psnGPCRdb

Dimers → Single PSN

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Show: Click this button to access the corresponding database entry page.

PDB: PDB code of the receptor used to compute the network and a direct link to the corresponding entry in the Protein Data Bank.

Class: Receptor Class.

SubFamily: Receptor Sub Family.

Type: Receptor Type.

Subtype: Receptor SubType.

Species: Organism.

Orthosteric Ligand: Name of the orthosteric ligand, if present.

Other Ligand(s): Name of other allosteric ligands, if present.

Protein Partners: G Protein, Arrestin or Kinase coupled to a given receptor.

Resolution: Structure resolution.

Date: Deposition date.

DOI: DOI and link of the corresponding paper.


ShowPDBClassSubFamilyTypeSubTypeSpeciesOrthosteric LigandOther Ligand(s)Protein PartnersResolutionDateDOI
4OR2CAmino acidMetabotropic glutamatemGlu1; mGlu1Homo sapiens-FITM-2.82014-03-1910.1126/science.1249489
6N51CAmino acidMetabotropic glutamatemGlu5; mGlu5Homo sapiensQuisqualate--42019-01-2310.1038/s41586-019-0881-4
6N52CAmino acidMetabotropic glutamatemGlu5; mGlu5Homo sapiens---42019-01-2310.1038/s41586-019-0881-4
6UO8CAmino acidGABABGABAB1, GABAB2Homo sapiensSKF97541GS39783-3.632020-06-1010.1038/s41586-020-2408-4
6UO9CAmino acidGABABGABAB1, GABAB2Homo sapiensSKF97541--4.82020-06-1010.1038/s41586-020-2408-4
6UOACAmino acidGABABGABAB1, GABAB2Homo sapiens---6.32020-06-1010.1038/s41586-020-2408-4
6VJMCAmino acidGABABGABAB1, GABAB2Homo sapiens---3.972020-06-1010.1038/s41586-020-2408-4
6W2XCAmino acidGABABGABAB1, GABAB2Homo sapiensPubChem 5311042PubChem 23727970-3.62020-07-0110.1038/s41586-020-2469-4
6W2YCAmino acidGABABGABAB1; GABAB1Homo sapiensPubChem 5311042PubChem 23727970-3.22020-07-0110.1038/s41586-020-2469-4
6WIVCAmino acidGABABGABAB1, GABAB2Homo sapiens-PubChem 52923113; PubChem 52924645-3.32020-07-0110.1038/s41586-020-2452-0
7AD3D1Ste2-likeSTE2STE2Saccharomyces cerevisiaeAlpha-factor mating pheromone-Gi1/STE4/&γ;23.32020-12-0910.1038/s41586-020-2994-1
7C7QCAmino acidGABABGABAB1, GABAB2Homo sapiensBaclofenPubChem 7023848-32020-07-0110.1038/s41422-020-0350-5
7C7SCAmino acidGABABGABAB1, GABAB2Homo sapiensCGP54626--2.92020-07-0110.1038/s41422-020-0350-5
7CA3CAmino acidGABABGABAB1, GABAB2Homo sapiens-rac-BHFF-4.52020-11-1110.1016/j.jmb.2020.09.023
7CA5CAmino acidGABABGABAB1, GABAB2Homo sapiens---7.62020-11-1110.1016/j.jmb.2020.09.023
7CUMCAmino acidGABABGABAB1, GABAB2Homo sapiensCGP54626Phospholipid-3.522020-11-1110.1016/j.jmb.2020.09.023
7DD5CIonCalcium-sensingCaSGallus gallusCaCa; Ca; Tryptophan; NPS-2143-3.22021-06-1610.1126/sciadv.abg1483
7DD6CIonCalcium-sensingCaSGallus gallusCaCa; Ca; Tryptophan-3.22021-06-1610.1126/sciadv.abg1483
7DD7CIonCalcium-sensingCaSGallus gallusCaCa; Ca; Tryptophan; Evocalcet-3.22021-06-1610.1126/sciadv.abg1483
7DGDCAmino acidMetabotropic glutamatemGlu1; mGlu1Homo sapiens---3.962021-09-2210.1007/s13238-020-00808-5
7DGECAmino acidMetabotropic glutamatemGlu1; mGlu1Homo sapiensQuisqualate--3.652021-09-2210.1007/s13238-020-00808-5
7DTTCIonCalcium-sensingCaSHomo sapiensCaCa-3.82021-03-1010.1038/s41422-021-00474-0
7DTUCIonCalcium-sensingCaSHomo sapiens-Tryptophan-4.42021-03-1010.1038/s41422-021-00474-0
7DTVCIonCalcium-sensingCaSHomo sapiensCaCa; Tryptophan-3.52021-03-1010.1038/s41422-021-00474-0
7DTWCIonCalcium-sensingCaSHomo sapiens---4.52021-03-1010.1038/s41422-021-00474-0
7E6TCIonCalcium-sensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; PO4-32021-09-2210.7554/eLife.68578
7E6UCIonCalcium-sensingCaSHomo sapiens---62021-09-2210.7554/eLife.68578
7E9GCAmino acidMetabotropic glutamatemGlu2; mGlu2Homo sapiensEglumetadJNJ-40411813Gi1/&β;1/&γ;23.52021-06-2310.1038/s41586-021-03495-2
7E9HCAmino acidMetabotropic glutamatemGlu4; mGlu4Homo sapiensPhosphoserine-Gi3/&β;1/&γ;242021-06-2310.1038/s41586-021-03495-2
7EB2CAmino acidGABABGABAB1, GABAB2Homo sapiensBaclofenrac-BHFFGi1/&β;1/&γ;23.52021-05-0510.1038/s41586-021-03507-1
7EPACAmino acidMetabotropic glutamatemGlu2; mGlu2Homo sapiens---3.62021-06-2310.1038/s41586-021-03641-w
7EPBCAmino acidMetabotropic glutamatemGlu2; mGlu2Homo sapiensEglumetad--3.12021-06-2310.1038/s41586-021-03641-w
7EPCCAmino acidMetabotropic glutamatemGlu7; mGlu7Homo sapiens---42021-06-2310.1038/s41586-021-03641-w
7EPDCAmino acidMetabotropic glutamatemGlu2, mGlu7Homo sapiens---3.92021-06-2310.1038/s41586-021-03641-w
7EWLCOrphanC orphansGPR158Homo sapiens---3.522021-12-0110.1038/s41467-021-27147-1
7EWPCOrphanC orphansGPR158Homo sapiens--B5; RGS74.32021-12-0110.1038/s41467-021-27147-1
7EWRCOrphanC orphansGPR158Homo sapiens--B5; RGS74.72021-12-0110.1038/s41467-021-27147-1
7FD8CAmino acidMetabotropic glutamatemGlu5; mGlu5Homo sapiensQuisqualate--3.82021-09-0810.1016/j.celrep.2021.109648
7FD9CAmino acidMetabotropic glutamatemGlu5; mGlu5Homo sapiensLY341495--42021-09-0810.1016/j.celrep.2021.109648
7M3ECIonCalcium-sensingCaSHomo sapiens-Ca; Ca; Tryptophan; NPS-2143; PO4-3.22021-06-3010.1038/s41586-021-03691-0
7M3FCIonCalcium-sensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4-2.82021-06-3010.1038/s41586-021-03691-0
7M3GCIonCalcium-sensingCaSHomo sapiens-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4-2.52021-06-3010.1038/s41586-021-03691-0
7M3JCIonCalcium-sensingCaSHomo sapiens-NPS-2143; PO4-4.12021-06-3010.1038/s41586-021-03691-0
7MTQCAmino acidMetabotropic glutamatemGlu2; mGlu2Homo sapiensLY341495--3.652021-07-0710.1038/s41586-021-03680-3
7MTRCAmino acidMetabotropic glutamatemGlu2; mGlu2Homo sapiensGlutamateADX55164-3.32021-07-0710.1038/s41586-021-03680-3
7MTSCAmino acidMetabotropic glutamatemGlu2; mGlu2Homo sapiensGlutamateADX55164Gi1/&β;1/&γ;23.22021-07-0710.1038/s41586-021-03680-3
7QA8D1Ste2-likeSTE2STE2Saccharomyces cerevisiaePeptide--2.72022-03-1610.1038/s41586-022-04498-3
7QB9D1Ste2-likeSTE2STE2Saccharomyces cerevisiae---3.12022-03-1610.1038/s41586-022-04498-3
7QBCD1Ste2-likeSTE2STE2Saccharomyces cerevisiaeAlpha-factor mating pheromone--3.532022-03-1610.1038/s41586-022-04498-3
7QBID1Ste2-likeSTE2STE2Saccharomyces cerevisiaeAlpha-factor mating pheromone--3.462022-03-1610.1038/s41586-022-04498-3
7SHECOrphanC orphansGPR158Homo sapiens-PI; PE-3.42021-12-0110.1126/science.abl4732
7SHFCOrphanC orphansGPR158Homo sapiens-PI; PEB5; RGS73.42021-12-0110.1126/science.abl4732
7SILCIonCalcium-sensingCaSHomo sapiensCaCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-2.72022-01-1910.1073/pnas.2115849118
7SIMCIonCalcium-sensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; PO4-2.72022-01-1910.1073/pnas.2115849118
7SINCIonCalcium-sensingCaSHomo sapiens-NPS-2143-5.92022-01-1910.1073/pnas.2115849118
7W0LAPeptideApelinApelinHomo sapiensPubChem 122701908-Gi1/&β;1/&γ;23.572022-07-2710.1038/s41594-022-00797-5
7W0NAPeptideApelinApelinHomo sapiensElabela-Gi1/&β;1/&γ;24.212022-07-2710.1038/s41594-022-00797-5
7WI6CAmino acidMetabotropic glutamatemGlu3; mGlu3Homo sapiensLY341495--3.712022-03-1610.1038/s41422-022-00623-z
7WI8CAmino acidMetabotropic glutamatemGlu3; mGlu3Homo sapiensLY341495--4.172022-03-1610.1038/s41422-022-00623-z
7WIHCAmino acidMetabotropic glutamatemGlu3; mGlu3Homo sapiensLY2794193--3.682022-03-1610.1038/s41422-022-00623-z
8JCUCAmino acidMetabotropic glutamatemGlu2; mGlu3Homo sapiensLY341495--2.82023-06-2110.1038/s41422-023-00830-2
8JCVCAmino acidMetabotropic glutamatemGlu2; mGlu3Homo sapiensLY341495--3.42023-06-2110.1038/s41422-023-00830-2
8JCWCAmino acidMetabotropic glutamatemGlu2; mGlu3Homo sapiensLY341495--32023-06-2110.1038/s41422-023-00830-2
8JCXCAmino acidMetabotropic glutamatemGlu2; mGlu3Homo sapiensLY341495--32023-06-2110.1038/s41422-023-00830-2
8JCYCAmino acidMetabotropic glutamatemGlu2; mGlu3Homo sapiensLY341495--2.92023-06-2110.1038/s41422-023-00830-2
8JCZCAmino acidMetabotropic glutamatemGlu2; mGlu3Homo sapiensLY341495--32023-06-2110.1038/s41422-023-00830-2
8JD0CAmino acidMetabotropic glutamatemGlu2; mGlu3Homo sapiensGlutamateJ9R-3.32023-06-2110.1038/s41422-023-00830-2
8JD1CAmino acidMetabotropic glutamatemGlu2; mGlu3Homo sapiensGlutamate--3.72023-06-2110.1038/s41422-023-00830-2
8JD2CAmino acidMetabotropic glutamatemGlu2; mGlu3Homo sapiensGlutamate--2.82023-06-2110.1038/s41422-023-00830-2
8JD3CAmino acidMetabotropic glutamatemGlu2; mGlu3Homo sapiensGlutamateHZR; PEFGi1/&β;1/&γ;23.32023-06-2110.1038/s41422-023-00830-2
8JD4CAmino acidMetabotropic glutamatemGlu2; mGlu4Homo sapiensGlutamate--2.92023-06-2110.1038/s41422-023-00830-2
8JD5CAmino acidMetabotropic glutamatemGlu2; mGlu4Homo sapiensGlutamateBQI; HZE; PEFGi1/&β;1/&γ;23.62023-06-2110.1038/s41422-023-00830-2
8JD6CAmino acidMetabotropic glutamatemGlu4; mGlu4Homo sapiensPhosphoserineN-(3-chlorophenyl)pyridine-2-carboxamideGi3/&β;1/&γ;23.42023-06-2110.1038/s41422-023-00830-2
8T6JCAmino acidMetabotropic glutamatemGlu5; mGlu5Homo sapiens-CDPPB-3.52023-10-1110.1101/2023.08.29.555158
8T7HCAmino acidMetabotropic glutamatemGlu5; mGlu5Homo sapiensQuisqualate--3.32023-10-1110.1101/2023.08.29.555158
8T8MCAmino acidMetabotropic glutamatemGlu5; mGlu5Homo sapiensQuisqualate--32023-10-1110.1101/2023.08.29.555158
8TAOCAmino acidMetabotropic glutamatemGlu5; mGlu5Homo sapiensQuisqualateCDPPB-2.92023-10-1110.1101/2023.08.29.555158
8WPGCIonCalcium-sensingCaSHomo sapiens-Tryptophan; Cinacalcet; PO4; Ca-2.72023-11-2210.1038/s41422-023-00892-2
8WPUCIonCalcium-sensingCaSHomo sapiens-Tryptophan; Cinacalcet; PO4; Cachim(Gi1-Gs)/&β;1/&γ;23.12023-11-2210.1038/s41422-023-00892-2
3CAP (Dimer)ASensoryOpsinsRhodopsinBos taurus---2.92008-06-2410.1038/nature07063
3ODU (Dimer)AProteinChemokineCXCR4Homo sapiens-IT1t-2.52010-10-2710.1126/science.1194396
3OE8 (Dimer)AProteinChemokineCXCR4Homo sapiens-IT1t-3.12010-10-2710.1126/science.1194396
3OE9 (Dimer)AProteinChemokineCXCR4Homo sapiens-IT1t-3.12010-10-2710.1126/science.1194396
4DJH (Dimer)APeptideOpioidκHomo sapiensJDTic--2.92012-03-2110.1038/nature10939
4GPO (Dimer)AAmineAdrenergicβ1Meleagris gallopavo---3.52013-02-2710.1038/nsmb.2504
4JKV (Dimer)FProteinFrizzledSMOHomo sapiensTaladegib (LY2940680)--2.452013-04-2410.1038/nature12167
5O9H (Dimer)APeptideComplement peptideC5a1Homo sapiens-NDT9513727-2.72018-01-1010.1038/nature25025
6AK3 (Dimer)ALipidProstanoidEP3Homo sapiensDinoprostone IPGE2--2.92018-12-0510.1038/s41589-018-0171-8
6KUW (Dimer)AAmineAdrenergicα2cHomo sapiensPubChem 57213234--2.82019-12-0410.1038/nature06325
6OFJ (Dimer)ASensoryOpsinsRhodopsinBos taurus---4.52019-08-2110.1074/jbc.RA119.010089
6WGT (Dimer)AAmine5-Hydroxytryptamine5-HT2AHomo sapiensLSD--3.42020-09-2310.1016/j.cell.2020.08.024
6WH4 (Dimer)AAmine5-Hydroxytryptamine5-HT2AHomo sapiensMethiothepin--3.42020-09-2310.1016/j.cell.2020.08.024
6YVR (Dimer)APeptideNeurotensinNTS1Rattus norvegicusNTS8-13--2.462021-02-1010.1126/sciadv.abe5504
8FCZ (Dimer)ASensoryOpsinsRhodopsinBos taurus11-cis-Retinal--3.72023-08-30To be published
8FD0 (Dimer)ASensoryOpsinsRhodopsinBos taurus--Nanobody extra3.712023-08-3010.1038/s41467-023-40911-9
8FD1 (Dimer)ASensoryOpsinsRhodopsinBos taurus--Nanobody extra4.252023-08-30To be published