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Show: Click this button to access the corresponding database entry page.
PDB: PDB code of the receptor used to compute the network and a direct link to the corresponding entry in the Protein Data Bank.
Class: Receptor Class.
SubFamily: Receptor Sub Family.
Type: Receptor Type.
Subtype: Receptor SubType.
Species: Organism.
Orthosteric Ligand: Name of the orthosteric ligand, if present.
Other Ligand(s): Name of other allosteric ligands, if present.
Protein Partners: G Protein, Arrestin or Kinase coupled to a given receptor.
Resolution: Structure resolution.
Date: Deposition date.
DOI: DOI and link of the corresponding paper.
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
---|---|---|---|---|---|---|---|---|---|---|---|---|
7E2X | A | Amine | 5-Hydroxytryptamine | 5-HT1A | Homo sapiens | - | - | Gi1/&β;1/&γ;2 | 3 | 2021-04-14 | 10.1038/s41586-021-03376-8 | |
7E2Y | A | Amine | 5-Hydroxytryptamine | 5-HT1A | Homo sapiens | Serotonin | - | Gi1/&β;1/&γ;2 | 3 | 2021-04-14 | 10.1038/s41586-021-03376-8 | |
7E2Z | A | Amine | 5-Hydroxytryptamine | 5-HT1A | Homo sapiens | Aripiprazole | - | Gi1/&β;1/&γ;2 | 3.1 | 2021-04-14 | 10.1038/s41586-021-03376-8 | |
8JSP | A | Amine | 5-Hydroxytryptamine | 5-HT1A | Homo sapiens | Ulotaront | - | Gi1/&β;1/&γ;2 | 3.65 | 2023-11-15 | 10.1038/s41586-023-06804-z | |
8JT6 | A | Amine | 5-Hydroxytryptamine | 5-HT1A | Homo sapiens | (R)-IHCH-7179 | - | Gi1/&β;1/&γ;2 | 3 | 2024-02-28 | To be published | |
8W8B | A | Amine | 5-Hydroxytryptamine | 5-HT1A | Homo sapiens | SEP-363856 | - | Gi1/&β;1/&γ;2 | 3 | 2023-11-22 | 10.1038/s41586-023-06775-1 | |
6G79 | A | Amine | 5-Hydroxytryptamine | 5-HT1B | Homo sapiens | Donitriptan | - | Go/&β;1/&γ;2 | 3.78 | 2018-06-20 | 10.1038/s41586-018-0241-9 | |
7E32 | A | Amine | 5-Hydroxytryptamine | 5-HT1D | Homo sapiens | Serotonin | - | Gi1/&β;1/&γ;2 | 2.9 | 2021-04-21 | 10.1038/s41586-021-03376-8 | |
7E33 | A | Amine | 5-Hydroxytryptamine | 5-HT1E | Homo sapiens | BRL-54443 | - | Gi1/&β;1/&γ;2 | 2.9 | 2021-04-14 | 10.1038/s41586-021-03376-8 | |
7EXD | A | Amine | 5-Hydroxytryptamine | 5-HT1F | Homo sapiens | Lasmiditan | - | Gi1/&β;1/&γ;2 | 3.4 | 2021-08-04 | 10.1038/s41422-021-00527-4 | |
6WHA | A | Amine | 5-Hydroxytryptamine | 5-HT2A | Homo sapiens | DB13948 | - | chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 | 3.36 | 2020-09-23 | 10.1016/j.cell.2020.08.024 | |
7RAN | A | Amine | 5-Hydroxytryptamine | 5-HT2A | Homo sapiens | PubChem 164575847 | - | chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 | 3.45 | 2022-07-06 | 10.1038/s41586-022-05258-z | |
7SRR | A | Amine | 5-Hydroxytryptamine | 5-HT2B | Homo sapiens | LSD | - | chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 | 2.9 | 2022-09-21 | 10.1016/j.neuron.2022.08.006 | |
8DPF | A | Amine | 5-Hydroxytryptamine | 5-HT2C | Homo sapiens | Lorcaserin | - | chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 | 2.84 | 2022-08-24 | 10.1016/j.celrep.2022.111211 | |
8DPG | A | Amine | 5-Hydroxytryptamine | 5-HT2C | Homo sapiens | Psilocin | - | chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 | 3.6 | 2022-08-24 | 10.1016/j.celrep.2022.111211 | |
8DPH | A | Amine | 5-Hydroxytryptamine | 5-HT2C | Homo sapiens | Lorcaserin | - | chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 | 3.2 | 2022-08-24 | 10.1016/j.celrep.2022.111211 | |
8DPI | A | Amine | 5-Hydroxytryptamine | 5-HT2C | Homo sapiens | Lorcaserin | - | chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 | 3.4 | 2022-08-24 | 10.1016/j.celrep.2022.111211 | |
7XT8 | A | Amine | 5-Hydroxytryptamine | 5-HT4 | Homo sapiens | Serotonin | - | Gs/&β;1/&γ;2 | 3.1 | 2022-07-27 | 10.1016/j.molcel.2022.05.031 | |
7XT9 | A | Amine | 5-Hydroxytryptamine | 5-HT4 | Homo sapiens | Serotonin | - | Gs/&β;1/&γ;2 | 3.2 | 2022-07-27 | 10.1016/j.molcel.2022.05.031 | |
7XTA | A | Amine | 5-Hydroxytryptamine | 5-HT4 | Homo sapiens | Serotonin | - | Gi1/&β;1/&γ;2 | 3.2 | 2022-07-27 | 10.1016/j.molcel.2022.05.031 | |
7UM5 | A | Amine | 5-Hydroxytryptamine | 5-HT5A | Homo sapiens | 5-CT | - | chim(NtGi1-Go)/&β;1/&γ;2 | 2.73 | 2022-07-20 | 10.1038/s41594-022-00796-6 | |
7UM6 | A | Amine | 5-Hydroxytryptamine | 5-HT5A | Homo sapiens | Lisuride | - | chim(NtGi1-Go)/&β;1/&γ;2 | 2.79 | 2022-07-20 | 10.1038/s41594-022-00796-6 | |
7UM7 | A | Amine | 5-Hydroxytryptamine | 5-HT5A | Homo sapiens | Methylergometrine | - | chim(NtGi1-Go)/&β;1/&γ;2 | 2.75 | 2022-07-20 | 10.1038/s41594-022-00796-6 | |
7X5H | A | Amine | 5-Hydroxytryptamine | 5-HT5A | Homo sapiens | 5-CT | - | Gi1/&β;1/&γ;2 | 3.1 | 2022-09-14 | 10.1038/s41421-022-00412-3 | |
7XTB | A | Amine | 5-Hydroxytryptamine | 5-HT6 | Homo sapiens | Serotonin | - | Gs/&β;1/&γ;2 | 3.3 | 2022-07-27 | 10.1016/j.molcel.2022.05.031 | |
7YS6 | A | Amine | 5-Hydroxytryptamine | 5-HT6 | Homo sapiens | Serotonin | - | chim(NtGi1-Gs)/&β;1/&γ;2 | 3 | 2023-03-29 | 10.1073/pnas.2209917120 | |
8JLZ | A | Amine | 5-Hydroxytryptamine | 5-HT6 | Homo sapiens | ST1936 | - | Gs/&β;1/&γ;2 | 3.09 | 2023-06-28 | 10.1016/j.bbrc.2023.05.126 | |
7XTC | A | Amine | 5-Hydroxytryptamine | 5-HT7 | Homo sapiens | 5-CT | - | Gs/&β;1/&γ;2 | 3.2 | 2022-07-27 | 10.1016/j.molcel.2022.05.031 | |
6D9H | A | Nucleotide | Adenosine | A1 | Homo sapiens | Adenosine | - | Gi2/&β;1/&γ;2 | 3.6 | 2018-06-20 | 10.1038/s41586-018-0236-6 | |
7LD3 | A | Nucleotide | Adenosine | A1 | Homo sapiens | Adenosine | PubChem 25263603 | Gi2/&β;1/&γ;2 | 3.2 | 2021-09-08 | 10.1038/s41586-021-03897-2 | |
7LD4 | A | Nucleotide | Adenosine | A1 | Homo sapiens | Adenosine | - | Gi2/&β;1/&γ;2 | 3.3 | 2021-09-08 | 10.1038/s41586-021-03897-2 | |
5G53 | A | Nucleotide | Adenosine | A2A | Homo sapiens | NECA | - | Gs | 3.4 | 2016-08-03 | 10.1038/nature18966 | |
6GDG | A | Nucleotide | Adenosine | A2A | Homo sapiens | NECA | - | Gs/&β;1/&γ;1 | 4.11 | 2018-05-16 | 10.7554/eLife.35946 | |
7XY6 | A | Nucleotide | Adenosine | A2B | Homo sapiens | PubChem 11717831 | - | chim(NtGi1-Gs)/&β;1/&γ;2 | 2.99 | 2023-05-03 | 10.1126/sciadv.add3709 | |
7XY7 | A | Nucleotide | Adenosine | A2B | Homo sapiens | NECA | - | chim(NtGi1-Gs)/&β;1/&γ;2 | 3.26 | 2023-05-03 | 10.1126/sciadv.add3709 | |
8HDO | A | Nucleotide | Adenosine | A2B | Homo sapiens | BAY 60-6583 | - | Gs/&β;1/&γ;2 | 2.87 | 2023-01-18 | 10.1038/s41421-022-00503-1 | |
8HDP | A | Nucleotide | Adenosine | A2B | Homo sapiens | Adenosine | - | Gs/&β;1/&γ;2 | 3.2 | 2023-01-18 | 10.1038/s41421-022-00503-1 | |
8X16 | A | Nucleotide | Adenosine | A3A | Homo sapiens | Piclidenoson | - | Gi1/&β;1/&γ;2 | 3.29 | 2024-04-24 | 10.1038/s41467-024-47207-6 | |
8X17 | A | Nucleotide | Adenosine | A3A | Homo sapiens | Namodenoson | - | Gi1/&β;1/&γ;2 | 3.19 | 2024-04-24 | 10.1038/s41467-024-47207-6 | |
7EPT | B2 | Adhesion | Adhesion | ADGRD1 | Homo sapiens | - | - | Gs/&β;1/&γ;2 | 3 | 2022-05-11 | 10.1038/s41586-022-04619-y | |
7WU2 | B2 | Adhesion | Adhesion | ADGRD1 | Homo sapiens | - | - | Gs/&β;1/&γ;1 | 2.8 | 2022-04-27 | 10.1038/s41586-022-04580-w | |
7YDH | B2 | Adhesion | Adhesion | ADGRE5 | Homo sapiens | - | - | chim(NtGi2-G13)/&β;1/&γ;2 | 3.1 | 2023-07-12 | 10.1016/j.chembiol.2023.08.003 | |
7YDJ | B2 | Adhesion | Adhesion | ADGRE5 | Homo sapiens | - | - | chim(NtGi1-G12)/&β;1/&γ;2 | 3.03 | 2023-07-12 | To be published | |
7YDM | B2 | Adhesion | Adhesion | ADGRE5 | Homo sapiens | - | - | chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 | 2.89 | 2023-07-12 | 10.1016/j.chembiol.2023.08.003 | |
7YDP | B2 | Adhesion | Adhesion | ADGRE5 | Homo sapiens | - | - | chim(NtGi1-Gs)/&β;1/&γ;2 | 3.1 | 2023-07-12 | 10.1016/j.chembiol.2023.08.003 | |
8IKL | B2 | Adhesion | Adhesion | ADGRE5 | Homo sapiens | - | - | chim(NtGi1L-G13)/&β;1/&γ;2 | 2.33 | 2024-01-24 | 10.1016/j.molcel.2023.12.020 | |
7WU3 | B2 | Adhesion | Adhesion | ADGRF1 | Homo sapiens | - | K6G | Gs/&β;1/&γ;2 | 3.1 | 2022-04-27 | 10.1038/s41586-022-04580-w | |
7WU4 | B2 | Adhesion | Adhesion | ADGRF1 | Homo sapiens | - | K6G | Gi1/&β;1/&γ;2 | 3.4 | 2022-04-27 | 10.1038/s41586-022-04580-w | |
7WU5 | B2 | Adhesion | Adhesion | ADGRF1 | Homo sapiens | - | K6G | Gi1/&β;1/&γ;2 | 3 | 2022-04-27 | 10.1038/s41586-022-04580-w | |
7WXU | B2 | Adhesion | Adhesion | ADGRF1 | Homo sapiens | - | - | chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 | 2.85 | 2022-09-28 | 10.1038/s41467-022-33173-4 | |
7WXW | B2 | Adhesion | Adhesion | ADGRF1 | Homo sapiens | - | - | chim(NtGi1-Gs)/&β;1/&γ;2 | 2.84 | 2022-09-28 | 10.1038/s41467-022-33173-4 | |
7WY0 | B2 | Adhesion | Adhesion | ADGRF1 | Homo sapiens | - | - | chim(NtGi1L-G13)/&β;1/&γ;2 | 2.83 | 2022-09-28 | 10.1038/s41467-022-33173-4 | |
7WZ7 | B2 | Adhesion | Adhesion | ADGRF1 | Homo sapiens | - | - | chim(NtGi1-G12)/&β;1/&γ;2 | 2.83 | 2022-09-28 | 10.1038/s41467-022-33173-4 | |
7X2V | B2 | Adhesion | Adhesion | ADGRF1 | Homo sapiens | - | - | Gi1/&β;1/&γ;2 | 3.09 | 2022-09-28 | 10.1038/s41467-022-33173-4 | |
8G2Y | B2 | Adhesion | Adhesion | ADGRF1 | Homo sapiens | - | LPC | chim(Gs-CtGq)/&β;1/&γ;2 | 3.44 | 2023-05-10 | 10.1038/s41467-023-38083-7 | |
7SF8 | B2 | Adhesion | Adhesion | ADGRG1 | Homo sapiens | - | - | chim(NtGi2-G13)/&β;1/&γ;2 | 2.7 | 2022-04-27 | 10.1038/s41586-022-04575-7 | |
7WUI | B2 | Adhesion | Adhesion | ADGRG2 | Mus musculus | IP15 | - | chim(NtGi1-Gs)/&β;1/&γ;2 | 3.1 | 2022-04-27 | 10.1038/s41586-022-04590-8 | |
7WUQ | B2 | Adhesion | Adhesion | ADGRG2 | Mus musculus | - | - | Gs/&β;1/&γ;2 | 2.9 | 2022-04-27 | 10.1038/s41586-022-04590-8 | |
7XKD | B2 | Adhesion | Adhesion | ADGRG2 | Mus musculus | Betahydroxyandrosterone | - | Gs/&β;1/&γ;2 | 2.4 | 2022-08-10 | 10.1038/s41589-022-01084-6 | |
7XKE | B2 | Adhesion | Adhesion | ADGRG2 | Mus musculus | Betahydroxyandrosterone | - | chim(NtGi1-Gs)/&β;1/&γ;2 | 2.9 | 2022-08-10 | 10.1038/s41589-022-01084-6 | |
7XKF | B2 | Adhesion | Adhesion | ADGRG2 | Mus musculus | Betahydroxyandrosterone | - | Gs/&β;1/&γ;2 | 2.4 | 2022-08-10 | 10.1038/s41589-022-01084-6 | |
7YP7 | B2 | Adhesion | Adhesion | ADGRG2 | Mus musculus | - | - | Gs/&β;1/&γ;2 | 3.1 | 2022-08-24 | 10.1038/s41589-022-01084-6 | |
7D76 | B2 | Adhesion | Adhesion | ADGRG3 | Homo sapiens | Beclomethasone | - | Go/&β;1/&γ;2 | 3.1 | 2021-02-03 | 10.1038/s41586-020-03083-w | |
7D77 | B2 | Adhesion | Adhesion | ADGRG3 | Homo sapiens | Hydrocortisone | - | Go/&β;1/&γ;2 | 2.9 | 2021-02-03 | 10.1038/s41586-020-03083-w | |
7WUJ | B2 | Adhesion | Adhesion | ADGRG4 | Homo sapiens | - | - | chim(NtGi1-Gs)/&β;1/&γ;2 | 3.3 | 2022-04-27 | 10.1038/s41586-022-04590-8 | |
7EQ1 | B2 | Adhesion | Adhesion | ADGRG5 | Homo sapiens | - | - | chim(NtGi1-Gs)/&β;1/&γ;2 | 3.3 | 2022-05-11 | 10.1038/s41586-022-04619-y | |
7SF7 | B2 | Adhesion | Adhesion | ADGRL3 | Homo sapiens | - | - | chim(NtGi2-G13)/&β;1/&γ;2 | 2.9 | 2022-04-27 | 10.1038/s41586-022-04575-7 | |
7WY5 | B2 | Adhesion | Adhesion | ADGRL3 | Mus musculus | - | - | chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 | 2.83 | 2022-10-26 | 10.1016/j.molcel.2022.10.009 | |
7WY8 | B2 | Adhesion | Adhesion | ADGRL3 | Mus musculus | - | - | chim(NtGi1-Gs)/&β;1/&γ;2 | 2.83 | 2022-10-26 | 10.1016/j.molcel.2022.10.009 | |
7WYB | B2 | Adhesion | Adhesion | ADGRL3 | Mus musculus | - | - | Gi1/&β;1/&γ;2 | 2.97 | 2022-10-26 | 10.1016/j.molcel.2022.10.009 | |
7X10 | B2 | Adhesion | Adhesion | ADGRL3 | Mus musculus | - | - | chim(NtGi1-G12)/&β;1/&γ;2 | 2.93 | 2022-10-26 | 10.1016/j.molcel.2022.10.009 | |
7YM8 | A | Amine | Adrenergic | Alpha1A | Homo sapiens | Oxymetazoline | - | chim(Gs-CtGq)/&β;1/&γ;2 | 2.92 | 2023-07-05 | 10.1038/s41467-023-39310-x | |
7YMH | A | Amine | Adrenergic | Alpha1A | Homo sapiens | Norepinephrine | - | chim(Gs-CtGq)/&β;1/&γ;2 | 3.52 | 2023-07-05 | 10.1038/s41467-023-39310-x | |
8THK | A | Amine | Adrenergic | Alpha1A | Homo sapiens | A61603 | - | chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 | 2.6 | 2023-08-16 | 10.1038/s41467-023-40524-2 | |
8THL | A | Amine | Adrenergic | Alpha1A | Homo sapiens | Epinephrine | - | chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 | 3.1 | 2023-08-16 | 10.1038/s41467-023-40524-2 | |
7EJ0 | A | Amine | Adrenergic | α2a | Homo sapiens | L-Norepinephrine | - | Go/&β;1/&γ;2 | 3.2 | 2022-04-13 | 10.1126/sciadv.abj5347 | |
7EJ8 | A | Amine | Adrenergic | α2a | Homo sapiens | Brimonidine | - | Go/&β;1/&γ;2 | 3 | 2022-04-13 | 10.1126/sciadv.abj5347 | |
7EJA | A | Amine | Adrenergic | α2a | Homo sapiens | Dexmedetomidine | - | Go/&β;1/&γ;2 | 3.6 | 2022-04-13 | 10.1126/sciadv.abj5347 | |
7EJK | A | Amine | Adrenergic | α2a | Homo sapiens | Oxymetazoline | - | Go/&β;1/&γ;2 | 3.4 | 2022-04-13 | 10.1126/sciadv.abj5347 | |
7W6P | A | Amine | Adrenergic | α2a | Homo sapiens | W96 | - | Go/&β;1/&γ;2 | 3.47 | 2022-09-28 | 10.1126/science.abn7065 | |
7W7E | A | Amine | Adrenergic | α2a | Homo sapiens | W58 | - | Go/&β;1/&γ;2 | 3.4 | 2022-09-28 | 10.1126/science.abn7065 | |
6K41 | A | Amine | Adrenergic | α2b | Homo sapiens | Dexmedetomidine | - | Go/&β;1/&γ;2 | 2.9 | 2020-04-15 | 10.1038/s41589-020-0492-2 | |
6K42 | A | Amine | Adrenergic | α2b | Homo sapiens | Dexmedetomidine | - | Gi1/&β;1/&γ;2 | 4.1 | 2020-04-15 | 10.1038/s41589-020-0492-2 | |
7W0L | A | Peptide | Apelin | Apelin | Homo sapiens | PubChem 122701908 | - | Gi1/&β;1/&γ;2 | 3.57 | 2022-07-27 | 10.1038/s41594-022-00797-5 | |
7W0M | A | Peptide | Apelin | Apelin | Homo sapiens | PubChem 122701908 | - | Gi1/&β;1/&γ;2 | 3.71 | 2022-07-27 | 10.1038/s41594-022-00797-5 | |
7W0N | A | Peptide | Apelin | Apelin | Homo sapiens | Elabela | - | Gi1/&β;1/&γ;2 | 4.21 | 2022-07-27 | 10.1038/s41594-022-00797-5 | |
7W0O | A | Peptide | Apelin | Apelin | Homo sapiens | Elabela | - | Gi1/&β;1/&γ;2 | 3.78 | 2022-07-27 | 10.1038/s41594-022-00797-5 | |
7W0P | A | Peptide | Apelin | Apelin | Homo sapiens | Elabela | - | Gi1/&β;1/&γ;2 | 3.16 | 2022-07-27 | 10.1038/s41594-022-00797-5 | |
8XZF | A | Peptide | Apelin | Apelin | Homo sapiens | WN561 | - | Gi1/&β;1/&γ;2 | 3 | 2024-03-20 | 10.1016/j.cell.2024.02.004 | |
8XZG | A | Peptide | Apelin | Apelin | Homo sapiens | Apelin-13 | - | Gi1/&β;1/&γ;2 | 3.2 | 2024-03-20 | 10.1016/j.cell.2024.02.004 | |
8XZH | A | Peptide | Apelin | Apelin | Homo sapiens | MM07 | - | Gi1/&β;1/&γ;2 | 2.06 | 2024-03-20 | 10.1016/j.cell.2024.02.004 | |
8XZJ | A | Peptide | Apelin | Apelin | Homo sapiens | WN353 | - | Gi1/&β;1/&γ;2 | 3 | 2024-03-20 | 10.1016/j.cell.2024.02.004 | |
7F6G | A | Peptide | Angiotensin | AT1 | Homo sapiens | SAR1-AngII | - | Gq/&β;1/&γ;2 | 2.9 | 2023-03-29 | 10.15252/embj.2022112940 | |
8H0P | A | Peptide | Bombesin | BB1 | Homo sapiens | NMB30 | - | chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 | 3.15 | 2023-08-09 | 10.1038/s41422-022-00743-6 | |
7W3Z | A | Peptide | Bombesin | BB2 | Homo sapiens | Gastrin Releasing Peptide | - | chim(NtGi1L-Gq)/&β;1/&γ;2 | 3 | 2023-02-22 | 10.1073/pnas.2216230120 | |
7W40 | A | Peptide | Bombesin | BB2 | Homo sapiens | Bombesin | - | chim(NtGi1L-Gq)/&β;1/&γ;2 | 3 | 2023-02-22 | 10.1073/pnas.2216230120 | |
8H0Q | A | Peptide | Bombesin | BB2 | Homo sapiens | Gastrin Releasing Peptide | - | chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 | 3.3 | 2023-08-09 | 10.1038/s41422-022-00743-6 | |
7JJO | A | Amine | Adrenergic | β1 | Meleagris gallopavo | Isoprenaline | - | Gs/&β;1/&γ;2 | 2.6 | 2020-09-02 | 10.1016/j.molcel.2020.08.001 | |
7S0F | A | Amine | Adrenergic | β1 | Meleagris gallopavo | Isoprenaline | - | Gi1/&β;1/&γ;2 | 2.96 | 2021-11-17 | 10.1038/s41594-021-00679-2 | |
7S0G | A | Amine | Adrenergic | β1 | Meleagris gallopavo | Isoprenaline | - | chim(Gi1-CtGs)/&β;1/&γ;2 | 3.86 | 2021-11-17 | 10.1038/s41594-021-00679-2 | |
8DCR | A | Amine | Adrenergic | β1 | Meleagris gallopavo | Dobutamine | - | Gs/&β;1/&γ;2 | 2.6 | 2022-07-27 | 10.1038/s41467-022-31823-1 | |
8DCS | A | Amine | Adrenergic | β1 | Meleagris gallopavo | Cyanopindolol | - | Gs/&β;1/&γ;2 | 2.5 | 2022-07-27 | 10.1038/s41467-022-31823-1 | |
3SN6 | A | Amine | Adrenergic | β2 | Homo sapiens | BI167107 | - | Gs/&β;1/&γ;2 | 3.2 | 2011-07-20 | 10.1038/nature10361 | |
6E67 | A | Amine | Adrenergic | β2 | Homo sapiens | BI167107 | - | Gs (fused) | 3.7 | 2019-06-05 | 10.1016/j.cell.2019.04.021 | |
6NI3 | A | Amine | Adrenergic | β2 | Homo sapiens | BI167107 | - | Gs/&β;1/&γ;2 | 3.8 | 2019-11-20 | 10.1038/s41594-019-0330-y | |
7BZ2 | A | Amine | Adrenergic | β2 | Homo sapiens | Arformoterol | - | Gs/&β;1/&γ;2 | 3.82 | 2020-08-05 | 10.1038/s41421-020-0176-9 | |
7DHI | A | Amine | Adrenergic | β2 | Homo sapiens | Salbutamol | - | Gs/&β;1/&γ;2 | 3.26 | 2020-12-16 | 10.1093/nsr/nwaa284 | |
7DHR | A | Amine | Adrenergic | β2 | Homo sapiens | Isoprenaline | - | Gs/&β;1/&γ;2 | 3.8 | 2020-12-16 | 10.1093/nsr/nwaa284 | |
8GDZ | A | Amine | Adrenergic | β2 | Homo sapiens | Epinephrine | - | Gs/&β;1/&γ;2 | 3.5 | 2024-03-06 | 10.1038/s41586-024-07153-1 | |
8GE1 | A | Amine | Adrenergic | β2 | Homo sapiens | Epinephrine | - | Gs/&β;1/&γ;2 | 3.4 | 2024-03-06 | 10.1038/s41586-024-07153-1 | |
8GE3 | A | Amine | Adrenergic | β2 | Homo sapiens | Epinephrine | - | Gs/&β;1/&γ;2 | 3.3 | 2024-03-06 | 10.1038/s41586-024-07153-1 | |
8GE4 | A | Amine | Adrenergic | β2 | Homo sapiens | Epinephrine | - | Gs/&β;1/&γ;2 | 3.3 | 2024-03-06 | 10.1038/s41586-024-07153-1 | |
8GE6 | A | Amine | Adrenergic | β2 | Homo sapiens | Epinephrine | - | Gs/&β;1/&γ;2 | 3.4 | 2024-03-06 | 10.1038/s41586-024-07153-1 | |
8GE7 | A | Amine | Adrenergic | β2 | Homo sapiens | Epinephrine | - | Gs/&β;1/&γ;2 | 3.4 | 2024-03-06 | 10.1038/s41586-024-07153-1 | |
8GE8 | A | Amine | Adrenergic | β2 | Homo sapiens | Epinephrine | - | Gs/&β;1/&γ;2 | 3.4 | 2024-03-06 | 10.1038/s41586-024-07153-1 | |
8GE9 | A | Amine | Adrenergic | β2 | Homo sapiens | Epinephrine | - | Gs/&β;1/&γ;2 | 3.5 | 2024-03-06 | 10.1038/s41586-024-07153-1 | |
8GEA | A | Amine | Adrenergic | β2 | Homo sapiens | Epinephrine | - | Gs/&β;1/&γ;2 | 3.5 | 2024-03-06 | 10.1038/s41586-024-07153-1 | |
8GEB | A | Amine | Adrenergic | β2 | Homo sapiens | Epinephrine | - | Gs/&β;1/&γ;2 | 3.6 | 2024-03-06 | 10.1038/s41586-024-07153-1 | |
8GEC | A | Amine | Adrenergic | β2 | Homo sapiens | Epinephrine | - | Gs/&β;1/&γ;2 | 3.5 | 2024-03-06 | 10.1038/s41586-024-07153-1 | |
8GED | A | Amine | Adrenergic | β2 | Homo sapiens | Epinephrine | - | Gs/&β;1/&γ;2 | 3.5 | 2024-03-06 | 10.1038/s41586-024-07153-1 | |
8GEE | A | Amine | Adrenergic | β2 | Homo sapiens | Epinephrine | - | Gs/&β;1/&γ;2 | 3.7 | 2024-03-06 | 10.1038/s41586-024-07153-1 | |
8GEF | A | Amine | Adrenergic | β2 | Homo sapiens | Epinephrine | - | Gs/&β;1/&γ;2 | 3.8 | 2024-03-06 | 10.1038/s41586-024-07153-1 | |
8GEG | A | Amine | Adrenergic | β2 | Homo sapiens | Epinephrine | - | Gs/&β;1/&γ;2 | 3.8 | 2024-03-06 | 10.1038/s41586-024-07153-1 | |
8GEH | A | Amine | Adrenergic | β2 | Homo sapiens | Epinephrine | - | Gs/&β;1/&γ;2 | 4 | 2024-03-06 | 10.1038/s41586-024-07153-1 | |
8GEI | A | Amine | Adrenergic | β2 | Homo sapiens | Epinephrine | - | Gs/&β;1/&γ;2 | 4.1 | 2024-03-06 | 10.1038/s41586-024-07153-1 | |
8GEJ | A | Amine | Adrenergic | β2 | Homo sapiens | Epinephrine | - | Gs/&β;1/&γ;2 | 4.2 | 2024-03-06 | 10.1038/s41586-024-07153-1 | |
8GFV | A | Amine | Adrenergic | β2 | Homo sapiens | Epinephrine | GTP | Gs/&β;1/&γ;2 | 3.1 | 2024-03-06 | 10.1038/s41586-024-07153-1 | |
8GFW | A | Amine | Adrenergic | β2 | Homo sapiens | Epinephrine | GTP | Gs/&β;1/&γ;2 | 3 | 2024-03-06 | 10.1038/s41586-024-07153-1 | |
8GFX | A | Amine | Adrenergic | β2 | Homo sapiens | Epinephrine | GTP | Gs/&β;1/&γ;2 | 3 | 2024-03-06 | 10.1038/s41586-024-07153-1 | |
8GFY | A | Amine | Adrenergic | β2 | Homo sapiens | Epinephrine | GTP | Gs/&β;1/&γ;2 | 3 | 2024-03-06 | 10.1038/s41586-024-07153-1 | |
8GFZ | A | Amine | Adrenergic | β2 | Homo sapiens | Epinephrine | GTP | Gs/&β;1/&γ;2 | 3 | 2024-03-06 | 10.1038/s41586-024-07153-1 | |
8GG0 | A | Amine | Adrenergic | β2 | Homo sapiens | Epinephrine | GTP | Gs/&β;1/&γ;2 | 2.9 | 2024-03-06 | 10.1038/s41586-024-07153-1 | |
8GG1 | A | Amine | Adrenergic | β2 | Homo sapiens | Epinephrine | GTP | Gs/&β;1/&γ;2 | 3 | 2024-03-06 | 10.1038/s41586-024-07153-1 | |
8GG2 | A | Amine | Adrenergic | β2 | Homo sapiens | Epinephrine | GTP | Gs/&β;1/&γ;2 | 3 | 2024-03-06 | 10.1038/s41586-024-07153-1 | |
8GG3 | A | Amine | Adrenergic | β2 | Homo sapiens | Epinephrine | GTP | Gs/&β;1/&γ;2 | 3.1 | 2024-03-06 | 10.1038/s41586-024-07153-1 | |
8GG4 | A | Amine | Adrenergic | β2 | Homo sapiens | Epinephrine | GTP | Gs/&β;1/&γ;2 | 3.2 | 2024-03-06 | 10.1038/s41586-024-07153-1 | |
8GG5 | A | Amine | Adrenergic | β2 | Homo sapiens | Epinephrine | GTP | Gs/&β;1/&γ;2 | 3.2 | 2024-03-06 | 10.1038/s41586-024-07153-1 | |
8GG6 | A | Amine | Adrenergic | β2 | Homo sapiens | Epinephrine | GTP | Gs/&β;1/&γ;2 | 3.3 | 2024-03-06 | 10.1038/s41586-024-07153-1 | |
8GG7 | A | Amine | Adrenergic | β2 | Homo sapiens | Epinephrine | GTP | Gs/&β;1/&γ;2 | 3.3 | 2024-03-06 | 10.1038/s41586-024-07153-1 | |
8GG8 | A | Amine | Adrenergic | β2 | Homo sapiens | Epinephrine | GTP | Gs/&β;1/&γ;2 | 3.3 | 2024-03-06 | 10.1038/s41586-024-07153-1 | |
8GG9 | A | Amine | Adrenergic | β2 | Homo sapiens | Epinephrine | GTP | Gs/&β;1/&γ;2 | 3.4 | 2024-03-06 | 10.1038/s41586-024-07153-1 | |
8GGA | A | Amine | Adrenergic | β2 | Homo sapiens | Epinephrine | GTP | Gs/&β;1/&γ;2 | 3.5 | 2024-03-06 | 10.1038/s41586-024-07153-1 | |
8GGB | A | Amine | Adrenergic | β2 | Homo sapiens | Epinephrine | GTP | Gs/&β;1/&γ;2 | 3.5 | 2024-03-06 | 10.1038/s41586-024-07153-1 | |
8GGC | A | Amine | Adrenergic | β2 | Homo sapiens | Epinephrine | GTP | Gs/&β;1/&γ;2 | 3.4 | 2024-03-06 | 10.1038/s41586-024-07153-1 | |
8GGE | A | Amine | Adrenergic | β2 | Homo sapiens | Epinephrine | GTP | Gs/&β;1/&γ;2 | 3.5 | 2024-03-06 | 10.1038/s41586-024-07153-1 | |
8GGF | A | Amine | Adrenergic | β2 | Homo sapiens | Epinephrine | GTP | Gs/&β;1/&γ;2 | 3.6 | 2024-03-06 | 10.1038/s41586-024-07153-1 | |
8UNL | A | Amine | Adrenergic | β2 | Homo sapiens | Epinephrine | GTP | Gs/&β;1/&γ;2 | 3.3 | 2024-03-06 | 10.1038/s41586-024-07153-1 | |
8UNM | A | Amine | Adrenergic | β2 | Homo sapiens | Epinephrine | GTP | Gs/&β;1/&γ;2 | 3.4 | 2024-03-06 | 10.1038/s41586-024-07153-1 | |
8UNN | A | Amine | Adrenergic | β2 | Homo sapiens | Epinephrine | GTP | Gs/&β;1/&γ;2 | 3.4 | 2024-03-06 | 10.1038/s41586-024-07153-1 | |
8UNO | A | Amine | Adrenergic | β2 | Homo sapiens | Epinephrine | GTP | Gs/&β;1/&γ;2 | 3.3 | 2024-03-06 | 10.1038/s41586-024-07153-1 | |
8UNP | A | Amine | Adrenergic | β2 | Homo sapiens | Epinephrine | GTP | Gs/&β;1/&γ;2 | 3.3 | 2024-03-06 | 10.1038/s41586-024-07153-1 | |
8UNQ | A | Amine | Adrenergic | β2 | Homo sapiens | Epinephrine | GTP | Gs/&β;1/&γ;2 | 3.3 | 2024-03-06 | 10.1038/s41586-024-07153-1 | |
8UNR | A | Amine | Adrenergic | β2 | Homo sapiens | Epinephrine | GTP | Gs/&β;1/&γ;2 | 3.4 | 2024-03-06 | 10.1038/s41586-024-07153-1 | |
8UNS | A | Amine | Adrenergic | β2 | Homo sapiens | Epinephrine | GTP | Gs/&β;1/&γ;2 | 3.4 | 2024-03-06 | 10.1038/s41586-024-07153-1 | |
8UNT | A | Amine | Adrenergic | β2 | Homo sapiens | Epinephrine | GTP | Gs/&β;1/&γ;2 | 3.4 | 2024-03-06 | 10.1038/s41586-024-07153-1 | |
8UNU | A | Amine | Adrenergic | β2 | Homo sapiens | Epinephrine | GTP | Gs/&β;1/&γ;2 | 3.5 | 2024-03-06 | 10.1038/s41586-024-07153-1 | |
8UNV | A | Amine | Adrenergic | β2 | Homo sapiens | Epinephrine | GTP | Gs/&β;1/&γ;2 | 3.3 | 2024-03-06 | 10.1038/s41586-024-07153-1 | |
8UNW | A | Amine | Adrenergic | β2 | Homo sapiens | Epinephrine | GTP | Gs/&β;1/&γ;2 | 3.4 | 2024-03-06 | 10.1038/s41586-024-07153-1 | |
8UNX | A | Amine | Adrenergic | β2 | Homo sapiens | Epinephrine | GTP | Gs/&β;1/&γ;2 | 3.6 | 2024-03-06 | 10.1038/s41586-024-07153-1 | |
8UNY | A | Amine | Adrenergic | β2 | Homo sapiens | Epinephrine | GTP | Gs/&β;1/&γ;2 | 3.6 | 2024-03-06 | 10.1038/s41586-024-07153-1 | |
8UNZ | A | Amine | Adrenergic | β2 | Homo sapiens | Epinephrine | GTP | Gs/&β;1/&γ;2 | 3.8 | 2024-03-06 | 10.1038/s41586-024-07153-1 | |
8UO0 | A | Amine | Adrenergic | β2 | Homo sapiens | Epinephrine | GTP | Gs/&β;1/&γ;2 | 3.5 | 2024-03-06 | 10.1038/s41586-024-07153-1 | |
8UO1 | A | Amine | Adrenergic | β2 | Homo sapiens | Epinephrine | GTP; Mg | Gs/&β;1/&γ;2 | 3.6 | 2024-03-06 | 10.1038/s41586-024-07153-1 | |
8UO2 | A | Amine | Adrenergic | β2 | Homo sapiens | Epinephrine | GTP | Gs/&β;1/&γ;2 | 3.6 | 2024-03-06 | 10.1038/s41586-024-07153-1 | |
8UO3 | A | Amine | Adrenergic | β2 | Homo sapiens | Epinephrine | GTP; Mg | Gs/&β;1/&γ;2 | 3.5 | 2024-03-06 | 10.1038/s41586-024-07153-1 | |
8UO4 | A | Amine | Adrenergic | β2 | Homo sapiens | Epinephrine | GTP; Mg | Gs/&β;1/&γ;2 | 4 | 2024-03-06 | 10.1038/s41586-024-07153-1 | |
7DH5 | A | Amine | Adrenergic | β3 | Canis lupus familiaris | Mirabegron | - | Gs/&β;1/&γ;2 | 3.16 | 2021-08-04 | 10.1016/j.molcel.2021.06.024 | |
7XJH | A | Amine | Adrenergic | β3 | Canis lupus familiaris | Isoproterenol | - | Gs/&β;1/&γ;2 | 3.3 | 2022-05-04 | 10.1016/j.molcel.2021.06.024 | |
7XJI | A | Amine | Adrenergic | β3 | Canis lupus familiaris | Solabegron | - | Gs/&β;1/&γ;2 | 3.9 | 2022-05-04 | 10.1016/j.bbrc.2022.04.065 | |
7JHJ | A | Other | Unclassified | BILF1 | Human gammaherpesvirus 4 | - | - | Gi1/&β;1/&γ;2 | 3.2 | 2021-07-07 | 10.1016/j.immuni.2021.06.001 | |
7EIB | A | Peptide | Bradykinin | BK1 | Homo sapiens | Des-Arg10-Kallidin | - | chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 | 3 | 2021-10-13 | 10.1038/s41594-021-00645-y | |
7F2O | A | Peptide | Bradykinin | BK2 | Homo sapiens | Bradykinin | - | chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 | 2.9 | 2021-10-13 | 10.1038/s41594-021-00645-y | |
7F6H | A | Peptide | Bradykinin | BK2 | Homo sapiens | Bradykinin | - | Gq/&β;1/&γ;2 | 2.9 | 2022-01-05 | 10.1038/s41467-022-28399-1 | |
7F6I | A | Peptide | Bradykinin | BK2 | Homo sapiens | Kallidin | - | Gq/&β;1/&γ;2 | 2.8 | 2022-01-05 | 10.1038/s41467-022-28399-1 | |
7VKT | A | Lipid | Leukotriene | BLT1 | Homo sapiens | LTB4 | - | Gi1/&β;1/&γ;2 | 2.9 | 2022-03-09 | 10.1038/s41467-022-28820-9 | |
8HK2 | A | Peptide | Complement peptide | C3aB | Homo sapiens | C3a anaphylatoxin | - | Gi1/&β;1/&γ;2 | 2.9 | 2023-05-10 | 10.1038/s41589-023-01339-w | |
8HK3 | A | Peptide | Complement peptide | C3aB | Homo sapiens | - | - | Gi1/&β;1/&γ;2 | 3.2 | 2023-05-10 | 10.1038/s41589-023-01339-w | |
8I95 | A | Peptide | Complement peptide | C3aB | Homo sapiens | EP54 | - | Go/&β;1/&γ;2 | 2.88 | 2023-10-18 | 10.1016/j.cell.2023.09.020 | |
8I97 | A | Peptide | Complement peptide | C3aB | Homo sapiens | - | - | Go/&β;1/&γ;2 | 3.1 | 2023-10-18 | 10.1016/j.cell.2023.09.020 | |
8I9A | A | Peptide | Complement peptide | C3aB | Homo sapiens | EP54 | - | chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 | 3.57 | 2023-10-18 | 10.1016/j.cell.2023.09.020 | |
8I9L | A | Peptide | Complement peptide | C3aB | Homo sapiens | C3a anaphylatoxin | - | Go/&β;1/&γ;2 | 3.18 | 2023-10-18 | 10.1016/j.cell.2023.09.020 | |
8I9S | A | Peptide | Complement peptide | C3aB | Homo sapiens | - | - | Go/&β;1/&γ;2 | 3.26 | 2023-10-18 | 10.1016/j.cell.2023.09.020 | |
8IA8 | A | Peptide | Complement peptide | C3aB | Homo sapiens | E7 peptide | - | Gi1/&β;1/&γ;2 | 2.86 | 2023-05-24 | To be published | |
8J6D | A | Peptide | Complement peptide | C3aB | Homo sapiens | EP141 | - | Go/&β;1/&γ;2 | 3.1 | 2023-10-18 | 10.1016/j.cell.2023.09.020 | |
7Y64 | A | Peptide | Complement peptide | C5a1 | Homo sapiens | C5a anaphylatoxin | - | Gi1/&β;1/&γ;2 | 2.9 | 2023-03-01 | 10.1038/s41422-023-00779-2 | |
7Y65 | A | Peptide | Complement peptide | C5a1 | Homo sapiens | C5a peptide | - | Gi1/&β;1/&γ;2 | 3.2 | 2023-03-01 | 10.1038/s41422-023-00779-2 | |
7Y66 | A | Peptide | Complement peptide | C5a1 | Homo sapiens | BM213 | - | Gi1/&β;1/&γ;2 | 2.9 | 2023-03-01 | 10.1038/s41422-023-00779-2 | |
7Y67 | A | Peptide | Complement peptide | C5a1 | Homo sapiens | C089 peptide | - | Gi1/&β;1/&γ;2 | 2.8 | 2023-03-01 | 10.1038/s41422-023-00779-2 | |
8HK5 | A | Peptide | Complement peptide | C5a1 | Homo sapiens | Complement C5 | - | Gi1/&β;1/&γ;2 | 3 | 2023-05-10 | 10.1038/s41589-023-01339-w | |
8HPT | A | Peptide | Complement peptide | C5a1 | Mus musculus | C5a anaphylatoxin C-terminal peptide | - | Go/&β;1/&γ;2 | 3.39 | 2023-10-18 | 10.1016/j.cell.2023.09.020 | |
8HQC | A | Peptide | Complement peptide | C5a1 | Mus musculus | C5a anaphylatoxin | - | Go/&β;1/&γ;2 | 3.89 | 2023-10-18 | 10.1016/j.cell.2023.09.020 | |
8IA2 | A | Peptide | Complement peptide | C5a1 | Homo sapiens | C5a anaphylatoxin | - | Go/&β;1/&γ;2 | 3.21 | 2023-10-18 | 10.1016/j.cell.2023.09.020 | |
8JZZ | A | Peptide | Complement peptide | C5a1 | Homo sapiens | C5a-desArg | - | Go/&β;1/&γ;2 | 3.31 | 2023-10-18 | 10.1016/j.cell.2023.09.020 | |
8SZG | C | Ion | Calcium-sensing | CaS | Homo sapiens | - | Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW | chim(NtGi1-Gq)/&β;1/&γ;2 | 3.6 | 2024-02-07 | 10.1038/s41586-024-07055-2 | |
8SZH | C | Ion | Calcium-sensing | CaS | Homo sapiens | - | Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW | Gi1/&β;1/&γ;2 | 3.1 | 2024-02-07 | 10.1038/s41586-024-07055-2 | |
8SZI | C | Ion | Calcium-sensing | CaS | Homo sapiens | - | Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW | Gi3/&β;1/&γ;2 | 3.5 | 2024-02-07 | 10.1038/s41586-024-07055-2 | |
8WPU | C | Ion | Calcium-sensing | CaS | Homo sapiens | - | Tryptophan; Cinacalcet; PO4; Ca | chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 | 3.1 | 2023-11-22 | 10.1038/s41422-023-00892-2 | |
9AXF | C | Ion | Calcium-sensing | CaS | Homo sapiens | Ca | Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4 | chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 | 3.5 | 2024-04-17 | 10.1038/s41586-024-07331-1 | |
9AYF | C | Ion | Calcium-sensing | CaS | Homo sapiens | Ca | Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4 | Gi1/&β;1/&γ;2 | 3.6 | 2024-04-17 | 10.1038/s41586-024-07331-1 | |
6KPG | A | Lipid | Cannabinoid | CB1 | Homo sapiens | AM841 | - | Gi1/&β;1/&γ;2 | 3 | 2020-02-12 | 10.1016/j.cell.2020.01.008 | |
6N4B | A | Lipid | Cannabinoid | CB1 | Homo sapiens | MDMB-Fubinaca | - | Gi1/&β;1/&γ;2 | 3 | 2019-01-30 | 10.1016/j.cell.2018.11.040 | |
7WV9 | A | Lipid | Cannabinoid | CB1 | Homo sapiens | PubMed 104895 | ZCZ011 | Gi2/&β;1/&γ;2 | 3.36 | 2022-06-15 | 10.1038/s41589-022-01038-y | |
8GAG | A | Lipid | Cannabinoid | CB1 | Homo sapiens | YVF | - | Gi1/&β;1/&γ;2 | 3.3 | 2024-02-28 | To be published | |
8GHV | A | Lipid | Cannabinoid | CB1 | Homo sapiens | PubChem 145964903 | - | Gi1/&β;1/&γ;2 | 2.8 | 2023-05-24 | 10.1038/s41467-023-37864-4 | |
8K8J | A | Lipid | Cannabinoid | CB1 | Homo sapiens | Fenofibrate | - | chim(Gs-CtGq)/&β;1/&γ;2 | 2.88 | 2024-02-14 | 10.1002/advs.202306311 | |
6KPF | A | Lipid | Cannabinoid | CB2 | Homo sapiens | PubChem 145915889 | - | Gi1/&β;1/&γ;2 | 2.9 | 2020-02-12 | 10.1016/j.cell.2020.01.008 | |
6PT0 | A | Lipid | Cannabinoid | CB2 | Homo sapiens | WIN 55212-2 | - | Gi1/&β;1/&γ;2 | 3.2 | 2020-02-12 | 10.1016/j.cell.2020.01.007 | |
8GUQ | A | Lipid | Cannabinoid | CB2 | Homo sapiens | Olorinab | - | Gi1/&β;1/&γ;2 | 3.08 | 2023-05-10 | 10.1038/s41467-023-37112-9 | |
8GUR | A | Lipid | Cannabinoid | CB2 | Homo sapiens | PubChem 104895 | - | Gi1/&β;1/&γ;2 | 2.84 | 2023-05-10 | 10.1038/s41467-023-37112-9 | |
8GUS | A | Lipid | Cannabinoid | CB2 | Homo sapiens | HU-308 | - | Gi1/&β;1/&γ;2 | 2.97 | 2023-05-10 | 10.1038/s41467-023-37112-9 | |
8GUT | A | Lipid | Cannabinoid | CB2 | Homo sapiens | LEI-102 | - | Gi1/&β;1/&γ;2 | 2.98 | 2023-05-10 | 10.1038/s41467-023-37112-9 | |
7EZH | A | Peptide | Cholecystokinin | CCKA | Homo sapiens | Cholecystokinin-8 | - | Gi1/&β;1/&γ;2 | 3.2 | 2021-08-25 | 10.1038/s41589-021-00841-3 | |
7EZK | A | Peptide | Cholecystokinin | CCKA | Homo sapiens | Cholecystokinin-8 | - | chim(NtGi1-Gs)/&β;1/&γ;2 | 3.1 | 2021-08-25 | 10.1038/s41589-021-00841-3 | |
7EZM | A | Peptide | Cholecystokinin | CCKA | Homo sapiens | Cholecystokinin-8 | - | chim(NtGsL-Gq)/&β;1/&γ;2 | 2.9 | 2021-08-25 | 10.1038/s41589-021-00841-3 | |
7MBX | A | Peptide | Cholecystokinin | CCKA | Homo sapiens | Cholecystokinin-8 | - | Gs/&β;1/&γ;1 | 1.95 | 2021-05-26 | 10.1371/journal.pbio.3001295 | |
7MBY | A | Peptide | Cholecystokinin | CCKA | Homo sapiens | Cholecystokinin-8 | - | chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 | 2.44 | 2021-05-26 | 10.1371/journal.pbio.3001295 | |
7XOU | A | Peptide | Cholecystokinin | CCKA | Homo sapiens | Cholecystokinin-8 | - | Gs/&β;1/&γ;2 | 3.2 | 2022-07-20 | 10.1038/s41421-022-00420-3 | |
7XOV | A | Peptide | Cholecystokinin | CCKA | Homo sapiens | SR146131 | - | Gs/&β;1/&γ;2 | 3 | 2022-07-20 | 10.1038/s41421-022-00420-3 | |
7F8V | A | Peptide | Cholecystokinin | CCKB | Homo sapiens | Gastrin-17 | - | Gi2/&β;1/&γ;2 | 3.3 | 2021-10-13 | 10.1038/s41589-021-00866-8 | |
7F8W | A | Peptide | Cholecystokinin | CCKB | Homo sapiens | Gastrin-17 | - | chim(NtGsL-Gq)/&β;1/&γ;2 | 3.1 | 2021-10-13 | 10.1038/s41589-021-00866-8 | |
7XOW | A | Peptide | Cholecystokinin | CCKB | Homo sapiens | Gastrin | - | Gq/&β;1/&γ;2 | 3.1 | 2022-07-20 | 10.1038/s41421-022-00420-3 | |
7XOX | A | Peptide | Cholecystokinin | CCKB | Homo sapiens | Cholecystokinin-8 | - | Gq/&β;1/&γ;2 | 3.1 | 2022-07-20 | 10.1038/s41421-022-00420-3 | |
8IA7 | A | Peptide | Cholecystokinin | CCKB | Homo sapiens | Cholecystokinin-8 | - | chim(NtGi1L-Gq)/&β;1/&γ;2 | 3.1 | 2023-12-06 | 10.1038/s41421-022-00420-3 | |
7VL8 | A | Protein | Chemokine | CCR1 | Homo sapiens | - | - | Gi1/&β;1/&γ;2 | 2.9 | 2022-03-23 | 10.1038/s41589-021-00918-z | |
7VL9 | A | Protein | Chemokine | CCR1 | Homo sapiens | CCL15(26-92) | - | Gi1/&β;1/&γ;2 | 2.6 | 2022-03-23 | 10.1038/s41589-021-00918-z | |
7VLA | A | Protein | Chemokine | CCR1 | Homo sapiens | CCL15(27-92) | - | Gi1/&β;1/&γ;2 | 2.7 | 2022-03-23 | 10.1038/s41589-021-00918-z | |
7XA3 | A | Protein | Chemokine | CCR2 | Homo sapiens | CCL2 | - | Gi1/&β;1/&γ;2 | 2.9 | 2022-08-24 | 10.1038/s41421-022-00403-4 | |
7X9Y | A | Protein | Chemokine | CCR3 | Homo sapiens | - | - | Gi1/&β;1/&γ;2 | 3.1 | 2022-08-24 | 10.1038/s41421-022-00403-4 | |
7F1Q | A | Protein | Chemokine | CCR5 | Homo sapiens | MIP-1a | - | Gi1/&β;1/&γ;2 | 2.9 | 2021-07-14 | 10.1038/s41467-021-24438-5 | |
7F1R | A | Protein | Chemokine | CCR5 | Homo sapiens | - | - | Gi1/&β;1/&γ;2 | 3 | 2021-07-14 | 10.1038/s41467-021-24438-5 | |
7F1S | A | Protein | Chemokine | CCR5 | Homo sapiens | - | - | Gi1/&β;1/&γ;2 | 2.8 | 2021-07-14 | 10.1038/s41467-021-24438-5 | |
7O7F | A | Protein | Chemokine | CCR5 | Homo sapiens | (6P4)CCL5 | - | Gi1/&β;1/&γ;1 | 3.15 | 2021-06-30 | 10.1126/sciadv.abg8685 | |
6WWZ | A | Protein | Chemokine | CCR6 | Homo sapiens | CCL20 | - | Go/&β;1/&γ;2 | 3.34 | 2020-06-24 | 10.1038/s41467-020-16820-6 | |
8KFX | A | Protein | Chemokine | CCR8 | Homo sapiens | LMD-009 | - | Gi1/&β;1/&γ;2 | 2.96 | 2024-02-07 | 10.1126/sciadv.adj7500 | |
8KFY | A | Protein | Chemokine | CCR8 | Homo sapiens | ZK-756326 | - | Gi1/&β;1/&γ;2 | 3.06 | 2024-02-07 | 10.1126/sciadv.adj7500 | |
8KFZ | A | Protein | Chemokine | CCR8 | Homo sapiens | - | - | Gi1/&β;1/&γ;2 | 3.3 | 2024-02-07 | 10.1126/sciadv.adj7500 | |
8U1U | A | Protein | Chemokine | CCR8 | Homo sapiens | CCL1 | - | Gi1/&β;1/&γ;2 | 3.1 | 2023-12-20 | 10.1038/s41467-023-43601-8 | |
7YKD | A | Protein | Chemerin | CML1 | Homo sapiens | Chemerin-9 | - | Gi1/&β;1/&γ;2 | 2.81 | 2023-04-19 | 10.1073/pnas.2214324120 | |
8SG1 | A | Protein | Chemerin | CML1 | Homo sapiens | Chemerin-9 | - | Gi1/&β;1/&γ;2 | 2.94 | 2023-11-01 | 10.1371/journal.pbio.3002188 | |
6P9X | B1 | Peptide | Corticotropin Releasing Factor | CRF1 | Homo sapiens | Corticoliberin | - | Gs/&β;1/&γ;2 | 2.91 | 2020-02-05 | 10.1016/j.molcel.2020.01.012 | |
6PB0 | B1 | Peptide | Corticotropin Releasing Factor | CRF1 | Homo sapiens | Urocortin | - | chim(NtGi1-Gs)/&β;1/&γ;2 | 3 | 2020-02-12 | 10.1016/j.molcel.2020.01.013 | |
6PB1 | B1 | Peptide | Corticotropin Releasing Factor | CRF2 | Homo sapiens | Urocortin | - | chim(NtGi1-Gs)/&β;1/&γ;2 | 2.8 | 2020-02-12 | 10.1016/j.molcel.2020.01.013 | |
7TRY | B1 | Peptide | Corticotropin Releasing Factor | CRF2 | Homo sapiens | Urocortin | - | chim(NtGi1-G11)/&β;1/&γ;2 | 3.7 | 2022-11-09 | 10.1038/s41467-022-33851-3 | |
7TS0 | B1 | Peptide | Corticotropin Releasing Factor | CRF2 | Homo sapiens | Urocortin | - | chim(NtGi1L-Go)/&β;1/&γ;2 | 2.8 | 2022-11-09 | 10.1038/s41467-022-33851-3 | |
5UZ7 | B1 | Peptide | Calcitonin | CT | Homo sapiens | - | - | Gs/&β;1/&γ;2 | 4.1 | 2017-05-03 | 10.1038/nature22327 | |
6NIY | B1 | Peptide | Calcitonin | CT | Homo sapiens | Adrenomedullin | - | Gs/&β;1/&γ;2 | 3.34 | 2019-01-23 | 10.1021/acsptsci.8b00056 | |
7TYI | B1 | Peptide | Calcitonin | CT | Homo sapiens | Amylin | - | Gs/&β;1/&γ;2 | 3.3 | 2022-03-30 | 10.1126/science.abm9609 | |
7TYL | B1 | Peptide | Calcitonin | CT | Homo sapiens | Amylin | - | Gs/&β;1/&γ;2 | 3.3 | 2022-03-23 | 10.1126/science.abm9609 | |
7TYN | B1 | Peptide | Calcitonin | CT | Homo sapiens | Calcitonin-1 | - | Gs/&β;1/&γ;2 | 2.6 | 2022-03-30 | 10.1126/science.abm9609 | |
7TYO | B1 | Peptide | Calcitonin | CT | Homo sapiens | Calcitonin | - | Gs/&β;1/&γ;2 | 2.7 | 2022-03-23 | 10.1126/science.abm9609 | |
8F0J | B1 | Peptide | Calcitonin | CT | Homo sapiens | Pramlintide analogue san45 | - | Gs/&β;1/&γ;2 | 2 | 2023-08-02 | 10.1038/s41589-023-01393-4 | |
9AUC | B1 | Peptide | Calcitonin | CT | Homo sapiens | Calcitonin gene-related peptide-1 | - | Gs/&β;1/&γ;2; RAMP1 | 2.4 | 2024-04-24 | 10.1021/acs.biochem.4c00114 | |
7TYF | B1 | Peptide | Calcitonin | CT (AMY1) | Homo sapiens | Amylin | - | Gs/&β;1/&γ;2; RAMP1 | 2.2 | 2022-03-23 | 10.1126/science.abm9609 | |
7TYW | B1 | Peptide | Calcitonin | CT (AMY1) | Homo sapiens | Calcitonin-1 | - | Gs/&β;1/&γ;2; RAMP1 | 3 | 2022-03-23 | 10.1126/science.abm9609 | |
7TYH | B1 | Peptide | Calcitonin | CT (AMY2) | Homo sapiens | Calcitonin-1 | - | Gs/&β;1/&γ;2; RAMP2 | 3.3 | 2022-03-23 | 10.1126/science.abm9609 | |
7TYX | B1 | Peptide | Calcitonin | CT (AMY2) | Homo sapiens | Amylin | - | Gs/&β;1/&γ;2; RAMP2 | 2.55 | 2022-03-30 | 10.1126/science.abm9609 | |
7TYY | B1 | Peptide | Calcitonin | CT (AMY2) | Homo sapiens | Calcitonin-1 | - | Gs/&β;1/&γ;2; RAMP2 | 3 | 2022-03-23 | 10.1126/science.abm9609 | |
7TZF | B1 | Peptide | Calcitonin | CT (AMY3) | Homo sapiens | Amylin | - | Gs/&β;1/&γ;2; RAMP3 | 2.4 | 2022-03-23 | 10.1126/science.abm9609 | |
8F0K | B1 | Peptide | Calcitonin | CT (AMY3) | Homo sapiens | Pramlintide analogue san385 | - | Gs/&β;1/&γ;2; RAMP3 | 1.9 | 2023-08-02 | 10.1038/s41589-023-01393-4 | |
8F2A | B1 | Peptide | Calcitonin | CT (AMY3) | Homo sapiens | Pramlintide analogue san385 | - | Gs/&β;1/&γ;2; RAMP3 | 2.2 | 2023-08-02 | 10.1038/s41589-023-01393-4 | |
8F2B | B1 | Peptide | Calcitonin | CT (AMY3) | Homo sapiens | Pramlintide analogue san45 | - | Gs/&β;1/&γ;2; RAMP3 | 2 | 2023-08-02 | 10.1038/s41589-023-01393-4 | |
6E3Y | B1 | Peptide | Calcitonin | CT Like | Homo sapiens | Calcitonin gene-related peptide-1 | - | Gs/&β;1/&γ;2; RAMP1 | 3.3 | 2018-09-19 | 10.1038/s41586-018-0535-y | |
6UUN | B1 | Peptide | Calcitonin | CT Like (AM1) | Homo sapiens | Adrenomedullin | - | Gs/&β;1/&γ;2; RAMP2 | 3 | 2020-03-25 | 10.1021/acsptsci.9b00080 | |
6UUS | B1 | Peptide | Calcitonin | CT Like (AM2) | Homo sapiens | Adrenomedullin | - | Gs/&β;1/&γ;2; RAMP3 | 2.4 | 2020-04-01 | 10.1021/acsptsci.9b00080 | |
6UVA | B1 | Peptide | Calcitonin | CT Like (AM2) | Homo sapiens | Adrenomedullin-2 | - | Gs/&β;1/&γ;2; RAMP3 | 2.3 | 2020-04-01 | 10.1021/acsptsci.9b00080 | |
7XBW | A | Protein | Chemokine | CX3CR1 | Homo sapiens | - | - | Gi1/&β;1/&γ;2 | 2.8 | 2022-07-13 | 10.1126/sciadv.abn8048 | |
7XBX | A | Protein | Chemokine | CX3CR1 | Homo sapiens | CX3CL1 | - | Gi1/&β;1/&γ;2 | 3.4 | 2022-07-13 | 10.1126/sciadv.abn8048 | |
8IC0 | A | Protein | Chemokine | CXCR1 | Homo sapiens | Interleukin-8 | - | Gi1/&β;1/&γ;2 | 3.41 | 2023-07-19 | 10.1038/s41467-023-39799-2 | |
6LFM | A | Protein | Chemokine | CXCR2 | Homo sapiens | Interleukin-8 | - | Gi1/&β;1/&γ;2 | 3.5 | 2020-09-02 | 10.1038/s41586-020-2492-5 | |
6LFO | A | Protein | Chemokine | CXCR2 | Homo sapiens | Interleukin-8 | - | Gi1/&β;1/&γ;2 | 3.4 | 2020-09-02 | 10.1038/s41586-020-2492-5 | |
8HNK | A | Protein | Chemokine | CXCR3 | Homo sapiens | CXCL11 | - | Gi1/&β;1/&γ;2 | 3.01 | 2023-11-29 | 10.1038/s41594-023-01175-5 | |
8HNL | A | Protein | Chemokine | CXCR3 | Homo sapiens | PS372424 | - | Gi1/&β;1/&γ;2 | 2.98 | 2023-11-29 | 10.1038/s41594-023-01175-5 | |
8HNM | A | Protein | Chemokine | CXCR3 | Homo sapiens | VUF11222 | - | Gi1/&β;1/&γ;2 | 2.94 | 2023-11-29 | 10.1038/s41594-023-01175-5 | |
8K2X | A | Protein | Chemokine | CXCR3 | Homo sapiens | CXCL10 | - | Gi1/&β;1/&γ;2 | 3.2 | 2023-11-29 | 10.1038/s41594-023-01175-5 | |
8U4N | A | Protein | Chemokine | CXCR4 | Homo sapiens | - | Cholesterol | Gi1/&β;1/&γ;2 | 2.72 | 2024-03-13 | 10.1101/2024.02.09.579708 | |
8U4O | A | Protein | Chemokine | CXCR4 | Homo sapiens | CXCL12 | Cholesterol | Gi1/&β;1/&γ;2 | 3.29 | 2024-03-13 | 10.1101/2024.02.09.579708 | |
8U4P | A | Protein | Chemokine | CXCR4 | Homo sapiens | AMD3100 | Cholesterol | Gi1/&β;1/&γ;2 | 3.15 | 2024-03-13 | 10.1101/2024.02.09.579708 | |
8U4Q | A | Protein | Chemokine | CXCR4 | Homo sapiens | REGN7663-Fab | Cholesterol | Gi1/&β;1/&γ;2 | 3.36 | 2024-03-13 | 10.1101/2024.02.09.579708 | |
7CKW | A | Amine | Dopamine | D1 | Homo sapiens | Fenoldopam | - | Gs/&β;1/&γ;2 | 3.22 | 2021-03-03 | 10.1016/j.cell.2021.01.028 | |
7CKX | A | Amine | Dopamine | D1 | Homo sapiens | A77636 | - | Gs/&β;1/&γ;2 | 3.54 | 2021-03-03 | 10.1016/j.cell.2021.01.028 | |
7CKY | A | Amine | Dopamine | D1 | Homo sapiens | PW0464 | - | Gs/&β;1/&γ;2 | 3.2 | 2021-03-03 | 10.1016/j.cell.2021.01.028 | |
7CKZ | A | Amine | Dopamine | D1 | Homo sapiens | Dopamine | Mevidalen | Gs/&β;1/&γ;2 | 3.1 | 2021-03-03 | 10.1016/j.cell.2021.01.028 | |
7CRH | A | Amine | Dopamine | D1 | Homo sapiens | SKF83959 | - | Gs/&β;1/&γ;2 | 3.3 | 2021-03-03 | 10.1016/j.cell.2021.01.028 | |
7F0T | A | Amine | Dopamine | D1 | Homo sapiens | Dopamine | - | Gs/&β;1/&γ;2 | 3.1 | 2022-06-15 | 10.1126/sciadv.abo4158 | |
7F1O | A | Amine | Dopamine | D1 | Homo sapiens | Dopamine | GDP; Mg | Gs/&β;1/&γ;2 | 3.13 | 2022-06-15 | 10.1126/sciadv.abo4158 | |
7F1Z | A | Amine | Dopamine | D1 | Homo sapiens | Dopamine | GDP | Gs/&β;1/&γ;2 | 3.46 | 2022-06-15 | 10.1126/sciadv.abo4158 | |
7F23 | A | Amine | Dopamine | D1 | Homo sapiens | Dopamine | GDP | Gs/&β;1/&γ;2 | 3.58 | 2022-06-15 | 10.1126/sciadv.abo4158 | |
7F24 | A | Amine | Dopamine | D1 | Homo sapiens | Dopamine | GDP | Gs/&β;1/&γ;2 | 4.16 | 2022-06-15 | 10.1126/sciadv.abo4158 | |
7JOZ | A | Amine | Dopamine | D1 | Homo sapiens | VFP | - | Gs/&β;1/&γ;2 | 3.8 | 2021-04-14 | 10.1038/s41467-021-23519-9 | |
7JV5 | A | Amine | Dopamine | D1 | Homo sapiens | SKF81297 | - | Gs/&β;1/&γ;2 | 3 | 2021-02-24 | 10.1016/j.cell.2021.01.027 | |
7JVP | A | Amine | Dopamine | D1 | Homo sapiens | SKF83959 | - | Gs/&β;1/&γ;2 | 2.9 | 2021-02-24 | 10.1016/j.cell.2021.01.027 | |
7JVQ | A | Amine | Dopamine | D1 | Homo sapiens | Apomorphine | - | Gs/&β;1/&γ;2 | 3 | 2021-02-24 | 10.1016/j.cell.2021.01.027 | |
7LJC | A | Amine | Dopamine | D1 | Homo sapiens | PubChem 86764103 | Mevidalen | Gs/&β;1/&γ;2 | 3 | 2021-03-03 | 10.1038/s41422-021-00482-0 | |
7LJD | A | Amine | Dopamine | D1 | Homo sapiens | Dopamine | Mevidalen | Gs/&β;1/&γ;1 | 3.2 | 2021-03-03 | 10.1038/s41422-021-00482-0 | |
7X2C | A | Amine | Dopamine | D1 | Homo sapiens | Fenoldopam | Fenoldopam | Gs/&β;1/&γ;2 | 3.2 | 2022-06-29 | 10.1038/s41467-022-30929-w | |
7X2D | A | Amine | Dopamine | D1 | Homo sapiens | Tavapadon | - | Gs/&β;1/&γ;2 | 3.3 | 2022-06-15 | 10.1038/s41467-022-30929-w | |
7X2F | A | Amine | Dopamine | D1 | Homo sapiens | Dopamine | Mevidalen | Gs/&β;1/&γ;2 | 3 | 2022-06-15 | 10.1038/s41467-022-30929-w | |
8IRR | A | Amine | Dopamine | D1 | Homo sapiens | Rotigotine | - | Gs/&β;1/&γ;2 | 3.2 | 2023-06-07 | 10.1038/s41422-023-00808-0 | |
6VMS | A | Amine | Dopamine | D2 | Homo sapiens | Bromoergocryptine | - | Gi1/&β;1/&γ;2 | 3.8 | 2020-06-17 | 10.1038/s41586-020-2379-5 | |
7JVR | A | Amine | Dopamine | D2 | Homo sapiens | Bromoergocryptine | - | Gi1/&β;1/&γ;2 | 2.8 | 2021-02-24 | 10.1016/j.cell.2021.01.027 | |
8IRS | A | Amine | Dopamine | D2 | Homo sapiens | Rotigotine | - | Gi1/&β;1/&γ;2 | 3 | 2023-06-07 | 10.1038/s41422-023-00808-0 | |
7CMU | A | Amine | Dopamine | D3 | Homo sapiens | Pramipexole | - | Gi1/&β;1/&γ;2 | 3 | 2021-03-10 | 10.1016/j.molcel.2021.01.003 | |
7CMV | A | Amine | Dopamine | D3 | Homo sapiens | PD128907 | - | Gi1/&β;1/&γ;2 | 2.7 | 2021-03-10 | 10.1016/j.molcel.2021.01.003 | |
8IRT | A | Amine | Dopamine | D3 | Homo sapiens | Rotigotine | - | Gi1/&β;1/&γ;2 | 2.7 | 2023-06-07 | 10.1038/s41422-023-00808-0 | |
8IRU | A | Amine | Dopamine | D4 | Homo sapiens | Rotigotine | - | chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2 | 3.2 | 2023-06-07 | 10.1038/s41422-023-00808-0 | |
8IRV | A | Amine | Dopamine | D5 | Homo sapiens | Rotigotine | - | chim(NtGi1-Gs)/&β;1/&γ;2 | 3.1 | 2023-06-07 | 10.1038/s41422-023-00808-0 | |
8F7S | A | Peptide | Opioid | δ | Homo sapiens | Deltorphin | - | Gi1/&β;1/&γ;2 | 3 | 2022-12-14 | 10.1016/j.cell.2022.12.026 | |
7CX2 | A | Lipid | Prostanoid | EP2 | Homo sapiens | PGE2 | - | Gs/&β;1/&γ;2 | 2.8 | 2021-05-05 | 10.1126/sciadv.abf1268 | |
7CX3 | A | Lipid | Prostanoid | EP2 | Homo sapiens | Taprenepag | - | Gs/&β;1/&γ;2 | 2.8 | 2021-05-05 | 10.1126/sciadv.abf1268 | |
7CX4 | A | Lipid | Prostanoid | EP2 | Homo sapiens | Evatanepag | - | Gs/&β;1/&γ;2 | 2.9 | 2021-05-05 | 10.1126/sciadv.abf1268 | |
7WU9 | A | Lipid | Prostanoid | EP3 | Homo sapiens | - | - | Gi1/&β;1/&γ;2 | 3.38 | 2022-08-17 | 10.1016/j.celrep.2022.111323 | |
8GDC | A | Lipid | Prostanoid | EP3 | Homo sapiens | PGE2 | - | Gi1/&β;1/&γ;2 | 3.5 | 2024-01-03 | 10.1073/pnas.2216329120 | |
7D7M | A | Lipid | Prostanoid | EP4 | Homo sapiens | Dinoprostone | - | Gs/&β;1/&γ;1 | 3.3 | 2020-11-18 | 10.1016/j.str.2020.11.007 | |
8GCM | A | Lipid | Prostanoid | EP4 | Homo sapiens | L902688 | - | Gi1/&β;1/&γ;2 | 3.5 | 2024-01-03 | 10.1073/pnas.2216329120 | |
8GCP | A | Lipid | Prostanoid | EP4 | Homo sapiens | PGE2 | - | Gi1/&β;1/&γ;2 | 3.1 | 2024-01-03 | 10.1073/pnas.2216329120 | |
8GD9 | A | Lipid | Prostanoid | EP4 | Homo sapiens | Rivenprost | - | Gs/&β;1/&γ;2 | 3.2 | 2024-01-03 | 10.1073/pnas.2216329120 | |
8GDA | A | Lipid | Prostanoid | EP4 | Homo sapiens | L902688 | - | Gs/&β;1/&γ;2 | 3.3 | 2024-01-03 | 10.1073/pnas.2216329120 | |
8GDB | A | Lipid | Prostanoid | EP4 | Homo sapiens | PGE2 | - | Gs/&β;1/&γ;2 | 3.1 | 2024-01-03 | 10.1073/pnas.2216329120 | |
8HCQ | A | Peptide | Endothelin | ETA | Homo sapiens | Endothelin-1 | - | chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 | 3.01 | 2023-03-22 | 10.1038/s41467-023-36998-9 | |
8HBD | A | Peptide | Endothelin | ETB | Homo sapiens | IRL1620 | - | Gi1/&β;1/&γ;2 | 2.99 | 2023-03-22 | 10.1038/s41467-023-36998-9 | |
8HCX | A | Peptide | Endothelin | ETB | Homo sapiens | Endothelin-1 | - | chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 | 3.5 | 2023-03-22 | 10.1038/s41467-023-36998-9 | |
8IY5 | A | Peptide | Endothelin | ETB | Homo sapiens | Endothelin-1 | - | Gi1/&β;1/&γ;2 | 2.8 | 2023-08-16 | 10.7554/eLife.85821 | |
8T3V | A | Lipid | Free fatty acid | FFA1 | Homo sapiens | DHA | - | chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 | 3.39 | 2024-01-24 | 10.1126/sciadv.adj2384 | |
8EIT | A | Lipid | Free fatty acid | FFA1 (GPR40) | Homo sapiens | Doconexent | - | chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 | 2.8 | 2023-05-24 | 10.1073/pnas.2219569120 | |
8EJC | A | Lipid | Free fatty acid | FFA1 (GPR40) | Homo sapiens | TAK-875 | - | chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 | 3 | 2023-05-24 | 10.1073/pnas.2219569120 | |
8EJK | A | Lipid | Free fatty acid | FFA1 (GPR40) | Homo sapiens | TAK-875 | - | chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 | 3.4 | 2023-05-24 | 10.1073/pnas.2219569120 | |
8J22 | A | Lipid | Free fatty acid | FFA2 | Homo sapiens | TUG-1375 | - | Gi1/&β;1/&γ;2 | 3.2 | 2024-01-24 | 10.1038/s41422-023-00914-z | |
8J23 | A | Lipid | Free fatty acid | FFA2 | Homo sapiens | - | - | Gi1/&β;1/&γ;2 | 3.2 | 2024-04-17 | To be published | |
8J24 | A | Lipid | Free fatty acid | FFA2 | Homo sapiens | Acetic acid | - | Gi1/&β;1/&γ;2 | 2.6 | 2024-01-24 | 10.1038/s41422-023-00914-z | |
8T3S | A | Lipid | Free fatty acid | FFA2 | Homo sapiens | Butyric acid | - | chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 | 3.07 | 2024-01-24 | 10.1126/sciadv.adj2384 | |
8J20 | A | Lipid | Free fatty acid | FFA3 | Homo sapiens | Valeric acid | AR420626 | Gi1/&β;1/&γ;2 | 3.2 | 2024-01-24 | 10.1038/s41422-023-00914-z | |
8J21 | A | Lipid | Free fatty acid | FFA3 | Homo sapiens | Butyric acid | - | Gi1/&β;1/&γ;2 | 3.3 | 2024-01-24 | 10.1038/s41422-023-00914-z | |
8H4I | A | Lipid | Free fatty acid | FFA4 | Homo sapiens | Doconexent | - | chim(NtGi1-Gs)/&β;1/&γ;2 | 3.06 | 2023-06-21 | 10.1038/s41422-023-00835-x | |
8H4K | A | Lipid | Free fatty acid | FFA4 | Homo sapiens | GW9508 | - | chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 | 3.1 | 2023-06-21 | 10.1038/s41422-023-00835-x | |
8H4L | A | Lipid | Free fatty acid | FFA4 | Homo sapiens | Doconexent | - | chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 | 3.07 | 2023-06-21 | 10.1038/s41422-023-00835-x | |
8IYS | A | Lipid | Free fatty acid | FFA4 | Homo sapiens | TUG-891 | GDP | chim(NtGi1L-Gq)/&β;1/&γ;2 | 2.95 | 2023-06-21 | 10.1038/s41422-023-00835-x | |
8T3O | A | Lipid | Free fatty acid | FFA4 | Homo sapiens | TUG-891 | 2Y5 | chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 | 3.06 | 2024-01-17 | 10.1126/sciadv.adj2384 | |
8T3Q | A | Lipid | Free fatty acid | FFA4 | Homo sapiens | DHA | - | chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 | 3.14 | 2024-01-24 | 10.1126/sciadv.adj2384 | |
8G59 | A | Lipid | Free fatty acid | FFA4 (GPR120) | Homo sapiens | TUG-891 | - | Gi1/&β;1/&γ;2 | 2.64 | 2023-03-08 | 10.1126/science.add6220 | |
8ID3 | A | Lipid | Free fatty acid | FFA4 (GPR120) | Homo sapiens | 9-Hydroxystearic acid | - | Gi1/&β;1/&γ;2 | 3.1 | 2023-03-15 | 10.1126/science.add6220 | |
8ID4 | A | Lipid | Free fatty acid | FFA4 (GPR120) | Homo sapiens | Linoleic acid | - | Gi1/&β;1/&γ;2 | 3.1 | 2023-03-15 | 10.1126/science.add6220 | |
8ID6 | A | Lipid | Free fatty acid | FFA4 (GPR120) | Homo sapiens | Oleic acid | - | Gi1/&β;1/&γ;2 | 2.8 | 2023-03-15 | 10.1126/science.add6220 | |
8ID8 | A | Lipid | Free fatty acid | FFA4 (GPR120) | Homo sapiens | TUG-891 | - | Gi1/&β;1/&γ;2 | 3 | 2023-03-15 | 10.1126/science.add6220 | |
8ID9 | A | Lipid | Free fatty acid | FFA4 (GPR120) | Homo sapiens | Eicosapentaenoic acid | - | Gi1/&β;1/&γ;2 | 3 | 2023-03-15 | 10.1126/science.add6220 | |
8IQ4 | A | Lipid | Prostanoid | FP-alpha | Homo sapiens | Carboprost | - | chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 | 2.7 | 2024-01-31 | 10.1038/s41467-023-43922-8 | |
8IQ6 | A | Lipid | Prostanoid | FP-alpha | Homo sapiens | Latanoprost | - | chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 | 3.4 | 2024-01-31 | 10.1038/s41467-023-43922-8 | |
8IUK | A | Lipid | Prostanoid | FP-alpha | Homo sapiens | PGF2-alpha | - | chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 | 2.67 | 2023-07-12 | 10.1038/s41467-023-38411-x | |
8IUL | A | Lipid | Prostanoid | FP-alpha | Homo sapiens | Latanoprost | - | chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 | 2.78 | 2023-07-12 | 10.1038/s41467-023-38411-x | |
8IUM | A | Lipid | Prostanoid | FP-alpha | Homo sapiens | Tafluprost acid | - | chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 | 3.14 | 2023-07-12 | 10.1038/s41467-023-38411-x | |
8XJL | A | Lipid | Prostanoid | FP-alpha | Homo sapiens | PGF2-alpha | - | chim(NtGi2-Gs-CtGq)/&β;1/&γ;2 | 2.77 | 2024-02-28 | To be published | |
8XJM | A | Lipid | Prostanoid | FP-alpha | Homo sapiens | Latanoprost | - | chim(NtGi2-Gs-CtGq)/&β;1/&γ;2 | 2.85 | 2024-02-28 | To be published | |
7EUO | A | Peptide | Formylpeptide | FPR1-ALX | Homo sapiens | fMLF | - | Gi1/&β;1/&γ;2 | 2.9 | 2022-05-25 | 10.1038/s41467-022-32822-y | |
7T6T | A | Peptide | Formylpeptide | FPR1-ALX | Homo sapiens | fMLFII | - | Gi1/&β;1/&γ;2 | 3.2 | 2022-03-30 | 10.1038/s41467-022-28586-0 | |
7VFX | A | Peptide | Formylpeptide | FPR1-ALX | Homo sapiens | fMLF | - | Gi1/&β;1/&γ;2 | 2.8 | 2022-09-21 | 10.1038/s41467-022-32822-y | |
7WVU | A | Peptide | Formylpeptide | FPR1-ALX | Homo sapiens | fMLF | - | Gi1/&β;1/&γ;2 | 3.3 | 2022-04-13 | 10.1038/s41467-022-29361-x | |
6OMM | A | Peptide | Formylpeptide | FPR2-ALX | Homo sapiens | WKYMVX | - | Gi1/&β;1/&γ;2 | 3.17 | 2020-02-26 | 10.1038/s41467-020-14728-9 | |
7T6S | A | Peptide | Formylpeptide | FPR2-ALX | Homo sapiens | PubChem 24776341 | - | Gi1/&β;1/&γ;2 | 3 | 2022-03-30 | 10.1038/s41467-022-28586-0 | |
7T6U | A | Peptide | Formylpeptide | FPR2-ALX | Homo sapiens | CGEN-855A | - | Gi1/&β;1/&γ;2 | 2.9 | 2022-03-30 | 10.1038/s41467-022-28586-0 | |
7T6V | A | Peptide | Formylpeptide | FPR2-ALX | Homo sapiens | fMLFII | - | Gi1/&β;1/&γ;2 | 3.1 | 2022-03-30 | 10.1038/s41467-022-28586-0 | |
7WVV | A | Peptide | Formylpeptide | FPR2-ALX | Homo sapiens | fMLFII | - | Gi2/&β;1/&γ;2 | 2.9 | 2022-04-13 | 10.1038/s41467-022-29361-x | |
7WVW | A | Peptide | Formylpeptide | FPR2-ALX | Homo sapiens | fMYFINILTL | - | Gi2/&β;1/&γ;2 | 3.1 | 2022-04-13 | 10.1038/s41467-022-29361-x | |
7WVX | A | Peptide | Formylpeptide | FPR2-ALX | Homo sapiens | Humanin | - | Gi2/&β;1/&γ;2 | 2.8 | 2022-04-13 | 10.1038/s41467-022-29361-x | |
7WVY | A | Peptide | Formylpeptide | FPR2-ALX | Homo sapiens | Amyloid-Beta42 | - | Gi2/&β;1/&γ;2 | 3 | 2022-04-13 | 10.1038/s41467-022-29361-x | |
8I2G | A | Protein | Glycoprotein hormone | FSH | Homo sapiens | Glycoprotein hormones alpha chain | Compound 716340 | Gs/&β;1/&γ;2 | 2.8 | 2023-03-29 | 10.1038/s41467-023-36170-3 | |
8J9N | F | Protein | Frizzled | FZD1 | Homo sapiens | - | - | chim(Gs-CtGq)/&β;1/&γ;2 | 3.5 | 2024-01-17 | 10.1038/s41421-023-00627-y | |
8JHI | F | Protein | Frizzled | FZD3 | Homo sapiens | - | - | chim(NtGsXLas-Gs)/&β;1/&γ;2 | 3.2 | 2024-01-17 | 10.1038/s41421-023-00627-y | |
8JHB | F | Protein | Frizzled | FZD6 | Homo sapiens | - | - | chim(NtGsXLas-Gs)/&β;1/&γ;2 | 3.3 | 2024-01-17 | 10.1038/s41421-023-00627-y | |
7EVW | F | Protein | Frizzled | FZD7 | Homo sapiens | - | - | Gs/&β;1/&γ;2 | 3.22 | 2021-08-04 | 10.1038/s41422-021-00525-6 | |
8YY8 | F | Protein | Frizzled | FZD7 | Homo sapiens | - | - | Gs/&β;1/&γ;2 | 3.22 | 2024-04-24 | 10.1038/s41422-021-00525-6 | |
7EB2 | C | Aminoacid | GABAB | GABAB1, GABAB2 | Homo sapiens | Baclofen | rac-BHFF | Gi1/&β;1/&γ;2 | 3.5 | 2021-05-05 | 10.1038/s41586-021-03507-1 | |
7WQ3 | A | Peptide | Galanin | GAL1 | Homo sapiens | Galanin | - | Gi1/&β;1/&γ;2 | 2.7 | 2022-04-20 | 10.1038/s41467-022-29072-3 | |
7XJJ | A | Peptide | Galanin | GAL1 | Homo sapiens | Galanin | - | Go/&β;1/&γ;2 | 3.3 | 2023-05-03 | 10.1073/pnas.2121465119 | |
7WQ4 | A | Peptide | Galanin | GAL2 | Homo sapiens | Galanin | - | chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 | 2.6 | 2022-04-20 | 10.1038/s41467-022-29072-3 | |
7XBD | A | Peptide | Galanin | GAL2 | Homo sapiens | Galanin | - | chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 | 3.11 | 2022-07-13 | 10.1371/journal.pbio.3001714 | |
7XJK | A | Peptide | Galanin | GAL2 | Homo sapiens | Galanin | - | chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 | 3.3 | 2022-06-29 | 10.1073/pnas.2121465119 | |
7XJL | A | Peptide | Galanin | GAL2 | Homo sapiens | Spexin | - | chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 | 3.5 | 2022-06-29 | 10.1073/pnas.2121465119 | |
7F9Y | A | Peptide | Ghrelin | Ghrelin | Homo sapiens | Ghrelin-28 | - | chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 | 2.9 | 2021-08-18 | 10.1038/s41467-021-25364-2 | |
7F9Z | A | Peptide | Ghrelin | Ghrelin | Homo sapiens | GHRP-6 | - | chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 | 3.2 | 2021-08-18 | 10.1038/s41467-021-25364-2 | |
7NA7 | A | Peptide | Ghrelin | Ghrelin | Homo sapiens | Ghrelin-27 | - | Gi1/&β;1/&γ;2 | 2.7 | 2021-12-15 | 10.1038/s41467-021-26735-5 | |
7NA8 | A | Peptide | Ghrelin | Ghrelin | Homo sapiens | PubChem 178024 | - | Gi1/&β;1/&γ;2 | 2.7 | 2021-12-15 | 10.1038/s41467-021-26735-5 | |
7W2Z | A | Peptide | Ghrelin | Ghrelin | Homo sapiens | Ghrelin | - | Go/&β;1/&γ;2 | 2.8 | 2022-01-19 | 10.1038/s41467-022-27975-9 | |
7CZ5 | B1 | Peptide | Glucagon | GHRH | Homo sapiens | Somatoliberin | - | Gs/&β;1/&γ;2 | 2.6 | 2020-11-18 | 10.1038/s41467-020-18945-0 | |
7V9L | B1 | Peptide | Glucagon | GHRH (SV1) | Homo sapiens | - | - | chim(NtGi1-Gs)/&β;1/&γ;2 | 2.6 | 2022-04-06 | 10.1073/pnas.2106606118 | |
7V9M | B1 | Peptide | Glucagon | GHRH (SV1) | Homo sapiens | Somatoliberin | - | Gs/&β;1/&γ;2 | 3.29 | 2021-10-20 | 10.1073/pnas.2106606118 | |
7DTY | B1 | Peptide | Glucagon | GIP | Homo sapiens | GIP | - | Gs/&β;1/&γ;2 | 2.98 | 2021-08-04 | 10.7554/eLife.68719 | |
7FIN | B1 | Peptide | Glucagon | GIP | Homo sapiens | Peptide-20; GGL | - | Gs/&β;1/&γ;2 | 3.1 | 2022-02-23 | 10.1038/s41467-022-28683-0 | |
7FIY | B1 | Peptide | Glucagon | GIP | Homo sapiens | Tirzepatide | - | Gs/&β;1/&γ;2 | 3.4 | 2022-03-02 | 10.1038/s41467-022-28683-0 | |
7RA3 | B1 | Peptide | Glucagon | GIP | Homo sapiens | GIP | - | chim(NtGi1-Gs)/&β;1/&γ;2 | 3.24 | 2022-04-13 | 10.1073/pnas.2116506119 | |
7RBT | B1 | Peptide | Glucagon | GIP | Homo sapiens | Tirzepatide | PubChem 163183774 | chim(NtGi1-Gs)/&β;1/&γ;2 | 3.08 | 2022-04-13 | 10.1073/pnas.2116506119 | |
7VAB | B1 | Peptide | Glucagon | GIP | Homo sapiens | Non-Acylated Tirzepatide | - | chim(NtGi1-Gs)/&β;1/&γ;2 | 3.2 | 2022-03-02 | 10.1038/s41467-022-28683-0 | |
8ITL | B1 | Peptide | Glucagon | GIP | Homo sapiens | - | - | Gs/&β;1/&γ;2 | 3.23 | 2023-10-18 | 10.1073/pnas.2306145120 | |
8ITM | B1 | Peptide | Glucagon | GIP | Homo sapiens | - | - | Gs/&β;1/&γ;2 | 3.13 | 2023-10-18 | 10.1073/pnas.2306145120 | |
8WA3 | B1 | Peptide | Glucagon | GIP | Homo sapiens | - | - | Gs/&β;1/&γ;2 | 2.86 | 2024-03-06 | 10.1038/s41421-024-00649-0 | |
5VAI | B1 | Peptide | Glucagon | GLP-1 | Oryctolagus cuniculus | GLP-1 | - | Gs/&β;1/&γ;2 | 4.1 | 2017-05-24 | 10.1038/nature22394 | |
6B3J | B1 | Peptide | Glucagon | GLP-1 | Homo sapiens | Exendin-P5 | - | Gs/&β;1/&γ;2 | 3.3 | 2018-02-21 | 10.1038/nature25773 | |
6ORV | B1 | Peptide | Glucagon | GLP-1 | Homo sapiens | - | TT-OAD2 | Gs/&β;1/&γ;2 | 3 | 2020-01-08 | 10.1038/s41586-019-1902-z | |
6VCB | B1 | Peptide | Glucagon | GLP-1 | Homo sapiens | GLP-1 | LSN3160440 | Gs/&β;1/&γ;2 | 3.3 | 2020-07-22 | 10.1038/s41589-020-0589-7 | |
6X18 | B1 | Peptide | Glucagon | GLP-1 | Homo sapiens | GLP-1 | - | Gs/&β;1/&γ;2 | 2.1 | 2020-09-09 | 10.1016/j.molcel.2020.09.020 | |
6X19 | B1 | Peptide | Glucagon | GLP-1 | Homo sapiens | CHU-128 | - | Gs/&β;1/&γ;2 | 2.1 | 2020-09-09 | 10.1016/j.molcel.2020.09.020 | |
6X1A | B1 | Peptide | Glucagon | GLP-1 | Homo sapiens | Danuglipron | - | Gs/&β;1/&γ;2 | 2.5 | 2020-09-09 | 10.1016/j.molcel.2020.09.020 | |
6XOX | B1 | Peptide | Glucagon | GLP-1 | Homo sapiens | Orforglipron | - | chim(NtGi1-Gs)/&β;1/&γ;2 | 3.1 | 2020-11-18 | 10.1073/pnas.2014879117 | |
7C2E | B1 | Peptide | Glucagon | GLP-1 | Homo sapiens | PubChem 149050799 | - | Gs/&β;1/&γ;2 | 4.2 | 2020-08-26 | 10.1038/s41422-020-0384-8 | |
7DUQ | B1 | Peptide | Glucagon | GLP-1 | Homo sapiens | GLP-1 | PubChem 156022738 | Gs/&β;1/&γ;2 | 2.5 | 2021-07-14 | 10.1038/s41467-021-24058-z | |
7DUR | B1 | Peptide | Glucagon | GLP-1 | Homo sapiens | - | PubChem 156022738 | Gs/&β;1/&γ;2 | 3.3 | 2021-08-11 | 10.1038/s41467-021-24058-z | |
7E14 | B1 | Peptide | Glucagon | GLP-1 | Homo sapiens | Orforglipron | PubChem 156022738 | Gs/&β;1/&γ;2 | 2.9 | 2021-07-07 | 10.1038/s41467-021-24058-z | |
7EVM | B1 | Peptide | Glucagon | GLP-1 | Homo sapiens | - | PubChem 156022738 | Gs/&β;1/&γ;2 | 2.5 | 2021-08-11 | 10.1038/s41467-021-24058-z | |
7FIM | B1 | Peptide | Glucagon | GLP-1 | Homo sapiens | Tirzepatide | - | Gs/&β;1/&γ;2 | 3.4 | 2022-03-02 | 10.1038/s41467-022-28683-0 | |
7KI0 | B1 | Peptide | Glucagon | GLP-1 | Homo sapiens | Semaglutide | - | Gs/&β;1/&γ;2 | 2.5 | 2021-08-04 | 10.1016/j.celrep.2021.109374 | |
7KI1 | B1 | Peptide | Glucagon | GLP-1 | Homo sapiens | Taspoglutide | - | Gs/&β;1/&γ;2 | 2.5 | 2021-08-04 | 10.1016/j.celrep.2021.109374 | |
7LCI | B1 | Peptide | Glucagon | GLP-1 | Homo sapiens | Danuglipron | - | Gs/&β;1/&γ;2 | 2.9 | 2021-01-20 | 10.1016/j.str.2021.04.008 | |
7LLL | B1 | Peptide | Glucagon | GLP-1 | Homo sapiens | Exendin-4 | - | Gs/&β;1/&γ;2 | 3.7 | 2022-01-12 | 10.1038/s41467-021-27760-0 | |
7LLY | B1 | Peptide | Glucagon | GLP-1 | Homo sapiens | Oxyntomodulin | - | Gs/&β;1/&γ;2 | 3.3 | 2022-01-12 | 10.1038/s41467-021-27760-0 | |
7RG9 | B1 | Peptide | Glucagon | GLP-1 | Homo sapiens | - | - | chim(NtGi1-Gs)/&β;1/&γ;2 | 3.2 | 2022-04-13 | 10.1073/pnas.2116506119 | |
7RGP | B1 | Peptide | Glucagon | GLP-1 | Homo sapiens | Tirzepatide | - | chim(NtGi1-Gs)/&β;1/&γ;2 | 2.9 | 2022-04-13 | 10.1073/pnas.2116506119 | |
7RTB | B1 | Peptide | Glucagon | GLP-1 | Homo sapiens | Peptide-19 | - | Gs/&β;1/&γ;2 | 2.14 | 2021-10-06 | 10.1016/j.bbrc.2021.09.016 | |
7S1M | B1 | Peptide | Glucagon | GLP-1 | Homo sapiens | Ex4-D-Ala | - | Gs/&β;1/&γ;2 | 2.41 | 2022-01-05 | 10.1038/s41589-021-00945-w | |
7S3I | B1 | Peptide | Glucagon | GLP-1 | Homo sapiens | - | - | Gs/&β;1/&γ;2 | 2.51 | 2022-01-05 | 10.1038/s41589-021-00945-w | |
7VBH | B1 | Peptide | Glucagon | GLP-1 | Homo sapiens | Peptide-20 | - | Gs/&β;1/&γ;2 | 3 | 2022-04-06 | 10.1038/s41467-022-28683-0 | |
7VBI | B1 | Peptide | Glucagon | GLP-1 | Homo sapiens | Non-Acylated Tirzepatide | - | Gs/&β;1/&γ;2 | 3 | 2022-03-02 | 10.1038/s41467-022-28683-0 | |
7X8R | B1 | Peptide | Glucagon | GLP-1 | Homo sapiens | BOC5 | - | Gs/&β;1/&γ;2 | 2.61 | 2022-06-29 | 10.1073/pnas.2200155119 | |
7X8S | B1 | Peptide | Glucagon | GLP-1 | Homo sapiens | WB4-24 | - | Gs/&β;1/&γ;2 | 3.09 | 2022-06-29 | 10.1073/pnas.2200155119 | |
8JIP | B1 | Peptide | Glucagon | GLP-1 | Homo sapiens | MEDI0382 | - | chim(NtGi1-Gs)/&β;1/&γ;2 | 2.85 | 2023-09-06 | 10.1073/pnas.2303696120 | |
8JIR | B1 | Peptide | Glucagon | GLP-1 | Homo sapiens | SAR425899 | - | chim(NtGi1-Gs)/&β;1/&γ;2 | 2.57 | 2023-09-06 | 10.1073/pnas.2303696120 | |
8JIS | B1 | Peptide | Glucagon | GLP-1 | Homo sapiens | Peptide-15 | - | chim(NtGi1-Gs)/&β;1/&γ;2 | 2.46 | 2023-11-08 | 10.1073/pnas.2303696120 | |
8WG7 | B1 | Peptide | Glucagon | GLP-1 | Homo sapiens | - | - | Gs/&β;1/&γ;2 | 2.54 | 2024-03-06 | 10.1038/s41421-024-00649-0 | |
7D68 | B1 | Peptide | Glucagon | GLP-2 | Homo sapiens | GLP-2 | - | Gs/&β;1/&γ;2 | 3 | 2020-12-16 | 10.1038/s41422-020-00442-0 | |
6LMK | B1 | Peptide | Glucagon | Glucagon | Homo sapiens | Glucagon | - | Gs/&β;1/&γ;2 | 3.7 | 2020-04-01 | 10.1126/science.aaz5346 | |
6WHC | B1 | Peptide | Glucagon | Glucagon | Homo sapiens | Glu16 analog of GCG | - | Gs/&β;1/&γ;2 | 3.4 | 2020-05-27 | 10.1074/jbc.RA120.013793 | |
6WPW | B1 | Peptide | Glucagon | Glucagon | Homo sapiens | Glucagon derivative ZP3780 | - | Gs/&β;1/&γ;2 | 3.1 | 2020-08-12 | 10.1126/science.aba3373 | |
7V35 | B1 | Peptide | Glucagon | Glucagon | Homo sapiens | Peptide-20 | - | Gs/&β;1/&γ;2 | 3.5 | 2022-03-02 | 10.1038/s41467-022-28683-0 | |
8FU6 | B1 | Peptide | Glucagon | Glucagon | Homo sapiens | Glucagon derivative ZP3780 | - | Gs/&β;1/&γ;2 | 2.9 | 2023-04-12 | 10.1016/j.cell.2023.02.028 | |
8JIQ | B1 | Peptide | Glucagon | Glucagon | Homo sapiens | Peptide-15 | - | Gs/&β;1/&γ;2 | 3.4 | 2023-09-13 | 10.1073/pnas.2303696120 | |
8JIT | B1 | Peptide | Glucagon | Glucagon | Homo sapiens | MEDI0382 | - | Gs/&β;1/&γ;2 | 2.91 | 2023-09-06 | 10.1073/pnas.2303696120 | |
8JIU | B1 | Peptide | Glucagon | Glucagon | Homo sapiens | SAR425899 | - | Gs/&β;1/&γ;2 | 2.76 | 2023-09-13 | 10.1073/pnas.2303696120 | |
8WG8 | B1 | Peptide | Glucagon | Glucagon | Homo sapiens | - | Peptide | chim(NtGi1-Gs)/&β;1/&γ;2 | 2.71 | 2024-03-06 | 10.1038/s41421-024-00649-0 | |
7BW0 | A | Steroid | Bile acid | GPBA | Homo sapiens | - | - | chim(NtGi1-Gs)/&β;1/&γ;2 | 3.9 | 2020-09-02 | 10.1038/s41392-020-00262-z | |
7CFM | A | Steroid | Bile acid | GPBA | Homo sapiens | P395 | - | Gs/&β;1/&γ;2 | 3 | 2020-09-09 | 10.1038/s41586-020-2569-1 | |
7CFN | A | Steroid | Bile acid | GPBA | Homo sapiens | INT-777 | - | Gs/&β;1/&γ;2 | 3 | 2020-09-09 | 10.1038/s41586-020-2569-1 | |
7XTQ | A | Steroid | Bile acid | GPBA | Homo sapiens | R399 | - | Gs/&β;1/&γ;2 | 3.2 | 2022-07-06 | 10.1073/pnas.2117054119 | |
8XOG | A | Steroid | Estrogen | GPER1 | Homo sapiens | - | - | chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 | 2.9 | 2024-04-10 | To be published | |
8XOH | A | Steroid | Estrogen | GPER1 | Homo sapiens | - | - | chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 | 3.2 | 2024-04-10 | To be published | |
8XOI | A | Steroid | Estrogen | GPER1 | Homo sapiens | - | - | chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 | 3.2 | 2024-04-10 | To be published | |
8XOJ | A | Steroid | Estrogen | GPER1 | Homo sapiens | - | - | chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 | 3.1 | 2024-04-10 | To be published | |
8W8Q | A | Orphan | A orphans | GPR101 | Homo sapiens | - | - | Gs/&β;1/&γ;2 | 2.89 | 2024-01-03 | 10.1038/s41589-023-01456-6 | |
8W8R | A | Orphan | A orphans | GPR101 | Homo sapiens | - | AA-14 | chim(NtGi1-Gs)/&β;1/&γ;2 | 3.3 | 2024-01-03 | 10.1038/s41589-023-01456-6 | |
7WCM | A | Lipid | GPR119 | GPR119 | Homo sapiens | MBX-2982 | - | Gs/&β;1/&γ;2 | 2.33 | 2022-12-21 | 10.1038/s41467-022-34696-6 | |
7WCN | A | Lipid | GPR119 | GPR119 | Homo sapiens | AR231453 | - | Gs/&β;1/&γ;2 | 2.87 | 2022-12-21 | 10.1038/s41467-022-34696-6 | |
7XZ5 | A | Lipid | GPR119 | GPR119 | Homo sapiens | Lysophosphatidylcholine | - | Gs/&β;1/&γ;2 | 3.1 | 2022-08-24 | 10.1038/s41594-022-00816-5 | |
7XZ6 | A | Lipid | GPR119 | GPR119 | Homo sapiens | APD668 | - | Gs/&β;1/&γ;2 | 2.8 | 2022-08-24 | 10.1038/s41594-022-00816-5 | |
7Y3G | A | Orphan | A orphans | GPR12 | Homo sapiens | - | - | Gs/&β;1/&γ;2 | 2.77 | 2023-06-07 | 10.1016/j.scib.2022.12.023 | |
8HQE | A | Orphan | A orphans | GPR132 | Homo sapiens | - | - | Gi1/&β;1/&γ;2 | 2.97 | 2023-10-11 | 0.1038/s42255-023-00899-4 | |
8HQM | A | Orphan | A orphans | GPR132 | Homo sapiens | NPGLY | - | Gi1/&β;1/&γ;2 | 2.95 | 2023-10-11 | 0.1038/s42255-023-00899-4 | |
8HQN | A | Orphan | A orphans | GPR132 | Homo sapiens | 9(S)-HODE | - | Gi1/&β;1/&γ;2 | 3 | 2023-10-11 | 0.1038/s42255-023-00899-4 | |
8HVI | A | Orphan | A orphans | GPR132 | Homo sapiens | NOX-6-7 | - | Gi1/&β;1/&γ;2 | 3.04 | 2023-10-11 | 0.1038/s42255-023-00899-4 | |
7VUG | A | Orphan | A orphans | GPR139 | Homo sapiens | JNJ-63533054 | - | Gi1/&β;1/&γ;2 | 3.2 | 2021-12-29 | 10.1038/s41422-021-00591-w | |
7VUH | A | Orphan | A orphans | GPR139 | Homo sapiens | JNJ-63533054 | - | chim(Gs-CtGq)/&β;1/&γ;2 | 3.22 | 2021-12-29 | 10.1038/s41422-021-00591-w | |
7VUI | A | Orphan | A orphans | GPR139 | Homo sapiens | JNJ-63533054 | GTP | chim(Gs-CtGq)/&β;1/&γ;2 | 3.3 | 2021-12-29 | 10.1038/s41422-021-00591-w | |
7VUJ | A | Orphan | A orphans | GPR139 | Homo sapiens | JNJ-63533054 | GDP | chim(Gs-CtGq)/&β;1/&γ;2 | 3.8 | 2021-12-29 | 10.1038/s41422-021-00591-w | |
8KH4 | A | Orphan | A orphans | GPR161 | Homo sapiens | - | - | Gs/&β;1/&γ;2 | 3.1 | 2023-10-11 | 10.1038/s41467-023-41654-3 | |
8SMV | A | Orphan | A orphans | GPR161 | Homo sapiens | - | - | Gs/&β;1/&γ;2 | 2.74 | 2024-02-21 | 10.1038/s41594-024-01223-8 | |
7Y89 | A | Orphan | A orphans | GPR17 (CysLT) | Homo sapiens | - | - | Gi1/&β;1/&γ;2 | 3.02 | 2022-10-12 | 10.1002/mco2.159 | |
7XV3 | A | Orphan | A orphans | GPR174 | Homo sapiens | Lysophosphatidylserine | - | chim(NtGi1-Gs)/&β;1/&γ;2 | 2.76 | 2023-02-15 | 10.1038/s41467-023-36575-0 | |
8IZB | A | Orphan | A orphans | GPR174 | Homo sapiens | Lysophosphatidylserine | - | Gs/&β;1/&γ;2 | 3.06 | 2023-11-01 | 10.1371/journal.pbio.3002387 | |
8KH5 | A | Orphan | A orphans | GPR174 | Homo sapiens | Lysophosphatidylserine | - | Gs/&β;1/&γ;2 | 2.83 | 2023-10-11 | 10.1038/s41467-023-41654-3 | |
7TUZ | A | Orphan | A orphans | GPR183 | Homo sapiens | 7alpha,25-dihydroxycholesterol | - | Gi1/&β;1/&γ;2 | 3.12 | 2022-04-13 | 10.1016/j.str.2022.04.006 | |
8HS3 | A | Orphan | A orphans | GPR20 | Homo sapiens | - | - | Gi1/&β;1/&γ;2 | 3.14 | 2023-03-08 | 10.1038/s41421-023-00520-8 | |
8HSC | A | Orphan | A orphans | GPR20 | Homo sapiens | Fab046 | - | Gi1/&β;1/&γ;2 | 3.22 | 2023-03-08 | 10.1038/s41421-023-00520-8 | |
8HIX | A | Orphan | A orphans | GPR21 | Homo sapiens | - | - | Gs/&β;1/&γ;2 | 3.12 | 2023-03-15 | 10.1038/s41467-023-35882-w | |
8HJ0 | A | Orphan | A orphans | GPR21 | Homo sapiens | - | - | chim(Gs-CtG15)/&β;1/&γ;2 | 3.12 | 2023-03-15 | 10.1038/s41467-023-35882-w | |
8HJ1 | A | Orphan | A orphans | GPR21 | Homo sapiens | - | - | Gs/&β;1/&γ;2 | 3.27 | 2023-12-27 | 10.1038/s41467-023-35882-w | |
8HJ2 | A | Orphan | A orphans | GPR21 | Homo sapiens | - | - | chim(Gs-CtG15)/&β;1/&γ;2 | 3.8 | 2023-03-15 | 10.1038/s41467-023-35882-w | |
8HMV | A | Orphan | A orphans | GPR21 | Homo sapiens | - | - | Gs/&β;1/&γ;2 | 2.91 | 2023-03-01 | 10.1002/mco2.205 | |
8U8F | A | Orphan | A orphans | GPR3 | Homo sapiens | PML | - | Gs/&β;1/&γ;2 | 3.49 | 2024-03-06 | 10.1021/acs.biochem.3c00647 | |
8WW2 | A | Orphan | A orphans | GPR3 | Homo sapiens | - | - | chim(NtGi1-Gs)/&β;1/&γ;2 | 2.79 | 2024-02-14 | 10.1038/s41422-024-00932-5 | |
8X2K | A | Orphan | A orphans | GPR3 | Homo sapiens | 5YM | - | chim(NtGi1-Gs)/&β;1/&γ;2 | 3.03 | 2024-04-03 | To be published | |
8IZ4 | A | Orphan | A orphans | GPR34 | Homo sapiens | Lysophosphatidylserine | - | Gi1/&β;1/&γ;2 | 2.94 | 2024-04-10 | To be published | |
8K4N | A | Orphan | A orphans | GPR34 | Homo sapiens | VF0 | - | Gi1/&β;1/&γ;2 | 2.83 | 2023-10-25 | To be published | |
8SAI | A | Orphan | A orphans | GPR34 | Homo sapiens | 1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine | - | Gi1/&β;1/&γ;2 | 3.27 | 2023-10-04 | 10.1073/pnas.2308435120 | |
8WRB | A | Orphan | A orphans | GPR34 | Homo sapiens | Lysophosphatidylserine | - | Gi1/&β;1/&γ;2 | 2.91 | 2023-11-08 | 10.1371/journal.pbio.3002387 | |
8XBH | A | Orphan | A orphans | GPR34 | Homo sapiens | S3E-LysoPS | - | Gi1/&β;1/&γ;2 | 2.83 | 2023-12-27 | To be published | |
8H8J | A | Orphan | A orphans | GPR35 | Homo sapiens | Lodoxamide | Ca | chim(NtGi1L-G13)/&β;1/&γ;2 | 3.2 | 2023-02-08 | 10.1038/s41421-022-00499-8 | |
6LI3 | A | Orphan | A orphans | GPR52 | Homo sapiens | - | - | Gs/&β;1/&γ;2 | 3.32 | 2020-02-26 | 10.1038/s41586-020-2019-0 | |
8HMP | A | Orphan | A orphans | GPR52 | Homo sapiens | - | PubChem 69921479 | Gs/&β;1/&γ;2 | 2.77 | 2023-06-21 | 10.1002/mco2.260 | |
8KGK | A | Orphan | A orphans | GPR61 | Homo sapiens | - | - | Gs/&β;1/&γ;2 | 3.16 | 2023-10-11 | 10.1038/s41467-023-41654-3 | |
8TB0 | A | Orphan | A orphans | GPR61 | Homo sapiens | - | - | chim(NtGi1-Gs)/&β;1/&γ;2 | 3.47 | 2023-10-04 | 10.1038/s41467-023-41646-3 | |
8G05 | A | Orphan | A orphans | GPR84 | Homo sapiens | 6-OAU | - | Gi1/&β;1/&γ;2 | 3 | 2023-11-01 | 10.1038/s41467-023-41201-0 | |
8J18 | A | Orphan | A orphans | GPR84 | Homo sapiens | (3R)-3-hydroxydodecanoic acid | - | Gi1/&β;1/&γ;2 | 2.89 | 2023-06-21 | 10.1038/s41467-023-38985-6 | |
8J19 | A | Orphan | A orphans | GPR84 | Homo sapiens | PubChem 127045422 | - | Gi1/&β;1/&γ;2 | 3.23 | 2023-06-21 | 10.1038/s41467-023-38985-6 | |
8J1A | A | Orphan | A orphans | GPR84 | Homo sapiens | - | - | Gi1/&β;1/&γ;2 | 3.24 | 2023-06-21 | 10.1038/s41467-023-38985-6 | |
7EJX | A | Orphan | A orphans | GPR88 | Homo sapiens | - | (1R;2R)-2-PCCA | Gi1/&β;1/&γ;2 | 2.4 | 2022-04-13 | 10.1038/s41467-022-30081-5 | |
7WZ4 | A | Orphan | A orphans | GPR88 | Homo sapiens | - | - | Gi1/&β;1/&γ;2 | 3 | 2022-10-26 | 10.1038/s41467-022-30081-5 | |
7DFL | A | Amine | Histamine | H1 | Homo sapiens | Histamine | - | chim(NtGi1L-Gq)/&β;1/&γ;2 | 3.3 | 2021-03-31 | 10.1038/s41467-021-22427-2 | |
8POK | A | Amine | Histamine | H2 | Homo sapiens | Histamine | - | Gs/&β;1/&γ;2 | 3.4 | 2024-03-06 | 10.1038/s41467-024-46096-z | |
7YFC | A | Amine | Histamine | H4 | Homo sapiens | Histamine | - | chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 | 3 | 2023-10-25 | 10.1038/s41467-023-42260-z | |
7YFD | A | Amine | Histamine | H4 | Homo sapiens | Imetit | - | chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 | 3.1 | 2023-10-25 | 10.1038/s41467-023-42260-z | |
8HN8 | A | Amine | Histamine | H4 | Homo sapiens | Histamine | - | Gi1/&β;1/&γ;2 | 3 | 2023-12-20 | To be published | |
8HOC | A | Amine | Histamine | H4 | Homo sapiens | Imetit | - | Gi1/&β;1/&γ;2 | 3 | 2023-12-20 | To be published | |
8JXT | A | Amine | Histamine | H4 | Homo sapiens | Histamine | PO4 | Gi1/&β;1/&γ;2 | 3.07 | 2024-03-20 | 10.1038/s41467-024-46840-5 | |
8JXV | A | Amine | Histamine | H4 | Homo sapiens | Clozapine | - | Gi1/&β;1/&γ;2 | 3.21 | 2024-03-20 | 10.1038/s41467-024-46840-5 | |
8JXW | A | Amine | Histamine | H4 | Homo sapiens | VUF6884 | - | Gi1/&β;1/&γ;2 | 3.01 | 2024-03-20 | 10.1038/s41467-024-46840-5 | |
8JXX | A | Amine | Histamine | H4 | Homo sapiens | Clobenpropit | - | Gi1/&β;1/&γ;2 | 3.06 | 2024-03-20 | 10.1038/s41467-024-46840-5 | |
7XK2 | A | Alicarboxylic acid | Hydroxycarboxylic acid | HCA2 | Homo sapiens | MK6892 | - | Gi1/&β;1/&γ;2 | 3.1 | 2023-02-22 | 10.1038/s41467-023-37177-6 | |
8H2G | A | Alicarboxylic acid | Hydroxycarboxylic acid | HCA2 | Homo sapiens | Niacin | - | Gi1/&β;1/&γ;2 | 3.01 | 2023-10-11 | To be published | |
8I7V | A | Alicarboxylic acid | Hydroxycarboxylic acid | HCA2 | Homo sapiens | Acipimox | - | Gi1/&β;1/&γ;2 | 2.77 | 2024-02-07 | 10.1038/s41467-023-42764-8 | |
8I7W | A | Alicarboxylic acid | Hydroxycarboxylic acid | HCA2 | Homo sapiens | GSK256073 | - | Gi1/&β;1/&γ;2 | 3.39 | 2024-02-07 | 10.1038/s41467-023-42764-8 | |
8IHB | A | Alicarboxylic acid | Hydroxycarboxylic acid | HCA2 | Homo sapiens | GSK256073 | - | Gi1/&β;1/&γ;2 | 2.85 | 2023-09-13 | 10.1038/s41467-023-41650-7 | |
8IHF | A | Alicarboxylic acid | Hydroxycarboxylic acid | HCA2 | Homo sapiens | MK6892 | - | Gi1/&β;1/&γ;2 | 2.97 | 2023-08-30 | 10.1038/s41467-023-41650-7 | |
8IHH | A | Alicarboxylic acid | Hydroxycarboxylic acid | HCA2 | Homo sapiens | LUF6283 | - | Gi1/&β;1/&γ;2 | 3.06 | 2023-08-30 | 10.1038/s41467-023-41650-7 | |
8IHI | A | Alicarboxylic acid | Hydroxycarboxylic acid | HCA2 | Homo sapiens | Acifran | - | Gi1/&β;1/&γ;2 | 3.11 | 2023-08-30 | 10.1038/s41467-023-41650-7 | |
8IJ3 | A | Alicarboxylic acid | Hydroxycarboxylic acid | HCA2 | Homo sapiens | - | - | Gi1/&β;1/&γ;2 | 3.28 | 2024-01-03 | 10.1038/s41421-023-00610-7 | |
8IJA | A | Alicarboxylic acid | Hydroxycarboxylic acid | HCA2 | Homo sapiens | Niacin | - | Gi1/&β;1/&γ;2 | 2.69 | 2024-01-03 | 10.1038/s41421-023-00610-7 | |
8IJB | A | Alicarboxylic acid | Hydroxycarboxylic acid | HCA2 | Homo sapiens | Acipimox | - | Gi1/&β;1/&γ;2 | 3.23 | 2024-01-03 | 10.1038/s41421-023-00610-7 | |
8IJD | A | Alicarboxylic acid | Hydroxycarboxylic acid | HCA2 | Homo sapiens | MK6892 | - | Gi1/&β;1/&γ;2 | 3.25 | 2024-01-03 | 10.1038/s41421-023-00610-7 | |
8IY9 | A | Alicarboxylic acid | Hydroxycarboxylic acid | HCA2 | Homo sapiens | Niacin | - | Go/&β;1/&γ;2 | 3.37 | 2024-03-06 | 10.1038/s41467-024-46239-2 | |
8IYH | A | Alicarboxylic acid | Hydroxycarboxylic acid | HCA2 | Homo sapiens | MK6892 | - | Go/&β;1/&γ;2 | 3.3 | 2024-03-06 | 10.1038/s41467-024-46239-2 | |
8IYW | A | Alicarboxylic acid | Hydroxycarboxylic acid | HCA2 | Homo sapiens | GSK256073 | - | Go/&β;1/&γ;2 | 3.45 | 2024-03-06 | 10.1038/s41467-024-46239-2 | |
8J6I | A | Alicarboxylic acid | Hydroxycarboxylic acid | HCA2 | Homo sapiens | MK6892 | - | Gi1/&β;1/&γ;2 | 2.92 | 2024-04-03 | 10.1016/j.celrep.2023.113406 | |
8J6J | A | Alicarboxylic acid | Hydroxycarboxylic acid | HCA2 | Homo sapiens | GSK256073 | - | Gi1/&β;1/&γ;2 | 2.8 | 2024-01-10 | 10.1016/j.celrep.2023.113406 | |
8J6L | A | Alicarboxylic acid | Hydroxycarboxylic acid | HCA2 | Homo sapiens | Niacin | - | Gi1/&β;1/&γ;2 | 3.05 | 2024-04-03 | 10.1016/j.celrep.2023.113406 | |
8J6P | A | Alicarboxylic acid | Hydroxycarboxylic acid | HCA2 | Homo sapiens | Niacin | Compound 9n | Gi1/&β;1/&γ;2 | 2.55 | 2023-12-06 | 10.1038/s41467-023-43537-z | |
8J6Q | A | Alicarboxylic acid | Hydroxycarboxylic acid | HCA2 | Homo sapiens | Beta-hydroxybutyrate | Compound 9n | Gi1/&β;1/&γ;2 | 2.6 | 2023-12-06 | 10.1038/s41467-023-43537-z | |
8J6R | A | Alicarboxylic acid | Hydroxycarboxylic acid | HCA2 | Homo sapiens | MK6892 | - | Gi1/&β;1/&γ;2 | 2.76 | 2023-12-06 | 10.1038/s41467-023-43537-z | |
8JER | A | Alicarboxylic acid | Hydroxycarboxylic acid | HCA2 | Homo sapiens | Acipimox | - | Go/&β;1/&γ;2 | 3.45 | 2024-03-06 | 10.1038/s41467-024-46239-2 | |
8JHN | A | Alicarboxylic acid | Hydroxycarboxylic acid | HCA2 | Homo sapiens | MMF | - | Go/&β;1/&γ;2 | 3.75 | 2024-03-06 | 10.1038/s41467-024-46239-2 | |
8JHY | A | Alicarboxylic acid | Hydroxycarboxylic acid | HCA2 | Homo sapiens | - | Compound 9n | Gi1/&β;1/&γ;2 | 2.87 | 2023-09-06 | 10.1016/j.molcel.2023.07.030 | |
8JII | A | Alicarboxylic acid | Hydroxycarboxylic acid | HCA2 | Homo sapiens | Niacin | Compound 9n | Gi1/&β;1/&γ;2 | 3.17 | 2023-09-06 | 10.1016/j.molcel.2023.07.030 | |
8JIL | A | Alicarboxylic acid | Hydroxycarboxylic acid | HCA2 | Homo sapiens | Niacin | - | Gi1/&β;1/&γ;2 | 3.5 | 2023-09-06 | 10.1016/j.molcel.2023.07.030 | |
8JIM | A | Alicarboxylic acid | Hydroxycarboxylic acid | HCA2 | Homo sapiens | MMF | - | Gi1/&β;1/&γ;2 | 2.98 | 2023-09-06 | 10.1016/j.molcel.2023.07.030 | |
8JZ7 | A | Alicarboxylic acid | Hydroxycarboxylic acid | HCA2 | Homo sapiens | MK6892 | - | Gi1/&β;1/&γ;2 | 2.6 | 2023-10-04 | 10.1038/s41392-023-01625-y | |
8IHJ | A | Alicarboxylic acid | Hydroxycarboxylic acid | HCA3 | Homo sapiens | Acifran | - | Gi1/&β;1/&γ;2 | 3.07 | 2023-08-30 | 10.1038/s41467-023-41650-7 | |
8X79 | A | Lipid | Prostanoid | I2 | Homo sapiens | MRE-269 | - | Gs/&β;1/&γ;2 | 2.41 | 2024-03-06 | 10.1126/sciadv.adk5184 | |
8X7A | A | Lipid | Prostanoid | I2 | Homo sapiens | Treprostinil | - | Gs/&β;1/&γ;2 | 2.56 | 2024-03-06 | 10.1126/sciadv.adk5184 | |
7Y1F | A | Peptide | Opioid | κ | Homo sapiens | Dynorphin | - | Gi1/&β;1/&γ;2 | 3.3 | 2023-05-24 | 10.1093/procel/pwac033 | |
8DZP | A | Peptide | Opioid | κ | Homo sapiens | momSalB | - | Gi1/&β;1/&γ;2 | 2.71 | 2023-05-03 | 10.1038/s41586-023-06030-7 | |
8DZQ | A | Peptide | Opioid | κ | Homo sapiens | momSalB | - | Go/&β;1/&γ;2 | 2.82 | 2023-05-03 | 10.1038/s41586-023-06030-7 | |
8DZR | A | Peptide | Opioid | κ | Homo sapiens | GR89,696 | - | chim(NtGi2-Gt3)/&β;1/&γ;2 | 2.61 | 2023-05-03 | 10.1038/s41586-023-06030-7 | |
8DZS | A | Peptide | Opioid | κ | Homo sapiens | GR89,696 | - | chim(NtGi2-Gz)/&β;1/&γ;2 | 2.65 | 2023-05-03 | 10.1038/s41586-023-06030-7 | |
8F7W | A | Peptide | Opioid | κ | Homo sapiens | Dynorphin | - | Gi1/&β;1/&γ;2 | 3.19 | 2022-12-14 | 10.1016/j.cell.2022.12.026 | |
8FEG | A | Peptide | Opioid | κ | Homo sapiens | PRD_002517 | - | Gi1/&β;1/&γ;2 | 2.54 | 2023-12-06 | 10.1038/s41467-023-43718-w | |
7FIG | A | Protein | Glycoprotein hormone | LH | Homo sapiens | hCG | - | chim(NtGi1L-Gs)/&β;1/&γ;2 | 3.9 | 2021-09-29 | 10.1038/s41586-021-03924-2 | |
7FIH | A | Protein | Glycoprotein hormone | LH | Homo sapiens | hCG | Org43553 | chim(NtGi1-Gs)/&β;1/&γ;2 | 3.2 | 2021-09-29 | 10.1038/s41586-021-03924-2 | |
7TD0 | A | Lipid | Lysophospholipid (LPA) | LPA1 | Homo sapiens | LPA | - | Gi1/&β;1/&γ;2 | 2.83 | 2022-02-09 | 10.1038/s41467-022-28417-2 | |
7TD1 | A | Lipid | Lysophospholipid (LPA) | LPA1 | Homo sapiens | LPA | - | Gi1/&β;1/&γ;2 | 3.08 | 2022-02-09 | 10.1038/s41467-022-28417-2 | |
7TD2 | A | Lipid | Lysophospholipid (LPA) | LPA1 | Homo sapiens | LPA | - | Gi1/&β;1/&γ;2 | 3.11 | 2022-02-09 | 10.1038/s41467-022-28417-2 | |
7YU3 | A | Lipid | Lysophospholipid (LPA) | LPA1 | Homo sapiens | ONO-0740556 | - | Gi1/&β;1/&γ;2 | 3.5 | 2022-10-05 | 10.1038/s41467-022-33121-2 | |
7YU5 | A | Lipid | Lysophospholipid (LPA) | LPA1 | Homo sapiens | ONO-0740556 | - | Gi1/&β;1/&γ;2 | 3.7 | 2022-10-05 | 10.1038/s41467-022-33121-2 | |
7YU6 | A | Lipid | Lysophospholipid (LPA) | LPA1 | Homo sapiens | ONO-0740556 | - | Gi1/&β;1/&γ;2 | 3.9 | 2022-10-05 | 10.1038/s41467-022-33121-2 | |
7YU7 | A | Lipid | Lysophospholipid (LPA) | LPA1 | Homo sapiens | ONO-0740556 | - | Gi1/&β;1/&γ;2 | 4.5 | 2022-10-05 | 10.1038/s41467-022-33121-2 | |
7YU8 | A | Lipid | Lysophospholipid (LPA) | LPA1 | Homo sapiens | ONO-0740556 | - | Gi1/&β;1/&γ;2 | 5.6 | 2022-10-05 | 10.1038/s41467-022-33121-2 | |
6OIJ | A | Amine | Acetylcholine (muscarinic) | M1 | Homo sapiens | Iperoxo | - | chim(NtGi1L-G11)/&β;1/&γ;2 | 3.3 | 2019-05-08 | 10.1126/science.aaw5188 | |
6OIK | A | Amine | Acetylcholine (muscarinic) | M2 | Homo sapiens | Iperoxo | LY2119620 | chim(NtGi1-Go)/&β;1/&γ;2 | 3.6 | 2019-05-08 | 10.1126/science.aaw5188 | |
7T8X | A | Amine | Acetylcholine (muscarinic) | M2 | Homo sapiens | Acetylcholine | - | chim(NtGi1-Go)/&β;1/&γ;2 | 3.21 | 2023-01-25 | 10.1038/s41467-022-35726-z | |
7T90 | A | Amine | Acetylcholine (muscarinic) | M2 | Homo sapiens | Acetylcholine | - | chim(NtGi1-Go)/&β;1/&γ;2 | 3.32 | 2023-01-25 | 10.1038/s41467-022-35726-z | |
7T94 | A | Amine | Acetylcholine (muscarinic) | M2 | Homo sapiens | Acetylcholine | PubChem 57664406 | chim(NtGi1-Go)/&β;1/&γ;2 | 3.16 | 2023-01-25 | 10.1038/s41467-022-35726-z | |
8E9W | A | Amine | Acetylcholine (muscarinic) | M3 | Homo sapiens | 2-Deoxycytidine | - | chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 | 2.69 | 2022-11-30 | 10.1038/s41586-022-05489-0 | |
8E9Y | A | Amine | Acetylcholine (muscarinic) | M3 | Homo sapiens | PubChem 446603 | - | chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 | 2.79 | 2022-11-30 | 10.1038/s41586-022-05489-0 | |
8E9Z | A | Amine | Acetylcholine (muscarinic) | M3 | Homo sapiens | Iperoxo | - | chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 | 2.69 | 2022-11-30 | 10.1038/s41586-022-05489-0 | |
7TRK | A | Amine | Acetylcholine (muscarinic) | M4 | Homo sapiens | Iperoxo | - | Gi1/&β;1/&γ;2 | 2.8 | 2023-05-17 | 10.2139/ssrn.4034884 | |
7TRP | A | Amine | Acetylcholine (muscarinic) | M4 | Homo sapiens | Iperoxo | LY2033298 | Gi1/&β;1/&γ;2 | 2.4 | 2023-05-17 | 10.2139/ssrn.4034884 | |
7TRQ | A | Amine | Acetylcholine (muscarinic) | M4 | Homo sapiens | Iperoxo | VU0467154 | Gi1/&β;1/&γ;2 | 2.5 | 2023-05-17 | 10.2139/ssrn.4034884 | |
7TRS | A | Amine | Acetylcholine (muscarinic) | M4 | Homo sapiens | Acetylcholine | - | Gi1/&β;1/&γ;2 | 2.8 | 2023-05-17 | 10.2139/ssrn.4034884 | |
7V68 | A | Amine | Acetylcholine (muscarinic) | M4 | Homo sapiens | Iperoxo | PubChem 57664406 | Gi1/&β;1/&γ;2 | 3.4 | 2022-05-11 | 10.1038/s41467-022-30595-y | |
7V69 | A | Amine | Acetylcholine (muscarinic) | M4 | Homo sapiens | - | - | Gi1/&β;1/&γ;2 | 3.4 | 2022-05-11 | 10.1038/s41467-022-30595-y | |
7V6A | A | Amine | Acetylcholine (muscarinic) | M4 | Homo sapiens | PubChem 9864275 | - | Gi1/&β;1/&γ;2 | 3.6 | 2022-05-11 | 10.1038/s41467-022-30595-y | |
8E9X | A | Amine | Acetylcholine (muscarinic) | M4 | Homo sapiens | 2-Deoxycytidine | - | chim(NtGi1-Go)/&β;1/&γ;2 | 2.7 | 2022-11-30 | 10.1038/s41586-022-05489-0 | |
8FX5 | A | Amine | Acetylcholine (muscarinic) | M4 | Homo sapiens | Xanomeline | Xanomeline | Gi1/&β;1/&γ;2 | 2.45 | 2023-09-13 | 10.1038/s41467-023-41199-5 | |
7F4D | A | Peptide | Melanocortin | MC1 | Homo sapiens | Alpha-MSH | - | chim(NtGi1-Gs)/&β;1/&γ;2 | 3 | 2021-09-08 | 10.1038/s41422-021-00557-y | |
7F4F | A | Peptide | Melanocortin | MC1 | Homo sapiens | Afamelanotide | - | chim(NtGi1-Gs)/&β;1/&γ;2 | 2.9 | 2021-09-08 | 10.1038/s41422-021-00557-y | |
7F4H | A | Peptide | Melanocortin | MC1 | Homo sapiens | Afamelanotide | - | chim(NtGi1-Gs)/&β;1/&γ;2 | 2.7 | 2021-09-08 | 10.1038/s41422-021-00557-y | |
7F4I | A | Peptide | Melanocortin | MC1 | Homo sapiens | SHU9119 | - | chim(NtGi1-Gs)/&β;1/&γ;2 | 3.1 | 2021-09-08 | 10.1038/s41422-021-00557-y | |
8GY7 | A | Peptide | Melanocortin | MC2 | Homo sapiens | Corticotropin | Ca | chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1 | 3.3 | 2023-01-11 | 10.1038/s41422-022-00751-6 | |
8IOC | A | Peptide | Melanocortin | MC3 | Homo sapiens | Gamma-MSH | Ca | chim(NtGi1-Gs)/&β;1/&γ;2 | 2.86 | 2023-09-20 | 10.1038/s41421-023-00586-4 | |
7AUE | A | Peptide | Melanocortin | MC4 | Homo sapiens | Setmelanotide | - | chim(NtGi1L-Gs)/&β;1/&γ;2 | 2.97 | 2021-04-28 | 10.1126/science.abf7958 | |
7F53 | A | Peptide | Melanocortin | MC4 | Homo sapiens | Alpha-MSH | - | Gs/&β;1/&γ;2 | 3 | 2021-11-03 | 10.1038/s41422-021-00552-3 | |
7F54 | A | Peptide | Melanocortin | MC4 | Homo sapiens | Afamelanotide | - | Gs/&β;1/&γ;2 | 3 | 2021-11-03 | 10.1038/s41422-021-00552-3 | |
7F55 | A | Peptide | Melanocortin | MC4 | Homo sapiens | Bremelanotide | - | Gs/&β;1/&γ;2 | 3.1 | 2021-11-03 | 10.1038/s41422-021-00552-3 | |
7F58 | A | Peptide | Melanocortin | MC4 | Homo sapiens | THIQ | - | Gs/&β;1/&γ;2 | 3.1 | 2021-11-03 | 10.1038/s41422-021-00552-3 | |
7PIU | A | Peptide | Melanocortin | MC4 | Homo sapiens | Setmelanotide | - | Gs/&β;1/&γ;2 | 2.58 | 2021-11-17 | 10.1038/s41422-021-00569-8 | |
7PIV | A | Peptide | Melanocortin | MC4 | Homo sapiens | Setmelanotide | - | Gs/&β;1/&γ;2 | 2.86 | 2021-11-17 | 10.1038/s41422-021-00569-8 | |
8INR | A | Peptide | Melanocortin | MC5 | Homo sapiens | Alpha-MSH | Ca | chim(NtGi1-Gs)/&β;1/&γ;2 | 2.73 | 2023-09-20 | 10.1038/s41421-023-00586-4 | |
8IOD | A | Peptide | Melanocortin | MC5 | Homo sapiens | PG-901 | Ca | chim(NtGi1-Gs)/&β;1/&γ;2 | 2.59 | 2023-09-20 | 10.1038/s41421-023-00586-4 | |
7E9G | C | Aminoacid | Metabotropic glutamate | mGlu2; mGlu2 | Homo sapiens | Eglumetad | JNJ-40411813 | Gi1/&β;1/&γ;2 | 3.5 | 2021-06-23 | 10.1038/s41586-021-03495-2 | |
7MTS | C | Aminoacid | Metabotropic glutamate | mGlu2; mGlu2 | Homo sapiens | Glutamate | ADX55164 | Gi1/&β;1/&γ;2 | 3.2 | 2021-07-07 | 10.1038/s41586-021-03680-3 | |
8JD3 | C | Aminoacid | Metabotropic glutamate | mGlu2; mGlu3 | Homo sapiens | Glutamate | HZR; PEF | Gi1/&β;1/&γ;2 | 3.3 | 2023-06-21 | 10.1038/s41422-023-00830-2 | |
8JD5 | C | Aminoacid | Metabotropic glutamate | mGlu2; mGlu4 | Homo sapiens | Glutamate | BQI; HZE; PEF | Gi1/&β;1/&γ;2 | 3.6 | 2023-06-21 | 10.1038/s41422-023-00830-2 | |
7E9H | C | Aminoacid | Metabotropic glutamate | mGlu4; mGlu4 | Homo sapiens | Phosphoserine | - | Gi3/&β;1/&γ;2 | 4 | 2021-06-23 | 10.1038/s41586-021-03495-2 | |
8JD6 | C | Aminoacid | Metabotropic glutamate | mGlu4; mGlu4 | Homo sapiens | Phosphoserine | N-(3-chlorophenyl)pyridine-2-carboxamide | Gi3/&β;1/&γ;2 | 3.4 | 2023-06-21 | 10.1038/s41422-023-00830-2 | |
6DDE | A | Peptide | Opioid | μ | Mus musculus | Damgo | - | Gi1/&β;1/&γ;2 | 3.5 | 2018-06-13 | 10.1038/s41586-018-0219-7 | |
6DDF | A | Peptide | Opioid | μ | Mus musculus | Damgo | - | Gi1/&β;1/&γ;2 | 3.5 | 2018-06-13 | 10.1038/s41586-018-0219-7 | |
7SBF | A | Peptide | Opioid | μ | Mus musculus | PZM21 | - | Gi1/&β;1/&γ;2 | 2.9 | 2022-04-20 | 10.1002/anie.202200269 | |
7SCG | A | Peptide | Opioid | μ | Mus musculus | FH210 | - | Gi1/&β;1/&γ;2 | 3 | 2022-04-20 | 10.1002/anie.202200269 | |
7T2G | A | Peptide | Opioid | μ | Mus musculus | Mitragynine pseudoindoxyl | - | Gi1/&β;1/&γ;2 | 2.5 | 2022-12-07 | 10.1038/s41589-022-01208-y | |
7T2H | A | Peptide | Opioid | μ | Mus musculus | Lofentanil | - | Gi1/&β;1/&γ;2 | 2.5 | 2022-12-07 | 10.1038/s41589-022-01208-y | |
7U2K | A | Peptide | Opioid | μ | Mus musculus | C6-guano | - | Gi1/&β;1/&γ;2 | 3.3 | 2022-12-07 | 10.1038/s41586-022-05588-y | |
7U2L | A | Peptide | Opioid | μ | Mus musculus | PubChem 163201242 | - | Gi1/&β;1/&γ;2 | 3.2 | 2022-05-04 | 10.1038/s41586-022-05588-y | |
8EF5 | A | Peptide | Opioid | μ | Homo sapiens | Fentanyl | - | Gi1/&β;1/&γ;2 | 3.3 | 2022-11-09 | 10.1016/j.cell.2022.09.041 | |
8EF6 | A | Peptide | Opioid | μ | Homo sapiens | Morphine | - | Gi1/&β;1/&γ;2 | 3.2 | 2022-11-09 | 10.1016/j.cell.2022.09.041 | |
8EFB | A | Peptide | Opioid | μ | Homo sapiens | Oliceridine | - | Gi1/&β;1/&γ;2 | 3.2 | 2022-11-09 | 10.1016/j.cell.2022.09.041 | |
8EFL | A | Peptide | Opioid | μ | Homo sapiens | SR17018 | - | Gi1/&β;1/&γ;2 | 3.2 | 2022-11-09 | 10.1016/j.cell.2022.09.041 | |
8EFO | A | Peptide | Opioid | μ | Homo sapiens | PZM21 | - | Gi1/&β;1/&γ;2 | 2.8 | 2022-11-09 | 10.1016/j.cell.2022.09.041 | |
8EFQ | A | Peptide | Opioid | μ | Homo sapiens | Damgo | - | Gi1/&β;1/&γ;2 | 3.3 | 2022-11-09 | 10.1016/j.cell.2022.09.041 | |
8F7Q | A | Peptide | Opioid | μ | Homo sapiens | Beta-endorphin | - | Gi1/&β;1/&γ;2 | 3.22 | 2022-12-14 | 10.1016/j.cell.2022.12.026 | |
8F7R | A | Peptide | Opioid | μ | Homo sapiens | Endomorphin | - | Gi1/&β;1/&γ;2 | 3.28 | 2022-12-14 | 10.1016/j.cell.2022.12.026 | |
8IBU | A | Peptide | Motilin | Motilin | Homo sapiens | Erythromycin A | - | chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 | 3.51 | 2023-04-12 | 10.1126/sciadv.ade9020 | |
8IBV | A | Peptide | Motilin | Motilin | Homo sapiens | Motilin | - | chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 | 3.19 | 2023-04-12 | 10.1126/sciadv.ade9020 | |
7Y12 | A | Orphan | A orphans | MRGPRD | Homo sapiens | Beta-alanine | - | Gi1/&β;1/&γ;2 | 3.1 | 2022-07-20 | 10.1038/s42003-022-03668-3 | |
7Y15 | A | Orphan | A orphans | MRGPRD | Homo sapiens | - | - | Gi1/&β;1/&γ;2 | 2.9 | 2022-07-20 | 10.1038/s42003-022-03668-3 | |
8DWC | A | Orphan | A orphans | MRGPRX1 | Homo sapiens | Proenkephalin-A | - | chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 | 2.87 | 2022-11-02 | 10.1038/s41589-022-01173-6 | |
8DWG | A | Orphan | A orphans | MRGPRX1 | Homo sapiens | Proenkephalin-A | ML382 | chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 | 2.71 | 2022-11-02 | 10.1038/s41589-022-01173-6 | |
8DWH | A | Orphan | A orphans | MRGPRX1 | Homo sapiens | Compound-16 | - | chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 | 3.25 | 2022-11-02 | 10.1038/s41589-022-01173-6 | |
8HJ5 | A | Orphan | A orphans | MRGPRX1 | Homo sapiens | PubChem 139030531 | - | chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 | 3 | 2023-05-31 | 10.1371/journal.pbio.3001975 | |
8JGB | A | Orphan | A orphans | MRGPRX1 | Homo sapiens | Conorfamide-Tx2 | - | Gi1/&β;1/&γ;2 | 2.84 | 2024-01-10 | 10.1038/s41467-023-40705-z | |
8JGF | A | Orphan | A orphans | MRGPRX1 | Homo sapiens | BAM8-22 | - | chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 | 2.7 | 2024-01-10 | 10.1038/s41467-023-40705-z | |
8JGG | A | Orphan | A orphans | MRGPRX1 | Homo sapiens | BAM8-22 | - | Gi1/&β;1/&γ;2 | 3 | 2024-01-10 | 10.1038/s41467-023-40705-z | |
7S8L | A | Orphan | A orphans | MRGPRX2 | Homo sapiens | Cortistatin-14 | - | chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 | 2.45 | 2021-11-17 | 10.1038/s41586-021-04126-6 | |
7S8M | A | Orphan | A orphans | MRGPRX2 | Homo sapiens | Cortistatin-14 | - | Gi1/&β;1/&γ;2 | 2.54 | 2021-11-17 | 10.1038/s41586-021-04126-6 | |
7S8N | A | Orphan | A orphans | MRGPRX2 | Homo sapiens | (R)-Zinc-3573 | - | chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 | 2.9 | 2021-11-17 | 10.1038/s41586-021-04126-6 | |
7S8O | A | Orphan | A orphans | MRGPRX2 | Homo sapiens | (R)-Zinc-3573 | - | Gi1/&β;1/&γ;2 | 2.58 | 2021-11-17 | 10.1038/s41586-021-04126-6 | |
7VDH | A | Orphan | A orphans | MRGPRX2 | Homo sapiens | C48/80 | - | Gi1/&β;1/&γ;2 | 2.9 | 2021-12-01 | 10.1038/s41586-021-04077-y | |
7VDL | A | Orphan | A orphans | MRGPRX2 | Homo sapiens | Cortistatin-14 | - | Gi1/&β;1/&γ;2 | 3.22 | 2021-12-01 | 10.1038/s41586-021-04077-y | |
7VDM | A | Orphan | A orphans | MRGPRX2 | Homo sapiens | Substance P | - | Gi1/&β;1/&γ;2 | 2.98 | 2021-12-01 | 10.1038/s41586-021-04077-y | |
7VUY | A | Orphan | A orphans | MRGPRX2 | Homo sapiens | - | - | Gi1/&β;1/&γ;2 | 2.84 | 2021-12-01 | 10.1038/s41586-021-04077-y | |
7VUZ | A | Orphan | A orphans | MRGPRX2 | Homo sapiens | - | - | Gi1/&β;1/&γ;2 | 2.89 | 2021-12-01 | 10.1038/s41586-021-04077-y | |
7VV3 | A | Orphan | A orphans | MRGPRX2 | Homo sapiens | - | - | Gi1/&β;1/&γ;2 | 2.97 | 2021-12-01 | 10.1038/s41586-021-04077-y | |
7VV5 | A | Orphan | A orphans | MRGPRX2 | Homo sapiens | C48/80 | - | Gi1/&β;1/&γ;2 | 2.76 | 2021-12-01 | 10.1038/s41586-021-04077-y | |
7S8P | A | Orphan | A orphans | MRGPRX4 | Homo sapiens | MS47134 | - | chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 | 2.6 | 2021-11-17 | 10.1038/s41586-021-04126-6 | |
7DB6 | A | Melatonin | Melatonin | MT1 | Homo sapiens | Ramelteon | - | Gi1/&β;1/&γ;2 | 3.3 | 2021-08-18 | 10.1038/s41594-021-00634-1 | |
7VGY | A | Melatonin | Melatonin | MT1 | Homo sapiens | 2-Iodomelatonin | - | Gi1/&β;1/&γ;2 | 3.1 | 2022-03-02 | 10.1038/s41467-022-28111-3 | |
7VGZ | A | Melatonin | Melatonin | MT1 | Homo sapiens | Remalteon | - | Gi1/&β;1/&γ;2 | 3.3 | 2022-03-02 | 10.1038/s41467-022-28111-3 | |
7VH0 | A | Melatonin | Melatonin | MT2 | Homo sapiens | Ramelteon | - | Gi1/&β;1/&γ;1 | 3.46 | 2022-03-02 | 10.1038/s41467-022-28111-3 | |
7P00 | A | Peptide | Tachykinin | NK1 | Homo sapiens | Substance P | - | chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 | 2.71 | 2021-12-15 | 10.1126/sciadv.abk2872 | |
7P02 | A | Peptide | Tachykinin | NK1 | Homo sapiens | Protachykinin-1 | - | chim(NtGi1-Gs)/&β;1/&γ;2 | 2.87 | 2021-12-15 | 10.1126/sciadv.abk2872 | |
7RMG | A | Peptide | Tachykinin | NK1 | Homo sapiens | Substance P | - | chim(Gs-CtGq)/&β;1/&γ;2 | 3 | 2021-11-03 | 10.1038/s41589-021-00890-8 | |
7RMH | A | Peptide | Tachykinin | NK1 | Homo sapiens | Substance P | - | Gs/&β;1/&γ;2 | 3.1 | 2021-11-03 | 10.1038/s41589-021-00890-8 | |
7RMI | A | Peptide | Tachykinin | NK1 | Homo sapiens | Substance P | - | chim(Gs-CtGq)/&β;1/&γ;2 | 3.2 | 2021-11-03 | 10.1038/s41589-021-00890-8 | |
8U26 | A | Peptide | Tachykinin | NK1 | Homo sapiens | Protachykinin-1 | - | Gs/&β;1/&γ;2 | 2.5 | 2023-11-15 | 10.1038/s41592-023-02082-9 | |
7XWO | A | Peptide | Tachykinin | NK2 | Homo sapiens | Neurokinin-A | - | chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 | 2.7 | 2023-05-31 | 10.1038/s41421-022-00437-8 | |
8JBF | A | Peptide | Tachykinin | NK3 | Homo sapiens | Senktide | - | chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 | 3 | 2024-02-28 | 10.1038/s41421-023-00564-w | |
7W53 | A | Peptide | Neuromedin U | NMUR1 | Homo sapiens | Neuromedin-U-25 | - | chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 | 3.2 | 2022-04-20 | 10.1038/s41467-022-29683-w | |
7W56 | A | Peptide | Neuromedin U | NMUR1 | Homo sapiens | Neuromedin-S | - | chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 | 2.9 | 2022-04-20 | 10.1038/s41467-022-29683-w | |
7W55 | A | Peptide | Neuromedin U | NMUR2 | Homo sapiens | Neuromedin-U-25 | - | chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 | 2.8 | 2022-04-20 | 10.1038/s41467-022-29683-w | |
7W57 | A | Peptide | Neuromedin U | NMUR2 | Homo sapiens | Neuromedin-S | - | chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 | 3.2 | 2022-04-20 | 10.1038/s41467-022-29683-w | |
7XK8 | A | Peptide | Neuromedin U | NMUR2 | Homo sapiens | Neuromedin-U-25 | - | Gi1/&β;1/&γ;2 | 3.3 | 2023-02-22 | 10.1038/s41467-022-34814-4 | |
8F7X | A | Peptide | Opioid | NOP | Homo sapiens | Nociceptin | - | Gi1/&β;1/&γ;2 | 3.28 | 2022-12-14 | 10.1016/j.cell.2022.12.026 | |
6OS9 | A | Peptide | Neurotensin | NTS1 | Homo sapiens | JMV449 | - | Gi1/&β;1/&γ;2 | 3 | 2019-07-10 | 10.1038/s41586-019-1337-6 | |
6OSA | A | Peptide | Neurotensin | NTS1 | Homo sapiens | JMV449 | - | Gi1/&β;1/&γ;2 | 3 | 2019-07-10 | 10.1038/s41586-019-1337-6 | |
7L0P | A | Peptide | Neurotensin | NTS1 | Rattus norvegicus | Neurotensin | - | Gi1/&β;1/&γ;1 | 4.1 | 2021-01-06 | 10.1038/s41594-020-00554-6 | |
7L0Q | A | Peptide | Neurotensin | NTS1 | Rattus norvegicus | Neurotensin | - | Gi1/&β;1/&γ;1 | 4.3 | 2021-01-06 | 10.1038/s41594-020-00554-6 | |
7L0R | A | Peptide | Neurotensin | NTS1 | Rattus norvegicus | Neurotensin | - | Gi1/&β;1/&γ;1 | 4.2 | 2021-01-06 | 10.1038/s41594-020-00554-6 | |
7L0S | A | Peptide | Neurotensin | NTS1 | Rattus norvegicus | Neurotensin | - | Gi1/&β;1/γ1 | 4.5 | 2021-01-06 | 10.1038/s41594-020-00554-6 | |
8FMZ | A | Peptide | Neurotensin | NTS1 | Rattus norvegicus | Neurotensin/neuromedin N | - | chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 | 2.59 | 2023-03-29 | 10.1021/acs.biochem.3c00029 | |
8FN0 | A | Peptide | Neurotensin | NTS1 | Rattus norvegicus | Neurotensin/neuromedin N | PubChem 118610427 | chim(NtGi1-Go)/&β;1/&γ;2 | 2.89 | 2023-03-29 | 10.1021/acs.biochem.3c00029 | |
8FN1 | A | Peptide | Neurotensin | NTS1 | Rattus norvegicus | Neurotensin/neuromedin N | - | chim(NtGi1-Go)/&β;1/&γ;2 | 2.88 | 2023-03-29 | 10.1021/acs.biochem.3c00029 | |
8JPB | A | Peptide | Neurotensin | NTS1 | Homo sapiens | Neurotensin 8-13 | PubChem 118610427; GDP; Mg | Gq; GRK2 | 3.07 | 2023-08-09 | 10.1038/s41586-023-06395-9 | |
8JPC | A | Peptide | Neurotensin | NTS1 | Homo sapiens | Neurotensin 8-13 | PubChem 118610427; GDP; Mg | Gq; GRK2 | 3.07 | 2023-08-09 | 10.1038/s41586-023-06395-9 | |
8IU2 | A | Sensory | Opsins | Opsin1LW | Homo sapiens | Retinal | - | Gi1/&β;1/&γ;2 | 3.35 | 2024-03-27 | To be published | |
8F76 | A | Olfactory receptors | Olfactory | OR51E2 | Homo sapiens | - | - | Gs/&β;1/&γ;2 | 3.1 | 2023-03-22 | 10.1038/s41586-023-05798-y | |
8HTI | A | Olfactory receptors | Olfactory | OR52C | Homo sapiens | Ocatnoic Acid | - | Gs/&β;1/&γ;2 | 2.97 | 2023-12-20 | 10.1038/s41467-023-43983-9 | |
7QVM | A | Peptide | Vasopressin and oxytocin | OT | Homo sapiens | Oxytocin | - | chim(NtGi1-Go-CtGq)/&β;1/&γ;2 | 3.25 | 2022-08-10 | 10.1038/s41467-022-31325-0 | |
7RYC | A | Peptide | Vasopressin and oxytocin | OT | Homo sapiens | Oxytocin | - | chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 | 2.9 | 2022-03-09 | 10.1038/s41594-022-00728-4 | |
7L1U | A | Peptide | Orexin | OX2 | Homo sapiens | Orexin | - | chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 | 3.2 | 2021-02-10 | 10.1038/s41467-021-21087-6 | |
7L1V | A | Peptide | Orexin | OX2 | Homo sapiens | PubChem 155491009 | - | chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 | 3 | 2021-02-10 | 10.1038/s41467-021-21087-6 | |
7SQO | A | Peptide | Orexin | OX2 | Homo sapiens | TAK-925 | - | Gi1/&β;1/&γ;2 | 3.17 | 2022-05-25 | 10.1038/s41467-022-30601-3 | |
7SR8 | A | Peptide | Orexin | OX2 | Homo sapiens | TAK-925 | - | chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 | 3.3 | 2022-06-08 | 10.1038/s41467-022-30601-3 | |
7XXH | A | Nucleotide | P2Y | P2Y1 | Homo sapiens | 2MeSADP | - | chim(NtGi1-G11)/&β;1/&γ;2 | 2.9 | 2023-06-07 | 10.1093/procel/pwac025 | |
7XXI | A | Nucleotide | P2Y | P2Y12 | Homo sapiens | 2MeSADP | - | Gi2/&β;1/&γ;2 | 3 | 2023-06-07 | 10.1093/procel/pwac025 | |
6LPB | B1 | Peptide | VIP and PACAP | PAC1 | Homo sapiens | PACAP | - | Gs/&β;1/&γ;1 | 3.9 | 2020-03-11 | 10.1038/s41594-020-0386-8 | |
6M1H | B1 | Peptide | VIP and PACAP | PAC1 | Homo sapiens | Maxadilan | - | Gs/&β;1/&γ;2 | 3.6 | 2020-03-11 | 10.1038/s41422-020-0280-2 | |
6M1I | B1 | Peptide | VIP and PACAP | PAC1 | Homo sapiens | PACAP | - | Gs/&β;1/&γ;2 | 3.5 | 2020-03-11 | 10.1038/s41422-020-0280-2 | |
6P9Y | B1 | Peptide | VIP and PACAP | PAC1 | Homo sapiens | PACAP | - | Gs/&β;1/&γ;2 | 3.01 | 2020-02-05 | 10.1016/j.molcel.2020.01.012 | |
8E3X | B1 | Peptide | VIP and PACAP | PAC1 | Homo sapiens | PACAP27 | - | Gs/&β;1/&γ;2 | 2.3 | 2022-11-23 | 10.1038/s41467-022-34629-3 | |
6NBF | B1 | Peptide | Parathyroid hormone | PTH1 | Homo sapiens | Long-acting PTH analog | - | Gs/&β;1/&γ;2 | 3 | 2019-04-17 | 10.1126/science.aav7942 | |
6NBH | B1 | Peptide | Parathyroid hormone | PTH1 | Homo sapiens | Long-acting PTH analog | - | Gs/&β;1/&γ;2 | 3.5 | 2019-04-17 | 10.1126/science.aav7942 | |
6NBI | B1 | Peptide | Parathyroid hormone | PTH1 | Homo sapiens | Long-acting PTH analog | - | Gs/&β;1/&γ;2 | 4 | 2019-04-17 | 10.1126/science.aav7942 | |
7VVJ | B1 | Peptide | Parathyroid hormone | PTH1 | Homo sapiens | PTHrP(1-36) | - | Gs/&β;1/&γ;2 | 3.2 | 2022-08-03 | 10.1016/j.molcel.2022.07.003 | |
7VVK | B1 | Peptide | Parathyroid hormone | PTH1 | Homo sapiens | PTH | - | Gs/&β;1/&γ;2 | 3.3 | 2022-08-03 | 10.1016/j.molcel.2022.07.003 | |
7VVL | B1 | Peptide | Parathyroid hormone | PTH1 | Homo sapiens | PTH | - | Gs/&β;1/&γ;2 | 2.8 | 2022-08-03 | 10.1016/j.molcel.2022.07.003 | |
7VVM | B1 | Peptide | Parathyroid hormone | PTH1 | Homo sapiens | PTH | - | Gs/&β;1/&γ;2 | 3.2 | 2022-08-03 | 10.1016/j.molcel.2022.07.003 | |
7VVN | B1 | Peptide | Parathyroid hormone | PTH1 | Homo sapiens | PTH | - | Gs/&β;1/&γ;2 | 3.8 | 2022-08-03 | 10.1016/j.molcel.2022.07.003 | |
7VVO | B1 | Peptide | Parathyroid hormone | PTH1 | Homo sapiens | PTH | - | Gs/&β;1/&γ;2 | 4.1 | 2022-08-03 | 10.1016/j.molcel.2022.07.003 | |
7Y35 | B1 | Peptide | Parathyroid hormone | PTH1 | Homo sapiens | Abaloparatide | - | Gs/&β;1/&γ;2 | 2.9 | 2023-07-05 | To be published | |
7Y36 | B1 | Peptide | Parathyroid hormone | PTH1 | Homo sapiens | Teriparatide | - | Gs/&β;1/&γ;2 | 2.8 | 2023-07-05 | To be published | |
8FLQ | B1 | Peptide | Parathyroid hormone | PTH1 | Homo sapiens | PTH | - | Gs/&β;1/&γ;2 | 2.55 | 2023-04-26 | 10.1016/j.str.2023.04.002 | |
8FLR | B1 | Peptide | Parathyroid hormone | PTH1 | Homo sapiens | PTHrP(1-36) | - | Gs/&β;1/&γ;2 | 2.94 | 2023-04-26 | 10.1016/j.str.2023.04.002 | |
8FLS | B1 | Peptide | Parathyroid hormone | PTH1 | Homo sapiens | Abaloparatide | - | Gs/&β;1/&γ;2 | 3.09 | 2023-04-26 | 10.1016/j.str.2023.04.002 | |
8FLT | B1 | Peptide | Parathyroid hormone | PTH1 | Homo sapiens | M-PTH(1-14) | - | Gs/&β;1/&γ;2 | 3.03 | 2023-04-26 | 10.1016/j.str.2023.04.002 | |
8FLU | B1 | Peptide | Parathyroid hormone | PTH1 | Homo sapiens | Long-acting PTH | - | Gs/&β;1/&γ;2 | 2.76 | 2023-04-26 | 10.1016/j.str.2023.04.002 | |
8GW8 | B1 | Peptide | Parathyroid hormone | PTH1 | Homo sapiens | - | KHF | Gs/&β;1/&γ;2 | 2.9 | 2023-06-14 | 10.1038/s41586-023-06169-3 | |
8HA0 | B1 | Peptide | Parathyroid hormone | PTH1 | Homo sapiens | PTH | - | chim(NtGi1-Gs)/&β;1/&γ;2 | 2.62 | 2022-12-21 | 10.1038/s41401-022-01032-z | |
8HAF | B1 | Peptide | Parathyroid hormone | PTH1 | Homo sapiens | PTHrP(1-36) | - | chim(NtGi1-Gs)/&β;1/&γ;2 | 3.25 | 2022-12-21 | 10.1038/s41401-022-01032-z | |
8HAO | B1 | Peptide | Parathyroid hormone | PTH1 | Homo sapiens | PTH | - | chim(NtGi1-Gs)/&β;1/&γ;2 | 3.76 | 2022-12-21 | 10.1038/s41401-022-01032-z | |
8JR9 | B1 | Peptide | Parathyroid hormone | PTH1 | Homo sapiens | - | PCO371 | chim(NtGi1-Gs)/&β;1/&γ;2 | 2.57 | 2023-08-02 | 10.1038/s41586-023-06467-w | |
7F16 | B1 | Peptide | Parathyroid hormone | PTH2 | Homo sapiens | TIP39 | - | Gs/&β;1/&γ;2 | 2.8 | 2021-08-18 | 10.1073/pnas.2101279118 | |
2X72 | A | Sensory | Opsins | Rhodopsin | Bos taurus | All-trans-retinal | - | Gt(CT) | 3 | 2011-03-16 | 10.1038/nature09795 | |
3DQB | A | Sensory | Opsins | Rhodopsin | Bos taurus | - | - | Gt(CT) | 3.2 | 2008-09-23 | 10.1038/nature07330 | |
3PQR | A | Sensory | Opsins | Rhodopsin | Bos taurus | All-trans-retinal | - | Gt(CT) | 2.85 | 2011-03-09 | 10.1038/nature09789 | |
4A4M | A | Sensory | Opsins | Rhodopsin | Bos taurus | All-trans-retinal | - | Gt(CT) | 3.3 | 2012-01-25 | 10.1073/pnas.1114089108 | |
4BEY | A | Sensory | Opsins | Rhodopsin | Bos taurus | - | - | Gt(CT) | 2.9 | 2013-05-08 | 10.1038/embor.2013.44 | |
4J4Q | A | Sensory | Opsins | Rhodopsin | Bos taurus | Octyl Beta-D-Glucopyranoside | - | Gt(CT) | 2.65 | 2013-10-30 | 10.1002/anie.201302374 | |
4X1H | A | Sensory | Opsins | Rhodopsin | Bos taurus | Nonyl Beta-D-Glucopyranoside | - | Gt(CT) | 2.29 | 2015-11-04 | 10.1016/j.str.2015.09.015 | |
5EN0 | A | Sensory | Opsins | Rhodopsin | Bos taurus | All-trans-retinal | - | Gt(CT) | 2.81 | 2016-08-10 | 10.15252/embr.201642671 | |
5WKT | A | Sensory | Opsins | Rhodopsin | Bos taurus | Octyl Beta-D-Glucopyranoside | - | Gt(CT) | 3.2 | 2017-12-13 | 10.1038/nprot.2017.135 | |
6CMO | A | Sensory | Opsins | Rhodopsin | Homo sapiens | - | - | Gi1/&β;1/&γ;2 | 4.5 | 2018-06-20 | 10.1038/s41586-018-0215-y | |
6FUF | A | Sensory | Opsins | Rhodopsin | Bos taurus | All-trans-retinal | - | Go/&β;1/&γ;2 | 3.12 | 2018-10-03 | 10.1126/sciadv.aat7052 | |
6NWE | A | Sensory | Opsins | Rhodopsin | Bos taurus | Octyl Beta-D-Glucopyranoside | - | Gt(CT) | 2.71 | 2020-02-12 | To be published | |
6OY9 | A | Sensory | Opsins | Rhodopsin | Bos taurus | All-trans-retinal | - | Gt/&β;1/&γ;1 | 3.9 | 2019-07-24 | 10.1016/j.molcel.2019.06.007 | |
6OYA | A | Sensory | Opsins | Rhodopsin | Bos taurus | All-trans-retinal | - | Gt/&β;1/&γ;1 | 3.3 | 2019-07-24 | 10.1016/j.molcel.2019.06.007 | |
6PEL | A | Sensory | Opsins | Rhodopsin | Bos taurus | - | Citronellol | Gt(CT) | 3.19 | 2020-06-24 | To be published | |
6PGS | A | Sensory | Opsins | Rhodopsin | Bos taurus | - | Geraniol | Gt(CT) | 2.9 | 2020-07-01 | To be published | |
6PH7 | A | Sensory | Opsins | Rhodopsin | Bos taurus | - | Nerol | Gt(CT) | 2.9 | 2020-07-01 | To be published | |
6QNO | A | Sensory | Opsins | Rhodopsin | Bos taurus | All-trans-retinal | - | Gi1/&β;1/&γ;1 | 4.38 | 2019-07-10 | 10.7554/eLife.46041 | |
7TMW | A | Peptide | Relaxin | RXFP1 | Homo sapiens | - | - | Gs/&β;1/&γ;2 | 3.2 | 2023-02-15 | 10.1101/2022.01.22.477343 | |
7YJ4 | A | Peptide | Relaxin | RXFP4 | Homo sapiens | INSL5 | - | Gi2/&β;1/&γ;2 | 3.19 | 2023-03-01 | 10.1038/s41467-023-36182-z | |
7YK6 | A | Peptide | Relaxin | RXFP4 | Homo sapiens | PubChem 138319674 | - | Gi2/&β;1/&γ;2 | 3.03 | 2023-03-01 | 10.1038/s41467-023-36182-z | |
7YK7 | A | Peptide | Relaxin | RXFP4 | Homo sapiens | DC591053 | - | Gi2/&β;1/&γ;2 | 2.75 | 2023-03-01 | 10.1038/s41467-023-36182-z | |
7EO2 | A | Lipid | Lysophospholipid (S1P) | S1P1 | Homo sapiens | FTY720-P | - | Gi1/&β;1/&γ;2 | 2.89 | 2022-01-05 | 10.1038/s41589-021-00930-3 | |
7EO4 | A | Lipid | Lysophospholipid (S1P) | S1P1 | Homo sapiens | BAF312 | - | Gi1/&β;1/&γ;2 | 2.86 | 2022-01-05 | 10.1038/s41589-021-00930-3 | |
7EVY | A | Lipid | Lysophospholipid (S1P) | S1P1 | Homo sapiens | Siponimod | - | Gi1/&β;1/&γ;2 | 2.98 | 2021-09-29 | 10.1038/s41422-021-00566-x | |
7EVZ | A | Lipid | Lysophospholipid (S1P) | S1P1 | Homo sapiens | Cenerimod | - | Gi1/&β;1/&γ;2 | 3.07 | 2021-09-29 | 10.1038/s41422-021-00566-x | |
7EW0 | A | Lipid | Lysophospholipid (S1P) | S1P1 | Homo sapiens | Ozanimod | - | Gi1/&β;1/&γ;2 | 3.42 | 2021-09-29 | 10.1038/s41422-021-00566-x | |
7EW7 | A | Lipid | Lysophospholipid (S1P) | S1P1 | Homo sapiens | PubChem 4077460 | - | Gi1/&β;1/&γ;2 | 3.27 | 2021-09-29 | 10.1038/s41422-021-00566-x | |
7TD3 | A | Lipid | Lysophospholipid (S1P) | S1P1 | Homo sapiens | S1P | - | Gi1/&β;1/&γ;2 | 3 | 2022-02-09 | 10.1038/s41467-022-28417-2 | |
7TD4 | A | Lipid | Lysophospholipid (S1P) | S1P1 | Homo sapiens | Siponimod | - | Gi1/&β;1/&γ;2 | 2.6 | 2022-02-09 | 10.1038/s41467-022-28417-2 | |
7VIE | A | Lipid | Lysophospholipid (S1P) | S1P1 | Homo sapiens | S1P | - | Gi1/&β;1/&γ;2 | 2.86 | 2022-09-28 | 10.1073/pnas.2117716119 | |
7VIF | A | Lipid | Lysophospholipid (S1P) | S1P1 | Homo sapiens | (S)-FTY720-P | - | Gi1/&β;1/&γ;2 | 2.83 | 2022-09-28 | 10.1073/pnas.2117716119 | |
7VIG | A | Lipid | Lysophospholipid (S1P) | S1P1 | Homo sapiens | CBP-307 | - | Gi1/&β;1/&γ;2 | 2.89 | 2022-09-28 | 10.1073/pnas.2117716119 | |
7VIH | A | Lipid | Lysophospholipid (S1P) | S1P1 | Homo sapiens | CBP-307 | - | Gi1/&β;1/&γ;2 | 2.98 | 2022-09-28 | 10.1073/pnas.2117716119 | |
7WF7 | A | Lipid | Lysophospholipid (S1P) | S1P1 | Homo sapiens | S1P | - | Gi1/&β;1/&γ;2 | 3.4 | 2022-01-05 | 10.1038/s41589-021-00930-3 | |
8G94 | A | Lipid | Lysophospholipid (S1P) | S1P1 | Homo sapiens | - | CD69 | Gi1/&β;1/&γ;2 | 3.15 | 2023-04-19 | 10.7554/eLife.88204 | |
7T6B | A | Lipid | Lysophospholipid (S1P) | S1P2 | Homo sapiens | S1P | - | chim(NtGi1L-G13)/&β;1/&γ;2 | 3.19 | 2022-04-06 | 10.1126/sciadv.abn0067 | |
7EW2 | A | Lipid | Lysophospholipid (S1P) | S1P3 | Homo sapiens | Fingolimod | - | Gi1/&β;1/&γ;2 | 3.1 | 2021-09-29 | 10.1038/s41422-021-00567-w | |
7EW3 | A | Lipid | Lysophospholipid (S1P) | S1P3 | Homo sapiens | S1P | - | Gi1/&β;1/&γ;2 | 3.1 | 2021-09-29 | 10.1038/s41422-021-00567-w | |
7EW4 | A | Lipid | Lysophospholipid (S1P) | S1P3 | Homo sapiens | CYM5541 | - | Gi1/&β;1/&γ;2 | 3.2 | 2021-09-29 | 10.1038/s41422-021-00567-w | |
7EW1 | A | Lipid | Lysophospholipid (S1P) | S1P5 | Homo sapiens | Siponimod | - | Gi1/&β;1/&γ;2 | 3.4 | 2021-09-29 | 10.1038/s41422-021-00566-x | |
6WI9 | B1 | Peptide | Glucagon | Secretin | Homo sapiens | Secretin | - | Gs/&β;1/&γ;2 | 4.3 | 2020-08-12 | 10.1038/s41467-020-17791-4 | |
6WZG | B1 | Peptide | Glucagon | Secretin | Homo sapiens | Secretin | - | Gs/&β;1/&γ;2 | 2.3 | 2020-08-12 | 10.1038/s41467-020-17791-4 | |
7D3S | B1 | Peptide | Glucagon | Secretin | Homo sapiens | Secretin | - | Gs/&β;1/&γ;2 | 2.9 | 2020-11-04 | 10.1016/j.bbrc.2020.08.042 | |
6OT0 | F | Protein | Frizzled | SMO | Homo sapiens | - | 25(S)-Epoxycholesterol | Gi1/&β;1/&γ;2 | 3.84 | 2019-06-12 | 10.1038/s41586-019-1286-0 | |
6XBJ | F | Protein | Frizzled | SMO | Homo sapiens | - | Cholesterol | Gi1/&β;1/&γ;2 | 3.88 | 2020-09-30 | 10.1038/s41589-020-0646-2 | |
6XBK | F | Protein | Frizzled | SMO | Homo sapiens | - | Cholesterol | Gi1/&β;1/&γ;2 | 3.24 | 2020-09-30 | 10.1038/s41589-020-0646-2 | |
6XBL | F | Protein | Frizzled | SMO | Homo sapiens | SAG | Cholesterol | Gi1/&β;1/&γ;2 | 3.96 | 2020-09-30 | 10.1038/s41589-020-0646-2 | |
6XBM | F | Protein | Frizzled | SMO | Homo sapiens | - | 25(S)-Epoxycholesterol | Gi1/&β;1/&γ;2 | 3.14 | 2020-09-30 | 10.1038/s41589-020-0646-2 | |
7WIC | A | Peptide | Somatostatin | SST2 | Homo sapiens | Somatostatin-14 | - | Gi1/&β;1/&γ;2 | 2.8 | 2022-06-01 | 10.1038/s41422-022-00669-z | |
7WIG | A | Peptide | Somatostatin | SST2 | Homo sapiens | L-054,264 | - | Gi1/&β;1/&γ;2 | 2.7 | 2022-06-01 | 10.1038/s41422-022-00669-z | |
7WJ5 | A | Peptide | Somatostatin | SST2 | Homo sapiens | Somatostatin-14 | - | Gi1/&β;1/&γ;2 | 3.72 | 2022-07-13 | 10.7554/eLife.76823 | |
7XAT | A | Peptide | Somatostatin | SST2 | Homo sapiens | Somatostatin-14 | - | Gi1/&β;1/&γ;2 | 2.85 | 2022-08-31 | 10.1038/s41421-022-00405-2 | |
7XAU | A | Peptide | Somatostatin | SST2 | Homo sapiens | Octreotide | - | Gi1/&β;1/&γ;2 | 2.97 | 2022-08-31 | 10.1038/s41421-022-00405-2 | |
7XAV | A | Peptide | Somatostatin | SST2 | Homo sapiens | Lanreotide | - | Gi1/&β;1/&γ;2 | 2.87 | 2022-08-31 | 10.1038/s41421-022-00405-2 | |
7XMR | A | Peptide | Somatostatin | SST2 | Homo sapiens | Somatostatin-14 | - | Gi1/&β;1/&γ;2 | 3.1 | 2022-08-03 | 10.1038/s41422-022-00679-x | |
7Y24 | A | Peptide | Somatostatin | SST2 | Homo sapiens | Octreotide | - | Go/&β;1/&γ;2 | 3.25 | 2022-10-19 | 10.1038/s41589-022-01130-3 | |
7Y26 | A | Peptide | Somatostatin | SST2 | Homo sapiens | Octreotide | - | chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 | 3.3 | 2022-10-19 | 10.1038/s41589-022-01130-3 | |
7Y27 | A | Peptide | Somatostatin | SST2 | Homo sapiens | Somatostatin-14 | - | chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 | 3.48 | 2022-10-19 | 10.1038/s41589-022-01130-3 | |
7YAC | A | Peptide | Somatostatin | SST2 | Homo sapiens | Paltusotine | - | Gi1/&β;1/&γ;2 | 3.24 | 2023-04-19 | 10.1038/s41467-023-36673-z | |
7YAE | A | Peptide | Somatostatin | SST2 | Homo sapiens | Octreotide | - | Gi1/&β;1/&γ;2 | 3.37 | 2023-04-19 | 10.1038/s41467-023-36673-z | |
7XMS | A | Peptide | Somatostatin | SST4 | Homo sapiens | Somatostatin-14 | - | Gi1/&β;1/&γ;2 | 2.9 | 2022-08-03 | 10.1038/s41422-022-00679-x | |
7XMT | A | Peptide | Somatostatin | SST4 | Homo sapiens | J-2156 | - | Gi1/&β;1/&γ;2 | 2.8 | 2022-08-03 | 10.1038/s41422-022-00679-x | |
7AD3 | D1 | Ste2-like | STE2 | STE2 | Saccharomyces cerevisiae | Alpha-factor mating pheromone | - | Gi1/STE4/&γ;2 | 3.3 | 2020-12-09 | 10.1038/s41586-020-2994-1 | |
7XP4 | T | Sensory | Taste2 | T2R46 | Homo sapiens | - | - | chim(Gs-CtGt3)/&β;1/&γ;2 | 3.01 | 2022-10-12 | 10.1126/science.abo1633 | |
7XP5 | T | Sensory | Taste2 | T2R46 | Homo sapiens | - | - | chim(Gs-CtGt3)/&β;1/&γ;2 | 3.08 | 2022-10-12 | 10.1126/science.abo1633 | |
7XP6 | T | Sensory | Taste2 | T2R46 | Homo sapiens | Strychnine | - | chim(Gs-CtGt3)/&β;1/&γ;2 | 3.01 | 2022-10-12 | 10.1126/science.abo1633 | |
8JLJ | A | Amine | Trace amine receptors | TA1 | Mus musclus | T1AM | - | chim(NtGi1-Gs)/&β;1/&γ;2 | 3.1 | 2023-11-15 | 10.1038/s41586-023-06804-z | |
8JLK | A | Amine | Trace amine receptors | TA1 | Mus musclus | Ulotaront | - | chim(NtGi1-Gs)/&β;1/&γ;2 | 3.22 | 2023-11-15 | 10.1038/s41586-023-06804-z | |
8JLN | A | Amine | Trace amine receptors | TA1 | Homo sapiens | T1AM | - | Gs/&β;1/&γ;2 | 3.24 | 2023-11-15 | 10.1038/s41586-023-06804-z | |
8JLO | A | Amine | Trace amine receptors | TA1 | Homo sapiens | Ulotaront | - | Gs/&β;1/&γ;2 | 3.52 | 2023-11-15 | 10.1038/s41586-023-06804-z | |
8JLP | A | Amine | Trace amine receptors | TA1 | Homo sapiens | Ralmitaront | - | Gs/&β;1/&γ;2 | 3.23 | 2023-11-15 | 10.1038/s41586-023-06804-z | |
8JLQ | A | Amine | Trace amine receptors | TA1 | Homo sapiens | Fenoldopam | - | Gs/&β;1/&γ;2 | 2.84 | 2023-11-15 | 10.1038/s41586-023-06804-z | |
8JLR | A | Amine | Trace amine receptors | TA1 | Homo sapiens | A77636 | - | chim(NtGi1-Gs)/&β;1/&γ;2 | 3 | 2023-11-15 | 10.1038/s41586-023-06804-z | |
8JSO | A | Amine | Trace amine receptors | TA1 | Homo sapiens | AMPH | - | chim(NtGi1-Gs)/&β;1/&γ;2 | 3.4 | 2023-11-15 | 10.1038/s41586-023-06804-z | |
8UHB | A | Amine | Trace amine receptors | TA1 | Homo sapiens | RO5256390 | - | Gs/&β;1/&γ;2 | 3.35 | 2024-01-10 | 10.1038/s41467-023-44601-4 | |
8W87 | A | Amine | Trace amine receptors | TA1 | Homo sapiens | METH | - | chim(NtGi1L-Gs)/&β;1/&γ;2 | 2.8 | 2023-11-22 | 10.1038/s41586-023-06775-1 | |
8W88 | A | Amine | Trace amine receptors | TA1 | Homo sapiens | SEP-363856 | - | Gs/&β;1/&γ;2 | 2.6 | 2023-11-22 | 10.1038/s41586-023-06775-1 | |
8W89 | A | Amine | Trace amine receptors | TA1 | Homo sapiens | PEA | - | chim(NtGi1L-Gs)/&β;1/&γ;2 | 3 | 2023-11-22 | 10.1038/s41586-023-06775-1 | |
8W8A | A | Amine | Trace amine receptors | TA1 | Homo sapiens | RO5256390 | - | chim(NtGi1L-Gs)/&β;1/&γ;2 | 2.8 | 2023-11-22 | 10.1038/s41586-023-06775-1 | |
8WC3 | A | Amine | Trace amine receptors | TA1 | Mus musculus | SEP-363856 | - | chim(NtGi1-Gs)/&β;1/&γ;2 | 3 | 2023-12-27 | 10.1016/j.cell.2023.10.014 | |
8WC4 | A | Amine | Trace amine receptors | TA1 | Mus musculus | ZH8651 | - | chim(NtGi1-Gs)/&β;1/&γ;2 | 3.1 | 2023-12-27 | 10.1016/j.cell.2023.10.014 | |
8WC5 | A | Amine | Trace amine receptors | TA1 | Mus musculus | Tetramethylammonium ion | - | chim(NtGi1-Gs)/&β;1/&γ;2 | 3.3 | 2023-12-27 | 10.1016/j.cell.2023.10.014 | |
8WC6 | A | Amine | Trace amine receptors | TA1 | Mus musculus | 2-Phenylethylamine | - | chim(NtGi1-Gs)/&β;1/&γ;2 | 3.2 | 2023-12-27 | 10.1016/j.cell.2023.10.014 | |
8WC7 | A | Amine | Trace amine receptors | TA1 | Mus musculus | ZH8667 | - | chim(NtGi1-Gs)/&β;1/&γ;2 | 3.1 | 2023-12-27 | 10.1016/j.cell.2023.10.014 | |
8WC8 | A | Amine | Trace amine receptors | TA1 | Mus musculus | ZH8651 | - | chim(NtGi1-Gs)/&β;1/&γ;2 | 2.9 | 2023-12-27 | 10.1016/j.cell.2023.10.014 | |
8WC9 | A | Amine | Trace amine receptors | TA1 | Mus musculus | ZH8651 | - | chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 | 3.2 | 2023-12-27 | 10.1016/j.cell.2023.10.014 | |
8WCA | A | Amine | Trace amine receptors | TA1 | Homo sapiens | 2-Phenylethylamine | - | chim(NtGi1-Gs)/&β;1/&γ;2 | 3.48 | 2023-12-27 | 10.1016/j.cell.2023.10.014 | |
8WCB | A | Amine | Trace amine receptors | TA1 | Mus musculus | Cyclohexylammonium ion | - | chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 | 3.1 | 2023-12-27 | 10.1016/j.cell.2023.10.014 | |
8ITF | A | Orphan | A orphans | TAAR9 | Mus musculus | DMCHA | - | chim(NtGi1-Gs)/&β;1/&γ;2 | 3.46 | 2023-05-31 | 10.1038/s41586-023-06106-4 | |
8IW1 | A | Orphan | A orphans | TAAR9 | Mus musculus | - | - | chim(NtGi1-Gs)/&β;1/&γ;2 | 3.4 | 2023-05-31 | 10.1038/s41586-023-06106-4 | |
8IW4 | A | Orphan | A orphans | TAAR9 | Mus musculus | Spermidine | - | chim(NtGi1-Gs)/&β;1/&γ;2 | 3.49 | 2023-05-31 | 10.1038/s41586-023-06106-4 | |
8IW7 | A | Orphan | A orphans | TAAR9 | Mus musculus | 2-Phenylethylamine | - | chim(NtGi1-Gs)/&β;1/&γ;2 | 2.97 | 2023-05-31 | 10.1038/s41586-023-06106-4 | |
8IW9 | A | Orphan | A orphans | TAAR9 | Mus musculus | - | - | chim(NtGi1-Gs)/&β;1/&γ;2 | 3.08 | 2023-05-31 | 10.1038/s41586-023-06106-4 | |
8XJO | A | Lipid | Prostanoid | TP | Homo sapiens | U46619 | - | chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 | 3.11 | 2024-02-28 | To be published | |
7WKD | A | Peptide | Thyrotropin-releasing hormone | TRH | Homo sapiens | TRH | - | chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 | 3.01 | 2022-06-15 | 10.1038/s41422-022-00641-x | |
7X1T | A | Peptide | Thyrotropin-releasing hormone | TRH | Homo sapiens | Taltirelin | - | chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 | 3.26 | 2022-08-31 | 10.1038/s41422-022-00646-6 | |
7X1U | A | Peptide | Thyrotropin-releasing hormone | TRH | Homo sapiens | TRH | - | chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 | 3.19 | 2022-08-31 | 10.1038/s41422-022-00646-6 | |
7XW9 | A | Peptide | Thyrotropin-releasing hormone | TRH | Homo sapiens | TRH | - | chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 | 2.7 | 2022-12-28 | 10.1038/s41421-022-00477-0 | |
7T9I | A | Protein | Glycoprotein hormone | TSH | Homo sapiens | TSH | - | Gs/&β;1/&γ;2 | 2.9 | 2022-08-03 | 10.1038/s41586-022-05159-1 | |
7T9N | A | Protein | Glycoprotein hormone | TSH | Homo sapiens | M22 Fab | PubChem 644078 | Gs/&β;1/&γ;2 | 2.9 | 2022-08-03 | 10.1038/s41586-022-05159-1 | |
7UTZ | A | Protein | Glycoprotein hormone | TSH | Homo sapiens | TR1402 | PubChem 644078 | Gs/&β;1/&γ;2 | 2.4 | 2022-08-03 | 10.1038/s41586-022-05159-1 | |
7XW5 | A | Protein | Glycoprotein hormone | TSH | Homo sapiens | TSH | ML109 | Gs/&β;1/&γ;2 | 2.96 | 2022-08-24 | 10.1038/s41586-022-05173-3 | |
7XW6 | A | Protein | Glycoprotein hormone | TSH | Homo sapiens | M22 Fab | ML109 | Gs/&β;1/&γ;2 | 2.78 | 2022-08-17 | 10.1038/s41586-022-05173-3 | |
7RKX | A | Other | Unclassified | US27 | Human betaherpesvirus 5 | - | - | Gi1/&β;1/&γ;2 | 3.1 | 2022-01-26 | 10.1126/sciadv.abl5442 | |
7RKF | A | Other | Unclassified | US28 | Human betaherpesvirus 5 | Fractalkine | GDP | chim(NtGi1-G11)/&β;1/&γ;2 | 4 | 2022-01-26 | 10.1126/sciadv.abl5442 | |
7RKM | A | Other | Unclassified | US28 | Human betaherpesvirus 5 | Fractalkine | - | Gi1/&β;1/&γ;2 | 3.5 | 2022-01-26 | 10.1126/sciadv.abl5442 | |
7RKN | A | Other | Unclassified | US28 | Human betaherpesvirus 5 | Fractalkine | - | Gi1/&β;1/&γ;2 | 3.6 | 2022-01-26 | 10.1126/sciadv.abl5442 | |
7BB6 | A | Peptide | Vasopressin and oxytocin | V2 | Homo sapiens | AVP | - | Gs/&β;1/&γ;2 | 4.2 | 2021-06-02 | 10.1126/sciadv.abg5628 | |
7BB7 | A | Peptide | Vasopressin and oxytocin | V2 | Homo sapiens | AVP | - | Gs/&β;1/&γ;2 | 4.4 | 2021-06-02 | 10.1126/sciadv.abg5628 | |
7DW9 | A | Peptide | Vasopressin and oxytocin | V2 | Homo sapiens | AVP | - | chim(NtGi1-Gs)/&β;1/&γ;2 | 2.6 | 2021-07-21 | 10.1038/s41422-021-00480-2 | |
7KH0 | A | Peptide | Vasopressin and oxytocin | V2 | Homo sapiens | AVP | - | chim(NtGi1-Gs)/&β;1/&γ;2 | 2.8 | 2021-05-26 | 10.1038/s41422-021-00483-z | |
6VN7 | B1 | Peptide | VIP and PACAP | VPAC1 | Homo sapiens | PACAP | - | Gs/&β;1/&γ;2 | 3.2 | 2020-09-02 | 10.1038/s41467-020-17933-8 | |
8E3Y | B1 | Peptide | VIP and PACAP | VPAC1 | Homo sapiens | PACAP27 | - | Gs/&β;1/&γ;2 | 2.3 | 2022-11-23 | 10.1038/s41467-022-34629-3 | |
8E3Z | B1 | Peptide | VIP and PACAP | VPAC1 | Homo sapiens | VIP | - | Gs/&β;1/&γ;2 | 2.7 | 2022-11-23 | 10.1038/s41467-022-34629-3 | |
7VQX | B1 | Peptide | VIP and PACAP | VPAC1 | Homo sapiens | PACAP27 | - | Gs/&β;1/&γ;2 | 2.74 | 2022-05-18 | 10.1038/s41467-022-30041-z | |
7WBJ | B1 | Peptide | VIP and PACAP | VPAC1 | Homo sapiens | PACAP27 | - | Gs/&β;1/&γ;2 | 3.42 | 2022-05-18 | 10.1038/s41467-022-30041-z | |
7VGX | A | Peptide | Neuropeptide Y | Y1 | Homo sapiens | Neuropeptide Y | - | Gi1/&β;1/&γ;2 | 3.2 | 2022-02-23 | 10.1038/s41467-022-28510-6 | |
7X9A | A | Peptide | Neuropeptide Y | Y1 | Homo sapiens | Neuropeptide Y | - | Gi1/&β;1/&γ;2 | 3.2 | 2022-05-18 | 10.1126/sciadv.abm1232 | |
7X9B | A | Peptide | Neuropeptide Y | Y2 | Homo sapiens | Neuropeptide Y | - | Gi1/&β;1/&γ;2 | 3.4 | 2022-05-18 | 10.1126/sciadv.abm1232 | |
7YON | A | Peptide | Neuropeptide Y | Y2 | Homo sapiens | Peptide YY(3-36) | - | Gi1/&β;1/&γ;2 | 2.95 | 2023-03-22 | 10.1016/j.str.2022.11.010 | |
7YOO | A | Peptide | Neuropeptide Y | Y2 | Homo sapiens | Neuropeptide Y | - | Gi1/&β;1/&γ;2 | 3.11 | 2023-03-22 | 10.1016/j.str.2022.11.010 | |
7X9C | A | Peptide | Neuropeptide Y | Y4 | Homo sapiens | Pancreatic Hormone | - | Gi1/&β;1/&γ;2 | 3 | 2022-05-18 | 10.1126/sciadv.abm1232 |