psnGPCRdb

Dimers → Single PSN

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Show: Click this button to access the corresponding database entry page.

PDB: PDB code of the receptor used to compute the network and a direct link to the corresponding entry in the Protein Data Bank.

Class: Receptor Class.

SubFamily: Receptor Sub Family.

Type: Receptor Type.

Subtype: Receptor SubType.

Species: Organism.

Orthosteric Ligand: Name of the orthosteric ligand, if present.

Other Ligand(s): Name of other allosteric ligands, if present.

Protein Partners: G Protein, Arrestin or Kinase coupled to a given receptor.

Resolution: Structure resolution.

Date: Deposition date.

DOI: DOI and link of the corresponding paper.

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ShowPDBClassSubFamilyTypeSubTypeSpeciesOrthosteric LigandOther Ligand(s)Protein PartnersResolutionDateDOI
9II3CAminoacidMetabotropic GlutamatemGlu3; mGlu3Homo sapiensGlutamate-Arrestin23.92025-03-05doi.org/10.1038/s41589-025-01858-8
9II2CAminoacidMetabotropic GlutamatemGlu3; mGlu3Homo sapiensGlutamate-Arrestin23.72025-03-05doi.org/10.1038/s41589-025-01858-8
8YJPCOrphanOrphanGPR156Homo sapiens---3.092025-02-05doi.org/10.1038/s41467-024-54681-5
8YK0COrphanOrphanGPR156Homo sapiens--Gi3/β1/γ22.42025-02-05doi.org/10.1038/s41467-024-54681-5
8Z74APeptideApelinApelinHomo sapiensAgonistic antibody--3.012025-01-2210.1038/s41467-024-55555-6
8XQJAPeptideApelinApelinHomo sapiensJN241--2.952025-01-22doi.org/10.1038/s41467-024-55555-6
8XQIAPeptideApelinApelinHomo sapiens---3.252025-01-22doi.org/10.1038/s41467-024-55555-6
8XQEAPeptideApelinApelinHomo sapiensApelin-13-Gi1/β1/γ23.482025-01-22doi.org/10.1038/s41467-024-55555-6
8Y69AOrphanOrphanLGR4Homo sapiensR-spondin-2CholesterolZNRF33.382024-12-04To be published
8WGDCAminoacidMetabotropic GlutamatemGlu4; mGlu2Homo sapiensWAG/WA6--4.452024-11-27To be published
8WGCCAminoacidMetabotropic GlutamatemGlu4; mGlu2Homo sapiensLY379268--5.952024-11-27To be published
8WG9CAminoacidMetabotropic GlutamatemGlu4; mGlu2Homo sapiens(2S)-2-amino-4-phosphonobutanoic acid--4.462024-11-27To be published
8WGBCAminoacidMetabotropic GlutamatemGlu4; mGlu2Homo sapiensGlutammateW9RGi3/β1/γ23.72024-10-30doi.org/10.1038/s41467-024-54744-7
9C2FCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Tryptophan; '6218; PO4-2.82024-10-0210.1126/science.ado1868
9C1PCIonCalcium SensingCaSHomo sapiensCaCa; Tryptophan; '6218; PO4-2.82024-10-0210.1126/science.ado1868
8IRJCOrphanOrphanGPR179Homo sapiens---3.492024-09-18To be published
8WM9FProteinFrizzledFZD4Homo sapiensDVL-2--3.532024-09-11doi.org/10.1038/s41467-024-52174-z
9IMACOrphanOrphanGPRC5DHomo sapiensTalquetamab--2.652024-09-11doi.org/10.1016/j.jmb.2024.168748
8TRDCAminoacidMetabotropic GlutamatemGlu3; mGlu3Rattus norvegicusLY341495--3.42024-07-31To be published
8TRCCAminoacidMetabotropic GlutamatemGlu3; mGlu3Rattus norvegicusLY341495--3.32024-07-3110.1101/2023.08.13.552748
8TR2CAminoacidMetabotropic GlutamatemGlu3; mGlu3Rattus norvegicusCa; LY379268Ca-3.52024-07-3110.1101/2023.08.13.552748
8TR0CAminoacidMetabotropic GlutamatemGlu3; mGlu3Rattus norvegicusLY341495--3.22024-07-3110.1101/2023.08.13.552748
8TQBCAminoacidMetabotropic GlutamatemGlu3; mGlu3Rattus norvegicusCa; PAM VU6023326Ca-3.32024-07-3110.1101/2023.08.13.552748
8YZKCOrphanOrphanGPRC5DHomo sapiens---3.42024-07-0310.1038/s41467-024-49625-y
8Z1EAOrphanOrphanUL78Human herpesvirus 5---3.122024-05-1510.1038/s41421-024-00684-x
9AXFCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4chim(NtGi1-Gs-CtGq)/β1/γ23.52024-04-1710.1038/s41586-024-07331-1
9ASBCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; 9IG; PO4chim(NtGi1-Gs-CtGq)/β1/γ23.42024-04-1710.1038/s41586-024-07331-1
9AVGCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; 9IG; PO4chim(NtGi1-Gs)/β1/γ23.62024-04-1710.1038/s41586-024-07331-1
9AYFCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4Gi1/β1/γ23.62024-04-1710.1038/s41586-024-07331-1
9AVLCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; 9IG; PO4Gi3/β2/γ23.82024-04-1710.1038/s41586-024-07331-1
8IEPCOrphanOrphanGPR156Homo sapiensA1LYA--2.612024-02-14doi.org/10.1038/s41594-024-01224-7
8IEICOrphanOrphanGPR156Homo sapiensA1LYA--2.622024-02-14doi.org/10.1038/s41594-024-01224-7
8IEBCOrphanOrphanGPR156Homo sapiensA1LYA--3.032024-02-14doi.org/10.1038/s41594-024-01224-7
8IEDCOrphanOrphanGPR156Homo sapiensA1LYA-Go/β1/γ23.332024-02-14doi.org/10.1038/s41594-024-01224-7
8SZFCIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-2.82024-02-0710.1038/s41586-024-07055-2
8SZGCIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCWchim(NtGi1-Gq)/β1/γ23.62024-02-0710.1038/s41586-024-07055-2
8SZHCIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCWGi1/β1/γ23.12024-02-0710.1038/s41586-024-07055-2
8SZICIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCWGi3/β1/γ23.52024-02-0710.1038/s41586-024-07055-2
8WPGCIonCalcium SensingCaSHomo sapiens-Tryptophan; Cinacalcet; PO4; Ca-2.72023-11-2210.1038/s41422-023-00892-2
8WPUCIonCalcium SensingCaSHomo sapiens-Tryptophan; Cinacalcet; PO4; Cachim(NtGi2L-Gs-CtGq)/β1/γ23.12023-11-2210.1038/s41422-023-00892-2
8JD2CAminoacidMetabotropic GlutamatemGlu2; mGlu3Homo sapiensGlutamate--2.82023-06-2110.1038/s41422-023-00830-2
8JD1CAminoacidMetabotropic GlutamatemGlu2; mGlu3Homo sapiensGlutamate--3.72023-06-2110.1038/s41422-023-00830-2
8JD0CAminoacidMetabotropic GlutamatemGlu2; mGlu3Homo sapiensGlutamateNAM563-3.32023-06-2110.1038/s41422-023-00830-2
8JCZCAminoacidMetabotropic GlutamatemGlu2; mGlu3Homo sapiensLY341495--32023-06-2110.1038/s41422-023-00830-2
8JCYCAminoacidMetabotropic GlutamatemGlu2; mGlu3Homo sapiensLY341495--2.92023-06-2110.1038/s41422-023-00830-2
8JCXCAminoacidMetabotropic GlutamatemGlu2; mGlu3Homo sapiensLY341495--32023-06-2110.1038/s41422-023-00830-2
8JCWCAminoacidMetabotropic GlutamatemGlu2; mGlu3Homo sapiensLY341495--32023-06-2110.1038/s41422-023-00830-2
8JCVCAminoacidMetabotropic GlutamatemGlu2; mGlu3Homo sapiensLY341495--3.42023-06-2110.1038/s41422-023-00830-2
8JCUCAminoacidMetabotropic GlutamatemGlu2; mGlu3Homo sapiensLY341495--2.82023-06-2110.1038/s41422-023-00830-2
8JD4CAminoacidMetabotropic GlutamatemGlu2; mGlu4Homo sapiensGlutamate--2.92023-06-2110.1038/s41422-023-00830-2
8JD3CAminoacidMetabotropic GlutamatemGlu2; mGlu3Homo sapiensGlutamateHZR; PEFGi1/β1/γ23.32023-06-2110.1038/s41422-023-00830-2
8JD5CAminoacidMetabotropic GlutamatemGlu2; mGlu4Homo sapiensGlutamateBQI; HZE; PEFGi1/β1/γ23.62023-06-2110.1038/s41422-023-00830-2
8JD6CAminoacidMetabotropic GlutamatemGlu4; mGlu4Homo sapiensPhosphoserineN-(3-chlorophenyl)pyridine-2-carboxamideGi3/β1/γ23.42023-06-2110.1038/s41422-023-00830-2
8X0HCAminoacidMetabotropic GlutamatemGlu5; mGlu5Homo sapiensQuisqualate--4.12024-11-06doi.org/10.1038/s41467-024-55439-9
8X0GCAminoacidMetabotropic GlutamatemGlu5; mGlu5Homo sapiensQuisqualate--32024-11-06doi.org/10.1038/s41467-024-55439-9
8X0FCAminoacidMetabotropic GlutamatemGlu5; mGlu5Homo sapiensQuisqualateVU0424465-3.32024-11-06doi.org/10.1038/s41467-024-55439-9
8X0ECAminoacidMetabotropic GlutamatemGlu5; mGlu5Homo sapiensQuisqualate--3.42024-11-06doi.org/10.1038/s41467-024-55439-9
8X0DCAminoacidMetabotropic GlutamatemGlu5; mGlu5Homo sapiensQuisqualateVU0424465-3.52024-11-06doi.org/10.1038/s41467-024-55439-9
8X0CCAminoacidMetabotropic GlutamatemGlu5; mGlu5Homo sapiensQuisqualateVU0424465-3.22024-11-06doi.org/10.1038/s41467-024-55439-9
8X0BCAminoacidMetabotropic GlutamatemGlu5; mGlu5Homo sapiensQuisqualateVU0424465-3.12024-11-06doi.org/10.1038/s41467-024-55439-9
8TAOCAminoacidMetabotropic GlutamatemGlu5; mGlu5Homo sapiensQuisqualateCDPPB-2.92023-10-1110.1101/2023.08.29.555158
8T8MCAminoacidMetabotropic GlutamatemGlu5; mGlu5Homo sapiensQuisqualate--32023-10-1110.1101/2023.08.29.555158
8T7HCAminoacidMetabotropic GlutamatemGlu5; mGlu5Homo sapiensQuisqualate--3.32023-10-1110.1101/2023.08.29.555158
8T6JCAminoacidMetabotropic GlutamatemGlu5; mGlu5Homo sapiens-CDPPB-3.52023-10-1110.1101/2023.08.29.555158
7W0NAPeptideApelinApelinHomo sapiensElabela-Gi1/β1/γ24.212022-07-2710.1038/s41594-022-00797-5
7W0LAPeptideApelinApelinHomo sapiensPubChem 122701908-Gi1/β1/γ23.572022-07-2710.1038/s41594-022-00797-5
7WIHCAminoacidMetabotropic GlutamatemGlu3; mGlu3Homo sapiensLY2794193--3.682022-03-1610.1038/s41422-022-00623-z
7WI8CAminoacidMetabotropic GlutamatemGlu3; mGlu3Homo sapiensLY341495--4.172022-03-1610.1038/s41422-022-00623-z
7WI6CAminoacidMetabotropic GlutamatemGlu3; mGlu3Homo sapiensLY341495--3.712022-03-1610.1038/s41422-022-00623-z
7QBID1Ste2-likeSTE2STE2Saccharomyces cerevisiaeα-factor mating pheromone--3.462022-03-1610.1038/s41586-022-04498-3
7QBCD1Ste2-likeSTE2STE2Saccharomyces cerevisiaeα-factor mating pheromone--3.532022-03-1610.1038/s41586-022-04498-3
7QB9D1Ste2-likeSTE2STE2Saccharomyces cerevisiae---3.12022-03-1610.1038/s41586-022-04498-3
7QA8D1Ste2-likeSTE2STE2Saccharomyces cerevisiaePeptide--2.72022-03-1610.1038/s41586-022-04498-3
7SINCIonCalcium SensingCaSHomo sapiens-NPS-2143-5.92022-01-1910.1073/pnas.2115849118
7SIMCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; PO4-2.72022-01-1910.1073/pnas.2115849118
7SILCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-2.72022-01-1910.1073/pnas.2115849118
7SHECOrphanOrphanGPR158Homo sapiens-PI; PE-3.42021-12-0110.1126/science.abl4732
7EWLCOrphanOrphanGPR158Homo sapiens---3.522021-12-0110.1038/s41467-021-27147-1
7SHFCOrphanOrphanGPR158Homo sapiens-PI; PEB5; RGS73.42021-12-0110.1126/science.abl4732
7EWRCOrphanOrphanGPR158Homo sapiens--B5; RGS74.72021-12-0110.1038/s41467-021-27147-1
7EWPCOrphanOrphanGPR158Homo sapiens--B5; RGS74.32021-12-0110.1038/s41467-021-27147-1
7E6UCIonCalcium SensingCaSHomo sapiens---62021-09-2210.7554/eLife.68578
7E6TCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; PO4-32021-09-2210.7554/eLife.68578
7DGECAminoacidMetabotropic GlutamatemGlu1; mGlu1Homo sapiensQuisqualate--3.652021-09-2210.1007/s13238-020-00808-5
7DGDCAminoacidMetabotropic GlutamatemGlu1; mGlu1Homo sapiens---3.962021-09-2210.1007/s13238-020-00808-5
7FD9CAminoacidMetabotropic GlutamatemGlu5; mGlu5Homo sapiensLY341495--42021-09-0810.1016/j.celrep.2021.109648
7FD8CAminoacidMetabotropic GlutamatemGlu5; mGlu5Homo sapiensQuisqualate--3.82021-09-0810.1016/j.celrep.2021.109648
7MTRCAminoacidMetabotropic GlutamatemGlu2; mGlu2Homo sapiensGlutamateADX55164-3.32021-07-0710.1038/s41586-021-03680-3
7MTQCAminoacidMetabotropic GlutamatemGlu2; mGlu2Homo sapiensLY341495--3.652021-07-0710.1038/s41586-021-03680-3
7MTSCAminoacidMetabotropic GlutamatemGlu2; mGlu2Homo sapiensGlutamateADX55164Gi1/β1/γ23.22021-07-0710.1038/s41586-021-03680-3
7M3JCIonCalcium SensingCaSHomo sapiens-NPS-2143; PO4-4.12021-06-3010.1038/s41586-021-03691-0
7M3GCIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4-2.52021-06-3010.1038/s41586-021-03691-0
7M3FCIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4-2.82021-06-3010.1038/s41586-021-03691-0
7M3ECIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; NPS-2143-3.22021-06-3010.1038/s41586-021-03691-0
7EPBCAminoacidMetabotropic GlutamatemGlu2; mGlu2Homo sapiensEglumetad--3.12021-06-2310.1038/s41586-021-03641-w
7EPACAminoacidMetabotropic GlutamatemGlu2; mGlu2Homo sapiens---3.62021-06-2310.1038/s41586-021-03641-w
7EPDCAminoacidMetabotropic GlutamatemGlu2, mGlu7Homo sapiens---3.92021-06-2310.1038/s41586-021-03641-w
7EPCCAminoacidMetabotropic GlutamatemGlu7; mGlu7Homo sapiens---42021-06-2310.1038/s41586-021-03641-w
7E9GCAminoacidMetabotropic GlutamatemGlu2; mGlu2Homo sapiensEglumetadJNJ-40411813Gi1/β1/γ23.52021-06-2310.1038/s41586-021-03495-2
7E9HCAminoacidMetabotropic GlutamatemGlu4; mGlu4Homo sapiensPhosphoserine-Gi3/β1/γ242021-06-2310.1038/s41586-021-03495-2
7DD7CIonCalcium SensingCaSGallus gallusCaCa; Ca; Tryptophan; Evocalcet-3.22021-06-1610.1126/sciadv.abg1483
7DD6CIonCalcium SensingCaSGallus gallusCaCa; Ca; Tryptophan-3.22021-06-1610.1126/sciadv.abg1483
7DD5CIonCalcium SensingCaSGallus gallusCaCa; Ca; Tryptophan; NPS-2143-3.22021-06-1610.1126/sciadv.abg1483
7EB2CAminoacidGABABGABAB2; GABAB1Homo sapiensBaclofenrac-BHFFGi1/β1/γ23.52021-05-0510.1038/s41586-021-03507-1
7DTWCIonCalcium SensingCaSHomo sapiens---4.52021-03-1010.1038/s41422-021-00474-0
7DTVCIonCalcium SensingCaSHomo sapiensCaCa; Tryptophan-3.52021-03-1010.1038/s41422-021-00474-0
7DTUCIonCalcium SensingCaSHomo sapiens-Tryptophan-4.42021-03-1010.1038/s41422-021-00474-0
7DTTCIonCalcium SensingCaSHomo sapiensCaCa-3.82021-03-1010.1038/s41422-021-00474-0
7AD3D1Ste2-likeSTE2STE2Saccharomyces cerevisiaeα-factor mating pheromone-Gi1/STE4/γ23.32020-12-0910.1038/s41586-020-2994-1
7CUMCAminoacidGABABGABAB1, GABAB2Homo sapiensCGP54626Phospholipid-3.522020-11-1110.1016/j.jmb.2020.09.023
7CA5CAminoacidGABABGABAB1, GABAB2Homo sapiens---7.62020-11-1110.1016/j.jmb.2020.09.023
7CA3CAminoacidGABABGABAB1, GABAB2Homo sapiens-rac-BHFF-4.52020-11-1110.1016/j.jmb.2020.09.023
6W2YCAminoacidGABABGABAB1; GABAB1Homo sapiensPubChem 5311042PubChem 23727970-3.22020-07-0110.1038/s41586-020-2469-4
7C7SCAminoacidGABABGABAB1, GABAB2Homo sapiensCGP54626--2.92020-07-0110.1038/s41422-020-0350-5
7C7QCAminoacidGABABGABAB1, GABAB2Homo sapiensBaclofenPubChem 7023848-32020-07-0110.1038/s41422-020-0350-5
6WIVCAminoacidGABABGABAB1, GABAB2Homo sapiens-PubChem 52923113; PubChem 52924645-3.32020-07-0110.1038/s41586-020-2452-0
6W2XCAminoacidGABABGABAB1, GABAB2Homo sapiensPubChem 5311042PubChem 23727970-3.62020-07-0110.1038/s41586-020-2469-4
6VJMCAminoacidGABABGABAB1, GABAB2Homo sapiens---3.972020-06-1010.1038/s41586-020-2408-4
6UOACAminoacidGABABGABAB1, GABAB2Homo sapiens---6.32020-06-1010.1038/s41586-020-2408-4
6UO9CAminoacidGABABGABAB1, GABAB2Homo sapiensSKF97541--4.82020-06-1010.1038/s41586-020-2408-4
6UO8CAminoacidGABABGABAB1, GABAB2Homo sapiensSKF97541GS39783-3.632020-06-1010.1038/s41586-020-2408-4
6N52CAminoacidMetabotropic GlutamatemGlu5; mGlu5Homo sapiens---42019-01-2310.1038/s41586-019-0881-4
6N51CAminoacidMetabotropic GlutamatemGlu5; mGlu5Homo sapiensQuisqualate--42019-01-2310.1038/s41586-019-0881-4
4OR2CAminoacidMetabotropic GlutamatemGlu1; mGlu1Homo sapiens-FITM-2.82014-03-1910.1126/science.1249489