All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.
Show: Click this button to access the corresponding database entry page.
PDB: PDB code of the receptor used to compute the network and a direct link to the corresponding entry in the Protein Data Bank.
Class: Receptor Class.
SubFamily: Receptor Sub Family.
Type: Receptor Type.
Subtype: Receptor SubType.
Species: Organism.
Orthosteric Ligand: Name of the orthosteric ligand, if present.
Other Ligand(s): Name of other allosteric ligands, if present.
Protein Partners: G Protein, Arrestin or Kinase coupled to a given receptor.
Resolution: Structure resolution.
Date: Deposition date.
DOI: DOI and link of the corresponding paper.
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 7E2X | A | Amine | 5-Hydroxytryptamine | 5-HT1A | Homo sapiens | - | - | Gi1/β1/γ2 | 3 | 2021-04-14 | doi.org/10.1038/s41586-021-03376-8 | |
| 7E2Y | A | Amine | 5-Hydroxytryptamine | 5-HT1A | Homo sapiens | Serotonin | - | Gi1/β1/γ2 | 3 | 2021-04-14 | doi.org/10.1038/s41586-021-03376-8 | |
| 7E2Z | A | Amine | 5-Hydroxytryptamine | 5-HT1A | Homo sapiens | Aripiprazole | - | Gi1/β1/γ2 | 3.1 | 2021-04-14 | doi.org/10.1038/s41586-021-03376-8 | |
| 8W8B | A | Amine | 5-Hydroxytryptamine | 5-HT1A | Homo sapiens | SEP-363856 | - | Gi1/β1/γ2 | 3 | 2023-11-22 | doi.org/10.1038/s41586-023-06775-1 | |
| 8JSP | A | Amine | 5-Hydroxytryptamine | 5-HT1A | Homo sapiens | Ulotaront | - | Gi1/β1/γ2 | 3.65 | 2023-11-15 | doi.org/10.1038/s41586-023-06804-z | |
| 8FY8 | A | Amine | 5-Hydroxytryptamine | 5-HT1A | Homo sapiens | 5-MeO-DMT | - | Gi1/β1/γ1 | 2.79 | 2024-05-15 | doi.org/10.1038/s41586-024-07403-2 | |
| 8FYE | A | Amine | 5-Hydroxytryptamine | 5-HT1A | Homo sapiens | 4-F,5-MeO-PyrT | - | Gi1/β1/γ1 | 2.85 | 2024-05-15 | doi.org/10.1038/s41586-024-07403-2 | |
| 8FYL | A | Amine | 5-Hydroxytryptamine | 5-HT1A | Homo sapiens | Vilazodone | - | Gi1/β1/γ1 | 2.94 | 2024-05-15 | doi.org/10.1038/s41586-024-07403-2 | |
| 8FYT | A | Amine | 5-Hydroxytryptamine | 5-HT1A | Homo sapiens | LSD | - | Gi1/β1/γ1 | 2.64 | 2024-05-15 | doi.org/10.1038/s41586-024-07403-2 | |
| 8FYX | A | Amine | 5-Hydroxytryptamine | 5-HT1A | Homo sapiens | Buspirone | - | Gi1/β1/γ1 | 2.72 | 2024-05-15 | doi.org/10.1038/s41586-024-07403-2 | |
| 8JT6 | A | Amine | 5-Hydroxytryptamine | 5-HT1A | Homo sapiens | (R)-IHCH-7179 | - | Gi1/β1/γ2 | 3 | 2024-02-28 | doi.org/10.1016/j.cell.2024.02.034 | |
| 8PJK | A | Amine | 5-Hydroxytryptamine | 5-HT1A | Homo sapiens | ST171 | - | Gi1/β1/γ1 | 2.4 | 2024-05-29 | doi.org/10.1126/sciadv.adv9267 | |
| 8PKM | A | Amine | 5-Hydroxytryptamine | 5-HT1A | Homo sapiens | Befiradol | - | Gi1/β1/γ1 | 2.9 | 2024-05-29 | doi.org/10.1126/sciadv.adv9267 | |
| 9GL2 | A | Amine | 5-Hydroxytryptamine | 5-HT1A | Homo sapiens | Befiradol | - | Gs/β1/γ2 | 3.2 | 2025-07-02 | doi.org/10.1126/sciadv.adv9267 | |
| 6G79 | A | Amine | 5-Hydroxytryptamine | 5-HT1B | Homo sapiens | Donitriptan | - | Go/β1/γ2 | 3.78 | 2018-06-20 | doi.org/10.1038/s41586-018-0241-9 | |
| 7E32 | A | Amine | 5-Hydroxytryptamine | 5-HT1D | Homo sapiens | Serotonin | - | Gi1/β1/γ2 | 2.9 | 2021-04-21 | doi.org/10.1038/s41586-021-03376-8 | |
| 7E33 | A | Amine | 5-Hydroxytryptamine | 5-HT1E | Homo sapiens | BRL-54443 | - | Gi1/β1/γ2 | 2.9 | 2021-04-14 | doi.org/10.1038/s41586-021-03376-8 | |
| 8UGY | A | Amine | 5-Hydroxytryptamine | 5-HT1E | Homo sapiens | Mianserin | - | Gi1/β1/γ1 | 3.31 | 2024-05-01 | doi.org/10.1126/sciadv.adk4855 | |
| 8UH3 | A | Amine | 5-Hydroxytryptamine | 5-HT1E | Homo sapiens | Setiptiline | - | Gi1/β1/γ1 | 3.31 | 2024-05-01 | doi.org/10.1126/sciadv.adk4855 | |
| 7EXD | A | Amine | 5-Hydroxytryptamine | 5-HT1F | Homo sapiens | Lasmiditan | - | Gi1/β1/γ2 | 3.4 | 2021-08-04 | doi.org/10.1038/s41422-021-00527-4 | |
| 6WHA | A | Amine | 5-Hydroxytryptamine | 5-HT2A | Homo sapiens | DB13948 | - | chim(NtGi2L-Gs-CtGq)/β1/γ2 | 3.36 | 2020-09-23 | doi.org/10.1016/j.cell.2020.08.024 | |
| 7RAN | A | Amine | 5-Hydroxytryptamine | 5-HT2A | Homo sapiens | PubChem 164575847 | - | chim(NtGi2L-Gs-CtGq)/β1/γ2 | 3.45 | 2022-07-06 | doi.org/10.1038/s41586-022-05258-z | |
| 8UWL | A | Amine | 5-Hydroxytryptamine | 5-HT2A | Homo sapiens | Lisuride | - | chim(NtGi2-Gs-CtGq)/β1/γ2 | 2.8 | 2024-05-29 | doi.org/10.1126/science.adn6354 | |
| 8V6U | A | Amine | 5-Hydroxytryptamine | 5-HT2A | Homo sapiens | PubChem 171392456 | - | chim(NtGi2-Gs-CtGq)/β1/γ2 | 3 | 2024-05-29 | doi.org/10.1126/science.adn6354 | |
| 9ARY | A | Amine | 5-Hydroxytryptamine | 5-HT2A | Homo sapiens | Serotonin | - | chim(NtGi1-Gs-CtGq)/β1/γ2 | 3.27 | 2025-04-02 | doi.org/10.1038/s41467-025-57956-7 | |
| 9AS0 | A | Amine | 5-Hydroxytryptamine | 5-HT2A | Homo sapiens | 2-bromo-LSD | - | chim(NtGi1-Gs-CtGq)/β1/γ2 | 3.38 | 2025-04-02 | doi.org/10.1038/s41467-025-57956-7 | |
| 9AS2 | A | Amine | 5-Hydroxytryptamine | 5-HT2A | Homo sapiens | DMT | - | chim(NtGi1-Gs-CtGq)/β1/γ2 | 3.21 | 2025-04-02 | doi.org/10.1038/s41467-025-57956-7 | |
| 9AS4 | A | Amine | 5-Hydroxytryptamine | 5-HT2A | Homo sapiens | LSD | - | chim(NtGi1-Gs-CtGq)/β1/γ2 | 3.06 | 2025-04-02 | doi.org/10.1038/s41467-025-57956-7 | |
| 9AS6 | A | Amine | 5-Hydroxytryptamine | 5-HT2A | Homo sapiens | Mescaline | - | chim(NtGi1-Gs-CtGq)/β1/γ2 | 3.07 | 2025-04-02 | doi.org/10.1038/s41467-025-57956-7 | |
| 9ASA | A | Amine | 5-Hydroxytryptamine | 5-HT2A | Homo sapiens | RS130-180 | - | chim(NtGi1-Gs-CtGq)/β1/γ2 | 3.12 | 2025-04-02 | doi.org/10.1038/s41467-025-57956-7 | |
| 7SRR | A | Amine | 5-Hydroxytryptamine | 5-HT2B | Homo sapiens | LSD | - | chim(NtGi2L-Gs-CtGq)/β1/γ2 | 2.9 | 2022-09-21 | doi.org/10.1016/j.neuron.2022.08.006 | |
| 8DPF | A | Amine | 5-Hydroxytryptamine | 5-HT2C | Homo sapiens | Lorcaserin | - | chim(NtGi2L-Gs-CtGq)/β1/γ2 | 2.84 | 2022-08-24 | doi.org/10.1016/j.celrep.2022.111211 | |
| 8DPG | A | Amine | 5-Hydroxytryptamine | 5-HT2C | Homo sapiens | Psilocin | - | chim(NtGi2L-Gs-CtGq)/β1/γ2 | 3.6 | 2022-08-24 | doi.org/10.1016/j.celrep.2022.111211 | |
| 8DPH | A | Amine | 5-Hydroxytryptamine | 5-HT2C | Homo sapiens | Lorcaserin | - | chim(NtGi2L-Gs-CtGq)/β1/γ2 | 3.2 | 2022-08-24 | doi.org/10.1016/j.celrep.2022.111211 | |
| 8DPI | A | Amine | 5-Hydroxytryptamine | 5-HT2C | Homo sapiens | Lorcaserin | - | chim(NtGi2L-Gs-CtGq)/β1/γ2 | 3.4 | 2022-08-24 | doi.org/10.1016/j.celrep.2022.111211 | |
| 7XT8 | A | Amine | 5-Hydroxytryptamine | 5-HT4 | Homo sapiens | Serotonin | - | Gs/β1/γ2 | 3.1 | 2022-07-27 | doi.org/10.1016/j.molcel.2022.05.031 | |
| 7XT9 | A | Amine | 5-Hydroxytryptamine | 5-HT4 | Homo sapiens | Serotonin | - | Gs/β1/γ2 | 3.2 | 2022-07-27 | doi.org/10.1016/j.molcel.2022.05.031 | |
| 7XTA | A | Amine | 5-Hydroxytryptamine | 5-HT4 | Homo sapiens | Serotonin | - | Gi1/β1/γ2 | 3.2 | 2022-07-27 | doi.org/10.1016/j.molcel.2022.05.031 | |
| 7X5H | A | Amine | 5-Hydroxytryptamine | 5-HT5A | Homo sapiens | 5-CT | - | Gi1/β1/γ2 | 3.1 | 2022-09-14 | doi.org/10.1038/s41421-022-00412-3 | |
| 7UM5 | A | Amine | 5-Hydroxytryptamine | 5-HT5A | Homo sapiens | 5-CT | - | chim(NtGi1-Go)/β1/γ2 | 2.73 | 2022-07-20 | doi.org/10.1038/s41594-022-00796-6 | |
| 7UM6 | A | Amine | 5-Hydroxytryptamine | 5-HT5A | Homo sapiens | Lisuride | - | chim(NtGi1-Go)/β1/γ2 | 2.79 | 2022-07-20 | doi.org/10.1038/s41594-022-00796-6 | |
| 7UM7 | A | Amine | 5-Hydroxytryptamine | 5-HT5A | Homo sapiens | Methylergometrine | - | chim(NtGi1-Go)/β1/γ2 | 2.75 | 2022-07-20 | doi.org/10.1038/s41594-022-00796-6 | |
| 8JLZ | A | Amine | 5-Hydroxytryptamine | 5-HT6 | Homo sapiens | ST1936 | - | Gs/β1/γ2 | 3.09 | 2023-06-28 | doi.org/10.1016/j.bbrc.2023.05.126 | |
| 7XTB | A | Amine | 5-Hydroxytryptamine | 5-HT6 | Homo sapiens | Serotonin | - | Gs/β1/γ2 | 3.3 | 2022-07-27 | doi.org/10.1016/j.molcel.2022.05.031 | |
| 7YS6 | A | Amine | 5-Hydroxytryptamine | 5-HT6 | Homo sapiens | Serotonin | - | chim(NtGi1-Gs)/β1/γ2 | 3 | 2023-03-29 | doi.org/10.1073/pnas.2209917120 | |
| 7XTC | A | Amine | 5-Hydroxytryptamine | 5-HT7 | Homo sapiens | 5-CT | - | Gs/β1/γ2 | 3.2 | 2022-07-27 | doi.org/10.1016/j.molcel.2022.05.031 | |
| 8FX5 | A | Amine | Acetylcholine (muscarinic) | M4 | Homo sapiens | Xanomeline | Xanomeline | Gi1/β1/γ2 | 2.45 | 2023-09-13 | doi.org/10.1038/s41467-023-41199-5 | |
| 7TRQ | A | Amine | Acetylcholine (muscarinic) | M4 | Homo sapiens | Iperoxo | VU0467154 | Gi1/β1/γ2 | 2.5 | 2023-05-17 | doi.org/10.2139/ssrn.4034884 | |
| 7V6A | A | Amine | Acetylcholine (muscarinic) | M4 | Homo sapiens | - | PubChem 9864275 | Gi1/β1/γ2 | 3.6 | 2022-05-11 | doi.org/10.1038/s41467-022-30595-y | |
| 7T94 | A | Amine | Acetylcholine (muscarinic) | M2 | Homo sapiens | Acetylcholine | LY2119620 | chim(NtGi1-Go)/β1/γ2 | 3.16 | 2023-01-25 | doi.org/10.1038/s41467-022-35726-z | |
| 6OIK | A | Amine | Acetylcholine (muscarinic) | M2 | Homo sapiens | Iperoxo | LY2119620 | chim(NtGi1-Go)/β1/γ2 | 3.6 | 2019-05-08 | doi.org/10.1126/science.aaw5188 | |
| 7T96 | A | Amine | Acetylcholine (muscarinic) | M2 | Homo sapiens | Acetylcholine | LY2119620 | Go/β1/γ2 | 3.22 | 2023-01-25 | doi.org/10.1038/s41467-022-35726-z | |
| 7V68 | A | Amine | Acetylcholine (muscarinic) | M4 | Homo sapiens | Iperoxo | LY2119620 | Gi1/β1/γ2 | 3.4 | 2022-05-11 | doi.org/10.1038/s41467-022-30595-y | |
| 7TRP | A | Amine | Acetylcholine (muscarinic) | M4 | Homo sapiens | Iperoxo | LY2033298 | Gi1/β1/γ2 | 2.4 | 2023-05-17 | doi.org/10.2139/ssrn.4034884 | |
| 6OIJ | A | Amine | Acetylcholine (muscarinic) | M1 | Homo sapiens | Iperoxo | - | chim(NtGi1L-G11)/β1/γ2 | 3.3 | 2019-05-08 | doi.org/10.1126/science.aaw5188 | |
| 7T8X | A | Amine | Acetylcholine (muscarinic) | M2 | Homo sapiens | Acetylcholine | - | chim(NtGi1-Go)/β1/γ2 | 3.21 | 2023-01-25 | doi.org/10.1038/s41467-022-35726-z | |
| 7T90 | A | Amine | Acetylcholine (muscarinic) | M2 | Homo sapiens | Acetylcholine | - | chim(NtGi1-Go)/β1/γ2 | 3.32 | 2023-01-25 | doi.org/10.1038/s41467-022-35726-z | |
| 8E9W | A | Amine | Acetylcholine (muscarinic) | M3 | Homo sapiens | 2-Deoxycytidine | - | chim(NtGi2L-Gs-CtGq)/β1/γ2 | 2.69 | 2022-11-30 | doi.org/10.1038/s41586-022-05489-0 | |
| 8E9Y | A | Amine | Acetylcholine (muscarinic) | M3 | Homo sapiens | Clozapine-N-oxide | - | chim(NtGi2L-Gs-CtGq)/β1/γ2 | 2.79 | 2022-11-30 | doi.org/10.1038/s41586-022-05489-0 | |
| 8E9Z | A | Amine | Acetylcholine (muscarinic) | M3 | Homo sapiens | Iperoxo | - | chim(NtGi2L-Gs-CtGq)/β1/γ2 | 2.69 | 2022-11-30 | doi.org/10.1038/s41586-022-05489-0 | |
| 7V69 | A | Amine | Acetylcholine (muscarinic) | M4 | Homo sapiens | - | - | Gi1/β1/γ2 | 3.4 | 2022-05-11 | doi.org/10.1038/s41467-022-30595-y | |
| 8E9X | A | Amine | Acetylcholine (muscarinic) | M4 | Homo sapiens | 2-Deoxycytidine | - | chim(NtGi1-Go)/β1/γ2 | 2.7 | 2022-11-30 | doi.org/10.1038/s41586-022-05489-0 | |
| 7TRK | A | Amine | Acetylcholine (muscarinic) | M4 | Homo sapiens | Iperoxo | - | Gi1/β1/γ2 | 2.8 | 2023-05-17 | doi.org/10.2139/ssrn.4034884 | |
| 7TRS | A | Amine | Acetylcholine (muscarinic) | M4 | Homo sapiens | Acetylcholine | - | Gi1/β1/γ2 | 2.8 | 2023-05-17 | doi.org/10.2139/ssrn.4034884 | |
| 7LD3 | A | Nucleotide | Adenosine | A1 | Homo sapiens | Adenosine | MIPS521 | Gi2/β1/γ2 | 3.2 | 2021-09-08 | doi.org/10.1038/s41586-021-03897-2 | |
| 6D9H | A | Nucleotide | Adenosine | A1 | Homo sapiens | Adenosine | - | Gi2/β1/γ2 | 3.6 | 2018-06-20 | doi.org/10.1038/s41586-018-0236-6 | |
| 7LD4 | A | Nucleotide | Adenosine | A1 | Homo sapiens | Adenosine | - | Gi2/β1/γ2 | 3.3 | 2021-09-08 | doi.org/10.1038/s41586-021-03897-2 | |
| 5G53 | A | Nucleotide | Adenosine | A2A | Homo sapiens | NECA | - | Gs | 3.4 | 2016-08-03 | doi.org/10.1038/nature18966 | |
| 6GDG | A | Nucleotide | Adenosine | A2A | Homo sapiens | NECA | - | Gs/β1/γ1 | 4.11 | 2018-05-16 | doi.org/10.7554/eLife.35946 | |
| 9EE8 | A | Nucleotide | Adenosine | A2A | Homo sapiens | Adenosine | - | Gs/β1/γ2 | 2.63 | 2025-04-09 | doi.org/10.1038/s41467-025-56434-4 | |
| 9EE9 | A | Nucleotide | Adenosine | A2A | Homo sapiens | Adenosine | - | Gs/β1/γ2 | 3.16 | 2025-04-09 | doi.org/10.1038/s41467-025-56434-4 | |
| 9EEA | A | Nucleotide | Adenosine | A2A | Homo sapiens | Adenosine | - | Gs/β1/γ2 | 3.36 | 2025-04-09 | doi.org/10.1038/s41467-025-56434-4 | |
| 8HDO | A | Nucleotide | Adenosine | A2B | Homo sapiens | BAY 60-6583 | - | Gs/β1/γ2 | 2.87 | 2023-01-18 | doi.org/10.1038/s41421-022-00503-1 | |
| 8HDP | A | Nucleotide | Adenosine | A2B | Homo sapiens | Adenosine | - | Gs/β1/γ2 | 3.2 | 2023-01-18 | doi.org/10.1038/s41421-022-00503-1 | |
| 7XY6 | A | Nucleotide | Adenosine | A2B | Homo sapiens | BAY 60-6583 | - | chim(NtGi1-Gs)/β1/γ2 | 2.99 | 2023-05-03 | doi.org/10.1126/sciadv.add3709 | |
| 7XY7 | A | Nucleotide | Adenosine | A2B | Homo sapiens | NECA | - | chim(NtGi1-Gs)/β1/γ2 | 3.26 | 2023-05-03 | doi.org/10.1126/sciadv.add3709 | |
| 8X16 | A | Nucleotide | Adenosine | A3A | Homo sapiens | Piclidenoson | - | Gi1/β1/γ2 | 3.29 | 2024-04-24 | doi.org/10.1038/s41467-024-47207-6 | |
| 8X17 | A | Nucleotide | Adenosine | A3A | Homo sapiens | Namodenoson | - | Gi1/β1/γ2 | 3.19 | 2024-04-24 | doi.org/10.1038/s41467-024-47207-6 | |
| 8YH0 | A | Nucleotide | Adenosine | A3A | Homo sapiens | NECA | - | Gi1/β1/γ2 | 2.86 | 2024-11-06 | doi.org/10.1038/s41467-024-53473-1 | |
| 8YH2 | A | Nucleotide | Adenosine | A3A | Homo sapiens | Adenosine | - | Gi1/β1/γ2 | 3.27 | 2024-11-06 | doi.org/10.1038/s41467-024-53473-1 | |
| 8YH3 | A | Nucleotide | Adenosine | A3A | Homo sapiens | N-methyladenosine | - | Gi1/β1/γ2 | 3.4 | 2024-11-06 | doi.org/10.1038/s41467-024-53473-1 | |
| 8YH5 | A | Nucleotide | Adenosine | A3A | Homo sapiens | Riboprine | - | Gi1/β1/γ2 | 3.66 | 2024-11-06 | doi.org/10.1038/s41467-024-53473-1 | |
| 8YH6 | A | Nucleotide | Adenosine | A3A | Homo sapiens | Namodenoson | - | Gi1/β1/γ2 | 3.62 | 2024-11-06 | doi.org/10.1038/s41467-024-53473-1 | |
| 8G2Y | B2 | Adhesion | Adhesion | ADGRF1 | Homo sapiens | - | LPC | chim(Gs-CtGq)/β1/γ2 | 3.44 | 2023-05-10 | doi.org/10.1038/s41467-023-38083-7 | |
| 7WU3 | B2 | Adhesion | Adhesion | ADGRF1 | Homo sapiens | - | K6G | Gs/β1/γ2 | 3.1 | 2022-04-27 | doi.org/10.1038/s41586-022-04580-w | |
| 7WU4 | B2 | Adhesion | Adhesion | ADGRF1 | Homo sapiens | - | K6G | Gi1/β1/γ2 | 3.4 | 2022-04-27 | doi.org/10.1038/s41586-022-04580-w | |
| 7WU5 | B2 | Adhesion | Adhesion | ADGRF1 | Homo sapiens | - | K6G | Gi1/β1/γ2 | 3 | 2022-04-27 | doi.org/10.1038/s41586-022-04580-w | |
| 7WU2 | B2 | Adhesion | Adhesion | ADGRD1 | Homo sapiens | - | - | Gs/β1/γ1 | 2.8 | 2022-04-27 | doi.org/10.1038/s41586-022-04580-w | |
| 7EPT | B2 | Adhesion | Adhesion | ADGRD1 | Homo sapiens | - | - | Gs/β1/γ2 | 3 | 2022-05-11 | doi.org/10.1038/s41586-022-04619-y | |
| 8X9S | B2 | Adhesion | Adhesion | ADGRD1 | Homo sapiens | 5α-DHT | - | chim(NtGi1-Gs)/β1/γ2 | 3.49 | 2025-02-12 | doi.org/10.1016/j.cell.2025.01.006 | |
| 8X9T | B2 | Adhesion | Adhesion | ADGRD1 | Homo sapiens | AP503 | - | chim(NtGi1-Gs)/β1/γ2 | 2.75 | 2025-02-12 | doi.org/10.1016/j.cell.2025.01.006 | |
| 8X9U | B2 | Adhesion | Adhesion | ADGRD1 | Homo sapiens | Metenolone | - | chim(NtGi1-Gs)/β1/γ2 | 2.88 | 2025-02-12 | doi.org/10.1016/j.cell.2025.01.006 | |
| 9IV1 | B2 | Adhesion | Adhesion | ADGRD1 | Homo sapiens | 5α-DHT | - | chim(NtGi1-Gs)/β1/γ2 | 2.98 | 2025-02-12 | doi.org/10.1016/j.cell.2025.01.006 | |
| 9IV2 | B2 | Adhesion | Adhesion | ADGRD1 | Homo sapiens | 5α-DHT | - | chim(NtGi1-Gs)/β1/γ2 | 3.53 | 2025-02-12 | doi.org/10.1016/j.cell.2025.01.006 | |
| 7YDH | B2 | Adhesion | Adhesion | ADGRE5 | Homo sapiens | - | - | chim(NtGi2-G13)/β1/γ2 | 3.1 | 2023-07-12 | doi.org/10.1016/j.chembiol.2023.08.003 | |
| 7YDM | B2 | Adhesion | Adhesion | ADGRE5 | Homo sapiens | - | - | chim(NtGi1-Gs-CtGq)/β1/γ2 | 2.89 | 2023-07-12 | doi.org/10.1016/j.chembiol.2023.08.003 | |
| 7YDP | B2 | Adhesion | Adhesion | ADGRE5 | Homo sapiens | - | - | chim(NtGi1-Gs)/β1/γ2 | 3.1 | 2023-07-12 | doi.org/10.1016/j.chembiol.2023.08.003 | |
| 8IKL | B2 | Adhesion | Adhesion | ADGRE5 | Homo sapiens | - | - | chim(NtGi1L-G13)/β1/γ2 | 2.33 | 2024-01-24 | doi.org/10.1016/j.molcel.2023.12.020 | |
| 7YDJ | B2 | Adhesion | Adhesion | ADGRE5 | Homo sapiens | - | - | chim(NtGi1-G12)/β1/γ2 | 3.03 | 2023-07-12 | To be published | |
| 7WXU | B2 | Adhesion | Adhesion | ADGRF1 | Homo sapiens | - | - | chim(NtGi1-Gs-CtGq)/β1/γ2 | 2.85 | 2022-09-28 | doi.org/10.1038/s41467-022-33173-4 | |
| 7WXW | B2 | Adhesion | Adhesion | ADGRF1 | Homo sapiens | - | - | chim(NtGi1-Gs)/β1/γ2 | 2.84 | 2022-09-28 | doi.org/10.1038/s41467-022-33173-4 | |
| 7WY0 | B2 | Adhesion | Adhesion | ADGRF1 | Homo sapiens | - | - | chim(NtGi1L-G13)/β1/γ2 | 2.83 | 2022-09-28 | doi.org/10.1038/s41467-022-33173-4 | |
| 7WZ7 | B2 | Adhesion | Adhesion | ADGRF1 | Homo sapiens | - | - | chim(NtGi1-G12)/β1/γ2 | 2.83 | 2022-09-28 | doi.org/10.1038/s41467-022-33173-4 | |
| 7X2V | B2 | Adhesion | Adhesion | ADGRF1 | Homo sapiens | - | - | Gi1/β1/γ2 | 3.09 | 2022-09-28 | doi.org/10.1038/s41467-022-33173-4 | |
| 7SF8 | B2 | Adhesion | Adhesion | ADGRG1 | Homo sapiens | - | - | chim(NtGi2-G13)/β1/γ2 | 2.7 | 2022-04-27 | doi.org/10.1038/s41586-022-04575-7 | |
| 7WUI | B2 | Adhesion | Adhesion | ADGRG2 | Mus musculus | IP15 | - | chim(NtGi1-Gs)/β1/γ2 | 3.1 | 2022-04-27 | doi.org/10.1038/s41586-022-04590-8 | |
| 7WUQ | B2 | Adhesion | Adhesion | ADGRG2 | Mus musculus | - | - | Gs/β1/γ2 | 2.9 | 2022-04-27 | doi.org/10.1038/s41586-022-04590-8 | |
| 7XKD | B2 | Adhesion | Adhesion | ADGRG2 | Mus musculus | β-Hydroxyandrosterone | - | Gs/β1/γ2 | 2.4 | 2022-08-10 | doi.org/10.1038/s41589-022-01084-6 | |
| 7XKE | B2 | Adhesion | Adhesion | ADGRG2 | Mus musculus | β-Hydroxyandrosterone | - | chim(NtGi1-Gs)/β1/γ2 | 2.9 | 2022-08-10 | doi.org/10.1038/s41589-022-01084-6 | |
| 7XKF | B2 | Adhesion | Adhesion | ADGRG2 | Mus musculus | β-Hydroxyandrosterone | - | Gs/β1/γ2 | 2.4 | 2022-08-10 | doi.org/10.1038/s41589-022-01084-6 | |
| 7YP7 | B2 | Adhesion | Adhesion | ADGRG2 | Mus musculus | - | - | Gs/β1/γ2 | 3.1 | 2022-08-24 | doi.org/10.1038/s41589-022-01084-6 | |
| 7D76 | B2 | Adhesion | Adhesion | ADGRG3 | Homo sapiens | Beclomethasone | - | Go/β1/γ2 | 3.1 | 2021-02-03 | doi.org/10.1038/s41586-020-03083-w | |
| 7D77 | B2 | Adhesion | Adhesion | ADGRG3 | Homo sapiens | Hydrocortisone | - | Go/β1/γ2 | 2.9 | 2021-02-03 | doi.org/10.1038/s41586-020-03083-w | |
| 7WUJ | B2 | Adhesion | Adhesion | ADGRG4 | Homo sapiens | - | - | chim(NtGi1-Gs)/β1/γ2 | 3.3 | 2022-04-27 | doi.org/10.1038/s41586-022-04590-8 | |
| 7EQ1 | B2 | Adhesion | Adhesion | ADGRG5 | Homo sapiens | - | - | chim(NtGi1-Gs)/β1/γ2 | 3.3 | 2022-05-11 | doi.org/10.1038/s41586-022-04619-y | |
| 7WY5 | B2 | Adhesion | Adhesion | ADGRL3 | Mus musculus | - | - | chim(NtGi1-Gs-CtGq)/β1/γ2 | 2.83 | 2022-10-26 | doi.org/10.1016/j.molcel.2022.10.009 | |
| 7WY8 | B2 | Adhesion | Adhesion | ADGRL3 | Mus musculus | - | - | chim(NtGi1-Gs)/β1/γ2 | 2.83 | 2022-10-26 | doi.org/10.1016/j.molcel.2022.10.009 | |
| 7WYB | B2 | Adhesion | Adhesion | ADGRL3 | Mus musculus | - | - | Gi1/β1/γ2 | 2.97 | 2022-10-26 | doi.org/10.1016/j.molcel.2022.10.009 | |
| 7X10 | B2 | Adhesion | Adhesion | ADGRL3 | Mus musculus | - | - | chim(NtGi1-G12)/β1/γ2 | 2.93 | 2022-10-26 | doi.org/10.1016/j.molcel.2022.10.009 | |
| 7SF7 | B2 | Adhesion | Adhesion | ADGRL3 | Homo sapiens | - | - | chim(NtGi2-G13)/β1/γ2 | 2.9 | 2022-04-27 | doi.org/10.1038/s41586-022-04575-7 | |
| 8UO1 | A | Amine | Adrenergic | β2 | Homo sapiens | Constrained Epinephrine | GTP; Mg | Gs/β1/γ2 | 3.6 | 2024-03-06 | doi.org/10.1038/s41586-024-07153-1 | |
| 8UO3 | A | Amine | Adrenergic | β2 | Homo sapiens | Constrained Epinephrine | GTP; Mg | Gs/β1/γ2 | 3.5 | 2024-03-06 | doi.org/10.1038/s41586-024-07153-1 | |
| 8UO4 | A | Amine | Adrenergic | β2 | Homo sapiens | Constrained Epinephrine | GTP; Mg | Gs/β1/γ2 | 4 | 2024-03-06 | doi.org/10.1038/s41586-024-07153-1 | |
| 8GFV | A | Amine | Adrenergic | β2 | Homo sapiens | Constrained Epinephrine | GTP | Gs/β1/γ2 | 3.1 | 2024-03-06 | doi.org/10.1038/s41586-024-07153-1 | |
| 8GFW | A | Amine | Adrenergic | β2 | Homo sapiens | Constrained Epinephrine | GTP | Gs/β1/γ2 | 3 | 2024-03-06 | doi.org/10.1038/s41586-024-07153-1 | |
| 8GFX | A | Amine | Adrenergic | β2 | Homo sapiens | Constrained Epinephrine | GTP | Gs/β1/γ2 | 3 | 2024-03-06 | doi.org/10.1038/s41586-024-07153-1 | |
| 8GFY | A | Amine | Adrenergic | β2 | Homo sapiens | Constrained Epinephrine | GTP | Gs/β1/γ2 | 3 | 2024-03-06 | doi.org/10.1038/s41586-024-07153-1 | |
| 8GFZ | A | Amine | Adrenergic | β2 | Homo sapiens | Constrained Epinephrine | GTP | Gs/β1/γ2 | 3 | 2024-03-06 | doi.org/10.1038/s41586-024-07153-1 | |
| 8GG0 | A | Amine | Adrenergic | β2 | Homo sapiens | Constrained Epinephrine | GTP | Gs/β1/γ2 | 2.9 | 2024-03-06 | doi.org/10.1038/s41586-024-07153-1 | |
| 8GG1 | A | Amine | Adrenergic | β2 | Homo sapiens | Constrained Epinephrine | GTP | Gs/β1/γ2 | 3 | 2024-03-06 | doi.org/10.1038/s41586-024-07153-1 | |
| 8GG2 | A | Amine | Adrenergic | β2 | Homo sapiens | Constrained Epinephrine | GTP | Gs/β1/γ2 | 3 | 2024-03-06 | doi.org/10.1038/s41586-024-07153-1 | |
| 8GG3 | A | Amine | Adrenergic | β2 | Homo sapiens | Constrained Epinephrine | GTP | Gs/β1/γ2 | 3.1 | 2024-03-06 | doi.org/10.1038/s41586-024-07153-1 | |
| 8GG4 | A | Amine | Adrenergic | β2 | Homo sapiens | Constrained Epinephrine | GTP | Gs/β1/γ2 | 3.2 | 2024-03-06 | doi.org/10.1038/s41586-024-07153-1 | |
| 8GG5 | A | Amine | Adrenergic | β2 | Homo sapiens | Constrained Epinephrine | GTP | Gs/β1/γ2 | 3.2 | 2024-03-06 | doi.org/10.1038/s41586-024-07153-1 | |
| 8GG6 | A | Amine | Adrenergic | β2 | Homo sapiens | Constrained Epinephrine | GTP | Gs/β1/γ2 | 3.3 | 2024-03-06 | doi.org/10.1038/s41586-024-07153-1 | |
| 8GG7 | A | Amine | Adrenergic | β2 | Homo sapiens | Constrained Epinephrine | GTP | Gs/β1/γ2 | 3.3 | 2024-03-06 | doi.org/10.1038/s41586-024-07153-1 | |
| 8GG8 | A | Amine | Adrenergic | β2 | Homo sapiens | Constrained Epinephrine | GTP | Gs/β1/γ2 | 3.3 | 2024-03-06 | doi.org/10.1038/s41586-024-07153-1 | |
| 8GG9 | A | Amine | Adrenergic | β2 | Homo sapiens | Constrained Epinephrine | GTP | Gs/β1/γ2 | 3.4 | 2024-03-06 | doi.org/10.1038/s41586-024-07153-1 | |
| 8GGA | A | Amine | Adrenergic | β2 | Homo sapiens | Constrained Epinephrine | GTP | Gs/β1/γ2 | 3.5 | 2024-03-06 | doi.org/10.1038/s41586-024-07153-1 | |
| 8GGB | A | Amine | Adrenergic | β2 | Homo sapiens | Constrained Epinephrine | GTP | Gs/β1/γ2 | 3.5 | 2024-03-06 | doi.org/10.1038/s41586-024-07153-1 | |
| 8GGC | A | Amine | Adrenergic | β2 | Homo sapiens | Constrained Epinephrine | GTP | Gs/β1/γ2 | 3.4 | 2024-03-06 | doi.org/10.1038/s41586-024-07153-1 | |
| 8GGE | A | Amine | Adrenergic | β2 | Homo sapiens | Constrained Epinephrine | GTP | Gs/β1/γ2 | 3.5 | 2024-03-06 | doi.org/10.1038/s41586-024-07153-1 | |
| 8GGF | A | Amine | Adrenergic | β2 | Homo sapiens | Constrained Epinephrine | GTP | Gs/β1/γ2 | 3.6 | 2024-03-06 | doi.org/10.1038/s41586-024-07153-1 | |
| 8UNL | A | Amine | Adrenergic | β2 | Homo sapiens | Constrained Epinephrine | GTP | Gs/β1/γ2 | 3.3 | 2024-03-06 | doi.org/10.1038/s41586-024-07153-1 | |
| 8UNM | A | Amine | Adrenergic | β2 | Homo sapiens | Constrained Epinephrine | GTP | Gs/β1/γ2 | 3.4 | 2024-03-06 | doi.org/10.1038/s41586-024-07153-1 | |
| 8UNN | A | Amine | Adrenergic | β2 | Homo sapiens | Constrained Epinephrine | GTP | Gs/β1/γ2 | 3.4 | 2024-03-06 | doi.org/10.1038/s41586-024-07153-1 | |
| 8UNO | A | Amine | Adrenergic | β2 | Homo sapiens | Constrained Epinephrine | GTP | Gs/β1/γ2 | 3.3 | 2024-03-06 | doi.org/10.1038/s41586-024-07153-1 | |
| 8UNP | A | Amine | Adrenergic | β2 | Homo sapiens | Constrained Epinephrine | GTP | Gs/β1/γ2 | 3.3 | 2024-03-06 | doi.org/10.1038/s41586-024-07153-1 | |
| 8UNQ | A | Amine | Adrenergic | β2 | Homo sapiens | Constrained Epinephrine | GTP | Gs/β1/γ2 | 3.3 | 2024-03-06 | doi.org/10.1038/s41586-024-07153-1 | |
| 8UNR | A | Amine | Adrenergic | β2 | Homo sapiens | Constrained Epinephrine | GTP | Gs/β1/γ2 | 3.4 | 2024-03-06 | doi.org/10.1038/s41586-024-07153-1 | |
| 8UNS | A | Amine | Adrenergic | β2 | Homo sapiens | Constrained Epinephrine | GTP | Gs/β1/γ2 | 3.4 | 2024-03-06 | doi.org/10.1038/s41586-024-07153-1 | |
| 8UNT | A | Amine | Adrenergic | β2 | Homo sapiens | Constrained Epinephrine | GTP | Gs/β1/γ2 | 3.4 | 2024-03-06 | doi.org/10.1038/s41586-024-07153-1 | |
| 8UNU | A | Amine | Adrenergic | β2 | Homo sapiens | Constrained Epinephrine | GTP | Gs/β1/γ2 | 3.5 | 2024-03-06 | doi.org/10.1038/s41586-024-07153-1 | |
| 8UNV | A | Amine | Adrenergic | β2 | Homo sapiens | Constrained Epinephrine | GTP | Gs/β1/γ2 | 3.3 | 2024-03-06 | doi.org/10.1038/s41586-024-07153-1 | |
| 8UNW | A | Amine | Adrenergic | β2 | Homo sapiens | Constrained Epinephrine | GTP | Gs/β1/γ2 | 3.4 | 2024-03-06 | doi.org/10.1038/s41586-024-07153-1 | |
| 8UNX | A | Amine | Adrenergic | β2 | Homo sapiens | Constrained Epinephrine | GTP | Gs/β1/γ2 | 3.6 | 2024-03-06 | doi.org/10.1038/s41586-024-07153-1 | |
| 8UNY | A | Amine | Adrenergic | β2 | Homo sapiens | Constrained Epinephrine | GTP | Gs/β1/γ2 | 3.6 | 2024-03-06 | doi.org/10.1038/s41586-024-07153-1 | |
| 8UNZ | A | Amine | Adrenergic | β2 | Homo sapiens | Constrained Epinephrine | GTP | Gs/β1/γ2 | 3.8 | 2024-03-06 | doi.org/10.1038/s41586-024-07153-1 | |
| 8UO0 | A | Amine | Adrenergic | β2 | Homo sapiens | Constrained Epinephrine | GTP | Gs/β1/γ2 | 3.5 | 2024-03-06 | doi.org/10.1038/s41586-024-07153-1 | |
| 8UO2 | A | Amine | Adrenergic | β2 | Homo sapiens | Constrained Epinephrine | GTP | Gs/β1/γ2 | 3.6 | 2024-03-06 | doi.org/10.1038/s41586-024-07153-1 | |
| 7YM8 | A | Amine | Adrenergic | Alpha1A | Homo sapiens | Oxymetazoline | - | chim(Gs-CtGq) | 2.92 | 2023-07-05 | doi.org/10.1038/s41467-023-39310-x | |
| 7YMH | A | Amine | Adrenergic | Alpha1A | Homo sapiens | Norepinephrine | - | chim(Gs-CtGq) | 3.52 | 2023-07-05 | doi.org/10.1038/s41467-023-39310-x | |
| 8THK | A | Amine | Adrenergic | Alpha1A | Homo sapiens | A61603 | - | chim(NtGi2L-Gs-CtGq)/β1/γ2 | 2.6 | 2023-08-16 | doi.org/10.1038/s41467-023-40524-2 | |
| 8THL | A | Amine | Adrenergic | Alpha1A | Homo sapiens | Epinephrine | - | chim(NtGi2L-Gs-CtGq)/β1/γ2 | 3.1 | 2023-08-16 | doi.org/10.1038/s41467-023-40524-2 | |
| 7EJ0 | A | Amine | Adrenergic | α2a | Homo sapiens | L-Norepinephrine | - | Go/β1/γ2 | 3.2 | 2022-04-13 | doi.org/10.1126/sciadv.abj5347 | |
| 7EJ8 | A | Amine | Adrenergic | α2a | Homo sapiens | Brimonidine | - | Go/β1/γ2 | 3 | 2022-04-13 | doi.org/10.1126/sciadv.abj5347 | |
| 7EJA | A | Amine | Adrenergic | α2a | Homo sapiens | Dexmedetomidine | - | Go/β1/γ2 | 3.6 | 2022-04-13 | doi.org/10.1126/sciadv.abj5347 | |
| 7EJK | A | Amine | Adrenergic | α2a | Homo sapiens | Oxymetazoline | - | Go/β1/γ2 | 3.4 | 2022-04-13 | doi.org/10.1126/sciadv.abj5347 | |
| 7W6P | A | Amine | Adrenergic | α2a | Homo sapiens | N-pyridin-4-ylisoquinolin-4-amine | - | Go/β1/γ2 | 3.47 | 2022-09-28 | doi.org/10.1126/science.abn7065 | |
| 7W7E | A | Amine | Adrenergic | α2a | Homo sapiens | PubChem 164946676 | - | Go/β1/γ2 | 3.4 | 2022-09-28 | doi.org/10.1126/science.abn7065 | |
| 9CBL | A | Amine | Adrenergic | α2a | Homo sapiens | Epinephrine | - | Gi1/β1/γ2 | 2.8 | 2024-09-11 | doi.org/10.1038/s12276-024-01296-x | |
| 9CBM | A | Amine | Adrenergic | α2a | Homo sapiens | Dexmedetomidine | - | Gi1/β1/γ2 | 3.2 | 2024-09-11 | doi.org/10.1038/s12276-024-01296-x | |
| 6K41 | A | Amine | Adrenergic | α2b | Homo sapiens | Dexmedetomidine | - | Go/β1/γ2 | 2.9 | 2020-04-15 | doi.org/10.1038/s41589-020-0492-2 | |
| 6K42 | A | Amine | Adrenergic | α2b | Homo sapiens | Dexmedetomidine | - | Gi1/β1/γ2 | 4.1 | 2020-04-15 | doi.org/10.1038/s41589-020-0492-2 | |
| 7JJO | A | Amine | Adrenergic | β1 | Meleagris gallopavo | Isoprenaline | - | Gs/β1/γ2 | 2.6 | 2020-09-02 | doi.org/10.1016/j.molcel.2020.08.001 | |
| 8DCR | A | Amine | Adrenergic | β1 | Meleagris gallopavo | Dobutamine | - | Gs/β1/γ2 | 2.6 | 2022-07-27 | doi.org/10.1038/s41467-022-31823-1 | |
| 8DCS | A | Amine | Adrenergic | β1 | Meleagris gallopavo | Cyanopindolol | - | Gs/β1/γ2 | 2.5 | 2022-07-27 | doi.org/10.1038/s41467-022-31823-1 | |
| 7S0F | A | Amine | Adrenergic | β1 | Meleagris gallopavo | Isoprenaline | - | Gi1/β1/γ2 | 2.96 | 2021-11-17 | doi.org/10.1038/s41594-021-00679-2 | |
| 7S0G | A | Amine | Adrenergic | β1 | Meleagris gallopavo | Isoprenaline | - | chim(Gi1-CtGs)/β1/γ2 | 3.86 | 2021-11-17 | doi.org/10.1038/s41594-021-00679-2 | |
| 8S2T | A | Amine | Adrenergic | β1 | Homo sapiens | Isoprenaline | - | chim(NtGi1-Gs)/β1/γ2 | 3.3 | 2025-05-21 | To be published | |
| 6E67 | A | Amine | Adrenergic | β2 | Homo sapiens | BI167107 | - | Gs(CT) | 3.7 | 2019-06-05 | doi.org/10.1016/j.cell.2019.04.021 | |
| 3SN6 | A | Amine | Adrenergic | β2 | Homo sapiens | BI167107 | - | Gs/β1/γ2 | 3.2 | 2011-07-20 | doi.org/10.1038/nature10361 | |
| 7BZ2 | A | Amine | Adrenergic | β2 | Homo sapiens | Arformoterol | - | Gs/β1/γ2 | 3.82 | 2020-08-05 | doi.org/10.1038/s41421-020-0176-9 | |
| 8GDZ | A | Amine | Adrenergic | β2 | Homo sapiens | Constrained Epinephrine | - | Gs/β1/γ2 | 3.5 | 2024-03-06 | doi.org/10.1038/s41586-024-07153-1 | |
| 8GE1 | A | Amine | Adrenergic | β2 | Homo sapiens | Constrained Epinephrine | - | Gs/β1/γ2 | 3.4 | 2024-03-06 | doi.org/10.1038/s41586-024-07153-1 | |
| 8GE3 | A | Amine | Adrenergic | β2 | Homo sapiens | Constrained Epinephrine | - | Gs/β1/γ2 | 3.3 | 2024-03-06 | doi.org/10.1038/s41586-024-07153-1 | |
| 8GE4 | A | Amine | Adrenergic | β2 | Homo sapiens | Constrained Epinephrine | - | Gs/β1/γ2 | 3.3 | 2024-03-06 | doi.org/10.1038/s41586-024-07153-1 | |
| 8GE6 | A | Amine | Adrenergic | β2 | Homo sapiens | Constrained Epinephrine | - | Gs/β1/γ2 | 3.4 | 2024-03-06 | doi.org/10.1038/s41586-024-07153-1 | |
| 8GE7 | A | Amine | Adrenergic | β2 | Homo sapiens | Constrained Epinephrine | - | Gs/β1/γ2 | 3.4 | 2024-03-06 | doi.org/10.1038/s41586-024-07153-1 | |
| 8GE8 | A | Amine | Adrenergic | β2 | Homo sapiens | Constrained Epinephrine | - | Gs/β1/γ2 | 3.4 | 2024-03-06 | doi.org/10.1038/s41586-024-07153-1 | |
| 8GE9 | A | Amine | Adrenergic | β2 | Homo sapiens | Constrained Epinephrine | - | Gs/β1/γ2 | 3.5 | 2024-03-06 | doi.org/10.1038/s41586-024-07153-1 | |
| 8GEA | A | Amine | Adrenergic | β2 | Homo sapiens | Constrained Epinephrine | - | Gs/β1/γ2 | 3.5 | 2024-03-06 | doi.org/10.1038/s41586-024-07153-1 | |
| 8GEB | A | Amine | Adrenergic | β2 | Homo sapiens | Constrained Epinephrine | - | Gs/β1/γ2 | 3.6 | 2024-03-06 | doi.org/10.1038/s41586-024-07153-1 | |
| 8GEC | A | Amine | Adrenergic | β2 | Homo sapiens | Constrained Epinephrine | - | Gs/β1/γ2 | 3.5 | 2024-03-06 | doi.org/10.1038/s41586-024-07153-1 | |
| 8GED | A | Amine | Adrenergic | β2 | Homo sapiens | Constrained Epinephrine | - | Gs/β1/γ2 | 3.5 | 2024-03-06 | doi.org/10.1038/s41586-024-07153-1 | |
| 8GEE | A | Amine | Adrenergic | β2 | Homo sapiens | Constrained Epinephrine | - | Gs/β1/γ2 | 3.7 | 2024-03-06 | doi.org/10.1038/s41586-024-07153-1 | |
| 8GEF | A | Amine | Adrenergic | β2 | Homo sapiens | Constrained Epinephrine | - | Gs/β1/γ2 | 3.8 | 2024-03-06 | doi.org/10.1038/s41586-024-07153-1 | |
| 8GEG | A | Amine | Adrenergic | β2 | Homo sapiens | Constrained Epinephrine | - | Gs/β1/γ2 | 3.8 | 2024-03-06 | doi.org/10.1038/s41586-024-07153-1 | |
| 8GEH | A | Amine | Adrenergic | β2 | Homo sapiens | Constrained Epinephrine | - | Gs/β1/γ2 | 4 | 2024-03-06 | doi.org/10.1038/s41586-024-07153-1 | |
| 8GEI | A | Amine | Adrenergic | β2 | Homo sapiens | Constrained Epinephrine | - | Gs/β1/γ2 | 4.1 | 2024-03-06 | doi.org/10.1038/s41586-024-07153-1 | |
| 8GEJ | A | Amine | Adrenergic | β2 | Homo sapiens | Constrained Epinephrine | - | Gs/β1/γ2 | 4.2 | 2024-03-06 | doi.org/10.1038/s41586-024-07153-1 | |
| 6NI3 | A | Amine | Adrenergic | β2 | Homo sapiens | BI167107 | - | Gs/β1/γ2 | 3.8 | 2019-11-20 | doi.org/10.1038/s41594-019-0330-y | |
| 7DHI | A | Amine | Adrenergic | β2 | Homo sapiens | Salbutamol | - | Gs/β1/γ2 | 3.26 | 2020-12-16 | doi.org/10.1093/nsr/nwaa284 | |
| 7DHR | A | Amine | Adrenergic | β2 | Homo sapiens | Isoprenaline | - | Gs/β1/γ2 | 3.8 | 2020-12-16 | doi.org/10.1093/nsr/nwaa284 | |
| 9BUY | A | Amine | Adrenergic | β2 | Homo sapiens | LM189 | - | Gi1/β1/γ2 | 2.9 | 2025-05-28 | doi.org/10.1126/sciadv.adq3971 | |
| 7XJI | A | Amine | Adrenergic | β3 | Canis lupus familiaris | Solabegron | - | Gs/β1/γ2 | 3.9 | 2022-05-04 | doi.org/10.1016/j.bbrc.2022.04.065 | |
| 7DH5 | A | Amine | Adrenergic | β3 | Canis lupus familiaris | Mirabegron | - | Gs/β1/γ2 | 3.16 | 2021-08-04 | doi.org/10.1016/j.molcel.2021.06.024 | |
| 7XJH | A | Amine | Adrenergic | β3 | Canis lupus familiaris | Isoproterenol | - | Gs/β1/γ2 | 3.3 | 2022-05-04 | doi.org/10.1016/j.molcel.2021.06.024 | |
| 9IJD | A | Amine | Adrenergic | β3 | Homo sapiens | Carazolol | - | chim(NtGi1-Gs)/β1/γ2 | 2.76 | 2024-08-21 | doi.org/10.1002/cplu.202400288 | |
| 9IJE | A | Amine | Adrenergic | β3 | Homo sapiens | Epinephrine | - | chim(NtGi1-Gs)/β1/γ2 | 2.34 | 2024-08-21 | doi.org/10.1002/cplu.202400288 | |
| 7F6G | A | Peptide | Angiotensin | AT1 | Homo sapiens | SAR1-AngII | - | Gq/β1/γ2 | 2.9 | 2023-03-29 | doi.org/10.15252/embj.2022112940 | |
| 8XZF | A | Peptide | Apelin | Apelin | Homo sapiens | WN561 | - | Gi1/β1/γ2 | 3 | 2024-03-20 | doi.org/10.1016/j.cell.2024.02.004 | |
| 8XZG | A | Peptide | Apelin | Apelin | Homo sapiens | Apelin-13 | - | Gi1/β1/γ2 | 3.2 | 2024-03-20 | doi.org/10.1016/j.cell.2024.02.004 | |
| 8XZH | A | Peptide | Apelin | Apelin | Homo sapiens | MM07 | - | Gi1/β1/γ2 | 2.06 | 2024-03-20 | doi.org/10.1016/j.cell.2024.02.004 | |
| 8XZJ | A | Peptide | Apelin | Apelin | Homo sapiens | WN353 | - | Gi1/β1/γ2 | 3 | 2024-03-20 | doi.org/10.1016/j.cell.2024.02.004 | |
| 8Z7J | A | Peptide | Apelin | Apelin | Homo sapiens | Agonistic antibody | - | Gi1/β1/γ2 | 3.12 | 2025-01-22 | doi.org/10.1038/s41467-024-55555-6 | |
| 7W0L | A | Peptide | Apelin | Apelin | Homo sapiens | PubChem 122701908 | - | Gi1/β1/γ2 | 3.57 | 2022-07-27 | doi.org/10.1038/s41594-022-00797-5 | |
| 7W0M | A | Peptide | Apelin | Apelin | Homo sapiens | PubChem 122701908 | - | Gi1/β1/γ2 | 3.71 | 2022-07-27 | doi.org/10.1038/s41594-022-00797-5 | |
| 7W0N | A | Peptide | Apelin | Apelin | Homo sapiens | Elabela | - | Gi1/β1/γ2 | 4.21 | 2022-07-27 | doi.org/10.1038/s41594-022-00797-5 | |
| 7W0O | A | Peptide | Apelin | Apelin | Homo sapiens | Elabela | - | Gi1/β1/γ2 | 3.78 | 2022-07-27 | doi.org/10.1038/s41594-022-00797-5 | |
| 7W0P | A | Peptide | Apelin | Apelin | Homo sapiens | Elabela | - | Gi1/β1/γ2 | 3.16 | 2022-07-27 | doi.org/10.1038/s41594-022-00797-5 | |
| 8XZI | A | Peptide | Apelin | Apelin | Homo sapiens | CMF-019 | - | Gi1/β1/γ2 | 2.7 | 2024-03-20 | doi.org/10.1016/j.cell.2024.02.004 | |
| 8XQE | A | Peptide | Apelin | Apelin | Homo sapiens | Apelin-13 | - | Gi1/β1/γ2 | 3.48 | 2025-01-22 | doi.org/10.1038/s41467-024-55555-6 | |
| 8XQF | A | Peptide | Apelin | Apelin | Homo sapiens | Apelin-13 | - | Gi1/β1/γ2 | 3.13 | 2025-01-22 | doi.org/10.1038/s41467-024-55555-6 | |
| 9JH3 | A | Peptide | Apelin | Apelin | Homo sapiens | CMF-019 | - | Gi1/β1/γ2 | 2.93 | 2025-04-23 | doi.org/10.1073/pnas.2423432122 | |
| 7BW0 | A | Steroid | Bile Acid | GPBA | Homo sapiens | - | - | chim(NtGi1-Gs)/β1/γ2 | 3.9 | 2020-09-02 | doi.org/10.1038/s41392-020-00262-z | |
| 7CFM | A | Steroid | Bile Acid | GPBA | Homo sapiens | P395 | - | Gs/β1/γ2 | 3 | 2020-09-09 | doi.org/10.1038/s41586-020-2569-1 | |
| 7CFN | A | Steroid | Bile Acid | GPBA | Homo sapiens | INT-777 | - | Gs/β1/γ2 | 3 | 2020-09-09 | doi.org/10.1038/s41586-020-2569-1 | |
| 7XTQ | A | Steroid | Bile Acid | GPBA | Homo sapiens | R399 | - | Gs/β1/γ2 | 3.2 | 2022-07-06 | doi.org/10.1073/pnas.2117054119 | |
| 9GYO | A | Steroid | Bile acid | GPBA | Homo sapiens | P395 | - | chim(NtGi1-Gs)/β1/γ2 | 2.5 | 2024-10-09 | To be published | |
| 8H0P | A | Peptide | Bombesin | BB1 | Homo sapiens | NMB30 | - | chim(NtGi1-Gs-CtGq)/β1/γ2 | 3.15 | 2023-08-09 | doi.org/10.1038/s41422-022-00743-6 | |
| 8H0Q | A | Peptide | Bombesin | BB2 | Homo sapiens | Gastrin Releasing Peptide | - | chim(NtGi1-Gs-CtGq)/β1/γ2 | 3.3 | 2023-08-09 | doi.org/10.1038/s41422-022-00743-6 | |
| 7W3Z | A | Peptide | Bombesin | BB2 | Homo sapiens | Gastrin Releasing Peptide | - | chim(NtGi1L-Gq)/β1/γ2 | 3 | 2023-02-22 | doi.org/10.1073/pnas.2216230120 | |
| 7W40 | A | Peptide | Bombesin | BB2 | Homo sapiens | Bombesin | - | chim(NtGi1L-Gq)/β1/γ2 | 3 | 2023-02-22 | doi.org/10.1073/pnas.2216230120 | |
| 8Y52 | A | Peptide | Bombesin | BB3 | Homo sapiens | BA1 | - | chim(NtGi1-Gs-CtGq)/β1/γ2 | 2.9 | 2024-09-11 | doi.org/10.1016/j.celrep.2024.114511 | |
| 8Y53 | A | Peptide | Bombesin | BB3 | Homo sapiens | MK5046 | - | chim(NtGi1-Gs-CtGq)/β1/γ2 | 2.93 | 2024-09-11 | doi.org/10.1016/j.celrep.2024.114511 | |
| 8Y51 | A | Peptide | Bombesin | BB3 | Homo sapiens | - | - | chim(NtGi1-Gs-CtGq)/β1/γ2 | 3.3 | 2025-02-12 | To be published | |
| 7EIB | A | Peptide | Bradykinin | BK1 | Homo sapiens | Des-Arg10-Kallidin | - | chim(NtGi1-Gs-CtGq)/β1/γ2 | 3 | 2021-10-13 | doi.org/10.1038/s41594-021-00645-y | |
| 7F6H | A | Peptide | Bradykinin | BK2 | Homo sapiens | Bradykinin | - | Gq/β1/γ2 | 2.9 | 2022-01-05 | doi.org/10.1038/s41467-022-28399-1 | |
| 7F6I | A | Peptide | Bradykinin | BK2 | Homo sapiens | Kallidin | - | Gq/β1/γ2 | 2.8 | 2022-01-05 | doi.org/10.1038/s41467-022-28399-1 | |
| 7F2O | A | Peptide | Bradykinin | BK2 | Homo sapiens | Bradykinin | - | chim(NtGi1-Gs-CtGq)/β1/γ2 | 2.9 | 2021-10-13 | doi.org/10.1038/s41594-021-00645-y | |
| 6NIY | B1 | Peptide | Calcitonin | CT | Homo sapiens | Adrenomedullin | - | Gs/β1/γ2 | 3.34 | 2019-01-23 | doi.org/10.1021/acsptsci.8b00056 | |
| 5UZ7 | B1 | Peptide | Calcitonin | CT | Homo sapiens | - | - | Gs/β1/γ2 | 4.1 | 2017-05-03 | doi.org/10.1038/nature22327 | |
| 8F0J | B1 | Peptide | Calcitonin | CT | Homo sapiens | Pramlintide Analogue San45 | - | Gs/β1/γ2 | 2 | 2023-08-02 | doi.org/10.1038/s41589-023-01393-4 | |
| 7TYL | B1 | Peptide | Calcitonin | CT | Homo sapiens | Amylin | - | Gs/β1/γ2 | 3.3 | 2022-03-23 | doi.org/10.1126/science.abm9609 | |
| 7TYO | B1 | Peptide | Calcitonin | CT | Homo sapiens | Calcitonin | - | Gs/β1/γ2 | 2.7 | 2022-03-23 | doi.org/10.1126/science.abm9609 | |
| 7TYI | B1 | Peptide | Calcitonin | CT | Homo sapiens | Amylin | - | Gs/β1/γ2 | 3.3 | 2022-03-30 | doi.org/10.1126/science.abm9609 | |
| 7TYN | B1 | Peptide | Calcitonin | CT | Homo sapiens | Calcitonin-1 | - | Gs/β1/γ2 | 2.6 | 2022-03-30 | doi.org/10.1126/science.abm9609 | |
| 9BUB | B1 | Peptide | Calcitonin | CT | Homo sapiens | Cagrilintide | - | Gs/β1/γ2 | 2.3 | 2025-04-23 | doi.org/10.1038/s41467-025-58680-y | |
| 9BLB | B1 | Peptide | Calcitonin | CT | Homo sapiens | Cagrilintide backbone (non-acylated) | - | Gs/β1/γ2 | 3.2 | 2025-04-16 | To be published | |
| 9BLC | B1 | Peptide | Calcitonin | CT | Homo sapiens | Cagrilintide backbone (non-acylated) | - | Gs/β1/γ2 | 3.3 | 2025-04-16 | To be published | |
| 9BUE | B1 | Peptide | Calcitonin | CT | Homo sapiens | Cagrilintide | - | Gs/β1/γ2 | 3.6 | 2025-04-16 | To be published | |
| 9BUC | B1 | Peptide | Calcitonin | CT | Homo sapiens | Cagrilintide | - | Gs/β1/γ2 | 3.4 | 2025-04-23 | To be published | |
| 9BUD | B1 | Peptide | Calcitonin | CT | Homo sapiens | Cagrilintide | - | Gs/β1/γ2 | 2.5 | 2025-04-23 | To be published | |
| 9AUC | B1 | Peptide | Calcitonin | CT (AMY1) | Homo sapiens | Calcitonin gene-related peptide-1 | - | Gs/β1/γ2; RAMP1 | 2.4 | 2024-04-24 | doi.org/10.1021/acs.biochem.4c00114 | |
| 7TYF | B1 | Peptide | Calcitonin | CT (AMY1) | Homo sapiens | Amylin | - | Gs/β1/γ2; RAMP1 | 2.2 | 2022-03-23 | doi.org/10.1126/science.abm9609 | |
| 7TYW | B1 | Peptide | Calcitonin | CT (AMY1) | Homo sapiens | Calcitonin-1 | - | Gs/β1/γ2; RAMP1 | 3 | 2022-03-23 | doi.org/10.1126/science.abm9609 | |
| 9BLW | B1 | Peptide | Calcitonin | CT (AMY1) | Homo sapiens | Cagrilintide backbone (non-acylated) | - | Gs/β1/γ2; RAMP1 | 3.2 | 2025-04-16 | To be published | |
| 9BP3 | B1 | Peptide | Calcitonin | CT (AMY1) | Homo sapiens | Cagrilintide | - | Gs/β1/γ2; RAMP1 | 2.2 | 2025-04-23 | To be published | |
| 7TYH | B1 | Peptide | Calcitonin | CT (AMY2) | Homo sapiens | Calcitonin-1 | - | Gs/β1/γ2; RAMP2 | 3.3 | 2022-03-23 | doi.org/10.1126/science.abm9609 | |
| 7TYY | B1 | Peptide | Calcitonin | CT (AMY2) | Homo sapiens | Calcitonin-1 | - | Gs/β1/γ2; RAMP2 | 3 | 2022-03-23 | doi.org/10.1126/science.abm9609 | |
| 7TYX | B1 | Peptide | Calcitonin | CT (AMY2) | Homo sapiens | Amylin | - | Gs/β1/γ2; RAMP2 | 2.55 | 2022-03-30 | doi.org/10.1126/science.abm9609 | |
| 9BQ3 | B1 | Peptide | Calcitonin | CT (AMY2) | Homo sapiens | Cagrilintide | - | Gs/β1/γ2; RAMP2 | 2.8 | 2025-04-23 | To be published | |
| 8F0K | B1 | Peptide | Calcitonin | CT (AMY3) | Homo sapiens | Pramlintide Analogue San385 | - | Gs/β1/γ2; RAMP3 | 1.9 | 2023-08-02 | doi.org/10.1038/s41589-023-01393-4 | |
| 8F2A | B1 | Peptide | Calcitonin | CT (AMY3) | Homo sapiens | Pramlintide Analogue San385 | - | Gs/β1/γ2; RAMP3 | 2.2 | 2023-08-02 | doi.org/10.1038/s41589-023-01393-4 | |
| 8F2B | B1 | Peptide | Calcitonin | CT (AMY3) | Homo sapiens | Pramlintide Analogue San45 | - | Gs/β1/γ2; RAMP3 | 2 | 2023-08-02 | doi.org/10.1038/s41589-023-01393-4 | |
| 7TZF | B1 | Peptide | Calcitonin | CT (AMY3) | Homo sapiens | Amylin | - | Gs/β1/γ2; RAMP3 | 2.4 | 2022-03-23 | doi.org/10.1126/science.abm9609 | |
| 9BTW | B1 | Peptide | Calcitonin | CT (AMY3) | Homo sapiens | Cagrilintide | - | Gs/β1/γ2; RAMP3 | 3 | 2025-04-16 | To be published | |
| 6E3Y | B1 | Peptide | Calcitonin | CT Like | Homo sapiens | Calcitonin gene-related peptide-1 | - | Gs/β1/γ2; RAMP1 | 3.3 | 2018-09-19 | doi.org/10.1038/s41586-018-0535-y | |
| 6UUN | B1 | Peptide | Calcitonin | CT Like (AM1) | Homo sapiens | Adrenomedullin | - | Gs/β1/γ2; RAMP2 | 3 | 2020-03-25 | doi.org/10.1021/acsptsci.9b00080 | |
| 6UUS | B1 | Peptide | Calcitonin | CT Like (AM2) | Homo sapiens | Adrenomedullin | - | Gs/β1/γ2; RAMP3 | 2.4 | 2020-04-01 | doi.org/10.1021/acsptsci.9b00080 | |
| 6UVA | B1 | Peptide | Calcitonin | CT Like (AM2) | Homo sapiens | Adrenomedullin-2 | - | Gs/β1/γ2; RAMP3 | 2.3 | 2020-04-01 | doi.org/10.1021/acsptsci.9b00080 | |
| 8WPU | C | Ion | Calcium Sensing | CaS | Homo sapiens | - | Tryptophan; Cinacalcet; PO4; Ca | chim(NtGi2L-Gs-CtGq)/β1/γ2 | 3.1 | 2023-11-22 | doi.org/10.1038/s41422-023-00892-2 | |
| 8SZG | C | Ion | Calcium Sensing | CaS | Homo sapiens | - | Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine | chim(NtGi1-Gq)/β1/γ2 | 3.6 | 2024-02-07 | doi.org/10.1038/s41586-024-07055-2 | |
| 8SZH | C | Ion | Calcium Sensing | CaS | Homo sapiens | - | Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine | Gi1/β1/γ2 | 3.1 | 2024-02-07 | doi.org/10.1038/s41586-024-07055-2 | |
| 8SZI | C | Ion | Calcium Sensing | CaS | Homo sapiens | - | Ca; Ca; Tryptophan; Cinacalcet; PO4 | Gi3/β1/γ2 | 3.5 | 2024-02-07 | doi.org/10.1038/s41586-024-07055-2 | |
| 9ASB | C | Ion | Calcium Sensing | CaS | Homo sapiens | Ca | Ca; Ca; Cyclomethyltryptophan; 9IG; PO4 | chim(NtGi1-Gs-CtGq)/β1/γ2 | 3.4 | 2024-04-17 | doi.org/10.1038/s41586-024-07331-1 | |
| 9AVG | C | Ion | Calcium Sensing | CaS | Homo sapiens | Ca | Ca; Ca; Cyclomethyltryptophan; 9IG; PO4 | chim(NtGi1-Gs)/β1/γ2 | 3.6 | 2024-04-17 | doi.org/10.1038/s41586-024-07331-1 | |
| 9AVL | C | Ion | Calcium Sensing | CaS | Homo sapiens | Ca | Ca; Ca; Cyclomethyltryptophan; 9IG; PO4 | Gi3/β2/γ2 | 3.8 | 2024-04-17 | doi.org/10.1038/s41586-024-07331-1 | |
| 9AXF | C | Ion | Calcium Sensing | CaS | Homo sapiens | Ca | Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4 | chim(NtGi1-Gs-CtGq)/β1/γ2 | 3.5 | 2024-04-17 | doi.org/10.1038/s41586-024-07331-1 | |
| 9AYF | C | Ion | Calcium Sensing | CaS | Homo sapiens | Ca | Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4 | Gi1/β1/γ2 | 3.6 | 2024-04-17 | doi.org/10.1038/s41586-024-07331-1 | |
| 7WV9 | A | Lipid | Cannabinoid | CB1 | Homo sapiens | CP55940 | ZCZ011 | Gi2/β1/γ2 | 3.36 | 2022-06-15 | doi.org/10.1038/s41589-022-01038-y | |
| 8IKH | A | Lipid | Cannabinoid | CB1 | Homo sapiens | - | Q2L | Gi1/β1/γ1 | 3.3 | 2024-06-05 | doi.org/10.1073/pnas.2321532121 | |
| 8IKG | A | Lipid | Cannabinoid | CB1 | Homo sapiens | - | Q2B | Gi1/β1/γ1 | 3.4 | 2024-06-05 | doi.org/10.1073/pnas.2321532121 | |
| 8K8J | A | Lipid | Cannabinoid | CB1 | Homo sapiens | Fenofibrate | - | chim(Gs-CtGq)/β1/γ2 | 2.88 | 2024-02-14 | doi.org/10.1002/advs.202306311 | |
| 6N4B | A | Lipid | Cannabinoid | CB1 | Homo sapiens | MDMB-Fubinaca | - | Gi1/β1/γ2 | 3 | 2019-01-30 | doi.org/10.1016/j.cell.2018.11.040 | |
| 6KPG | A | Lipid | Cannabinoid | CB1 | Homo sapiens | AM841 | - | Gi1/β1/γ2 | 3 | 2020-02-12 | doi.org/10.1016/j.cell.2020.01.008 | |
| 8GHV | A | Lipid | Cannabinoid | CB1 | Homo sapiens | AMG315 | - | Gi1/β1/γ2 | 2.8 | 2023-05-24 | doi.org/10.1038/s41467-023-37864-4 | |
| 9B54 | A | Lipid | Cannabinoid | CB1 | Homo sapiens | A1AIW | - | Gi1/β1/γ2 | 2.86 | 2025-03-05 | doi.org/10.1038/s41586-025-08618-7 | |
| 9B65 | A | Lipid | Cannabinoid | CB1 | Homo sapiens | KCA | - | Gi1/β1/γ2 | 3.03 | 2025-03-05 | doi.org/10.1038/s41586-025-08618-7 | |
| 9ERX | A | Lipid | Cannabinoid | CB1 | Homo sapiens | D9-THC analog | - | Gi1/β1/γ2 | 2.9 | 2024-06-26 | doi.org/10.21203/rs.3.rs-4277209/v1 | |
| 9EGO | A | Lipid | Cannabinoid | CB1 | Homo sapiens | YVF | - | Gi1/β1/γ2 | 3.2 | 2025-04-30 | doi.org/10.1038/s41467-025-57136-7 | |
| 8GAG | A | Lipid | Cannabinoid | CB1 | Homo sapiens | PubChem 170838490 | - | Gi1/β1/γ2 | 3.3 | 2024-02-28 | To be published | |
| 6PT0 | A | Lipid | Cannabinoid | CB2 | Homo sapiens | WIN 55212-2 | - | Gi1/β1/γ2 | 3.2 | 2020-02-12 | doi.org/10.1016/j.cell.2020.01.007 | |
| 6KPF | A | Lipid | Cannabinoid | CB2 | Homo sapiens | PubChem 145915889 | - | Gi1/β1/γ2 | 2.9 | 2020-02-12 | doi.org/10.1016/j.cell.2020.01.008 | |
| 8GUQ | A | Lipid | Cannabinoid | CB2 | Homo sapiens | Olorinab | - | Gi1/β1/γ2 | 3.08 | 2023-05-10 | doi.org/10.1038/s41467-023-37112-9 | |
| 8GUR | A | Lipid | Cannabinoid | CB2 | Homo sapiens | CP55,940 | - | Gi1/β1/γ2 | 2.84 | 2023-05-10 | doi.org/10.1038/s41467-023-37112-9 | |
| 8GUS | A | Lipid | Cannabinoid | CB2 | Homo sapiens | HU-308 | - | Gi1/β1/γ2 | 2.97 | 2023-05-10 | doi.org/10.1038/s41467-023-37112-9 | |
| 8GUT | A | Lipid | Cannabinoid | CB2 | Homo sapiens | LEI-102 | - | Gi1/β1/γ2 | 2.98 | 2023-05-10 | doi.org/10.1038/s41467-023-37112-9 | |
| 8X3L | A | Lipid | Cannabinoid | CB2 | Homo sapiens | XWD | - | Gi1/β1/γ2 | 3.13 | 2024-11-20 | doi.org/10.1073/pnas.2401091121 | |
| 7YKD | A | Protein | Chemerin | CML1 | Homo sapiens | Chemerin-9 | - | Gi1/β1/γ2 | 2.81 | 2023-04-19 | doi.org/10.1073/pnas.2214324120 | |
| 8SG1 | A | Protein | Chemerin | CML1 | Homo sapiens | Chemerin-9 | - | Gi1/β1/γ2 | 2.94 | 2023-11-01 | doi.org/10.1371/journal.pbio.3002188 | |
| 8ZJG | A | Protein | Chemerin | CML1 | Homo sapiens | Chemerin | - | Gi1/β1/γ2 | 3.18 | 2025-01-22 | doi.org/10.1038/s42003-024-07228-9 | |
| 9L3W | A | Protein | Chemerin | CML1 | Homo sapiens | Retinoic acid receptor responder protein 2 | - | Gi1/β1/γ2 | 3.5 | 2025-03-12 | doi.org/10.1093/procel/pwae073 | |
| 9L3Y | A | Protein | Chemerin | CML2 | Homo sapiens | Retinoic acid receptor responder protein 2 | - | Gi1/β1/γ2 | 3.6 | 2025-03-12 | doi.org/10.1093/procel/pwae073 | |
| 8JJP | A | Protein | Chemerin | CML2 | Homo sapiens | Chemerin | - | Gi1/β1/γ2 | 2.9 | 2024-08-21 | doi.org/10.1371/journal.pbio.3002838 | |
| 8XGM | A | Protein | Chemerin | CML2 | Homo sapiens | Chemerin | - | Gi1/β1/γ2 | 3.29 | 2024-08-21 | doi.org/10.1371/journal.pbio.3002838 | |
| 7VL8 | A | Protein | Chemokine | CCR1 | Homo sapiens | - | - | Gi1/β1/γ2 | 2.9 | 2022-03-23 | doi.org/10.1038/s41589-021-00918-z | |
| 7VL9 | A | Protein | Chemokine | CCR1 | Homo sapiens | CCL15(26-92) | - | Gi1/β1/γ2 | 2.6 | 2022-03-23 | doi.org/10.1038/s41589-021-00918-z | |
| 7VLA | A | Protein | Chemokine | CCR1 | Homo sapiens | CCL15(27-92) | - | Gi1/β1/γ2 | 2.7 | 2022-03-23 | doi.org/10.1038/s41589-021-00918-z | |
| 7XA3 | A | Protein | Chemokine | CCR2 | Homo sapiens | CCL2 | - | Gi1/β1/γ2 | 2.9 | 2022-08-24 | doi.org/10.1038/s41421-022-00403-4 | |
| 7X9Y | A | Protein | Chemokine | CCR3 | Homo sapiens | - | - | Gi1/β1/γ2 | 3.1 | 2022-08-24 | doi.org/10.1038/s41421-022-00403-4 | |
| 7F1Q | A | Protein | Chemokine | CCR5 | Homo sapiens | MIP-1a | - | Gi1/β1/γ2 | 2.9 | 2021-07-14 | doi.org/10.1038/s41467-021-24438-5 | |
| 7F1R | A | Protein | Chemokine | CCR5 | Homo sapiens | - | - | Gi1/β1/γ2 | 3 | 2021-07-14 | doi.org/10.1038/s41467-021-24438-5 | |
| 7F1S | A | Protein | Chemokine | CCR5 | Homo sapiens | - | - | Gi1/β1/γ2 | 2.8 | 2021-07-14 | doi.org/10.1038/s41467-021-24438-5 | |
| 7O7F | A | Protein | Chemokine | CCR5 | Homo sapiens | 6P4-CCL5 | - | Gi1/β1/γ1 | 3.15 | 2021-06-30 | doi.org/10.1126/sciadv.abg8685 | |
| 6WWZ | A | Protein | Chemokine | CCR6 | Homo sapiens | CCL20 | - | Go/β1/γ2 | 3.34 | 2020-06-24 | doi.org/10.1038/s41467-020-16820-6 | |
| 8U1U | A | Protein | Chemokine | CCR8 | Homo sapiens | CCL1 | - | Gi1/β1/γ2 | 3.1 | 2023-12-20 | doi.org/10.1038/s41467-023-43601-8 | |
| 8KFX | A | Protein | Chemokine | CCR8 | Homo sapiens | LMD-009 | - | Gi1/β1/γ2 | 2.96 | 2024-02-07 | doi.org/10.1126/sciadv.adj7500 | |
| 8KFY | A | Protein | Chemokine | CCR8 | Homo sapiens | ZK-756326 | - | Gi1/β1/γ2 | 3.06 | 2024-02-07 | doi.org/10.1126/sciadv.adj7500 | |
| 8KFZ | A | Protein | Chemokine | CCR8 | Homo sapiens | - | - | Gi1/β1/γ2 | 3.3 | 2024-02-07 | doi.org/10.1126/sciadv.adj7500 | |
| 8XML | A | Protein | Chemokine | CCR8 | Homo sapiens | - | - | Gi1/β1/γ2 | 2.58 | 2025-01-01 | To be published | |
| 7XBW | A | Protein | Chemokine | CX3CR1 | Homo sapiens | - | - | Gi1/β1/γ2 | 2.8 | 2022-07-13 | doi.org/10.1126/sciadv.abn8048 | |
| 7XBX | A | Protein | Chemokine | CX3CR1 | Homo sapiens | CX3CL1 | - | Gi1/β1/γ2 | 3.4 | 2022-07-13 | doi.org/10.1126/sciadv.abn8048 | |
| 8IC0 | A | Protein | Chemokine | CXCR1 | Homo sapiens | Interleukin-8 | - | Gi1/β1/γ2 | 3.41 | 2023-07-19 | doi.org/10.1038/s41467-023-39799-2 | |
| 6LFM | A | Protein | Chemokine | CXCR2 | Homo sapiens | Interleukin-8 | - | Gi1/β1/γ2 | 3.5 | 2020-09-02 | doi.org/10.1038/s41586-020-2492-5 | |
| 6LFO | A | Protein | Chemokine | CXCR2 | Homo sapiens | Interleukin-8 | - | Gi1/β1/γ2 | 3.4 | 2020-09-02 | doi.org/10.1038/s41586-020-2492-5 | |
| 8XWV | A | Protein | Chemokine | CXCR2 | Homo sapiens | CXCL1 | - | Go/β1/γ2 | 3.07 | 2025-01-15 | doi.org/10.1016/j.molcel.2025.01.024 | |
| 8XX3 | A | Protein | Chemokine | CXCR2 | Homo sapiens | CXCL3 | - | Go/β1/γ2 | 3.38 | 2025-01-15 | doi.org/10.1016/j.molcel.2025.01.024 | |
| 8XX6 | A | Protein | Chemokine | CXCR2 | Homo sapiens | CXCL8 | - | Go/β1/γ2 | 2.99 | 2025-01-15 | doi.org/10.1016/j.molcel.2025.01.024 | |
| 8XX7 | A | Protein | Chemokine | CXCR2 | Homo sapiens | CXCL5 | - | Go/β1/γ2 | 3.32 | 2025-01-15 | doi.org/10.1016/j.molcel.2025.01.024 | |
| 8XXH | A | Protein | Chemokine | CXCR2 | Homo sapiens | CXCL2 | - | Go/β1/γ2 | 2.8 | 2025-01-15 | doi.org/10.1016/j.molcel.2025.01.024 | |
| 8XXR | A | Protein | Chemokine | CXCR2 | Homo sapiens | - | - | Go/β1/γ2 | 3.17 | 2025-01-15 | doi.org/10.1016/j.molcel.2025.01.024 | |
| 8XXX | A | Protein | Chemokine | CXCR2 | Homo sapiens | CXCL6 | - | Go/β1/γ2 | 3.17 | 2025-01-15 | doi.org/10.1016/j.molcel.2025.01.024 | |
| 8HNK | A | Protein | Chemokine | CXCR3 | Homo sapiens | CXCL11 | - | Gi1/β1/γ2 | 3.01 | 2023-11-29 | doi.org/10.1038/s41594-023-01175-5 | |
| 8HNL | A | Protein | Chemokine | CXCR3 | Homo sapiens | PS372424 | - | Gi1/β1/γ2 | 2.98 | 2023-11-29 | doi.org/10.1038/s41594-023-01175-5 | |
| 8HNM | A | Protein | Chemokine | CXCR3 | Homo sapiens | VUF11222 | - | Gi1/β1/γ2 | 2.94 | 2023-11-29 | doi.org/10.1038/s41594-023-01175-5 | |
| 8K2X | A | Protein | Chemokine | CXCR3 | Homo sapiens | CXCL10 | - | Gi1/β1/γ2 | 3.2 | 2023-11-29 | doi.org/10.1038/s41594-023-01175-5 | |
| 8XXZ | A | Protein | Chemokine | CXCR3 | Homo sapiens | - | - | Go/β1/γ2 | 3.3 | 2025-02-26 | doi.org/10.1038/s41467-025-58264-w | |
| 8XYK | A | Protein | Chemokine | CXCR3 | Homo sapiens | VUF10661 | - | Go/β1/γ2 | 3.03 | 2025-02-26 | doi.org/10.1038/s41467-025-58264-w | |
| 8Y0N | A | Protein | Chemokine | CXCR3 | Homo sapiens | VUF11418 | - | Go/β1/γ2 | 3.07 | 2025-02-26 | doi.org/10.1038/s41467-025-58264-w | |
| 8U4N | A | Protein | Chemokine | CXCR4 | Homo sapiens | - | - | Gi1/β1/γ2 | 2.72 | 2024-03-13 | doi.org/10.1101/2024.02.09.579708 | |
| 8U4O | A | Protein | Chemokine | CXCR4 | Homo sapiens | CXCL12 | - | Gi1/β1/γ2 | 3.29 | 2024-03-13 | doi.org/10.1101/2024.02.09.579708 | |
| 8U4P | A | Protein | Chemokine | CXCR4 | Homo sapiens | AMD3100 | - | Gi1/β1/γ2 | 3.15 | 2024-03-13 | doi.org/10.1101/2024.02.09.579708 | |
| 8U4Q | A | Protein | Chemokine | CXCR4 | Homo sapiens | REGN7663-Fab | - | Gi1/β1/γ2 | 3.36 | 2024-03-13 | doi.org/10.1101/2024.02.09.579708 | |
| 8K3Z | A | Protein | Chemokine | CXCR4 | Homo sapiens | CXCL12 | - | Gi1/β1/γ1 | 2.81 | 2024-07-17 | doi.org/10.1016/j.celrep.2024.114578 | |
| 9AST | A | Protein | Chemokine | XCR1 | Homo sapiens | Lymphotactin | - | Gi1/β1/γ2 | 3.07 | 2024-12-11 | doi.org/10.1073/pnas.2405732121 | |
| 7XOU | A | Peptide | Cholecystokinin | CCKA | Homo sapiens | Cholecystokinin-8 | - | Gs/β1/γ2 | 3.2 | 2022-07-20 | doi.org/10.1038/s41421-022-00420-3 | |
| 7XOV | A | Peptide | Cholecystokinin | CCKA | Homo sapiens | SR146131 | - | Gs/β1/γ2 | 3 | 2022-07-20 | doi.org/10.1038/s41421-022-00420-3 | |
| 7EZH | A | Peptide | Cholecystokinin | CCKA | Homo sapiens | Cholecystokinin-8 | - | Gi1/β1/γ2 | 3.2 | 2021-08-25 | doi.org/10.1038/s41589-021-00841-3 | |
| 7EZK | A | Peptide | Cholecystokinin | CCKA | Homo sapiens | Cholecystokinin-8 | - | chim(NtGi1-Gs)/β1/γ2 | 3.1 | 2021-08-25 | doi.org/10.1038/s41589-021-00841-3 | |
| 7EZM | A | Peptide | Cholecystokinin | CCKA | Homo sapiens | Cholecystokinin-8 | - | chim(NtGsL-Gq)/β1/γ2 | 2.9 | 2021-08-25 | doi.org/10.1038/s41589-021-00841-3 | |
| 7MBX | A | Peptide | Cholecystokinin | CCKA | Homo sapiens | Cholecystokinin-8 | - | Gs/β1/γ1 | 1.95 | 2021-05-26 | doi.org/10.1371/journal.pbio.3001295 | |
| 7MBY | A | Peptide | Cholecystokinin | CCKA | Homo sapiens | Cholecystokinin-8 | - | chim(NtGi1L-Gs-CtGq)/β1/γ2 | 2.44 | 2021-05-26 | doi.org/10.1371/journal.pbio.3001295 | |
| 9BKJ | A | Peptide | Cholecystokinin | CCKA | Homo sapiens | Cholecystokinin-8 | - | chim(NtGi1-Gs-CtGq)/β1/γ2 | 2.59 | 2024-05-22 | doi.org/10.1371/journal.pbio.3002673 | |
| 9BKK | A | Peptide | Cholecystokinin | CCKA | Homo sapiens | Cholecystokinin-8 | - | chim(NtGi1-Gs-CtGq)/β1/γ2 | 2.51 | 2024-05-22 | doi.org/10.1371/journal.pbio.3002673 | |
| 7XOW | A | Peptide | Cholecystokinin | CCKB | Homo sapiens | Gastrin | - | chim(NtGi1-Gq)/β1/γ2 | 3.1 | 2022-07-20 | doi.org/10.1038/s41421-022-00420-3 | |
| 8IA7 | A | Peptide | Cholecystokinin | CCKB | Homo sapiens | Cholecystokinin-8 | - | chim(NtGi1L-Gq)/β1/γ2 | 3.1 | 2023-12-06 | doi.org/10.1038/s41421-022-00420-3 | |
| 7F8V | A | Peptide | Cholecystokinin | CCKB | Homo sapiens | Gastrin-17 | - | Gi2/β1/γ2 | 3.3 | 2021-10-13 | doi.org/10.1038/s41589-021-00866-8 | |
| 7F8W | A | Peptide | Cholecystokinin | CCKB | Homo sapiens | Gastrin-17 | - | chim(NtGsL-Gq)/β1/γ2 | 3.1 | 2021-10-13 | doi.org/10.1038/s41589-021-00866-8 | |
| 8I95 | A | Peptide | Complement Peptide | C3aB | Homo sapiens | EP54 | - | Go/β1/γ2 | 2.88 | 2023-10-18 | doi.org/10.1016/j.cell.2023.09.020 | |
| 8I97 | A | Peptide | Complement Peptide | C3aB | Homo sapiens | - | - | Go/β1/γ2 | 3.1 | 2023-10-18 | doi.org/10.1016/j.cell.2023.09.020 | |
| 8I9A | A | Peptide | Complement Peptide | C3aB | Homo sapiens | EP54 | - | chim(NtGi1-Gs-CtGq)/β1/γ2 | 3.57 | 2023-10-18 | doi.org/10.1016/j.cell.2023.09.020 | |
| 8I9L | A | Peptide | Complement Peptide | C3aB | Homo sapiens | C3a anaphylatoxin | - | Go/β1/γ2 | 3.18 | 2023-10-18 | doi.org/10.1016/j.cell.2023.09.020 | |
| 8I9S | A | Peptide | Complement Peptide | C3aB | Homo sapiens | - | - | Go/β1/γ2 | 3.26 | 2023-10-18 | doi.org/10.1016/j.cell.2023.09.020 | |
| 8J6D | A | Peptide | Complement Peptide | C3aB | Homo sapiens | EP141 | - | Go/β1/γ2 | 3.1 | 2023-10-18 | doi.org/10.1016/j.cell.2023.09.020 | |
| 8HK2 | A | Peptide | Complement Peptide | C3aB | Homo sapiens | C3a anaphylatoxin | - | Gi1/β1/γ2 | 2.9 | 2023-05-10 | doi.org/10.1038/s41589-023-01339-w | |
| 8HK3 | A | Peptide | Complement Peptide | C3aB | Homo sapiens | - | - | Gi1/β1/γ2 | 3.2 | 2023-05-10 | doi.org/10.1038/s41589-023-01339-w | |
| 8ZWG | A | Peptide | Complement Peptide | C3aB | Homo sapiens | JR14a | - | Gi1/β1/γ2 | 2.87 | 2025-05-14 | doi.org/10.1038/s41421-024-00765-x | |
| 9IPV | A | Peptide | Complement Peptide | C3aB | Homo sapiens | JR14a | - | Gi1/β1/γ2 | 2.53 | 2025-04-23 | doi.org/10.1038/s44318-025-00429-w | |
| 8IA8 | A | Peptide | Complement Peptide | C3aB | Homo sapiens | E7 peptide | - | Gi1/β1/γ2 | 2.86 | 2023-05-24 | To be published | |
| 8HPT | A | Peptide | Complement Peptide | C5a1 | Mus musculus | C5a anaphylatoxin C-terminal peptide | - | Go/β1/γ2 | 3.39 | 2023-10-18 | doi.org/10.1016/j.cell.2023.09.020 | |
| 8HQC | A | Peptide | Complement Peptide | C5a1 | Mus musculus | C5a anaphylatoxin | - | Go/β1/γ2 | 3.89 | 2023-10-18 | doi.org/10.1016/j.cell.2023.09.020 | |
| 8IA2 | A | Peptide | Complement Peptide | C5a1 | Homo sapiens | C5a anaphylatoxin | - | Go/β1/γ2 | 3.21 | 2023-10-18 | doi.org/10.1016/j.cell.2023.09.020 | |
| 8JZZ | A | Peptide | Complement Peptide | C5a1 | Homo sapiens | C5a-desArg | - | Go/β1/γ2 | 3.31 | 2023-10-18 | doi.org/10.1016/j.cell.2023.09.020 | |
| 7Y64 | A | Peptide | Complement Peptide | C5a1 | Homo sapiens | C5a anaphylatoxin | - | Gi1/β1/γ2 | 2.9 | 2023-03-01 | doi.org/10.1038/s41422-023-00779-2 | |
| 7Y65 | A | Peptide | Complement Peptide | C5a1 | Homo sapiens | C5a peptide | - | Gi1/β1/γ2 | 3.2 | 2023-03-01 | doi.org/10.1038/s41422-023-00779-2 | |
| 7Y66 | A | Peptide | Complement Peptide | C5a1 | Homo sapiens | BM213 | - | Gi1/β1/γ2 | 2.9 | 2023-03-01 | doi.org/10.1038/s41422-023-00779-2 | |
| 7Y67 | A | Peptide | Complement Peptide | C5a1 | Homo sapiens | C089 peptide | - | Gi1/β1/γ2 | 2.8 | 2023-03-01 | doi.org/10.1038/s41422-023-00779-2 | |
| 8HK5 | A | Peptide | Complement Peptide | C5a1 | Homo sapiens | Complement C5 | - | Gi1/β1/γ2 | 3 | 2023-05-10 | doi.org/10.1038/s41589-023-01339-w | |
| 8JZP | A | Peptide | Complement Peptide | C5a1 | Homo sapiens | C5A anaphylatoxin | - | Go/β1/γ2 | 3.54 | 2025-01-15 | To be published | |
| 6P9X | B1 | Peptide | Corticotropin Releasing Factor | CRF1 | Homo sapiens | Corticoliberin | - | Gs/β1/γ2 | 2.91 | 2020-02-05 | doi.org/10.1016/j.molcel.2020.01.012 | |
| 6PB0 | B1 | Peptide | Corticotropin Releasing Factor | CRF1 | Homo sapiens | Urocortin | - | chim(NtGi1-Gs)/β1/γ2 | 3 | 2020-02-12 | doi.org/10.1016/j.molcel.2020.01.013 | |
| 6PB1 | B1 | Peptide | Corticotropin Releasing Factor | CRF2 | Homo sapiens | Urocortin | - | chim(NtGi1-Gs)/β1/γ2 | 2.8 | 2020-02-12 | doi.org/10.1016/j.molcel.2020.01.013 | |
| 7TRY | B1 | Peptide | Corticotropin Releasing Factor | CRF2 | Homo sapiens | Urocortin | - | chim(NtGi1-G11)/β1/γ2 | 3.7 | 2022-11-09 | doi.org/10.1038/s41467-022-33851-3 | |
| 7TS0 | B1 | Peptide | Corticotropin Releasing Factor | CRF2 | Homo sapiens | Urocortin | - | chim(NtGi1L-Go)/β1/γ2 | 2.8 | 2022-11-09 | doi.org/10.1038/s41467-022-33851-3 | |
| 7CKZ | A | Amine | Dopamine | D1 | Homo sapiens | Dopamine | Mevidalen | Gs/β1/γ2 | 3.1 | 2021-03-03 | doi.org/10.1016/j.cell.2021.01.028 | |
| 7LJC | A | Amine | Dopamine | D1 | Homo sapiens | SKF-81297 | Mevidalen | Gs/β1/γ2 | 3 | 2021-03-03 | doi.org/10.1038/s41422-021-00482-0 | |
| 7LJD | A | Amine | Dopamine | D1 | Homo sapiens | Dopamine | Mevidalen | Gs/β1/γ1 | 3.2 | 2021-03-03 | doi.org/10.1038/s41422-021-00482-0 | |
| 7X2F | A | Amine | Dopamine | D1 | Homo sapiens | Dopamine | Mevidalen | Gs/β1/γ2 | 3 | 2022-06-15 | doi.org/10.1038/s41467-022-30929-w | |
| 7F1O | A | Amine | Dopamine | D1 | Homo sapiens | Dopamine | GDP; Mg | Gs/β1/γ2 | 3.13 | 2022-06-15 | doi.org/10.1126/sciadv.abo4158 | |
| 7F1Z | A | Amine | Dopamine | D1 | Homo sapiens | Dopamine | GDP | Gs/β1/γ2 | 3.46 | 2022-06-15 | doi.org/10.1126/sciadv.abo4158 | |
| 7F23 | A | Amine | Dopamine | D1 | Homo sapiens | Dopamine | GDP | Gs/β1/γ2 | 3.58 | 2022-06-15 | doi.org/10.1126/sciadv.abo4158 | |
| 7F24 | A | Amine | Dopamine | D1 | Homo sapiens | Dopamine | GDP | Gs/β1/γ2 | 4.16 | 2022-06-15 | doi.org/10.1126/sciadv.abo4158 | |
| 7X2C | A | Amine | Dopamine | D1 | Homo sapiens | Fenoldopam | Fenoldopam | Gs/β1/γ2 | 3.2 | 2022-06-29 | doi.org/10.1038/s41467-022-30929-w | |
| 7JV5 | A | Amine | Dopamine | D1 | Homo sapiens | SKF81297 | - | Gs/β1/γ2 | 3 | 2021-02-24 | doi.org/10.1016/j.cell.2021.01.027 | |
| 7JVP | A | Amine | Dopamine | D1 | Homo sapiens | SKF83959 | - | Gs/β1/γ2 | 2.9 | 2021-02-24 | doi.org/10.1016/j.cell.2021.01.027 | |
| 7JVQ | A | Amine | Dopamine | D1 | Homo sapiens | Apomorphine | - | Gs/β1/γ2 | 3 | 2021-02-24 | doi.org/10.1016/j.cell.2021.01.027 | |
| 7CKW | A | Amine | Dopamine | D1 | Homo sapiens | Fenoldopam | - | Gs/β1/γ2 | 3.22 | 2021-03-03 | doi.org/10.1016/j.cell.2021.01.028 | |
| 7CKX | A | Amine | Dopamine | D1 | Homo sapiens | A77636 | - | Gs/β1/γ2 | 3.54 | 2021-03-03 | doi.org/10.1016/j.cell.2021.01.028 | |
| 7CKY | A | Amine | Dopamine | D1 | Homo sapiens | PW0464 | - | Gs/β1/γ2 | 3.2 | 2021-03-03 | doi.org/10.1016/j.cell.2021.01.028 | |
| 7CRH | A | Amine | Dopamine | D1 | Homo sapiens | SKF83959 | - | Gs/β1/γ2 | 3.3 | 2021-03-03 | doi.org/10.1016/j.cell.2021.01.028 | |
| 8IRR | A | Amine | Dopamine | D1 | Homo sapiens | Rotigotine | - | Gs/β1/γ2 | 3.2 | 2023-06-07 | doi.org/10.1038/s41422-023-00808-0 | |
| 7JOZ | A | Amine | Dopamine | D1 | Homo sapiens | VFP | - | Gs/β1/γ2 | 3.8 | 2021-04-14 | doi.org/10.1038/s41467-021-23519-9 | |
| 7X2D | A | Amine | Dopamine | D1 | Homo sapiens | Tavapadon | - | Gs/β1/γ2 | 3.3 | 2022-06-15 | doi.org/10.1038/s41467-022-30929-w | |
| 7F0T | A | Amine | Dopamine | D1 | Homo sapiens | Dopamine | - | Gs/β1/γ2 | 3.1 | 2022-06-15 | doi.org/10.1126/sciadv.abo4158 | |
| 7JVR | A | Amine | Dopamine | D2 | Homo sapiens | Bromoergocryptine | - | Gi1/β1/γ2 | 2.8 | 2021-02-24 | doi.org/10.1016/j.cell.2021.01.027 | |
| 8IRS | A | Amine | Dopamine | D2 | Homo sapiens | Rotigotine | - | Gi1/β1/γ2 | 3 | 2023-06-07 | doi.org/10.1038/s41422-023-00808-0 | |
| 6VMS | A | Amine | Dopamine | D2 | Homo sapiens | Bromoergocryptine | - | Gi1/β1/γ2 | 3.8 | 2020-06-17 | doi.org/10.1038/s41586-020-2379-5 | |
| 8TZQ | A | Amine | Dopamine | D2 | Homo sapiens | L-Dopamine | - | Go/β1/γ2 | 3.2 | 2024-08-21 | doi.org/10.1038/s41467-024-50964-z | |
| 8U02 | A | Amine | Dopamine | D2 | Homo sapiens | L-Dopamine | - | Go/β1/γ2 | 3.28 | 2024-08-21 | doi.org/10.1038/s41467-024-50964-z | |
| 7CMU | A | Amine | Dopamine | D3 | Homo sapiens | Pramipexole | - | Gi1/β1/γ2 | 3 | 2021-03-10 | doi.org/10.1016/j.molcel.2021.01.003 | |
| 7CMV | A | Amine | Dopamine | D3 | Homo sapiens | PD128907 | - | Gi1/β1/γ2 | 2.7 | 2021-03-10 | doi.org/10.1016/j.molcel.2021.01.003 | |
| 8IRT | A | Amine | Dopamine | D3 | Homo sapiens | Rotigotine | - | Gi1/β1/γ2 | 2.7 | 2023-06-07 | doi.org/10.1038/s41422-023-00808-0 | |
| 9F33 | A | Amine | Dopamine | D3 | Homo sapiens | FOB02-04A | - | Go/β1/γ2 | 3.05 | 2024-09-18 | doi.org/10.1038/s41467-024-51993-4 | |
| 9F34 | A | Amine | Dopamine | D3 | Homo sapiens | FOB02-04A | - | Go/β1/γ2 | 3.05 | 2024-09-18 | doi.org/10.1038/s41467-024-51993-4 | |
| 8IRU | A | Amine | Dopamine | D4 | Homo sapiens | Rotigotine | - | chim(NtGi1-Gs-CtGi1)/β1/γ2 | 3.2 | 2023-06-07 | doi.org/10.1038/s41422-023-00808-0 | |
| 8IRV | A | Amine | Dopamine | D5 | Homo sapiens | Rotigotine | - | chim(NtGi1-Gs)/β1/γ2 | 3.1 | 2023-06-07 | doi.org/10.1038/s41422-023-00808-0 | |
| 8HCQ | A | Peptide | Endothelin | ETA | Homo sapiens | Endothelin-1 | - | chim(NtGi1-Gs-CtGq)/β1/γ2 | 3.01 | 2023-03-22 | doi.org/10.1038/s41467-023-36998-9 | |
| 8XVI | A | Peptide | Endothelin | ETA | Homo sapiens | Endothelin-1 | - | chim(Gs-CtGq)/β1/γ2 | 3.32 | 2024-08-28 | doi.org/10.1038/s41421-024-00705-9 | |
| 8HBD | A | Peptide | Endothelin | ETB | Homo sapiens | IRL1620 | - | Gi1/β1/γ2 | 2.99 | 2023-03-22 | doi.org/10.1038/s41467-023-36998-9 | |
| 8HCX | A | Peptide | Endothelin | ETB | Homo sapiens | Endothelin-1 | - | chim(NtGi2L-Gs-CtGq)/β1/γ2 | 3.5 | 2023-03-22 | doi.org/10.1038/s41467-023-36998-9 | |
| 8IY5 | A | Peptide | Endothelin | ETB | Homo sapiens | Endothelin-1 | - | Gi1/β1/γ2 | 2.8 | 2023-08-16 | doi.org/10.7554/eLife.85821 | |
| 8XVE | A | Peptide | Endothelin | ETB | Homo sapiens | BQ3020 | - | chim(Gs-CtGq)/β1/γ2 | 3 | 2024-08-28 | doi.org/10.1038/s41421-024-00705-9 | |
| 8XVH | A | Peptide | Endothelin | ETB | Homo sapiens | Endothelin-1 | - | chim(Gs-CtGq)/β1/γ2 | 3.26 | 2024-08-28 | doi.org/10.1038/s41421-024-00705-9 | |
| 8XWP | A | Peptide | Endothelin | ETB | Homo sapiens | Endothelin-1 | - | Gi1/β1/γ2 | 3.21 | 2024-10-02 | doi.org/10.1038/s42003-024-06905-z | |
| 8XWQ | A | Peptide | Endothelin | ETB | Homo sapiens | Endothelin-1 | - | Gi1/β1/γ2 | 4.6 | 2024-10-02 | doi.org/10.1038/s42003-024-06905-z | |
| 7T6T | A | Peptide | Formylpeptide | FPR1-ALX | Homo sapiens | fMLFII | - | Gi1/β1/γ2 | 3.2 | 2022-03-30 | doi.org/10.1038/s41467-022-28586-0 | |
| 7WVU | A | Peptide | Formylpeptide | FPR1-ALX | Homo sapiens | fMLF | - | Gi1/β1/γ2 | 3.3 | 2022-04-13 | doi.org/10.1038/s41467-022-29361-x | |
| 7EUO | A | Peptide | Formylpeptide | FPR1-ALX | Homo sapiens | fMLF | - | Gi1/β1/γ2 | 2.9 | 2022-05-25 | doi.org/10.1038/s41467-022-32822-y | |
| 7VFX | A | Peptide | Formylpeptide | FPR1-ALX | Homo sapiens | fMLF | - | Gi1/β1/γ2 | 2.8 | 2022-09-21 | doi.org/10.1038/s41467-022-32822-y | |
| 6OMM | A | Peptide | Formylpeptide | FPR2-ALX | Homo sapiens | WKYMVX | - | Gi1/β1/γ2 | 3.17 | 2020-02-26 | doi.org/10.1038/s41467-020-14728-9 | |
| 7T6S | A | Peptide | Formylpeptide | FPR2-ALX | Homo sapiens | PubChem 24776341 | - | Gi1/β1/γ2 | 3 | 2022-03-30 | doi.org/10.1038/s41467-022-28586-0 | |
| 7T6U | A | Peptide | Formylpeptide | FPR2-ALX | Homo sapiens | CGEN-855A | - | Gi1/β1/γ2 | 2.9 | 2022-03-30 | doi.org/10.1038/s41467-022-28586-0 | |
| 7T6V | A | Peptide | Formylpeptide | FPR2-ALX | Homo sapiens | fMLFII | - | Gi1/β1/γ2 | 3.1 | 2022-03-30 | doi.org/10.1038/s41467-022-28586-0 | |
| 7WVV | A | Peptide | Formylpeptide | FPR2-ALX | Homo sapiens | fMLFII | - | Gi2/β1/γ2 | 2.9 | 2022-04-13 | doi.org/10.1038/s41467-022-29361-x | |
| 7WVW | A | Peptide | Formylpeptide | FPR2-ALX | Homo sapiens | fMYFINILTL | - | Gi2/β1/γ2 | 3.1 | 2022-04-13 | doi.org/10.1038/s41467-022-29361-x | |
| 7WVX | A | Peptide | Formylpeptide | FPR2-ALX | Homo sapiens | Humanin | - | Gi2/β1/γ2 | 2.8 | 2022-04-13 | doi.org/10.1038/s41467-022-29361-x | |
| 7WVY | A | Peptide | Formylpeptide | FPR2-ALX | Homo sapiens | Amyloid-β42 | - | Gi2/β1/γ2 | 3 | 2022-04-13 | doi.org/10.1038/s41467-022-29361-x | |
| 8Y62 | A | Peptide | Formylpeptide | FPR2-ALX | Homo sapiens | C16:0 Ceramide | - | Gi1/β1/γ2 | 3.2 | 2025-02-05 | doi.org/10.1126/science.ado4188 | |
| 8Y63 | A | Peptide | Formylpeptide | FPR2-ALX | Homo sapiens | C20:0 Ceramide | - | Gi1/β1/γ2 | 3.2 | 2025-02-05 | doi.org/10.1126/science.ado4188 | |
| 9JHJ | A | Peptide | Formylpeptide | FPR2-ALX | Homo sapiens | C18:0 Ceramide | - | Gi1/β1/γ2 | 3.2 | 2025-03-19 | doi.org/10.1126/science.ado4188 | |
| 8IYS | A | Lipid | Free Fatty Acid | FFA4 | Homo sapiens | TUG-891 | GDP | chim(NtGi1L-Gq)/β1/γ2 | 2.95 | 2023-06-21 | doi.org/10.1038/s41422-023-00835-x | |
| 9K1C | A | Lipid | Free Fatty Acid | FFA1 | Homo sapiens | - | DHA | Gi1/β1/γ2 | 3.2 | 2024-12-11 | doi.org/10.1016/j.celrep.2024.115024 | |
| 9CM3 | A | Lipid | Free Fatty Acid | FFA2 | Homo sapiens | TUG-1375 | Compound 187 | chim(NtGi1L-Gs-CtGq)/β1/γ2 | 3.06 | 2025-06-25 | doi.org/10.1038/s41586-025-09186-6 | |
| 9NS9 | A | Lipid | Free Fatty Acid | FFA2 | Homo sapiens | TUG-1375 | Compound 187 | Gi1/β1/γ2 | 3.3 | 2025-06-25 | doi.org/10.1038/s41586-025-09186-6 | |
| 9CM7 | A | Lipid | Free Fatty Acid | FFA2 | Homo sapiens | TUG-1375 | AZ-1729 | Gi1/β1/γ2 | 3.29 | 2025-06-25 | doi.org/10.1038/s41586-025-09186-6 | |
| 8J20 | A | Lipid | Free Fatty Acid | FFA3 | Homo sapiens | Valeric acid | AR420626 | Gi1/β1/γ2 | 3.2 | 2024-01-24 | doi.org/10.1038/s41422-023-00914-z | |
| 8Y6W | A | Lipid | Free Fatty Acid | FFA2 | Homo sapiens | TUG-1375 | 4-CMTB | Gi1/β1/γ2 | 3.19 | 2025-04-02 | doi.org/10.1038/s41467-025-57983-4 | |
| 9CLW | A | Lipid | Free Fatty Acid | FFA2 | Homo sapiens | TUG-1375 | 4-CMTB | chim(NtGi1L-Gs-CtGq)/β1/γ2 | 3.19 | 2025-06-25 | doi.org/10.1038/s41586-025-09186-6 | |
| 8EIT | A | Lipid | Free Fatty Acid | FFA1 | Homo sapiens | Doconexent | - | chim(NtGi1L-Gs-CtGq)/β1/γ2 | 2.8 | 2023-05-24 | doi.org/10.1073/pnas.2219569120 | |
| 8EJC | A | Lipid | Free Fatty Acid | FFA1 | Homo sapiens | TAK-875 | - | chim(NtGi1L-Gs-CtGq)/β1/γ2 | 3 | 2023-05-24 | doi.org/10.1073/pnas.2219569120 | |
| 8EJK | A | Lipid | Free Fatty Acid | FFA1 | Homo sapiens | TAK-875 | - | chim(NtGi1L-Gs-CtGq)/β1/γ2 | 3.4 | 2023-05-24 | doi.org/10.1073/pnas.2219569120 | |
| 8T3V | A | Lipid | Free Fatty Acid | FFA1 | Homo sapiens | Docosa-4,7,10,13,16,19-Hexaenoic acid | - | chim(NtGi2L-Gs-CtGq)/β1/γ2 | 3.39 | 2024-01-24 | doi.org/10.1126/sciadv.adj2384 | |
| 9K1D | A | Lipid | Free Fatty Acid | FFA2 | Homo sapiens | Butanoic acid | - | Gi1/β1/γ2 | 3.34 | 2024-12-11 | doi.org/10.1016/j.celrep.2024.115024 | |
| 8J22 | A | Lipid | Free Fatty Acid | FFA2 | Homo sapiens | TUG-1375 | - | Gi1/β1/γ2 | 3.2 | 2024-01-24 | doi.org/10.1038/s41422-023-00914-z | |
| 8J24 | A | Lipid | Free Fatty Acid | FFA2 | Homo sapiens | Acetic acid | - | Gi1/β1/γ2 | 2.6 | 2024-01-24 | doi.org/10.1038/s41422-023-00914-z | |
| 8T3S | A | Lipid | Free Fatty Acid | FFA2 | Homo sapiens | Butyric acid | - | chim(NtGi2L-Gs-CtGq)/β1/γ2 | 3.07 | 2024-01-24 | doi.org/10.1126/sciadv.adj2384 | |
| 8J23 | A | Lipid | Free Fatty Acid | FFA2 | Homo sapiens | - | - | Gi1/β1/γ2 | 3.2 | 2024-04-17 | To be published | |
| 8J21 | A | Lipid | Free Fatty Acid | FFA3 | Homo sapiens | Butyric acid | - | Gi1/β1/γ2 | 3.3 | 2024-01-24 | doi.org/10.1038/s41422-023-00914-z | |
| 8H4I | A | Lipid | Free Fatty Acid | FFA4 | Homo sapiens | Doconexent | - | chim(NtGi1-Gs)/β1/γ2 | 3.06 | 2023-06-21 | doi.org/10.1038/s41422-023-00835-x | |
| 8H4K | A | Lipid | Free Fatty Acid | FFA4 | Homo sapiens | GW9508 | - | chim(NtGi1-Gs-CtGq)/β1/γ2 | 3.1 | 2023-06-21 | doi.org/10.1038/s41422-023-00835-x | |
| 8H4L | A | Lipid | Free Fatty Acid | FFA4 | Homo sapiens | Doconexent | - | chim(NtGi1-Gs-CtGq)/β1/γ2 | 3.07 | 2023-06-21 | doi.org/10.1038/s41422-023-00835-x | |
| 8T3O | A | Lipid | Free Fatty Acid | FFA4 | Homo sapiens | TUG-891 | - | chim(NtGi2L-Gs-CtGq)/β1/γ2 | 3.06 | 2024-01-17 | doi.org/10.1126/sciadv.adj2384 | |
| 8T3Q | A | Lipid | Free Fatty Acid | FFA4 | Homo sapiens | Docosa-4,7,10,13,16,19-Hexaenoic acid | - | chim(NtGi2L-Gs-CtGq)/β1/γ2 | 3.14 | 2024-01-24 | doi.org/10.1126/sciadv.adj2384 | |
| 8G59 | A | Lipid | Free Fatty Acid | FFA4 | Homo sapiens | TUG-891 | - | chim(Gi1-CtGq)/β1/γ2 | 2.64 | 2023-03-08 | doi.org/10.1126/science.add6220 | |
| 8ID3 | A | Lipid | Free Fatty Acid | FFA4 | Homo sapiens | 9-Hydroxystearic acid | - | Gi1/β1/γ2 | 3.1 | 2023-03-15 | doi.org/10.1126/science.add6220 | |
| 8ID4 | A | Lipid | Free Fatty Acid | FFA4 | Homo sapiens | Linoleic acid | - | Gi1/β1/γ2 | 3.1 | 2023-03-15 | doi.org/10.1126/science.add6220 | |
| 8ID6 | A | Lipid | Free Fatty Acid | FFA4 | Homo sapiens | Oleic acid | - | Gi1/β1/γ2 | 2.8 | 2023-03-15 | doi.org/10.1126/science.add6220 | |
| 8ID8 | A | Lipid | Free Fatty Acid | FFA4 | Homo sapiens | TUG-891 | - | Gi1/β1/γ2 | 3 | 2023-03-15 | doi.org/10.1126/science.add6220 | |
| 8ID9 | A | Lipid | Free Fatty Acid | FFA4 | Homo sapiens | Eicosapentaenoic acid | - | Gi1/β1/γ2 | 3 | 2023-03-15 | doi.org/10.1126/science.add6220 | |
| 6XBJ | F | Protein | Frizzled | SMO | Homo sapiens | - | Cholesterol | Gi1/β1/γ2 | 3.88 | 2020-09-30 | doi.org/10.1038/s41589-020-0646-2 | |
| 6XBK | F | Protein | Frizzled | SMO | Homo sapiens | - | Cholesterol | Gi1/β1/γ2 | 3.24 | 2020-09-30 | doi.org/10.1038/s41589-020-0646-2 | |
| 6XBL | F | Protein | Frizzled | SMO | Homo sapiens | SAG | Cholesterol | Gi1/β1/γ2 | 3.96 | 2020-09-30 | doi.org/10.1038/s41589-020-0646-2 | |
| 6XBM | F | Protein | Frizzled | SMO | Homo sapiens | - | 5LWE | Gi1/β1/γ2 | 3.14 | 2020-09-30 | doi.org/10.1038/s41589-020-0646-2 | |
| 6OT0 | F | Protein | Frizzled | SMO | Homo sapiens | - | 25(S)-Epoxycholesterol | Gi1/β1/γ2 | 3.84 | 2019-06-12 | doi.org/10.1038/s41586-019-1286-0 | |
| 8J9N | F | Protein | Frizzled | FZD1 | Homo sapiens | - | - | chim(Gs-CtGq)/β1/γ2 | 3.5 | 2024-01-17 | doi.org/10.1038/s41421-023-00627-y | |
| 8JHI | F | Protein | Frizzled | FZD3 | Homo sapiens | - | - | chim(NtGsXLas-Gs)/β1/γ2 | 3.2 | 2024-01-17 | doi.org/10.1038/s41421-023-00627-y | |
| 8JHB | F | Protein | Frizzled | FZD6 | Homo sapiens | - | - | chim(NtGsXLas-Gs)/β1/γ2 | 3.3 | 2024-01-17 | doi.org/10.1038/s41421-023-00627-y | |
| 8YY8 | F | Protein | Frizzled | FZD7 | Homo sapiens | - | - | Gs/β1/γ2 | 3.22 | 2024-04-24 | doi.org/10.1038/s41422-021-00525-6 | |
| 9EW2 | F | Protein | Frizzled | FZD7 | Homo sapiens | - | - | Gs/β1/γ2 | 3.2 | 2024-10-02 | doi.org/10.1038/s41467-024-51664-4 | |
| 7EB2 | C | Aminoacid | GABAB | GABAB2; GABAB1 | Homo sapiens | Baclofen | rac-BHFF | Gi1/β1/γ2 | 3.5 | 2021-05-05 | doi.org/10.1038/s41586-021-03507-1 | |
| 7WQ3 | A | Peptide | Galanin | GAL1 | Homo sapiens | Galanin | - | Gi1/β1/γ2 | 2.7 | 2022-04-20 | doi.org/10.1038/s41467-022-29072-3 | |
| 7XJJ | A | Peptide | Galanin | GAL1 | Homo sapiens | Galanin | - | Go/β1/γ2 | 3.3 | 2023-05-03 | doi.org/10.1073/pnas.2121465119 | |
| 7WQ4 | A | Peptide | Galanin | GAL2 | Homo sapiens | Galanin | - | chim(NtGi1-Gs-CtGq)/β1/γ2 | 2.6 | 2022-04-20 | doi.org/10.1038/s41467-022-29072-3 | |
| 7XJK | A | Peptide | Galanin | GAL2 | Homo sapiens | Galanin | - | chim(NtGi2L-Gs-CtGq)/β1/γ2 | 3.3 | 2022-06-29 | doi.org/10.1073/pnas.2121465119 | |
| 7XJL | A | Peptide | Galanin | GAL2 | Homo sapiens | Spexin | - | chim(NtGi2L-Gs-CtGq)/β1/γ2 | 3.5 | 2022-06-29 | doi.org/10.1073/pnas.2121465119 | |
| 7XBD | A | Peptide | Galanin | GAL2 | Homo sapiens | Galanin | - | chim(NtGi2L-Gs-CtGq)/β1/γ2 | 3.11 | 2022-07-13 | doi.org/10.1371/journal.pbio.3001714 | |
| 7F9Y | A | Peptide | Ghrelin | Ghrelin | Homo sapiens | Ghrelin-28 | - | chim(NtGi1-Gs-CtGq)/β1/γ2 | 2.9 | 2021-08-18 | doi.org/10.1038/s41467-021-25364-2 | |
| 7F9Z | A | Peptide | Ghrelin | Ghrelin | Homo sapiens | GHRP-6 | - | chim(NtGi1-Gs-CtGq)/β1/γ2 | 3.2 | 2021-08-18 | doi.org/10.1038/s41467-021-25364-2 | |
| 7NA7 | A | Peptide | Ghrelin | Ghrelin | Homo sapiens | Ghrelin-27 | - | Gi1/β1/γ2 | 2.7 | 2021-12-15 | doi.org/10.1038/s41467-021-26735-5 | |
| 7NA8 | A | Peptide | Ghrelin | Ghrelin | Homo sapiens | PubChem 178024 | - | Gi1/β1/γ2 | 2.7 | 2021-12-15 | doi.org/10.1038/s41467-021-26735-5 | |
| 7W2Z | A | Peptide | Ghrelin | Ghrelin | Homo sapiens | Ghrelin | - | Go/β1/γ2 | 2.8 | 2022-01-19 | doi.org/10.1038/s41467-022-27975-9 | |
| 8JSR | A | Peptide | Ghrelin | Ghrelin | Homo sapiens | Anamorelin | - | chim(NtGi1-Gs-CtGq)/β1/γ2 | 2.9 | 2025-01-22 | doi.org/10.1038/s41594-024-01481-6 | |
| 9UY3 | A | Peptide | Ghrelin | Ghrelin | Homo sapiens | Anamorelin | - | chim(NtGi1-Gs-CtGq)/β1/γ2 | 2.52 | 2025-07-02 | doi.org/10.1038/s41401-025-01606-7 | |
| 9V2N | A | Peptide | Ghrelin | Ghrelin | Homo sapiens | Macimorelin | - | chim(NtGi1-Gs-CtGq)/β1/γ2 | 2.63 | 2025-07-02 | doi.org/10.1038/s41401-025-01606-7 | |
| 6ORV | B1 | Peptide | Glucagon | GLP-1 | Homo sapiens | - | TT-OAD2 | Gs/β1/γ2 | 3 | 2020-01-08 | doi.org/10.1038/s41586-019-1902-z | |
| 7E14 | B1 | Peptide | Glucagon | GLP-1 | Homo sapiens | Orforglipron | PubChem 156022738 | Gs/β1/γ2 | 2.9 | 2021-07-07 | doi.org/10.1038/s41467-021-24058-z | |
| 7DUQ | B1 | Peptide | Glucagon | GLP-1 | Homo sapiens | GLP-1 | PubChem 156022738 | Gs/β1/γ2 | 2.5 | 2021-07-14 | doi.org/10.1038/s41467-021-24058-z | |
| 7DUR | B1 | Peptide | Glucagon | GLP-1 | Homo sapiens | - | PubChem 156022738 | Gs/β1/γ2 | 3.3 | 2021-08-11 | doi.org/10.1038/s41467-021-24058-z | |
| 7EVM | B1 | Peptide | Glucagon | GLP-1 | Homo sapiens | - | PubChem 156022738 | Gs/β1/γ2 | 2.5 | 2021-08-11 | doi.org/10.1038/s41467-021-24058-z | |
| 8WG8 | B1 | Peptide | Glucagon | Glucagon | Homo sapiens | - | Peptide | chim(NtGi1-Gs)/β1/γ2 | 2.71 | 2024-03-06 | doi.org/10.1038/s41421-024-00649-0 | |
| 7RBT | B1 | Peptide | Glucagon | GIP | Homo sapiens | Tirzepatide | LSN3556672 | chim(NtGi1-Gs)/β1/γ2 | 3.08 | 2022-04-13 | doi.org/10.1073/pnas.2116506119 | |
| 9IVM | B1 | Peptide | Glucagon | GLP-1 | Homo sapiens | GLP-1 (Truncated) | LSN3318839 | chim(NtGi1-Gs)/β2/γ2 | 3.22 | 2024-11-13 | doi.org/10.1016/j.apsb.2024.09.002 | |
| 6VCB | B1 | Peptide | Glucagon | GLP-1 | Homo sapiens | GLP-1 | LSN3160440 | Gs/β1/γ2 | 3.3 | 2020-07-22 | doi.org/10.1038/s41589-020-0589-7 | |
| 7CZ5 | B1 | Peptide | Glucagon | GHRH | Homo sapiens | Somatoliberin | - | Gs/β1/γ2 | 2.6 | 2020-11-18 | doi.org/10.1038/s41467-020-18945-0 | |
| 7V9M | B1 | Peptide | Glucagon | GHRH (SV1) | Homo sapiens | Somatoliberin | - | Gs/β1/γ2 | 3.29 | 2021-10-20 | doi.org/10.1073/pnas.2106606118 | |
| 7V9L | B1 | Peptide | Glucagon | GHRH (SV1) | Homo sapiens | - | - | chim(NtGi1-Gs)/β1/γ2 | 2.6 | 2022-04-06 | doi.org/10.1073/pnas.2106606118 | |
| 8WA3 | B1 | Peptide | Glucagon | GIP | Homo sapiens | - | - | Gs/β1/γ2 | 2.86 | 2024-03-06 | doi.org/10.1038/s41421-024-00649-0 | |
| 7FIN | B1 | Peptide | Glucagon | GIP | Homo sapiens | Peptide-20; GGL | - | Gs/β1/γ2 | 3.1 | 2022-02-23 | doi.org/10.1038/s41467-022-28683-0 | |
| 7FIY | B1 | Peptide | Glucagon | GIP | Homo sapiens | Tirzepatide | - | Gs/β1/γ2 | 3.4 | 2022-03-02 | doi.org/10.1038/s41467-022-28683-0 | |
| 7VAB | B1 | Peptide | Glucagon | GIP | Homo sapiens | Non-Acylated Tirzepatide | - | chim(NtGi1-Gs)/β1/γ2 | 3.2 | 2022-03-02 | doi.org/10.1038/s41467-022-28683-0 | |
| 7RA3 | B1 | Peptide | Glucagon | GIP | Homo sapiens | GIP | - | chim(NtGi1-Gs)/β1/γ2 | 3.24 | 2022-04-13 | doi.org/10.1073/pnas.2116506119 | |
| 8ITL | B1 | Peptide | Glucagon | GIP | Homo sapiens | - | - | Gs/β1/γ2 | 3.23 | 2023-10-18 | doi.org/10.1073/pnas.2306145120 | |
| 8ITM | B1 | Peptide | Glucagon | GIP | Homo sapiens | - | - | Gs/β1/γ2 | 3.13 | 2023-10-18 | doi.org/10.1073/pnas.2306145120 | |
| 7DTY | B1 | Peptide | Glucagon | GIP | Homo sapiens | GIP | - | Gs/β1/γ2 | 2.98 | 2021-08-04 | doi.org/10.7554/eLife.68719 | |
| 8YW4 | B1 | Peptide | Glucagon | GIP | Homo sapiens | Retatrutide | - | chim(NtGi1-Gs)/β1/γ2 | 3.26 | 2024-09-18 | doi.org/10.1038/s41421-024-00700-0 | |
| 9IVG | B1 | Peptide | Glucagon | GLP-1 | Homo sapiens | GLP-1 (Truncated) | - | chim(NtGi1-Gs)/β1/γ2 | 3 | 2024-11-27 | doi.org/10.1016/j.apsb.2024.09.002 | |
| 7RTB | B1 | Peptide | Glucagon | GLP-1 | Homo sapiens | Peptide-19 | - | Gs/β1/γ2 | 2.14 | 2021-10-06 | doi.org/10.1016/j.bbrc.2021.09.016 | |
| 7KI0 | B1 | Peptide | Glucagon | GLP-1 | Homo sapiens | Semaglutide | - | Gs/β1/γ2 | 2.5 | 2021-08-04 | doi.org/10.1016/j.celrep.2021.109374 | |
| 7KI1 | B1 | Peptide | Glucagon | GLP-1 | Homo sapiens | Taspoglutide | - | Gs/β1/γ2 | 2.5 | 2021-08-04 | doi.org/10.1016/j.celrep.2021.109374 | |
| 6X18 | B1 | Peptide | Glucagon | GLP-1 | Homo sapiens | GLP-1 | - | Gs/β1/γ2 | 2.1 | 2020-09-09 | doi.org/10.1016/j.molcel.2020.09.020 | |
| 6X19 | B1 | Peptide | Glucagon | GLP-1 | Homo sapiens | CHU-128 | - | Gs/β1/γ2 | 2.1 | 2020-09-09 | doi.org/10.1016/j.molcel.2020.09.020 | |
| 6X1A | B1 | Peptide | Glucagon | GLP-1 | Homo sapiens | Danuglipron | - | Gs/β1/γ2 | 2.5 | 2020-09-09 | doi.org/10.1016/j.molcel.2020.09.020 | |
| 7LCI | B1 | Peptide | Glucagon | GLP-1 | Homo sapiens | Danuglipron | - | Gs/β1/γ2 | 2.9 | 2021-01-20 | doi.org/10.1016/j.str.2021.04.008 | |
| 9J1P | B1 | Peptide | Glucagon | GLP-1 | Homo sapiens | g1:Ox | - | chim(NtGi1-Gs)/β1/γ2 | 2.99 | 2025-02-26 | doi.org/10.1021/jacs.4c12808 | |
| 5VAI | B1 | Peptide | Glucagon | GLP-1 | Oryctolagus cuniculus | GLP-1 | - | Gs/β1/γ2 | 4.1 | 2017-05-24 | doi.org/10.1038/nature22394 | |
| 6B3J | B1 | Peptide | Glucagon | GLP-1 | Homo sapiens | Exendin-P5 | - | Gs/β1/γ2 | 3.3 | 2018-02-21 | doi.org/10.1038/nature25773 | |
| 8WG7 | B1 | Peptide | Glucagon | GLP-1 | Homo sapiens | - | - | Gs/β1/γ2 | 2.54 | 2024-03-06 | doi.org/10.1038/s41421-024-00649-0 | |
| 7C2E | B1 | Peptide | Glucagon | GLP-1 | Homo sapiens | PubChem 149050799 | - | Gs/β1/γ2 | 4.2 | 2020-08-26 | doi.org/10.1038/s41422-020-0384-8 | |
| 7LLL | B1 | Peptide | Glucagon | GLP-1 | Homo sapiens | Exendin-4 | - | Gs/β1/γ2 | 3.7 | 2022-01-12 | doi.org/10.1038/s41467-021-27760-0 | |
| 7LLY | B1 | Peptide | Glucagon | GLP-1 | Homo sapiens | Oxyntomodulin | - | Gs/β1/γ2 | 3.3 | 2022-01-12 | doi.org/10.1038/s41467-021-27760-0 | |
| 7FIM | B1 | Peptide | Glucagon | GLP-1 | Homo sapiens | Tirzepatide | - | Gs/β1/γ2 | 3.4 | 2022-03-02 | doi.org/10.1038/s41467-022-28683-0 | |
| 7VBI | B1 | Peptide | Glucagon | GLP-1 | Homo sapiens | Non-Acylated Tirzepatide | - | Gs/β1/γ2 | 3 | 2022-03-02 | doi.org/10.1038/s41467-022-28683-0 | |
| 7VBH | B1 | Peptide | Glucagon | GLP-1 | Homo sapiens | Peptide-20 | - | Gs/β1/γ2 | 3 | 2022-04-06 | doi.org/10.1038/s41467-022-28683-0 | |
| 7S1M | B1 | Peptide | Glucagon | GLP-1 | Homo sapiens | Ex4-D-Ala | - | Gs/β1/γ2 | 2.41 | 2022-01-05 | doi.org/10.1038/s41589-021-00945-w | |
| 7S3I | B1 | Peptide | Glucagon | GLP-1 | Homo sapiens | - | - | Gs/β1/γ2 | 2.51 | 2022-01-05 | doi.org/10.1038/s41589-021-00945-w | |
| 6XOX | B1 | Peptide | Glucagon | GLP-1 | Homo sapiens | Orforglipron | - | chim(NtGi1-Gs)/β1/γ2 | 3.1 | 2020-11-18 | doi.org/10.1073/pnas.2014879117 | |
| 7RG9 | B1 | Peptide | Glucagon | GLP-1 | Homo sapiens | - | - | chim(NtGi1-Gs)/β1/γ2 | 3.2 | 2022-04-13 | doi.org/10.1073/pnas.2116506119 | |
| 7RGP | B1 | Peptide | Glucagon | GLP-1 | Homo sapiens | Tirzepatide | - | chim(NtGi1-Gs)/β1/γ2 | 2.9 | 2022-04-13 | doi.org/10.1073/pnas.2116506119 | |
| 7X8R | B1 | Peptide | Glucagon | GLP-1 | Homo sapiens | BOC5 | - | Gs/β1/γ2 | 2.61 | 2022-06-29 | doi.org/10.1073/pnas.2200155119 | |
| 7X8S | B1 | Peptide | Glucagon | GLP-1 | Homo sapiens | WB4-24 | - | Gs/β1/γ2 | 3.09 | 2022-06-29 | doi.org/10.1073/pnas.2200155119 | |
| 8JIP | B1 | Peptide | Glucagon | GLP-1 | Homo sapiens | MEDI0382 | - | chim(NtGi1-Gs)/β1/γ2 | 2.85 | 2023-09-06 | doi.org/10.1073/pnas.2303696120 | |
| 8JIR | B1 | Peptide | Glucagon | GLP-1 | Homo sapiens | SAR425899 | - | chim(NtGi1-Gs)/β1/γ2 | 2.57 | 2023-09-06 | doi.org/10.1073/pnas.2303696120 | |
| 8JIS | B1 | Peptide | Glucagon | GLP-1 | Homo sapiens | Peptide-15 | - | chim(NtGi1-Gs)/β1/γ2 | 2.46 | 2023-11-08 | doi.org/10.1073/pnas.2303696120 | |
| 8YW3 | B1 | Peptide | Glucagon | GLP-1 | Homo sapiens | Retatrutide | - | Gs/β1/γ2 | 2.68 | 2024-09-18 | doi.org/10.1038/s41421-024-00700-0 | |
| 9EBN | B1 | Peptide | Glucagon | GLP-1 | Homo sapiens | - | - | Gs/β1/γ2 | 3.44 | 2025-03-26 | doi.org/10.1073/pnas.2407574122 | |
| 9EBO | B1 | Peptide | Glucagon | GLP-1 | Homo sapiens | GLP-1 (ACPC18) | - | Gs/β1/γ2 | 3.13 | 2025-03-26 | doi.org/10.1073/pnas.2407574122 | |
| 9EBQ | B1 | Peptide | Glucagon | GLP-1 | Homo sapiens | - | - | Gs/β1/γ2 | 3.16 | 2025-03-26 | doi.org/10.1073/pnas.2407574122 | |
| 8YWF | B1 | Peptide | Glucagon | GLP-1 | Homo sapiens | Retatrutide | - | chim(NtGi1-Gs)/β1/γ2 | 2.74 | 2025-04-16 | To be published | |
| 9BYO | B1 | Peptide | Glucagon | GLP-1 | Homo sapiens | Exendin-3 | - | Gs/β1/γ2 | 2.31 | 2025-06-11 | To be published | |
| 9C0K | B1 | Peptide | Glucagon | GLP-1 | Homo sapiens | Exendin-4 | - | Gs/β1/γ2 | 2.72 | 2025-06-11 | To be published | |
| 7D68 | B1 | Peptide | Glucagon | GLP-2 | Homo sapiens | GLP-2 | - | Gs/β1/γ2 | 3 | 2020-12-16 | doi.org/10.1038/s41422-020-00442-0 | |
| 8FU6 | B1 | Peptide | Glucagon | Glucagon | Homo sapiens | Glucagon derivative ZP3780 | - | Gs/β1/γ2 | 2.9 | 2023-04-12 | doi.org/10.1016/j.cell.2023.02.028 | |
| 7V35 | B1 | Peptide | Glucagon | Glucagon | Homo sapiens | Peptide-20 | - | Gs/β1/γ2 | 3.5 | 2022-03-02 | doi.org/10.1038/s41467-022-28683-0 | |
| 8JIT | B1 | Peptide | Glucagon | Glucagon | Homo sapiens | MEDI0382 | - | Gs/β1/γ2 | 2.91 | 2023-09-06 | doi.org/10.1073/pnas.2303696120 | |
| 8JIQ | B1 | Peptide | Glucagon | Glucagon | Homo sapiens | Peptide-15 | - | Gs/β1/γ2 | 3.4 | 2023-09-13 | doi.org/10.1073/pnas.2303696120 | |
| 8JIU | B1 | Peptide | Glucagon | Glucagon | Homo sapiens | SAR425899 | - | Gs/β1/γ2 | 2.76 | 2023-09-13 | doi.org/10.1073/pnas.2303696120 | |
| 6WHC | B1 | Peptide | Glucagon | Glucagon | Homo sapiens | Glu16 analog of GCG | - | Gs/β1/γ2 | 3.4 | 2020-05-27 | doi.org/10.1074/jbc.RA120.013793 | |
| 6LMK | B1 | Peptide | Glucagon | Glucagon | Homo sapiens | Glucagon | - | Gs/β1/γ2 | 3.7 | 2020-04-01 | doi.org/10.1126/science.aaz5346 | |
| 6LML | B1 | Peptide | Glucagon | Glucagon | Homo sapiens | Glucagon | - | Gi1/β1/γ1 | 3.9 | 2020-04-01 | doi.org/10.1126/science.aaz5346 | |
| 6WPW | B1 | Peptide | Glucagon | Glucagon | Homo sapiens | Glucagon derivative ZP3780 | - | Gs/β1/γ2 | 3.1 | 2020-08-12 | doi.org/10.1126/science.aba3373 | |
| 8YW5 | B1 | Peptide | Glucagon | Glucagon | Homo sapiens | Retatrutide | - | Gs/β1/γ2 | 2.84 | 2024-09-18 | doi.org/10.1038/s41421-024-00700-0 | |
| 7D3S | B1 | Peptide | Glucagon | Secretin | Homo sapiens | Secretin | - | Gs/β1/γ2 | 2.9 | 2020-11-04 | doi.org/10.1016/j.bbrc.2020.08.042 | |
| 6WI9 | B1 | Peptide | Glucagon | Secretin | Homo sapiens | Secretin | - | Gs/β1/γ2 | 4.3 | 2020-08-12 | doi.org/10.1038/s41467-020-17791-4 | |
| 6WZG | B1 | Peptide | Glucagon | Secretin | Homo sapiens | Secretin | - | Gs/β1/γ2 | 2.3 | 2020-08-12 | doi.org/10.1038/s41467-020-17791-4 | |
| 7FIH | A | Protein | Glycoprotein Hormone | LH | Homo sapiens | hCG | Org43553 | chim(NtGi1-Gs)/β1/γ2 | 3.2 | 2021-09-29 | doi.org/10.1038/s41586-021-03924-2 | |
| 7XW6 | A | Protein | Glycoprotein Hormone | TSH | Homo sapiens | M22 Fab | ML109 | Gs/β1/γ2 | 2.78 | 2022-08-17 | doi.org/10.1038/s41586-022-05173-3 | |
| 7XW5 | A | Protein | Glycoprotein Hormone | TSH | Homo sapiens | TSH | ML109 | Gs/β1/γ2 | 2.96 | 2022-08-24 | doi.org/10.1038/s41586-022-05173-3 | |
| 7T9N | A | Protein | Glycoprotein Hormone | TSH | Homo sapiens | M22 Fab | DPPC | Gs/β1/γ2 | 2.9 | 2022-08-03 | doi.org/10.1038/s41586-022-05159-1 | |
| 7UTZ | A | Protein | Glycoprotein Hormone | TSH | Homo sapiens | TR1402 | DPPC | Gs/β1/γ2 | 2.4 | 2022-08-03 | doi.org/10.1038/s41586-022-05159-1 | |
| 8I2G | A | Protein | Glycoprotein Hormone | FSH | Homo sapiens | Glycoprotein hormones α chain | Compound 716340 | Gs/β1/γ2 | 2.8 | 2023-03-29 | doi.org/10.1038/s41467-023-36170-3 | |
| 7FIG | A | Protein | Glycoprotein Hormone | LH | Homo sapiens | hCG | - | chim(NtGi1L-Gs)/β1/γ2 | 3.9 | 2021-09-29 | doi.org/10.1038/s41586-021-03924-2 | |
| 7FII | A | Protein | Glycoprotein Hormone | LH | Homo sapiens | hCG | - | chim(NtGi1-Gs)/β1/γ2 | 4.3 | 2021-09-29 | doi.org/10.1038/s41586-021-03924-2 | |
| 7T9I | A | Protein | Glycoprotein Hormone | TSH | Homo sapiens | TSH | - | Gs/β1/γ2 | 2.9 | 2022-08-03 | doi.org/10.1038/s41586-022-05159-1 | |
| 9U4W | A | Peptide | Gonadotrophin Releasing Hormone | GnRH1 | Sus scrofa | Gonadoliberin-1 | - | chim(NtGi1L-Gs-CtGq)/β1/γ2 | 3.18 | 2025-06-11 | doi.org/10.1073/pnas.2500112122 | |
| 9U4Y | A | Peptide | Gonadotrophin Releasing Hormone | GnRH1 | Xenopus laevis | Gonadoliberin-1 | - | chim(NtGi1L-Gs-CtGq)/β1/γ2 | 3.18 | 2025-06-11 | doi.org/10.1073/pnas.2500112122 | |
| 7WCM | A | Lipid | GPR119 | GPR119 | Homo sapiens | MBX-2982 | - | Gs/β1/γ2 | 2.33 | 2022-12-21 | doi.org/10.1038/s41467-022-34696-6 | |
| 7WCN | A | Lipid | GPR119 | GPR119 | Homo sapiens | AR231453 | - | Gs/β1/γ2 | 2.87 | 2022-12-21 | doi.org/10.1038/s41467-022-34696-6 | |
| 7XZ5 | A | Lipid | GPR119 | GPR119 | Homo sapiens | Lysophosphatidylcholine | - | Gs/β1/γ2 | 3.1 | 2022-08-24 | doi.org/10.1038/s41594-022-00816-5 | |
| 7XZ6 | A | Lipid | GPR119 | GPR119 | Homo sapiens | APD668 | - | Gs/β1/γ2 | 2.8 | 2022-08-24 | doi.org/10.1038/s41594-022-00816-5 | |
| 8VHF | A | Lipid | GPR119 | GPR119 | Homo sapiens | MBX-2982 | - | Gs/β1/γ2 | 3.51 | 2024-10-30 | doi.org/10.1016/j.str.2024.10.004 | |
| 8ZR5 | A | Lipid | GPR119 | GPR119 | Homo sapiens | Firuglipel | - | Gs/β1/γ2 | 3.31 | 2024-06-19 | To be published | |
| 8ZRK | A | Lipid | GPR119 | GPR119 | Homo sapiens | GSK-1292263 | - | Gs/β1/γ2 | 2.82 | 2024-06-19 | To be published | |
| 8ZX4 | A | Lipid | GPR55 | GPR55 | Homo sapiens | Lysophosphatidylinositol | - | chim(NtGi1-G13)/β1/γ2 | 3.03 | 2024-11-13 | doi.org/10.1038/s41422-024-01044-w | |
| 8ZX5 | A | Lipid | GPR55 | GPR55 | Homo sapiens | AM251 | - | chim(NtGi1-G13)/β1/γ2 | 2.85 | 2024-11-13 | doi.org/10.1038/s41422-024-01044-w | |
| 8JXT | A | Amine | Histamine | H4 | Homo sapiens | Histamine | PO4 | Gi1/β1/γ2 | 3.07 | 2024-03-20 | doi.org/10.1038/s41467-024-46840-5 | |
| 7DFL | A | Amine | Histamine | H1 | Homo sapiens | Histamine | - | chim(NtGi1L-Gq)/β1/γ2 | 3.3 | 2021-03-31 | doi.org/10.1038/s41467-021-22427-2 | |
| 8YN2 | A | Amine | Histamine | H1 | Homo sapiens | Histamine | - | chim(NtGi1L-Gs-CtGq)/β1/γ2 | 2.66 | 2024-10-09 | doi.org/10.1038/s41467-024-52585-y | |
| 9LRD | A | Amine | Histamine | H1 | Homo sapiens | Histamine | - | Gi1/β1/γ2 | 3.23 | 2025-06-11 | To be published | |
| 9LRB | A | Amine | Histamine | H1 | Homo sapiens | Histamine | - | Gs/β1/γ2 | 2.77 | 2025-06-11 | To be published | |
| 8YUT | A | Amine | Histamine | H2 | Homo sapiens | Amthamine | - | Gs/β1/γ2 | 2.7 | 2024-06-05 | doi.org/10.1002/advs.202310120 | |
| 8POK | A | Amine | Histamine | H2 | Homo sapiens | Histamine | - | Gs/β1/γ2 | 3.4 | 2024-03-06 | doi.org/10.1038/s41467-024-46096-z | |
| 8YN3 | A | Amine | Histamine | H2 | Homo sapiens | Histamine | - | Gs/β1/γ2 | 2.56 | 2024-10-09 | doi.org/10.1038/s41467-024-52585-y | |
| 8YN4 | A | Amine | Histamine | H2 | Homo sapiens | Histamine | - | chim(NtGi1L-Gs-CtGq)/β1/γ2 | 2.97 | 2024-10-09 | doi.org/10.1038/s41467-024-52585-y | |
| 8YUV | A | Amine | Histamine | H3 | Homo sapiens | Immepip | - | Gi1/β1/γ2 | 3 | 2024-06-05 | doi.org/10.1002/advs.202310120 | |
| 8YN7 | A | Amine | Histamine | H3 | Homo sapiens | Immethridine | - | Go/β1/γ2 | 2.77 | 2024-10-16 | doi.org/10.2210/pdb8YN7/pdb | |
| 8YN8 | A | Amine | Histamine | H3 | Homo sapiens | Proxyfan | - | Go/β1/γ2 | 2.77 | 2024-10-16 | doi.org/10.2210/pdb8YN7/pdb | |
| 8YUU | A | Amine | Histamine | H3 | Homo sapiens | Histamine | - | Gi1/β1/γ1 | 2.7 | 2024-06-05 | doi.org/10.1002/advs.202310120 | |
| 8YN5 | A | Amine | Histamine | H3 | Homo sapiens | Histamine | - | Gi1/β1/γ2 | 2.7 | 2024-10-09 | doi.org/10.1038/s41467-024-52585-y | |
| 8YN6 | A | Amine | Histamine | H3 | Homo sapiens | Imetit | - | Gi1/β1/γ2 | 2.77 | 2024-10-09 | doi.org/10.1038/s41467-024-52585-y | |
| 7YFC | A | Amine | Histamine | H4 | Homo sapiens | Histamine | - | chim(NtGi1-Gs-CtGq)/β1/γ2 | 3 | 2023-10-25 | doi.org/10.1038/s41467-023-42260-z | |
| 7YFD | A | Amine | Histamine | H4 | Homo sapiens | Imetit | - | chim(NtGi1-Gs-CtGq)/β1/γ2 | 3.1 | 2023-10-25 | doi.org/10.1038/s41467-023-42260-z | |
| 8JXV | A | Amine | Histamine | H4 | Homo sapiens | Clozapine | - | Gi1/β1/γ2 | 3.21 | 2024-03-20 | doi.org/10.1038/s41467-024-46840-5 | |
| 8JXW | A | Amine | Histamine | H4 | Homo sapiens | VUF6884 | - | Gi1/β1/γ2 | 3.01 | 2024-03-20 | doi.org/10.1038/s41467-024-46840-5 | |
| 8JXX | A | Amine | Histamine | H4 | Homo sapiens | Clobenpropit | - | Gi1/β1/γ2 | 3.06 | 2024-03-20 | doi.org/10.1038/s41467-024-46840-5 | |
| 8YNA | A | Amine | Histamine | H4 | Homo sapiens | Immepip | - | Gi1/β1/γ2 | 2.63 | 2024-10-16 | doi.org/10.2210/pdb8YN7/pdb | |
| 8YN9 | A | Amine | Histamine | H4 | Homo sapiens | Histamine | - | Gi1/β1/γ2 | 2.3 | 2024-10-09 | doi.org/10.1038/s41467-024-52585-y | |
| 8HN8 | A | Amine | Histamine | H4 | Homo sapiens | Histamine | - | Gi1/β1/γ2 | 3 | 2023-12-20 | To be published | |
| 8HOC | A | Amine | Histamine | H4 | Homo sapiens | Imetit | - | Gi1/β1/γ2 | 3 | 2023-12-20 | To be published | |
| 9LRE | A | Amine | Histamine | H4 | Homo sapiens | Histamine | - | Gi1/β1/γ2 | 2.84 | 2025-06-11 | To be published | |
| 8JHY | A | Alicarboxylic acid | Hydroxycarboxylic Acid | HCA2 | Homo sapiens | - | Compound 9n | Gi1/β1/γ2 | 2.87 | 2023-09-06 | doi.org/10.1016/j.molcel.2023.07.030 | |
| 8JII | A | Alicarboxylic acid | Hydroxycarboxylic Acid | HCA2 | Homo sapiens | Niacin | Compound 9n | Gi1/β1/γ2 | 3.17 | 2023-09-06 | doi.org/10.1016/j.molcel.2023.07.030 | |
| 8J6P | A | Alicarboxylic acid | Hydroxycarboxylic Acid | HCA2 | Homo sapiens | Niacin | Compound 9n | Gi1/β1/γ2 | 2.55 | 2023-12-06 | doi.org/10.1038/s41467-023-43537-z | |
| 8J6Q | A | Alicarboxylic acid | Hydroxycarboxylic Acid | HCA2 | Homo sapiens | β-Hydroxybutyrate | Compound 9n | Gi1/β1/γ2 | 2.6 | 2023-12-06 | doi.org/10.1038/s41467-023-43537-z | |
| 9IZD | A | Alicarboxylic acid | Hydroxycarboxylic acid | HCA1 | Homo sapiens | CHBA | - | Gi1/β1/γ2 | 3.16 | 2025-04-02 | To be published | |
| 9J8Z | A | Alicarboxylic acid | Hydroxycarboxylic acid | HCA1 | Homo sapiens | - | - | Gi1/β1/γ2 | 3.36 | 2025-04-02 | To be published | |
| 8UTD | A | Alicarboxylic acid | Hydroxycarboxylic Acid | HCA2 | Homo sapiens | MK1903 | - | Gi1/β1/γ2 | 3.24 | 2025-02-26 | doi.org/10.1016/j.cell.2024.11.001 | |
| 8UUJ | A | Alicarboxylic acid | Hydroxycarboxylic Acid | HCA2 | Mus musculus | FCH-2296413 | - | Gi1/β1/γ2 | 2.62 | 2025-02-26 | doi.org/10.1016/j.cell.2024.11.001 | |
| 8J6J | A | Alicarboxylic acid | Hydroxycarboxylic Acid | HCA2 | Homo sapiens | GSK256073 | - | Gi1/β1/γ2 | 2.8 | 2024-01-10 | doi.org/10.1016/j.celrep.2023.113406 | |
| 8J6I | A | Alicarboxylic acid | Hydroxycarboxylic Acid | HCA2 | Homo sapiens | MK6892 | - | Gi1/β1/γ2 | 2.92 | 2024-04-03 | doi.org/10.1016/j.celrep.2023.113406 | |
| 8J6L | A | Alicarboxylic acid | Hydroxycarboxylic Acid | HCA2 | Homo sapiens | Niacin | - | Gi1/β1/γ2 | 3.05 | 2024-04-03 | doi.org/10.1016/j.celrep.2023.113406 | |
| 8JIL | A | Alicarboxylic acid | Hydroxycarboxylic Acid | HCA2 | Homo sapiens | Niacin | - | Gi1/β1/γ2 | 3.5 | 2023-09-06 | doi.org/10.1016/j.molcel.2023.07.030 | |
| 8JIM | A | Alicarboxylic acid | Hydroxycarboxylic Acid | HCA2 | Homo sapiens | MMF | - | Gi1/β1/γ2 | 2.98 | 2023-09-06 | doi.org/10.1016/j.molcel.2023.07.030 | |
| 8JZ7 | A | Alicarboxylic acid | Hydroxycarboxylic Acid | HCA2 | Homo sapiens | MK6892 | - | Gi1/β1/γ2 | 2.6 | 2023-10-04 | doi.org/10.1038/s41392-023-01625-y | |
| 8IJ3 | A | Alicarboxylic acid | Hydroxycarboxylic Acid | HCA2 | Homo sapiens | - | - | Gi1/β1/γ2 | 3.28 | 2024-01-03 | doi.org/10.1038/s41421-023-00610-7 | |
| 8IJA | A | Alicarboxylic acid | Hydroxycarboxylic Acid | HCA2 | Homo sapiens | Niacin | - | Gi1/β1/γ2 | 2.69 | 2024-01-03 | doi.org/10.1038/s41421-023-00610-7 | |
| 8IJB | A | Alicarboxylic acid | Hydroxycarboxylic Acid | HCA2 | Homo sapiens | Acipimox | - | Gi1/β1/γ2 | 3.23 | 2024-01-03 | doi.org/10.1038/s41421-023-00610-7 | |
| 8IJD | A | Alicarboxylic acid | Hydroxycarboxylic Acid | HCA2 | Homo sapiens | MK6892 | - | Gi1/β1/γ2 | 3.25 | 2024-01-03 | doi.org/10.1038/s41421-023-00610-7 | |
| 7XK2 | A | Alicarboxylic acid | Hydroxycarboxylic Acid | HCA2 | Homo sapiens | MK6892 | - | Gi1/β1/γ2 | 3.1 | 2023-02-22 | doi.org/10.1038/s41467-023-37177-6 | |
| 8IHF | A | Alicarboxylic acid | Hydroxycarboxylic Acid | HCA2 | Homo sapiens | MK6892 | - | Gi1/β1/γ2 | 2.97 | 2023-08-30 | doi.org/10.1038/s41467-023-41650-7 | |
| 8IHH | A | Alicarboxylic acid | Hydroxycarboxylic Acid | HCA2 | Homo sapiens | LUF6283 | - | Gi1/β1/γ2 | 3.06 | 2023-08-30 | doi.org/10.1038/s41467-023-41650-7 | |
| 8IHI | A | Alicarboxylic acid | Hydroxycarboxylic Acid | HCA2 | Homo sapiens | Acifran | - | Gi1/β1/γ2 | 3.11 | 2023-08-30 | doi.org/10.1038/s41467-023-41650-7 | |
| 8IHB | A | Alicarboxylic acid | Hydroxycarboxylic Acid | HCA2 | Homo sapiens | GSK256073 | - | Gi1/β1/γ2 | 2.85 | 2023-09-13 | doi.org/10.1038/s41467-023-41650-7 | |
| 8I7V | A | Alicarboxylic acid | Hydroxycarboxylic Acid | HCA2 | Homo sapiens | Acipimox | - | Gi1/β1/γ2 | 2.77 | 2024-02-07 | doi.org/10.1038/s41467-023-42764-8 | |
| 8I7W | A | Alicarboxylic acid | Hydroxycarboxylic Acid | HCA2 | Homo sapiens | GSK256073 | - | Gi1/β1/γ2 | 3.39 | 2024-02-07 | doi.org/10.1038/s41467-023-42764-8 | |
| 8J6R | A | Alicarboxylic acid | Hydroxycarboxylic Acid | HCA2 | Homo sapiens | MK6892 | - | Gi1/β1/γ2 | 2.76 | 2023-12-06 | doi.org/10.1038/s41467-023-43537-z | |
| 8IY9 | A | Alicarboxylic acid | Hydroxycarboxylic Acid | HCA2 | Homo sapiens | Niacin | - | Go/β1/γ2 | 3.37 | 2024-03-06 | doi.org/10.1038/s41467-024-46239-2 | |
| 8IYH | A | Alicarboxylic acid | Hydroxycarboxylic Acid | HCA2 | Homo sapiens | MK6892 | - | Go/β1/γ2 | 3.3 | 2024-03-06 | doi.org/10.1038/s41467-024-46239-2 | |
| 8IYW | A | Alicarboxylic acid | Hydroxycarboxylic Acid | HCA2 | Homo sapiens | GSK256073 | - | Go/β1/γ2 | 3.45 | 2024-03-06 | doi.org/10.1038/s41467-024-46239-2 | |
| 8JER | A | Alicarboxylic acid | Hydroxycarboxylic Acid | HCA2 | Homo sapiens | Acipimox | - | Go/β1/γ2 | 3.45 | 2024-03-06 | doi.org/10.1038/s41467-024-46239-2 | |
| 8JHN | A | Alicarboxylic acid | Hydroxycarboxylic Acid | HCA2 | Homo sapiens | MMF | - | Go/β1/γ2 | 3.75 | 2024-03-06 | doi.org/10.1038/s41467-024-46239-2 | |
| 9IQT | A | Alicarboxylic acid | Hydroxycarboxylic acid | HCA2 | Homo sapiens | Niacin | - | Gi1/β1/γ2 | 2.9 | 2024-10-02 | doi.org/10.1016/j.jmb.2024.168795 | |
| 8H2G | A | Alicarboxylic acid | Hydroxycarboxylic Acid | HCA2 | Homo sapiens | Niacin | - | Gi1/β1/γ2 | 3.01 | 2023-10-11 | doi.org/10.1038/s41467-023-42764-8 | |
| 9IZA | A | Alicarboxylic acid | Hydroxycarboxylic acid | HCA2 | Homo sapiens | SCH900271 | - | Gi1/β1/γ2 | 3.06 | 2025-04-02 | To be published | |
| 9IZC | A | Alicarboxylic acid | Hydroxycarboxylic acid | HCA2 | Homo sapiens | MK1903 | - | Gi1/β1/γ2 | 2.68 | 2025-04-02 | To be published | |
| 8IHJ | A | Alicarboxylic acid | Hydroxycarboxylic Acid | HCA3 | Homo sapiens | Acifran | - | Gi1/β1/γ2 | 3.07 | 2023-08-30 | doi.org/10.1038/s41467-023-41650-7 | |
| 8JEF | A | Alicarboxylic acid | Hydroxycarboxylic Acid | HCA3 | Homo sapiens | (3S)-3-hydroxyoctanoic acid | - | Gi1/β1/γ2 | 2.96 | 2024-12-18 | doi.org/10.1016/j.celrep.2024.114895 | |
| 8JEI | A | Alicarboxylic acid | Hydroxycarboxylic Acid | HCAR3 | Homo sapiens | 3-nitro-4-(propylamino)benzoic acid | - | Gi1/β1/γ2 | 2.73 | 2024-11-20 | doi.org/10.2210/pdb8JEI/pdb | |
| 8ZJD | A | Peptide | Kisspeptin | Kiss1 | Homo sapiens | Kisspeptin-10 | - | chim(NtGi1-Gq)/β1/γ1 | 3.06 | 2024-07-03 | doi.org/10.1016/j.celrep.2024.114389 | |
| 8ZJE | A | Peptide | Kisspeptin | Kiss1 | Homo sapiens | TAK-448 | - | chim(NtGi1-Gq)/β1/γ1 | 3.07 | 2024-07-03 | doi.org/10.1016/j.celrep.2024.114389 | |
| 8XGO | A | Peptide | Kisspeptin | Kiss1 | Homo sapiens | TAK448 | - | chim(NtGi1-Gq)/β1/γ2 | 2.68 | 2024-10-30 | doi.org/10.1126/sciadv.adn7771 | |
| 8XGS | A | Peptide | Kisspeptin | Kiss1 | Homo sapiens | Metastin | - | chim(NtGi1-Gq)/β1/γ2 | 2.95 | 2024-10-30 | doi.org/10.1126/sciadv.adn7771 | |
| 8XGU | A | Peptide | Kisspeptin | Kiss1 | Homo sapiens | TAK448 | - | Gi1/β1/γ2 | 3 | 2024-10-30 | doi.org/10.1126/sciadv.adn7771 | |
| 7VKT | A | Lipid | Leukotriene | BLT1 | Homo sapiens | LTB4 | - | Gi1/β1/γ2 | 2.9 | 2022-03-09 | doi.org/10.1038/s41467-022-28820-9 | |
| 9JH5 | A | Lipid | Leukotriene | CysLT2 | Homo sapiens | C16:0 Ceramide | - | chim(NtGi1-Gs-CtGq)/β1/γ2 | 2.76 | 2025-04-23 | doi.org/10.1038/s41586-025-08792-8 | |
| 9JH6 | A | Lipid | Leukotriene | CysLT2 | Homo sapiens | C20:0 Ceramide | - | chim(NtGi1-Gs-CtGq)/β1/γ2 | 2.89 | 2025-04-23 | doi.org/10.1038/s41586-025-08792-8 | |
| 9IXX | A | Lipid | Leukotriene | CysLT2 | Homo sapiens | LTD4 | - | chim(NtGi1-Gs-CtGq)/β1/γ2 | 3.15 | 2025-04-02 | doi.org/10.1073/pnas.2417148122 | |
| 8G94 | A | Lipid | Lysophospholipid | S1P1 | Homo sapiens | - | CD69 | Gi1/β1/γ2 | 3.15 | 2023-04-19 | doi.org/10.7554/eLife.88204 | |
| 9IZF | A | Lipid | Lysophospholipid | LPA1 | Homo sapiens | NKP | - | Gi1/β1/γ2 | 3.14 | 2025-01-01 | doi.org/10.1016/j.jsb.2024.108164 | |
| 9IZG | A | Lipid | Lysophospholipid | LPA1 | Homo sapiens | NKP | - | chim(NtGi1-Gs-CtGq)/β1/γ2 | 3.04 | 2025-01-01 | doi.org/10.1016/j.jsb.2024.108164 | |
| 7TD0 | A | Lipid | Lysophospholipid | LPA1 | Homo sapiens | LPA | - | Gi1/β1/γ2 | 2.83 | 2022-02-09 | doi.org/10.1038/s41467-022-28417-2 | |
| 7TD1 | A | Lipid | Lysophospholipid | LPA1 | Homo sapiens | LPA | - | Gi1/β1/γ2 | 3.08 | 2022-02-09 | doi.org/10.1038/s41467-022-28417-2 | |
| 7TD2 | A | Lipid | Lysophospholipid | LPA1 | Homo sapiens | LPA | - | Gi1/β1/γ2 | 3.11 | 2022-02-09 | doi.org/10.1038/s41467-022-28417-2 | |
| 7YU3 | A | Lipid | Lysophospholipid | LPA1 | Homo sapiens | ONO-0740556 | - | Gi1/β1/γ2 | 3.5 | 2022-10-05 | doi.org/10.1038/s41467-022-33121-2 | |
| 7YU5 | A | Lipid | Lysophospholipid | LPA1 | Homo sapiens | ONO-0740556 | - | Gi1/β1/γ2 | 3.7 | 2022-10-05 | doi.org/10.1038/s41467-022-33121-2 | |
| 7YU6 | A | Lipid | Lysophospholipid | LPA1 | Homo sapiens | ONO-0740556 | - | Gi1/β1/γ2 | 3.9 | 2022-10-05 | doi.org/10.1038/s41467-022-33121-2 | |
| 7YU7 | A | Lipid | Lysophospholipid | LPA1 | Homo sapiens | ONO-0740556 | - | Gi1/β1/γ2 | 4.5 | 2022-10-05 | doi.org/10.1038/s41467-022-33121-2 | |
| 7YU8 | A | Lipid | Lysophospholipid | LPA1 | Homo sapiens | ONO-0740556 | - | Gi1/β1/γ2 | 5.6 | 2022-10-05 | doi.org/10.1038/s41467-022-33121-2 | |
| 9J5V | A | Lipid | Lysophospholipid | LPA1 | Homo sapiens | CpY | - | Gi1/β1/γ2 | 2.86 | 2024-11-27 | doi.org/10.1038/s42003-024-07152-y | |
| 9IZH | A | Lipid | Lysophospholipid | LPA1 | Homo sapiens | LPA | - | chim(NtGi2-G13)/β1/γ2 | 3.04 | 2025-01-01 | doi.org/10.1016/j.jsb.2024.108164 | |
| 9ITB | A | Lipid | Lysophospholipid | LPA6 | Homo sapiens | LPA | - | chim(NtGi1-Gs-CtGq)/β1/γ2 | 2.89 | 2025-01-15 | doi.org/10.1073/pnas.2415426122 | |
| 9ITE | A | Lipid | Lysophospholipid | LPA6 | Homo sapiens | LPA | - | chim(NtGi2-G13)/β1/γ2 | 3.06 | 2025-01-15 | doi.org/10.1073/pnas.2415426122 | |
| 7EVY | A | Lipid | Lysophospholipid | S1P1 | Homo sapiens | Siponimod | - | Gi1/β1/γ2 | 2.98 | 2021-09-29 | doi.org/10.1038/s41422-021-00566-x | |
| 7EVZ | A | Lipid | Lysophospholipid | S1P1 | Homo sapiens | Cenerimod | - | Gi1/β1/γ2 | 3.07 | 2021-09-29 | doi.org/10.1038/s41422-021-00566-x | |
| 7EW0 | A | Lipid | Lysophospholipid | S1P1 | Homo sapiens | Ozanimod | - | Gi1/β1/γ2 | 3.42 | 2021-09-29 | doi.org/10.1038/s41422-021-00566-x | |
| 7EW7 | A | Lipid | Lysophospholipid | S1P1 | Homo sapiens | SEW2871 | - | Gi1/β1/γ2 | 3.27 | 2021-09-29 | doi.org/10.1038/s41422-021-00566-x | |
| 7TD3 | A | Lipid | Lysophospholipid | S1P1 | Homo sapiens | S1P | - | Gi1/β1/γ2 | 3 | 2022-02-09 | doi.org/10.1038/s41467-022-28417-2 | |
| 7TD4 | A | Lipid | Lysophospholipid | S1P1 | Homo sapiens | Siponimod | - | Gi1/β1/γ2 | 2.6 | 2022-02-09 | doi.org/10.1038/s41467-022-28417-2 | |
| 7EO2 | A | Lipid | Lysophospholipid | S1P1 | Homo sapiens | FTY720-P | - | Gi1/β1/γ2 | 2.89 | 2022-01-05 | doi.org/10.1038/s41589-021-00930-3 | |
| 7EO4 | A | Lipid | Lysophospholipid | S1P1 | Homo sapiens | BAF312 | - | Gi1/β1/γ2 | 2.86 | 2022-01-05 | doi.org/10.1038/s41589-021-00930-3 | |
| 7WF7 | A | Lipid | Lysophospholipid | S1P1 | Homo sapiens | S1P | - | Gi1/β1/γ2 | 3.4 | 2022-01-05 | doi.org/10.1038/s41589-021-00930-3 | |
| 7VIE | A | Lipid | Lysophospholipid | S1P1 | Homo sapiens | S1P | - | Gi1/β1/γ2 | 2.86 | 2022-09-28 | doi.org/10.1073/pnas.2117716119 | |
| 7VIF | A | Lipid | Lysophospholipid | S1P1 | Homo sapiens | S-FTY720-P | - | Gi1/β1/γ2 | 2.83 | 2022-09-28 | doi.org/10.1073/pnas.2117716119 | |
| 7VIG | A | Lipid | Lysophospholipid | S1P1 | Homo sapiens | CBP-307 | - | Gi1/β1/γ2 | 2.89 | 2022-09-28 | doi.org/10.1073/pnas.2117716119 | |
| 7VIH | A | Lipid | Lysophospholipid | S1P1 | Homo sapiens | CBP-307 | - | Gi1/β1/γ2 | 2.98 | 2022-09-28 | doi.org/10.1073/pnas.2117716119 | |
| 8YIC | A | Lipid | Lysophospholipid | S1P1 | Homo sapiens | SAR247799 | - | Gi1/β1/γ2 | 3.47 | 2024-12-11 | To be published | |
| 7T6B | A | Lipid | Lysophospholipid | S1P2 | Homo sapiens | S1P | - | chim(NtGi1L-G13)/β1/γ2 | 3.19 | 2022-04-06 | doi.org/10.1126/sciadv.abn0067 | |
| 7EW2 | A | Lipid | Lysophospholipid | S1P3 | Homo sapiens | Fingolimod | - | Gi1/β1/γ2 | 3.1 | 2021-09-29 | doi.org/10.1038/s41422-021-00567-w | |
| 7EW3 | A | Lipid | Lysophospholipid | S1P3 | Homo sapiens | S1P | - | Gi1/β1/γ2 | 3.1 | 2021-09-29 | doi.org/10.1038/s41422-021-00567-w | |
| 7EW4 | A | Lipid | Lysophospholipid | S1P3 | Homo sapiens | CYM5541 | - | Gi1/β1/γ2 | 3.2 | 2021-09-29 | doi.org/10.1038/s41422-021-00567-w | |
| 7EW1 | A | Lipid | Lysophospholipid | S1P5 | Homo sapiens | Siponimod | - | Gi1/β1/γ2 | 3.4 | 2021-09-29 | doi.org/10.1038/s41422-021-00566-x | |
| 8WSS | A | Peptide | Melanin Concentrating Hormone | MCH1 | Homo sapiens | Pro-MCH | - | Gi1/β1/γ1 | 3.01 | 2024-06-19 | doi.org/10.1038/s41421-024-00679-8 | |
| 8WWK | A | Peptide | Melanin Concentrating Hormone | MCH1 | Homo sapiens | MCH | - | Gi1/β1/γ2 | 2.61 | 2024-11-13 | doi.org/10.1038/s41421-024-00754-0 | |
| 8WWL | A | Peptide | Melanin Concentrating Hormone | MCH1 | Homo sapiens | MCH | - | Gi1/β1/γ2 | 2.78 | 2024-11-13 | doi.org/10.1038/s41421-024-00754-0 | |
| 8WWM | A | Peptide | Melanin Concentrating Hormone | MCH1 | Homo sapiens | MCH | - | Gi1/β1/γ2 | 2.81 | 2024-11-13 | doi.org/10.1038/s41421-024-00754-0 | |
| 8WWN | A | Peptide | Melanin Concentrating Hormone | MCH1 | Homo sapiens | MCH | - | Gi1/β1/γ2 | 2.65 | 2024-11-13 | doi.org/10.1038/s41421-024-00754-0 | |
| 8WWH | A | Peptide | Melanin Concentrating Hormone | MCH1 | Homo sapiens | - | - | Gi1/β1/γ2 | 2.84 | 2024-11-13 | To be published | |
| 8WWI | A | Peptide | Melanin Concentrating Hormone | MCH1 | Homo sapiens | - | - | Gi1/β1/γ2 | 3.43 | 2024-11-13 | To be published | |
| 8WWJ | A | Peptide | Melanin Concentrating Hormone | MCH1 | Homo sapiens | - | - | Gi1/β1/γ2 | 3.03 | 2024-11-13 | To be published | |
| 8WST | A | Peptide | Melanin Concentrating Hormone | MCH2 | Homo sapiens | Pro-MCH | - | chim(NtGi1L-Gs-CtGq)/β1/γ2 | 2.4 | 2024-06-19 | doi.org/10.1038/s41421-024-00679-8 | |
| 8GY7 | A | Peptide | Melanocortin | MC2 | Homo sapiens | Corticotropin | Ca | chim(NtGi1-Gs)/β1/γ2; MRAP1 | 3.3 | 2023-01-11 | doi.org/10.1038/s41422-022-00751-6 | |
| 8IOC | A | Peptide | Melanocortin | MC3 | Homo sapiens | γ-MSH | Ca | chim(NtGi1-Gs)/β1/γ2 | 2.86 | 2023-09-20 | doi.org/10.1038/s41421-023-00586-4 | |
| 8W8W | A | Peptide | Melanocortin | MC3 | Homo sapiens | α-MSH | Ca | Gs/β1/γ2 | 2.9 | 2025-03-19 | To be published | |
| 8W8X | A | Peptide | Melanocortin | MC3 | Homo sapiens | β-MSH | Ca | Gs/β1/γ2 | 2.9 | 2025-03-19 | To be published | |
| 8W8Y | A | Peptide | Melanocortin | MC3 | Homo sapiens | γ-MSH | Ca | Gs/β1/γ2 | 2.9 | 2025-03-19 | To be published | |
| 8INR | A | Peptide | Melanocortin | MC5 | Homo sapiens | α-MSH | Ca | chim(NtGi1-Gs)/β1/γ2 | 2.73 | 2023-09-20 | doi.org/10.1038/s41421-023-00586-4 | |
| 8IOD | A | Peptide | Melanocortin | MC5 | Homo sapiens | PG-901 | Ca | chim(NtGi1-Gs)/β1/γ2 | 2.59 | 2023-09-20 | doi.org/10.1038/s41421-023-00586-4 | |
| 7F4D | A | Peptide | Melanocortin | MC1 | Homo sapiens | α-MSH | - | chim(NtGi1-Gs)/β1/γ2 | 3 | 2021-09-08 | doi.org/10.1038/s41422-021-00557-y | |
| 7F4F | A | Peptide | Melanocortin | MC1 | Homo sapiens | Afamelanotide | - | chim(NtGi1-Gs)/β1/γ2 | 2.9 | 2021-09-08 | doi.org/10.1038/s41422-021-00557-y | |
| 7F4H | A | Peptide | Melanocortin | MC1 | Homo sapiens | Afamelanotide | - | chim(NtGi1-Gs)/β1/γ2 | 2.7 | 2021-09-08 | doi.org/10.1038/s41422-021-00557-y | |
| 7F4I | A | Peptide | Melanocortin | MC1 | Homo sapiens | SHU9119 | - | chim(NtGi1-Gs)/β1/γ2 | 3.1 | 2021-09-08 | doi.org/10.1038/s41422-021-00557-y | |
| 7F53 | A | Peptide | Melanocortin | MC4 | Homo sapiens | α-MSH | - | Gs/β1/γ2 | 3 | 2021-11-03 | doi.org/10.1038/s41422-021-00552-3 | |
| 7F54 | A | Peptide | Melanocortin | MC4 | Homo sapiens | Afamelanotide | - | Gs/β1/γ2 | 3 | 2021-11-03 | doi.org/10.1038/s41422-021-00552-3 | |
| 7F55 | A | Peptide | Melanocortin | MC4 | Homo sapiens | Bremelanotide | - | Gs/β1/γ2 | 3.1 | 2021-11-03 | doi.org/10.1038/s41422-021-00552-3 | |
| 7F58 | A | Peptide | Melanocortin | MC4 | Homo sapiens | THIQ | - | Gs/β1/γ2 | 3.1 | 2021-11-03 | doi.org/10.1038/s41422-021-00552-3 | |
| 7PIU | A | Peptide | Melanocortin | MC4 | Homo sapiens | Setmelanotide | - | Gs/β1/γ2 | 2.58 | 2021-11-17 | doi.org/10.1038/s41422-021-00569-8 | |
| 7PIV | A | Peptide | Melanocortin | MC4 | Homo sapiens | Setmelanotide | - | Gs/β1/γ2 | 2.86 | 2021-11-17 | doi.org/10.1038/s41422-021-00569-8 | |
| 7AUE | A | Peptide | Melanocortin | MC4 | Homo sapiens | Setmelanotide | - | chim(NtGi1L-Gs)/β1/γ2 | 2.97 | 2021-04-28 | doi.org/10.1126/science.abf7958 | |
| 8QJ2 | A | Peptide | Melanocortin | MC4 | Homo sapiens | pN162 | - | Gs | 3.4 | 2024-09-25 | doi.org/10.1038/s41467-024-50827-7 | |
| 7VGY | A | Melatonin | Melatonin | MT1 | Homo sapiens | 2-Iodomelatonin | - | Gi1/β1/γ2 | 3.1 | 2022-03-02 | doi.org/10.1038/s41467-022-28111-3 | |
| 7VGZ | A | Melatonin | Melatonin | MT1 | Homo sapiens | Remalteon | - | Gi1/β1/γ2 | 3.3 | 2022-03-02 | doi.org/10.1038/s41467-022-28111-3 | |
| 7DB6 | A | Melatonin | Melatonin | MT1 | Homo sapiens | Ramelteon | - | Gi1/β1/γ2 | 3.3 | 2021-08-18 | doi.org/10.1038/s41594-021-00634-1 | |
| 7VH0 | A | Melatonin | Melatonin | MT2 | Homo sapiens | Ramelteon | - | Gi1/β1/γ1 | 3.46 | 2022-03-02 | doi.org/10.1038/s41467-022-28111-3 | |
| 8JD6 | C | Aminoacid | Metabotropic Glutamate | mGlu4; mGlu4 | Homo sapiens | Phosphoserine | VU0364770 | Gi3/β1/γ2 | 3.4 | 2023-06-21 | doi.org/10.1038/s41422-023-00830-2 | |
| 8WGB | C | Aminoacid | Metabotropic Glutamate | mGlu4; mGlu2 | Homo sapiens | Glutammate | VU0155041 | Gi3/β1/γ2 | 3.7 | 2024-10-30 | doi.org/10.1038/s41467-024-54744-7 | |
| 8JD5 | C | Aminoacid | Metabotropic Glutamate | mGlu2; mGlu4 | Homo sapiens | Glutamate | JNJ-40411813; ADX88178 | Gi1/β1/γ2 | 3.6 | 2023-06-21 | doi.org/10.1038/s41422-023-00830-2 | |
| 7E9G | C | Aminoacid | Metabotropic Glutamate | mGlu2; mGlu2 | Homo sapiens | Eglumetad | JNJ-40411813 | Gi1/β1/γ2 | 3.5 | 2021-06-23 | doi.org/10.1038/s41586-021-03495-2 | |
| 8JD3 | C | Aminoacid | Metabotropic Glutamate | mGlu2; mGlu3 | Homo sapiens | Glutamate | JNJ-40411813 | Gi1/β1/γ2 | 3.3 | 2023-06-21 | doi.org/10.1038/s41422-023-00830-2 | |
| 7MTS | C | Aminoacid | Metabotropic Glutamate | mGlu2; mGlu2 | Homo sapiens | Glutamate | ADX55164 | Gi1/β1/γ2 | 3.2 | 2021-07-07 | doi.org/10.1038/s41586-021-03680-3 | |
| 7E9H | C | Aminoacid | Metabotropic Glutamate | mGlu4; mGlu4 | Homo sapiens | Phosphoserine | - | Gi3/β1/γ2 | 4 | 2021-06-23 | doi.org/10.1038/s41586-021-03495-2 | |
| 8IBU | A | Peptide | Motilin | Motilin | Homo sapiens | Erythromycin-A | - | chim(NtGi1-Gs-CtGq)/β1/γ2 | 3.51 | 2023-04-12 | doi.org/10.1126/sciadv.ade9020 | |
| 8IBV | A | Peptide | Motilin | Motilin | Homo sapiens | Motilin | - | chim(NtGi1-Gs-CtGq)/β1/γ2 | 3.19 | 2023-04-12 | doi.org/10.1126/sciadv.ade9020 | |
| 9JMC | A | Peptide | Motilin | Motilin | Homo sapiens | DS-3801b | - | chim(Gs-CtGq)/β1/γ2 | 2.57 | 2025-05-28 | doi.org/10.1016/j.celrep.2025.115329 | |
| 9JMD | A | Peptide | Motilin | Motilin | Homo sapiens | Azithromycin | - | chim(Gs-CtGq)/β1/γ2 | 2.74 | 2025-05-28 | doi.org/10.1016/j.celrep.2025.115329 | |
| 7W53 | A | Peptide | Neuromedin U | NMUR1 | Homo sapiens | Neuromedin-U-25 | - | chim(NtGi1-Gs-CtGq)/β1/γ2 | 3.2 | 2022-04-20 | doi.org/10.1038/s41467-022-29683-w | |
| 7W56 | A | Peptide | Neuromedin U | NMUR1 | Homo sapiens | Neuromedin-S | - | chim(NtGi1-Gs-CtGq)/β1/γ2 | 2.9 | 2022-04-20 | doi.org/10.1038/s41467-022-29683-w | |
| 7W55 | A | Peptide | Neuromedin U | NMUR2 | Homo sapiens | Neuromedin-U-25 | - | chim(NtGi1-Gs-CtGq)/β1/γ2 | 2.8 | 2022-04-20 | doi.org/10.1038/s41467-022-29683-w | |
| 7W57 | A | Peptide | Neuromedin U | NMUR2 | Homo sapiens | Neuromedin-S | - | chim(NtGi1-Gs-CtGq)/β1/γ2 | 3.2 | 2022-04-20 | doi.org/10.1038/s41467-022-29683-w | |
| 7XK8 | A | Peptide | Neuromedin U | NMUR2 | Homo sapiens | Neuromedin-U-25 | - | Gi1/β1/γ2 | 3.3 | 2023-02-22 | doi.org/10.1038/s41467-022-34814-4 | |
| 9JFY | A | Peptide | Neuropeptide FF | NPFF2 | Homo sapiens | hNPSF | - | Gi1/β1/γ2 | 3.21 | 2025-04-09 | doi.org/10.1038/s44319-025-00428-2 | |
| 7VGX | A | Peptide | Neuropeptide Y | Y1 | Homo sapiens | Neuropeptide-Y | - | Gi1/β1/γ2 | 3.2 | 2022-02-23 | doi.org/10.1038/s41467-022-28510-6 | |
| 7X9A | A | Peptide | Neuropeptide Y | Y1 | Homo sapiens | Neuropeptide-Y | - | Gi1/β1/γ2 | 3.2 | 2022-05-18 | doi.org/10.1126/sciadv.abm1232 | |
| 8K6M | A | Peptide | Neuropeptide Y | Y1 | Homo sapiens | Neuropeptide-Y | - | Gi2/β1/γ1 | 3.3 | 2024-07-31 | doi.org/10.1002/mco2.565 | |
| 8K6O | A | Peptide | Neuropeptide Y | Y1 | Homo sapiens | Pro-neuropeptide-Y | - | Gi2/β1/γ1 | 3.3 | 2024-07-31 | doi.org/10.1002/mco2.565 | |
| 7YON | A | Peptide | Neuropeptide Y | Y2 | Homo sapiens | Peptide-YY(3-36) | - | Gi1/β1/γ2 | 2.95 | 2023-03-22 | doi.org/10.1016/j.str.2022.11.010 | |
| 7YOO | A | Peptide | Neuropeptide Y | Y2 | Homo sapiens | Neuropeptide-Y | - | Gi1/β1/γ2 | 3.11 | 2023-03-22 | doi.org/10.1016/j.str.2022.11.010 | |
| 7X9B | A | Peptide | Neuropeptide Y | Y2 | Homo sapiens | Neuropeptide-Y | - | Gi1/β1/γ2 | 3.4 | 2022-05-18 | doi.org/10.1126/sciadv.abm1232 | |
| 8K6N | A | Peptide | Neuropeptide Y | Y2 | Homo sapiens | Pro-neuropeptide-Y | - | Gi2/β1/γ1 | 3.2 | 2024-07-31 | doi.org/10.1002/mco2.565 | |
| 7X9C | A | Peptide | Neuropeptide Y | Y4 | Homo sapiens | Pancreatic Hormone | - | Gi1/β1/γ2 | 3 | 2022-05-18 | doi.org/10.1126/sciadv.abm1232 | |
| 8JPB | A | Peptide | Neurotensin | NTS1 | Homo sapiens | Neurotensin-(8-13) | SBI-553; GDP; Mg | Gq; GRK2 | 3.07 | 2023-08-09 | doi.org/10.1038/s41586-023-06395-9 | |
| 8JPC | A | Peptide | Neurotensin | NTS1 | Homo sapiens | Neurotensin-(8-13) | SBI-553; GDP; Mg | Gq; GRK2 | 3.07 | 2023-08-09 | doi.org/10.1038/s41586-023-06395-9 | |
| 8FN0 | A | Peptide | Neurotensin | NTS1 | Rattus norvegicus | Neurotensin/Neuromedin-N | SBI-553 | chim(NtGi1-Go)/β1/γ2 | 2.89 | 2023-03-29 | doi.org/10.1021/acs.biochem.3c00029 | |
| 8FMZ | A | Peptide | Neurotensin | NTS1 | Rattus norvegicus | Neurotensin/Neuromedin-N | - | chim(NtGi2L-Gs-CtGq)/β1/γ2 | 2.59 | 2023-03-29 | doi.org/10.1021/acs.biochem.3c00029 | |
| 8FN1 | A | Peptide | Neurotensin | NTS1 | Rattus norvegicus | Neurotensin/Neuromedin-N | - | chim(NtGi1-Go)/β1/γ2 | 2.88 | 2023-03-29 | doi.org/10.1021/acs.biochem.3c00029 | |
| 6OS9 | A | Peptide | Neurotensin | NTS1 | Homo sapiens | JMV449 | - | Gi1/β1/γ2 | 3 | 2019-07-10 | doi.org/10.1038/s41586-019-1337-6 | |
| 6OSA | A | Peptide | Neurotensin | NTS1 | Homo sapiens | JMV449 | - | Gi1/β1/γ2 | 3 | 2019-07-10 | doi.org/10.1038/s41586-019-1337-6 | |
| 7L0P | A | Peptide | Neurotensin | NTS1 | Rattus norvegicus | Neurotensin | - | Gi1/β1/γ1 | 4.1 | 2021-01-06 | doi.org/10.1038/s41594-020-00554-6 | |
| 7L0Q | A | Peptide | Neurotensin | NTS1 | Rattus norvegicus | Neurotensin | - | Gi1/β1/γ1 | 4.3 | 2021-01-06 | doi.org/10.1038/s41594-020-00554-6 | |
| 7L0R | A | Peptide | Neurotensin | NTS1 | Rattus norvegicus | Neurotensin | - | Gi1/β1/γ1 | 4.2 | 2021-01-06 | doi.org/10.1038/s41594-020-00554-6 | |
| 7L0S | A | Peptide | Neurotensin | NTS1 | Rattus norvegicus | Neurotensin | - | Gi1/β1/γ1 | 4.5 | 2021-01-06 | doi.org/10.1038/s41594-020-00554-6 | |
| 8UXY | O2 | Odorant receptors | Odorant family 1 | consOR1 | Homo sapiens | L-menthol | - | Gs/β1/γ2 | 3.3 | 2024-10-30 | doi.org/10.1038/s41586-024-08126-0 | |
| 8UY0 | O2 | Odorant receptors | Odorant family 2 | consOR2 | Homo sapiens | S-carvone | - | Gs/β1/γ2 | 3.2 | 2024-10-30 | doi.org/10.1038/s41586-024-08126-0 | |
| 8UYQ | O2 | Odorant receptors | Odorant family 4 | consOR4 | Homo sapiens | 2-methylthiazoline | - | Gs/β1/γ2 | 3.5 | 2024-10-30 | doi.org/10.1038/s41586-024-08126-0 | |
| 8UXV | O1 | Odorant receptors | Odorant family 51 | consOR51 | Homo sapiens | - | - | Gs/β1/γ2 | 3.2 | 2024-10-30 | doi.org/10.1038/s41586-024-08126-0 | |
| 8F76 | O1 | Odorant receptors | Odorant family 51 | OR51E2 | Homo sapiens | Propanoic acid | - | Gs/β1/γ2 | 3.1 | 2023-03-22 | doi.org/10.1038/s41586-023-05798-y | |
| 8HTI | O1 | Odorant receptors | Odorant family 52 | OR52C | Homo sapiens | Ocatnoic acid | - | Gs/β1/γ2 | 2.97 | 2023-12-20 | doi.org/10.1038/s41467-023-43983-9 | |
| 8K9L | A | Peptide | Opioid | μ | Homo sapiens | Damgo | BMS-986122 | Gi3/β1/γ1 | 3.05 | 2024-05-29 | doi.org/10.1038/s41467-024-47792-6 | |
| 8F7S | A | Peptide | Opioid | δ | Homo sapiens | Deltorphin | - | Gi1/β1/γ2 | 3 | 2022-12-14 | doi.org/10.1016/j.cell.2022.12.026 | |
| 8Y45 | A | Peptide | Opioid | δ | Homo sapiens | ADL5859 | - | Gi2/β1/γ2 | 3.45 | 2024-11-27 | doi.org/10.1038/s41467-024-52601-1 | |
| 9CGJ | A | Peptide | Opioid | δ | Homo sapiens | C6-Quino | - | Gi1/β1/γ2 | 2.8 | 2025-04-02 | doi.org/10.1038/s41467-025-57734-5 | |
| 9CGK | A | Peptide | Opioid | δ | Homo sapiens | C5-Quino | - | Gi1/β1/γ2 | 2.62 | 2025-04-02 | doi.org/10.1038/s41467-025-57734-5 | |
| 8F7W | A | Peptide | Opioid | κ | Homo sapiens | Dynorphin | - | Gi1/β1/γ2 | 3.19 | 2022-12-14 | doi.org/10.1016/j.cell.2022.12.026 | |
| 8FEG | A | Peptide | Opioid | κ | Homo sapiens | (DNCP)-β-Naloxamine | - | Gi1/β1/γ2 | 2.54 | 2023-12-06 | doi.org/10.1038/s41467-023-43718-w | |
| 8DZP | A | Peptide | Opioid | κ | Homo sapiens | momSalB | - | Gi1/β1/γ2 | 2.71 | 2023-05-03 | doi.org/10.1038/s41586-023-06030-7 | |
| 8DZQ | A | Peptide | Opioid | κ | Homo sapiens | momSalB | - | Go/β1/γ2 | 2.82 | 2023-05-03 | doi.org/10.1038/s41586-023-06030-7 | |
| 8DZR | A | Peptide | Opioid | κ | Homo sapiens | GR89,696 | - | chim(NtGi2-Gt3)/β1/γ2 | 2.61 | 2023-05-03 | doi.org/10.1038/s41586-023-06030-7 | |
| 8DZS | A | Peptide | Opioid | κ | Homo sapiens | GR89,696 | - | chim(NtGi2-Gz)/β1/γ2 | 2.65 | 2023-05-03 | doi.org/10.1038/s41586-023-06030-7 | |
| 7Y1F | A | Peptide | Opioid | κ | Homo sapiens | Dynorphin | - | Gi1/β1/γ2 | 3.3 | 2023-05-24 | doi.org/10.1093/procel/pwac033 | |
| 8VVE | A | Peptide | Opioid | κ | Homo sapiens | norBNI | - | Gi1/β1/γ2 | 3.3 | 2025-01-15 | doi.org/10.1038/s41589-024-01812-0 | |
| 8VVF | A | Peptide | Opioid | κ | Homo sapiens | JDTic | - | Gi1/β1/γ2 | 3 | 2025-01-15 | doi.org/10.1038/s41589-024-01812-0 | |
| 8VVG | A | Peptide | Opioid | κ | Homo sapiens | GB18 | - | Gi1/β1/γ2 | 3.3 | 2025-01-15 | doi.org/10.1038/s41589-024-01812-0 | |
| 9D61 | A | Peptide | Opioid | κ | Homo sapiens | JDTic | - | Gi1/β1/γ2 | 3.58 | 2025-01-15 | doi.org/10.1038/s41589-024-01812-0 | |
| 7SBF | A | Peptide | Opioid | μ | Mus musculus | PZM21 | - | Gi1/β1/γ2 | 2.9 | 2022-04-20 | doi.org/10.1002/anie.202200269 | |
| 7SCG | A | Peptide | Opioid | μ | Mus musculus | FH210 | - | Gi1/β1/γ2 | 3 | 2022-04-20 | doi.org/10.1002/anie.202200269 | |
| 8EF5 | A | Peptide | Opioid | μ | Homo sapiens | Fentanyl | - | Gi1/β1/γ2 | 3.3 | 2022-11-09 | doi.org/10.1016/j.cell.2022.09.041 | |
| 8EF6 | A | Peptide | Opioid | μ | Homo sapiens | Morphine | - | Gi1/β1/γ2 | 3.2 | 2022-11-09 | doi.org/10.1016/j.cell.2022.09.041 | |
| 8EFB | A | Peptide | Opioid | μ | Homo sapiens | Oliceridine | - | Gi1/β1/γ2 | 3.2 | 2022-11-09 | doi.org/10.1016/j.cell.2022.09.041 | |
| 8EFL | A | Peptide | Opioid | μ | Homo sapiens | SR17018 | - | Gi1/β1/γ2 | 3.2 | 2022-11-09 | doi.org/10.1016/j.cell.2022.09.041 | |
| 8EFO | A | Peptide | Opioid | μ | Homo sapiens | PZM21 | - | Gi1/β1/γ2 | 2.8 | 2022-11-09 | doi.org/10.1016/j.cell.2022.09.041 | |
| 8EFQ | A | Peptide | Opioid | μ | Homo sapiens | Damgo | - | Gi1/β1/γ2 | 3.3 | 2022-11-09 | doi.org/10.1016/j.cell.2022.09.041 | |
| 8F7Q | A | Peptide | Opioid | μ | Homo sapiens | β-Endorphin | - | Gi1/β1/γ2 | 3.22 | 2022-12-14 | doi.org/10.1016/j.cell.2022.12.026 | |
| 8F7R | A | Peptide | Opioid | μ | Homo sapiens | Endomorphin | - | Gi1/β1/γ2 | 3.28 | 2022-12-14 | doi.org/10.1016/j.cell.2022.12.026 | |
| 9BQJ | A | Peptide | Opioid | μ | Mus musculus | RO76 | - | Gi1/β1/γ2 | 3.3 | 2024-09-11 | doi.org/10.1021/acscentsci.4c00525 | |
| 8K9K | A | Peptide | Opioid | μ | Homo sapiens | Damgo | - | Gi3/β1/γ1 | 2.98 | 2024-05-29 | doi.org/10.1038/s41467-024-47792-6 | |
| 6DDE | A | Peptide | Opioid | μ | Mus musculus | Damgo | - | Gi1/β1/γ2 | 3.5 | 2018-06-13 | doi.org/10.1038/s41586-018-0219-7 | |
| 6DDF | A | Peptide | Opioid | μ | Mus musculus | Damgo | - | Gi1/β1/γ2 | 3.5 | 2018-06-13 | doi.org/10.1038/s41586-018-0219-7 | |
| 7U2L | A | Peptide | Opioid | μ | Mus musculus | PubChem 163201242 | - | Gi1/β1/γ2 | 3.2 | 2022-05-04 | doi.org/10.1038/s41586-022-05588-y | |
| 7U2K | A | Peptide | Opioid | μ | Mus musculus | C6-guano | - | Gi1/β1/γ2 | 3.3 | 2022-12-07 | doi.org/10.1038/s41586-022-05588-y | |
| 7T2G | A | Peptide | Opioid | μ | Mus musculus | Mitragynine Pseudoindoxyl | - | Gi1/β1/γ2 | 2.5 | 2022-12-07 | doi.org/10.1038/s41589-022-01208-y | |
| 7T2H | A | Peptide | Opioid | μ | Mus musculus | Lofentanil | - | Gi1/β1/γ2 | 2.5 | 2022-12-07 | doi.org/10.1038/s41589-022-01208-y | |
| 8F7X | A | Peptide | Opioid | NOP | Homo sapiens | Nociceptin | - | Gi1/β1/γ2 | 3.28 | 2022-12-14 | doi.org/10.1016/j.cell.2022.12.026 | |
| 8P13 | A | Sensory | Opsin | Rhodopsin | Bos taurus | - | - | Gi1/β1/γT1 | 5.2 | 2024-11-20 | To be published | |
| 8P15 | A | Sensory | Opsin | Rhodopsin | Bos taurus | - | - | Gi1/β1/γT1 | 5.9 | 2024-11-20 | To be published | |
| 6PH7 | A | Sensory | Opsins | Rhodopsin | Bos taurus | - | Nerol | Gt(CT) | 2.9 | 2020-07-01 | To be published | |
| 6PGS | A | Sensory | Opsins | Rhodopsin | Bos taurus | - | Geraniol | Gt(CT) | 2.9 | 2020-07-01 | To be published | |
| 6PEL | A | Sensory | Opsins | Rhodopsin | Bos taurus | - | Citronellol | Gt(CT) | 3.19 | 2020-06-24 | To be published | |
| 8Y02 | A | Sensory | Opsins | OPN1SW | Homo sapiens | Retinal | - | Gi1/β1/γ2 | 2.61 | 2025-06-11 | To be published | |
| 8IU2 | A | Sensory | Opsins | Opsin1LW | Homo sapiens | Retinal | - | Gi1/β1/γ2 | 3.35 | 2024-03-27 | To be published | |
| 8Y01 | A | Sensory | Opsins | Opsin1MW | Homo sapiens | Retinal | - | Gi1/β1/γ2 | 2.48 | 2025-02-12 | To be published | |
| 4J4Q | A | Sensory | Opsins | Rhodopsin | Bos taurus | Octyl β-D-Glucopyranoside | - | Gt(CT) | 2.65 | 2013-10-30 | doi.org/10.1002/anie.201302374 | |
| 6OY9 | A | Sensory | Opsins | Rhodopsin | Bos taurus | All-trans-Retinal | - | Gt/β1/γ1 | 3.9 | 2019-07-24 | doi.org/10.1016/j.molcel.2019.06.007 | |
| 6OYA | A | Sensory | Opsins | Rhodopsin | Bos taurus | All-trans-Retinal | - | Gt/β1/γ1 | 3.3 | 2019-07-24 | doi.org/10.1016/j.molcel.2019.06.007 | |
| 4X1H | A | Sensory | Opsins | Rhodopsin | Bos taurus | Nonyl-β-D-Glucopyranoside | - | Gt(CT) | 2.29 | 2015-11-04 | doi.org/10.1016/j.str.2015.09.015 | |
| 4BEY | A | Sensory | Opsins | Rhodopsin | Bos taurus | - | - | Gt(CT) | 2.9 | 2013-05-08 | doi.org/10.1038/embor.2013.44 | |
| 3DQB | A | Sensory | Opsins | Rhodopsin | Bos taurus | - | - | Gt(CT) | 3.2 | 2008-09-23 | doi.org/10.1038/nature07330 | |
| 3PQR | A | Sensory | Opsins | Rhodopsin | Bos taurus | All-trans-Retinal | - | Gt(CT) | 2.85 | 2011-03-09 | doi.org/10.1038/nature09789 | |
| 2X72 | A | Sensory | Opsins | Rhodopsin | Bos taurus | All-trans-Retinal | - | Gt(CT) | 3 | 2011-03-16 | doi.org/10.1038/nature09795 | |
| 5WKT | A | Sensory | Opsins | Rhodopsin | Bos taurus | Octyl-β-D-Glucopyranoside | - | Gt(CT) | 3.2 | 2017-12-13 | doi.org/10.1038/nprot.2017.135 | |
| 9EPP | A | Sensory | Opsins | Rhodopsin | Hasarius adansoni | 11,20-Ethanoretinal | - | chim(Gi1-CtGq)/β1/γ2 | 4.06 | 2024-10-23 | doi.org/10.1038/s41467-024-53208-2 | |
| 9EPQ | A | Sensory | Opsins | Rhodopsin | Hasarius adansoni | 11,20-Ethanoretinal | - | chim(Gi1-CtGq)/β1/γ2 | 4.15 | 2024-10-23 | doi.org/10.1038/s41467-024-53208-2 | |
| 6CMO | A | Sensory | Opsins | Rhodopsin | Homo sapiens | - | - | Gi1/β1/γ2 | 4.5 | 2018-06-20 | doi.org/10.1038/s41586-018-0215-y | |
| 4A4M | A | Sensory | Opsins | Rhodopsin | Bos taurus | All-trans-Retinal | - | Gt(CT) | 3.3 | 2012-01-25 | doi.org/10.1073/pnas.1114089108 | |
| 6FUF | A | Sensory | Opsins | Rhodopsin | Bos taurus | All-trans-Retinal | - | Go | 3.12 | 2018-10-03 | doi.org/10.1126/sciadv.aat7052 | |
| 5EN0 | A | Sensory | Opsins | Rhodopsin | Bos taurus | All-trans-Retinal | - | Gt(CT) | 2.81 | 2016-08-10 | doi.org/10.15252/embr.201642671 | |
| 6QNO | A | Sensory | Opsins | Rhodopsin | Bos taurus | All-trans-Retinal | - | Gi1/β1/γ1 | 4.38 | 2019-07-10 | doi.org/10.7554/eLife.46041 | |
| 9EPR | A | Sensory | Opsins | Rhodopsin | Hasarius adansoni | Retinal | - | Gi1/β1/γ2 | 4.9 | 2024-10-30 | doi.org/10.1038/s41467-024-53208-2 | |
| 6NWE | A | Sensory | Opsins | Rhodopsin | Bos taurus | Octyl-β-D-Glucopyranoside | - | Gt(CT) | 2.71 | 2020-02-12 | To be published | |
| 8P12 | A | Sensory | Opsins | Rhodopsin | Bos taurus | - | - | Gi1/β1/γT1 | 3.21 | 2024-11-20 | To be published | |
| 7L1U | A | Peptide | Orexin | OX2 | Homo sapiens | Orexin | - | chim(NtGi1-Gs-CtGq)/β1/γ2 | 3.2 | 2021-02-10 | doi.org/10.1038/s41467-021-21087-6 | |
| 7L1V | A | Peptide | Orexin | OX2 | Homo sapiens | PubChem 155491009 | - | chim(NtGi1-Gs-CtGq)/β1/γ2 | 3 | 2021-02-10 | doi.org/10.1038/s41467-021-21087-6 | |
| 7SQO | A | Peptide | Orexin | OX2 | Homo sapiens | TAK-925 | - | Gi1/β1/γ2 | 3.17 | 2022-05-25 | doi.org/10.1038/s41467-022-30601-3 | |
| 7SR8 | A | Peptide | Orexin | OX2 | Homo sapiens | TAK-925 | - | chim(NtGi1L-Gs-CtGq)/β1/γ2 | 3.3 | 2022-06-08 | doi.org/10.1038/s41467-022-30601-3 | |
| 8DWG | A | Orphan | Orphan | MRGPRX1 | Homo sapiens | Proenkephalin-A | ML382 | chim(NtGi2L-Gs-CtGq)/β1/γ2 | 2.71 | 2022-11-02 | doi.org/10.1038/s41589-022-01173-6 | |
| 9JCP | A | Orphan | Orphan | GPR4 | Homo sapiens | - | LPC | chim(NtGi1-Gs-CtGq)/β1/γ2 | 2.55 | 2025-07-09 | doi.org/10.1038/s41421-025-00807-y | |
| 9JCO | A | Orphan | Orphan | GPR4 | Homo sapiens | - | LPC | chim(NtGi1-Gs)/β1/γ2 | 2.36 | 2025-07-09 | doi.org/10.1038/s41421-025-00807-y | |
| 9JCQ | A | Orphan | Orphan | GPR4 | Homo sapiens | - | LPC | chim(NtGi1-Gs)/β1/γ2 | 2.59 | 2025-07-09 | doi.org/10.1038/s41421-025-00807-y | |
| 7VUI | A | Orphan | Orphan | GPR139 | Homo sapiens | JNJ-63533054 | GTP | chim(Gs-CtGq)/β1/γ2 | 3.3 | 2021-12-29 | doi.org/10.1038/s41422-021-00591-w | |
| 7VUJ | A | Orphan | Orphan | GPR139 | Homo sapiens | JNJ-63533054 | GDP | chim(Gs-CtGq)/β1/γ2 | 3.8 | 2021-12-29 | doi.org/10.1038/s41422-021-00591-w | |
| 8H8J | A | Orphan | Orphan | GPR35 | Homo sapiens | Lodoxamide | Ca | chim(NtGi1L-G13)/β1/γ2 | 3.2 | 2023-02-08 | doi.org/10.1038/s41421-022-00499-8 | |
| 8HMP | A | Orphan | Orphan | GPR52 | Homo sapiens | - | C17 | Gs/β1/γ2 | 2.77 | 2023-06-21 | doi.org/10.1002/mco2.260 | |
| 8W8R | A | Orphan | Orphan | GPR101 | Homo sapiens | - | AA-14 | chim(NtGi1-Gs)/β1/γ2 | 3.3 | 2024-01-03 | doi.org/10.1038/s41589-023-01456-6 | |
| 7EJX | A | Orphan | Orphan | GPR88 | Homo sapiens | - | (1R;2R)-2-PCCA | Gi1/β1/γ2 | 2.4 | 2022-04-13 | doi.org/10.1038/s41467-022-30081-5 | |
| 8W8Q | A | Orphan | Orphan | GPR101 | Homo sapiens | - | - | Gs/β1/γ2 | 2.89 | 2024-01-03 | doi.org/10.1038/s41589-023-01456-6 | |
| 7Y3G | A | Orphan | Orphan | GPR12 | Homo sapiens | - | - | Gs/β1/γ2 | 2.77 | 2023-06-07 | doi.org/10.1016/j.scib.2022.12.023 | |
| 8HQE | A | Orphan | Orphan | GPR132 | Homo sapiens | - | - | Gi1/β1/γ2 | 2.97 | 2023-10-11 | doi.org/10.1038/s42255-023-00899-4 | |
| 8HQM | A | Orphan | Orphan | GPR132 | Homo sapiens | NPGLY | - | Gi1/β1/γ2 | 2.95 | 2023-10-11 | doi.org/10.1038/s42255-023-00899-4 | |
| 8HQN | A | Orphan | Orphan | GPR132 | Homo sapiens | 9-S-HODE | - | Gi1/β1/γ2 | 3 | 2023-10-11 | doi.org/10.1038/s42255-023-00899-4 | |
| 8HVI | A | Orphan | Orphan | GPR132 | Homo sapiens | NOX-6-7 | - | Gi1/β1/γ2 | 3.04 | 2023-10-11 | doi.org/10.1038/s42255-023-00899-4 | |
| 7VUG | A | Orphan | Orphan | GPR139 | Homo sapiens | JNJ-63533054 | - | Gi1/β1/γ2 | 3.2 | 2021-12-29 | doi.org/10.1038/s41422-021-00591-w | |
| 7VUH | A | Orphan | Orphan | GPR139 | Homo sapiens | JNJ-63533054 | - | chim(Gs-CtGq)/β1/γ2 | 3.22 | 2021-12-29 | doi.org/10.1038/s41422-021-00591-w | |
| 8ZQE | A | Orphan | Orphan | GPR15 | Homo sapiens | GPR15L(C11) | - | Gi1/β1/γ1 | 2.9 | 2024-07-10 | doi.org/10.1038/s41421-024-00698-5 | |
| 8KH4 | A | Orphan | Orphan | GPR161 | Homo sapiens | - | - | Gs/β1/γ2 | 3.1 | 2023-10-11 | doi.org/10.1038/s41467-023-41654-3 | |
| 8SMV | A | Orphan | Orphan | GPR161 | Homo sapiens | - | - | Gs/β1/γ2 | 2.74 | 2024-02-21 | doi.org/10.1038/s41594-024-01223-8 | |
| 7Y89 | A | Orphan | Orphan | GPR17 (CysLT) | Homo sapiens | - | - | Gi1/β1/γ2 | 3.02 | 2022-10-12 | doi.org/10.1002/mco2.159 | |
| 7XV3 | A | Orphan | Orphan | GPR174 | Homo sapiens | Lysophosphatidylserine | - | chim(NtGi1-Gs)/β1/γ2 | 2.76 | 2023-02-15 | doi.org/10.1038/s41467-023-36575-0 | |
| 8KH5 | A | Orphan | Orphan | GPR174 | Homo sapiens | Lysophosphatidylserine | - | Gs/β1/γ2 | 2.83 | 2023-10-11 | doi.org/10.1038/s41467-023-41654-3 | |
| 8IZB | A | Orphan | Orphan | GPR174 | Homo sapiens | Lysophosphatidylserine | - | Gs/β1/γ2 | 3.06 | 2023-11-01 | doi.org/10.1371/journal.pbio.3002387 | |
| 7TUZ | A | Orphan | Orphan | GPR183 | Homo sapiens | 7-α,25-dihydroxycholesterol | - | Gi1/β1/γ2 | 3.12 | 2022-04-13 | doi.org/10.1016/j.str.2022.04.006 | |
| 8HS3 | A | Orphan | Orphan | GPR20 | Homo sapiens | - | - | Gi1/β1/γ2 | 3.14 | 2023-03-08 | doi.org/10.1038/s41421-023-00520-8 | |
| 8HSC | A | Orphan | Orphan | GPR20 | Homo sapiens | Fab046 | - | Gi1/β1/γ2 | 3.22 | 2023-03-08 | doi.org/10.1038/s41421-023-00520-8 | |
| 8HMV | A | Orphan | Orphan | GPR21 | Homo sapiens | - | - | Gs/β1/γ2 | 2.91 | 2023-03-01 | doi.org/10.1002/mco2.205 | |
| 8HIX | A | Orphan | Orphan | GPR21 | Homo sapiens | - | - | Gs/β1/γ2 | 3.12 | 2023-03-15 | doi.org/10.1038/s41467-023-35882-w | |
| 8HJ0 | A | Orphan | Orphan | GPR21 | Homo sapiens | - | - | chim(Gs-CtG15)/β1/γ2 | 3.12 | 2023-03-15 | doi.org/10.1038/s41467-023-35882-w | |
| 8HJ2 | A | Orphan | Orphan | GPR21 | Homo sapiens | - | - | chim(Gs-CtG15)/β1/γ2 | 3.8 | 2023-03-15 | doi.org/10.1038/s41467-023-35882-w | |
| 8HJ1 | A | Orphan | Orphan | GPR21 | Homo sapiens | - | - | Gs/β1/γ2 | 3.27 | 2023-12-27 | doi.org/10.1038/s41467-023-35882-w | |
| 8U8F | A | Orphan | Orphan | GPR3 | Homo sapiens | Palmitic Acid | - | Gs/β1/γ2 | 3.49 | 2024-03-06 | doi.org/10.1021/acs.biochem.3c00647 | |
| 8WW2 | A | Orphan | Orphan | GPR3 | Homo sapiens | - | - | chim(NtGi1-Gs)/β1/γ2 | 2.79 | 2024-02-14 | doi.org/10.1038/s41422-024-00932-5 | |
| 9LYB | A | Orphan | Orphan | GPR3 | Homo sapiens | - | - | Gs/β1/γ2 | 3.16 | 2025-04-09 | doi.org/10.1016/j.celrep.2025.115478 | |
| 9LYC | A | Orphan | Orphan | GPR3 | Homo sapiens | - | - | Gs/β1/γ2 | 3.06 | 2025-04-09 | doi.org/10.1016/j.celrep.2025.115478 | |
| 8X2K | A | Orphan | Orphan | GPR3 | Homo sapiens | Oleic monoethanolamide | - | chim(NtGi1-Gs)/β1/γ2 | 3.03 | 2024-04-03 | doi.org/10.1038/s41422-023-00919-8 | |
| 8XOF | A | Orphan | Orphan | GPR30 | Homo sapiens | Lys05 | - | chim(NtGi1-Gs-CtGq)/β1/γ2 | 2.6 | 2024-04-10 | doi.org/10.1038/s41422-024-00963-y | |
| 8XOG | A | Orphan | Orphan | GPR30 | Homo sapiens | - | - | chim(NtGi1-Gs-CtGq)/β1/γ2 | 2.9 | 2024-04-10 | doi.org/10.1038/s41422-024-00963-y | |
| 8XOH | A | Orphan | Orphan | GPR30 | Homo sapiens | - | - | chim(NtGi1-Gs-CtGq)/β1/γ2 | 3.2 | 2024-04-10 | doi.org/10.1038/s41422-024-00963-y | |
| 8XOI | A | Orphan | Orphan | GPR30 | Homo sapiens | - | - | chim(NtGi1-Gs-CtGq)/β1/γ2 | 3.2 | 2024-04-10 | doi.org/10.1038/s41422-024-00963-y | |
| 8XOJ | A | Orphan | Orphan | GPR30 | Homo sapiens | - | - | chim(NtGi1-Gs-CtGq)/β1/γ2 | 3.1 | 2024-04-10 | doi.org/10.1038/s41422-024-00963-y | |
| 8XBE | A | Orphan | Orphan | GPR34 | Homo sapiens | S3E-LysoPS | - | Gi1/β1/γ1 | 3.4 | 2024-05-15 | doi.org/10.1038/s41467-024-45046-z | |
| 8SAI | A | Orphan | Orphan | GPR34 | Homo sapiens | 1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine | - | Gi1/β1/γ2 | 3.27 | 2023-10-04 | doi.org/10.1073/pnas.2308435120 | |
| 8WRB | A | Orphan | Orphan | GPR34 | Homo sapiens | Lysophosphatidylserine | - | Gi1/β1/γ2 | 2.91 | 2023-11-08 | doi.org/10.1371/journal.pbio.3002387 | |
| 8XBH | A | Orphan | Orphan | GPR34 | Homo sapiens | S3E-LysoPS | - | Gi1/β1/γ2 | 2.83 | 2023-12-27 | doi.org/10.1038/s41467-024-45046-z | |
| 8K4N | A | Orphan | Orphan | GPR34 | Homo sapiens | VF0 | - | Gi1/β1/γ2 | 2.83 | 2023-10-25 | To be published | |
| 8IZ4 | A | Orphan | Orphan | GPR34 | Homo sapiens | Lysophosphatidylserine | - | Gi1/β1/γ2 | 2.94 | 2024-04-10 | To be published | |
| 8ZD1 | A | Orphan | Orphan | GPR4 | Xenopus tropicalis | - | - | chim(NtGi1-Gs)/β1/γ2 | 2.6 | 2025-02-26 | doi.org/10.1016/j.cell.2024.12.001 | |
| 8ZF6 | A | Orphan | Orphan | GPR4 | Xenopus tropicalis | - | - | chim(NtGi1-Gs)/β1/γ2 | 2.98 | 2025-02-26 | doi.org/10.1016/j.cell.2024.12.001 | |
| 8ZF9 | A | Orphan | Orphan | GPR4 | Mus musculus | - | - | chim(NtGi1-Gs)/β1/γ2 | 2.56 | 2025-02-26 | doi.org/10.1016/j.cell.2024.12.001 | |
| 8ZFA | A | Orphan | Orphan | GPR4 | Xenopus tropicalis | - | - | chim(NtGi1-Gs)/β1/γ2 | 2.96 | 2025-02-26 | doi.org/10.1016/j.cell.2024.12.001 | |
| 8ZFC | A | Orphan | Orphan | GPR4 | Mus musculus | - | - | chim(NtGi1-Gs)/β1/γ2 | 2.68 | 2025-02-26 | doi.org/10.1016/j.cell.2024.12.001 | |
| 9JVG | A | Orphan | Orphan | GPR4 | Mus musculus | - | - | chim(NtGi1-Gs)/β1/γ2 | 2.76 | 2025-02-26 | doi.org/10.1016/j.cell.2024.12.001 | |
| 9BIP | A | Orphan | Orphan | GPR4 | Homo sapiens | - | - | Gs/β1/γ2 | 2.8 | 2025-01-22 | doi.org/10.1016/j.cell.2024.11.036 | |
| 8ZCE | A | Orphan | Orphan | GPR4 | Homo sapiens | - | - | Gs/β1/γ2 | 3.1 | 2025-04-23 | doi.org/10.1038/s41422-025-01092-w | |
| 8ZCF | A | Orphan | Orphan | GPR4 | Homo sapiens | - | - | Gs/β1/γ2 | 2.9 | 2025-04-23 | doi.org/10.1038/s41422-025-01092-w | |
| 9JFV | A | Orphan | Orphan | GPR4 | Homo sapiens | - | - | chim(Gs-CtGq)/β1/γ2 | 2.67 | 2025-04-23 | doi.org/10.1038/s41422-025-01092-w | |
| 9JFW | A | Orphan | Orphan | GPR4 | Homo sapiens | - | - | Gs/β1/γ2 | 3.13 | 2025-04-23 | doi.org/10.1038/s41422-025-01092-w | |
| 9JFX | A | Orphan | Orphan | GPR4 | Homo sapiens | - | - | chim(Gs-CtGq)/β1/γ2 | 2.87 | 2025-04-23 | doi.org/10.1038/s41422-025-01092-w | |
| 9JFZ | A | Orphan | Orphan | GPR4 | Homo sapiens | - | - | chim(Gs-CtGq)/β1/γ2 | 2.9 | 2025-04-23 | doi.org/10.1038/s41422-025-01092-w | |
| 9JHP | A | Orphan | Orphan | GPR4 | Homo sapiens | - | - | chim(NtGi2-G13)/β1/γ2 | 3.35 | 2025-04-23 | doi.org/10.1038/s41422-025-01092-w | |
| 9LGM | A | Orphan | Orphan | GPR4 | Homo sapiens | - | - | Gs/β1/γ2 | 2.84 | 2025-04-23 | doi.org/10.1038/s41422-025-01092-w | |
| 8ZFZ | A | Orphan | Orphan | GPR4 | Danio rerio | - | - | chim(NtGi1-Gs)/β1/γ2 | 3.3 | 2025-01-22 | doi.org/10.1038/s41467-025-55901-2 | |
| 9J31 | A | Orphan | Orphan | GPR4 | Danio rerio | - | - | chim(NtGi1-Gs)/β1/γ2 | 3.05 | 2025-01-22 | doi.org/10.1038/s41467-025-55901-2 | |
| 8Z3M | A | Orphan | Orphan | GPR4 | Homo sapiens | - | - | chim(NtGi1-Gs-CtGq)/β1/γ2 | 2.9 | 2025-04-23 | To be published | |
| 8Z3Q | A | Orphan | Orphan | GPR4 | Homo sapiens | - | - | chim(NtGi1-Gs)/β1/γ2 | 2.76 | 2025-04-23 | To be published | |
| 8Z65 | A | Orphan | Orphan | GPR4 | Homo sapiens | - | - | chim(NtGi1-Gs)/β1/γ2 | 2.98 | 2025-04-23 | To be published | |
| 8Z3Y | A | Orphan | Orphan | GPR4 | Homo sapiens | - | - | chim(NtGi1-Gs)/β1/γ2 | 3.2 | 2025-06-04 | To be published | |
| 8Z9P | A | Orphan | Orphan | GPR4 | Homo sapiens | - | - | Gi1/β1/γ2 | 2.5 | 2025-07-09 | To be published | |
| 6LI3 | A | Orphan | Orphan | GPR52 | Homo sapiens | - | - | Gs/β1/γ2 | 3.32 | 2020-02-26 | doi.org/10.1038/s41586-020-2019-0 | |
| 9IY8 | A | Orphan | Orphan | GPR55 | Homo sapiens | - | - | chim(NtGi1-G13)/β1/γ2 | 3.01 | 2025-01-01 | doi.org/10.1038/s41422-024-01046-8 | |
| 9GE2 | A | Orphan | Orphan | GPR55 | Homo sapiens | ML184 | - | chim(NtGi1-G13)/β1/γ2 | 2.51 | 2025-03-05 | doi.org/10.1038/s41467-025-57204-y | |
| 9GE3 | A | Orphan | Orphan | GPR55 | Homo sapiens | Lysophosphatidylinositol | - | chim(NtGi1-G13)/β1/γ2 | 2.87 | 2025-03-05 | doi.org/10.1038/s41467-025-57204-y | |
| 8TYW | A | Orphan | Orphan | GPR6 | Homo sapiens | - | - | Gs/β1/γ2 | 3.43 | 2024-12-04 | doi.org/10.2210/pdb8TF5/pdb | |
| 8TB0 | A | Orphan | Orphan | GPR61 | Homo sapiens | - | - | chim(NtGi1-Gs)/β1/γ2 | 3.47 | 2023-10-04 | doi.org/10.1038/s41467-023-41646-3 | |
| 8KGK | A | Orphan | Orphan | GPR61 | Homo sapiens | - | - | Gs/β1/γ2 | 3.16 | 2023-10-11 | doi.org/10.1038/s41467-023-41654-3 | |
| 9BHL | A | Orphan | Orphan | GPR65 | Homo sapiens | - | - | Gs/β1 | 2.8 | 2025-01-22 | doi.org/10.1016/j.cell.2024.11.036 | |
| 9BHM | A | Orphan | Orphan | GPR68 | Homo sapiens | - | - | Gs/β1 | 2.9 | 2025-01-22 | doi.org/10.1016/j.cell.2024.11.036 | |
| 9BI6 | A | Orphan | Orphan | GPR68 | Homo sapiens | - | - | chim(Gs-CtGq)/β1/γ2 | 2.9 | 2025-01-22 | doi.org/10.1016/j.cell.2024.11.036 | |
| 8Z5H | A | Orphan | Orphan | GPR68 | Homo sapiens | - | - | chim(NtGi1-Gs)/β1/γ2 | 3.3 | 2025-04-23 | To be published | |
| 8Z68 | A | Orphan | Orphan | GPR68 | Homo sapiens | - | - | chim(NtGi1-Gs)/β1/γ2 | 2.64 | 2025-04-23 | To be published | |
| 8J18 | A | Orphan | Orphan | GPR84 | Homo sapiens | (3R)-3-Hydroxydodecanoic acid | - | Gi1/β1/γ2 | 2.89 | 2023-06-21 | doi.org/10.1038/s41467-023-38985-6 | |
| 8J19 | A | Orphan | Orphan | GPR84 | Homo sapiens | LY237 | - | Gi1/β1/γ2 | 3.23 | 2023-06-21 | doi.org/10.1038/s41467-023-38985-6 | |
| 8J1A | A | Orphan | Orphan | GPR84 | Homo sapiens | - | - | Gi1/β1/γ2 | 3.24 | 2023-06-21 | doi.org/10.1038/s41467-023-38985-6 | |
| 8G05 | A | Orphan | Orphan | GPR84 | Homo sapiens | 6-OAU | - | Gi1/β1/γ2 | 3 | 2023-11-01 | doi.org/10.1038/s41467-023-41201-0 | |
| 7WZ4 | A | Orphan | Orphan | GPR88 | Homo sapiens | - | - | Gi1/β1/γ2 | 3 | 2022-10-26 | doi.org/10.1038/s41467-022-30081-5 | |
| 9DQH | A | Orphan | Orphan | MRGPRD | Homo sapiens | EP-2825 | - | chim(NtGi1-Gs-CtGq)/β1/γ2 | 2.92 | 2024-12-11 | doi.org/10.1016/j.celrep.2024.114942 | |
| 9DQJ | A | Orphan | Orphan | MRGPRD | Homo sapiens | EP-3945 | - | chim(NtGi1-Gs-CtGq)/β1/γ2 | 2.9 | 2024-12-11 | doi.org/10.1016/j.celrep.2024.114942 | |
| 7Y12 | A | Orphan | Orphan | MRGPRD | Homo sapiens | β-Alanine | - | Gi1/β1/γ2 | 3.1 | 2022-07-20 | doi.org/10.1038/s42003-022-03668-3 | |
| 7Y15 | A | Orphan | Orphan | MRGPRD | Homo sapiens | - | - | Gi1/β1/γ2 | 2.9 | 2022-07-20 | doi.org/10.1038/s42003-022-03668-3 | |
| 8YFS | A | Orphan | Orphan | MRGPRE | Equus quagga | A1D6H | - | chim(NtGi1-Gs-CtGq)/β1/γ2 | 2.8 | 2025-03-05 | To be published | |
| 9UST | A | Orphan | Orphan | MRGPRE | Equus quagga | A1D6H | - | chim(NtGi1-Gs-CtGq)/β1/γ2 | 3.02 | 2025-07-02 | To be published | |
| 8JGB | A | Orphan | Orphan | MRGPRX1 | Homo sapiens | Conorfamide-Tx2 | - | Gi1/β1/γ2 | 2.84 | 2024-01-10 | doi.org/10.1038/s41467-023-40705-z | |
| 8JGF | A | Orphan | Orphan | MRGPRX1 | Homo sapiens | BAM8-22 | - | chim(NtGi1-Gs-CtGq)/β1/γ2 | 2.7 | 2024-01-10 | doi.org/10.1038/s41467-023-40705-z | |
| 8JGG | A | Orphan | Orphan | MRGPRX1 | Homo sapiens | BAM8-22 | - | Gi1/β1/γ2 | 3 | 2024-01-10 | doi.org/10.1038/s41467-023-40705-z | |
| 8DWC | A | Orphan | Orphan | MRGPRX1 | Homo sapiens | Proenkephalin-A | - | chim(NtGi2L-Gs-CtGq)/β1/γ2 | 2.87 | 2022-11-02 | doi.org/10.1038/s41589-022-01173-6 | |
| 8DWH | A | Orphan | Orphan | MRGPRX1 | Homo sapiens | PubChem 139030531 | - | chim(NtGi2L-Gs-CtGq)/β1/γ2 | 3.25 | 2022-11-02 | doi.org/10.1038/s41589-022-01173-6 | |
| 8HJ5 | A | Orphan | Orphan | MRGPRX1 | Homo sapiens | PubChem 139030531 | - | chim(NtGi1-Gs-CtGq)/β1/γ2 | 3 | 2023-05-31 | doi.org/10.1371/journal.pbio.3001975 | |
| 7VDH | A | Orphan | Orphan | MRGPRX2 | Homo sapiens | C48/80 | - | Gi1/β1/γ2 | 2.9 | 2021-12-01 | doi.org/10.1038/s41586-021-04077-y | |
| 7VDL | A | Orphan | Orphan | MRGPRX2 | Homo sapiens | Cortistatin-14 | - | Gi1/β1/γ2 | 3.22 | 2021-12-01 | doi.org/10.1038/s41586-021-04077-y | |
| 7VDM | A | Orphan | Orphan | MRGPRX2 | Homo sapiens | Substance-P | - | Gi1/β1/γ2 | 2.98 | 2021-12-01 | doi.org/10.1038/s41586-021-04077-y | |
| 7VUY | A | Orphan | Orphan | MRGPRX2 | Homo sapiens | - | - | Gi1/β1/γ2 | 2.84 | 2021-12-01 | doi.org/10.1038/s41586-021-04077-y | |
| 7VUZ | A | Orphan | Orphan | MRGPRX2 | Homo sapiens | - | - | Gi1/β1/γ2 | 2.89 | 2021-12-01 | doi.org/10.1038/s41586-021-04077-y | |
| 7VV3 | A | Orphan | Orphan | MRGPRX2 | Homo sapiens | - | - | Gi1/β1/γ2 | 2.97 | 2021-12-01 | doi.org/10.1038/s41586-021-04077-y | |
| 7VV5 | A | Orphan | Orphan | MRGPRX2 | Homo sapiens | C48/80 | - | Gi1/β1/γ2 | 2.76 | 2021-12-01 | doi.org/10.1038/s41586-021-04077-y | |
| 7S8L | A | Orphan | Orphan | MRGPRX2 | Homo sapiens | Cortistatin-14 | - | chim(NtGi2L-Gs-CtGq)/β1/γ2 | 2.45 | 2021-11-17 | doi.org/10.1038/s41586-021-04126-6 | |
| 7S8M | A | Orphan | Orphan | MRGPRX2 | Homo sapiens | Cortistatin-14 | - | Gi1/β1/γ2 | 2.54 | 2021-11-17 | doi.org/10.1038/s41586-021-04126-6 | |
| 7S8N | A | Orphan | Orphan | MRGPRX2 | Homo sapiens | R-Zinc-3573 | - | chim(NtGi2L-Gs-CtGq)/β1/γ2 | 2.9 | 2021-11-17 | doi.org/10.1038/s41586-021-04126-6 | |
| 7S8O | A | Orphan | Orphan | MRGPRX2 | Homo sapiens | R-Zinc-3573 | - | Gi1/β1/γ2 | 2.58 | 2021-11-17 | doi.org/10.1038/s41586-021-04126-6 | |
| 7S8P | A | Orphan | Orphan | MRGPRX4 | Homo sapiens | MS47134 | - | chim(NtGi2L-Gs-CtGq)/β1/γ2 | 2.6 | 2021-11-17 | doi.org/10.1038/s41586-021-04126-6 | |
| 8YRG | A | Orphan | Orphan | MRGPRX4 | Homo sapiens | Fospropofol | - | chim(NtGi1-Gs-CtGq)/β1/γ2 | 3.14 | 2024-05-22 | doi.org/10.1126/scitranslmed.adk8198 | |
| 8K4S | A | Orphan | Orphan | MRGPRX4 | Homo sapiens | DCA-3P | - | chim(NtGi1L-Gs-CtGq)/β1/γ2 | 2.9 | 2024-11-06 | doi.org/10.1016/j.cell.2024.10.001 | |
| 8ITF | A | Orphan | Orphan | TA9 | Mus musculus | DMCHA | - | chim(NtGi1-Gs)/β1/γ2 | 3.46 | 2023-05-31 | doi.org/10.1038/s41586-023-06106-4 | |
| 8IW1 | A | Orphan | Orphan | TA9 | Mus musculus | - | - | chim(NtGi1-Gs)/β1/γ2 | 3.4 | 2023-05-31 | doi.org/10.1038/s41586-023-06106-4 | |
| 8IW4 | A | Orphan | Orphan | TA9 | Mus musculus | Spermidine | - | chim(NtGi1-Gs)/β1/γ2 | 3.49 | 2023-05-31 | doi.org/10.1038/s41586-023-06106-4 | |
| 8IW7 | A | Orphan | Orphan | TA9 | Mus musculus | 2-Phenylethylamine | - | chim(NtGi1-Gs)/β1/γ2 | 2.97 | 2023-05-31 | doi.org/10.1038/s41586-023-06106-4 | |
| 8IW9 | A | Orphan | Orphan | TA9 | Mus musculus | - | - | chim(NtGi1-Gs)/β1/γ2 | 3.08 | 2023-05-31 | doi.org/10.1038/s41586-023-06106-4 | |
| 8YK0 | C | Orphan | Orphan | GPR156 | Homo sapiens | - | - | Gi3/β1/γ2 | 2.4 | 2025-02-05 | doi.org/10.1038/s41467-024-54681-5 | |
| 8IED | C | Orphan | Orphan | GPR156 | Homo sapiens | A1LYA | - | Go/β1/γ2 | 3.33 | 2024-02-14 | doi.org/10.1038/s41594-024-01224-7 | |
| 8YYX | A | Alicarboxylic acid | Oxoglutarate | Oxoglutarate | Homo sapiens | - | Leukotriene e4 | chim(Gi1-CtGq)/β1/γ2 | 2.84 | 2025-04-09 | To be published | |
| 8YYW | A | Alicarboxylic acid | Oxoglutarate | Oxoglutarate | Homo sapiens | α-ketoglutarate | α-ketoglutarate | chim(Gi1-CtGq)/β1/γ2 | 3.19 | 2025-04-09 | To be published | |
| 7XXH | A | Nucleotide | P2Y | P2Y1 | Homo sapiens | 2MeSADP | - | chim(NtGi1-G11)/β1/γ2 | 2.9 | 2023-06-07 | doi.org/10.1093/procel/pwac025 | |
| 8WJX | A | Nucleotide | P2Y | P2Y1 | Homo sapiens | ADP | - | chim(Gs-CtGq)/β1/γ2 | 3.2 | 2024-10-02 | To be published | |
| 8KGG | A | Nucleotide | P2Y | P2Y10 | Homo sapiens | LPS | - | chim(NtGi2-G13)/β1/γ2 | 3.06 | 2024-07-31 | doi.org/10.1016/j.chembiol.2024.08.005 | |
| 7XXI | A | Nucleotide | P2Y | P2Y12 | Homo sapiens | 2MeSADP | - | Gi2/β1/γ2 | 3 | 2023-06-07 | doi.org/10.1093/procel/pwac025 | |
| 9J0F | A | Nucleotide | P2Y | P2Y14 | Homo sapiens | NADH | - | Gi1/β1/γ2 | 2.76 | 2025-06-04 | doi.org/10.1038/s41421-025-00799-9 | |
| 9J0I | A | Nucleotide | P2Y | P2Y14 | Homo sapiens | UDP-Glucuronic acid | - | Gi1/β1/γ2 | 2.76 | 2025-06-04 | doi.org/10.1038/s41421-025-00799-9 | |
| 9K20 | A | Nucleotide | P2Y | P2Y2 | Homo sapiens | ATP | - | chim(NtGi1-Go)/β1/γ2 | 2.65 | 2025-06-11 | doi.org/10.1038/s41421-025-00797-x | |
| 9K0X | A | Nucleotide | P2Y | P2Y2 | Homo sapiens | ATP | - | chim(NtGi1-Gs-CtGq)/β1/γ2 | 2.83 | 2025-06-11 | doi.org/10.1038/s41421-025-00797-x | |
| 9K25 | A | Nucleotide | P2Y | P2Y2 | Homo sapiens | - | - | chim(NtGi1-Gs-CtGq)/β1/γ2 | 3.31 | 2025-06-11 | doi.org/10.1038/s41421-025-00797-x | |
| 9K0K | A | Nucleotide | P2Y | P2Y4 | Homo sapiens | UTP | - | chim(NtGi1-Gs-CtGq)/β1/γ2 | 3.14 | 2025-06-11 | doi.org/10.1038/s41421-025-00797-x | |
| 8WZ2 | A | Peptide | P518 | QRFP | Homo sapiens | Orexigenic Neuropeptide QRFP | - | chim(NtGi1L-Gs-CtGq)/β1/γ2 | 2.73 | 2024-06-19 | doi.org/10.1038/s41421-024-00670-3 | |
| 8ZH8 | A | Peptide | P518 | QRFP | Homo sapiens | QRF-Amide | - | Gq/β1/γ1 | 3.19 | 2024-07-03 | doi.org/10.1038/s41467-024-49030-5 | |
| 8GW8 | B1 | Peptide | Parathyroid Hormone | PTH1 | Homo sapiens | - | PCO371 | Gs/β1/γ2 | 2.9 | 2023-06-14 | doi.org/10.1038/s41586-023-06169-3 | |
| 8JR9 | B1 | Peptide | Parathyroid Hormone | PTH1 | Homo sapiens | - | PCO371 | chim(NtGi1-Gs)/β1/γ2 | 2.57 | 2023-08-02 | doi.org/10.1038/s41586-023-06467-w | |
| 7VVJ | B1 | Peptide | Parathyroid Hormone | PTH1 | Homo sapiens | PTHrP(1-36) | - | Gs/β1/γ2 | 3.2 | 2022-08-03 | doi.org/10.1016/j.molcel.2022.07.003 | |
| 7VVK | B1 | Peptide | Parathyroid Hormone | PTH1 | Homo sapiens | PTH | - | Gs/β1/γ2 | 3.3 | 2022-08-03 | doi.org/10.1016/j.molcel.2022.07.003 | |
| 7VVL | B1 | Peptide | Parathyroid Hormone | PTH1 | Homo sapiens | PTH | - | Gs/β1/γ2 | 2.8 | 2022-08-03 | doi.org/10.1016/j.molcel.2022.07.003 | |
| 7VVM | B1 | Peptide | Parathyroid Hormone | PTH1 | Homo sapiens | PTH | - | Gs/β1/γ2 | 3.2 | 2022-08-03 | doi.org/10.1016/j.molcel.2022.07.003 | |
| 7VVN | B1 | Peptide | Parathyroid Hormone | PTH1 | Homo sapiens | PTH | - | Gs/β1/γ2 | 3.8 | 2022-08-03 | doi.org/10.1016/j.molcel.2022.07.003 | |
| 7VVO | B1 | Peptide | Parathyroid Hormone | PTH1 | Homo sapiens | PTH | - | Gs/β1/γ2 | 4.1 | 2022-08-03 | doi.org/10.1016/j.molcel.2022.07.003 | |
| 8FLQ | B1 | Peptide | Parathyroid Hormone | PTH1 | Homo sapiens | PTH | - | Gs/β1/γ2 | 2.55 | 2023-04-26 | doi.org/10.1016/j.str.2023.04.002 | |
| 8FLR | B1 | Peptide | Parathyroid Hormone | PTH1 | Homo sapiens | PTHrP(1-36) | - | Gs/β1/γ2 | 2.94 | 2023-04-26 | doi.org/10.1016/j.str.2023.04.002 | |
| 8FLS | B1 | Peptide | Parathyroid Hormone | PTH1 | Homo sapiens | Abaloparatide | - | Gs/β1/γ2 | 3.09 | 2023-04-26 | doi.org/10.1016/j.str.2023.04.002 | |
| 8FLT | B1 | Peptide | Parathyroid Hormone | PTH1 | Homo sapiens | M-PTH(1-14) | - | Gs/β1/γ2 | 3.03 | 2023-04-26 | doi.org/10.1016/j.str.2023.04.002 | |
| 8FLU | B1 | Peptide | Parathyroid Hormone | PTH1 | Homo sapiens | Long-Acting PTH | - | Gs/β1/γ2 | 2.76 | 2023-04-26 | doi.org/10.1016/j.str.2023.04.002 | |
| 8HA0 | B1 | Peptide | Parathyroid Hormone | PTH1 | Homo sapiens | PTH | - | chim(NtGi1-Gs)/β1/γ2 | 2.62 | 2022-12-21 | doi.org/10.1038/s41401-022-01032-z | |
| 8HAF | B1 | Peptide | Parathyroid Hormone | PTH1 | Homo sapiens | PTHrP(1-36) | - | chim(NtGi1-Gs)/β1/γ2 | 3.25 | 2022-12-21 | doi.org/10.1038/s41401-022-01032-z | |
| 8HAO | B1 | Peptide | Parathyroid Hormone | PTH1 | Homo sapiens | PTH | - | chim(NtGi1-Gs)/β1/γ2 | 3.76 | 2022-12-21 | doi.org/10.1038/s41401-022-01032-z | |
| 6NBF | B1 | Peptide | Parathyroid Hormone | PTH1 | Homo sapiens | Long-Acting PTH Analog | - | Gs/β1/γ2 | 3 | 2019-04-17 | doi.org/10.1126/science.aav7942 | |
| 6NBH | B1 | Peptide | Parathyroid Hormone | PTH1 | Homo sapiens | Long-Acting PTH Analog | - | Gs/β1/γ2 | 3.5 | 2019-04-17 | doi.org/10.1126/science.aav7942 | |
| 6NBI | B1 | Peptide | Parathyroid Hormone | PTH1 | Homo sapiens | Long-Acting PTH Analog | - | Gs/β1/γ2 | 4 | 2019-04-17 | doi.org/10.1126/science.aav7942 | |
| 9B5Y | B1 | Peptide | Parathyroid Hormone | PTH1 | Homo sapiens | Long-Acting PTH | - | chim(NtGi1-Gq)/β1/γ2 | 3.49 | 2025-03-19 | doi.org/10.1073/pnas.2426178122 | |
| 7Y35 | B1 | Peptide | Parathyroid Hormone | PTH1 | Homo sapiens | Abaloparatide | - | Gs/β1/γ2 | 2.9 | 2023-07-05 | To be published | |
| 7Y36 | B1 | Peptide | Parathyroid Hormone | PTH1 | Homo sapiens | Teriparatide | - | Gs/β1/γ2 | 2.8 | 2023-07-05 | To be published | |
| 9JR2 | B1 | Peptide | Parathyroid Hormone | PTH1 | Homo sapiens | PTH | - | chim(NtGi1L-Gs-CtGq)/β1/γ2 | 2.8 | 2024-10-16 | To be published | |
| 9JR3 | B1 | Peptide | Parathyroid Hormone | PTH1 | Homo sapiens | PTH | - | chim(NtGi1L-Gs-CtGq)/β1/γ2 | 2.8 | 2024-10-16 | To be published | |
| 7F16 | B1 | Peptide | Parathyroid Hormone | PTH2 | Homo sapiens | TIP39 | - | Gs/β1/γ2 | 2.8 | 2021-08-18 | doi.org/10.1073/pnas.2101279118 | |
| 8XYD | A | Lipid | Platelet Activating Factor | PAF | Homo sapiens | Platelet Activating Factor | - | Gi1/β1/γ2 | 2.9 | 2024-11-13 | doi.org/10.1016/j.celrep.2024.114422 | |
| 8ZPS | A | Peptide | Prolactin-releasing peptide | PrRP | Homo sapiens | PrRP20 | - | chim(NtGi1-Gs-CtGq)/β1/γ2 | 2.97 | 2024-09-25 | doi.org/10.1038/s41421-024-00724-6 | |
| 8ZPT | A | Peptide | Prolactin-releasing peptide | PrRP | Homo sapiens | PrRP20 | - | chim(NtGi1-Gs-CtGq)/β1/γ2 | 2.96 | 2024-09-25 | doi.org/10.1038/s41421-024-00724-6 | |
| 9K26 | A | Peptide | Prolactin-releasing peptide | PrRP | Homo sapiens | PrRP31 | - | Gi1/β1/γ2 | 3 | 2025-01-29 | To be published | |
| 9K27 | A | Peptide | Prolactin-releasing peptide | PrRP | Homo sapiens | PrRP31 | - | chim(NtGi1-Gq)/β1/γ2 | 2.68 | 2025-01-29 | To be published | |
| 8ZVZ | A | Lipid | Prostaglandin | DP1 | Homo sapiens | BW245C | - | Gs/β1/γ2 | 2.35 | 2025-05-28 | doi.org/10.1073/pnas.2501902122 | |
| 8ZW0 | A | Lipid | Prostaglandin | DP1 | Homo sapiens | PGD2 | - | Gs/β1/γ2 | 2.72 | 2025-05-28 | doi.org/10.1073/pnas.2501902122 | |
| 9IYB | A | Lipid | Prostanoid | DP2 | Homo sapiens | Prostaglandin | A1D5Q | Gi1/β1/γ2 | 2.82 | 2024-12-04 | doi.org/10.1073/pnas.2403304121 | |
| 8XXU | A | Lipid | Prostanoid | DP2 | Homo sapiens | - | A1D5Q | Gi1/β1/γ2 | 2.54 | 2024-12-04 | doi.org/10.1073/pnas.2403304121 | |
| 8XXV | A | Lipid | Prostanoid | DP2 | Homo sapiens | Indomethacin | A1D5Q | Gi1/β1/γ2 | 2.33 | 2024-12-04 | doi.org/10.1073/pnas.2403304121 | |
| 9M1H | A | Lipid | Prostanoid | EP1 | Homo sapiens | Prostaglandin E2 | - | chim(NtGi1-Gs-CtGq)/β1/γ2 | 2.55 | 2025-04-09 | To be published | |
| 7CX2 | A | Lipid | Prostanoid | EP2 | Homo sapiens | PGE2 | - | Gs/β1/γ2 | 2.8 | 2021-05-05 | doi.org/10.1126/sciadv.abf1268 | |
| 7CX3 | A | Lipid | Prostanoid | EP2 | Homo sapiens | Taprenepag | - | Gs/β1/γ2 | 2.8 | 2021-05-05 | doi.org/10.1126/sciadv.abf1268 | |
| 7CX4 | A | Lipid | Prostanoid | EP2 | Homo sapiens | Evatanepag | - | Gs/β1/γ2 | 2.9 | 2021-05-05 | doi.org/10.1126/sciadv.abf1268 | |
| 7WU9 | A | Lipid | Prostanoid | EP3 | Homo sapiens | - | - | Gi1/β1/γ2 | 3.38 | 2022-08-17 | doi.org/10.1016/j.celrep.2022.111323 | |
| 8GDC | A | Lipid | Prostanoid | EP3 | Homo sapiens | PGE2 | - | Gi1/β1/γ2 | 3.5 | 2024-01-03 | doi.org/10.1073/pnas.2216329120 | |
| 7D7M | A | Lipid | Prostanoid | EP4 | Homo sapiens | Dinoprostone | - | Gs/β1/γ1 | 3.3 | 2020-11-18 | doi.org/10.1016/j.str.2020.11.007 | |
| 8GCM | A | Lipid | Prostanoid | EP4 | Homo sapiens | L902688 | - | Gi1/β1/γ2 | 3.5 | 2024-01-03 | doi.org/10.1073/pnas.2216329120 | |
| 8GCP | A | Lipid | Prostanoid | EP4 | Homo sapiens | PGE2 | - | Gi1/β1/γ2 | 3.1 | 2024-01-03 | doi.org/10.1073/pnas.2216329120 | |
| 8GD9 | A | Lipid | Prostanoid | EP4 | Homo sapiens | Rivenprost | - | Gs/β1/γ2 | 3.2 | 2024-01-03 | doi.org/10.1073/pnas.2216329120 | |
| 8GDA | A | Lipid | Prostanoid | EP4 | Homo sapiens | L902688 | - | Gs/β1/γ2 | 3.3 | 2024-01-03 | doi.org/10.1073/pnas.2216329120 | |
| 8GDB | A | Lipid | Prostanoid | EP4 | Homo sapiens | PGE2 | - | Gs/β1/γ2 | 3.1 | 2024-01-03 | doi.org/10.1073/pnas.2216329120 | |
| 8IUK | A | Lipid | Prostanoid | FP-alpha | Homo sapiens | PGF2-α | - | chim(NtGi1-Gs-CtGq)/β1/γ2 | 2.67 | 2023-07-12 | doi.org/10.1038/s41467-023-38411-x | |
| 8IUL | A | Lipid | Prostanoid | FP-alpha | Homo sapiens | Latanoprost | - | chim(NtGi1-Gs-CtGq)/β1/γ2 | 2.78 | 2023-07-12 | doi.org/10.1038/s41467-023-38411-x | |
| 8IUM | A | Lipid | Prostanoid | FP-alpha | Homo sapiens | Tafluprost acid | - | chim(NtGi1-Gs-CtGq)/β1/γ2 | 3.14 | 2023-07-12 | doi.org/10.1038/s41467-023-38411-x | |
| 8IQ4 | A | Lipid | Prostanoid | FP-alpha | Homo sapiens | Carboprost | - | chim(NtGi1-Gs-CtGq)/β1/γ2 | 2.7 | 2024-01-31 | doi.org/10.1038/s41467-023-43922-8 | |
| 8IQ6 | A | Lipid | Prostanoid | FP-alpha | Homo sapiens | Latanoprost | - | chim(NtGi1-Gs-CtGq)/β1/γ2 | 3.4 | 2024-01-31 | doi.org/10.1038/s41467-023-43922-8 | |
| 8XJK | A | Lipid | Prostanoid | FP-alpha | Homo sapiens | Cloprosetnol | - | chim(NtGi1-Gs-CtGq)/β1/γ2 | 2.63 | 2024-02-28 | doi.org/10.1016/j.celrep.2024.113893 | |
| 8XJL | A | Lipid | Prostanoid | FP-alpha | Homo sapiens | PGF2-α | - | chim(NtGi2-Gs-CtGq)/β1/γ2 | 2.77 | 2024-02-28 | doi.org/10.1016/j.celrep.2024.113893 | |
| 8XJM | A | Lipid | Prostanoid | FP-alpha | Homo sapiens | Latanoprost | - | chim(NtGi2-Gs-CtGq)/β1/γ2 | 2.85 | 2024-02-28 | doi.org/10.1016/j.celrep.2024.113893 | |
| 8X79 | A | Lipid | Prostanoid | I2 | Homo sapiens | MRE-269 | - | Gs/β1/γ2 | 2.41 | 2024-03-06 | doi.org/10.1126/sciadv.adk5184 | |
| 8X7A | A | Lipid | Prostanoid | I2 | Homo sapiens | Treprostinil | - | Gs/β1/γ2 | 2.56 | 2024-03-06 | doi.org/10.1126/sciadv.adk5184 | |
| 8XJN | A | Lipid | Prostanoid | TXA2 | Homo sapiens | Cloprosetnol | - | chim(NtGi1-Gs-CtGq)/β1/γ2 | 3.06 | 2024-02-28 | doi.org/10.1016/j.celrep.2024.113893 | |
| 8XJO | A | Lipid | Prostanoid | TXA2 | Homo sapiens | U46619 | - | chim(NtGi1-Gs-CtGq)/β1/γ2 | 3.11 | 2024-02-28 | doi.org/10.1016/j.celrep.2024.113893 | |
| 8XOR | A | Peptide | Proteinase Activated | PAR1 | Homo sapiens | - | - | chim(NtGi1-Gs-CtGq)/β1/γ2 | 3 | 2024-09-18 | doi.org/10.1038/s41422-024-00997-2 | |
| 8XOS | A | Peptide | Proteinase Activated | PAR1 | Homo sapiens | - | - | Gi1/β1/γ2 | 3.2 | 2024-09-18 | doi.org/10.1038/s41422-024-00997-2 | |
| 9D4Z | A | Peptide | Proteinase Activated | PAR1 | Homo sapiens | - | - | chim(NtGi1L-Gs-CtGq)/β1/γ2 | 2.74 | 2025-05-07 | doi.org/10.1038/s41467-025-59138-x | |
| 9D0A | A | Peptide | Proteinase Activated | PAR2 | Homo sapiens | - | - | chim(NtGi1L-Gs-CtGq)/β1/γ2 | 3.1 | 2025-05-07 | doi.org/10.1038/s41467-025-59138-x | |
| 9E7R | A | Peptide | Proteinase Activated | PAR2 | Homo sapiens | GB88 | - | chim(NtGi1L-Gs-CtGq)/β1/γ2 | 3.18 | 2025-05-07 | doi.org/10.1038/s41467-025-59138-x | |
| 8ZMD | A | Peptide | Proteinase Activated | PAR2 | Homo sapiens | - | - | chim(NtGi1L-Gs-CtGq)/β1/γ2 | 3.25 | 2025-05-28 | To be published | |
| 8ZME | A | Peptide | Proteinase Activated | PAR2 | Homo sapiens | - | - | chim(NtGi1-G13)/β1/γ2 | 3.2 | 2025-05-28 | To be published | |
| 7TMW | A | Peptide | Relaxin | RXFP1 | Homo sapiens | - | - | Gs/β1/γ2 | 3.2 | 2023-02-15 | doi.org/10.1101/2022.01.22.477343 | |
| 7YJ4 | A | Peptide | Relaxin | RXFP4 | Homo sapiens | INSL5 | - | Gi2/β1/γ2 | 3.19 | 2023-03-01 | doi.org/10.1038/s41467-023-36182-z | |
| 7YK6 | A | Peptide | Relaxin | RXFP4 | Homo sapiens | PubChem 138319674 | - | Gi2/β1/γ2 | 3.03 | 2023-03-01 | doi.org/10.1038/s41467-023-36182-z | |
| 7YK7 | A | Peptide | Relaxin | RXFP4 | Homo sapiens | DC591053 | - | Gi2/β1/γ2 | 2.75 | 2023-03-01 | doi.org/10.1038/s41467-023-36182-z | |
| 9IK8 | A | Peptide | Somatostatin | SST1 | Homo sapiens | SST analogue | - | Gi1/β1/γ2 | 2.82 | 2025-04-30 | doi.org/10.1016/j.apsb.2025.03.043 | |
| 9IK9 | A | Peptide | Somatostatin | SST1 | Homo sapiens | SST analogue | - | Gi1/β1/γ2 | 3.37 | 2025-04-30 | doi.org/10.1016/j.apsb.2025.03.043 | |
| 8XIO | A | Peptide | Somatostatin | SST1 | Homo sapiens | L797591 | - | chim(NtGi1-Gs-CtGi1)/β1/γ2 | 2.65 | 2024-07-03 | doi.org/10.1073/pnas.2400298121 | |
| 8XIP | A | Peptide | Somatostatin | SST1 | Homo sapiens | Pasireotide | - | chim(NtGi1-Gs-CtGi1)/β1/γ2 | 3.29 | 2024-07-03 | doi.org/10.1073/pnas.2400298121 | |
| 7XAT | A | Peptide | Somatostatin | SST2 | Homo sapiens | Somatostatin-14 | - | Gi1/β1/γ2 | 2.85 | 2022-08-31 | doi.org/10.1038/s41421-022-00405-2 | |
| 7XAU | A | Peptide | Somatostatin | SST2 | Homo sapiens | Octreotide | - | Gi1/β1/γ2 | 2.97 | 2022-08-31 | doi.org/10.1038/s41421-022-00405-2 | |
| 7XAV | A | Peptide | Somatostatin | SST2 | Homo sapiens | Lanreotide | - | Gi1/β1/γ2 | 2.87 | 2022-08-31 | doi.org/10.1038/s41421-022-00405-2 | |
| 7WIC | A | Peptide | Somatostatin | SST2 | Homo sapiens | Somatostatin-14 | - | Gi1/β1/γ2 | 2.8 | 2022-06-01 | doi.org/10.1038/s41422-022-00669-z | |
| 7WIG | A | Peptide | Somatostatin | SST2 | Homo sapiens | L-054,264 | - | Gi1/β1/γ2 | 2.7 | 2022-06-01 | doi.org/10.1038/s41422-022-00669-z | |
| 7XMR | A | Peptide | Somatostatin | SST2 | Homo sapiens | Somatostatin-14 | - | Gi1/β1/γ2 | 3.1 | 2022-08-03 | doi.org/10.1038/s41422-022-00679-x | |
| 7YAC | A | Peptide | Somatostatin | SST2 | Homo sapiens | Paltusotine | - | Gi1/β1/γ2 | 3.24 | 2023-04-19 | doi.org/10.1038/s41467-023-36673-z | |
| 7YAE | A | Peptide | Somatostatin | SST2 | Homo sapiens | Octreotide | - | Gi1/β1/γ2 | 3.37 | 2023-04-19 | doi.org/10.1038/s41467-023-36673-z | |
| 7Y24 | A | Peptide | Somatostatin | SST2 | Homo sapiens | Octreotide | - | Go/β1/γ2 | 3.25 | 2022-10-19 | doi.org/10.1038/s41589-022-01130-3 | |
| 7Y26 | A | Peptide | Somatostatin | SST2 | Homo sapiens | Octreotide | - | chim(NtGi2L-Gs-CtGq)/β1/γ2 | 3.3 | 2022-10-19 | doi.org/10.1038/s41589-022-01130-3 | |
| 7Y27 | A | Peptide | Somatostatin | SST2 | Homo sapiens | Somatostatin-14 | - | chim(NtGi2L-Gs-CtGq)/β1/γ2 | 3.48 | 2022-10-19 | doi.org/10.1038/s41589-022-01130-3 | |
| 7WJ5 | A | Peptide | Somatostatin | SST2 | Homo sapiens | Somatostatin-14 | - | Gi1/β1/γ2 | 3.72 | 2022-07-13 | doi.org/10.7554/eLife.76823 | |
| 7T10 | A | Peptide | Somatostatin | SST2 | Homo sapiens | Somatostatin-14 | - | Gi3/β1/γ2 | 2.5 | 2022-03-09 | doi.org/10.1038/s41594-022-00727-5 | |
| 7T11 | A | Peptide | Somatostatin | SST2 | Homo sapiens | Octreotide | - | Gi3/β1/γ2 | 2.7 | 2022-03-09 | doi.org/10.1038/s41594-022-00727-5 | |
| 8XIQ | A | Peptide | Somatostatin | SST3 | Homo sapiens | L796778 | - | chim(NtGi1-Gs-CtGi1)/β1/γ2 | 2.71 | 2024-07-03 | doi.org/10.1073/pnas.2400298121 | |
| 8XIR | A | Peptide | Somatostatin | SST3 | Homo sapiens | Pasireotide | - | chim(NtGi1-Gs-CtGi1)/β1/γ2 | 2.52 | 2024-07-03 | doi.org/10.1073/pnas.2400298121 | |
| 8ZBI | A | Peptide | Somatostatin | SST3 | Homo sapiens | Somatostatin-14 | - | Gi1/β1/γ2 | 2.79 | 2025-04-30 | To be published | |
| 7XMS | A | Peptide | Somatostatin | SST4 | Homo sapiens | Somatostatin-14 | - | Gi1/β1/γ2 | 2.9 | 2022-08-03 | doi.org/10.1038/s41422-022-00679-x | |
| 7XMT | A | Peptide | Somatostatin | SST4 | Homo sapiens | J-2156 | - | Gi1/β1/γ2 | 2.8 | 2022-08-03 | doi.org/10.1038/s41422-022-00679-x | |
| 8ZBE | A | Peptide | Somatostatin | SST5 | Homo sapiens | Octreotide | - | Gi1/β1/γ1 | 3.24 | 2024-07-10 | doi.org/10.1038/s41401-024-01314-8 | |
| 8ZCJ | A | Peptide | Somatostatin | SST5 | Homo sapiens | Pasireotide | - | Gi1/β1/γ1 | 3.09 | 2024-07-10 | doi.org/10.1038/s41401-024-01314-8 | |
| 8X8L | A | Peptide | Somatostatin | SST5 | Homo sapiens | Cortistatin | - | chim(NtGi1-Gs-CtGi1)/β1/γ2 | 2.7 | 2024-06-12 | doi.org/10.1073/pnas.2321710121 | |
| 8X8N | A | Peptide | Somatostatin | SST5 | Homo sapiens | Octreotide | - | chim(NtGi1-Gs-CtGi1)/β1/γ2 | 2.9 | 2024-06-12 | doi.org/10.1073/pnas.2321710121 | |
| 8ZBJ | A | Peptide | Somatostatin | SST5 | Homo sapiens | Somatostatin-14 | - | Gi1/β1/γ2 | 2.94 | 2025-04-30 | To be published | |
| 7AD3 | D1 | Ste2-like | STE2 | STE2 | Saccharomyces cerevisiae | α-factor mating pheromone | - | Gi1/STE4/γ2 | 3.3 | 2020-12-09 | doi.org/10.1038/s41586-020-2994-1 | |
| 8JPN | A | Alicarboxylic acid | Succinate | Succinate | Homo sapiens | Cis-Epoxysuccinic acid | - | Gi1/β1/γ1 | 2.9 | 2024-05-22 | doi.org/10.1038/s41422-024-00968-7 | |
| 8JPP | A | Alicarboxylic acid | Succinate | Succinate | Homo sapiens | Succinic acid | - | chim(Gs-CtGq)/β1/γ1 | 3.2 | 2024-05-22 | doi.org/10.1038/s41422-024-00968-7 | |
| 8YKW | A | Alicarboxylic acid | Succinate | Succinate | Homo sapiens | Succinic acid | - | Gi1/β1/γ1 | 2.75 | 2024-05-29 | doi.org/10.1038/s41422-024-00984-7 | |
| 8YKX | A | Alicarboxylic acid | Succinate | Succinate | Homo sapiens | Maleic acid | - | Gi1/β1/γ1 | 2.69 | 2024-05-29 | doi.org/10.1038/s41422-024-00984-7 | |
| 8WOG | A | Alicarboxylic acid | Succinate | Succinate | Homo sapiens | Succinic acid | - | Gi1/β1/γ2 | 2.97 | 2024-09-11 | doi.org/10.1016/j.celrep.2024.114381 | |
| 8WP1 | A | Alicarboxylic acid | Succinate | Succinate | Homo sapiens | Cis-Epoxysuccinic acid | - | Gi1/β1/γ2 | 3.15 | 2024-09-11 | doi.org/10.1016/j.celrep.2024.114381 | |
| 8YKV | A | Alicarboxylic acid | Succinate | Succinate | Homo sapiens | PubChem 137553168 | - | Gi1/β1/γ2 | 2.48 | 2024-05-29 | doi.org/10.1038/s41422-024-00984-7 | |
| 7RMG | A | Peptide | Tachykinin | NK1 | Homo sapiens | Substance-P | - | chim(Gs-CtGq)/β1/γ2 | 3 | 2021-11-03 | doi.org/10.1038/s41589-021-00890-8 | |
| 7RMH | A | Peptide | Tachykinin | NK1 | Homo sapiens | Substance-P | - | Gs/β1/γ2 | 3.1 | 2021-11-03 | doi.org/10.1038/s41589-021-00890-8 | |
| 7RMI | A | Peptide | Tachykinin | NK1 | Homo sapiens | Substance-P | - | chim(Gs-CtGq)/β1/γ2 | 3.2 | 2021-11-03 | doi.org/10.1038/s41589-021-00890-8 | |
| 8U26 | A | Peptide | Tachykinin | NK1 | Homo sapiens | Protachykinin-1 | - | Gs/β1/γ2 | 2.5 | 2023-11-15 | doi.org/10.1038/s41592-023-02082-9 | |
| 7P00 | A | Peptide | Tachykinin | NK1 | Homo sapiens | Substance-P | - | chim(NtGi1-Gs-CtGq)/β1/γ2 | 2.71 | 2021-12-15 | doi.org/10.1126/sciadv.abk2872 | |
| 7P02 | A | Peptide | Tachykinin | NK1 | Homo sapiens | Protachykinin-1 | - | chim(NtGi1-Gs)/β1/γ2 | 2.87 | 2021-12-15 | doi.org/10.1126/sciadv.abk2872 | |
| 7XWO | A | Peptide | Tachykinin | NK2 | Homo sapiens | Neurokinin-A | - | chim(NtGi1-Gs-CtGq)/β1/γ2 | 2.7 | 2023-05-31 | doi.org/10.1038/s41421-022-00437-8 | |
| 8JBF | A | Peptide | Tachykinin | NK3 | Homo sapiens | Senktide | - | chim(NtGi1-Gs-CtGq)/β1/γ2 | 3 | 2024-02-28 | doi.org/10.1038/s41421-023-00564-w | |
| 8JBG | A | Peptide | Tachykinin | NK3 | Homo sapiens | Neurokinin-B | - | chim(NtGi1-Gs-CtGq)/β1/γ2 | 2.8 | 2024-02-07 | doi.org/10.1038/s41421-023-00564-w | |
| 8JBH | A | Peptide | Tachykinin | NK3 | Homo sapiens | Substance-P | - | chim(NtGi1-Gs-CtGq)/β1/γ2 | 2.9 | 2024-02-07 | doi.org/10.1038/s41421-023-00564-w | |
| 9NOX | C | Sensory | Taste1 | TAS1R2 | Homo sapiens | - | - | chim(Gs-CtGt3)/β1/γ2 | 3 | 2025-04-09 | doi.org/10.1016/j.cell.2025.04.021 | |
| 9O38 | C | Sensory | Taste1 | TAS1R2; TAS1R3 | Homo sapiens | - | - | chim(Gs-CtGt3)/β1/γ2 | 3 | 2025-04-09 | doi.org/10.1016/j.cell.2025.04.021 | |
| 8RQL | T2 | Sensory | Taste2 | TAS2R14 | Homo sapiens | Flufenamic acid | Flufenamic acid | chim(NtGi1-Gt3)/β1/γ2 | 3.03 | 2024-11-27 | doi.org/10.1038/s41467-024-54157-6 | |
| 8XQR | T2 | Sensory | Taste2 | TAS2R14 | Homo sapiens | - | Flufenamic acid | Gt3/β1/γ1 | 3.2 | 2024-07-10 | doi.org/10.1038/s41586-024-07569-9 | |
| 8XQS | T2 | Sensory | Taste2 | TAS2R14 | Homo sapiens | Cholesterol | Flufenamic acid | Gi1/β1/γ1 | 3.3 | 2024-07-10 | doi.org/10.1038/s41586-024-07569-9 | |
| 8XQL | T2 | Sensory | Taste2 | TAS2R14 | Homo sapiens | Cholesterol | Aristolochic acid A | Gt3/β1/γ1 | 2.99 | 2024-07-10 | doi.org/10.1038/s41586-024-07569-9 | |
| 8XQN | T2 | Sensory | Taste2 | TAS2R14 | Homo sapiens | Cholesterol | Aristolochic acid A | Gi1/β1/γ1 | 3.05 | 2024-07-10 | doi.org/10.1038/s41586-024-07569-9 | |
| 8XQO | T2 | Sensory | Taste2 | TAS2R14 | Homo sapiens | Cholesterol | Aristolochic acid A | Gi1/β1/γ1 | 2.77 | 2024-07-10 | doi.org/10.1038/s41586-024-07569-9 | |
| 8XQP | T2 | Sensory | Taste2 | TAS2R14 | Homo sapiens | Cholesterol | Aristolochic acid A | Gt3/β1/γ1 | 3.29 | 2024-07-10 | doi.org/10.1038/s41586-024-07569-9 | |
| 8XQT | T2 | Sensory | Taste2 | TAS2R14 | Homo sapiens | Cholesterol | - | Gi1/β1/γ1 | 2.94 | 2024-07-10 | doi.org/10.1038/s41586-024-07569-9 | |
| 9K6L | T2 | Sensory | Taste2 | TAS2R16 | Homo sapiens | SA0 | - | Gi2/β1/γ2 | 2.77 | 2025-04-02 | To be published | |
| 9KPD | T2 | Sensory | Taste2 | TAS2R16 | Homo sapiens | SA0 | - | chim(Gs-CtGt3)/β1/γ2 | 2.84 | 2025-04-02 | To be published | |
| 9KPE | T2 | Sensory | Taste2 | TAS2R16 | Homo sapiens | SA0 | - | Gi1/β1/γ2 | 3.35 | 2025-04-02 | To be published | |
| 9KPF | T2 | Sensory | Taste2 | TAS2R16 | Homo sapiens | SA0 | - | Gi1/β1/γ2 | 3.15 | 2025-04-02 | To be published | |
| 7XP4 | T2 | Sensory | Taste2 | TAS2R46 | Homo sapiens | - | - | chim(Gs-CtGt3)/β1/γ2 | 3.01 | 2022-10-12 | doi.org/10.1126/science.abo1633 | |
| 7XP5 | T2 | Sensory | Taste2 | TAS2R46 | Homo sapiens | - | - | chim(Gs-CtGt3)/β1/γ2 | 3.08 | 2022-10-12 | doi.org/10.1126/science.abo1633 | |
| 7XP6 | T2 | Sensory | Taste2 | TAS2R46 | Homo sapiens | Strychnine | - | chim(Gs-CtGt3)/β1/γ2 | 3.01 | 2022-10-12 | doi.org/10.1126/science.abo1633 | |
| 7XW9 | A | Peptide | Thyrotropin Releasing Hormone | TRH | Homo sapiens | TRH | - | chim(NtGi1L-Gs-CtGq)/β1/γ2 | 2.7 | 2022-12-28 | doi.org/10.1038/s41421-022-00477-0 | |
| 7WKD | A | Peptide | Thyrotropin Releasing Hormone | TRH | Homo sapiens | TRH | - | chim(NtGi1-Gs-CtGq)/β1/γ2 | 3.01 | 2022-06-15 | doi.org/10.1038/s41422-022-00641-x | |
| 7X1T | A | Peptide | Thyrotropin Releasing Hormone | TRH | Homo sapiens | Taltirelin | - | chim(NtGi2L-Gs-CtGq)/β1/γ2 | 3.26 | 2022-08-31 | doi.org/10.1038/s41422-022-00646-6 | |
| 7X1U | A | Peptide | Thyrotropin Releasing Hormone | TRH | Homo sapiens | TRH | - | chim(NtGi2L-Gs-CtGq)/β1/γ2 | 3.19 | 2022-08-31 | doi.org/10.1038/s41422-022-00646-6 | |
| 8WC3 | A | Amine | Trace Amine Receptors | TA1 | Mus musculus | SEP-363856 | - | chim(NtGi1-Gs)/β1/γ2 | 3 | 2023-12-27 | doi.org/10.1016/j.cell.2023.10.014 | |
| 8WC4 | A | Amine | Trace Amine Receptors | TA1 | Mus musculus | ZH8651 | - | chim(NtGi1-Gs)/β1/γ2 | 3.1 | 2023-12-27 | doi.org/10.1016/j.cell.2023.10.014 | |
| 8WC5 | A | Amine | Trace Amine Receptors | TA1 | Mus musculus | Tetramethylammonium Ion | - | chim(NtGi1-Gs)/β1/γ2 | 3.3 | 2023-12-27 | doi.org/10.1016/j.cell.2023.10.014 | |
| 8WC6 | A | Amine | Trace Amine Receptors | TA1 | Mus musculus | 2-Phenylethylamine | - | chim(NtGi1-Gs)/β1/γ2 | 3.2 | 2023-12-27 | doi.org/10.1016/j.cell.2023.10.014 | |
| 8WC7 | A | Amine | Trace Amine Receptors | TA1 | Mus musculus | ZH8667 | - | chim(NtGi1-Gs)/β1/γ2 | 3.1 | 2023-12-27 | doi.org/10.1016/j.cell.2023.10.014 | |
| 8WC8 | A | Amine | Trace Amine Receptors | TA1 | Homo sapiens | ZH8651 | - | chim(NtGi1-Gs)/β1/γ2 | 2.9 | 2023-12-27 | doi.org/10.1016/j.cell.2023.10.014 | |
| 8WC9 | A | Amine | Trace Amine Receptors | TA1 | Mus musculus | ZH8651 | - | chim(NtGi1-Gs-CtGq)/β1/γ2 | 3.2 | 2023-12-27 | doi.org/10.1016/j.cell.2023.10.014 | |
| 8WCA | A | Amine | Trace Amine Receptors | TA1 | Homo sapiens | 2-Phenylethylamine | - | chim(NtGi1-Gs)/β1/γ2 | 3.48 | 2023-12-27 | doi.org/10.1016/j.cell.2023.10.014 | |
| 8WCB | A | Amine | Trace Amine Receptors | TA1 | Mus musculus | Cyclohexylammonium Ion | - | chim(NtGi1-Gs-CtGq)/β1/γ2 | 3.1 | 2023-12-27 | doi.org/10.1016/j.cell.2023.10.014 | |
| 8ZSJ | A | Amine | Trace Amine Receptors | TA1 | Homo sapiens | - | - | chim(NtGi1L-Gs-CtGq)/β1/γ2 | 2.8 | 2024-07-24 | doi.org/10.1016/j.celrep.2024.114505 | |
| 8ZSP | A | Amine | Trace Amine Receptors | TA1 | Homo sapiens | LSD | - | chim(NtGi1L-Gs-CtGq)/β1/γ2 | 3.14 | 2024-07-24 | doi.org/10.1016/j.celrep.2024.114505 | |
| 8ZSS | A | Amine | Trace Amine Receptors | TA1 | Homo sapiens | RO5263397 | - | chim(NtGi1-Gs)/β1/γ2 | 3.07 | 2024-07-24 | doi.org/10.1016/j.celrep.2024.114505 | |
| 8ZSV | A | Amine | Trace Amine Receptors | TA1 | Mus musculus | RO5263397 | - | chim(NtGi1-Gs)/β1/γ2 | 2.96 | 2024-07-24 | doi.org/10.1016/j.celrep.2024.114505 | |
| 8UHB | A | Amine | Trace Amine Receptors | TA1 | Homo sapiens | RO5256390 | - | Gs/β1/γ2 | 3.35 | 2024-01-10 | doi.org/10.1038/s41467-023-44601-4 | |
| 8W87 | A | Amine | Trace Amine Receptors | TA1 | Homo sapiens | METH | - | chim(NtGi1L-Gs)/β1/γ2 | 2.8 | 2023-11-22 | doi.org/10.1038/s41586-023-06775-1 | |
| 8W88 | A | Amine | Trace Amine Receptors | TA1 | Homo sapiens | SEP-363856 | - | Gs/β1/γ2 | 2.6 | 2023-11-22 | doi.org/10.1038/s41586-023-06775-1 | |
| 8W89 | A | Amine | Trace Amine Receptors | TA1 | Homo sapiens | PEA | - | chim(NtGi1L-Gs)/β1/γ2 | 3 | 2023-11-22 | doi.org/10.1038/s41586-023-06775-1 | |
| 8W8A | A | Amine | Trace Amine Receptors | TA1 | Homo sapiens | RO5256390 | - | chim(NtGi1L-Gs)/β1/γ2 | 2.8 | 2023-11-22 | doi.org/10.1038/s41586-023-06775-1 | |
| 8JLJ | A | Amine | Trace Amine Receptors | TA1 | Mus musculus | T1AM | - | chim(NtGi1-Gs)/β1/γ2 | 3.1 | 2023-11-15 | doi.org/10.1038/s41586-023-06804-z | |
| 8JLK | A | Amine | Trace Amine Receptors | TA1 | Mus musculus | Ulotaront | - | chim(NtGi1-Gs)/β1/γ2 | 3.22 | 2023-11-15 | doi.org/10.1038/s41586-023-06804-z | |
| 8JLN | A | Amine | Trace Amine Receptors | TA1 | Homo sapiens | T1AM | - | Gs/β1/γ2 | 3.24 | 2023-11-15 | doi.org/10.1038/s41586-023-06804-z | |
| 8JLO | A | Amine | Trace Amine Receptors | TA1 | Homo sapiens | Ulotaront | - | Gs/β1/γ2 | 3.52 | 2023-11-15 | doi.org/10.1038/s41586-023-06804-z | |
| 8JLP | A | Amine | Trace Amine Receptors | TA1 | Homo sapiens | Ralmitaront | - | Gs/β1/γ2 | 3.23 | 2023-11-15 | doi.org/10.1038/s41586-023-06804-z | |
| 8JLQ | A | Amine | Trace Amine Receptors | TA1 | Homo sapiens | Fenoldopam | - | Gs/β1/γ2 | 2.84 | 2023-11-15 | doi.org/10.1038/s41586-023-06804-z | |
| 8JLR | A | Amine | Trace Amine Receptors | TA1 | Homo sapiens | A77636 | - | chim(NtGi1-Gs)/β1/γ2 | 3 | 2023-11-15 | doi.org/10.1038/s41586-023-06804-z | |
| 8JSO | A | Amine | Trace Amine Receptors | TA1 | Homo sapiens | AMPH | - | chim(NtGi1-Gs)/β1/γ2 | 3.4 | 2023-11-15 | doi.org/10.1038/s41586-023-06804-z | |
| 9JKQ | A | Amine | Trace Amine Receptors | TA1 | Homo sapiens | METH | - | Gs/β1/γ2 | 2.66 | 2024-10-16 | doi.org/10.1021/acs.jmedchem.4c01961 | |
| 8PM2 | A | Amine | Trace Amine Receptors | TA7 | Mus musculus | DMCH | - | Gs/β1/γ2 | 2.92 | 2023-08-09 | doi.org/10.1101/2023.07.07.547762 | |
| 7RKY | A | Other | Unclassified | US27 | Human betaherpesvirus 5 | - | GDP | Gi1/β1/γ2 | 3.8 | 2022-01-26 | doi.org/10.1126/sciadv.abl5442 | |
| 7RKF | A | Other | Unclassified | US28 | Human betaherpesvirus 5 | Fractalkine | GDP | chim(NtGi1-G11)/β1/γ2 | 4 | 2022-01-26 | doi.org/10.1126/sciadv.abl5442 | |
| 7JHJ | A | Other | Unclassified | BILF1 | Human gammaherpesvirus 4 | - | - | Gi1/β1/γ2 | 3.2 | 2021-07-07 | doi.org/10.1016/j.immuni.2021.06.001 | |
| 8K4O | A | Other | Unclassified | KSHV | Human gammaherpesvirus 8 | CXCL1 | - | Gi1/β1/γ1 | 3.01 | 2024-07-24 | doi.org/10.1073/pnas.2403217121 | |
| 8K4P | A | Other | Unclassified | KSHV | Human gammaherpesvirus 8 | - | - | Gi1/β1/γ1 | 2.81 | 2024-07-24 | doi.org/10.1073/pnas.2403217121 | |
| 7RKX | A | Other | Unclassified | US27 | Human betaherpesvirus 5 | - | - | Gi1/β1/γ2 | 3.1 | 2022-01-26 | doi.org/10.1126/sciadv.abl5442 | |
| 7RKM | A | Other | Unclassified | US28 | Human betaherpesvirus 5 | Fractalkine | - | Gi1/β1/γ2 | 3.5 | 2022-01-26 | doi.org/10.1126/sciadv.abl5442 | |
| 7RKN | A | Other | Unclassified | US28 | Human betaherpesvirus 5 | Fractalkine | - | Gi1/β1/γ2 | 3.6 | 2022-01-26 | doi.org/10.1126/sciadv.abl5442 | |
| 7QVM | A | Peptide | Vasopressin and Oxytocin | OT | Homo sapiens | Oxytocin | - | chim(NtGi1-Go-CtGq)/β1/γ2 | 3.25 | 2022-08-10 | doi.org/10.1038/s41467-022-31325-0 | |
| 7RYC | A | Peptide | Vasopressin and Oxytocin | OT | Homo sapiens | Oxytocin | - | chim(NtGi2L-Gs-CtGq)/β1/γ2 | 2.9 | 2022-03-09 | doi.org/10.1038/s41594-022-00728-4 | |
| 7DW9 | A | Peptide | Vasopressin and Oxytocin | V2 | Homo sapiens | AVP | - | chim(NtGi1-Gs)/β1/γ2 | 2.6 | 2021-07-21 | doi.org/10.1038/s41422-021-00480-2 | |
| 7KH0 | A | Peptide | Vasopressin and Oxytocin | V2 | Homo sapiens | AVP | - | chim(NtGi1-Gs)/β1/γ2 | 2.8 | 2021-05-26 | doi.org/10.1038/s41422-021-00483-z | |
| 7BB6 | A | Peptide | Vasopressin and Oxytocin | V2 | Homo sapiens | AVP | - | Gs/β1/γ2 | 4.2 | 2021-06-02 | doi.org/10.1126/sciadv.abg5628 | |
| 7BB7 | A | Peptide | Vasopressin and Oxytocin | V2 | Homo sapiens | AVP | - | Gs/β1/γ2 | 4.4 | 2021-06-02 | doi.org/10.1126/sciadv.abg5628 | |
| 6P9Y | B1 | Peptide | VIP and PACAP | PAC1 | Homo sapiens | PACAP | - | Gs/β1/γ2 | 3.01 | 2020-02-05 | doi.org/10.1016/j.molcel.2020.01.012 | |
| 6M1H | B1 | Peptide | VIP and PACAP | PAC1 | Homo sapiens | Maxadilan | - | Gs/β1/γ2 | 3.6 | 2020-03-11 | doi.org/10.1038/s41422-020-0280-2 | |
| 6M1I | B1 | Peptide | VIP and PACAP | PAC1 | Homo sapiens | PACAP | - | Gs/β1/γ2 | 3.5 | 2020-03-11 | doi.org/10.1038/s41422-020-0280-2 | |
| 8E3X | B1 | Peptide | VIP and PACAP | PAC1 | Homo sapiens | PACAP27 | - | Gs/β1/γ2 | 2.3 | 2022-11-23 | doi.org/10.1038/s41467-022-34629-3 | |
| 6LPB | B1 | Peptide | VIP and PACAP | PAC1 | Homo sapiens | PACAP | - | Gs/β1/γ1 | 3.9 | 2020-03-11 | doi.org/10.1038/s41594-020-0386-8 | |
| 6VN7 | B1 | Peptide | VIP and PACAP | VPAC1 | Homo sapiens | PACAP | - | Gs/β1/γ2 | 3.2 | 2020-09-02 | doi.org/10.1038/s41467-020-17933-8 | |
| 8E3Y | B1 | Peptide | VIP and PACAP | VPAC1 | Homo sapiens | PACAP27 | - | Gs/β1/γ2 | 2.3 | 2022-11-23 | doi.org/10.1038/s41467-022-34629-3 | |
| 8E3Z | B1 | Peptide | VIP and PACAP | VPAC1 | Homo sapiens | VIP | - | Gs/β1/γ2 | 2.7 | 2022-11-23 | doi.org/10.1038/s41467-022-34629-3 | |
| 7VQX | B1 | Peptide | VIP and PACAP | VPAC1 | Homo sapiens | PACAP27 | - | Gs/β1/γ2 | 2.74 | 2022-05-18 | doi.org/10.1038/s41467-022-30041-z | |
| 7WBJ | B1 | Peptide | VIP and PACAP | VPAC1 | Homo sapiens | PACAP27 | - | Gs/β1/γ2 | 3.42 | 2022-05-18 | doi.org/10.1038/s41467-022-30041-z | |
| 9V0U | B2 | Adhesion | Adhesion | ADGRD1 | Homo sapiens | - | - | chim(NtGi1-G13)/β1/γ2 | 3.51 | 2025-07-30 | doi.org/10.1016/j.bbrc.2025.152165 | |
| 8YKD | B2 | Adhesion | Adhesion | ADGRG2 | Mus musculus | Dehydroepiandrosterone | - | chim(NtGi1-Gs)/β1/γ2 | 2.9 | 2025-08-13 | doi.org/10.1038/s41589-025-01896-2 | |
| 9IV6 | A | Orphan | Orphan | GPR4 | Homo sapiens | - | - | chim(NtGi1-Gs)/β1/γ2 | 2.71 | 2025-07-30 | To be published | |
| 9K3F | A | Peptide | Melanocortin | MC3 | Homo sapiens | - | - | chim(NtGi1-Gs)/β1/γ2 | 2.75 | 2025-08-06 | doi.org/10.1016/j.str.2025.03.004 | |
| 9K3H | A | Peptide | Melanocortin | MC5 | Homo sapiens | - | - | chim(NtGi1-Gs)/β1/γ2 | 2.86 | 2025-08-06 | doi.org/10.1016/j.str.2025.03.004 | |
| 9K3K | A | Peptide | Melanocortin | MC4 | Homo sapiens | - | - | chim(NtGi1-Gs)/β1/γ2 | 3.12 | 2025-08-06 | doi.org/10.1016/j.str.2025.03.004 | |
| 9K3L | A | Peptide | Melanocortin | MC2 | Homo sapiens | - | - | chim(NtGi1-Gs)/β1/γ2 | 3.01 | 2025-08-06 | doi.org/10.1016/j.str.2025.03.004 | |
| 9K3P | A | Peptide | Melanocortin | MC1 | Homo sapiens | - | - | chim(NtGi1-Gs)/β1/γ2 | 2.98 | 2025-08-06 | doi.org/10.1016/j.str.2025.03.004 | |
| 9EBI | A | Nucleotide | Adenosine | A3A | Homo sapiens | Piclidenoson | - | chim(NtGi1L-Gs-CtGi1)/β1/γ2 | 3.6 | 2025-08-20 | doi.org/10.1038/s41467-025-62872-x | |
| 9GG5 | A | Lipid | Prostanoid | TXA2 | Homo sapiens | U46619 | - | chim(NtGi2L-Gs-CtGq)/β1/γ2 | 3.26 | 2025-08-27 | To be published | |
| 9GGG | A | Lipid | Prostanoid | TXA2 | Homo sapiens | I-BOP | - | chim(NtGi2L-Gs-CtGq)/β1/γ2 | 3.25 | 2025-08-27 | To be published | |
| 9K07 | A | Peptide | Bombesin | BB3 | Homo sapiens | DSO-5a | - | chim(NtGi2L-Gs-CtGq)/β1/γ2 | 2.87 | 2025-08-27 | /doi.org/10.1016/j.apsb.2025.06.025 | |
| 9LWP | A | Peptide | Bombesin | BB3 | Homo sapiens | - | - | chim(NtGi2L-Gs-CtGq)/β1/γ2 | 2.93 | 2025-07-16 | doi.org/10.1016/j.apsb.2025.06.025 | |
| 8Y73 | A | Peptide | Opioid | μ | Homo sapiens | Peptide | MPAM-15 | Gi1/β1/γ2 | 2.84 | 2025-08-06 | To be published | |
| 9DYF | A | Amine | 5-Hydroxytryptamine | 5-HT1A | Homo sapiens | Asenapine | - | Gi1/β1/γ2 | 2.74 | 2025-08-13 | doi.org/10.1126/sciadv.adu9851 | |
| 9EBH | A | Nucleotide | Adenosine | A3A | Homo sapiens | Adenosine | - | Gi1/β1/γ2 | 3.6 | 2025-08-20 | doi.org/10.1038/s41467-025-62872-x | |
| 9M0R | A | Peptide | Neuropeptide FF | NPFF1 | Homo sapiens | Neuropeptide VF | - | Gi1/β1/γ2 | 2.47 | 2025-07-23 | doi.org/10.1016/j.celrep.2025.116160 | |
| 9M1O | A | Peptide | Neuropeptide FF | NPFF2 | Homo sapiens | Morphine-Modulating Neuropeptide B | - | Gi1/β1/γ2 | 2.49 | 2025-07-23 | doi.org/10.1016/j.celrep.2025.116160 | |
| 9M2F | A | Peptide | Neuropeptide FF | NPFF1 | Homo sapiens | Neuropeptide FF | - | Gi1/β1/γ2 | 2.93 | 2025-07-23 | doi.org/10.1016/j.celrep.2025.116160 | |
| 9M54 | A | Peptide | Neuropeptide FF | NPFF2 | Homo sapiens | Neuropeptide VF | - | Gi1/β1/γ2 | 3.24 | 2025-07-23 | doi.org/10.1016/j.celrep.2025.116160 | |
| 8Y72 | A | Peptide | Opioid | μ | Homo sapiens | Peptide | BMS-986122 | Gi1/β1/γ2 | 2.65 | 2025-08-06 | To be published | |
| 9KFI | A | Peptide | Relaxin | RXFP3 | Homo sapiens | Relaxin-3 | - | Gi2/β1/γ2 | 2.91 | 2025-08-13 | doi.org/10.1038/s42003-025-08220-7 | |
| 9KFJ | A | Peptide | Relaxin | RXFP3 | Homo sapiens | PubChem 138319674 | - | Gi2/β1/γ2 | 3.1 | 2025-08-13 | doi.org/10.1038/s42003-025-08220-7 | |
| 9KFK | A | Peptide | Relaxin | RXFP4 | Homo sapiens | Relaxin-3 | - | Gi2/β1/γ2 | 2.95 | 2025-08-13 | doi.org/10.1038/s42003-025-08220-7 | |
| 9DYD | A | Amine | 5-Hydroxytryptamine | 5-HT1A | Homo sapiens | Asenapine | - | Go/β1/γ2 | 2.96 | 2025-08-13 | doi.org/10.1126/sciadv.adu9851 | |
| 9DYE | A | Amine | 5-Hydroxytryptamine | 5-HT1A | Homo sapiens | Buspirone | - | Go/β1/γ2 | 2.9 | 2025-08-13 | doi.org/10.1126/sciadv.adu9851 | |
| 9PLO | A | Amine | Adrenegic | α2a | Homo sapiens | N-(5-methylnaphthalen-1-yl)pyridin-4-amine | - | Go/β1/γ2 | 2.74 | 2025-08-20 | To be published | |
| 8Z9O | A | Orphan | Orphan | GPR4 | Homo sapiens | - | - | Gs/β1/γ2 | 2.4 | 2025-07-16 | To be published | |
| 9AU0 | A | Lipid | Prostaglandin | DP1 | Homo sapiens | BW245C | - | Gs/β1/γ2 | 2.45 | 2025-08-27 | To be published | |
| 9I52 | A | Amine | Dopamine | D1 | Homo sapiens | A1IZU | - | Gs/β1/γ2 | 2.8 | 2025-07-16 | doi.org/10.1021/acs.jmedchem.5c00294 | |
| 9I54 | A | Amine | Dopamine | D1 | Homo sapiens | A1IZV | - | Gs/β1/γ2 | 2.72 | 2025-07-16 | doi.org/10.1021/acs.jmedchem.5c00294 | |
| 9IXJ | A | Amine | Histamine | H2 | Homo sapiens | Histamine | - | Gs/β1/γ2 | 2.92 | 2025-07-30 | To be published | |
| 9JFT | A | Orphan | Orphan | GPR65 | Homo sapiens | - | - | Gs/β1/γ2 | 3.27 | 2025-08-13 | doi.org/10.1038/s41422-025-01092-w |