psnGPCRdb

GProteins → Single PSN

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Show: Click this button to access the corresponding database entry page.

PDB: PDB code of the receptor used to compute the network and a direct link to the corresponding entry in the Protein Data Bank.

Class: Receptor Class.

SubFamily: Receptor Sub Family.

Type: Receptor Type.

Subtype: Receptor SubType.

Species: Organism.

Orthosteric Ligand: Name of the orthosteric ligand, if present.

Other Ligand(s): Name of other allosteric ligands, if present.

Protein Partners: G Protein, Arrestin or Kinase coupled to a given receptor.

Resolution: Structure resolution.

Date: Deposition date.

DOI: DOI and link of the corresponding paper.

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ShowPDBClassSubFamilyTypeSubTypeSpeciesOrthosteric LigandOther Ligand(s)Protein PartnersResolutionDateDOI
3DQBASensoryOpsinsRhodopsinBos taurus--Gt(CT)3.22008-09-23doi.org/10.1038/nature07330
3PQRASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal-Gt(CT)2.852011-03-09doi.org/10.1038/nature09789
2X72ASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal-Gt(CT)32011-03-16doi.org/10.1038/nature09795
3SN6AAmineAdrenergicβ2Homo sapiensBI167107-Gs/β1/γ23.22011-07-20doi.org/10.1038/nature10361
4A4MASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal-Gt(CT)3.32012-01-25doi.org/10.1073/pnas.1114089108
4BEYASensoryOpsinsRhodopsinBos taurus--Gt(CT)2.92013-05-08doi.org/10.1038/embor.2013.44
4J4QASensoryOpsinsRhodopsinBos taurusOctyl β-D-Glucopyranoside-Gt(CT)2.652013-10-30doi.org/10.1002/anie.201302374
4X1HASensoryOpsinsRhodopsinBos taurusNonyl-β-D-Glucopyranoside-Gt(CT)2.292015-11-04doi.org/10.1016/j.str.2015.09.015
5G53ANucleotideAdenosineA2AHomo sapiensNECA-Gs3.42016-08-03doi.org/10.1038/nature18966
5EN0ASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal-Gt(CT)2.812016-08-10doi.org/10.15252/embr.201642671
5UZ7B1PeptideCalcitoninCTHomo sapiens--Gs/β1/γ24.12017-05-03doi.org/10.1038/nature22327
5VAIB1PeptideGlucagonGLP-1Oryctolagus cuniculusGLP-1-Gs/β1/γ24.12017-05-24doi.org/10.1038/nature22394
5WKTASensoryOpsinsRhodopsinBos taurusOctyl-β-D-Glucopyranoside-Gt(CT)3.22017-12-13doi.org/10.1038/nprot.2017.135
6B3JB1PeptideGlucagonGLP-1Homo sapiensExendin-P5-Gs/β1/γ23.32018-02-21doi.org/10.1038/nature25773
6GDGANucleotideAdenosineA2AHomo sapiensNECA-Gs/β1/γ14.112018-05-16doi.org/10.7554/eLife.35946
6DDEAPeptideOpioidμMus musculusDAMGO-Gi1/β1/γ23.52018-06-13doi.org/10.1038/s41586-018-0219-7
6DDFAPeptideOpioidμMus musculusDAMGO-Gi1/β1/γ23.52018-06-13doi.org/10.1038/s41586-018-0219-7
6G79AAmine5-Hydroxytryptamine5-HT1BHomo sapiensDonitriptan-Go/β1/γ23.782018-06-20doi.org/10.1038/s41586-018-0241-9
6D9HANucleotideAdenosineA1Homo sapiensAdenosine-Gi2/β1/γ23.62018-06-20doi.org/10.1038/s41586-018-0236-6
6CMOASensoryOpsinsRhodopsinHomo sapiens--Gi1/β1/γ24.52018-06-20doi.org/10.1038/s41586-018-0215-y
6E3YB1PeptideCalcitoninCT LikeHomo sapiensCalcitonin gene-related peptide-1-Gs/β1/γ2; RAMP13.32018-09-19doi.org/10.1038/s41586-018-0535-y
6FUFASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal-Go3.122018-10-03doi.org/10.1126/sciadv.aat7052
6NIYB1PeptideCalcitoninCTHomo sapiensCalcitonin-1-Gs/β1/γ23.342019-01-23doi.org/10.1021/acsptsci.8b00056
6N4BALipidCannabinoidCB1Homo sapiensMDMB-Fubinaca-Gi1/β1/γ232019-01-30doi.org/10.1016/j.cell.2018.11.040
6NBFB1PeptideParathyroid HormonePTH1Homo sapiensLA-PTH Analog-Gs/β1/γ232019-04-17doi.org/10.1126/science.aav7942
6NBHB1PeptideParathyroid HormonePTH1Homo sapiensLA-PTH Analog-Gs/β1/γ23.52019-04-17doi.org/10.1126/science.aav7942
6NBIB1PeptideParathyroid HormonePTH1Homo sapiensLA-PTH Analog-Gs/β1/γ242019-04-17doi.org/10.1126/science.aav7942
6OIJAAmineAcetylcholine (muscarinic)M1Homo sapiensIperoxo-chim(NtGi1L-G11)/β1/γ23.32019-05-08doi.org/10.1126/science.aaw5188
6OIKAAmineAcetylcholine (muscarinic)M2Homo sapiensIperoxoLY2119620chim(NtGi1-Go)/β1/γ23.62019-05-08doi.org/10.1126/science.aaw5188
6E67AAmineAdrenergicβ2Homo sapiensBI167107-Gs(CT)3.72019-06-05doi.org/10.1016/j.cell.2019.04.021
6OT0FProteinFrizzledSMOHomo sapiens-25(S)-EpoxycholesterolGi1/β1/γ23.842019-06-12doi.org/10.1038/s41586-019-1286-0
6OS9APeptideNeurotensinNTS1Homo sapiensJMV449-Gi1/β1/γ232019-07-10doi.org/10.1038/s41586-019-1337-6
6OSAAPeptideNeurotensinNTS1Homo sapiensJMV449-Gi1/β1/γ232019-07-10doi.org/10.1038/s41586-019-1337-6
6QNOASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal-Gi1/β1/γ14.382019-07-10doi.org/10.7554/eLife.46041
6OY9ASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal-Gt/β1/γ13.92019-07-24doi.org/10.1016/j.molcel.2019.06.007
6OYAASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal-Gt/β1/γ13.32019-07-24doi.org/10.1016/j.molcel.2019.06.007
6NI3AAmineAdrenergicβ2Homo sapiensBI167107-Gs/β1/γ23.82019-11-20doi.org/10.1038/s41594-019-0330-y
6ORVB1PeptideGlucagonGLP-1Homo sapiens-TT-OAD2Gs/β1/γ232020-01-08doi.org/10.1038/s41586-019-1902-z
6P9XB1PeptideCorticotropin Releasing FactorCRF1Homo sapiensCorticoliberin-1-Gs/β1/γ22.912020-02-05doi.org/10.1016/j.molcel.2020.01.012
6P9YB1PeptideVIP and PACAPPAC1Homo sapiensPACAP27-Gs/β1/γ23.012020-02-05doi.org/10.1016/j.molcel.2020.01.012
6KPGALipidCannabinoidCB1Homo sapiensAM841-Gi1/β1/γ232020-02-12doi.org/10.1016/j.cell.2020.01.008
6KPFALipidCannabinoidCB2Homo sapiensAM12033-Gi1/β1/γ22.92020-02-12doi.org/10.1016/j.cell.2020.01.008
6PT0ALipidCannabinoidCB2Homo sapiensWIN 55212-2-Gi1/β1/γ23.22020-02-12doi.org/10.1016/j.cell.2020.01.007
6PB0B1PeptideCorticotropin Releasing FactorCRF1Homo sapiensUrocortin-chim(NtGi1-Gs)/β1/γ232020-02-12doi.org/10.1016/j.molcel.2020.01.013
6PB1B1PeptideCorticotropin Releasing FactorCRF2Homo sapiensUrocortin-chim(NtGi1-Gs)/β1/γ22.82020-02-12doi.org/10.1016/j.molcel.2020.01.013
6NWEASensoryOpsinsRhodopsinBos taurusOctyl-β-D-Glucopyranoside-Gt(CT)2.712020-02-12To be published
6OMMAPeptideFormylpeptideFPR2-ALXHomo sapiensWKYMVX-Gi1/β1/γ23.172020-02-26doi.org/10.1038/s41467-020-14728-9
6LI3AOrphanOrphanGPR52Homo sapiens--Gs/β1/γ23.322020-02-26doi.org/10.1038/s41586-020-2019-0
6LPBB1PeptideVIP and PACAPPAC1Homo sapiensPACAP27-Gs/β1/γ13.92020-03-11doi.org/10.1038/s41594-020-0386-8
6M1HB1PeptideVIP and PACAPPAC1Homo sapiensMaxadilan-Gs/β1/γ23.62020-03-11doi.org/10.1038/s41422-020-0280-2
6M1IB1PeptideVIP and PACAPPAC1Homo sapiensPACAP27-Gs/β1/γ23.52020-03-11doi.org/10.1038/s41422-020-0280-2
6UUNB1PeptideCalcitoninCT Like (AM1)Homo sapiensAdrenomedullin-Gs/β1/γ2; RAMP232020-03-25doi.org/10.1021/acsptsci.9b00080
6UUSB1PeptideCalcitoninCT Like (AM2)Homo sapiensAdrenomedullin-Gs/β1/γ2; RAMP32.42020-04-01doi.org/10.1021/acsptsci.9b00080
6UVAB1PeptideCalcitoninCT Like (AM2)Homo sapiensAdrenomedullin-2-Gs/β1/γ2; RAMP32.32020-04-01doi.org/10.1021/acsptsci.9b00080
6LMKB1PeptideGlucagonGlucagonHomo sapiensGlucagon-Gs/β1/γ23.72020-04-01doi.org/10.1126/science.aaz5346
6LMLB1PeptideGlucagonGlucagonHomo sapiensGlucagon-Gi1/β1/γ13.92020-04-01doi.org/10.1126/science.aaz5346
6K41AAmineAdrenergicα2bHomo sapiensDexmedetomidine-Go/β1/γ22.92020-04-15doi.org/10.1038/s41589-020-0492-2
6K42AAmineAdrenergicα2bHomo sapiensDexmedetomidine-Gi1/β1/γ24.12020-04-15doi.org/10.1038/s41589-020-0492-2
6WHCB1PeptideGlucagonGlucagonHomo sapiensGlu16 analog of GCG-Gs/β1/γ23.42020-05-27doi.org/10.1074/jbc.RA120.013793
6VMSAAmineDopamineD2Homo sapiensBromoergocryptine-Gi1/β1/γ23.82020-06-17doi.org/10.1038/s41586-020-2379-5
6WWZAProteinChemokineCCR6Homo sapiensCCL20-Go/β1/γ23.342020-06-24doi.org/10.1038/s41467-020-16820-6
6PELASensoryOpsinsRhodopsinBos taurus-CitronellolGt(CT)3.192020-06-24To be published
6PGSASensoryOpsinsRhodopsinBos taurus-GeraniolGt(CT)2.92020-07-01To be published
6PH7ASensoryOpsinsRhodopsinBos taurus-NerolGt(CT)2.92020-07-01To be published
6VCBB1PeptideGlucagonGLP-1Homo sapiensGLP-1LSN3160440Gs/β1/γ23.32020-07-22doi.org/10.1038/s41589-020-0589-7
7BZ2AAmineAdrenergicβ2Homo sapiensArformoterol-Gs/β1/γ23.822020-08-05doi.org/10.1038/s41421-020-0176-9
6WPWB1PeptideGlucagonGlucagonHomo sapiensZP3780-Gs/β1/γ23.12020-08-12doi.org/10.1126/science.aba3373
6WI9B1PeptideGlucagonSecretinHomo sapiensSecretin-Gs/β1/γ24.32020-08-12doi.org/10.1038/s41467-020-17791-4
6WZGB1PeptideGlucagonSecretinHomo sapiensSecretin-Gs/β1/γ22.32020-08-12doi.org/10.1038/s41467-020-17791-4
7C2EB1PeptideGlucagonGLP-1Homo sapiensPubChem 149050799-Gs/β1/γ24.22020-08-26doi.org/10.1038/s41422-020-0384-8
7JJOAAmineAdrenergicβ1Meleagris gallopavoIsoprenaline-Gs/β1/γ22.62020-09-02doi.org/10.1016/j.molcel.2020.08.001
6LFMAProteinChemokineCXCR2Homo sapiensCXCL8-Gi1/β1/γ23.52020-09-02doi.org/10.1038/s41586-020-2492-5
6LFOAProteinChemokineCXCR2Homo sapiensCXCL8-Gi1/β1/γ23.42020-09-02doi.org/10.1038/s41586-020-2492-5
7BW0ASteroidBile AcidGPBAHomo sapiens--chim(NtGi1-Gs)/β1/γ23.92020-09-02doi.org/10.1038/s41392-020-00262-z
6VN7B1PeptideVIP and PACAPVPAC1Homo sapiensPACAP27-Gs/β1/γ23.22020-09-02doi.org/10.1038/s41467-020-17933-8
6X18B1PeptideGlucagonGLP-1Homo sapiensGLP-1-Gs/β1/γ22.12020-09-09doi.org/10.1016/j.molcel.2020.09.020
6X19B1PeptideGlucagonGLP-1Homo sapiensCHU-128-Gs/β1/γ22.12020-09-09doi.org/10.1016/j.molcel.2020.09.020
6X1AB1PeptideGlucagonGLP-1Homo sapiensDanuglipron-Gs/β1/γ22.52020-09-09doi.org/10.1016/j.molcel.2020.09.020
7CFMASteroidBile AcidGPBAHomo sapiensP395-Gs/β1/γ232020-09-09doi.org/10.1038/s41586-020-2569-1
7CFNASteroidBile AcidGPBAHomo sapiensINT-777-Gs/β1/γ232020-09-09doi.org/10.1038/s41586-020-2569-1
6WHAAAmine5-Hydroxytryptamine5-HT2AHomo sapiensDB13948-chim(NtGi2L-Gs-CtGq)/β1/γ23.362020-09-23doi.org/10.1016/j.cell.2020.08.024
6XBJFProteinFrizzledSMOHomo sapiens-CholesterolGi1/β1/γ23.882020-09-30doi.org/10.1038/s41589-020-0646-2
6XBKFProteinFrizzledSMOHomo sapiens-CholesterolGi1/β1/γ23.242020-09-30doi.org/10.1038/s41589-020-0646-2
6XBLFProteinFrizzledSMOHomo sapiensSAGCholesterolGi1/β1/γ23.962020-09-30doi.org/10.1038/s41589-020-0646-2
6XBMFProteinFrizzledSMOHomo sapiens-25(S)-EpoxycholesterolGi1/β1/γ23.142020-09-30doi.org/10.1038/s41589-020-0646-2
7D3SB1PeptideGlucagonSecretinHomo sapiensSecretin-Gs/β1/γ22.92020-11-04doi.org/10.1016/j.bbrc.2020.08.042
7D7MALipidProstanoidEP4Homo sapiensPGE2-Gs/β1/γ13.32020-11-18doi.org/10.1016/j.str.2020.11.007
7CZ5B1PeptideGlucagonGHRHHomo sapiensSomatoliberin-Gs/β1/γ22.62020-11-18doi.org/10.1038/s41467-020-18945-0
6XOXB1PeptideGlucagonGLP-1Homo sapiensOrforglipron-chim(NtGi1-Gs)/β1/γ23.12020-11-18doi.org/10.1073/pnas.2014879117
7AD3D1Ste2-likeSTE2STE2; STE2Saccharomyces cerevisiaeα-factor mating pheromone-Gi1/STE4/γ23.32020-12-09doi.org/10.1038/s41586-020-2994-1
7DHIAAmineAdrenergicβ2Homo sapiensSalbutamol-Gs/β1/γ23.262020-12-16doi.org/10.1093/nsr/nwaa284
7DHRAAmineAdrenergicβ2Homo sapiensIsoprenaline-Gs/β1/γ23.82020-12-16doi.org/10.1093/nsr/nwaa284
7D68B1PeptideGlucagonGLP-2Homo sapiensGLP-2-Gs/β1/γ232020-12-16doi.org/10.1038/s41422-020-00442-0
7L0PAPeptideNeurotensinNTS1Rattus norvegicusNeurotensin-(8-13)-Gi1/β1/γ14.12021-01-06doi.org/10.1038/s41594-020-00554-6
7L0QAPeptideNeurotensinNTS1Rattus norvegicusNeurotensin-(8-13)-Gi1/β1/γ14.32021-01-06doi.org/10.1038/s41594-020-00554-6
7L0RAPeptideNeurotensinNTS1Rattus norvegicusNeurotensin-(8-13)-Gi1/β1/γ14.22021-01-06doi.org/10.1038/s41594-020-00554-6
7L0SAPeptideNeurotensinNTS1Rattus norvegicusNeurotensin-(8-13)-Gi1/β1/γ14.52021-01-06doi.org/10.1038/s41594-020-00554-6
7LCIB1PeptideGlucagonGLP-1Homo sapiensDanuglipron-Gs/β1/γ22.92021-01-20doi.org/10.1016/j.str.2021.04.008
7D76B2AdhesionAdhesionADGRG3Homo sapiensBeclomethasone-Go/β1/γ23.12021-02-03doi.org/10.1038/s41586-020-03083-w
7D77B2AdhesionAdhesionADGRG3Homo sapiensHydrocortisone-Go/β1/γ22.92021-02-03doi.org/10.1038/s41586-020-03083-w
7L1UAPeptideOrexinOX2Homo sapiensOrexin-chim(NtGi1-Gs-CtGq)/β1/γ23.22021-02-10doi.org/10.1038/s41467-021-21087-6
7L1VAPeptideOrexinOX2Homo sapiensPubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ232021-02-10doi.org/10.1038/s41467-021-21087-6
7JV5AAmineDopamineD1Homo sapiensSKF81297-Gs/β1/γ232021-02-24doi.org/10.1016/j.cell.2021.01.027
7JVPAAmineDopamineD1Homo sapiensSKF83959-Gs/β1/γ22.92021-02-24doi.org/10.1016/j.cell.2021.01.027
7JVQAAmineDopamineD1Homo sapiensApomorphine-Gs/β1/γ232021-02-24doi.org/10.1016/j.cell.2021.01.027
7JVRAAmineDopamineD2Homo sapiensBromoergocryptine-Gi1/β1/γ22.82021-02-24doi.org/10.1016/j.cell.2021.01.027
7CKWAAmineDopamineD1Homo sapiensFenoldopam-Gs/β1/γ23.222021-03-03doi.org/10.1016/j.cell.2021.01.028
7CKXAAmineDopamineD1Homo sapiensA77636-Gs/β1/γ23.542021-03-03doi.org/10.1016/j.cell.2021.01.028
7CKYAAmineDopamineD1Homo sapiensPW0464-Gs/β1/γ23.22021-03-03doi.org/10.1016/j.cell.2021.01.028
7CKZAAmineDopamineD1Homo sapiensDopamineMevidalenGs/β1/γ23.12021-03-03doi.org/10.1016/j.cell.2021.01.028
7CRHAAmineDopamineD1Homo sapiensSKF83959-Gs/β1/γ23.32021-03-03doi.org/10.1016/j.cell.2021.01.028
7LJCAAmineDopamineD1Homo sapiensSKF81297MevidalenGs/β1/γ232021-03-03doi.org/10.1038/s41422-021-00482-0
7LJDAAmineDopamineD1Homo sapiensDopamineMevidalenGs/β1/γ13.22021-03-03doi.org/10.1038/s41422-021-00482-0
7CMUAAmineDopamineD3Homo sapiensPramipexole-Gi1/β1/γ232021-03-10doi.org/10.1016/j.molcel.2021.01.003
7CMVAAmineDopamineD3Homo sapiensPD128907-Gi1/β1/γ22.72021-03-10doi.org/10.1016/j.molcel.2021.01.003
7DFLAAmineHistamineH1Homo sapiensHistamine-chim(NtGi1L-Gq)/β1/γ23.32021-03-31doi.org/10.1038/s41467-021-22427-2
7E2XAAmine5-Hydroxytryptamine5-HT1AHomo sapiens-PtdIns4PGi1/β1/γ232021-04-14doi.org/10.1038/s41586-021-03376-8
7E2YAAmine5-Hydroxytryptamine5-HT1AHomo sapiensSerotoninPtdIns4PGi1/β1/γ232021-04-14doi.org/10.1038/s41586-021-03376-8
7E2ZAAmine5-Hydroxytryptamine5-HT1AHomo sapiensAripiprazolePtdIns4PGi1/β1/γ23.12021-04-14doi.org/10.1038/s41586-021-03376-8
7E33AAmine5-Hydroxytryptamine5-HT1EHomo sapiensBRL-54443-Gi1/β1/γ22.92021-04-14doi.org/10.1038/s41586-021-03376-8
7JOZAAmineDopamineD1Homo sapiensPubChem 75202022-Gs/β1/γ23.82021-04-14doi.org/10.1038/s41467-021-23519-9
7E32AAmine5-Hydroxytryptamine5-HT1DHomo sapiensSerotonin-Gi1/β1/γ22.92021-04-21doi.org/10.1038/s41586-021-03376-8
7AUEAPeptideMelanocortinMC4Homo sapiensSetmelanotide-chim(NtGi1L-Gs)/β1/γ22.972021-04-28doi.org/10.1126/science.abf7958
7CX2ALipidProstanoidEP2Homo sapiensPGE2-Gs/β1/γ22.82021-05-05doi.org/10.1126/sciadv.abf1268
7CX3ALipidProstanoidEP2Homo sapiensTaprenepag-Gs/β1/γ22.82021-05-05doi.org/10.1126/sciadv.abf1268
7CX4ALipidProstanoidEP2Homo sapiensEvatanepag-Gs/β1/γ22.92021-05-05doi.org/10.1126/sciadv.abf1268
7EB2CAminoacidGABABGABAB2; GABAB1Homo sapiensBaclofenrac-BHFFGi1/β1/γ23.52021-05-05doi.org/10.1038/s41586-021-03507-1
7MBXAPeptideCholecystokininCCKAHomo sapiensCholecystokinin-8-Gs/β1/γ11.952021-05-26doi.org/10.1371/journal.pbio.3001295
7MBYAPeptideCholecystokininCCKAHomo sapiensCholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ22.442021-05-26doi.org/10.1371/journal.pbio.3001295
7KH0APeptideVasopressin and OxytocinV2Homo sapiensAVP-chim(NtGi1-Gs)/β1/γ22.82021-05-26doi.org/10.1038/s41422-021-00483-z
7BB6APeptideVasopressin and OxytocinV2Homo sapiensAVP-Gs/β1/γ24.22021-06-02doi.org/10.1126/sciadv.abg5628
7BB7APeptideVasopressin and OxytocinV2Homo sapiensAVP-Gs/β1/γ24.42021-06-02doi.org/10.1126/sciadv.abg5628
7E9GCAminoacidMetabotropic GlutamatemGlu2; mGlu2Homo sapiensEglumetadJNJ-40411813Gi1/β1/γ23.52021-06-23doi.org/10.1038/s41586-021-03495-2
7E9HCAminoacidMetabotropic GlutamatemGlu4; mGlu4Homo sapiensPhosphoserine-Gi3/β1/γ242021-06-23doi.org/10.1038/s41586-021-03495-2
7O7FAProteinChemokineCCR5Homo sapiens6P4-CCL5-Gi1/β1/γ13.152021-06-30doi.org/10.1126/sciadv.abg8685
7JHJAOtherUnclassifiedBILF1Human gammaherpesvirus 4--Gi1/β1/γ23.22021-07-07doi.org/10.1016/j.immuni.2021.06.001
7E14B1PeptideGlucagonGLP-1Homo sapiensOrforglipronPubChem 156022738Gs/β1/γ22.92021-07-07doi.org/10.1038/s41467-021-24058-z
7MTSCAminoacidMetabotropic GlutamatemGlu2; mGlu2Homo sapiensGlutamateADX55164Gi1/β1/γ23.22021-07-07doi.org/10.1038/s41586-021-03680-3
7F1QAProteinChemokineCCR5Homo sapiensCCL3-Gi1/β1/γ22.92021-07-14doi.org/10.1038/s41467-021-24438-5
7F1RAProteinChemokineCCR5Homo sapiens--Gi1/β1/γ232021-07-14doi.org/10.1038/s41467-021-24438-5
7F1SAProteinChemokineCCR5Homo sapiens--Gi1/β1/γ22.82021-07-14doi.org/10.1038/s41467-021-24438-5
7DUQB1PeptideGlucagonGLP-1Homo sapiensGLP-1PubChem 156022738Gs/β1/γ22.52021-07-14doi.org/10.1038/s41467-021-24058-z
7DW9APeptideVasopressin and OxytocinV2Homo sapiensAVP-chim(NtGi1-Gs)/β1/γ22.62021-07-21doi.org/10.1038/s41422-021-00480-2
7EXDAAmine5-Hydroxytryptamine5-HT1FHomo sapiensLasmiditan-Gi1/β1/γ23.42021-08-04doi.org/10.1038/s41422-021-00527-4
7DH5AAmineAdrenergicβ3Canis lupus familiarisMirabegron-Gs/β1/γ23.162021-08-04doi.org/10.1016/j.molcel.2021.06.024
7DTYB1PeptideGlucagonGIPHomo sapiensGIP-Gs/β1/γ22.982021-08-04doi.org/10.7554/eLife.68719
7KI0B1PeptideGlucagonGLP-1Homo sapiensSemaglutide-Gs/β1/γ22.52021-08-04doi.org/10.1016/j.celrep.2021.109374
7KI1B1PeptideGlucagonGLP-1Homo sapiensTaspoglutide-Gs/β1/γ22.52021-08-04doi.org/10.1016/j.celrep.2021.109374
7DURB1PeptideGlucagonGLP-1Homo sapiens-PubChem 156022738Gs/β1/γ23.32021-08-11doi.org/10.1038/s41467-021-24058-z
7EVMB1PeptideGlucagonGLP-1Homo sapiens-PubChem 156022738Gs/β1/γ22.52021-08-11doi.org/10.1038/s41467-021-24058-z
7F9YAPeptideGhrelinGhrelinHomo sapiensGhrelin-chim(NtGi1-Gs-CtGq)/β1/γ22.92021-08-18doi.org/10.1038/s41467-021-25364-2
7F9ZAPeptideGhrelinGhrelinHomo sapiensGHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ23.22021-08-18doi.org/10.1038/s41467-021-25364-2
7DB6AMelatoninMelatoninMT1Homo sapiensRamelteon-Gi1/β1/γ23.32021-08-18doi.org/10.1038/s41594-021-00634-1
7F16B1PeptideParathyroid HormonePTH2Homo sapiensTIP39-Gs/β1/γ22.82021-08-18doi.org/10.1073/pnas.2101279118
7EZHAPeptideCholecystokininCCKAHomo sapiensCholecystokinin-8-Gi1/β1/γ23.22021-08-25doi.org/10.1038/s41589-021-00841-3
7EZKAPeptideCholecystokininCCKAHomo sapiensCholecystokinin-8-chim(NtGi1-Gs)/β1/γ23.12021-08-25doi.org/10.1038/s41589-021-00841-3
7EZMAPeptideCholecystokininCCKAHomo sapiensCholecystokinin-8-chim(NtGsL-Gq)/β1/γ22.92021-08-25doi.org/10.1038/s41589-021-00841-3
7LD3ANucleotideAdenosineA1Homo sapiensAdenosineMIPS521Gi2/β1/γ23.22021-09-08doi.org/10.1038/s41586-021-03897-2
7LD4ANucleotideAdenosineA1Homo sapiensAdenosine-Gi2/β1/γ23.32021-09-08doi.org/10.1038/s41586-021-03897-2
7F4DAPeptideMelanocortinMC1Homo sapiensα-MSH-chim(NtGi1-Gs)/β1/γ232021-09-08doi.org/10.1038/s41422-021-00557-y
7F4FAPeptideMelanocortinMC1Homo sapiensAfamelanotide-chim(NtGi1-Gs)/β1/γ22.92021-09-08doi.org/10.1038/s41422-021-00557-y
7F4HAPeptideMelanocortinMC1Homo sapiensAfamelanotide-chim(NtGi1-Gs)/β1/γ22.72021-09-08doi.org/10.1038/s41422-021-00557-y
7F4IAPeptideMelanocortinMC1Homo sapiensSHU9119-chim(NtGi1-Gs)/β1/γ23.12021-09-08doi.org/10.1038/s41422-021-00557-y
7FIGAProteinGlycoprotein HormoneLHHomo sapienshCG-chim(NtGi1L-Gs)/β1/γ23.92021-09-29doi.org/10.1038/s41586-021-03924-2
7FIHAProteinGlycoprotein HormoneLHHomo sapienshCGOrg43553chim(NtGi1-Gs)/β1/γ23.22021-09-29doi.org/10.1038/s41586-021-03924-2
7FIIAProteinGlycoprotein HormoneLHHomo sapienshCG-chim(NtGi1-Gs)/β1/γ24.32021-09-29doi.org/10.1038/s41586-021-03924-2
7EVYALipidLysophospholipidS1P1Homo sapiensSiponimod-Gi1/β1/γ22.982021-09-29doi.org/10.1038/s41422-021-00566-x
7EVZALipidLysophospholipidS1P1Homo sapiensCenerimod-Gi1/β1/γ23.072021-09-29doi.org/10.1038/s41422-021-00566-x
7EW0ALipidLysophospholipidS1P1Homo sapiensOzanimod-Gi1/β1/γ23.422021-09-29doi.org/10.1038/s41422-021-00566-x
7EW7ALipidLysophospholipidS1P1Homo sapiensSEW2871-Gi1/β1/γ23.272021-09-29doi.org/10.1038/s41422-021-00566-x
7EW2ALipidLysophospholipidS1P3Homo sapiensFTY720-P-Gi1/β1/γ23.12021-09-29doi.org/10.1038/s41422-021-00567-w
7EW3ALipidLysophospholipidS1P3Homo sapiensS1P-Gi1/β1/γ23.12021-09-29doi.org/10.1038/s41422-021-00567-w
7EW4ALipidLysophospholipidS1P3Homo sapiensCYM-5541-Gi1/β1/γ23.22021-09-29doi.org/10.1038/s41422-021-00567-w
7EW1ALipidLysophospholipidS1P5Homo sapiensSiponimod-Gi1/β1/γ23.42021-09-29doi.org/10.1038/s41422-021-00566-x
7RTBB1PeptideGlucagonGLP-1Homo sapiensPeptide-19-Gs/β1/γ22.142021-10-06doi.org/10.1016/j.bbrc.2021.09.016
7EIBAPeptideBradykininBK1Homo sapiensKallidin-des-Arg10-chim(NtGi1-Gs-CtGq)/β1/γ232021-10-13doi.org/10.1038/s41594-021-00645-y
7F2OAPeptideBradykininBK2Homo sapiensBradykinin-chim(NtGi1-Gs-CtGq)/β1/γ22.92021-10-13doi.org/10.1038/s41594-021-00645-y
7F8VAPeptideCholecystokininCCKBHomo sapiensGastrin-17-Gi2/β1/γ23.32021-10-13doi.org/10.1038/s41589-021-00866-8
7F8WAPeptideCholecystokininCCKBHomo sapiensGastrin-17-chim(NtGsL-Gq)/β1/γ23.12021-10-13doi.org/10.1038/s41589-021-00866-8
7V9MB1PeptideGlucagonGHRH (SV1)Homo sapiensSomatoliberin-Gs/β1/γ23.292021-10-20doi.org/10.1073/pnas.2106606118
7F53APeptideMelanocortinMC4Homo sapiensα-MSH-Gs/β1/γ232021-11-03doi.org/10.1038/s41422-021-00552-3
7F54APeptideMelanocortinMC4Homo sapiensAfamelanotide-Gs/β1/γ232021-11-03doi.org/10.1038/s41422-021-00552-3
7F55APeptideMelanocortinMC4Homo sapiensBremelanotide-Gs/β1/γ23.12021-11-03doi.org/10.1038/s41422-021-00552-3
7F58APeptideMelanocortinMC4Homo sapiensTHIQ-Gs/β1/γ23.12021-11-03doi.org/10.1038/s41422-021-00552-3
7RMGAPeptideTachykininNK1Homo sapiensSubstance-P-chim(Gs-CtGq)/β1/γ232021-11-03doi.org/10.1038/s41589-021-00890-8
7RMHAPeptideTachykininNK1Homo sapiensSubstance-P-Gs/β1/γ23.12021-11-03doi.org/10.1038/s41589-021-00890-8
7RMIAPeptideTachykininNK1Homo sapiensSubstance-P-chim(Gs-CtGq)/β1/γ23.22021-11-03doi.org/10.1038/s41589-021-00890-8
7S0FAAmineAdrenergicβ1Meleagris gallopavoIsoprenaline-Gi1/β1/γ22.962021-11-17doi.org/10.1038/s41594-021-00679-2
7S0GAAmineAdrenergicβ1Meleagris gallopavoIsoprenaline-chim(Gi1-CtGs)/β1/γ23.862021-11-17doi.org/10.1038/s41594-021-00679-2
7PIUAPeptideMelanocortinMC4Homo sapiensSetmelanotide-Gs/β1/γ22.582021-11-17doi.org/10.1038/s41422-021-00569-8
7PIVAPeptideMelanocortinMC4Homo sapiensAfamelanotide-Gs/β1/γ22.862021-11-17doi.org/10.1038/s41422-021-00569-8
7S8LAOrphanOrphanMRGPRX2Homo sapiensCortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ22.452021-11-17doi.org/10.1038/s41586-021-04126-6
7S8MAOrphanOrphanMRGPRX2Homo sapiensCortistatin-14-Gi1/β1/γ22.542021-11-17doi.org/10.1038/s41586-021-04126-6
7S8NAOrphanOrphanMRGPRX2Homo sapiensR-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ22.92021-11-17doi.org/10.1038/s41586-021-04126-6
7S8OAOrphanOrphanMRGPRX2Homo sapiensR-Zinc-3573-Gi1/β1/γ22.582021-11-17doi.org/10.1038/s41586-021-04126-6
7S8PAOrphanOrphanMRGPRX4Homo sapiensMS47134-chim(NtGi2L-Gs-CtGq)/β1/γ22.62021-11-17doi.org/10.1038/s41586-021-04126-6
7VDHAOrphanOrphanMRGPRX2Homo sapiensC48/80-Gi1/β1/γ22.92021-12-01doi.org/10.1038/s41586-021-04077-y
7VDLAOrphanOrphanMRGPRX2Homo sapiensCortistatin-14-Gi1/β1/γ23.222021-12-01doi.org/10.1038/s41586-021-04077-y
7VDMAOrphanOrphanMRGPRX2Homo sapiensSubstance-P-Gi1/β1/γ22.982021-12-01doi.org/10.1038/s41586-021-04077-y
7VUYAOrphanOrphanMRGPRX2Homo sapiens--Gi1/β1/γ22.842021-12-01doi.org/10.1038/s41586-021-04077-y
7VUZAOrphanOrphanMRGPRX2Homo sapiens--Gi1/β1/γ22.892021-12-01doi.org/10.1038/s41586-021-04077-y
7VV3AOrphanOrphanMRGPRX2Homo sapiens--Gi1/β1/γ22.972021-12-01doi.org/10.1038/s41586-021-04077-y
7VV5AOrphanOrphanMRGPRX2Homo sapiensC48/80-Gi1/β1/γ22.762021-12-01doi.org/10.1038/s41586-021-04077-y
7NA7APeptideGhrelinGhrelinHomo sapiensGhrelin-Gi1/β1/γ22.72021-12-15doi.org/10.1038/s41467-021-26735-5
7NA8APeptideGhrelinGhrelinHomo sapiensIbutamoren-Gi1/β1/γ22.72021-12-15doi.org/10.1038/s41467-021-26735-5
7P00APeptideTachykininNK1Homo sapiensSubstance-P-chim(NtGi1-Gs-CtGq)/β1/γ22.712021-12-15doi.org/10.1126/sciadv.abk2872
7P02APeptideTachykininNK1Homo sapiensSubstance-P-chim(NtGi1-Gs)/β1/γ22.872021-12-15doi.org/10.1126/sciadv.abk2872
7VUGAOrphanOrphanGPR139Homo sapiensJNJ-63533054-Gi1/β1/γ23.22021-12-29doi.org/10.1038/s41422-021-00591-w
7VUHAOrphanOrphanGPR139Homo sapiensJNJ-63533054-chim(Gs-CtGq)/β1/γ23.222021-12-29doi.org/10.1038/s41422-021-00591-w
7VUIAOrphanOrphanGPR139Homo sapiensJNJ-63533054GTPchim(Gs-CtGq)/β1/γ23.32021-12-29doi.org/10.1038/s41422-021-00591-w
7VUJAOrphanOrphanGPR139Homo sapiensJNJ-63533054GDPchim(Gs-CtGq)/β1/γ23.82021-12-29doi.org/10.1038/s41422-021-00591-w
7F6HAPeptideBradykininBK2Homo sapiensBradykinin-Gq/β1/γ22.92022-01-05doi.org/10.1038/s41467-022-28399-1
7F6IAPeptideBradykininBK2Homo sapiensKallidin-Gq/β1/γ22.82022-01-05doi.org/10.1038/s41467-022-28399-1
7S1MB1PeptideGlucagonGLP-1Homo sapiensExendin-4-D-Ala-Gs/β1/γ22.412022-01-05doi.org/10.1038/s41589-021-00945-w
7S3IB1PeptideGlucagonGLP-1Homo sapiens--Gs/β1/γ22.512022-01-05doi.org/10.1038/s41589-021-00945-w
7EO2ALipidLysophospholipidS1P1Homo sapiensFTY720-P-Gi1/β1/γ22.892022-01-05doi.org/10.1038/s41589-021-00930-3
7EO4ALipidLysophospholipidS1P1Homo sapiensSiponimod-Gi1/β1/γ22.862022-01-05doi.org/10.1038/s41589-021-00930-3
7WF7ALipidLysophospholipidS1P1Homo sapiensS1P-Gi1/β1/γ23.42022-01-05doi.org/10.1038/s41589-021-00930-3
7LLLB1PeptideGlucagonGLP-1Homo sapiensExendin-4-Gs/β1/γ23.72022-01-12doi.org/10.1038/s41467-021-27760-0
7LLYB1PeptideGlucagonGLP-1Homo sapiensOxyntomodulin-Gs/β1/γ23.32022-01-12doi.org/10.1038/s41467-021-27760-0
7W2ZAPeptideGhrelinGhrelinHomo sapiensGhrelin-Go/β1/γ22.82022-01-19doi.org/10.1038/s41467-022-27975-9
7RKXAOtherUnclassifiedUS27Human betaherpesvirus 5--Gi1/β1/γ23.12022-01-26doi.org/10.1126/sciadv.abl5442
7RKFAOtherUnclassifiedUS28Human betaherpesvirus 5CX3CL1GDPchim(NtGi1-G11)/β1/γ242022-01-26doi.org/10.1126/sciadv.abl5442
7RKMAOtherUnclassifiedUS28Human betaherpesvirus 5CX3CL1-Gi1/β1/γ23.52022-01-26doi.org/10.1126/sciadv.abl5442
7RKNAOtherUnclassifiedUS28Human betaherpesvirus 5CX3CL1-Gi1/β1/γ23.62022-01-26doi.org/10.1126/sciadv.abl5442
7TD0ALipidLysophospholipidLPA1Homo sapiensLPA-Gi1/β1/γ22.832022-02-09doi.org/10.1038/s41467-022-28417-2
7TD1ALipidLysophospholipidLPA1Homo sapiensLPA-Gi1/β1/γ23.082022-02-09doi.org/10.1038/s41467-022-28417-2
7TD2ALipidLysophospholipidLPA1Homo sapiensLPA-Gi1/β1/γ23.112022-02-09doi.org/10.1038/s41467-022-28417-2
7TD3ALipidLysophospholipidS1P1Homo sapiensS1P-Gi1/β1/γ232022-02-09doi.org/10.1038/s41467-022-28417-2
7TD4ALipidLysophospholipidS1P1Homo sapiensSiponimod-Gi1/β1/γ22.62022-02-09doi.org/10.1038/s41467-022-28417-2
7FINB1PeptideGlucagonGIPHomo sapiensPeptide-20; GGL-Gs/β1/γ23.12022-02-23doi.org/10.1038/s41467-022-28683-0
7VGXAPeptideNeuropeptide YY1Homo sapiensNeuropeptide-Y-Gi1/β1/γ23.22022-02-23doi.org/10.1038/s41467-022-28510-6
7FIYB1PeptideGlucagonGIPHomo sapiensTirzepatide-Gs/β1/γ23.42022-03-02doi.org/10.1038/s41467-022-28683-0
7VABB1PeptideGlucagonGIPHomo sapiensTirzepatide (non-acylated)-chim(NtGi1-Gs)/β1/γ23.22022-03-02doi.org/10.1038/s41467-022-28683-0
7FIMB1PeptideGlucagonGLP-1Homo sapiensTirzepatide-Gs/β1/γ23.42022-03-02doi.org/10.1038/s41467-022-28683-0
7VBIB1PeptideGlucagonGLP-1Homo sapiensTirzepatide (non-acylated)-Gs/β1/γ232022-03-02doi.org/10.1038/s41467-022-28683-0
7V35B1PeptideGlucagonGlucagonHomo sapiensPeptide-20-Gs/β1/γ23.52022-03-02doi.org/10.1038/s41467-022-28683-0
7VGYAMelatoninMelatoninMT1Homo sapiens2-Iodomelatonin-Gi1/β1/γ23.12022-03-02doi.org/10.1038/s41467-022-28111-3
7VGZAMelatoninMelatoninMT1Homo sapiensRamelteon-Gi1/β1/γ23.32022-03-02doi.org/10.1038/s41467-022-28111-3
7VH0AMelatoninMelatoninMT2Homo sapiensRamelteon-Gi1/β1/γ13.462022-03-02doi.org/10.1038/s41467-022-28111-3
7VKTALipidLeukotrieneBLT1Homo sapiensLTB4-Gi1/β1/γ22.92022-03-09doi.org/10.1038/s41467-022-28820-9
7RYCAPeptideVasopressin and OxytocinOTHomo sapiensOxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ22.92022-03-09doi.org/10.1038/s41594-022-00728-4
7VL8AProteinChemokineCCR1Homo sapiens--Gi1/β1/γ22.92022-03-23doi.org/10.1038/s41589-021-00918-z
7VL9AProteinChemokineCCR1Homo sapiensCCL15(26-92)-Gi1/β1/γ22.62022-03-23doi.org/10.1038/s41589-021-00918-z
7VLAAProteinChemokineCCR1Homo sapiensCCL15(27-92)-Gi1/β1/γ22.72022-03-23doi.org/10.1038/s41589-021-00918-z
7TYLB1PeptideCalcitoninCTHomo sapiensAmylin-Gs/β1/γ23.32022-03-23doi.org/10.1126/science.abm9609
7TYOB1PeptideCalcitoninCTHomo sapiensCalcitonin-Gs/β1/γ22.72022-03-23doi.org/10.1126/science.abm9609
7TYFB1PeptideCalcitoninCT (AMY1)Homo sapiensAmylin-Gs/β1/γ2; RAMP12.22022-03-23doi.org/10.1126/science.abm9609
7TYWB1PeptideCalcitoninCT (AMY1)Homo sapiensCalcitonin-1-Gs/β1/γ2; RAMP132022-03-23doi.org/10.1126/science.abm9609
7TYHB1PeptideCalcitoninCT (AMY2)Homo sapiensCalcitonin-Gs/β1/γ2; RAMP23.32022-03-23doi.org/10.1126/science.abm9609
7TYYB1PeptideCalcitoninCT (AMY2)Homo sapiensCalcitonin-1-Gs/β1/γ2; RAMP232022-03-23doi.org/10.1126/science.abm9609
7TZFB1PeptideCalcitoninCT (AMY3)Homo sapiensAmylin-Gs/β1/γ2; RAMP32.42022-03-23doi.org/10.1126/science.abm9609
7TYIB1PeptideCalcitoninCTHomo sapiensAmylin-Gs/β1/γ23.32022-03-30doi.org/10.1126/science.abm9609
7TYNB1PeptideCalcitoninCTHomo sapiensCalcitonin-1-Gs/β1/γ22.62022-03-30doi.org/10.1126/science.abm9609
7TYXB1PeptideCalcitoninCT (AMY2)Homo sapiensAmylin-Gs/β1/γ2; RAMP22.552022-03-30doi.org/10.1126/science.abm9609
7T6TAPeptideFormylpeptideFPR1-ALXHomo sapiensfMLFII-Gi1/β1/γ23.22022-03-30doi.org/10.1038/s41467-022-28586-0
7T6SAPeptideFormylpeptideFPR2-ALXHomo sapiensTC-FPR 43-Gi1/β1/γ232022-03-30doi.org/10.1038/s41467-022-28586-0
7T6UAPeptideFormylpeptideFPR2-ALXHomo sapiensCGEN-855A-Gi1/β1/γ22.92022-03-30doi.org/10.1038/s41467-022-28586-0
7T6VAPeptideFormylpeptideFPR2-ALXHomo sapiensfMLFII-Gi1/β1/γ23.12022-03-30doi.org/10.1038/s41467-022-28586-0
7V9LB1PeptideGlucagonGHRH (SV1)Homo sapiens--chim(NtGi1-Gs)/β1/γ22.62022-04-06doi.org/10.1073/pnas.2106606118
7VBHB1PeptideGlucagonGLP-1Homo sapiensPeptide-20-Gs/β1/γ232022-04-06doi.org/10.1038/s41467-022-28683-0
7T6BALipidLysophospholipidS1P2Homo sapiensS1P-chim(NtGi1L-G13)/β1/γ23.192022-04-06doi.org/10.1126/sciadv.abn0067
7EJ0AAmineAdrenergicα2aHomo sapiensNorepinephrine-Go/β1/γ23.22022-04-13doi.org/10.1126/sciadv.abj5347
7EJ8AAmineAdrenergicα2aHomo sapiensBrimonidine-Go/β1/γ232022-04-13doi.org/10.1126/sciadv.abj5347
7EJAAAmineAdrenergicα2aHomo sapiensDexmedetomidine-Go/β1/γ23.62022-04-13doi.org/10.1126/sciadv.abj5347
7EJKAAmineAdrenergicα2aHomo sapiensOxymetazoline-Go/β1/γ23.42022-04-13doi.org/10.1126/sciadv.abj5347
7WVUAPeptideFormylpeptideFPR1-ALXHomo sapiensfMLF-Gi1/β1/γ23.32022-04-13doi.org/10.1038/s41467-022-29361-x
7WVVAPeptideFormylpeptideFPR2-ALXHomo sapiensfMLFII-Gi2/β1/γ22.92022-04-13doi.org/10.1038/s41467-022-29361-x
7WVWAPeptideFormylpeptideFPR2-ALXHomo sapiensfMYFINILTL-Gi2/β1/γ23.12022-04-13doi.org/10.1038/s41467-022-29361-x
7WVXAPeptideFormylpeptideFPR2-ALXHomo sapiensHumanin-Gi2/β1/γ22.82022-04-13doi.org/10.1038/s41467-022-29361-x
7WVYAPeptideFormylpeptideFPR2-ALXHomo sapiensAmyloid-β42-Gi2/β1/γ232022-04-13doi.org/10.1038/s41467-022-29361-x
7RA3B1PeptideGlucagonGIPHomo sapiensGIP-chim(NtGi1-Gs)/β1/γ23.242022-04-13doi.org/10.1073/pnas.2116506119
7RBTB1PeptideGlucagonGIPHomo sapiensTirzepatideLSN3556672chim(NtGi1-Gs)/β1/γ23.082022-04-13doi.org/10.1073/pnas.2116506119
7RG9B1PeptideGlucagonGLP-1Homo sapiens--chim(NtGi1-Gs)/β1/γ23.22022-04-13doi.org/10.1073/pnas.2116506119
7RGPB1PeptideGlucagonGLP-1Homo sapiensTirzepatide-chim(NtGi1-Gs)/β1/γ22.92022-04-13doi.org/10.1073/pnas.2116506119
7TUZAOrphanOrphanGPR183Homo sapiens7-α,25-dihydroxycholesterol-Gi1/β1/γ23.122022-04-13doi.org/10.1016/j.str.2022.04.006
7EJXAOrphanOrphanGPR88Homo sapiens-(1R;2R)-2-PCCAGi1/β1/γ22.42022-04-13doi.org/10.1038/s41467-022-30081-5
7WQ3APeptideGalaninGAL1Homo sapiensGalanin-Gi1/β1/γ22.72022-04-20doi.org/10.1038/s41467-022-29072-3
7WQ4APeptideGalaninGAL2Homo sapiensGalanin-chim(NtGi1-Gs-CtGq)/β1/γ22.62022-04-20doi.org/10.1038/s41467-022-29072-3
7SBFAPeptideOpioidμMus musculusPZM21-Gi1/β1/γ22.92022-04-20doi.org/10.1002/anie.202200269
7SCGAPeptideOpioidμMus musculusFH210-Gi1/β1/γ232022-04-20doi.org/10.1002/anie.202200269
7W53APeptideNeuromedin UNMUR1Homo sapiensNeuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ23.22022-04-20doi.org/10.1038/s41467-022-29683-w
7W56APeptideNeuromedin UNMUR1Homo sapiensNeuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ22.92022-04-20doi.org/10.1038/s41467-022-29683-w
7W55APeptideNeuromedin UNMUR2Homo sapiensNeuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ22.82022-04-20doi.org/10.1038/s41467-022-29683-w
7W57APeptideNeuromedin UNMUR2Homo sapiensNeuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ23.22022-04-20doi.org/10.1038/s41467-022-29683-w
7WU2B2AdhesionAdhesionADGRD1Homo sapiens--Gs/β1/γ12.82022-04-27doi.org/10.1038/s41586-022-04580-w
7WU3B2AdhesionAdhesionADGRF1Homo sapiens-K6GGs/β1/γ23.12022-04-27doi.org/10.1038/s41586-022-04580-w
7WU4B2AdhesionAdhesionADGRF1Homo sapiens-K6GGi1/β1/γ23.42022-04-27doi.org/10.1038/s41586-022-04580-w
7WU5B2AdhesionAdhesionADGRF1Homo sapiens-K6GGi1/β1/γ232022-04-27doi.org/10.1038/s41586-022-04580-w
7SF8B2AdhesionAdhesionADGRG1Homo sapiens--chim(NtGi2-G13)/β1/γ22.72022-04-27doi.org/10.1038/s41586-022-04575-7
7WUIB2AdhesionAdhesionADGRG2Mus musculusIP15-chim(NtGi1-Gs)/β1/γ23.12022-04-27doi.org/10.1038/s41586-022-04590-8
7WUQB2AdhesionAdhesionADGRG2Mus musculus--Gs/β1/γ22.92022-04-27doi.org/10.1038/s41586-022-04590-8
7WUJB2AdhesionAdhesionADGRG4Homo sapiens--chim(NtGi1-Gs)/β1/γ23.32022-04-27doi.org/10.1038/s41586-022-04590-8
7SF7B2AdhesionAdhesionADGRL3Homo sapiens--chim(NtGi2-G13)/β1/γ22.92022-04-27doi.org/10.1038/s41586-022-04575-7
7XJHAAmineAdrenergicβ3Canis lupus familiarisIsoprenaline-Gs/β1/γ23.32022-05-04doi.org/10.1016/j.molcel.2021.06.024
7XJIAAmineAdrenergicβ3Canis lupus familiarisSolabegron-Gs/β1/γ23.92022-05-04doi.org/10.1016/j.bbrc.2022.04.065
7U2LAPeptideOpioidμMus musculusC5-guano-Gi1/β1/γ23.22022-05-04doi.org/10.1038/s41586-022-05588-y
7EPTB2AdhesionAdhesionADGRD1Homo sapiens--Gs/β1/γ232022-05-11doi.org/10.1038/s41586-022-04619-y
7EQ1B2AdhesionAdhesionADGRG5Homo sapiens--chim(NtGi1-Gs)/β1/γ23.32022-05-11doi.org/10.1038/s41586-022-04619-y
7V68AAmineAcetylcholine (muscarinic)M4Homo sapiensIperoxoLY2119620Gi1/β1/γ23.42022-05-11doi.org/10.1038/s41467-022-30595-y
7V69AAmineAcetylcholine (muscarinic)M4Homo sapiens--Gi1/β1/γ23.42022-05-11doi.org/10.1038/s41467-022-30595-y
7V6AAAmineAcetylcholine (muscarinic)M4Homo sapiens-PubChem 9864275Gi1/β1/γ23.62022-05-11doi.org/10.1038/s41467-022-30595-y
7VQXB1PeptideVIP and PACAPVPAC1Homo sapiensPACAP27-Gs/β1/γ22.742022-05-18doi.org/10.1038/s41467-022-30041-z
7WBJB1PeptideVIP and PACAPVPAC1Homo sapiensPACAP27-Gs/β1/γ23.422022-05-18doi.org/10.1038/s41467-022-30041-z
7X9AAPeptideNeuropeptide YY1Homo sapiensNeuropeptide-Y-Gi1/β1/γ23.22022-05-18doi.org/10.1126/sciadv.abm1232
7X9BAPeptideNeuropeptide YY2Homo sapiensNeuropeptide-Y-Gi1/β1/γ23.42022-05-18doi.org/10.1126/sciadv.abm1232
7X9CAPeptideNeuropeptide YY4Homo sapiensPancreatic Hormone-Gi1/β1/γ232022-05-18doi.org/10.1126/sciadv.abm1232
7EUOAPeptideFormylpeptideFPR1-ALXHomo sapiensfMLF-Gi1/β1/γ22.92022-05-25doi.org/10.1038/s41467-022-32822-y
7SQOAPeptideOrexinOX2Homo sapiensTAK-925-Gi1/β1/γ23.172022-05-25doi.org/10.1038/s41467-022-30601-3
7WICAPeptideSomatostatinSST2Homo sapiensSomatostatin-14-Gi1/β1/γ22.82022-06-01doi.org/10.1038/s41422-022-00669-z
7WIGAPeptideSomatostatinSST2Homo sapiensL-054264-Gi1/β1/γ22.72022-06-01doi.org/10.1038/s41422-022-00669-z
7SR8APeptideOrexinOX2Homo sapiensTAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ23.32022-06-08doi.org/10.1038/s41467-022-30601-3
7WV9ALipidCannabinoidCB1Homo sapiensCP55940ZCZ011Gi2/β1/γ23.362022-06-15doi.org/10.1038/s41589-022-01038-y
7F0TAAmineDopamineD1Homo sapiensDopamine-Gs/β1/γ23.12022-06-15doi.org/10.1126/sciadv.abo4158
7F1OAAmineDopamineD1Homo sapiensDopamineGDP; MgGs/β1/γ23.132022-06-15doi.org/10.1126/sciadv.abo4158
7F1ZAAmineDopamineD1Homo sapiensDopamineGDPGs/β1/γ23.462022-06-15doi.org/10.1126/sciadv.abo4158
7F23AAmineDopamineD1Homo sapiensDopamineGDPGs/β1/γ23.582022-06-15doi.org/10.1126/sciadv.abo4158
7F24AAmineDopamineD1Homo sapiensDopamineGDPGs/β1/γ24.162022-06-15doi.org/10.1126/sciadv.abo4158
7X2DAAmineDopamineD1Homo sapiensTavapadon-Gs/β1/γ23.32022-06-15doi.org/10.1038/s41467-022-30929-w
7X2FAAmineDopamineD1Homo sapiensDopamineMevidalenGs/β1/γ232022-06-15doi.org/10.1038/s41467-022-30929-w
7WKDAPeptideThyrotropin Releasing HormoneTRHHomo sapiensTRH-chim(NtGi1-Gs-CtGq)/β1/γ23.012022-06-15doi.org/10.1038/s41422-022-00641-x
7X2CAAmineDopamineD1Homo sapiensFenoldopamFenoldopamGs/β1/γ23.22022-06-29doi.org/10.1038/s41467-022-30929-w
7XJKAPeptideGalaninGAL2Homo sapiensGalanin-chim(NtGi2L-Gs-CtGq)/β1/γ23.32022-06-29doi.org/10.1073/pnas.2121465119
7XJLAPeptideGalaninGAL2Homo sapiensSpexin-chim(NtGi2L-Gs-CtGq)/β1/γ23.52022-06-29doi.org/10.1073/pnas.2121465119
7X8RB1PeptideGlucagonGLP-1Homo sapiensBOC5-Gs/β1/γ22.612022-06-29doi.org/10.1073/pnas.2200155119
7X8SB1PeptideGlucagonGLP-1Homo sapiensWB4-24-Gs/β1/γ23.092022-06-29doi.org/10.1073/pnas.2200155119
7RANAAmine5-Hydroxytryptamine5-HT2AHomo sapiensPubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ23.452022-07-06doi.org/10.1038/s41586-022-05258-z
7XTQASteroidBile AcidGPBAHomo sapiensR399-Gs/β1/γ23.22022-07-06doi.org/10.1073/pnas.2117054119
7XBWAProteinChemokineCX3CR1Homo sapiens--Gi1/β1/γ22.82022-07-13doi.org/10.1126/sciadv.abn8048
7XBXAProteinChemokineCX3CR1Homo sapiensCX3CL1-Gi1/β1/γ23.42022-07-13doi.org/10.1126/sciadv.abn8048
7XBDAPeptideGalaninGAL2Homo sapiensGalanin-chim(NtGi2L-Gs-CtGq)/β1/γ23.112022-07-13doi.org/10.1371/journal.pbio.3001714
7WJ5APeptideSomatostatinSST2Homo sapiensSomatostatin-14-Gi1/β1/γ23.722022-07-13doi.org/10.7554/eLife.76823
7UM5AAmine5-Hydroxytryptamine5-HT5AHomo sapiens5-CT-chim(NtGi1-Go)/β1/γ22.732022-07-20doi.org/10.1038/s41594-022-00796-6
7UM6AAmine5-Hydroxytryptamine5-HT5AHomo sapiensLisuride-chim(NtGi1-Go)/β1/γ22.792022-07-20doi.org/10.1038/s41594-022-00796-6
7UM7AAmine5-Hydroxytryptamine5-HT5AHomo sapiensMethylergometrine-chim(NtGi1-Go)/β1/γ22.752022-07-20doi.org/10.1038/s41594-022-00796-6
7XOUAPeptideCholecystokininCCKAHomo sapiensCholecystokinin-8-Gs/β1/γ23.22022-07-20doi.org/10.1038/s41421-022-00420-3
7XOVAPeptideCholecystokininCCKAHomo sapiensSR146131-Gs/β1/γ232022-07-20doi.org/10.1038/s41421-022-00420-3
7XOWAPeptideCholecystokininCCKBHomo sapiensSulfated Gastrin-(10-17)-chim(NtGi1-Gq)/β1/γ23.12022-07-20doi.org/10.1038/s41421-022-00420-3
7Y12AOrphanOrphanMRGPRDHomo sapiensβ-Alanine-Gi1/β1/γ23.12022-07-20doi.org/10.1038/s42003-022-03668-3
7Y15AOrphanOrphanMRGPRDHomo sapiens--Gi1/β1/γ22.92022-07-20doi.org/10.1038/s42003-022-03668-3
7XT8AAmine5-Hydroxytryptamine5-HT4Homo sapiensSerotonin-Gs/β1/γ23.12022-07-27doi.org/10.1016/j.molcel.2022.05.031
7XT9AAmine5-Hydroxytryptamine5-HT4Homo sapiensSerotonin-Gs/β1/γ23.22022-07-27doi.org/10.1016/j.molcel.2022.05.031
7XTAAAmine5-Hydroxytryptamine5-HT4Homo sapiensSerotonin-Gi1/β1/γ23.22022-07-27doi.org/10.1016/j.molcel.2022.05.031
7XTBAAmine5-Hydroxytryptamine5-HT6Homo sapiensSerotonin-Gs/β1/γ23.32022-07-27doi.org/10.1016/j.molcel.2022.05.031
7XTCAAmine5-Hydroxytryptamine5-HT7Homo sapiens5-CT-Gs/β1/γ23.22022-07-27doi.org/10.1016/j.molcel.2022.05.031
7W0MAPeptideApelinApelinHomo sapiensPubChem 122701908-Gi1/β1/γ23.712022-07-27doi.org/10.1038/s41594-022-00797-5
7W0OAPeptideApelinApelinHomo sapiensElabela-Gi1/β1/γ23.782022-07-27doi.org/10.1038/s41594-022-00797-5
7W0PAPeptideApelinApelinHomo sapiensElabela-Gi1/β1/γ23.162022-07-27doi.org/10.1038/s41594-022-00797-5
7W0LAPeptideApelinApelin; ApelinHomo sapiensPubChem 122701908-Gi1/β1/γ23.572022-07-27doi.org/10.1038/s41594-022-00797-5
7W0NAPeptideApelinApelin; ApelinHomo sapiensElabela-Gi1/β1/γ24.212022-07-27doi.org/10.1038/s41594-022-00797-5
8DCRAAmineAdrenergicβ1Meleagris gallopavoDobutamine-Gs/β1/γ22.62022-07-27doi.org/10.1038/s41467-022-31823-1
8DCSAAmineAdrenergicβ1Meleagris gallopavoCyanopindolol-Gs/β1/γ22.52022-07-27doi.org/10.1038/s41467-022-31823-1
7VVJB1PeptideParathyroid HormonePTH1Homo sapiensPTHrP(1-36)-Gs/β1/γ23.22022-08-03doi.org/10.1016/j.molcel.2022.07.003
7VVKB1PeptideParathyroid HormonePTH1Homo sapiensPTH-Gs/β1/γ23.32022-08-03doi.org/10.1016/j.molcel.2022.07.003
7VVLB1PeptideParathyroid HormonePTH1Homo sapiensPTH-Gs/β1/γ22.82022-08-03doi.org/10.1016/j.molcel.2022.07.003
7VVMB1PeptideParathyroid HormonePTH1Homo sapiensPTH-Gs/β1/γ23.22022-08-03doi.org/10.1016/j.molcel.2022.07.003
7VVNB1PeptideParathyroid HormonePTH1Homo sapiensPTH-Gs/β1/γ23.82022-08-03doi.org/10.1016/j.molcel.2022.07.003
7VVOB1PeptideParathyroid HormonePTH1Homo sapiensPTH-Gs/β1/γ24.12022-08-03doi.org/10.1016/j.molcel.2022.07.003
7XMRAPeptideSomatostatinSST2Homo sapiensSomatostatin-14-Gi1/β1/γ23.12022-08-03doi.org/10.1038/s41422-022-00679-x
7XMSAPeptideSomatostatinSST4Homo sapiensSomatostatin-14-Gi1/β1/γ22.92022-08-03doi.org/10.1038/s41422-022-00679-x
7XMTAPeptideSomatostatinSST4Homo sapiensJ-2156-Gi1/β1/γ22.82022-08-03doi.org/10.1038/s41422-022-00679-x
7T9IAProteinGlycoprotein HormoneTSHHomo sapiensTSH-Gs/β1/γ22.92022-08-03doi.org/10.1038/s41586-022-05159-1
7T9NAProteinGlycoprotein HormoneTSHHomo sapiensM22 FabDPPCGs/β1/γ22.92022-08-03doi.org/10.1038/s41586-022-05159-1
7UTZAProteinGlycoprotein HormoneTSHHomo sapiensTSHDPPCGs/β1/γ22.42022-08-03doi.org/10.1038/s41586-022-05159-1
7XKDB2AdhesionAdhesionADGRG2Mus musculusDehydroepiandrosterone-Gs/β1/γ22.42022-08-10doi.org/10.1038/s41589-022-01084-6
7XKEB2AdhesionAdhesionADGRG2Mus musculusDehydroepiandrosterone-chim(NtGi1-Gs)/β1/γ22.92022-08-10doi.org/10.1038/s41589-022-01084-6
7XKFB2AdhesionAdhesionADGRG2Mus musculusDehydroepiandrosterone-Gs/β1/γ22.42022-08-10doi.org/10.1038/s41589-022-01084-6
7QVMAPeptideVasopressin and OxytocinOTHomo sapiensOxytocin-chim(NtGi1-Go-CtGq)/β1/γ23.252022-08-10doi.org/10.1038/s41467-022-31325-0
7WU9ALipidProstanoidEP3Homo sapiens--Gi1/β1/γ23.382022-08-17doi.org/10.1016/j.celrep.2022.111323
7XW6AProteinGlycoprotein HormoneTSHHomo sapiensM22 FabML109Gs/β1/γ22.782022-08-17doi.org/10.1038/s41586-022-05173-3
8DPFAAmine5-Hydroxytryptamine5-HT2CHomo sapiensLorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ22.842022-08-24doi.org/10.1016/j.celrep.2022.111211
8DPGAAmine5-Hydroxytryptamine5-HT2CHomo sapiensPsilocin-chim(NtGi2L-Gs-CtGq)/β1/γ23.62022-08-24doi.org/10.1016/j.celrep.2022.111211
8DPHAAmine5-Hydroxytryptamine5-HT2CHomo sapiensLorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ23.22022-08-24doi.org/10.1016/j.celrep.2022.111211
8DPIAAmine5-Hydroxytryptamine5-HT2CHomo sapiensLorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ23.42022-08-24doi.org/10.1016/j.celrep.2022.111211
7YP7B2AdhesionAdhesionADGRG2Mus musculus--Gs/β1/γ23.12022-08-24doi.org/10.1038/s41589-022-01084-6
7XA3AProteinChemokineCCR2Homo sapiensCCL2-Gi1/β1/γ22.92022-08-24doi.org/10.1038/s41421-022-00403-4
7X9YAProteinChemokineCCR3Homo sapiens--Gi1/β1/γ23.12022-08-24doi.org/10.1038/s41421-022-00403-4
7XZ5ALipidGPR119GPR119Homo sapiensLysophosphatidylcholine-Gs/β1/γ23.12022-08-24doi.org/10.1038/s41594-022-00816-5
7XZ6ALipidGPR119GPR119Homo sapiensAPD668-Gs/β1/γ22.82022-08-24doi.org/10.1038/s41594-022-00816-5
7XW5AProteinGlycoprotein HormoneTSHHomo sapiensTSHML109Gs/β1/γ22.962022-08-24doi.org/10.1038/s41586-022-05173-3
7XATAPeptideSomatostatinSST2Homo sapiensSomatostatin-14-Gi1/β1/γ22.852022-08-31doi.org/10.1038/s41421-022-00405-2
7XAUAPeptideSomatostatinSST2Homo sapiensOctreotide-Gi1/β1/γ22.972022-08-31doi.org/10.1038/s41421-022-00405-2
7XAVAPeptideSomatostatinSST2Homo sapiensLanreotide-Gi1/β1/γ22.872022-08-31doi.org/10.1038/s41421-022-00405-2
7X1TAPeptideThyrotropin Releasing HormoneTRHHomo sapiensTaltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ23.262022-08-31doi.org/10.1038/s41422-022-00646-6
7X1UAPeptideThyrotropin Releasing HormoneTRHHomo sapiensTRH-chim(NtGi2L-Gs-CtGq)/β1/γ23.192022-08-31doi.org/10.1038/s41422-022-00646-6
7X5HAAmine5-Hydroxytryptamine5-HT5AHomo sapiens5-CT-Gi1/β1/γ23.12022-09-14doi.org/10.1038/s41421-022-00412-3
7SRRAAmine5-Hydroxytryptamine5-HT2BHomo sapiensLSD-chim(NtGi2L-Gs-CtGq)/β1/γ22.92022-09-21doi.org/10.1016/j.neuron.2022.08.006
7VFXAPeptideFormylpeptideFPR1-ALXHomo sapiensfMIFL-Gi1/β1/γ22.82022-09-21doi.org/10.1038/s41467-022-32822-y
7WXUB2AdhesionAdhesionADGRF1Homo sapiens--chim(NtGi1-Gs-CtGq)/β1/γ22.852022-09-28doi.org/10.1038/s41467-022-33173-4
7WXWB2AdhesionAdhesionADGRF1Homo sapiens--chim(NtGi1-Gs)/β1/γ22.842022-09-28doi.org/10.1038/s41467-022-33173-4
7WY0B2AdhesionAdhesionADGRF1Homo sapiens--chim(NtGi1L-G13)/β1/γ22.832022-09-28doi.org/10.1038/s41467-022-33173-4
7WZ7B2AdhesionAdhesionADGRF1Homo sapiens--chim(NtGi1-G12)/β1/γ22.832022-09-28doi.org/10.1038/s41467-022-33173-4
7X2VB2AdhesionAdhesionADGRF1Homo sapiens--Gi1/β1/γ23.092022-09-28doi.org/10.1038/s41467-022-33173-4
7W6PAAmineAdrenergicα2aHomo sapiensN-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ23.472022-09-28doi.org/10.1126/science.abn7065
7W7EAAmineAdrenergicα2aHomo sapiensPubChem 164946676-Go/β1/γ23.42022-09-28doi.org/10.1126/science.abn7065
7VIEALipidLysophospholipidS1P1Homo sapiensS1P-Gi1/β1/γ22.862022-09-28doi.org/10.1073/pnas.2117716119
7VIFALipidLysophospholipidS1P1Homo sapiensFTY720-P-Gi1/β1/γ22.832022-09-28doi.org/10.1073/pnas.2117716119
7VIGALipidLysophospholipidS1P1Homo sapiensCBP-307-Gi1/β1/γ22.892022-09-28doi.org/10.1073/pnas.2117716119
7VIHALipidLysophospholipidS1P1Homo sapiensCBP-307-Gi1/β1/γ22.982022-09-28doi.org/10.1073/pnas.2117716119
7YU3ALipidLysophospholipidLPA1Homo sapiensONO-0740556-Gi1/β1/γ23.52022-10-05doi.org/10.1038/s41467-022-33121-2
7YU5ALipidLysophospholipidLPA1Homo sapiensONO-0740556-Gi1/β1/γ23.72022-10-05doi.org/10.1038/s41467-022-33121-2
7YU6ALipidLysophospholipidLPA1Homo sapiensONO-0740556-Gi1/β1/γ23.92022-10-05doi.org/10.1038/s41467-022-33121-2
7YU7ALipidLysophospholipidLPA1Homo sapiensONO-0740556-Gi1/β1/γ24.52022-10-05doi.org/10.1038/s41467-022-33121-2
7YU8ALipidLysophospholipidLPA1Homo sapiensONO-0740556-Gi1/β1/γ25.62022-10-05doi.org/10.1038/s41467-022-33121-2
7Y89AOrphanOrphanGPR17Homo sapiens--Gi1/β1/γ23.022022-10-12doi.org/10.1002/mco2.159
7XP4T2SensoryTaste2TAS2R46Homo sapiens--chim(Gs-CtGt3)/β1/γ23.012022-10-12doi.org/10.1126/science.abo1633
7XP5T2SensoryTaste2TAS2R46Homo sapiens--chim(Gs-CtGt3)/β1/γ23.082022-10-12doi.org/10.1126/science.abo1633
7XP6T2SensoryTaste2TAS2R46Homo sapiensStrychnine-chim(Gs-CtGt3)/β1/γ23.012022-10-12doi.org/10.1126/science.abo1633
7Y24APeptideSomatostatinSST2Homo sapiensOctreotide-Go/β1/γ23.252022-10-19doi.org/10.1038/s41589-022-01130-3
7Y26APeptideSomatostatinSST2Homo sapiensOctreotide-chim(NtGi2L-Gs-CtGq)/β1/γ23.32022-10-19doi.org/10.1038/s41589-022-01130-3
7Y27APeptideSomatostatinSST2Homo sapiensSomatostatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ23.482022-10-19doi.org/10.1038/s41589-022-01130-3
7WY5B2AdhesionAdhesionADGRL3Mus musculus--chim(NtGi1-Gs-CtGq)/β1/γ22.832022-10-26doi.org/10.1016/j.molcel.2022.10.009
7WY8B2AdhesionAdhesionADGRL3Mus musculus--chim(NtGi1-Gs)/β1/γ22.832022-10-26doi.org/10.1016/j.molcel.2022.10.009
7WYBB2AdhesionAdhesionADGRL3Mus musculus--Gi1/β1/γ22.972022-10-26doi.org/10.1016/j.molcel.2022.10.009
7X10B2AdhesionAdhesionADGRL3Mus musculus--chim(NtGi1-G12)/β1/γ22.932022-10-26doi.org/10.1016/j.molcel.2022.10.009
7WZ4AOrphanOrphanGPR88Homo sapiens--Gi1/β1/γ232022-10-26doi.org/10.1038/s41467-022-30081-5
8DWCAOrphanOrphanMRGPRX1Homo sapiensBAM8-22-chim(NtGi2L-Gs-CtGq)/β1/γ22.872022-11-02doi.org/10.1038/s41589-022-01173-6
8DWGAOrphanOrphanMRGPRX1Homo sapiensBAM8-22ML382chim(NtGi2L-Gs-CtGq)/β1/γ22.712022-11-02doi.org/10.1038/s41589-022-01173-6
8DWHAOrphanOrphanMRGPRX1Homo sapiensPubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ23.252022-11-02doi.org/10.1038/s41589-022-01173-6
7TRYB1PeptideCorticotropin Releasing FactorCRF2Homo sapiensUrocortin-chim(NtGi1-G11)/β1/γ23.72022-11-09doi.org/10.1038/s41467-022-33851-3
7TS0B1PeptideCorticotropin Releasing FactorCRF2Homo sapiensUrocortin-chim(NtGi1L-Go)/β1/γ22.82022-11-09doi.org/10.1038/s41467-022-33851-3
8EF5APeptideOpioidμHomo sapiensFentanyl-Gi1/β1/γ23.32022-11-09doi.org/10.1016/j.cell.2022.09.041
8EF6APeptideOpioidμHomo sapiensMorphine-Gi1/β1/γ23.22022-11-09doi.org/10.1016/j.cell.2022.09.041
8EFBAPeptideOpioidμHomo sapiensOliceridine-Gi1/β1/γ23.22022-11-09doi.org/10.1016/j.cell.2022.09.041
8EFLAPeptideOpioidμHomo sapiensSR17018-Gi1/β1/γ23.22022-11-09doi.org/10.1016/j.cell.2022.09.041
8EFOAPeptideOpioidμHomo sapiensPZM21-Gi1/β1/γ22.82022-11-09doi.org/10.1016/j.cell.2022.09.041
8EFQAPeptideOpioidμHomo sapiensDAMGO-Gi1/β1/γ23.32022-11-09doi.org/10.1016/j.cell.2022.09.041
8E3XB1PeptideVIP and PACAPPAC1Homo sapiensPACAP27-Gs/β1/γ22.32022-11-23doi.org/10.1038/s41467-022-34629-3
8E3YB1PeptideVIP and PACAPVPAC1Homo sapiensPACAP27-Gs/β1/γ22.32022-11-23doi.org/10.1038/s41467-022-34629-3
8E3ZB1PeptideVIP and PACAPVPAC1Homo sapiensVIP-Gs/β1/γ22.72022-11-23doi.org/10.1038/s41467-022-34629-3
8E9WAAmineAcetylcholine (muscarinic)M3Homo sapiens2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ22.692022-11-30doi.org/10.1038/s41586-022-05489-0
8E9YAAmineAcetylcholine (muscarinic)M3Homo sapiensClozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ22.792022-11-30doi.org/10.1038/s41586-022-05489-0
8E9ZAAmineAcetylcholine (muscarinic)M3Homo sapiensIperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ22.692022-11-30doi.org/10.1038/s41586-022-05489-0
8E9XAAmineAcetylcholine (muscarinic)M4Homo sapiens2-Deoxycytidine-chim(NtGi1-Go)/β1/γ22.72022-11-30doi.org/10.1038/s41586-022-05489-0
7T2GAPeptideOpioidμMus musculusMitragynine Pseudoindoxyl-Gi1/β1/γ22.52022-12-07doi.org/10.1038/s41589-022-01208-y
7T2HAPeptideOpioidμMus musculusLofentanil-Gi1/β1/γ22.52022-12-07doi.org/10.1038/s41589-022-01208-y
7U2KAPeptideOpioidμMus musculusC6-guano-Gi1/β1/γ23.32022-12-07doi.org/10.1038/s41586-022-05588-y
8F7SAPeptideOpioidδHomo sapiensDeltorphin-Gi1/β1/γ232022-12-14doi.org/10.1016/j.cell.2022.12.026
8F7WAPeptideOpioidκHomo sapiensDynorphin-Gi1/β1/γ23.192022-12-14doi.org/10.1016/j.cell.2022.12.026
8F7QAPeptideOpioidμHomo sapiensβ-Endorphin-Gi1/β1/γ23.222022-12-14doi.org/10.1016/j.cell.2022.12.026
8F7RAPeptideOpioidμHomo sapiensEndomorphin-Gi1/β1/γ23.282022-12-14doi.org/10.1016/j.cell.2022.12.026
8F7XAPeptideOpioidNOPHomo sapiensNociceptin-Gi1/β1/γ23.282022-12-14doi.org/10.1016/j.cell.2022.12.026
7WCMALipidGPR119GPR119Homo sapiensMBX-2982-Gs/β1/γ22.332022-12-21doi.org/10.1038/s41467-022-34696-6
7WCNALipidGPR119GPR119Homo sapiensAR231453-Gs/β1/γ22.872022-12-21doi.org/10.1038/s41467-022-34696-6
8HA0B1PeptideParathyroid HormonePTH1Homo sapiensPTH-chim(NtGi1-Gs)/β1/γ22.622022-12-21doi.org/10.1038/s41401-022-01032-z
8HAFB1PeptideParathyroid HormonePTH1Homo sapiensPTHrP(1-36)-chim(NtGi1-Gs)/β1/γ23.252022-12-21doi.org/10.1038/s41401-022-01032-z
8HAOB1PeptideParathyroid HormonePTH1Homo sapiensPTH-chim(NtGi1-Gs)/β1/γ23.762022-12-21doi.org/10.1038/s41401-022-01032-z
7XW9APeptideThyrotropin Releasing HormoneTRHHomo sapiensTRH-chim(NtGi1L-Gs-CtGq)/β1/γ22.72022-12-28doi.org/10.1038/s41421-022-00477-0
8GY7APeptideMelanocortinMC2Homo sapiensCorticotropinCachim(NtGi1-Gs)/β1/γ2; MRAP13.32023-01-11doi.org/10.1038/s41422-022-00751-6
8HDOANucleotideAdenosineA2BHomo sapiensBAY 60-6583-Gs/β1/γ22.872023-01-18doi.org/10.1038/s41421-022-00503-1
8HDPANucleotideAdenosineA2BHomo sapiensAdenosine-Gs/β1/γ23.22023-01-18doi.org/10.1038/s41421-022-00503-1
7T8XAAmineAcetylcholine (muscarinic)M2Homo sapiensAcetylcholine-chim(NtGi1-Go)/β1/γ23.212023-01-25doi.org/10.1038/s41467-022-35726-z
7T90AAmineAcetylcholine (muscarinic)M2Homo sapiensAcetylcholine-chim(NtGi1-Go)/β1/γ23.322023-01-25doi.org/10.1038/s41467-022-35726-z
7T94AAmineAcetylcholine (muscarinic)M2Homo sapiensAcetylcholineLY2119620chim(NtGi1-Go)/β1/γ23.162023-01-25doi.org/10.1038/s41467-022-35726-z
8H8JAOrphanOrphanGPR35Homo sapiensLodoxamideCachim(NtGi1L-G13)/β1/γ23.22023-02-08doi.org/10.1038/s41421-022-00499-8
7XV3AOrphanOrphanGPR174Homo sapiensLysophosphatidylserine (WJS)-chim(NtGi1-Gs)/β1/γ22.762023-02-15doi.org/10.1038/s41467-023-36575-0
7TMWAPeptideRelaxinRXFP1Homo sapiens--Gs/β1/γ23.22023-02-15doi.org/10.1101/2022.01.22.477343
7W3ZAPeptideBombesinBB2Homo sapiensGastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ232023-02-22doi.org/10.1073/pnas.2216230120
7W40APeptideBombesinBB2Homo sapiensBombesin-chim(NtGi1L-Gq)/β1/γ232023-02-22doi.org/10.1073/pnas.2216230120
7XK2AAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensMK6892-Gi1/β1/γ23.12023-02-22doi.org/10.1038/s41467-023-37177-6
7XK8APeptideNeuromedin UNMUR2Homo sapiensNeuromedin-U-25-Gi1/β1/γ23.32023-02-22doi.org/10.1038/s41467-022-34814-4
7Y64APeptideComplement PeptideC5a1Homo sapiensC5a-Gi1/β1/γ22.92023-03-01doi.org/10.1038/s41422-023-00779-2
7Y65APeptideComplement PeptideC5a1Homo sapiensC5a (C-terminal peptide)-Gi1/β1/γ23.22023-03-01doi.org/10.1038/s41422-023-00779-2
7Y66APeptideComplement PeptideC5a1Homo sapiensBM213-Gi1/β1/γ22.92023-03-01doi.org/10.1038/s41422-023-00779-2
7Y67APeptideComplement PeptideC5a1Homo sapiensC089 peptide-Gi1/β1/γ22.82023-03-01doi.org/10.1038/s41422-023-00779-2
8HMVAOrphanOrphanGPR21Homo sapiens--Gs/β1/γ22.912023-03-01doi.org/10.1002/mco2.205
7YJ4APeptideRelaxinRXFP4Homo sapiensINSL5-Gi2/β1/γ23.192023-03-01doi.org/10.1038/s41467-023-36182-z
7YK6APeptideRelaxinRXFP4Homo sapiensPubChem 138319674-Gi2/β1/γ23.032023-03-01doi.org/10.1038/s41467-023-36182-z
7YK7APeptideRelaxinRXFP4Homo sapiensDC591053-Gi2/β1/γ22.752023-03-01doi.org/10.1038/s41467-023-36182-z
8G59ALipidFree Fatty AcidFFA4Homo sapiensTUG-891-chim(Gi1-CtGq)/β1/γ22.642023-03-08doi.org/10.1126/science.add6220
8HS3AOrphanOrphanGPR20Homo sapiens--Gi1/β1/γ23.142023-03-08doi.org/10.1038/s41421-023-00520-8
8HSCAOrphanOrphanGPR20Homo sapiens--Gi1/β1/γ2; Fab0463.222023-03-08doi.org/10.1038/s41421-023-00520-8
8ID3ALipidFree Fatty AcidFFA4Homo sapiens9-Hydroxystearic acid-Gi1/β1/γ23.12023-03-15doi.org/10.1126/science.add6220
8ID4ALipidFree Fatty AcidFFA4Homo sapiensLinoleic acid-Gi1/β1/γ23.12023-03-15doi.org/10.1126/science.add6220
8ID6ALipidFree Fatty AcidFFA4Homo sapiensOleic acid-Gi1/β1/γ22.82023-03-15doi.org/10.1126/science.add6220
8ID8ALipidFree Fatty AcidFFA4Homo sapiensTUG-891-Gi1/β1/γ232023-03-15doi.org/10.1126/science.add6220
8ID9ALipidFree Fatty AcidFFA4Homo sapiensIcosapent-Gi1/β1/γ232023-03-15doi.org/10.1126/science.add6220
8HIXAOrphanOrphanGPR21Homo sapiens--Gs/β1/γ23.122023-03-15doi.org/10.1038/s41467-023-35882-w
8HJ0AOrphanOrphanGPR21Homo sapiens--chim(Gs-CtG15)/β1/γ23.122023-03-15doi.org/10.1038/s41467-023-35882-w
8HJ2AOrphanOrphanGPR21Homo sapiens--chim(Gs-CtG15)/β1/γ23.82023-03-15doi.org/10.1038/s41467-023-35882-w
8HCQAPeptideEndothelinETAHomo sapiensEndothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ23.012023-03-22doi.org/10.1038/s41467-023-36998-9
8HBDAPeptideEndothelinETBHomo sapiensIRL1620-Gi1/β1/γ22.992023-03-22doi.org/10.1038/s41467-023-36998-9
8HCXAPeptideEndothelinETBHomo sapiensEndothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ23.52023-03-22doi.org/10.1038/s41467-023-36998-9
8F76O1OdorantOdorant family 51OR51E2Homo sapiensPropanoic acid-Gs/β1/γ23.12023-03-22doi.org/10.1038/s41586-023-05798-y
7YONAPeptideNeuropeptide YY2Homo sapiensPeptide-YY(3-36)-Gi1/β1/γ22.952023-03-22doi.org/10.1016/j.str.2022.11.010
7YOOAPeptideNeuropeptide YY2Homo sapiensNeuropeptide-Y-Gi1/β1/γ23.112023-03-22doi.org/10.1016/j.str.2022.11.010
7YS6AAmine5-Hydroxytryptamine5-HT6Homo sapiensSerotonin-chim(NtGi1-Gs)/β1/γ232023-03-29doi.org/10.1073/pnas.2209917120
7F6GAPeptideAngiotensinAT1Homo sapiens(Sar1)-Angiotensin II-Gq/β1/γ22.92023-03-29doi.org/10.15252/embj.2022112940
8I2GAProteinGlycoprotein HormoneFSHHomo sapiensFSHPubChem 67530240Gs/β1/γ22.82023-03-29doi.org/10.1038/s41467-023-36170-3
8FMZAPeptideNeurotensinNTS1Rattus norvegicusNeurotensin-(8-13)-chim(NtGi2L-Gs-CtGq)/β1/γ22.592023-03-29doi.org/10.1021/acs.biochem.3c00029
8FN0APeptideNeurotensinNTS1Rattus norvegicusNeurotensin-(8-13)SBI-553chim(NtGi1-Go)/β1/γ22.892023-03-29doi.org/10.1021/acs.biochem.3c00029
8FN1APeptideNeurotensinNTS1Rattus norvegicusNeurotensin-(8-13)-chim(NtGi1-Go)/β1/γ22.882023-03-29doi.org/10.1021/acs.biochem.3c00029
8FU6B1PeptideGlucagonGlucagonHomo sapiensZP3780-Gs/β1/γ22.92023-04-12doi.org/10.1016/j.cell.2023.02.028
8IBUAPeptideMotilinMotilinHomo sapiensErythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ23.512023-04-12doi.org/10.1126/sciadv.ade9020
8IBVAPeptideMotilinMotilinHomo sapiensMotilin-chim(NtGi1-Gs-CtGq)/β1/γ23.192023-04-12doi.org/10.1126/sciadv.ade9020
7YKDAProteinChemerinCML1Homo sapiensChemerin-9-Gi1/β1/γ22.812023-04-19doi.org/10.1073/pnas.2214324120
8G94ALipidLysophospholipidS1P1Homo sapiens-CD69Gi1/β1/γ23.152023-04-19doi.org/10.7554/eLife.88204
7YACAPeptideSomatostatinSST2Homo sapiensPaltusotine-Gi1/β1/γ23.242023-04-19doi.org/10.1038/s41467-023-36673-z
7YAEAPeptideSomatostatinSST2Homo sapiensOctreotide-Gi1/β1/γ23.372023-04-19doi.org/10.1038/s41467-023-36673-z
8FLQB1PeptideParathyroid HormonePTH1Homo sapiensPTH-Gs/β1/γ22.552023-04-26doi.org/10.1016/j.str.2023.04.002
8FLRB1PeptideParathyroid HormonePTH1Homo sapiensPTHrP(1-36)-Gs/β1/γ22.942023-04-26doi.org/10.1016/j.str.2023.04.002
8FLSB1PeptideParathyroid HormonePTH1Homo sapiensAbaloparatide-Gs/β1/γ23.092023-04-26doi.org/10.1016/j.str.2023.04.002
8FLTB1PeptideParathyroid HormonePTH1Homo sapiensM-PTH(1-14)-Gs/β1/γ23.032023-04-26doi.org/10.1016/j.str.2023.04.002
8FLUB1PeptideParathyroid HormonePTH1Homo sapiensLA-PTH Analog-Gs/β1/γ22.762023-04-26doi.org/10.1016/j.str.2023.04.002
7XY6ANucleotideAdenosineA2BHomo sapiensBAY 60-6583-chim(NtGi1-Gs)/β1/γ22.992023-05-03doi.org/10.1126/sciadv.add3709
7XY7ANucleotideAdenosineA2BHomo sapiensNECA-chim(NtGi1-Gs)/β1/γ23.262023-05-03doi.org/10.1126/sciadv.add3709
7XJJAPeptideGalaninGAL1Homo sapiensGalanin-Go/β1/γ23.32023-05-03doi.org/10.1073/pnas.2121465119
8DZPAPeptideOpioidκHomo sapiensmomSalB-Gi1/β1/γ22.712023-05-03doi.org/10.1038/s41586-023-06030-7
8DZQAPeptideOpioidκHomo sapiensmomSalB-Go/β1/γ22.822023-05-03doi.org/10.1038/s41586-023-06030-7
8DZRAPeptideOpioidκHomo sapiensGR89,696-chim(NtGi2-Gt3)/β1/γ22.612023-05-03doi.org/10.1038/s41586-023-06030-7
8DZSAPeptideOpioidκHomo sapiensGR89,696-chim(NtGi2-Gz)/β1/γ22.652023-05-03doi.org/10.1038/s41586-023-06030-7
8G2YB2AdhesionAdhesionADGRF1Homo sapiens-LPCchim(Gs-CtGq)/β1/γ23.442023-05-10doi.org/10.1038/s41467-023-38083-7
8HK2APeptideComplement PeptideC3aBHomo sapiensC3a-Gi1/β1/γ22.92023-05-10doi.org/10.1038/s41589-023-01339-w
8HK3APeptideComplement PeptideC3aBHomo sapiens--Gi1/β1/γ23.22023-05-10doi.org/10.1038/s41589-023-01339-w
8HK5APeptideComplement PeptideC5a1Homo sapiensC5a-Gi1/β1/γ232023-05-10doi.org/10.1038/s41589-023-01339-w
8GUQALipidCannabinoidCB2Homo sapiensOlorinab-Gi1/β1/γ23.082023-05-10doi.org/10.1038/s41467-023-37112-9
8GURALipidCannabinoidCB2Homo sapiensCP55940-Gi1/β1/γ22.842023-05-10doi.org/10.1038/s41467-023-37112-9
8GUSALipidCannabinoidCB2Homo sapiensHU-308-Gi1/β1/γ22.972023-05-10doi.org/10.1038/s41467-023-37112-9
8GUTALipidCannabinoidCB2Homo sapiensLEI-102-Gi1/β1/γ22.982023-05-10doi.org/10.1038/s41467-023-37112-9
7TRKAAmineAcetylcholine (muscarinic)M4Homo sapiensIperoxo-Gi1/β1/γ22.82023-05-17doi.org/10.2139/ssrn.4034884
7TRPAAmineAcetylcholine (muscarinic)M4Homo sapiensIperoxoLY2033298Gi1/β1/γ22.42023-05-17doi.org/10.2139/ssrn.4034884
7TRQAAmineAcetylcholine (muscarinic)M4Homo sapiensIperoxoVU0467154Gi1/β1/γ22.52023-05-17doi.org/10.2139/ssrn.4034884
7TRSAAmineAcetylcholine (muscarinic)M4Homo sapiensAcetylcholine-Gi1/β1/γ22.82023-05-17doi.org/10.2139/ssrn.4034884
8IA8APeptideComplement PeptideC3aBHomo sapiensE7 peptide-Gi1/β1/γ22.862023-05-24To be published
8GHVALipidCannabinoidCB1Homo sapiensAMG315-Gi1/β1/γ22.82023-05-24doi.org/10.1038/s41467-023-37864-4
8EITALipidFree Fatty AcidFFA1Homo sapiensDoconexent-chim(NtGi1L-Gs-CtGq)/β1/γ22.82023-05-24doi.org/10.1073/pnas.2219569120
8EJCALipidFree Fatty AcidFFA1Homo sapiensTAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ232023-05-24doi.org/10.1073/pnas.2219569120
8EJKALipidFree Fatty AcidFFA1Homo sapiensTAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ23.42023-05-24doi.org/10.1073/pnas.2219569120
7Y1FAPeptideOpioidκHomo sapiensDynorphin-Gi1/β1/γ23.32023-05-24doi.org/10.1093/procel/pwac033
8HJ5AOrphanOrphanMRGPRX1Homo sapiensPubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ232023-05-31doi.org/10.1371/journal.pbio.3001975
7XWOAPeptideTachykininNK2Homo sapiensNeurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ22.72023-05-31doi.org/10.1038/s41421-022-00437-8
8ITFAOrphanOrphanTAA9Mus musculusDMCHA-chim(NtGi1-Gs)/β1/γ23.462023-05-31doi.org/10.1038/s41586-023-06106-4
8IW1AOrphanOrphanTAA9Mus musculus--chim(NtGi1-Gs)/β1/γ23.42023-05-31doi.org/10.1038/s41586-023-06106-4
8IW4AOrphanOrphanTAA9Mus musculusSpermidine-chim(NtGi1-Gs)/β1/γ23.492023-05-31doi.org/10.1038/s41586-023-06106-4
8IW7AOrphanOrphanTAA9Mus musculus2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ22.972023-05-31doi.org/10.1038/s41586-023-06106-4
8IW9AOrphanOrphanTAA9Mus musculus--chim(NtGi1-Gs)/β1/γ23.082023-05-31doi.org/10.1038/s41586-023-06106-4
8IRRAAmineDopamineD1Homo sapiensRotigotine-Gs/β1/γ23.22023-06-07doi.org/10.1038/s41422-023-00808-0
8IRSAAmineDopamineD2Homo sapiensRotigotine-Gi1/β1/γ232023-06-07doi.org/10.1038/s41422-023-00808-0
8IRTAAmineDopamineD3Homo sapiensRotigotine-Gi1/β1/γ22.72023-06-07doi.org/10.1038/s41422-023-00808-0
8IRUAAmineDopamineD4Homo sapiensRotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ23.22023-06-07doi.org/10.1038/s41422-023-00808-0
8IRVAAmineDopamineD5Homo sapiensRotigotine-chim(NtGi1-Gs)/β1/γ23.12023-06-07doi.org/10.1038/s41422-023-00808-0
7Y3GAOrphanOrphanGPR12Homo sapiens--Gs/β1/γ22.772023-06-07doi.org/10.1016/j.scib.2022.12.023
7XXHANucleotideP2YP2Y1Homo sapiens2MeSADP-chim(NtGi1-G11)/β1/γ22.92023-06-07doi.org/10.1093/procel/pwac025
7XXIANucleotideP2YP2Y12Homo sapiens2MeSADP-Gi2/β1/γ232023-06-07doi.org/10.1093/procel/pwac025
8GW8B1PeptideParathyroid HormonePTH1Homo sapiens-PCO371Gs/β1/γ22.92023-06-14doi.org/10.1038/s41586-023-06169-3
8H4IALipidFree Fatty AcidFFA4Homo sapiensDoconexent-chim(NtGi1-Gs)/β1/γ23.062023-06-21doi.org/10.1038/s41422-023-00835-x
8H4KALipidFree Fatty AcidFFA4Homo sapiensGW9508-chim(NtGi1-Gs-CtGq)/β1/γ23.12023-06-21doi.org/10.1038/s41422-023-00835-x
8H4LALipidFree Fatty AcidFFA4Homo sapiensDoconexent-chim(NtGi1-Gs-CtGq)/β1/γ23.072023-06-21doi.org/10.1038/s41422-023-00835-x
8IYSALipidFree Fatty AcidFFA4Homo sapiensTUG-891GDPchim(NtGi1L-Gq)/β1/γ22.952023-06-21doi.org/10.1038/s41422-023-00835-x
8HMPAOrphanOrphanGPR52Homo sapiens-C17Gs/β1/γ22.772023-06-21doi.org/10.1002/mco2.260
8J18AOrphanOrphanGPR84Homo sapiens(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ22.892023-06-21doi.org/10.1038/s41467-023-38985-6
8J19AOrphanOrphanGPR84Homo sapiensLY237-Gi1/β1/γ23.232023-06-21doi.org/10.1038/s41467-023-38985-6
8J1AAOrphanOrphanGPR84Homo sapiens--Gi1/β1/γ23.242023-06-21doi.org/10.1038/s41467-023-38985-6
8JD3CAminoacidMetabotropic GlutamatemGlu2; mGlu3Homo sapiensGlutamateJNJ-40411813Gi1/β1/γ23.32023-06-21doi.org/10.1038/s41422-023-00830-2
8JD5CAminoacidMetabotropic GlutamatemGlu2; mGlu4Homo sapiensGlutamateJNJ-40411813; ADX88178Gi1/β1/γ23.62023-06-21doi.org/10.1038/s41422-023-00830-2
8JD6CAminoacidMetabotropic GlutamatemGlu4; mGlu4Homo sapiensPhosphoserineVU0364770Gi3/β1/γ23.42023-06-21doi.org/10.1038/s41422-023-00830-2
8JLZAAmine5-Hydroxytryptamine5-HT6Homo sapiensST1936-Gs/β1/γ23.092023-06-28doi.org/10.1016/j.bbrc.2023.05.126
7YM8AAmineAdrenergicAlpha1AHomo sapiensOxymetazoline-chim(Gs-CtGq)2.922023-07-05doi.org/10.1038/s41467-023-39310-x
7YMHAAmineAdrenergicAlpha1AHomo sapiensNorepinephrine-chim(Gs-CtGq)3.522023-07-05doi.org/10.1038/s41467-023-39310-x
7Y35B1PeptideParathyroid HormonePTH1Homo sapiensAbaloparatide-Gs/β1/γ22.92023-07-05To be published
7Y36B1PeptideParathyroid HormonePTH1Homo sapiensPTH-Gs/β1/γ22.82023-07-05To be published
7YDHB2AdhesionAdhesionADGRE5Homo sapiens--chim(NtGi2-G13)/β1/γ23.12023-07-12doi.org/10.1016/j.chembiol.2023.08.003
7YDJB2AdhesionAdhesionADGRE5Homo sapiens--chim(NtGi1-G12)/β1/γ23.032023-07-12To be published
7YDMB2AdhesionAdhesionADGRE5Homo sapiens--chim(NtGi1-Gs-CtGq)/β1/γ22.892023-07-12doi.org/10.1016/j.chembiol.2023.08.003
7YDPB2AdhesionAdhesionADGRE5Homo sapiens--chim(NtGi1-Gs)/β1/γ23.12023-07-12doi.org/10.1016/j.chembiol.2023.08.003
8IUKALipidProstanoidFP-alphaHomo sapiensPGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ22.672023-07-12doi.org/10.1038/s41467-023-38411-x
8IULALipidProstanoidFP-alphaHomo sapiensLatanoprost-chim(NtGi1-Gs-CtGq)/β1/γ22.782023-07-12doi.org/10.1038/s41467-023-38411-x
8IUMALipidProstanoidFP-alphaHomo sapiensTafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ23.142023-07-12doi.org/10.1038/s41467-023-38411-x
8IC0AProteinChemokineCXCR1Homo sapiensCXCL8-Gi1/β1/γ23.412023-07-19doi.org/10.1038/s41467-023-39799-2
8F0JB1PeptideCalcitoninCTHomo sapiensPramlintide Analogue San45-Gs/β1/γ222023-08-02doi.org/10.1038/s41589-023-01393-4
8F0KB1PeptideCalcitoninCT (AMY3)Homo sapiensPramlintide Analogue San385-Gs/β1/γ2; RAMP31.92023-08-02doi.org/10.1038/s41589-023-01393-4
8F2AB1PeptideCalcitoninCT (AMY3)Homo sapiensPramlintide Analogue San385-Gs/β1/γ2; RAMP32.22023-08-02doi.org/10.1038/s41589-023-01393-4
8F2BB1PeptideCalcitoninCT (AMY3)Homo sapiensPramlintide Analogue San45-Gs/β1/γ2; RAMP322023-08-02doi.org/10.1038/s41589-023-01393-4
8JR9B1PeptideParathyroid HormonePTH1Homo sapiens-PCO371chim(NtGi1-Gs)/β1/γ22.572023-08-02doi.org/10.1038/s41586-023-06467-w
8H0PAPeptideBombesinBB1Homo sapiensNMB30-chim(NtGi1-Gs-CtGq)/β1/γ23.152023-08-09doi.org/10.1038/s41422-022-00743-6
8H0QAPeptideBombesinBB2Homo sapiensGastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ23.32023-08-09doi.org/10.1038/s41422-022-00743-6
8JPBAPeptideNeurotensinNTS1Homo sapiensNeurotensin-(8-13)SBI-553; GDP; MgGq; GRK23.072023-08-09doi.org/10.1038/s41586-023-06395-9
8JPCAPeptideNeurotensinNTS1Homo sapiensNeurotensin-(8-13)SBI-553; GDP; MgGq; GRK23.072023-08-09doi.org/10.1038/s41586-023-06395-9
8THKAAmineAdrenergicAlpha1AHomo sapiensA-61603-chim(NtGi2L-Gs-CtGq)/β1/γ22.62023-08-16doi.org/10.1038/s41467-023-40524-2
8THLAAmineAdrenergicAlpha1AHomo sapiensEpinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ23.12023-08-16doi.org/10.1038/s41467-023-40524-2
8IY5APeptideEndothelinETBHomo sapiensEndothelin-1-Gi1/β1/γ22.82023-08-16doi.org/10.7554/eLife.85821
8IHFAAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensMK6892-Gi1/β1/γ22.972023-08-30doi.org/10.1038/s41467-023-41650-7
8IHHAAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensLUF6283-Gi1/β1/γ23.062023-08-30doi.org/10.1038/s41467-023-41650-7
8IHIAAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensAcifran-Gi1/β1/γ23.112023-08-30doi.org/10.1038/s41467-023-41650-7
8IHJAAlicarboxylic acidHydroxycarboxylic AcidHCA3Homo sapiensAcifran-Gi1/β1/γ23.072023-08-30doi.org/10.1038/s41467-023-41650-7
8JIPB1PeptideGlucagonGLP-1Homo sapiensMEDI0382-chim(NtGi1-Gs)/β1/γ22.852023-09-06doi.org/10.1073/pnas.2303696120
8JIRB1PeptideGlucagonGLP-1Homo sapiensSAR425899-chim(NtGi1-Gs)/β1/γ22.572023-09-06doi.org/10.1073/pnas.2303696120
8JITB1PeptideGlucagonGlucagonHomo sapiensMEDI0382-Gs/β1/γ22.912023-09-06doi.org/10.1073/pnas.2303696120
8JHYAAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiens-PubChem 25101223Gi1/β1/γ22.872023-09-06doi.org/10.1016/j.molcel.2023.07.030
8JIIAAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensNiacinPubChem 25101223Gi1/β1/γ23.172023-09-06doi.org/10.1016/j.molcel.2023.07.030
8JILAAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensNiacin-Gi1/β1/γ23.52023-09-06doi.org/10.1016/j.molcel.2023.07.030
8JIMAAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensMonomethyl fumarate-Gi1/β1/γ22.982023-09-06doi.org/10.1016/j.molcel.2023.07.030
8JIQB1PeptideGlucagonGlucagonHomo sapiensPeptide-15-Gs/β1/γ23.42023-09-13doi.org/10.1073/pnas.2303696120
8JIUB1PeptideGlucagonGlucagonHomo sapiensSAR425899-Gs/β1/γ22.762023-09-13doi.org/10.1073/pnas.2303696120
8IHBAAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensGSK256073-Gi1/β1/γ22.852023-09-13doi.org/10.1038/s41467-023-41650-7
8FX5AAmineAcetylcholine (muscarinic)M4Homo sapiensXanomelineXanomelineGi1/β1/γ22.452023-09-13doi.org/10.1038/s41467-023-41199-5
8IOCAPeptideMelanocortinMC3Homo sapiensγ-MSHCachim(NtGi1-Gs)/β1/γ22.862023-09-20doi.org/10.1038/s41421-023-00586-4
8INRAPeptideMelanocortinMC5Homo sapiensα-MSHCachim(NtGi1-Gs)/β1/γ22.732023-09-20doi.org/10.1038/s41421-023-00586-4
8IODAPeptideMelanocortinMC5Homo sapiensPG-901Cachim(NtGi1-Gs)/β1/γ22.592023-09-20doi.org/10.1038/s41421-023-00586-4
8SAIAOrphanOrphanGPR34Homo sapiensLysophosphatidylserine (S12)-Gi1/β1/γ23.272023-10-04doi.org/10.1073/pnas.2308435120
8TB0AOrphanOrphanGPR61Homo sapiens--chim(NtGi1-Gs)/β1/γ23.472023-10-04doi.org/10.1038/s41467-023-41646-3
8JZ7AAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensMK6892-Gi1/β1/γ22.62023-10-04doi.org/10.1038/s41392-023-01625-y
8HQEAOrphanOrphanGPR132Homo sapiens--Gi1/β1/γ22.972023-10-11doi.org/10.1038/s42255-023-00899-4
8HQMAOrphanOrphanGPR132Homo sapiensNPGLY-Gi1/β1/γ22.952023-10-11doi.org/10.1038/s42255-023-00899-4
8HQNAOrphanOrphanGPR132Homo sapiens9-S-HODE-Gi1/β1/γ232023-10-11doi.org/10.1038/s42255-023-00899-4
8HVIAOrphanOrphanGPR132Homo sapiensNOX-6-7-Gi1/β1/γ23.042023-10-11doi.org/10.1038/s42255-023-00899-4
8KH4AOrphanOrphanGPR161Homo sapiens--Gs/β1/γ23.12023-10-11doi.org/10.1038/s41467-023-41654-3
8KH5AOrphanOrphanGPR174Homo sapiensLysophosphatidylserine-Gs/β1/γ22.832023-10-11doi.org/10.1038/s41467-023-41654-3
8KGKAOrphanOrphanGPR61Homo sapiens--Gs/β1/γ23.162023-10-11doi.org/10.1038/s41467-023-41654-3
8H2GAAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensNiacin-Gi1/β1/γ23.012023-10-11doi.org/10.1038/s41467-023-42764-8
8I95APeptideComplement PeptideC3aBHomo sapiensEP54-Go/β1/γ22.882023-10-18doi.org/10.1016/j.cell.2023.09.020
8I97APeptideComplement PeptideC3aBHomo sapiens--Go/β1/γ23.12023-10-18doi.org/10.1016/j.cell.2023.09.020
8I9AAPeptideComplement PeptideC3aBHomo sapiensEP54-chim(NtGi1-Gs-CtGq)/β1/γ23.572023-10-18doi.org/10.1016/j.cell.2023.09.020
8I9LAPeptideComplement PeptideC3aBHomo sapiensC3a-Go/β1/γ23.182023-10-18doi.org/10.1016/j.cell.2023.09.020
8I9SAPeptideComplement PeptideC3aBHomo sapiens--Go/β1/γ23.262023-10-18doi.org/10.1016/j.cell.2023.09.020
8J6DAPeptideComplement PeptideC3aBHomo sapiensEP141-Go/β1/γ23.12023-10-18doi.org/10.1016/j.cell.2023.09.020
8HPTAPeptideComplement PeptideC5a1Mus musculusC5a (C-terminal peptide)-Go/β1/γ23.392023-10-18doi.org/10.1016/j.cell.2023.09.020
8HQCAPeptideComplement PeptideC5a1Mus musculusC5a-Go/β1/γ23.892023-10-18doi.org/10.1016/j.cell.2023.09.020
8IA2APeptideComplement PeptideC5a1Homo sapiensC5a-Go/β1/γ23.212023-10-18doi.org/10.1016/j.cell.2023.09.020
8JZZAPeptideComplement PeptideC5a1Homo sapiensC5a-des-Arg-Go/β1/γ23.312023-10-18doi.org/10.1016/j.cell.2023.09.020
8ITLB1PeptideGlucagonGIPHomo sapiens--Gs/β1/γ23.232023-10-18doi.org/10.1073/pnas.2306145120
8ITMB1PeptideGlucagonGIPHomo sapiens--Gs/β1/γ23.132023-10-18doi.org/10.1073/pnas.2306145120
8K4NAOrphanOrphanGPR34Homo sapiensPubChem 168719765-Gi1/β1/γ22.832023-10-25To be published
7YFCAAmineHistamineH4Homo sapiensHistamine-chim(NtGi1-Gs-CtGq)/β1/γ232023-10-25doi.org/10.1038/s41467-023-42260-z
7YFDAAmineHistamineH4Homo sapiensImetit-chim(NtGi1-Gs-CtGq)/β1/γ23.12023-10-25doi.org/10.1038/s41467-023-42260-z
8SG1AProteinChemerinCML1Homo sapiensChemerin-9-Gi1/β1/γ22.942023-11-01doi.org/10.1371/journal.pbio.3002188
8IZBAOrphanOrphanGPR174Homo sapiensLysophosphatidylserine (UBL)-Gs/β1/γ23.062023-11-01doi.org/10.1371/journal.pbio.3002387
8G05AOrphanOrphanGPR84Homo sapiens6-OAU-Gi1/β1/γ232023-11-01doi.org/10.1038/s41467-023-41201-0
8JISB1PeptideGlucagonGLP-1Homo sapiensPeptide-15-chim(NtGi1-Gs)/β1/γ22.462023-11-08doi.org/10.1073/pnas.2303696120
8WRBAOrphanOrphanGPR34Homo sapiensLysophosphatidylserine (UBL)-Gi1/β1/γ22.912023-11-08doi.org/10.1371/journal.pbio.3002387
8JSPAAmine5-Hydroxytryptamine5-HT1AHomo sapiensUlotaront-Gi1/β1/γ23.652023-11-15doi.org/10.1038/s41586-023-06804-z
8U26APeptideTachykininNK1Homo sapiensSubstance-P-Gs/β1/γ22.52023-11-15doi.org/10.1038/s41592-023-02082-9
8JLJAAmineTrace AmineTA1Mus musculusT1AM-chim(NtGi1-Gs)/β1/γ23.12023-11-15doi.org/10.1038/s41586-023-06804-z
8JLKAAmineTrace AmineTA1Mus musculusUlotaront-chim(NtGi1-Gs)/β1/γ23.222023-11-15doi.org/10.1038/s41586-023-06804-z
8JLNAAmineTrace AmineTA1Homo sapiensT1AM-Gs/β1/γ23.242023-11-15doi.org/10.1038/s41586-023-06804-z
8JLOAAmineTrace AmineTA1Homo sapiensUlotaront-Gs/β1/γ23.522023-11-15doi.org/10.1038/s41586-023-06804-z
8JLPAAmineTrace AmineTA1Homo sapiensRalmitaront-Gs/β1/γ23.232023-11-15doi.org/10.1038/s41586-023-06804-z
8JLQAAmineTrace AmineTA1Homo sapiensFenoldopam-Gs/β1/γ22.842023-11-15doi.org/10.1038/s41586-023-06804-z
8JLRAAmineTrace AmineTA1Homo sapiensA77636-chim(NtGi1-Gs)/β1/γ232023-11-15doi.org/10.1038/s41586-023-06804-z
8JSOAAmineTrace AmineTA1Homo sapiensAMPH-chim(NtGi1-Gs)/β1/γ23.42023-11-15doi.org/10.1038/s41586-023-06804-z
8W8BAAmine5-Hydroxytryptamine5-HT1AHomo sapiensSEP-363856-Gi1/β1/γ232023-11-22doi.org/10.1038/s41586-023-06775-1
8WPUCIonCalcium SensingCaS; CaSHomo sapiens-Tryptophan; Cinacalcet; PO4; Cachim(NtGi2L-Gs-CtGq)/β1/γ23.12023-11-22doi.org/10.1038/s41422-023-00892-2
8W87AAmineTrace AmineTA1Homo sapiensMETH-chim(NtGi1L-Gs)/β1/γ22.82023-11-22doi.org/10.1038/s41586-023-06775-1
8W88AAmineTrace AmineTA1Homo sapiensSEP-363856-Gs/β1/γ22.62023-11-22doi.org/10.1038/s41586-023-06775-1
8W89AAmineTrace AmineTA1Homo sapiens2-Phenylethylamine-chim(NtGi1L-Gs)/β1/γ232023-11-22doi.org/10.1038/s41586-023-06775-1
8W8AAAmineTrace AmineTA1Homo sapiensRO5256390-chim(NtGi1L-Gs)/β1/γ22.82023-11-22doi.org/10.1038/s41586-023-06775-1
8HNKAProteinChemokineCXCR3Homo sapiensCXCL11-Gi1/β1/γ23.012023-11-29doi.org/10.1038/s41594-023-01175-5
8HNLAProteinChemokineCXCR3Homo sapiensPS372424-Gi1/β1/γ22.982023-11-29doi.org/10.1038/s41594-023-01175-5
8HNMAProteinChemokineCXCR3Homo sapiensVUF11222-Gi1/β1/γ22.942023-11-29doi.org/10.1038/s41594-023-01175-5
8K2XAProteinChemokineCXCR3Homo sapiensCXCL10-Gi1/β1/γ23.22023-11-29doi.org/10.1038/s41594-023-01175-5
8HN8AAmineHistamineH4Homo sapiensHistamine-Gi1/β1/γ232023-12-20To be published
8HOCAAmineHistamineH4Homo sapiensImetit-Gi1/β1/γ232023-12-20To be published
8HTIO1OdorantOdorant family 52OR52CHomo sapiensOcatnoic acid-Gs/β1/γ22.972023-12-20doi.org/10.1038/s41467-023-43983-9
8HJ1AOrphanOrphanGPR21Homo sapiens--Gs/β1/γ23.272023-12-27doi.org/10.1038/s41467-023-35882-w
8GDCALipidProstanoidEP3Homo sapiensPGE2-Gi1/β1/γ23.52024-01-03doi.org/10.1073/pnas.2216329120
8GCMALipidProstanoidEP4Homo sapiensL-902688-Gi1/β1/γ23.52024-01-03doi.org/10.1073/pnas.2216329120
8GCPALipidProstanoidEP4Homo sapiensPGE2-Gi1/β1/γ23.12024-01-03doi.org/10.1073/pnas.2216329120
8GD9ALipidProstanoidEP4Homo sapiensRivenprost-Gs/β1/γ23.22024-01-03doi.org/10.1073/pnas.2216329120
8GDAALipidProstanoidEP4Homo sapiensL902688-Gs/β1/γ23.32024-01-03doi.org/10.1073/pnas.2216329120
8GDBALipidProstanoidEP4Homo sapiensPGE2-Gs/β1/γ23.12024-01-03doi.org/10.1073/pnas.2216329120
8IJ3AAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiens--Gi1/β1/γ23.282024-01-03doi.org/10.1038/s41421-023-00610-7
8IJAAAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensNiacin-Gi1/β1/γ22.692024-01-03doi.org/10.1038/s41421-023-00610-7
8IJBAAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensAcipimox-Gi1/β1/γ23.232024-01-03doi.org/10.1038/s41421-023-00610-7
8IJDAAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensMK6892-Gi1/β1/γ23.252024-01-03doi.org/10.1038/s41421-023-00610-7
8GE2AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ13.32024-03-06doi.org/10.1038/s41586-024-07153-1
8GE5AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ13.22024-03-06doi.org/10.1038/s41586-024-07153-1
9ASBCIonCalcium SensingCaS; CaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; R-568; PO4chim(NtGi1-Gs-CtGq)/β1/γ23.42024-04-17doi.org/10.1038/s41586-024-07331-1
9AVGCIonCalcium SensingCaS; CaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; R-568; PO4chim(NtGi1-Gs)/β1/γ23.62024-04-17doi.org/10.1038/s41586-024-07331-1
9AVLCIonCalcium SensingCaS; CaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; R-568; PO4Gi3/β2/γ23.82024-04-17doi.org/10.1038/s41586-024-07331-1
8UGYAAmine5-Hydroxytryptamine5-HT1EHomo sapiensMianserin-Gi1/β1/γ13.312024-05-01doi.org/10.1126/sciadv.adk4855
8UH3AAmine5-Hydroxytryptamine5-HT1EHomo sapiensSetiptiline-Gi1/β1/γ13.312024-05-01doi.org/10.1126/sciadv.adk4855
8FY8AAmine5-Hydroxytryptamine5-HT1AHomo sapiens5-MeO-DMTPtdIns4PGi1/β1/γ12.792024-05-15doi.org/10.1038/s41586-024-07403-2
8FYEAAmine5-Hydroxytryptamine5-HT1AHomo sapiens4-F,5-MeO-PyrTPtdIns4PGi1/β1/γ12.852024-05-15doi.org/10.1038/s41586-024-07403-2
8FYLAAmine5-Hydroxytryptamine5-HT1AHomo sapiensVilazodonePtdIns4PGi1/β1/γ12.942024-05-15doi.org/10.1038/s41586-024-07403-2
8FYTAAmine5-Hydroxytryptamine5-HT1AHomo sapiensLSDPtdIns4PGi1/β1/γ12.642024-05-15doi.org/10.1038/s41586-024-07403-2
8FYXAAmine5-Hydroxytryptamine5-HT1AHomo sapiensBuspironePtdIns4PGi1/β1/γ12.722024-05-15doi.org/10.1038/s41586-024-07403-2
8XBEAOrphanOrphanGPR34Homo sapiensS3E-Lysophosphatidylserine-Gi1/β1/γ13.42024-05-15doi.org/10.1038/s41467-024-45046-z
9BKJAPeptideCholecystokininCCKAHomo sapiensCholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ22.592024-05-22doi.org/10.1371/journal.pbio.3002673
9BKKAPeptideCholecystokininCCKAHomo sapiensCholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ22.512024-05-22doi.org/10.1371/journal.pbio.3002673
8YRGAOrphanOrphanMRGPRX4Homo sapiensFospropofol-chim(NtGi1-Gs-CtGq)/β1/γ23.142024-05-22doi.org/10.1126/scitranslmed.adk8198
8JPNAAlicarboxylic acidSuccinateSuccinateHomo sapiensCis-Epoxysuccinic acid-Gi1/β1/γ12.92024-05-22doi.org/10.1038/s41422-024-00968-7
8JPPAAlicarboxylic acidSuccinateSuccinateHomo sapiensSuccinic acid-chim(Gs-CtGq)/β1/γ13.22024-05-22doi.org/10.1038/s41422-024-00968-7
8PJKAAmine5-Hydroxytryptamine5-HT1AHomo sapiensST171-Gi1/β1/γ12.42024-05-29doi.org/10.1126/sciadv.adv9267
8PKMAAmine5-Hydroxytryptamine5-HT1AHomo sapiensBefiradol-Gi1/β1/γ12.92024-05-29doi.org/10.1126/sciadv.adv9267
8UWLAAmine5-Hydroxytryptamine5-HT2AHomo sapiensLisuride-chim(NtGi2-Gs-CtGq)/β1/γ22.82024-05-29doi.org/10.1126/science.adn6354
8V6UAAmine5-Hydroxytryptamine5-HT2AHomo sapiensPubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ232024-05-29doi.org/10.1126/science.adn6354
8K9KAPeptideOpioidμHomo sapiensDAMGO-Gi3/β1/γ12.982024-05-29doi.org/10.1038/s41467-024-47792-6
8K9LAPeptideOpioidμHomo sapiensDAMGOBMS-986122Gi3/β1/γ13.052024-05-29doi.org/10.1038/s41467-024-47792-6
8YKWAAlicarboxylic acidSuccinateSuccinateHomo sapiensSuccinic acid-Gi1/β1/γ12.752024-05-29doi.org/10.1038/s41422-024-00984-7
8YKXAAlicarboxylic acidSuccinateSuccinateHomo sapiensMaleic acid-Gi1/β1/γ12.692024-05-29doi.org/10.1038/s41422-024-00984-7
8IKGALipidCannabinoidCB1Homo sapiens-PubChem 703205Gi1/β1/γ13.42024-06-05doi.org/10.1073/pnas.2321532121
8IKHALipidCannabinoidCB1Homo sapiens-PubChem 171393541Gi1/β1/γ13.32024-06-05doi.org/10.1073/pnas.2321532121
8YUTAAmineHistamineH2Homo sapiensAmthamine-Gs/β1/γ22.72024-06-05doi.org/10.1002/advs.202310120
8YUUAAmineHistamineH3Homo sapiensHistamine-Gi1/β1/γ12.72024-06-05doi.org/10.1002/advs.202310120
8YUVAAmineHistamineH3Homo sapiensImmepip-Gi1/β1/γ232024-06-05doi.org/10.1002/advs.202310120
8X8LAPeptideSomatostatinSST5Homo sapiensCortistatin-14-chim(NtGi1-Gs-CtGi1)/β1/γ22.72024-06-12doi.org/10.1073/pnas.2321710121
8X8NAPeptideSomatostatinSST5Homo sapiensOctreotide-chim(NtGi1-Gs-CtGi1)/β1/γ22.92024-06-12doi.org/10.1073/pnas.2321710121
8ZR5ALipidGPR119GPR119Homo sapiensFiruglipel-Gs/β1/γ23.312024-06-19To be published
8ZRKALipidGPR119GPR119Homo sapiensGSK1292263-Gs/β1/γ22.822024-06-19To be published
8WSSAPeptideMelanin Concentrating HormoneMCH1Homo sapiensMCH-Gi1/β1/γ13.012024-06-19doi.org/10.1038/s41421-024-00679-8
8WSTAPeptideMelanin Concentrating HormoneMCH2Homo sapiensMCH-chim(NtGi1L-Gs-CtGq)/β1/γ22.42024-06-19doi.org/10.1038/s41421-024-00679-8
8WZ2APeptideP518QRFPHomo sapiensOrexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ22.732024-06-19doi.org/10.1038/s41421-024-00670-3
9ERXALipidCannabinoidCB1Homo sapiensD9-THC analog-Gi1/β1/γ22.92024-06-26doi.org/10.21203/rs.3.rs-4277209/v1
8ZJDAPeptideKisspeptinKiss1Homo sapiensKisspeptin-1-chim(NtGi1-Gq)/β1/γ13.062024-07-03doi.org/10.1016/j.celrep.2024.114389
8ZJEAPeptideKisspeptinKiss1Homo sapiensTAK448-chim(NtGi1-Gq)/β1/γ13.072024-07-03doi.org/10.1016/j.celrep.2024.114389
8ZH8APeptideP518QRFPHomo sapiensQRFP26-Gq/β1/γ13.192024-07-03doi.org/10.1038/s41467-024-49030-5
8ZQEAOrphanOrphanGPR15Homo sapiensGPR15L(CT)-Gi1/β1/γ12.92024-07-10doi.org/10.1038/s41421-024-00698-5
8ZBEAPeptideSomatostatinSST5Homo sapiensOctreotide-Gi1/β1/γ13.242024-07-10doi.org/10.1038/s41401-024-01314-8
8ZCJAPeptideSomatostatinSST5Homo sapiensPasireotide-Gi1/β1/γ13.092024-07-10doi.org/10.1038/s41401-024-01314-8
8XQLT2SensoryTaste2TAS2R14Homo sapiensCholesterolAristolochic acid AGt3/β1/γ12.992024-07-10doi.org/10.1038/s41586-024-07569-9
8XQNT2SensoryTaste2TAS2R14Homo sapiensCholesterolAristolochic acid AGi1/β1/γ13.052024-07-10doi.org/10.1038/s41586-024-07569-9
8XQOT2SensoryTaste2TAS2R14Homo sapiensCholesterolAristolochic acid AGi1/β1/γ12.772024-07-10doi.org/10.1038/s41586-024-07569-9
8XQPT2SensoryTaste2TAS2R14Homo sapiensCholesterolAristolochic acid AGt3/β1/γ13.292024-07-10doi.org/10.1038/s41586-024-07569-9
8XQRT2SensoryTaste2TAS2R14Homo sapiens-Flufenamic acidGt3/β1/γ13.22024-07-10doi.org/10.1038/s41586-024-07569-9
8XQST2SensoryTaste2TAS2R14Homo sapiensCholesterolFlufenamic acidGi1/β1/γ13.32024-07-10doi.org/10.1038/s41586-024-07569-9
8XQTT2SensoryTaste2TAS2R14Homo sapiensCholesterol-Gi1/β1/γ12.942024-07-10doi.org/10.1038/s41586-024-07569-9
8K3ZAProteinChemokineCXCR4Homo sapiensCXCL12-Gi1/β1/γ12.812024-07-17doi.org/10.1016/j.celrep.2024.114578
8K4OAOtherUnclassifiedKSHVHuman gammaherpesvirus 8CXCL1-Gi1/β1/γ13.012024-07-24doi.org/10.1073/pnas.2403217121
8K4PAOtherUnclassifiedKSHVHuman gammaherpesvirus 8--Gi1/β1/γ12.812024-07-24doi.org/10.1073/pnas.2403217121
8ZSJAAmineTrace AmineTA1Homo sapiens--chim(NtGi1L-Gs)/β1/γ22.82024-07-24doi.org/10.1016/j.celrep.2024.114505
8ZSPAAmineTrace AmineTA1Homo sapiensLSD-chim(NtGi1L-Gs)/β1/γ23.142024-07-24doi.org/10.1016/j.celrep.2024.114505
8ZSSAAmineTrace AmineTA1Homo sapiensRO5263397-chim(NtGi1-Gs)/β1/γ23.072024-07-24doi.org/10.1016/j.celrep.2024.114505
8ZSVAAmineTrace AmineTA1Mus musculusRO5263397-chim(NtGi1-Gs)/β1/γ22.962024-07-24doi.org/10.1016/j.celrep.2024.114505
8KGGANucleotideP2YP2Y10Homo sapiensLysophosphatidylserine (WJS)-chim(NtGi2-G13)/β1/γ23.062024-07-31doi.org/10.1016/j.chembiol.2024.08.005
8K6MAPeptideNeuropeptide YY1Homo sapiensNeuropeptide-Y-Gi2/β1/γ13.32024-07-31doi.org/10.1002/mco2.565
8K6OAPeptideNeuropeptide YY1Homo sapiensNeuropeptide-Y-Gi2/β1/γ13.32024-07-31doi.org/10.1002/mco2.565
8K6NAPeptideNeuropeptide YY2Homo sapiensNeuropeptide-Y-Gi2/β1/γ13.22024-07-31doi.org/10.1002/mco2.565
9IJDAAmineAdrenergicβ3Homo sapiensCarazolol-chim(NtGi1-Gs)/β1/γ22.762024-08-21doi.org/10.1002/cplu.202400288
9IJEAAmineAdrenergicβ3Homo sapiensEpinephrine-chim(NtGi1-Gs)/β1/γ22.342024-08-21doi.org/10.1002/cplu.202400288
8JJPAProteinChemerinCML2Homo sapiensChemerin-9-Gi1/β1/γ22.92024-08-21doi.org/10.1371/journal.pbio.3002838
8XGMAProteinChemerinCML2Homo sapiensChemerin-Gi1/β1/γ23.292024-08-21doi.org/10.1371/journal.pbio.3002838
8TZQAAmineDopamineD2Homo sapiensDopamine-Go/β1/γ23.22024-08-21doi.org/10.1038/s41467-024-50964-z
8U02AAmineDopamineD2Homo sapiensDopamine-Go/β1/γ23.282024-08-21doi.org/10.1038/s41467-024-50964-z
8XVIAPeptideEndothelinETAHomo sapiensEndothelin-1-chim(Gs-CtGq)/β1/γ23.322024-08-28doi.org/10.1038/s41421-024-00705-9
8XVEAPeptideEndothelinETBHomo sapiensBQ3020-chim(Gs-CtGq)/β1/γ232024-08-28doi.org/10.1038/s41421-024-00705-9
8XVHAPeptideEndothelinETBHomo sapiensEndothelin-1-chim(Gs-CtGq)/β1/γ23.262024-08-28doi.org/10.1038/s41421-024-00705-9
9CBLAAmineAdrenergicα2aHomo sapiensEpinephrine-Gi1/β1/γ22.82024-09-11doi.org/10.1038/s12276-024-01296-x
9CBMAAmineAdrenergicα2aHomo sapiensDexmedetomidine-Gi1/β1/γ23.22024-09-11doi.org/10.1038/s12276-024-01296-x
8Y52APeptideBombesinBB3Homo sapiensBA1-chim(NtGi1-Gs-CtGq)/β1/γ22.92024-09-11doi.org/10.1016/j.celrep.2024.114511
9BQJAPeptideOpioidμMus musculusRO76-Gi1/β1/γ23.32024-09-11doi.org/10.1021/acscentsci.4c00525
8WOGAAlicarboxylic acidSuccinateSuccinateHomo sapiensSuccinic acid-Gi1/β1/γ22.972024-09-11doi.org/10.1016/j.celrep.2024.114381
8WP1AAlicarboxylic acidSuccinateSuccinateHomo sapiensCis-Epoxysuccinic acid-Gi1/β1/γ23.152024-09-11doi.org/10.1016/j.celrep.2024.114381
9F33AAmineDopamineD3Homo sapiensFOB02-04A-Go/β1/γ23.052024-09-18doi.org/10.1038/s41467-024-51993-4
9F34AAmineDopamineD3Homo sapiensFOB02-04A-Go/β1/γ23.052024-09-18doi.org/10.1038/s41467-024-51993-4
8YW4B1PeptideGlucagonGIPHomo sapiensRetatrutide-chim(NtGi1-Gs)/β1/γ23.262024-09-18doi.org/10.1038/s41421-024-00700-0
8YW3B1PeptideGlucagonGLP-1Homo sapiensRetatrutide-Gs/β1/γ22.682024-09-18doi.org/10.1038/s41421-024-00700-0
8YW5B1PeptideGlucagonGlucagonHomo sapiensRetatrutide-Gs/β1/γ22.842024-09-18doi.org/10.1038/s41421-024-00700-0
8XORAPeptideProteinase ActivatedPAR1Homo sapiens--chim(NtGi1-Gs-CtGq)/β1/γ232024-09-18doi.org/10.1038/s41422-024-00997-2
8XOSAPeptideProteinase ActivatedPAR1Homo sapiens--Gi1/β1/γ23.22024-09-18doi.org/10.1038/s41422-024-00997-2
8QJ2APeptideMelanocortinMC4Homo sapienspN162-Gs/β1/γ23.42024-09-25doi.org/10.1038/s41467-024-50827-7
8ZPSAPeptideProlactin-Releasing PeptidePrRPHomo sapiensPrRP20-chim(NtGi1-Gs-CtGi1)/β1/γ22.972024-09-25doi.org/10.1038/s41421-024-00724-6
8ZPTAPeptideProlactin-Releasing PeptidePrRPHomo sapiensPrRP20-chim(NtGi1-Gs-CtGq)/β1/γ22.962024-09-25doi.org/10.1038/s41421-024-00724-6
8XWPAPeptideEndothelinETBHomo sapiensEndothelin-1-Gi1/β1/γ23.212024-10-02doi.org/10.1038/s42003-024-06905-z
8XWQAPeptideEndothelinETBHomo sapiensEndothelin-1-Gi1/β1/γ24.62024-10-02doi.org/10.1038/s42003-024-06905-z
9EW2FProteinFrizzledFZD7Homo sapiens--Gs/β1/γ23.22024-10-02doi.org/10.1038/s41467-024-51664-4
9IQTAAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiensNiacin-Gi1/β1/γ22.92024-10-02doi.org/10.1016/j.jmb.2024.168795
8WJXANucleotideP2YP2Y1Homo sapiensADP-chim(Gs-CtGq)/β1/γ23.22024-10-02To be published
9GYOASteroidBile acidGPBAHomo sapiensP395-chim(NtGi1-Gs)/β1/γ22.52024-10-09doi.org/10.1038/s41598-025-16529-w
8YN3AAmineHistamineH2Homo sapiensHistamine-Gs/β1/γ22.562024-10-09doi.org/10.1038/s41467-024-52585-y
8YN4AAmineHistamineH2Homo sapiensHistamine-chim(NtGi1L-Gs-CtGq)/β1/γ22.972024-10-09doi.org/10.1038/s41467-024-52585-y
8YN5AAmineHistamineH3Homo sapiensHistamine-Gi1/β1/γ22.72024-10-09doi.org/10.1038/s41467-024-52585-y
8YN6AAmineHistamineH3Homo sapiensImetit-Gi1/β1/γ22.772024-10-09doi.org/10.1038/s41467-024-52585-y
8YN9AAmineHistamineH4Homo sapiensHistamine-Gi1/β1/γ22.32024-10-09doi.org/10.1038/s41467-024-52585-y
8YN7AAmineHistamineH3Homo sapiensImmethridine-Go/β1/γ22.772024-10-16doi.org/10.2210/pdb8YN7/pdb
8YN8AAmineHistamineH3Homo sapiensProxyfan-Go/β1/γ22.772024-10-16doi.org/10.2210/pdb8YN7/pdb
8YNAAAmineHistamineH4Homo sapiensImmepip-Gi1/β1/γ22.632024-10-16doi.org/10.2210/pdb8YN7/pdb
9EPPASensoryOpsinsRhodopsinHasarius adansoni11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ24.062024-10-23doi.org/10.1038/s41467-024-53208-2
9EPQASensoryOpsinsRhodopsinHasarius adansoni11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ24.152024-10-23doi.org/10.1038/s41467-024-53208-2
8ZX4ALipidGPR55GPR55Homo sapiensLysophosphatidylinositol-chim(NtGi1-G13)/β1/γ23.032024-11-13doi.org/10.1038/s41422-024-01044-w
8ZX5ALipidGPR55GPR55Homo sapiensAM251-chim(NtGi1-G13)/β1/γ22.852024-11-13doi.org/10.1038/s41422-024-01044-w
9J5VALipidLysophospholipidLPA1Homo sapiensCpY-Gi1/β1/γ22.862024-11-27doi.org/10.1038/s42003-024-07152-y
9IYBALipidProstanoidDP2Homo sapiensPGD2A1D5QGi1/β1/γ22.822024-12-04doi.org/10.1073/pnas.2403304121
9DQHAOrphanOrphanMRGPRDHomo sapiensEP-2825-chim(NtGi1-Gs-CtGq)/β1/γ22.922024-12-11doi.org/10.1016/j.celrep.2024.114942
9DQJAOrphanOrphanMRGPRDHomo sapiensEP-3945-chim(NtGi1-Gs-CtGq)/β1/γ22.92024-12-11doi.org/10.1016/j.celrep.2024.114942
9IZFALipidLysophospholipidLPA1Homo sapiensLPA-Gi1/β1/γ23.142025-01-01doi.org/10.1016/j.jsb.2024.108164
9IZGALipidLysophospholipidLPA1Homo sapiensLPA-chim(NtGi1-Gs-CtGq)/β1/γ23.042025-01-01doi.org/10.1016/j.jsb.2024.108164
8XXZAProteinChemokineCXCR3Homo sapiens--Go/β1/γ23.32025-02-26doi.org/10.1038/s41467-025-58264-w
8XYKAProteinChemokineCXCR3Homo sapiensVUF10661-Go/β1/γ23.032025-02-26doi.org/10.1038/s41467-025-58264-w
8Y0NAProteinChemokineCXCR3Homo sapiensVUF11418-Go/β1/γ23.072025-02-26doi.org/10.1038/s41467-025-58264-w
9J1PB1PeptideGlucagonGLP-1Homo sapiensg1:Ox-chim(NtGi1-Gs)/β1/γ22.992025-02-26doi.org/10.1021/jacs.4c12808
8UTDAAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensMK1903-Gi1/β1/γ23.242025-02-26doi.org/10.1016/j.cell.2024.11.001
8UUJAAlicarboxylic acidHydroxycarboxylic AcidHCA2Mus musculusFCH-2296413-Gi1/β1/γ22.622025-02-26doi.org/10.1016/j.cell.2024.11.001
9B54ALipidCannabinoidCB1Homo sapiensVIP36-Gi1/β1/γ22.862025-03-05doi.org/10.1038/s41586-025-08618-7
9B65ALipidCannabinoidCB1Homo sapiensMDMB-Fubinaca-Gi1/β1/γ23.032025-03-05doi.org/10.1038/s41586-025-08618-7
9U9VAAmineAdrenergicβ2Homo sapiensMETH-Gs/β1/γ22.852025-09-03To be published
9E9SALipidProstanoidDP1Homo sapiensPGD2-Gs/β1/γ12.682025-09-03To be published
9EJCAOtherUclassifiedORF74Human gammaherpesvirus 8CXCL1-Gi1/β1/γ22.982025-09-03doi.org/10.1038/s41467-025-63457-4
9JEDAAmineHistamineH4Homo sapiensHistaminePO4Gi1/β1/γ22.582025-09-10doi.org/10.1038/s41401-025-01633-4
9JCLANucleotideP2YP2Y1Homo sapiensADP-chim(Gs-CtGq)/β1/γ22.762025-09-10To be published
9BSBAAmineDopamineD2Homo sapiensLSD-chim(NtGi1-Go)/β1/γ22.322025-09-17doi.org/10.1016/j.neuron.2025.06.012
9M8VAOrphanOrphanGPR3 ; GPR3Homo sapiens-AF64394chim(NtGi1-Gs)/β1/γ23.832025-09-24doi.org/10.1038/s41467-025-63422-1
9JEQAAmineHistamineH3Homo sapiensHistamine-Gi1/β1/γ23.052025-09-24doi.org/10.1038/s41401-025-01633-4
9JLCAOrphanOrphanMAS1Homo sapiensAVE 0991-Gi1/β1/γ22.982025-09-24To be published
9EK0AAmineAcetylcholine (muscarinic)M5Homo sapiensIperoxo-chim(NtGi1-Gs-CtGq)/β1/γ22.792025-10-08doi.org/10.1038/s41467-025-62212-z
9JR0CAminoacidGABABGABAB2; GABAB1Drosophila melanogasterGABA-Gi1/β1/γ23.062025-10-22To be published
9L42AAmineHistamineH4Homo sapiensHistamine-Gi1/β1/γ22.92025-10-22doi.org/10.3390/ph18030292
9JKYAAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensAcifran-Gi1/β1/γ22.722025-10-29To be published
9JKSAAlicarboxylic acidHydroxycarboxylic AcidHCA3Homo sapiensPubChem 44250176-Gi1/β1/γ23.312025-10-29To be published
9JKTAAlicarboxylic acidHydroxycarboxylic AcidHCA3Homo sapiens(2R)-2-hydroxy-3-phenylpropanoic acid-Gi1/β1/γ23.052025-10-29To be published
9JKVAAlicarboxylic acidHydroxycarboxylic AcidHCA3Homo sapiensPubChem 2736690-Gi1/β1/γ23.262025-10-29To be published
9JKXAAlicarboxylic acidHydroxycarboxylic AcidHCA3Homo sapiensAcifran-Gi1/β1/γ23.182025-10-29To be published
9KVPAPeptideComplement PeptideC3aBHomo sapiensSB290157-Go/β1/γ22.792025-11-2610.1101/2025.05.26.656101
9KZ2APeptideComplement PeptideC3aBHomo sapiensEP67-Go/β1/γ23.432025-11-2610.1101/2025.05.26.656101
9KZ8APeptideComplement PeptideC3aBMus musculusEP67-Go/β1/γ23.32025-11-2610.1101/2025.05.26.656101
9KZKAPeptideComplement PeptideC3aBMus musculusC3a (fragment)-Go/β1/γ23.542025-11-2610.1101/2025.05.26.656101
9L0HAPeptideComplement PeptideC3aBMus musculusJR14a-Go/β1/γ23.572025-11-2610.1101/2025.05.26.656101
9UMJAPeptideComplement PeptideC3aBMus musculusEP54-Go/β1/γ23.382025-11-2610.1101/2025.05.26.656101
9KWGAPeptideComplement PeptideC5a1Mus musculusC5a-Go/β1/γ23.152025-11-2610.1101/2025.05.26.656101
9KWXAPeptideComplement PeptideC5a1Mus musculusC5a-des-Arg-Go/β1/γ23.132025-11-2610.1101/2025.05.26.656101
9KX6APeptideComplement PeptideC5a1Mus musculusC5a-des-Arg-Go/β1/γ23.112025-11-2610.1101/2025.05.26.656101
9KXSAPeptideComplement PeptideC5a1Mus musculusEP67-Go/β1/γ23.312025-11-2610.1101/2025.05.26.656101
9UMRAPeptideComplement PeptideC5a1Homo sapiensC5a-pep-Go/β1/γ23.152025-11-2610.1101/2025.05.26.656101
9UMXAPeptideComplement PeptideC5a1Homo sapiensEP54-Go/β1/γ23.22025-11-2610.1101/2025.05.26.656101
9WSTAPeptideOpioidμHomo sapiensDAMGO-chim(NtGi1-Gz)/β1/γ22.82025-11-2610.1038/s41422-025-01191-8
9WSWAPeptideOpioidμHomo sapiensEndomorphin-chim(NtGi1-Gz)/β1/γ22.82025-11-2610.1038/s41422-025-01191-8
9L74ALipidLysophospholipidS1P3Homo sapiensS1P d16:1-chim(NtGi2L-Gs-CtGq)/β1/γ23.732025-11-2610.1073/pnas.2507421122
9WP9ALipidLysophospholipidS1P3Homo sapiensS1P-chim(NtGi2L-Gs-CtGq)/β1/γ23.252025-11-2610.1073/pnas.2507421122
7RKYAOtherUnclassifiedUS27Human betaherpesvirus 5-GDPGi1/β1/γ23.82022-01-26doi.org/10.1126/sciadv.abl5442
7T10APeptideSomatostatinSST2Homo sapiensSomatostatin-14-Gi3/β1/γ22.52022-03-09doi.org/10.1038/s41594-022-00727-5
7T11APeptideSomatostatinSST2Homo sapiensOctreotide-Gi3/β1/γ22.72022-03-09doi.org/10.1038/s41594-022-00727-5
7T96AAmineAcetylcholine (muscarinic)M2Homo sapiensAcetylcholineLY2119620Go/β1/γ23.222023-01-25doi.org/10.1038/s41467-022-35726-z
8PM2AAmineTrace AmineTA7Mus musculusDMCHA-Gs/β1/γ22.922023-08-09doi.org/10.1101/2023.07.07.547762
8IA7APeptideCholecystokininCCKBHomo sapiensCholecystokinin-8-chim(NtGi1L-Gq)/β1/γ23.12023-12-06doi.org/10.1038/s41421-022-00420-3
8J6PAAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensNiacinPubChem 25101223Gi1/β1/γ22.552023-12-06doi.org/10.1038/s41467-023-43537-z
8J6QAAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensβ-HydroxybutyratePubChem 25101223Gi1/β1/γ22.62023-12-06doi.org/10.1038/s41467-023-43537-z
8J6RAAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensMK6892-Gi1/β1/γ22.762023-12-06doi.org/10.1038/s41467-023-43537-z
8FEGAPeptideOpioidκHomo sapiens(DNCP)-β-Naloxamine-Gi1/β1/γ22.542023-12-06doi.org/10.1038/s41467-023-43718-w
8U1UAProteinChemokineCCR8Homo sapiensCCL1-Gi1/β1/γ23.12023-12-20doi.org/10.1038/s41467-023-43601-8
8XBHAOrphanOrphanGPR34Homo sapiensPubChem 162656636-Gi1/β1/γ22.832023-12-27doi.org/10.1038/s41467-024-45046-z
8WC3AAmineTrace AmineTA1Mus musculusSEP-363856-chim(NtGi1-Gs)/β1/γ232023-12-27doi.org/10.1016/j.cell.2023.10.014
8WC4AAmineTrace AmineTA1Mus musculusZH8651-chim(NtGi1-Gs)/β1/γ23.12023-12-27doi.org/10.1016/j.cell.2023.10.014
8WC5AAmineTrace AmineTA1Mus musculusTetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ23.32023-12-27doi.org/10.1016/j.cell.2023.10.014
8WC6AAmineTrace AmineTA1Mus musculus2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ23.22023-12-27doi.org/10.1016/j.cell.2023.10.014
8WC7AAmineTrace AmineTA1Mus musculusZH8667-chim(NtGi1-Gs)/β1/γ23.12023-12-27doi.org/10.1016/j.cell.2023.10.014
8WC8AAmineTrace AmineTA1Homo sapiensZH8651-chim(NtGi1-Gs)/β1/γ22.92023-12-27doi.org/10.1016/j.cell.2023.10.014
8WC9AAmineTrace AmineTA1Mus musculusZH8651-chim(NtGi1-Gs-CtGq)/β1/γ23.22023-12-27doi.org/10.1016/j.cell.2023.10.014
8WCAAAmineTrace AmineTA1Homo sapiens2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ23.482023-12-27doi.org/10.1016/j.cell.2023.10.014
8WCBAAmineTrace AmineTA1Mus musculusCyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ23.12023-12-27doi.org/10.1016/j.cell.2023.10.014
8W8QAOrphanOrphanGPR101Homo sapiens--Gs/β1/γ22.892024-01-03doi.org/10.1038/s41589-023-01456-6
8W8RAOrphanOrphanGPR101Homo sapiens-AA-14chim(NtGi1-Gs)/β1/γ23.32024-01-03doi.org/10.1038/s41589-023-01456-6
8J6JAAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensGSK256073-Gi1/β1/γ22.82024-01-10doi.org/10.1016/j.celrep.2023.113406
8JGBAOrphanOrphanMRGPRX1Homo sapiensConorfamide-Tx2-Gi1/β1/γ22.842024-01-10doi.org/10.1038/s41467-023-40705-z
8JGFAOrphanOrphanMRGPRX1Homo sapiensBAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ22.72024-01-10doi.org/10.1038/s41467-023-40705-z
8JGGAOrphanOrphanMRGPRX1Homo sapiensBAM8-22-Gi1/β1/γ232024-01-10doi.org/10.1038/s41467-023-40705-z
8UHBAAmineTrace AmineTA1Homo sapiensRO5256390-Gs/β1/γ23.352024-01-10doi.org/10.1038/s41467-023-44601-4
8T3OALipidFree Fatty AcidFFA4Homo sapiensTUG-891-chim(NtGi2L-Gs-CtGq)/β1/γ23.062024-01-17doi.org/10.1126/sciadv.adj2384
8J9NFProteinFrizzledFZD1Homo sapiens--chim(Gs-CtGq)/β1/γ23.52024-01-17doi.org/10.1038/s41421-023-00627-y
8JHIFProteinFrizzledFZD3Homo sapiens--chim(NtGsXLas-Gs)/β1/γ23.22024-01-17doi.org/10.1038/s41421-023-00627-y
8JHBFProteinFrizzledFZD6Homo sapiens--chim(NtGsXLas-Gs)/β1/γ23.32024-01-17doi.org/10.1038/s41421-023-00627-y
8IKLB2AdhesionAdhesionADGRE5Homo sapiens--chim(NtGi1L-G13)/β1/γ22.332024-01-24doi.org/10.1016/j.molcel.2023.12.020
8T3VALipidFree Fatty AcidFFA1Homo sapiensDoconexent-chim(NtGi2L-Gs-CtGq)/β1/γ23.392024-01-24doi.org/10.1126/sciadv.adj2384
8J22ALipidFree Fatty AcidFFA2Homo sapiensTUG-1375-Gi1/β1/γ23.22024-01-24doi.org/10.1038/s41422-023-00914-z
8J24ALipidFree Fatty AcidFFA2Homo sapiensAcetic acid-Gi1/β1/γ22.62024-01-24doi.org/10.1038/s41422-023-00914-z
8T3SALipidFree Fatty AcidFFA2Homo sapiensButyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ23.072024-01-24doi.org/10.1126/sciadv.adj2384
8J20ALipidFree Fatty AcidFFA3Homo sapiensValeric acidAR420626Gi1/β1/γ23.22024-01-24doi.org/10.1038/s41422-023-00914-z
8J21ALipidFree Fatty AcidFFA3Homo sapiensButyric acid-Gi1/β1/γ23.32024-01-24doi.org/10.1038/s41422-023-00914-z
8T3QALipidFree Fatty AcidFFA4Homo sapiensDoconexent-chim(NtGi2L-Gs-CtGq)/β1/γ23.142024-01-24doi.org/10.1126/sciadv.adj2384
8IQ4ALipidProstanoidFP-alphaHomo sapiensCarboprost-chim(NtGi1-Gs-CtGq)/β1/γ22.72024-01-31doi.org/10.1038/s41467-023-43922-8
8IQ6ALipidProstanoidFP-alphaHomo sapiensLatanoprost-chim(NtGi1-Gs-CtGq)/β1/γ23.42024-01-31doi.org/10.1038/s41467-023-43922-8
8SZGCIonCalcium SensingCaS; CaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4; Sperminechim(NtGi1-Gq)/β1/γ23.62024-02-07doi.org/10.1038/s41586-024-07055-2
8SZHCIonCalcium SensingCaS; CaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4; SpermineGi1/β1/γ23.12024-02-07doi.org/10.1038/s41586-024-07055-2
8SZICIonCalcium SensingCaS; CaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4Gi3/β1/γ23.52024-02-07doi.org/10.1038/s41586-024-07055-2
8KFXAProteinChemokineCCR8Homo sapiensLMD-009-Gi1/β1/γ22.962024-02-07doi.org/10.1126/sciadv.adj7500
8KFYAProteinChemokineCCR8Homo sapiensZK-756326-Gi1/β1/γ23.062024-02-07doi.org/10.1126/sciadv.adj7500
8KFZAProteinChemokineCCR8Homo sapiens--Gi1/β1/γ23.32024-02-07doi.org/10.1126/sciadv.adj7500
8I7VAAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensAcipimox-Gi1/β1/γ22.772024-02-07doi.org/10.1038/s41467-023-42764-8
8I7WAAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensGSK256073-Gi1/β1/γ23.392024-02-07doi.org/10.1038/s41467-023-42764-8
8JBGAPeptideTachykininNK3Homo sapiensNeurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ22.82024-02-07doi.org/10.1038/s41421-023-00564-w
8JBHAPeptideTachykininNK3Homo sapiensSubstance-P-chim(NtGi1-Gs-CtGq)/β1/γ22.92024-02-07doi.org/10.1038/s41421-023-00564-w
8K8JALipidCannabinoidCB1Homo sapiensFenofibrate-chim(Gs-CtGq)/β1/γ22.882024-02-14doi.org/10.1002/advs.202306311
8IEDCOrphanOrphanGPR156; GPR156Homo sapiensPubChem 134746894-Go/β1/γ23.332024-02-14doi.org/10.1038/s41594-024-01224-7
8WW2AOrphanOrphanGPR3Homo sapiens--chim(NtGi1-Gs)/β1/γ22.792024-02-14doi.org/10.1038/s41422-024-00932-5
8SMVAOrphanOrphanGPR161Homo sapiens--Gs/β1/γ22.742024-02-21doi.org/10.1038/s41594-024-01223-8
8JT6AAmine5-Hydroxytryptamine5-HT1AHomo sapiens(R)-IHCH-7179PtdIns4PGi1/β1/γ232024-02-28doi.org/10.1016/j.cell.2024.02.034
8GAGALipidCannabinoidCB1Homo sapiensZ8526711350-Gi1/β1/γ23.32024-02-28To be published
8XJKALipidProstanoidFP-alphaHomo sapiensCloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ22.632024-02-28doi.org/10.1016/j.celrep.2024.113893
8XJLALipidProstanoidFP-alphaHomo sapiensPGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ22.772024-02-28doi.org/10.1016/j.celrep.2024.113893
8XJMALipidProstanoidFP-alphaHomo sapiensLatanoprost-chim(NtGi2-Gs-CtGq)/β1/γ22.852024-02-28doi.org/10.1016/j.celrep.2024.113893
8JBFAPeptideTachykininNK3Homo sapiensSenktide-chim(NtGi1-Gs-CtGq)/β1/γ232024-02-28doi.org/10.1038/s41421-023-00564-w
8XJNALipidProstanoidTXA2Homo sapiensCloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ23.062024-02-28doi.org/10.1016/j.celrep.2024.113893
8XJOALipidProstanoidTXA2Homo sapiensU46619-chim(NtGi1-Gs-CtGq)/β1/γ23.112024-02-28doi.org/10.1016/j.celrep.2024.113893
8GDZAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GE1AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.42024-03-06doi.org/10.1038/s41586-024-07153-1
8GE3AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.32024-03-06doi.org/10.1038/s41586-024-07153-1
8GE4AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.32024-03-06doi.org/10.1038/s41586-024-07153-1
8GE6AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.42024-03-06doi.org/10.1038/s41586-024-07153-1
8GE7AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.42024-03-06doi.org/10.1038/s41586-024-07153-1
8GE8AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.42024-03-06doi.org/10.1038/s41586-024-07153-1
8GE9AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GEAAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GEBAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.62024-03-06doi.org/10.1038/s41586-024-07153-1
8GECAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GEDAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GEEAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.72024-03-06doi.org/10.1038/s41586-024-07153-1
8GEFAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.82024-03-06doi.org/10.1038/s41586-024-07153-1
8GEGAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.82024-03-06doi.org/10.1038/s41586-024-07153-1
8GEHAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ242024-03-06doi.org/10.1038/s41586-024-07153-1
8GEIAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ24.12024-03-06doi.org/10.1038/s41586-024-07153-1
8GEJAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ24.22024-03-06doi.org/10.1038/s41586-024-07153-1
8GFVAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.12024-03-06doi.org/10.1038/s41586-024-07153-1
8GFWAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ232024-03-06doi.org/10.1038/s41586-024-07153-1
8GFXAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ232024-03-06doi.org/10.1038/s41586-024-07153-1
8GFYAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ232024-03-06doi.org/10.1038/s41586-024-07153-1
8GFZAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ232024-03-06doi.org/10.1038/s41586-024-07153-1
8GG0AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ22.92024-03-06doi.org/10.1038/s41586-024-07153-1
8GG1AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ232024-03-06doi.org/10.1038/s41586-024-07153-1
8GG2AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ232024-03-06doi.org/10.1038/s41586-024-07153-1
8GG3AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.12024-03-06doi.org/10.1038/s41586-024-07153-1
8GG4AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.22024-03-06doi.org/10.1038/s41586-024-07153-1
8GG5AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.22024-03-06doi.org/10.1038/s41586-024-07153-1
8GG6AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.32024-03-06doi.org/10.1038/s41586-024-07153-1
8GG7AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.32024-03-06doi.org/10.1038/s41586-024-07153-1
8GG8AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.32024-03-06doi.org/10.1038/s41586-024-07153-1
8GG9AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.42024-03-06doi.org/10.1038/s41586-024-07153-1
8GGAAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GGBAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GGCAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.42024-03-06doi.org/10.1038/s41586-024-07153-1
8GGEAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GGFAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.62024-03-06doi.org/10.1038/s41586-024-07153-1
8UNLAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.32024-03-06doi.org/10.1038/s41586-024-07153-1
8UNMAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.42024-03-06doi.org/10.1038/s41586-024-07153-1
8UNNAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.42024-03-06doi.org/10.1038/s41586-024-07153-1
8UNOAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.32024-03-06doi.org/10.1038/s41586-024-07153-1
8UNPAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.32024-03-06doi.org/10.1038/s41586-024-07153-1
8UNQAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.32024-03-06doi.org/10.1038/s41586-024-07153-1
8UNRAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.42024-03-06doi.org/10.1038/s41586-024-07153-1
8UNSAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.42024-03-06doi.org/10.1038/s41586-024-07153-1
8UNTAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.42024-03-06doi.org/10.1038/s41586-024-07153-1
8UNUAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.52024-03-06doi.org/10.1038/s41586-024-07153-1
8UNVAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.32024-03-06doi.org/10.1038/s41586-024-07153-1
8UNWAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.42024-03-06doi.org/10.1038/s41586-024-07153-1
8UNXAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.62024-03-06doi.org/10.1038/s41586-024-07153-1
8UNYAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.62024-03-06doi.org/10.1038/s41586-024-07153-1
8UNZAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.82024-03-06doi.org/10.1038/s41586-024-07153-1
8UO0AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.52024-03-06doi.org/10.1038/s41586-024-07153-1
8UO1AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP; MgGs/β1/γ23.62024-03-06doi.org/10.1038/s41586-024-07153-1
8UO2AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.62024-03-06doi.org/10.1038/s41586-024-07153-1
8UO3AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP; MgGs/β1/γ23.52024-03-06doi.org/10.1038/s41586-024-07153-1
8UO4AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP; MgGs/β1/γ242024-03-06doi.org/10.1038/s41586-024-07153-1
8WA3B1PeptideGlucagonGIPHomo sapiens--Gs/β1/γ22.862024-03-06doi.org/10.1038/s41421-024-00649-0
8WG7B1PeptideGlucagonGLP-1Homo sapiens--Gs/β1/γ22.542024-03-06doi.org/10.1038/s41421-024-00649-0
8WG8B1PeptideGlucagonGlucagonHomo sapiens-Peptidechim(NtGi1-Gs)/β1/γ22.712024-03-06doi.org/10.1038/s41421-024-00649-0
8U8FAOrphanOrphanGPR3Homo sapiensPalmitic Acid-Gs/β1/γ23.492024-03-06doi.org/10.1021/acs.biochem.3c00647
8POKAAmineHistamineH2Homo sapiensHistamine-Gs/β1/γ23.42024-03-06doi.org/10.1038/s41467-024-46096-z
8IY9AAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensNiacin-Go/β1/γ23.372024-03-06doi.org/10.1038/s41467-024-46239-2
8IYHAAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensMK6892-Go/β1/γ23.32024-03-06doi.org/10.1038/s41467-024-46239-2
8IYWAAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensGSK256073-Go/β1/γ23.452024-03-06doi.org/10.1038/s41467-024-46239-2
8JERAAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensAcipimox-Go/β1/γ23.452024-03-06doi.org/10.1038/s41467-024-46239-2
8JHNAAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensMonomethyl fumarate-Go/β1/γ23.752024-03-06doi.org/10.1038/s41467-024-46239-2
8X79ALipidProstanoidI2Homo sapiensMRE-269-Gs/β1/γ22.412024-03-06doi.org/10.1126/sciadv.adk5184
8X7AALipidProstanoidI2Homo sapiensTreprostinil-Gs/β1/γ22.562024-03-06doi.org/10.1126/sciadv.adk5184
8U4NAProteinChemokineCXCR4Homo sapiens--Gi1/β1/γ22.722024-03-13doi.org/10.1101/2024.02.09.579708
8U4OAProteinChemokineCXCR4Homo sapiensCXCL12-Gi1/β1/γ23.292024-03-13doi.org/10.1101/2024.02.09.579708
8U4PAProteinChemokineCXCR4Homo sapiensAMD3100-Gi1/β1/γ23.152024-03-13doi.org/10.1101/2024.02.09.579708
8U4QAProteinChemokineCXCR4Homo sapiensREGN7663-Fab-Gi1/β1/γ23.362024-03-13doi.org/10.1101/2024.02.09.579708
8XZFAPeptideApelinApelin; ApelinHomo sapiensWN561-Gi1/β1/γ232024-03-20doi.org/10.1016/j.cell.2024.02.004
8XZGAPeptideApelinApelin; ApelinHomo sapiensApelin-13-Gi1/β1/γ23.22024-03-20doi.org/10.1016/j.cell.2024.02.004
8XZHAPeptideApelinApelin; ApelinHomo sapiensMM07-Gi1/β1/γ22.062024-03-20doi.org/10.1016/j.cell.2024.02.004
8XZIAPeptideApelinApelin; ApelinHomo sapiensCMF-019-Gi1/β1/γ22.72024-03-20doi.org/10.1016/j.cell.2024.02.004
8XZJAPeptideApelinApelin; ApelinHomo sapiensWN353-Gi1/β1/γ232024-03-20doi.org/10.1016/j.cell.2024.02.004
8JXTAAmineHistamineH4Homo sapiensHistaminePO4Gi1/β1/γ23.072024-03-20doi.org/10.1038/s41467-024-46840-5
8JXVAAmineHistamineH4Homo sapiensClozapine-Gi1/β1/γ23.212024-03-20doi.org/10.1038/s41467-024-46840-5
8JXWAAmineHistamineH4Homo sapiensVUF6884-Gi1/β1/γ23.012024-03-20doi.org/10.1038/s41467-024-46840-5
8JXXAAmineHistamineH4Homo sapiensClobenpropit-Gi1/β1/γ23.062024-03-20doi.org/10.1038/s41467-024-46840-5
8IU2ASensoryOpsinsOpsin1LWHomo sapiensAll-trans-Retinal-Gi1/β1/γ23.352024-03-27To be published
8X2KAOrphanOrphanGPR3Homo sapiensOleic monoethanolamide-chim(NtGi1-Gs)/β1/γ23.032024-04-03doi.org/10.1038/s41422-023-00919-8
8J6IAAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensMK6892-Gi1/β1/γ22.922024-04-03doi.org/10.1016/j.celrep.2023.113406
8J6LAAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensNiacin-Gi1/β1/γ23.052024-04-03doi.org/10.1016/j.celrep.2023.113406
8XOFAOrphanOrphanGPR30Homo sapiensLys05-chim(NtGi1-Gs-CtGq)/β1/γ22.62024-04-10doi.org/10.1038/s41422-024-00963-y
8XOGAOrphanOrphanGPR30Homo sapiens--chim(NtGi1-Gs-CtGq)/β1/γ22.92024-04-10doi.org/10.1038/s41422-024-00963-y
8XOHAOrphanOrphanGPR30Homo sapiens--chim(NtGi1-Gs-CtGq)/β1/γ23.22024-04-10doi.org/10.1038/s41422-024-00963-y
8XOIAOrphanOrphanGPR30Homo sapiens--chim(NtGi1-Gs-CtGq)/β1/γ23.22024-04-10doi.org/10.1038/s41422-024-00963-y
8XOJAOrphanOrphanGPR30Homo sapiens--chim(NtGi1-Gs-CtGq)/β1/γ23.12024-04-10doi.org/10.1038/s41422-024-00963-y
8IZ4AOrphanOrphanGPR34Homo sapiensLysophosphatidylserine (TJR)-Gi1/β1/γ22.942024-04-10To be published
9AXFCIonCalcium SensingCaS; CaSHomo sapiensCaCa; Ca; Ca; Cyclomethyltryptophan; R-568; PO4chim(NtGi1-Gs-CtGq)/β1/γ23.52024-04-17doi.org/10.1038/s41586-024-07331-1
9AYFCIonCalcium SensingCaS; CaSHomo sapiensCaCa; Ca; Ca; Cyclomethyltryptophan; R-568; PO4Gi1/β1/γ23.62024-04-17doi.org/10.1038/s41586-024-07331-1
8J23ALipidFree Fatty AcidFFA2Homo sapiens--Gi1/β1/γ23.22024-04-17To be published
8X16ANucleotideAdenosineA3AHomo sapiensPiclidenoson-Gi1/β1/γ23.292024-04-24doi.org/10.1038/s41467-024-47207-6
8X17ANucleotideAdenosineA3AHomo sapiensNamodenoson-Gi1/β1/γ23.192024-04-24doi.org/10.1038/s41467-024-47207-6
9AUCB1PeptideCalcitoninCT (AMY1)Homo sapiensCalcitonin gene-related peptide-1-Gs/β1/γ2; RAMP12.42024-04-24doi.org/10.1021/acs.biochem.4c00114
8YY8FProteinFrizzledFZD7Homo sapiens--Gs/β1/γ23.222024-04-24doi.org/10.1038/s41422-021-00525-6
8YKVAAlicarboxylic acidSuccinateSuccinateHomo sapiensPubChem 137553168-Gi1/β1/γ22.482024-05-29doi.org/10.1038/s41422-024-00984-7
8XIOAPeptideSomatostatinSST1Homo sapiensL797591-chim(NtGi1-Gs-CtGi1)/β1/γ22.652024-07-03doi.org/10.1073/pnas.2400298121
8XIPAPeptideSomatostatinSST1Homo sapiensPasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ23.292024-07-03doi.org/10.1073/pnas.2400298121
8XIQAPeptideSomatostatinSST3Homo sapiensL796778-chim(NtGi1-Gs-CtGi1)/β1/γ22.712024-07-03doi.org/10.1073/pnas.2400298121
8XIRAPeptideSomatostatinSST3Homo sapiensPasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ22.522024-07-03doi.org/10.1073/pnas.2400298121
8Y53APeptideBombesinBB3Homo sapiensMK5046-chim(NtGi1-Gs-CtGq)/β1/γ22.932024-09-11doi.org/10.1016/j.celrep.2024.114511
8YN2AAmineHistamineH1Homo sapiensHistamine-chim(NtGi1L-Gs-CtGq)/β1/γ22.662024-10-09doi.org/10.1038/s41467-024-52585-y
9JR2B1PeptideParathyroid HormonePTH1Homo sapiensPTH-chim(NtGi1L-Gs-CtGq)/β1/γ22.82024-10-16doi.org/10.1038/s41589-025-01957-6
9JR3B1PeptideParathyroid HormonePTH1Homo sapiensPTH-chim(NtGi1L-Gs-CtGq)/β1/γ22.82024-10-16doi.org/10.1038/s41589-025-01957-6
9JKQAAmineTrace AmineTA1Homo sapiensMETH-Gs/β1/γ22.662024-10-16doi.org/10.1021/acs.jmedchem.4c01961
8UXYO2OdorantOdorant family 1consOR1Homo sapiensMenthol-Gs/β1/γ23.32024-10-30doi.org/10.1038/s41586-024-08126-0
8UY0O2OdorantOdorant family 2consOR2Homo sapiensCarvone-Gs/β1/γ23.22024-10-30doi.org/10.1038/s41586-024-08126-0
8UYQO2OdorantOdorant family 4consOR4Homo sapiens2-Methylthiazoline-Gs/β1/γ23.52024-10-30doi.org/10.1038/s41586-024-08126-0
8UXVO1OdorantOdorant family 51consOR51Homo sapiens--Gs/β1/γ23.22024-10-30doi.org/10.1038/s41586-024-08126-0
8VHFALipidGPR119GPR119Homo sapiensMBX-2982-Gs/β1/γ23.512024-10-30doi.org/10.1016/j.str.2024.10.004
8XGOAPeptideKisspeptinKiss1Homo sapiensTAK448-chim(NtGi1-Gq)/β1/γ22.682024-10-30doi.org/10.1126/sciadv.adn7771
8XGSAPeptideKisspeptinKiss1Homo sapiensKisspeptin-1-chim(NtGi1-Gq)/β1/γ22.952024-10-30doi.org/10.1126/sciadv.adn7771
8XGUAPeptideKisspeptinKiss1Homo sapiensTAK448-Gi1/β1/γ232024-10-30doi.org/10.1126/sciadv.adn7771
8WGBCAminoacidMetabotropic GlutamatemGlu4; mGlu2Homo sapiensGlutamateVU0155041Gi3/β1/γ23.72024-10-30doi.org/10.1038/s41467-024-54744-7
9EPRASensoryOpsinsRhodopsinHasarius adansoniAll-trans-Retinal-Gi1/β1/γ24.92024-10-30doi.org/10.1038/s41467-024-53208-2
8YH0ANucleotideAdenosineA3AHomo sapiensNECA-Gi1/β1/γ22.862024-11-06doi.org/10.1038/s41467-024-53473-1
8YH2ANucleotideAdenosineA3AHomo sapiensAdenosine-Gi1/β1/γ23.272024-11-06doi.org/10.1038/s41467-024-53473-1
8YH3ANucleotideAdenosineA3AHomo sapiensN-methyladenosine-Gi1/β1/γ23.42024-11-06doi.org/10.1038/s41467-024-53473-1
8YH5ANucleotideAdenosineA3AHomo sapiensRiboprine-Gi1/β1/γ23.662024-11-06doi.org/10.1038/s41467-024-53473-1
8YH6ANucleotideAdenosineA3AHomo sapiensNamodenoson-Gi1/β1/γ23.622024-11-06doi.org/10.1038/s41467-024-53473-1
8K4SAOrphanOrphanMRGPRX4Homo sapiensDCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ22.92024-11-06doi.org/10.1016/j.cell.2024.10.001
9IVMB1PeptideGlucagonGLP-1Homo sapiensGLP-1 (Truncated)LSN3318839chim(NtGi1-Gs)/β2/γ23.222024-11-13doi.org/10.1016/j.apsb.2024.09.002
8WWHAPeptideMelanin Concentrating HormoneMCH1Homo sapiens--Gi1/β1/γ22.842024-11-13To be published
8WWIAPeptideMelanin Concentrating HormoneMCH1Homo sapiens--Gi1/β1/γ23.432024-11-13To be published
8WWJAPeptideMelanin Concentrating HormoneMCH1Homo sapiens--Gi1/β1/γ23.032024-11-13To be published
8WWKAPeptideMelanin Concentrating HormoneMCH1Homo sapiensMCH-Gi1/β1/γ22.612024-11-13doi.org/10.1038/s41421-024-00754-0
8WWLAPeptideMelanin Concentrating HormoneMCH1Homo sapiensMCH-Gi1/β1/γ22.782024-11-13doi.org/10.1038/s41421-024-00754-0
8WWMAPeptideMelanin Concentrating HormoneMCH1Homo sapiensMCH-Gi1/β1/γ22.812024-11-13doi.org/10.1038/s41421-024-00754-0
8WWNAPeptideMelanin Concentrating HormoneMCH1Homo sapiensMCH-Gi1/β1/γ22.652024-11-13doi.org/10.1038/s41421-024-00754-0
8XYDALipidPlatelet Activating FactorPAFHomo sapiensPlatelet Activating Factor-Gi1/β1/γ22.92024-11-13doi.org/10.1016/j.celrep.2024.114422
8X3LALipidCannabinoidCB2Homo sapiensXWD-Gi1/β1/γ23.132024-11-20doi.org/10.1073/pnas.2401091121
8JEIAAlicarboxylic acidHydroxycarboxylic AcidHCAR3Homo sapiensPubChem 11715556-Gi1/β1/γ22.732024-11-20doi.org/10.2210/pdb8JEI/pdb
8P12ASensoryOpsinsRhodopsinBos taurus--Gi1/β1/γT13.212024-11-20To be published
8P13ASensoryOpsinsRhodopsinBos taurus--Gi1/β1/γT15.22024-11-20To be published
8P15ASensoryOpsinsRhodopsinBos taurus--Gi1/β1/γT15.92024-11-20To be published
8Y45APeptideOpioidδHomo sapiensADL5859-Gi2/β1/γ23.452024-11-27doi.org/10.1038/s41467-024-52601-1
9IVGB1PeptideGlucagonGLP-1Homo sapiensGLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ232024-11-27doi.org/10.1016/j.apsb.2024.09.002
8RQLT2SensoryTaste2TAS2R14Homo sapiensFlufenamic acidFlufenamic acidchim(NtGi1-Gt3)/β1/γ23.032024-11-27doi.org/10.1038/s41467-024-54157-6
8XXUALipidProstanoidDP2Homo sapiens-A1D5QGi1/β1/γ22.542024-12-04doi.org/10.1073/pnas.2403304121
8XXVALipidProstanoidDP2Homo sapiensIndomethacinA1D5QGi1/β1/γ22.332024-12-04doi.org/10.1073/pnas.2403304121
8TYWAOrphanOrphanGPR6Homo sapiens--Gs/β1/γ23.432024-12-04doi.org/10.2210/pdb8TF5/pdb
9K1CALipidFree Fatty AcidFFA1Homo sapiens-DoconexentGi1/β1/γ23.22024-12-11doi.org/10.1016/j.celrep.2024.115024
9K1DALipidFree Fatty AcidFFA2Homo sapiensButyric acid-Gi1/β1/γ23.342024-12-11doi.org/10.1016/j.celrep.2024.115024
8YICALipidLysophospholipidS1P1Homo sapiensSAR247799-Gi1/β1/γ23.472024-12-11To be published
9ASTAProteinChemokineXCR1Homo sapiensLymphotactin-Gi1/β1/γ23.072024-12-11doi.org/10.1073/pnas.2405732121
8JEFAAlicarboxylic acidHydroxycarboxylic AcidHCA3Homo sapiensPubChem 11367166-Gi1/β1/γ22.962024-12-18doi.org/10.1016/j.celrep.2024.114895
8XMLAProteinChemokineCCR8Homo sapiens--Gi1/β1/γ22.582025-01-01To be published
9IY8ALipidGPR55GPR55Homo sapiens--chim(NtGi1-G13)/β1/γ23.012025-01-01doi.org/10.1038/s41422-024-01046-8
9IZHALipidLysophospholipidLPA1Homo sapiensLPA-chim(NtGi2-G13)/β1/γ23.042025-01-01doi.org/10.1016/j.jsb.2024.108164
8JZPAPeptideComplement PeptideC5a1Homo sapiensC5a-Go/β1/γ23.542025-01-15To be published
8XWVAProteinChemokineCXCR2Homo sapiensCXCL1-Go/β1/γ23.072025-01-15doi.org/10.1016/j.molcel.2025.01.024
8XX3AProteinChemokineCXCR2Homo sapiensCXCL3-Go/β1/γ23.382025-01-15doi.org/10.1016/j.molcel.2025.01.024
8XX6AProteinChemokineCXCR2Homo sapiensCXCL8-Go/β1/γ22.992025-01-15doi.org/10.1016/j.molcel.2025.01.024
8XX7AProteinChemokineCXCR2Homo sapiensCXCL5-Go/β1/γ23.322025-01-15doi.org/10.1016/j.molcel.2025.01.024
8XXHAProteinChemokineCXCR2Homo sapiensCXCL2-Go/β1/γ22.82025-01-15doi.org/10.1016/j.molcel.2025.01.024
8XXRAProteinChemokineCXCR2Homo sapiens--Go/β1/γ23.172025-01-15doi.org/10.1016/j.molcel.2025.01.024
8XXXAProteinChemokineCXCR2Homo sapiensCXCL6-Go/β1/γ23.172025-01-15doi.org/10.1016/j.molcel.2025.01.024
8VVEAPeptideOpioidκHomo sapiensnorBNI-Gi1/β1/γ23.32025-01-15doi.org/10.1038/s41589-024-01812-0
8VVFAPeptideOpioidκHomo sapiensJDTic-Gi1/β1/γ232025-01-15doi.org/10.1038/s41589-024-01812-0
8VVGAPeptideOpioidκHomo sapiensGB18-Gi1/β1/γ23.32025-01-15doi.org/10.1038/s41589-024-01812-0
9D61APeptideOpioidκHomo sapiensJDTic-Gi1/β1/γ23.582025-01-15doi.org/10.1038/s41589-024-01812-0
9ITBALipidLysophospholipidLPA6Homo sapiensLPA-chim(NtGi1-Gs-CtGq)/β1/γ22.892025-01-15doi.org/10.1073/pnas.2415426122
9ITEALipidLysophospholipidLPA6Homo sapiensLPA-chim(NtGi2-G13)/β1/γ23.062025-01-15doi.org/10.1073/pnas.2415426122
8XQFAPeptideApelinApelinHomo sapiensApelin-13-Gi1/β1/γ23.132025-01-22doi.org/10.1038/s41467-024-55555-6
8Z7JAPeptideApelinApelinHomo sapiensJN241-9-Gi1/β1/γ23.122025-01-22doi.org/10.1038/s41467-024-55555-6
8XQEAPeptideApelinApelin; ApelinHomo sapiensApelin-13-Gi1/β1/γ23.482025-01-22doi.org/10.1038/s41467-024-55555-6
8ZJGAProteinChemerinCML1Homo sapiensChemerin-Gi1/β1/γ23.182025-01-22doi.org/10.1038/s42003-024-07228-9
8JSRAPeptideGhrelinGhrelinHomo sapiensAnamorelin-chim(NtGi1-Gs-CtGq)/β1/γ22.92025-01-22doi.org/10.1038/s41594-024-01481-6
8ZFZAOrphanOrphanGPR4Danio rerio--chim(NtGi1-Gs)/β1/γ23.32025-01-22doi.org/10.1038/s41467-025-55901-2
9BIPAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ22.82025-01-22doi.org/10.1016/j.cell.2024.11.036
9J31AOrphanOrphanGPR4Danio rerio--chim(NtGi1-Gs)/β1/γ23.052025-01-22doi.org/10.1038/s41467-025-55901-2
9BHLAOrphanOrphanGPR65Homo sapiens--Gs/β12.82025-01-22doi.org/10.1016/j.cell.2024.11.036
9BHMAOrphanOrphanGPR68Homo sapiens--Gs/β12.92025-01-22doi.org/10.1016/j.cell.2024.11.036
9BI6AOrphanOrphanGPR68Homo sapiens--chim(Gs-CtGq)/β1/γ22.92025-01-22doi.org/10.1016/j.cell.2024.11.036
9K26APeptideProlactin-Releasing PeptidePrRPHomo sapiensPrRP31-Gi1/β1/γ232025-01-29To be published
9K27APeptideProlactin-Releasing PeptidePrRPHomo sapiensPrRP31-chim(NtGi1-Gq)/β1/γ22.682025-01-29To be published
8Y62APeptideFormylpeptideFPR2-ALXHomo sapiensC16:0 Ceramide-Gi1/β1/γ23.22025-02-05doi.org/10.1126/science.ado4188
8Y63APeptideFormylpeptideFPR2-ALXHomo sapiensC20:0 Ceramide-Gi1/β1/γ23.22025-02-05doi.org/10.1126/science.ado4188
8YK0COrphanOrphanGPR156; GPR156Homo sapiens--Gi3/β1/γ22.42025-02-05doi.org/10.1038/s41467-024-54681-5
8X9SB2AdhesionAdhesionADGRD1Homo sapiens5α-DHT-chim(NtGi1-Gs)/β1/γ23.492025-02-12doi.org/10.1016/j.cell.2025.01.006
8X9TB2AdhesionAdhesionADGRD1Homo sapiensAP503-chim(NtGi1-Gs)/β1/γ22.752025-02-12doi.org/10.1016/j.cell.2025.01.006
8X9UB2AdhesionAdhesionADGRD1Homo sapiensMetenolone-chim(NtGi1-Gs)/β1/γ22.882025-02-12doi.org/10.1016/j.cell.2025.01.006
9IV1B2AdhesionAdhesionADGRD1Homo sapiens5α-DHT-chim(NtGi1-Gs)/β1/γ22.982025-02-12doi.org/10.1016/j.cell.2025.01.006
9IV2B2AdhesionAdhesionADGRD1Homo sapiens5α-DHT-chim(NtGi1-Gs)/β1/γ23.532025-02-12doi.org/10.1016/j.cell.2025.01.006
8Y51APeptideBombesinBB3Homo sapiens--chim(NtGi1-Gs-CtGq)/β1/γ23.32025-02-12To be published
8Y01ASensoryOpsinsOpsin1MWHomo sapiensAll-trans-Retinal-Gi1/β1/γ22.482025-02-12To be published
8ZD1AOrphanOrphanGPR4Xenopus tropicalis--chim(NtGi1-Gs)/β1/γ22.62025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF6AOrphanOrphanGPR4Xenopus tropicalis--chim(NtGi1-Gs)/β1/γ22.982025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZF9AOrphanOrphanGPR4Mus musculus--chim(NtGi1-Gs)/β1/γ22.562025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFAAOrphanOrphanGPR4Xenopus tropicalis--chim(NtGi1-Gs)/β1/γ22.962025-02-26doi.org/10.1016/j.cell.2024.12.001
8ZFCAOrphanOrphanGPR4Mus musculus--chim(NtGi1-Gs)/β1/γ22.682025-02-26doi.org/10.1016/j.cell.2024.12.001
9JVGAOrphanOrphanGPR4Mus musculus--chim(NtGi1-Gs)/β1/γ22.762025-02-26doi.org/10.1016/j.cell.2024.12.001
9GE2ALipidGPR55GPR55Homo sapiensML184-chim(NtGi1-G13)/β1/γ22.512025-03-05doi.org/10.1038/s41467-025-57204-y
9GE3ALipidGPR55GPR55Homo sapiensLysophosphatidylinositol-chim(NtGi1-G13)/β1/γ22.872025-03-05doi.org/10.1038/s41467-025-57204-y
8YFSAOrphanOrphanMRGPREEquus quaggaPubChem 641298-chim(NtGi1-Gs-CtGq)/β1/γ22.82025-03-05To be published
9L3WAProteinChemerinCML1Homo sapiensChemerin-Gi1/β1/γ23.52025-03-12doi.org/10.1093/procel/pwae073
9L3YAProteinChemerinCML2Homo sapiensChemerin-Gi1/β1/γ23.62025-03-12doi.org/10.1093/procel/pwae073
9JHJAPeptideFormylpeptideFPR2-ALXHomo sapiensC18:0 Ceramide-Gi1/β1/γ23.22025-03-19doi.org/10.1126/science.ado4188
8W8WAPeptideMelanocortinMC3Homo sapiensα-MSHCaGs/β1/γ22.92025-03-19To be published
8W8XAPeptideMelanocortinMC3Homo sapiensβ-MSHCaGs/β1/γ22.92025-03-19To be published
8W8YAPeptideMelanocortinMC3Homo sapiensγ-MSHCaGs/β1/γ22.92025-03-19To be published
9B5YB1PeptideParathyroid HormonePTH1Homo sapiensLA-PTH Analog-chim(NtGi1-Gq)/β1/γ23.492025-03-19doi.org/10.1073/pnas.2426178122
9EBNB1PeptideGlucagonGLP-1Homo sapiens--Gs/β1/γ23.442025-03-26doi.org/10.1073/pnas.2407574122
9EBOB1PeptideGlucagonGLP-1Homo sapiensGLP-1 (ACPC18)-Gs/β1/γ23.132025-03-26doi.org/10.1073/pnas.2407574122
9EBQB1PeptideGlucagonGLP-1Homo sapiens--Gs/β1/γ23.162025-03-26doi.org/10.1073/pnas.2407574122
9ARYAAmine5-Hydroxytryptamine5-HT2AHomo sapiensSerotonin-chim(NtGi1-Gs-CtGq)/β1/γ23.272025-04-02doi.org/10.1038/s41467-025-57956-7
9AS0AAmine5-Hydroxytryptamine5-HT2AHomo sapiens2-bromo-LSD-chim(NtGi1-Gs-CtGq)/β1/γ23.382025-04-02doi.org/10.1038/s41467-025-57956-7
9AS2AAmine5-Hydroxytryptamine5-HT2AHomo sapiensDMT-chim(NtGi1-Gs-CtGq)/β1/γ23.212025-04-02doi.org/10.1038/s41467-025-57956-7
9AS4AAmine5-Hydroxytryptamine5-HT2AHomo sapiensLSD-chim(NtGi1-Gs-CtGq)/β1/γ23.062025-04-02doi.org/10.1038/s41467-025-57956-7
9AS6AAmine5-Hydroxytryptamine5-HT2AHomo sapiensMescaline-chim(NtGi1-Gs-CtGq)/β1/γ23.072025-04-02doi.org/10.1038/s41467-025-57956-7
9ASAAAmine5-Hydroxytryptamine5-HT2AHomo sapiensRS130-180-chim(NtGi1-Gs-CtGq)/β1/γ23.122025-04-02doi.org/10.1038/s41467-025-57956-7
9AS8AAmine5-Hydroxytryptamine5-HT2AHomo sapiensPsilocin-chim(NtGi2L-Gs-CtGq)/β1/γ22.542025-04-0210.1038/s41467-025-57956-7
9IXXALipidLeukotrieneCysLT2Homo sapiensLTD4-chim(NtGi1-Gs-CtGq)/β1/γ23.152025-04-02doi.org/10.1073/pnas.2417148122
9CGJAPeptideOpioidδHomo sapiensC6-Quino-Gi1/β1/γ22.82025-04-02doi.org/10.1038/s41467-025-57734-5
9CGKAPeptideOpioidδHomo sapiensC5-Quino-Gi1/β1/γ22.622025-04-02doi.org/10.1038/s41467-025-57734-5
8Y6WALipidFree Fatty AcidFFA2Homo sapiensTUG-13754-CMTBGi1/β1/γ23.192025-04-02doi.org/10.1038/s41467-025-57983-4
9IZDAAlicarboxylic acidHydroxycarboxylic AcidHCA1Homo sapiensCHBA-Gi1/β1/γ23.162025-04-02doi.org/10.1371/journal.pbio.3003126
9J8ZAAlicarboxylic acidHydroxycarboxylic AcidHCA1Homo sapiens--Gi1/β1/γ23.362025-04-02doi.org/10.1371/journal.pbio.3003126
9IZAAAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensSCH900271-Gi1/β1/γ23.062025-04-02doi.org/10.1371/journal.pbio.3003126
9IZCAAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensMK1903-Gi1/β1/γ22.682025-04-02doi.org/10.1371/journal.pbio.3003126
9K6LT2SensoryTaste2TAS2R16Homo sapiensSalicin-Gi2/β1/γ22.772025-04-02doi.org/10.1016/j.celrep.2025.115604
9KPDT2SensoryTaste2TAS2R16Homo sapiensSalicin-chim(Gs-CtGt3)/β1/γ22.842025-04-02doi.org/10.1016/j.celrep.2025.115604
9KPET2SensoryTaste2TAS2R16Homo sapiensSalicin-Gi1/β1/γ23.352025-04-02doi.org/10.1016/j.celrep.2025.115604
9KPFT2SensoryTaste2TAS2R16Homo sapiensSalicin-Gi1/β1/γ23.152025-04-02doi.org/10.1016/j.celrep.2025.115604
9EE8ANucleotideAdenosineA2AHomo sapiensAdenosine-Gs/β1/γ22.632025-04-09doi.org/10.1038/s41467-025-56434-4
9EE9ANucleotideAdenosineA2AHomo sapiensAdenosine-Gs/β1/γ23.162025-04-09doi.org/10.1038/s41467-025-56434-4
9EEAANucleotideAdenosineA2AHomo sapiensAdenosine-Gs/β1/γ23.362025-04-09doi.org/10.1038/s41467-025-56434-4
9M1HALipidProstanoidEP1Homo sapiensPGE2-chim(NtGi1-Gs-CtGq)/β1/γ22.552025-04-09doi.org/10.1073/pnas.2423840122
9LYBAOrphanOrphanGPR3Homo sapiens--Gs/β1/γ23.162025-04-09doi.org/10.1016/j.celrep.2025.115478
9LYCAOrphanOrphanGPR3; GPR3Homo sapiens--Gs/β1/γ23.062025-04-09doi.org/10.1016/j.celrep.2025.115478
9JFYAPeptideNeuropeptide FFNPFF2Homo sapiensNeuropeptide-SF-Gi1/β1/γ23.212025-04-09doi.org/10.1038/s44319-025-00428-2
8YYWAAlicarboxylic acidOxoglutarateOxoglutarateHomo sapiensα-ketoglutarateα-ketoglutaratechim(Gi1-CtGq)/β1/γ23.192025-04-09To be published
8YYXAAlicarboxylic acidOxoglutarateOxoglutarateHomo sapiens-Leukotriene E4chim(Gi1-CtGq)/β1/γ22.842025-04-09To be published
9NOXCSensoryTaste1TAS1R2Homo sapiens--chim(Gs-CtGt3)/β1/γ232025-04-09doi.org/10.1016/j.cell.2025.04.021
9O38CSensoryTaste1TAS1R2; TAS1R3Homo sapiens--chim(Gs-CtGt3)/β1/γ232025-04-09doi.org/10.1016/j.cell.2025.04.021
9BLBB1PeptideCalcitoninCTHomo sapiensCagrilintide (non-acylated)-Gs/β1/γ23.22025-04-16doi.org/10.1038/s41467-025-58680-y
9BLCB1PeptideCalcitoninCTHomo sapiensCagrilintide (non-acylated)-Gs/β1/γ23.32025-04-16doi.org/10.1038/s41467-025-58680-y
9BUEB1PeptideCalcitoninCTHomo sapiensCagrilintide-Gs/β1/γ23.62025-04-16doi.org/10.1038/s41467-025-58680-y
9BLWB1PeptideCalcitoninCT (AMY1)Homo sapiensCagrilintide (non-acylated)-Gs/β1/γ2; RAMP13.22025-04-16doi.org/10.1038/s41467-025-58680-y
9BTWB1PeptideCalcitoninCT (AMY3)Homo sapiensCagrilintide-Gs/β1/γ2; RAMP332025-04-16To be published
8YWFB1PeptideGlucagonGLP-1Homo sapiensRetatrutide-chim(NtGi1-Gs)/β1/γ22.742025-04-16To be published
9JH3APeptideApelinApelin; ApelinHomo sapiensCMF-019-Gi1/β1/γ22.932025-04-23doi.org/10.1073/pnas.2423432122
9IPVAPeptideComplement PeptideC3aBHomo sapiensJR14a-Gi1/β1/γ22.532025-04-23doi.org/10.1038/s44318-025-00429-w
9BUBB1PeptideCalcitoninCTHomo sapiensCagrilintide-Gs/β1/γ22.32025-04-23doi.org/10.1038/s41467-025-58680-y
9BUCB1PeptideCalcitoninCTHomo sapiensCagrilintide-Gs/β1/γ23.42025-04-23doi.org/10.1038/s41467-025-58680-y
9BUDB1PeptideCalcitoninCTHomo sapiensCagrilintide-Gs/β1/γ22.52025-04-23doi.org/10.1038/s41467-025-58680-y
9BP3B1PeptideCalcitoninCT (AMY1)Homo sapiensCagrilintide-Gs/β1/γ2; RAMP12.22025-04-23doi.org/10.1038/s41467-025-58680-y
9BQ3B1PeptideCalcitoninCT (AMY2)Homo sapiensCagrilintide-Gs/β1/γ2; RAMP22.82025-04-23doi.org/10.1038/s41467-025-58680-y
9JH5ALipidLeukotrieneCysLT2Homo sapiensC16:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ22.762025-04-23doi.org/10.1038/s41586-025-08792-8
9JH6ALipidLeukotrieneCysLT2Homo sapiensC20:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ22.892025-04-23doi.org/10.1038/s41586-025-08792-8
8Z3MAOrphanOrphanGPR4Homo sapiens--chim(NtGi1-Gs-CtGq)/β1/γ22.92025-04-23To be published
8Z3QAOrphanOrphanGPR4Homo sapiens--chim(NtGi1-Gs)/β1/γ22.762025-04-23To be published
8Z65AOrphanOrphanGPR4Homo sapiens--chim(NtGi1-Gs)/β1/γ22.982025-04-23To be published
8ZCEAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ23.12025-04-23doi.org/10.1038/s41422-025-01092-w
8ZCFAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ22.92025-04-23doi.org/10.1038/s41422-025-01092-w
9JFVAOrphanOrphanGPR4Homo sapiens--chim(Gs-CtGq)/β1/γ22.672025-04-23doi.org/10.1038/s41422-025-01092-w
9JFWAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ23.132025-04-23doi.org/10.1038/s41422-025-01092-w
9JFXAOrphanOrphanGPR4Homo sapiens--chim(Gs-CtGq)/β1/γ22.872025-04-23doi.org/10.1038/s41422-025-01092-w
9JFZAOrphanOrphanGPR4Homo sapiens--chim(Gs-CtGq)/β1/γ22.92025-04-23doi.org/10.1038/s41422-025-01092-w
9JHPAOrphanOrphanGPR4Homo sapiens--chim(NtGi2-G13)/β1/γ23.352025-04-23doi.org/10.1038/s41422-025-01092-w
9LGMAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ22.842025-04-23doi.org/10.1038/s41422-025-01092-w
8Z5HAOrphanOrphanGPR68Homo sapiens--chim(NtGi1-Gs)/β1/γ23.32025-04-23To be published
8Z68AOrphanOrphanGPR68Homo sapiens--chim(NtGi1-Gs)/β1/γ22.642025-04-23To be published
9EGOALipidCannabinoidCB1Homo sapiensZ8526711350-Gi1/β1/γ23.22025-04-30doi.org/10.1038/s41467-025-57136-7
9IK8APeptideSomatostatinSST1Homo sapiensPasireotide-Gi1/β1/γ22.822025-04-30doi.org/10.1016/j.apsb.2025.03.043
9IK9APeptideSomatostatinSST1Homo sapiensLanreotide-Gi1/β1/γ23.372025-04-30doi.org/10.1016/j.apsb.2025.03.043
8ZBIAPeptideSomatostatinSST3Homo sapiensSomatostatin-14-Gi1/β1/γ22.792025-04-30To be published
8ZBJAPeptideSomatostatinSST5Homo sapiensSomatostatin-14-Gi1/β1/γ22.942025-04-30To be published
9D4ZAPeptideProteinase ActivatedPAR1Homo sapiens--chim(NtGi1L-Gs-CtGq)/β1/γ22.742025-05-07doi.org/10.1038/s41467-025-59138-x
9D0AAPeptideProteinase ActivatedPAR2Homo sapiens--chim(NtGi1L-Gs-CtGq)/β1/γ23.12025-05-07doi.org/10.1038/s41467-025-59138-x
9E7RAPeptideProteinase ActivatedPAR2Homo sapiensGB88-chim(NtGi1L-Gs-CtGq)/β1/γ23.182025-05-07doi.org/10.1038/s41467-025-59138-x
8ZWGAPeptideComplement PeptideC3aBHomo sapiensJR14a-Gi1/β1/γ22.872025-05-14doi.org/10.1038/s41421-024-00765-x
8S2TAAmineAdrenergicβ1Homo sapiensIsoprenaline-chim(NtGi1-Gs)/β1/γ23.32025-05-21To be published
9BUYAAmineAdrenergicβ2Homo sapiensLM189-Gi1/β1/γ22.92025-05-28doi.org/10.1126/sciadv.adq3971
8ZVZALipidProstaglandinDP1Homo sapiensBW245C-Gs/β1/γ22.352025-05-28doi.org/10.1073/pnas.2501902122
8ZW0ALipidProstaglandinDP1Homo sapiensPGD2-Gs/β1/γ22.722025-05-28doi.org/10.1073/pnas.2501902122
9JMCAPeptideMotilinMotilinHomo sapiensDS-3801b-chim(Gs-CtGq)/β1/γ22.572025-05-28doi.org/10.1016/j.celrep.2025.115329
9JMDAPeptideMotilinMotilinHomo sapiensAzithromycin-chim(Gs-CtGq)/β1/γ22.742025-05-28doi.org/10.1016/j.celrep.2025.115329
8ZMDAPeptideProteinase ActivatedPAR2Homo sapiens--chim(NtGi1L-Gs-CtGq)/β1/γ23.252025-05-28To be published
8ZMEAPeptideProteinase ActivatedPAR2Homo sapiens--chim(NtGi1-G13)/β1/γ23.22025-05-28To be published
9J0FANucleotideP2YP2Y14Homo sapiensNADH-Gi1/β1/γ22.762025-06-04doi.org/10.1038/s41421-025-00799-9
9J0IANucleotideP2YP2Y14Homo sapiensUDP-Glucuronic acid-Gi1/β1/γ22.762025-06-04doi.org/10.1038/s41421-025-00799-9
9J0BANucleotideP2YP2Y14Homo sapiensUDP-Glucose-Gi1/β1/γ22.882025-06-0410.1038/s41421-025-00799-9
8Z3YAOrphanOrphanGPR4Homo sapiens--chim(NtGi1-Gs)/β1/γ23.22025-06-04To be published
9BYOB1PeptideGlucagonGLP-1Homo sapiensExendin-3-Gs/β1/γ22.312025-06-11To be published
9C0KB1PeptideGlucagonGLP-1Homo sapiensExendin-4-Gs/β1/γ22.722025-06-11To be published
9LRBAAmineHistamineH1Homo sapiensHistamine-Gs/β1/γ22.772025-06-11doi.org/10.1038/s42003-025-08363-7
9LRDAAmineHistamineH1Homo sapiensHistamine-Gi1/β1/γ23.232025-06-11doi.org/10.1038/s42003-025-08363-7
9LREAAmineHistamineH4Homo sapiensHistamine-Gi1/β1/γ22.842025-06-11doi.org/10.1038/s42003-025-08363-7
8Y02ASensoryOpsinsOPN1SWHomo sapiensAll-trans-Retinal-Gi1/β1/γ22.612025-06-11To be published
9K0XANucleotideP2YP2Y2Homo sapiensATP-chim(NtGi1-Gs-CtGq)/β1/γ22.832025-06-11doi.org/10.1038/s41421-025-00797-x
9K20ANucleotideP2YP2Y2Homo sapiensATP-chim(NtGi1-Go)/β1/γ22.652025-06-11doi.org/10.1038/s41421-025-00797-x
9K25ANucleotideP2YP2Y2Homo sapiens--chim(NtGi1-Gs-CtGq)/β1/γ23.312025-06-11doi.org/10.1038/s41421-025-00797-x
9K0KANucleotideP2YP2Y4Homo sapiensUTP-chim(NtGi1-Gs-CtGq)/β1/γ23.142025-06-11doi.org/10.1038/s41421-025-00797-x
9U4WAPeptideGonadotrophin Releasing HormoneGnRH1Sus scrofaGonadoliberin-1-chim(NtGi1L-Gs-CtGq)/β1/γ23.182025-06-11doi.org/10.1073/pnas.2500112122
9U4YAPeptideGonadotrophin Releasing HormoneGnRH1Xenopus laevisGonadoliberin-1-chim(NtGi1L-Gs-CtGq)/β1/γ23.182025-06-11doi.org/10.1073/pnas.2500112122
9CLWALipidFree Fatty AcidFFA2Homo sapiensTUG-13754-CMTBchim(NtGi1L-Gs-CtGq)/β1/γ23.192025-06-25doi.org/10.1038/s41586-025-09186-6
9CM3ALipidFree Fatty AcidFFA2Homo sapiensTUG-1375PubChem 118615810chim(NtGi1L-Gs-CtGq)/β1/γ23.062025-06-25doi.org/10.1038/s41586-025-09186-6
9CM7ALipidFree Fatty AcidFFA2Homo sapiensTUG-1375AZ-1729Gi1/β1/γ23.292025-06-25doi.org/10.1038/s41586-025-09186-6
9NS9ALipidFree Fatty AcidFFA2Homo sapiensTUG-1375PubChem 118615810Gi1/β1/γ23.32025-06-25doi.org/10.1038/s41586-025-09186-6
9GL2AAmine5-Hydroxytryptamine5-HT1AHomo sapiensBefiradol-Gs/β1/γ23.22025-07-02doi.org/10.1126/sciadv.adv9267
9UY3APeptideGhrelinGhrelinHomo sapiensAnamorelin-chim(NtGi1-Gs-CtGq)/β1/γ22.522025-07-02doi.org/10.1038/s41401-025-01606-7
9V2NAPeptideGhrelinGhrelinHomo sapiensMacimorelin-chim(NtGi1-Gs-CtGq)/β1/γ22.632025-07-02doi.org/10.1038/s41401-025-01606-7
9USTAOrphanOrphanMRGPREEquus quaggaPubChem 641298-chim(NtGi1-Gs-CtGq)/β1/γ23.022025-07-02To be published
8Z9PAOrphanOrphanGPR4Homo sapiens--Gi1/β1/γ22.52025-07-09To be published
9JCOAOrphanOrphanGPR4Homo sapiens-LPCchim(NtGi1-Gs)/β1/γ22.362025-07-09doi.org/10.1038/s41421-025-00807-y
9JCPAOrphanOrphanGPR4Homo sapiens-LPCchim(NtGi1-Gs-CtGq)/β1/γ22.552025-07-09doi.org/10.1038/s41421-025-00807-y
9JCQAOrphanOrphanGPR4Homo sapiens-LPCchim(NtGi1-Gs)/β1/γ22.592025-07-09doi.org/10.1038/s41421-025-00807-y
9LWPAPeptideBombesinBB3Homo sapiens--chim(NtGi2L-Gs-CtGq)/β1/γ22.932025-07-16doi.org/10.1016/j.apsb.2025.06.025
9I52AAmineDopamineD1Homo sapiensA1IZU-Gs/β1/γ22.82025-07-16doi.org/10.1021/acs.jmedchem.5c00294
9I54AAmineDopamineD1Homo sapiensPubChem 176452091-Gs/β1/γ22.722025-07-16doi.org/10.1021/acs.jmedchem.5c00294
8Z9OAOrphanOrphanGPR4Homo sapiens--Gs/β1/γ22.42025-07-16To be published
9M0RAPeptideNeuropeptide FFNPFF1Homo sapiensNeuropeptide-VF-Gi1/β1/γ22.472025-07-23doi.org/10.1016/j.celrep.2025.116160
9M2FAPeptideNeuropeptide FFNPFF1Homo sapiensNeuropeptide-FF-Gi1/β1/γ22.932025-07-23doi.org/10.1016/j.celrep.2025.116160
9M1OAPeptideNeuropeptide FFNPFF2Homo sapiensNeuropeptide-FF-Gi1/β1/γ22.492025-07-23doi.org/10.1016/j.celrep.2025.116160
9M54APeptideNeuropeptide FFNPFF2Homo sapiensNeuropeptide-VF-Gi1/β1/γ23.242025-07-23doi.org/10.1016/j.celrep.2025.116160
9V0UB2AdhesionAdhesionADGRD1Homo sapiens--chim(NtGi1-G13)/β1/γ23.512025-07-30doi.org/10.1016/j.bbrc.2025.152165
9IV6AOrphanOrphanGPR4Homo sapiens--chim(NtGi1-Gs)/β1/γ22.712025-07-30To be published
9IXJAAmineHistamineH2Homo sapiensHistamine-Gs/β1/γ22.922025-07-30To be published
9K3PAPeptideMelanocortinMC1Homo sapiens--chim(NtGi1-Gs)/β1/γ22.982025-08-06doi.org/10.1016/j.str.2025.03.004
9K3LAPeptideMelanocortinMC2Homo sapiens--chim(NtGi1-Gs)/β1/γ23.012025-08-06doi.org/10.1016/j.str.2025.03.004
9K3FAPeptideMelanocortinMC3Homo sapiens--chim(NtGi1-Gs)/β1/γ22.752025-08-06doi.org/10.1016/j.str.2025.03.004
9K3KAPeptideMelanocortinMC4Homo sapiens--chim(NtGi1-Gs)/β1/γ23.122025-08-06doi.org/10.1016/j.str.2025.03.004
9K3HAPeptideMelanocortinMC5Homo sapiens--chim(NtGi1-Gs)/β1/γ22.862025-08-06doi.org/10.1016/j.str.2025.03.004
8Y72APeptideOpioidμHomo sapiensPeptideBMS-986122Gi1/β1/γ22.652025-08-06To be published
8Y73APeptideOpioidμHomo sapiensPeptideMPAM-15Gi1/β1/γ22.842025-08-06To be published
9DYDAAmine5-Hydroxytryptamine5-HT1AHomo sapiensAsenapinePtdIns4PGo/β1/γ22.962025-08-13doi.org/10.1126/sciadv.adu9851
9DYEAAmine5-Hydroxytryptamine5-HT1AHomo sapiensBuspironePtdIns4PGo/β1/γ22.92025-08-13doi.org/10.1126/sciadv.adu9851
9DYFAAmine5-Hydroxytryptamine5-HT1AHomo sapiensAsenapinePtdIns4PGi1/β1/γ22.742025-08-13doi.org/10.1126/sciadv.adu9851
8YKDB2AdhesionAdhesionADGRG2Mus musculusDehydroepiandrosterone-chim(NtGi1-Gs)/β1/γ22.92025-08-13doi.org/10.1038/s41589-025-01896-2
9JFTAOrphanOrphanGPR65Homo sapiens--Gs/β1/γ23.272025-08-13doi.org/10.1038/s41422-025-01092-w
9KFIAPeptideRelaxinRXFP3Homo sapiensRelaxin-3-Gi2/β1/γ22.912025-08-13doi.org/10.1038/s42003-025-08220-7
9KFJAPeptideRelaxinRXFP3Homo sapiensPubChem 138319674-Gi2/β1/γ23.12025-08-13doi.org/10.1038/s42003-025-08220-7
9KFKAPeptideRelaxinRXFP4Homo sapiensRelaxin-3-Gi2/β1/γ22.952025-08-13doi.org/10.1038/s42003-025-08220-7
9EBHANucleotideAdenosineA3AHomo sapiensAdenosine-Gi1/β1/γ23.62025-08-20doi.org/10.1038/s41467-025-62872-x
9EBIANucleotideAdenosineA3AHomo sapiensPiclidenoson-chim(NtGi1L-Gs-CtGi1)/β1/γ23.62025-08-20doi.org/10.1038/s41467-025-62872-x
9PLOAAmineAdrenergicα2aHomo sapiensPubChem 168259594-Go/β1/γ22.742025-08-20To be published
9K07APeptideBombesinBB3Homo sapiensDSO-5a-chim(NtGi2L-Gs-CtGq)/β1/γ22.872025-08-27doi.org/10.1016/j.apsb.2025.06.025
9AU0ALipidProstaglandinDP1Homo sapiensBW245C-Gs/β1/γ22.452025-08-27To be published
9GG5ALipidProstanoidTXA2Homo sapiensU46619-chim(NtGi2L-Gs-CtGq)/β1/γ23.262025-08-27To be published
9GGGALipidProstanoidTXA2Homo sapiensI-BOP-chim(NtGi2L-Gs-CtGq)/β1/γ23.252025-08-27To be published
8YFOB1PeptideParathyroid HormonePTH1Homo sapiensAc-LA-PTH Analog-chim(NtGi1-Gs)/β1/γ22.712025-09-03To be published
8YG4B1PeptideParathyroid HormonePTH1Homo sapiensLA-PTH Analog-chim(NtGi1-Gs)/β1/γ22.592025-09-03To be published
8ZBWAPeptideFormylpeptideFPR2-ALXHomo sapiensQuin-C1-Gi2/β1/γ22.582025-09-10doi.org/10.1038/s41401-025-01525-7
9E2AB1PeptideGlucagonGLP-1Homo sapiensGLP-1-Gs/β1/γ23.32025-10-29To be published
8Z8AAAlicarboxylic acidHydroxycarboxylic AcidHCA1Homo sapiensLactate-Gi1/β1/γ22.822025-10-29To be published
8Z8BAAlicarboxylic acidHydroxycarboxylic AcidHCA1Homo sapiens--Gi1/β1/γ22.652025-10-29To be published
8Z87AAlicarboxylic acidHydroxycarboxylic AcidHCA1Homo sapiensCHBA-Gi1/β1/γ22.732025-11-05To be published
9VJ5AAmine5-Hydroxytryptamine5-HT1AHomo sapiensGepirone-Go/β1/γ22.692025-11-12To be published
9VJ6AAmine5-Hydroxytryptamine5-HT1AHomo sapiensF-15599-Gi3/β1/γ22.622025-11-12To be published
9VJEAAmine5-Hydroxytryptamine5-HT1AHomo sapiensBuspirone-Go/β1/γ22.472025-11-12To be published
9VJFAAmine5-Hydroxytryptamine5-HT1AHomo sapiensBuspirone-Gi3/β1/γ22.72025-11-12To be published
9VJGAAmine5-Hydroxytryptamine5-HT1AHomo sapiens8-OH-DPAT-chim(NtGi2-Gz)/β1/γ22.672025-11-12To be published
9VMYAAmine5-Hydroxytryptamine5-HT1AHomo sapiensTMU4142-Go/β1/γ22.862025-11-12To be published
9VNFAAmine5-Hydroxytryptamine5-HT1AHomo sapiensPindolol-Go/β1/γ22.742025-11-12To be published
9E51B2AdhesionAdhesionADGRL2Homo sapiens--chim(NtGi2-G13)/β1/γ22.92025-11-12To be published
9KFTAPeptideFormylpeptideFPR1-ALXHomo sapiensfMLFC-Gi1/β1/γ23.062025-11-12To be published
9PXVAPeptideOpioidμHomo sapiensNaloxone-Gi1/β1/γ23.022025-11-1210.1038/s41586-025-09677-6
9PXWAPeptideOpioidμHomo sapiensNaloxoneGDPβSGi1/β1/γ23.82025-11-1210.1038/s41586-025-09677-6
9PXXAPeptideOpioidμHomo sapiensNaloxoneGDPβSGi1/β1/γ23.12025-11-1210.1038/s41586-025-09677-6
9PXYAPeptideOpioidμHomo sapiensNaloxoneGDPβSGi1/β1/γ232025-11-1210.1038/s41586-025-09677-6
9PY2APeptideOpioidμHomo sapiensLoperamideGDPβSGi1/β1/γ23.162025-11-1210.1038/s41586-025-09677-6
9PY3APeptideOpioidμHomo sapiensLoperamideGDPβSGi1/β1/γ23.22025-11-12To be published
9PY4APeptideOpioidμHomo sapiensLoperamideGDPβSGi1/β1/γ22.782025-11-1210.1038/s41586-025-09677-6
9WXMAOrphanOrphanGPR15Homo sapiensGPR15L(CT)-Gi3/β1/γ23.32025-11-1910.1016/j.isci.2025.113935
9V6OAPeptideOpioidκHomo sapiensNalfurafine-Gi1/β1/γ22.762025-11-1910.1038/s41467-025-64882-1
9W49APeptideOpioidκHomo sapiensU-50488H-Gi1/β1/γ22.92025-11-1910.1038/s41467-025-64882-1
9YDUANucleotideP2YP2Y14Homo sapiensUDP-Glucose-Gi1/β1/γ23.192025-11-1910.1038/s42003-025-09174-6
9YDVANucleotideP2YP2Y14Homo sapiensMRS2905-Gi1/β1/γ23.052025-11-1910.1038/s42003-025-09174-6
9P92B1PeptideVIP and PACAPPAC1Homo sapiensVIP-Gs/β1/γ23.82025-11-1910.1073/pnas.2521157122
9P93B1PeptideVIP and PACAPPAC1Homo sapiensVIP-Gs/β1/γ23.22025-11-1910.1073/pnas.2521157122
9P94B1PeptideVIP and PACAPPAC1Homo sapiensPACAP27-Gs/β1/γ232025-11-1910.1073/pnas.2521157122
9W6WAAmine5-Hydroxytryptamine5-HT5AHomo sapiens5-CT-Gi1/β1/γ23.132025-11-2610.1186/s43556-025-00359-3
9KUTAPeptideComplement PeptideC3aBHomo sapiensJR14a-Go/β1/γ23.292025-11-2610.1101/2025.05.26.656101
9KV6APeptideComplement PeptideC3aBMus musculusTLQP21-Go/β1/γ22.882025-11-2610.1101/2025.05.26.656101
9KV8APeptideComplement PeptideC3aBMus musculusTLQP21-Go/β1/γ23.172025-11-2610.1101/2025.05.26.656101
9KUGAPeptideComplement PeptideC5a1Homo sapiensEP67-Go/β1/γ23.072025-11-2610.1101/2025.05.26.656101
9KO2AProteinChemokineCCR7Homo sapiensCCL19-Gi1/β12.982025-11-26To be published
9KO4AProteinChemokineCCR7Homo sapiensCCL21-Gi1/β1/γ23.32025-11-26To be published
9KVGAAmine5-Hydroxytryptamine5-HT1AHomo sapiens5-MeO-DMTPtdIns4PGi1/β1/γ22.632025-12-03To be published
9KVHAAmine5-Hydroxytryptamine5-HT1AHomo sapiensCinobufoteninePtdIns4PGi1/β1/γ22.592025-12-03To be published
9KVIAAmine5-Hydroxytryptamine5-HT1AHomo sapiensBufoteninPtdIns4PGi1/β1/γ22.542025-12-03To be published
9VI9APeptideNeuropeptide FFNPFF1Homo sapiensRFRP-3-Gi1/β1/γ23.022025-12-0310.1093/procel/pwaf090
9VIFAPeptideNeuropeptide FFNPFF1Homo sapiensNeuropeptide-VF-Gi1/β1/γ23.192025-12-0310.1093/procel/pwaf090
9JFKAPeptideUrotensinUTHomo sapiens(Pen5)-Urotensin II-chim(NtGi2L-Gs-CtGq)/β1/γ23.232025-12-0310.1016/j.jbc.2025.110794
9YDPAPeptideOpioidδHomo sapiensDADLE-chim(NtGi1L-Gs-CtGi1)/β1/γ21.952025-12-1010.1101/2025.10.16.682975
9YDQAPeptideOpioidδHomo sapiensDADLEMIPS3614chim(NtGi1L-Gs-CtGi1)/β1/γ21.942025-12-1010.1101/2025.10.16.682975
9YDRAPeptideOpioidδHomo sapiensDADLEMIPS3983chim(NtGi1L-Gs-CtGi1)/β1/γ22.142025-12-1010.1101/2025.10.16.682975
9KT9AAlicarboxylic acidHydroxycarboxylic AcidHCA1Homo sapiens3,5-DHBA-Gi1/β1/γ22.72025-12-1010.1021/acs.jmedchem.4c02567
9KT7AAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensMK6892-Gi1/β1/γ22.82025-12-1010.1021/acs.jmedchem.4c02567
9KT8AAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensAcifran-Gi1/β1/γ22.732025-12-1010.1021/acs.jmedchem.4c02567
9KT6AAlicarboxylic acidHydroxycarboxylic AcidHCA3Homo sapiensAcifran-Gi1/β1/γ23.012025-12-1010.1021/acs.jmedchem.4c02567
9JICAAlicarboxylic acidHydroxycarboxylic AcidHCA3Homo sapiens--Gi1/β1/γ23.42025-12-1710.1016/j.celrep.2024.114895
9JIDAAlicarboxylic acidHydroxycarboxylic AcidHCA3Homo sapiensNiacin-Gi1/β1/γ22.782025-12-1710.1016/j.celrep.2024.114895
9M55AAmineAdrenergicOct-Beta2Ixodes scapularisDPMF-chim(NtGi1-Gs)/β1/γ23.392025-12-1710.1093/pnasnexus/pgaf376
9M57AAmineAdrenergicOct-Beta2Ixodes scapularisOctopamine-chim(NtGi1-Gs)/β1/γ23.652025-12-1710.1093/pnasnexus/pgaf376
9YDAASensoryOpsinsOpsin1MWHomo sapiensAll-trans-Retinal-chim(NtGi1L-Gs-CtGt)/β1/γ22.92025-12-2410.1073/pnas.2516318122
9L84AAmineAdrenergicβ1Homo sapiensEpinephrineAtazanavirGs/β1/γ23.222025-12-31To be published
9L8LAAmineAdrenergicβ2Homo sapiensBI167107AtazanavirGs/β1/γ2 ; Arrestin23.222025-12-31To be published
9L79ALipidGPR119GPR119Homo sapiensAR231453-chim(NtGi1-Gs)/β1/γ22.982025-12-31To be published
9L80ALipidGPR119GPR119Homo sapiens-Atazanavirchim(NtGi1-Gs)/β1/γ23.332025-12-31To be published
9L60APeptideOpioidκHomo sapiensDynorphinMPAM-15Gi1/β1/γ22.92025-12-31To be published
8Y71APeptideOpioidδHomo sapiensA1D6FBMS986187Gi1/β1/γ22.972026-01-07To be published
9ODJAPeptideOpioidμMus musculusMitragynine PseudoindoxylGTP; MgGi1/β1/γ232026-01-0710.1038/s41586-025-10056-4
9ODKAPeptideOpioidμMus musculus-GTP; MgGi1/β1/γ23.92026-01-0710.1038/s41586-025-10056-4
9ODLAPeptideOpioidμMus musculusMitragynine PseudoindoxylGTP; MgGi1/β1/γ23.62026-01-0710.1038/s41586-025-10056-4
9LL9AAmine5-Hydroxytryptamine5-HT2AHomo sapiensDOI-chim(NtGi1L-Gs-CtGq)/β1/γ22.762026-01-14To be published
9LLAAAmine5-Hydroxytryptamine5-HT2AHomo sapiensAriadne-chim(NtGi1L-Gs-CtGq)/β1/γ23.272026-01-14To be published
9LLBAAmine5-Hydroxytryptamine5-HT2AHomo sapiensDOI-NBOMe-chim(NtGi1L-Gs-CtGq)/β1/γ22.982026-01-14To be published
9LL7AAmine5-Hydroxytryptamine5-HT2AHomo sapiensDOI-Gi1/β1/γ22.842026-01-14To be published
9LL8AAmine5-Hydroxytryptamine5-HT2AHomo sapiensPsilocin-Gi1/β1/γ22.622026-01-14To be published
9QXLB2AdhesionAdhesionADGRL4Homo sapiens--chim(Gs-CtGq)/β1/γ23.142026-01-14To be published
9HYIAAmine5-Hydroxytryptamine5-HT1AHomo sapiensDP81-Gi1/β1/γ22.32026-01-21To be published
9M42AOrphanOrphanGPR139Homo sapiensA1L8O-chim(Gs-CtGq)/β1/γ23.22026-01-2110.1038/s41467-025-66845-y
9LKBO2OdorantOdorant family 5OR5V1Mus musculusPL45-chim(NtGi1-Gs)/β13.72026-01-21To be published