp_onOrthosteric Ligandglp1_on glp2_on
17.65Consensushca2_on_alloOrthosteric Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
17.65Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
17.39Single3P0GBI1671073P0G-β2-BI167107
17.39Single3SN6BI1671073SN6-β2-BI167107-Gs/&β;1/&γ;2
17.39Single4DJHJDTic4DJH-κ-JDTic
17.39Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
17.39Single5TZR-5TZR-FFA1 (GPR40)-MK8666
17.39Single5V54Methiothepin5V54-5-HT1B-Methiothepin
17.39Single5X93K-87945X93-ETB-K-8794
17.39Single5XR8AM8415XR8-CB1-AM841
17.39Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
17.39Single6H7JIsoprenaline6H7J-β1-Isoprenaline
17.39Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
17.39Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
17.39Single6NI3BI1671076NI3-β2-BI167107-Gs/&β;1/&γ;2
17.39Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
17.39Single7B6WCyclazosin7B6W-α1b-Cyclazosin
17.39Single7CKYPW04647CKY-D1-PW0464-Gs/&β;1/&γ;2
17.39Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
17.39Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
17.39Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2
17.39Single7JV5SKF812977JV5-D1-SKF81297-Gs/&β;1/&γ;2
17.39Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
17.39Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
17.39Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2
17.39Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
17.39Single7XOWGastrin7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
17.39Single7XOXCholecystokinin-87XOX-CCKB-Cholecystokinin-8-Gq/&β;1/&γ;2
17.39Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
17.39Single8E0GBU728E0G-μ-BU72
17.39Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
17.39Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
17.39Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.39Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2
17.39Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2
17.39Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
17.39Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/&β;1/&γ;2
17.39Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
17.39Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
17.39Consensus5ht1_offOrthosteric Ligand5ht1b_off
17.39Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
17.39Consensusalpha1b_offOrthosteric Ligand7B6W-α1b-Cyclazosin
17.39Consensuscyslt1_off_ortoalloOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
17.39Consensusgi_ffaOrthosteric Ligand8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
17.39Consensusgs_compl-peptideOrthosteric Ligand8I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.39Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
17.39Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
17.39Consensuslpa_onOrthosteric Ligandlpa1_on
17.39Consensusmglu2_onOther Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
17.39Consensusnpy_offOrthosteric Ligandnpy2_off npy1_off
17.39Consensusrelaxin_onOrthosteric Ligandrxfp4_on
17.39Consensuss1p2_onOrthosteric Ligand7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
17.39Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
17.39Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
17.24Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
17.24Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
17.24Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
17.24Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
17.24Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
17.24Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
17.24Single8IHFMK68928IHF-HCA2-MK6892-Gi1/&β;1/&γ;2
17.24Single8J6IMK68928J6I-HCA2-MK6892-Gi1/&β;1/&γ;2
17.24Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
17.24Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
17.14Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
17.14Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
17.14Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
16.67Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
16.67Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
16.67Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
16.67Single3OE6IT1t3OE6-CXCR4-IT1t
16.67Single3PQRAll-trans-retinal3PQR-Rhodopsin-All-trans-retinal-Gt(CT)
16.67Single4LDEBI1671074LDE-β2-BI167107
16.67Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
16.67Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
16.67Single6H7N(S)-Xamoterol6H7N-β1-(S)-Xamoterol
16.67Single6HLPNetupitant6HLP-NK1-Netupitant
16.67Single6IIURamatroban6IIU-TP-Ramatroban
16.67Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
16.67Single6LI0GTPL98046LI0-GPR52-GTPL9804
16.67Single6ME5Agomelatine6ME5-MT1-Agomelatine
16.67Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
16.67Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
16.67Single6ZG4HTL00099366ZG4-M1-HTL0009936
16.67Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1
16.67Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
16.67Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/&β;1/&γ;2
16.67Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2
16.67Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
16.67Single7S8O(R)-Zinc-35737S8O-MRGPRX2-(R)-Zinc-3573-Gi1/&β;1/&γ;2
16.67Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
16.67Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
16.67Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
16.67Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
16.67Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
16.67Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
16.67Single7WC5Psilocin7WC5-5-HT2A-Psilocin
16.67Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
16.67Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
16.67Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
16.67Single7Y66BM2137Y66-C5a1-BM213-Gi1/&β;1/&γ;2
16.67Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
16.67Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
16.67Single8GGREpinephrine8GGR-β2-Epinephrine
16.67Single8GGZEpinephrine8GGZ-β2-Epinephrine
16.67Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2
16.67Single8IJDMK68928IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
16.67Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single8IW72-Phenylethylamine8IW7-TAAR9-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
16.67Single8J6DEP1418J6D-C3aB-EP141-Go/&β;1/&γ;2
16.67Single8J6QBeta-hydroxybutyrate8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
16.67Single8JJ8Formoterol8JJ8-β2-Formoterol
16.67Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/&β;1/&γ;2
16.67Single8POKHistamine8POK-H2-Histamine-Gs/&β;1/&γ;2
16.67Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
16.67Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
16.67Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
16.67Consensusbombesin_onOrthosteric Ligandbb2_on bb1_on
16.67Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
16.67Consensuscannabinoid_onOrthosteric Ligandcb1_on cb2_on
16.67Consensuscb1_onOrthosteric Ligand8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
16.67Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
16.67Consensusdp_offOrthosteric Liganddp2_off
16.67Consensusep_onOrthosteric Ligandep4_on ep2_on ep3_on
16.67Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
16.67Consensusgi_cannabinoidOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
16.67Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
16.67Consensusgo_5htOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
16.67Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
16.67Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
16.67Consensusleuko_offOrthosteric Ligandblt_off cyslt_off
16.67Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
16.67Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
16.67Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
16.67Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
16.13Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
16.13Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
16.13Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/&β;1/&γ;2
16.13Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
16.13Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
16.13Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
16.13Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
16.13Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
16.13Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
16.13Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.13Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
16.13Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
16.13Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.13Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
16.13Consensusbb1_onOrthosteric Ligand8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.13Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
16.13Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
16.13Consensusghrh_onOrthosteric Ligand7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
16.13Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
16.13Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
16.13Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
16.00Single5CGDHTL142425CGD-mGlu5-HTL14242
16.00Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
16.00Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
16.00Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
16.00Single6DDFDamgo6DDF-μ-Damgo-Gi1/&β;1/&γ;2
16.00Single6H7LDobutamine6H7L-β1-Dobutamine
16.00Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
16.00Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
16.00Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
16.00Single7XK2MK68927XK2-HCA2-MK6892-Gi1/&β;1/&γ;2
16.00Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
16.00Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
16.00Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
16.00Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.00Consensusc5a1_off_ortoalloOrthosteric Ligand6C1Q-C5a1-PMX53-NDT9513727 6C1R-C5a1-PMX53-Avacopan; Na
16.00Consensuscckb_onOrthosteric Ligand7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
16.00Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
16.00Consensusffa4_on_alloOrthosteric Ligand8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.00Consensusgs_orexinOrthosteric Ligand7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
16.00Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.00Consensusorexin_onOrthosteric Ligandox2_on
16.00Consensusot_onOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
15.79Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
15.79Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
15.79Single2G87All-trans-retinal2G87-Rhodopsin-All-trans-retinal
15.79Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
15.79Single3OE9IT1t3OE9-CXCR4-IT1t
15.79Single5L7IVismodegib5L7I-SMO-Vismodegib
15.79Single6HLLCP999946HLL-NK1-CP99994
15.79Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
15.79Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
15.79Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
15.79Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2
15.79Single7S8N(R)-Zinc-35737S8N-MRGPRX2-(R)-Zinc-3573-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.79Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
15.79Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
15.79Single7XKFBetahydroxyandrosterone7XKF-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
15.79Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2
15.79Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/&β;1/&γ;2
15.79Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.79Single8EF6Morphine8EF6-μ-Morphine-Gi1/&β;1/&γ;2
15.79Single8GEIEpinephrine8GEI-β2-Epinephrine-Gs/&β;1/&γ;2
15.79Single8GGSEpinephrine8GGS-β2-Epinephrine
15.79Single8GGYEpinephrine8GGY-β2-Epinephrine
15.79Single8GH1Epinephrine8GH1-β2-Epinephrine
15.79Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2
15.79Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/&β;1/&γ;2
15.79Single8IJANiacin8IJA-HCA2-Niacin-Gi1/&β;1/&γ;2
15.79Single8JILNiacin8JIL-HCA2-Niacin-Gi1/&β;1/&γ;2
15.79Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
15.79Single8K5BNiacin8K5B-HCA2-Niacin
15.79Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
15.79Single8UNVEpinephrine8UNV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
15.79Single8UNXEpinephrine8UNX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
15.79Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
15.79Consensus5ht4_onOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
15.79Consensusmt1_onOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
15.79Consensusox1_off_alloOrthosteric Ligand6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na 6TO7-OX1-Suvorexant-Na
15.62Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
15.62Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
15.62Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
15.62Consensusetb_onOrthosteric Ligand8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
15.62Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
15.62Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
15.38Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
15.38Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.38Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
15.38Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
15.38Single8XZFWN5618XZF-Apelin-WN561-Gi1/&β;1/&γ;2
15.38Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
15.38Consensusfpr2-alx_onOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
15.38Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
15.38Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
15.38Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
15.38Consensusgs_bombesinOrthosteric Ligand8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.38Consensusmotilin_onOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.15Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
15.15Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
15.15Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
15.15Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
15.15Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
15.15Single8IY6Endothelin-18IY6-ETB-Endothelin-1
15.15Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
15.15Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
15.00Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
15.00Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
15.00Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
15.00Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
15.00Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
15.00Single3ODUIT1t3ODU-CXCR4-IT1t
15.00Single5WS3EMPA5WS3-OX2-EMPA
15.00Single6B73PubChem 1319551386B73-κ-PubChem 131955138
15.00Single6ME2Ramelteon6ME2-MT1-Ramelteon
15.00Single6OBA(S)-Alprenolol6OBA-β2-(S)-Alprenolol-GTPL11074
15.00Single6OYAAll-trans-retinal6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
15.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
15.00Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2
15.00Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/&β;1/&γ;2
15.00Single7F8ULintitript7F8U-CCKA-Lintitript
15.00Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;1
15.00Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
15.00Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
15.00Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
15.00Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
15.00Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
15.00Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
15.00Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2
15.00Single7XRRLemborexant7XRR-OX2-Lemborexant
15.00Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2
15.00Single8A6CAll-trans-retinal8A6C-Rhodopsin-All-trans-retinal
15.00Single8A6DAll-trans-retinal8A6D-Rhodopsin-All-trans-retinal
15.00Single8A6EAll-trans-retinal8A6E-Rhodopsin-All-trans-retinal
15.00Single8EFOPZM218EFO-μ-PZM21-Gi1/&β;1/&γ;2
15.00Single8GEAEpinephrine8GEA-β2-Epinephrine-Gs/&β;1/&γ;2
15.00Single8GECEpinephrine8GEC-β2-Epinephrine-Gs/&β;1/&γ;2
15.00Single8GEFEpinephrine8GEF-β2-Epinephrine-Gs/&β;1/&γ;2
15.00Single8GG7Epinephrine8GG7-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
15.00Single8GGAEpinephrine8GGA-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
15.00Single8GGVEpinephrine8GGV-β2-Epinephrine
15.00Single8GGWEpinephrine8GGW-β2-Epinephrine
15.00Single8GGXEpinephrine8GGX-β2-Epinephrine
15.00Single8GH0Epinephrine8GH0-β2-Epinephrine
15.00Single8IHKAcifran8IHK-HCA3-Acifran
15.00Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2
15.00Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
15.00Single8U8FPML8U8F-GPR3-PML-Gs/&β;1/&γ;2
15.00Single8UNOEpinephrine8UNO-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
15.00Single8UO1Epinephrine8UO1-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
15.00Single8UO3Epinephrine8UO3-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
15.00Consensus5ht2_onOrthosteric Ligand5ht2a_on 5ht2c_on
15.00Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
15.00Consensusalpha2_offOrthosteric Ligandalpha2a_off alpha2c_off
15.00Consensusbeta2_off_alloOrthosteric Ligand6OBA-β2-(S)-Alprenolol-GTPL11074
15.00Consensusclass-f_offOrthosteric Ligandsmo_off
15.00Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
15.00Consensusffa3_on_alloOrthosteric Ligand8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
15.00Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
15.00Consensusgs_5htOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2 7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2 7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.00Consensusgt_class-aOrthosteric Ligandgt_opsin
15.00Consensusgt_opsinOrthosteric Ligandgt_sensory
15.00Consensusgt_sensoryOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
15.00Consensusm2_on_alloOther Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
15.00Consensusmelatonin_onOrthosteric Ligandmt1_on mt2_on
15.00Consensusopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
15.00Consensusp2y_offOrthosteric Ligandp2y1_off p2y12_off
14.81Single4XT1Fractalkine4XT1-US28-Fractalkine
14.81Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
14.81Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
14.81Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/&β;1/&γ;1
14.81Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
14.81Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
14.81Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
14.81Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
14.81Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
14.81Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
14.71Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
14.71Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
14.29Single6A94Zotepine6A94-5-HT2A-Zotepine
14.29Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
14.29Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
14.29Single6V9SGTPL114036V9S-OX1-GTPL11403
14.29Single6VI4JDTic6VI4-κ-JDTic
14.29Single6ZG9GSK10347026ZG9-M1-GSK1034702
14.29Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
14.29Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
14.29Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
14.29Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
14.29Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
14.29Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
14.29Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
14.29Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
14.29Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
14.29Single7VV6C48/807VV6-MRGPRX2-C48/80
14.29Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
14.29Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
14.29Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
14.29Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
14.29Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
14.29Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
14.29Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
14.29Single8GCML9026888GCM-EP4-L902688-Gi1/&β;1/&γ;2
14.29Single8GDZEpinephrine8GDZ-β2-Epinephrine-Gs/&β;1/&γ;2
14.29Single8GE1Epinephrine8GE1-β2-Epinephrine-Gs/&β;1/&γ;2
14.29Single8GE4Epinephrine8GE4-β2-Epinephrine-Gs/&β;1/&γ;2
14.29Single8GE6Epinephrine8GE6-β2-Epinephrine-Gs/&β;1/&γ;2
14.29Single8GE7Epinephrine8GE7-β2-Epinephrine-Gs/&β;1/&γ;2
14.29Single8GE8Epinephrine8GE8-β2-Epinephrine-Gs/&β;1/&γ;2
14.29Single8GE9Epinephrine8GE9-β2-Epinephrine-Gs/&β;1/&γ;2
14.29Single8GFVEpinephrine8GFV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
14.29Single8GG4Epinephrine8GG4-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
14.29Single8GG8Epinephrine8GG8-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
14.29Single8GGIEpinephrine8GGI-β2-Epinephrine
14.29Single8GGTEpinephrine8GGT-β2-Epinephrine
14.29Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
14.29Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
14.29Single8HQN9(S)-HODE8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
14.29Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
14.29Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2
14.29Single8K5CAcipimox8K5C-HCA2-Acipimox
14.29Single8UNQEpinephrine8UNQ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
14.29Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Consensuscx3cr_onOrthosteric Ligandcx3cr1_on
14.29Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
14.29Consensuscxcr_onOrthosteric Ligandcxcr1_on cxcr2_on
14.29Consensusgi_melatoninOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
14.29Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
13.89Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
13.89Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
13.79Single3OE0CVX153OE0-CXCR4-CVX15
13.79Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
13.79Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
13.79Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
13.79Consensuscx3cr1_onOrthosteric Ligand7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
13.79Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
13.79Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
13.64Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
13.64Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
13.64Single2Y04Salbutamol2Y04-β1-Salbutamol
13.64Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
13.64Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
13.64Single4QKXPubChem 762106284QKX-β2-PubChem 76210628
13.64Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
13.64Single6D27CAY104716D27-DP2-CAY10471
13.64Single6H7MSalbutamol6H7M-β1-Salbutamol
13.64Single6IIVDaltroban6IIV-TP-Daltroban
13.64Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/&β;1/&γ;2
13.64Single6PRZ(S)-Alprenolol6PRZ-β2-(S)-Alprenolol
13.64Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
13.64Single7BU7BI1671077BU7-β1-BI167107
13.64Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
13.64Single7SCGFH2107SCG-μ-FH210-Gi1/&β;1/&γ;2
13.64Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2
13.64Single7V3ZPubMed 1048957V3Z-CB1-PubMed 104895
13.64Single7VKTLTB47VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
13.64Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
13.64Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
13.64Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
13.64Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
13.64Single8EJKTAK-8758EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
13.64Single8GEBEpinephrine8GEB-β2-Epinephrine-Gs/&β;1/&γ;2
13.64Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/&β;1/&γ;2
13.64Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/&β;1/&γ;2
13.64Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
13.64Single8K5DGSK2560738K5D-HCA2-GSK256073
13.64Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/&β;1/&γ;2
13.64Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/&β;1/&γ;2
13.64Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
13.64Consensusblt_onOrthosteric Ligandblt1_on
13.64Consensuscb1_on_alloOrthosteric Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
13.64Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
13.64Consensusgi_5htOrthosteric Ligand7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
13.64Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
13.64Consensusleuko_onOrthosteric Ligandblt_on
13.64Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
13.64Consensusp2y12_offOrthosteric Ligand4NTJ-P2Y12-AZD1283 7PP1-P2Y12-Selatogrel
13.64Consensusprostanoid_offOrthosteric Ligandep_off tp_off dp_off
13.64Consensustp_offOrthosteric Ligand6IIV-TP-Daltroban 6IIU-TP-Ramatroban
13.51Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
13.33Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
13.33Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
13.33Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
13.33Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
13.33Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
13.33Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
13.33Consensusclass-d_onOrthosteric Ligandste2_on
13.33Consensusgi_class-dOrthosteric Ligandgi_ste
13.33Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
13.33Consensusnmur2_onOrthosteric Ligand7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.33Consensusnmur_onOrthosteric Ligandnmur1_on nmur2_on
13.16Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
13.04Single2Y03Isoprenaline2Y03-β1-Isoprenaline
13.04Single4NTJAZD12834NTJ-P2Y12-AZD1283
13.04Single4PHUFasiglifam4PHU-FFA1 (GPR40)-Fasiglifam
13.04Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
13.04Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
13.04Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
13.04Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
13.04Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
13.04Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
13.04Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
13.04Single7C4SS1P7C4S-S1P3-S1P
13.04Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
13.04Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
13.04Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
13.04Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
13.04Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
13.04Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
13.04Single7YXAONO-54306087YXA-S1P5-ONO-5430608
13.04Single8FN1Neurotensin/neuromedin N8FN1-NTS1-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
13.04Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
13.04Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
13.04Consensusep_offOrthosteric Ligandep4_off
12.90Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
12.90Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.90Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
12.90Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
12.90Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.90Consensusgs_neuromedinOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.82Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
12.50Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
12.50Single4A4MAll-trans-retinal4A4M-Rhodopsin-All-trans-retinal-Gt(CT)
12.50Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
12.50Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
12.50Single4XT3Fractalkine4XT3-US28-Fractalkine
12.50Single5EN0All-trans-retinal5EN0-Rhodopsin-All-trans-retinal-Gt(CT)
12.50Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2
12.50Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2
12.50Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
12.50Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
12.50Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50Single8EFLSR170188EFL-μ-SR17018-Gi1/&β;1/&γ;2
12.50Single8FMZNeurotensin/neuromedin N8FMZ-NTS1-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.50Single8GDBPGE28GDB-EP4-PGE2-Gs/&β;1/&γ;2
12.50Single8GUSHU-3088GUS-CB2-HU-308-Gi1/&β;1/&γ;2
12.50Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
12.50Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
12.50Single8WCBCyclohexylammonium ion8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50Single8WCCCyclohexylammonium ion8WCC-TA1-Cyclohexylammonium ion
12.50Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
12.50Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
12.50Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
12.50Consensuschemerin_onOrthosteric Ligandcml1_on
12.50Consensuscml1_onOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
12.50Consensusgi_neuromedinOrthosteric Ligand7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
12.50Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
12.50Consensusnts1_on_alloOrthosteric Ligand8JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
12.20Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
12.12Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
12.12Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
12.12Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
12.12Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
12.12Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
12.00Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
12.00Single6OS2TRV0266OS2-AT1-TRV026
12.00Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/&β;1/&γ;2
12.00Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
12.00Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/&β;1/γ1
12.00Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
12.00Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
12.00Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
12.00Single8JPBNeurotensin 8-138JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
12.00Consensusbeta1_onOrthosteric Ligand7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
12.00Consensuschemokine_offOrthosteric Ligandcxcr_off
12.00Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II
12.00Consensuscxcr_offOrthosteric Ligandcxcr4_off
12.00Consensusgs_trhOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
12.00Consensusnts1_onOrthosteric Ligand6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
12.00Consensusnts_onOrthosteric Ligandnts1_on
12.00Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
11.76Single3PXOAll-trans-retinal3PXO-Rhodopsin-All-trans-retinal
11.76Single5DYSAll-trans-retinal5DYS-Rhodopsin-All-trans-retinal
11.76Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
11.76Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
11.76Single7WC4Serotonin7WC4-5-HT2A-Serotonin
11.76Single8GEJEpinephrine8GEJ-β2-Epinephrine-Gs/&β;1/&γ;2
11.76Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
11.76Consensusgabab_offOther Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
11.54Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
11.54Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
11.54Single6K1QIRL25006K1Q-ETB-IRL2500
11.54Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/&β;1/&γ;2
11.54Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
11.54Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
11.54Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2
11.54Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
11.54Consensuscyslt2_offOrthosteric Ligand6RZ6-CysLT2-ONO-2570366 6RZ9-CysLT2-ONO-2770372 6RZ8-CysLT2-ONO-2080365
11.54Consensuscyslt_offOrthosteric Ligandcyslt2_off
11.54Consensusep2_onOrthosteric Ligand7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
11.54Consensusgi_neurotensinOrthosteric Ligand7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
11.43Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
11.11Single2HPYAll-trans-retinal2HPY-Rhodopsin-All-trans-retinal
11.11Single6KNMJN241-96KNM-Apelin-JN241-9
11.11Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
11.11Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
11.11Single7MTBAll-trans-retinal7MTB-Rhodopsin-All-trans-retinal-GRK1
11.11Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.11Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
11.11Single7VDMSubstance P7VDM-MRGPRX2-Substance P-Gi1/&β;1/&γ;2
11.11Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.11Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
11.11Single8IWM2-Phenylethylamine8IWM-TAAR9-2-Phenylethylamine
11.11Single8IYHMK68928IYH-HCA2-MK6892-Go/&β;1/&γ;2
11.11Single8SAI1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
11.11Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/&β;1/&γ;2
11.11Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
11.11Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
11.11Consensussensory_onOrthosteric Ligandopsin_on
11.11Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
10.81Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
10.71Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
10.71Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
10.71Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
10.71Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
10.71Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
10.71Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
10.53Single3OE8IT1t3OE8-CXCR4-IT1t
10.53Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
10.53Single6ME9Ramelteon6ME9-MT2-Ramelteon
10.53Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
10.53Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.53Single8EITDoconexent8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
10.53Consensusadgrg3_onOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
10.53Consensusopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
10.53Consensussmo_off_alloOrthosteric Ligand6D32-SMO-Cyclopamine-Cyclopamine
10.34Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
10.34Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.00Single3AYMAll-trans-retinal3AYM-Rhodopsin-All-trans-retinal
10.00Single3PBLEticlopride3PBL-D3-Eticlopride
10.00Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
10.00Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
10.00Single6TP4ACT-4622066TP4-OX1-ACT-462206
10.00Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
10.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
10.00Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
10.00Single7XNACYN1548067XNA-SST2-CYN154806
10.00Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
10.00Single8GGCEpinephrine8GGC-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
10.00Single8GGEEpinephrine8GGE-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
10.00Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2
10.00Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
10.00Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
10.00Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
10.00Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
10.00Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
10.00Consensusm4_on_alloOther Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
10.00Consensusmc5_onOrthosteric Ligand8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
10.00Consensusmt2_onOrthosteric Ligand7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
10.00Consensussmo_on_alloOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
10.00Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
9.52Single5DHHSB-6121115DHH-NOP-SB-612111
9.52Single6KUXRS-799486KUX-α2a-RS-79948
9.52Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
9.52Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
9.52Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
9.52Single7BR3Elagolix7BR3-GnRH1-Elagolix
9.52Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
9.52Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
9.52Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
9.52Single8FN0Neurotensin/neuromedin N8FN0-NTS1-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
9.52Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
9.52Consensus5ht2c_onOrthosteric Ligand8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.52Consensusalpha2a_offOrthosteric Ligand6KUX-α2a-RS-79948
9.52Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
9.38Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
9.30Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
9.09Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
9.09Single6IQLL7458706IQL-D4-L745870
9.09Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
9.09Single7SK3CXCL127SK3-ACKR3-CXCL12
9.09Single7XJJGalanin7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
9.09Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
9.09Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.09Single8JD6N-(3-chlorophenyl)pyridine-2-carboxamide8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
9.09Single8K2WAMG4878K2W-CXCR3-AMG487
9.09Single8T3VDHA8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.09Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
9.09Consensusgnrh_offOrthosteric Ligandgnrh1_off
9.09Consensusgo_galaninOrthosteric Ligand7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
9.09Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
9.09Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
9.09Consensuss1p_offOrthosteric Ligands1p1_off
8.82Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
8.82Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
8.70Single2Y01Dobutamine2Y01-β1-Dobutamine
8.70Single4YAYZD-71554YAY-AT1-ZD-7155
8.70Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
8.70Single5DHGPubChem 250014125DHG-NOP-PubChem 25001412
8.70Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
8.70Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
8.70Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
8.70Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
8.70Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
8.70Consensus5ht1a_onOrthosteric Ligand8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
8.70Consensuscck_offOrthosteric Ligandccka_off
8.70Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
8.70Consensusffa1_onOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.70Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
8.70Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
8.70Consensushcar_offOrthosteric Ligandsuccinate_off
8.70Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
8.57Consensuscalcitonin_onOrthosteric Ligandct_on ctlike_on
8.57Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
8.33Single2Y00Dobutamine2Y00-β1-Dobutamine
8.33Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
8.33Single5WIUNemonapride5WIU-D4-Nemonapride
8.33Single5WIVNemonapride5WIV-D4-Nemonapride-Na
8.33Single6Z4SSR486926Z4S-NTS1-SR48692
8.33Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
8.33Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
8.33Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
8.33Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
8.33Single8JPCNeurotensin 8-138JPC-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
8.33Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
8.33Consensusccr2_off_alloOther Ligand5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
8.33Consensusd4_offOrthosteric Ligand5WIU-D4-Nemonapride
8.33Consensusd4_off_alloOrthosteric Ligand5WIV-D4-Nemonapride-Na
8.00Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
8.00Single4BV0Neurotensin4BV0-NTS1-Neurotensin
8.00Single6OS1TRV0266OS1-AT1-TRV026
8.00Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
8.00Single7F1TMIP-1a7F1T-CCR5-MIP-1a
8.00Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1
8.00Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/&β;1/&γ;1
8.00Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
8.00Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.69Single4GRVNeurotensin 8-134GRV-NTS1-Neurotensin 8-13
7.69Single4PY02MeSATP4PY0-P2Y12-2MeSATP
7.69Single4XEENeurotensin4XEE-NTS1-Neurotensin
7.69Single4XESNeurotensin4XES-NTS1-Neurotensin
7.69Single5X33BIIL2605X33-BLT1-BIIL260
7.69Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.69Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.69Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/&β;1/&γ;2
7.69Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
7.69Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
7.69Consensusnts1_offOrthosteric Ligand6Z4Q-NTS1-SR142948A 6Z4S-NTS1-SR48692
7.69Consensusnts_offOrthosteric Ligandnts1_off
7.41Single4BUONeurotensin4BUO-NTS1-Neurotensin
7.41Single7CX2PGE27CX2-EP2-PGE2-Gs/&β;1/&γ;2
7.41Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
7.41Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.41Consensusgs_galaninOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.14Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
7.14Consensusclass-c_offOther Ligandgabab_off mglu_off
6.98Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
6.90Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
6.90Consensusnmur1_onOrthosteric Ligand7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.82Consensusgs_ctOrthosteric Ligand7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
6.67Single7SHEPI; PE7SHE-GPR158-PI; PE
6.67Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
6.67Single7SK5CXCL127SK5-ACKR3-CXCL12
6.67Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.67Consensussst_offOrthosteric Ligandsst2_off
6.45Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
6.25Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
5.88Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
5.88Consensusccr8_offOrthosteric Ligand8TLM-CCR8-Anti-murine CCR8 antibody
5.56Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
5.56Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/&β;1/&γ;2
5.41Single7TYIAmylin7TYI-CT-Amylin-Gs/&β;1/&γ;2
5.41Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
5.26Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
5.26Single7Y14Beta-alanine7Y14-MRGPRD-Beta-alanine
5.26Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/&β;1/&γ;2
5.00Single4XNWMRS25004XNW-P2Y1-MRS2500
5.00Single6FUFAll-trans-retinal6FUF-Rhodopsin-All-trans-retinal-Go/&β;1/&γ;2
5.00Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
5.00Single7Y12Beta-alanine7Y12-MRGPRD-Beta-alanine-Gi1/&β;1/&γ;2
5.00Single8F76-8F76-OR51E2-Gs/&β;1/&γ;2
5.00Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/&β;1/&γ;2
5.00Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
5.00Consensusgip_on_alloOther Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
5.00Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
4.76Single4O9RCyclopamine4O9R-SMO-Cyclopamine
4.76Single7UL2SR486927UL2-NTS1-SR48692-Na
4.76Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
4.76Single8J6QCompound 9n8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
4.76Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
4.76Single8X2K5YM8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
4.76Consensusclass-t_onOrthosteric Ligandtaste2_on
4.76Consensusgo_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
4.76Consensusgo_proteinOrthosteric Ligandgo_chemokine
4.76Consensusgs_class-tOrthosteric Ligandgs_taste
4.76Consensusgs_tasteOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
4.76Consensushca2_on_alloOther Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
4.76Consensusnts1_off_alloOrthosteric Ligand7UL2-NTS1-SR48692-Na
4.76Consensustaste2_onOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
4.55Single4BWBNeurotensin4BWB-NTS1-Neurotensin
4.55Single4K5YCP-3763954K5Y-CRF1-CP-376395
4.55Single4QINSAG1.54QIN-SMO-SAG1.5
4.55Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
4.55Single6WWZCCL206WWZ-CCR6-CCL20-Go/&β;1/&γ;2
4.55Single7F8YDevazepide7F8Y-CCKA-Devazepide
4.55Single7W0OElabela7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
4.55Single8DWHCompound-168DWH-MRGPRX1-Compound-16-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.55Single8HNNSCH5467388HNN-CXCR3-SCH546738
4.55Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
4.55Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2
4.55Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
4.35Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
4.35Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
4.35Single6ZINSR486926ZIN-NTS1-SR48692
4.35Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
4.35Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
4.35Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.35Consensusgi_class-fOrthosteric Ligandgi_frizzled
4.35Consensusgi_frizzledOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
4.17Single4Z9GCP-3763954Z9G-CRF1-CP-376395
4.17Single5T04Neurotensin5T04-NTS1-Neurotensin
4.17Single6GPSMK08126GPS-CCR2-MK0812
4.17Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
4.17Single8GTIBMK-C2058GTI-CRF1-BMK-C205
4.17Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/&β;1/&γ;2
4.00Single6GPXMK08126GPX-CCR2-MK0812
4.00Single8GTGBMK-I1528GTG-CRF1-BMK-I152
3.85Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.70Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
3.70Single6YVRNTS8-136YVR-NTS1-NTS8-13
3.70Single7SHEPI; PE7SHE-GPR158-PI; PE
3.70Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.70Single8GTMBMK-C2038GTM-CRF1-BMK-C203
3.70Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.57Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
3.45Single8INRAlpha-MSH8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
3.33Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
3.33Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
3.23Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
2.63Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
2.63Single7TYLAmylin7TYL-CT-Amylin-Gs/&β;1/&γ;2
2.63Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/&β;1/&γ;2; RAMP2
2.56Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
2.50Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
2.50Single8F0KPramlintide analogue san3858F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.33Single8F2APramlintide analogue san3858F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.17Single8F2BPramlintide analogue san458F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
2.08Single8F0JPramlintide analogue san458F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2

Consensus Members
Id Members
adgrg_on adgrg2_on
adgrg3_on
Net Summary
Imin 3.9475
Number of Linked Nodes 262
Number of Links 277
Number of Hubs 32
Number of Links mediated by Hubs 146
Number of Communities 3
Number of Nodes involved in Communities 26
Number of Links involved in Communities 33
Path Summary
Number Of Nodes in MetaPath 56
Number Of Links MetaPath 55
Number of Shortest Paths 29254
Length Of Smallest Path 3
Average Path Length 15.8565
Length of Longest Path 39
Minimum Path Strength 0.385
Average Path Strength 5.39171
Maximum Path Strength 12.3567
Minimum Path Correlation 0.7
Average Path Correlation 0.886031
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 2.85714
Average % Of Corr. Nodes 28.5417
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 41.0299
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .




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