Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
11x36 4.805406
21x53 3.2425408
32x41 2.95406
42x42 6.23407
52x44 6.5925406
62x56 3.2025427
72x57 6.435427
82x60 7.535425
92x64 6.4925424
10E1x50 6.65833628
11E1x52 8.266527
123x34 6.8754125
133x37 4.03407
143x40 2.76427
153x51 7.7575408
16I2x57 6.058336166
174x50 7.2485129
18E2x50 5.6425429
19E2x52 4424
20E2.F202 6.07333606
215x34 4.6854173
225x40 8.505425
235x44 5.7375425
245x47 5.194528
255x58 6.7925158
26I3.L245 3.78403
27I3.L246 5.11502
286x44 5.2475429
296x48 5.82833628
306x52 4.1375427
317x35 5.994524
327x42 9.5525427
337x49 5.7409
347x51 3.5175406
358x50 6.0825408
36Lig 11.862020
37G.HN.43 3.925479
38G.HN.47 3.09667676
39G.S1.02 4.77545
40G.S1.04 4.45447
41G.S1.06 7.635448
42G.S1.07 4.48419
43G.s1h1.06 2.6575409
44G.H1.01 5.835449
45G.S2.01 3.845419
46G.S3.01 4.5075444
47G.S3.03 7.562547
48G.S3.04 8.296516
49G.S3.05 3.9275407
50G.S3.06 6.466515
51G.H2.02 4.335418
52G.H2.03 5.11419
53G.H2.06 5.85167619
54G.H2.07 6.672519
55G.h2s4.01 4.89571719
56G.S4.02 5.3675418
57G.S4.03 4.3547
58G.S4.04 5.225609
59G.H3.01 8.05409
60G.H3.09 6.715409
61G.H3.15 5.23418
62G.H3.17 7.19167615
63G.H3.18 8.1975419
64G.S5.03 4.346548
65G.S5.05 4.14857749
66G.S5.06 4.64408
67G.S5.07 4.17409
68G.HG.04 5.08667689
69G.HG.15 5.0875487
70G.hgh4.02 3.684507
71G.hgh4.05 9.1075407
72G.H4.03 3.965484
73G.H4.15 3.325608
74G.h4s6.02 6.44254188
75G.h4s6.12 4.6475444
76G.S6.02 6.765647
77G.S6.03 5.7354195
78G.s6h5.01 5.66449
79G.H5.03 6.5975448
80G.H5.08 6.974548
81G.H5.26 3.4725405
82b.h2x5 4.09254105
83b.lhb1x3 3.11254102
84b.lhb1x6 5.72254103
85b.lhb1x11 3.9125404
86b.b1x3 4.35754217
87b.l1x3 7.12286779
88b.b2x5 6.0256117
89b.b4x2 6.05408
90b.b4x4 7.76478
91b.b4x6 9.18667679
92b.l4x2 4.724224
93b.b5x2 5.92407
94b.b5x3 6.175679
95b.b5x5 5.044235
96b.b5x7 5.3175497
97b.l5x1 6.036598
98b.l5x5 6.70571719
99b.b6x5 4.38333606
100b.l6x5 6.8875414
101b.b7x1 6.132514
102b.b8x3 3.19516
103b.b8x4 5.415696
104b.b9x2 3.0775415
105b.l9x3 6.01429719
106b.l9x6 5.88833618
107b.b10x5 5.21833619
108b.b11x6 6.325419
109b.l11x1 3.8419
110b.l11x2 8.48419
111b.b12x6 7.06143718
112b.l12x1 2.725416
113b.b13x7 6.738567
114b.l13x3 7.15667669
115b.l13x6 5.36519
116b.b15x1 5.716569
117b.b15x2 5.5025436
118b.l15x1 5.045617
119b.l15x2 5.425469
120b.b16x4 9.51466
121b.b16x5 5.165435
122b.b16x6 8.51167668
123b.b16x7 8.5175439
124b.b17x5 7.22537
125b.b17x7 7.385438
126b.l17x3 7.20375839
127b.l17x6 6.24419
128b.b18x3 4.3225438
129b.l18x1 7.73833656
130b.b19x2 4.54429736
131b.b19x4 5.784538
132b.l19x2 7.6475439
133b.b20x2 5.68536
134b.b20x4 11.095438
135b.b20x6 6.592536
136b.b20x7 4.905409
137b.l20x2 5.8375409
138b.b21x1 11.225437
139b.b21x5 4.995454
140b.b21x7 3.93429755
141b.l21x5 3.3175454
142b.b22x5 5.52333657
143b.l22x5 6.6465109
144b.b23x1 4.7175405
145b.b23x6 6.04714757
146b.l23x1 7.4406
147b.b24x4 5.662556
148b.b24x6 4.0175458
149b.l24x2 4.845406
150b.b25x3 4.44455
151b.l25x3 9.3485149
152b.l26x5 5.735405
153b.l27x1 10.235619
154b.l27x2 8.32754149
155b.b28x3 4.062577
156b.b28x4 6.4975406
157b.b28x6 10.09409
158g.h1x11 3.37509
159g.l1x4 6.77638
160g.h2x9 2.6154104
161g.ctx3 5.81333609
162g.ctx6 2.998336106
163g.ctx15 4.6525409
164g.ctx16 3.862508
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
12x60 Lig 54.243110.54YesYes250
22x57 2x60 56.74592.66YesYes275
31x43 2x57 62.5246.35NoYes067
41x43 1x47 63.15033.17NoNo066
51x47 2x54 63.46327.37NoNo066
62x54 7x47 63.7767.99NoNo067
71x50 7x47 64.40122.98NoNo097
81x50 7x51 65.02572.96NoYes096
91x53 7x51 66.16834.81YesYes086
101x53 1x57 69.3813.07YesNo087
111x57 2x44 75.24565.02NoYes076
122x44 I1x50 75.9258.71YesNo067
132x41 I1x50 76.23072.92YesNo067
142x41 4x46 77.762.83YesNo067
152x42 4x46 82.50219.3YesNo077
162x42 3x49 88.24079.2YesNo078
173x49 I2x57 88.541211.91NoYes086
186x52 Lig 11.76833.27YesYes270
19G.H5.19 I2x57 90.91953.62NoYes1686
20G.H5.15 G.H5.19 91.53872.83NoNo078
21G.H5.11 G.H5.15 92.6923.07NoNo087
22G.H5.11 G.S1.02 46.17044.81NoYes485
23G.H5.11 G.S3.03 46.81815.24NoYes487
24G.S1.02 G.S1.04 48.21082.98YesYes457
25G.S1.04 G.S4.03 49.18445.71YesYes477
26G.S1.04 G.S3.03 48.04934.87YesYes477
27G.S1.04 G.S3.05 47.22254.24YesYes077
28G.S1.06 G.S3.05 47.4637.07YesYes087
29G.H1.01 G.S1.06 98.20167.05YesYes498
30G.H1.01 G.s1h1.01 98.32083.49YesNo099
31G.S4.04 G.s1h1.01 1004.52YesNo099
32G.S1.07 G.S4.04 93.40622.44YesYes099
33G.S1.05 G.S1.07 51.60416.92NoYes199
34G.S1.05 G.h2s4.01 51.69099.74NoYes199
35G.h2s4.01 b.l5x5 37.38529.02YesYes199
36G.S1.06 G.S4.03 50.97892.85YesYes487
37G.S1.07 G.S4.02 21.75622.85YesYes198
38G.H3.12 G.S1.07 20.10795.71NoYes089
39G.H2.07 G.h2s4.01 27.89844.01YesYes199
40G.H2.04 G.H3.12 19.9967.52NoNo098
41G.H2.04 G.H2.07 19.8735NoYes099
42G.H2.02 G.H2.07 47.20764.94YesYes189
43G.H2.02 b.l9x6 27.30885.09YesYes188
44G.H2.02 b.l13x6 27.30884.42YesYes189
45G.H3.18 G.S4.02 21.654411.3YesYes198
46G.H3.15 G.H3.18 21.39384.83YesYes189
47G.H2.10 b.l5x5 10.13642.61NoYes079
48G.H2.09 G.H2.10 10.22274.42NoNo087
49G.H3.15 G.H3.17 21.24099.04YesYes185
50G.S4.04 G.S4.06 11.36373.93YesNo097
51G.S4.04 G.S5.04 13.12963.65YesNo099
52G.H4.15 G.S4.06 11.05332.62YesNo087
53G.H4.15 G.S5.04 11.05153.65YesNo089
54G.H3.17 b.l25x6 19.26356YesNo158
55G.HG.15 G.hgh4.05 11.54718.21YesYes077
56b.l5x3 b.l5x5 28.37232.47NoYes089
57b.l5x3 b.l7x3 28.220510.31NoNo089
58b.l7x3 b.l7x5 28.07242.8NoNo096
59b.b9x3 b.l7x5 27.79832.73NoNo066
60b.b9x3 b.l8x10 27.51762.85NoNo964
61b.b8x4 b.l8x10 27.42596.31YesNo964
62b.b7x2 b.b8x4 26.73953.79NoYes086
63b.b6x5 b.b7x2 26.3632.52YesNo068
64b.b2x4 b.b6x5 28.3894.36NoYes066
65b.b10x4 b.b2x4 28.23657.9NoNo066
66b.b10x4 b.b14x5 26.93913.64NoNo065
67b.b14x5 b.b15x1 26.15922.44NoYes059
68b.b15x1 b.b16x6 24.756111.02YesYes698
69b.b16x4 b.b16x6 22.68766.96YesYes668
70b.b16x4 b.b17x6 22.699810.51YesNo067
71b.b17x6 g.h1x14 22.54158.47NoNo079
72g.h1x11 g.h1x14 22.38312.65YesNo099
73b.1x15 g.h1x11 19.66742.85NoYes079
74b.1x15 g.l1x4 11.53426.26NoYes378
75b.l23x1 b.l25x6 23.510920.25YesNo068
76b.l21x7 b.l23x1 17.87813.11NoYes056
77b.b23x6 b.l21x7 17.08184.03YesNo575
78b.b23x6 b.b24x6 14.56375.79YesYes578
79b.b21x7 b.b24x6 14.08112.89YesYes558
80b.l11x1 b.l9x6 24.53544.35YesYes198
81b.b11x6 b.l11x1 45.32813.71YesYes199
82b.b11x6 b.l9x3 38.40749.76YesYes199
83b.b12x6 b.l9x3 33.41348.46YesYes189
84b.b11x2 b.b12x6 29.03082.35NoYes178
85b.b10x5 b.b11x2 13.885912.56YesNo197
86b.l11x1 b.l13x6 24.53545.03YesYes199
87b.b7x1 b.b8x3 16.42493.63YesYes146
88b.b11x2 b.l12x1 14.5172.94NoYes176
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
1x352x6412.092NoYes5422
1x357x352.652NoYes5421
1x397x3513.070NoYes7421
1x397x386.040NoNo7521
2x562x605.672YesYes7521
2x567x422.52YesYes7722
2x572x602.662YesYes7521
2x577x4215.242YesYes7722
2x59E1x529.652NoYes6722
2x593x283.932NoNo6521
2x607x4211.272YesYes5712
2x60Lig10.542YesYes5010
2x63E1x504.642NoYes4811
2x63Lig15.22NoYes4010
2x647x358.712YesYes4421
E1x50E1x5217.042YesYes8712
3x21E1x502.810NoYes7821
3x25E1x503.922NoYes9821
E1x50E2x506.532YesYes8911
E1x50Lig5.012YesYes8010
3x25E2x507.282NoYes9921
3x28Lig2.622NoYes5010
3x29E2x503.172NoYes5911
3x29E2x522.772NoYes5411
3x29Lig4.872NoYes5010
3x334x6012.092NoNo5412
3x33Lig13.682NoYes5010
3x363x373.732NoYes8712
3x366x485.822NoYes8812
3x36Lig8.382NoYes8010
3x375x432.620YesNo7521
4x60E2x524.280NoYes4421
E2.R192E2.V19710.460NoNo1421
E2.R192E3.R29111.730NoNo1122
E2.V197Lig3.682NoYes4010
E2x50Lig5.592YesYes9010
E2.F202E2x523.650YesYes6421
E2x52Lig5.32YesYes4010
5x36E2.F20214.332NoYes4622
5x365x408.32NoYes4521
5x366x592.892NoNo4422
5x406x554.552YesNo5611
5x406x599.012YesNo5412
5x40Lig12.162YesYes5010
5x43Lig5.052NoYes5010
5x445x479.652YesYes5822
5x446x525.662YesYes5721
5x476x523.392YesYes8721
6x486x524.232YesYes8721
6x516x553.070NoNo5621
6x52Lig3.272YesYes7010
6x547x302.620NoNo5522
6x547x349.740NoNo5521
6x55Lig4.042NoYes6010
6x58E3.R29152NoNo4112
6x587x302.452NoNo4512
6x58Lig6.132NoYes4010
7x317x352.770NoYes4421
7x347x384.282NoNo5511
7x34Lig5.962NoYes5010
7x35Lig2.772YesYes4010
7x38Lig10.252NoYes5010

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
88.89Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
68.18Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
66.67Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
65.22Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
65.22Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
65.00Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
63.64Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
63.16Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
63.16Single8Y73Peptide8Y73-μ-Peptide-MPAM-15-Gi1/β1/γ2
62.50Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
61.90Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
60.87Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
59.09Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
57.89Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
57.69Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
57.69Single9KDFRES-701-39KDF-ETB-RES-701-3
57.14Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
55.00Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
55.00Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
55.00Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
55.00Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
55.00Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
55.00Consensuslpa_onOrthosteric Ligandlpa1_on
55.00Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
54.55Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
54.55Single8Y72Peptide8Y72-μ-Peptide-BMS-986122-Gi1/β1/γ2
54.55Single9IZASCH9002719IZA-HCA2-SCH900271-Gi1/β1/γ2
54.17Single6PT2KGCHM076PT2-δ-KGCHM07
54.17Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
54.17Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
52.38Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
52.38Single8JJLOlodaterol8JJL-β2-Olodaterol
52.38Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
52.38Single9M4QDoxazosin9M4Q-Alpha1A-Doxazosin
52.38Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
52.38Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
52.17Single8PKMBefiradol8PKM-5-HT1A-Befiradol-Gi1/β1/γ1
52.17Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
52.17Consensuslpl_onOrthosteric Ligands1p_on lpa_on
52.17Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
52.17Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
52.17Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
51.85Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
50.00Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
50.00Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
50.00Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
50.00Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
50.00Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
50.00Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
50.00Single8WGBVU01550418WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
50.00Single8ZRTET-18ZRT-ETB-ET-1
50.00Single9I52A1IZU9I52-D1-A1IZU-Gs/β1/γ2
50.00Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
50.00Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
50.00Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
50.00Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
50.00Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
50.00Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
50.00Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
48.00Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
48.00Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
48.00Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
48.00Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
47.83Single9IPVJR14a9IPV-C3aB-JR14a-Gi1/β1/γ2
47.83Single9M0RNeuropeptide VF9M0R-NPFF1-Neuropeptide VF-Gi1/β1/γ2
47.62Single3P0GBI1671073P0G-β2-BI167107
47.62Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
47.62Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
47.62Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
47.62Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
47.62Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
47.62Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
47.62Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
47.62Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
47.62Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
47.62Single8ZWFJR14a8ZWF-C3aB-JR14a
47.62Single9I54A1IZV9I54-D1-A1IZV-Gs/β1/γ2
47.37Single8K9LDamgo8K9L-μ-Damgo-BMS-986122-Gi3/β1/γ1
46.15Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
46.15Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
45.83Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
45.83Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
45.83Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
45.83Single9BUYLM1899BUY-β2-LM189-Gi1/β1/γ2
45.83Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
45.83Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
45.45Single4LDEBI1671074LDE-β2-BI167107
45.45Single4RWADIPP-NH24RWA-δ-DIPP-NH2
45.45Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
45.45Single6MXTSalmeterol6MXT-β2-Salmeterol
45.45Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
45.45Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
45.45Single7YITNalfurafine7YIT-κ-Nalfurafine
45.45Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
45.45Single8JJ8Formoterol8JJ8-β2-Formoterol
45.45Single8JWY2-1188JWY-A2A-2-118
45.45Single8JWZAB9288JWZ-A2A-AB928-Na
45.45Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
45.45Single9GL2Befiradol9GL2-5-HT1A-Befiradol-Gs/β1/γ2
45.45Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
45.45Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
45.00Single5DHHSB-6121115DHH-NOP-SB-612111
45.00Single5UIGCmpd-15UIG-A2A-Cmpd-1
45.00Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
45.00Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
45.00Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
45.00Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
45.00Single9H37A1IR09H37-A2A-A1IR0-Na
45.00Consensusa3_onOrthosteric Liganda3a_on
44.44Single9JFYhNPSF9JFY-NPFF2-hNPSF-Gi1/β1/γ2
44.00Single3QAKUK-4320973QAK-A2A-UK-432097
44.00Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
44.00Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
44.00Single9J0FNADH9J0F-P2Y14-NADH-Gi1/β1/γ2
44.00Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
44.00Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
43.48Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
43.48Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
43.48Single6H7LDobutamine6H7L-β1-Dobutamine
43.48Single7EZCUKA7EZC-A2A-UKA
43.48Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
43.48Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
43.48Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
43.48Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
43.48Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
43.48Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
43.48Single8ZPLHF511168ZPL-CXCR4-HF51116
43.48Single8ZWGJR14a8ZWG-C3aB-JR14a-Gi1/β1/γ2
43.48Single9M54Neuropeptide VF9M54-NPFF2-Neuropeptide VF-Gi1/β1/γ2
43.48Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
43.48Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
43.48Consensuscck_onOrthosteric Ligandccka_on cckb_on
43.48Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
43.48Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
43.48Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
42.86Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
42.86Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
42.86Single6E67BI1671076E67-β2-BI167107-Gs(CT)
42.86Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
42.86Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
42.86Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
42.86Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
42.86Single8GNEKW-63568GNE-A2A-KW-6356-Na
42.86Single8JXSPF-61428JXS-D1-PF-6142
42.86Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
42.86Consensusa3_on_gpOrthosteric Liganda3a_on_gp
42.86Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
42.86Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
42.86Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
42.86Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
42.86Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
42.31Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
42.31Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
42.31Consensusangiotensin_onOrthosteric Ligandat1_on
42.31Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
42.31Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
42.11Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
41.94Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
41.67Single3NY9ICI118-5513NY9-β2-ICI118-551
41.67Single5WF6UK-4320975WF6-A2A-UK-432097
41.67Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
41.67Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
41.67Single8QJ2pN1628QJ2-MC4-pN162-Gs
41.67Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
41.67Single8X5YAstemizole8X5Y-H1-Astemizole
41.67Single9IPYJR14a9IPY-C3aB-JR14a
41.67Single9MD1Buspirone9MD1-5-HT1A-Buspirone-Gz/β1/γ2
41.67Single9V2NMacimorelin9V2N-Ghrelin-Macimorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
41.38Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
41.38Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
41.38Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
41.38Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
41.38Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
40.91Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
40.91Single4DJHJDTic4DJH-κ-JDTic
40.91Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
40.91Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
40.91Single6H7JIsoprenaline6H7J-β1-Isoprenaline
40.91Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
40.91Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
40.91Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
40.91Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
40.91Single7TUYGSK682753A7TUY-GPR183-GSK682753A
40.91Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
40.91Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
40.91Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
40.91Single8E0GBU728E0G-μ-BU72
40.91Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
40.91Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
40.91Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
40.91Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
40.91Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
40.91Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
40.91Single9UY3Anamorelin9UY3-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
40.91Consensusa2_onOrthosteric Liganda2b_on
40.91Consensusa2_on_gpOrthosteric Liganda2b_on_gp
40.91Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
40.91Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
40.91Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
40.91Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
40.91Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
40.91Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
40.91Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
40.91Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
40.91Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
40.91Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
40.74Single6JODAngiotensin II6JOD-AT2-Angiotensin II
40.74Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
40.74Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
40.74Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
40.74Single8ZBISomatostatin-148ZBI-SST3-Somatostatin-14-Gi1/β1/γ2
40.74Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
40.74Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
40.74Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
40.74Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
40.62Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
40.00Single4IARErgotamine4IAR-5-HT1B-Ergotamine
40.00Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
40.00Single5IUBQ274563445IUB-A2A-Q27456344-Na
40.00Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
40.00Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
40.00Single6AQFZM-2413856AQF-A2A-ZM-241385
40.00Single6IGLIRL16206IGL-ETB-IRL1620
40.00Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
40.00Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
40.00Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
40.00Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
40.00Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
40.00Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
40.00Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
40.00Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
40.00Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
40.00Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
40.00Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
40.00Single8WDTphotoNECA8WDT-A2A-photoNECA
40.00Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
40.00Single9HB3Mambaquaretin-19HB3-V2-Mambaquaretin-1
40.00Single9J0IUDP-Glucuronic acid9J0I-P2Y14-UDP-Glucuronic acid-Gi1/β1/γ2
40.00Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
40.00Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
40.00Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
39.39Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
39.29Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
39.29Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
39.29Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
39.29Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
39.29Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
39.13Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
39.13Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
39.13Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
39.13Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
39.13Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
39.13Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
39.13Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
39.13Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
39.13Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
39.13Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
39.13Single9DGIZ85267113509DGI-CB1-Z8526711350
39.13Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
39.13Consensusalpha1_offOrthosteric Ligandalpha1a_off
39.13Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
39.13Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
39.13Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
39.13Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
39.13Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
39.13Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
39.13Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
39.13Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
39.13Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
39.13Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
38.71Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
38.71Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
38.71Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
38.71Consensusbombesin_onOrthosteric Ligandbb2_on
38.71Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
38.71Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
38.71Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
38.71Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
38.46Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
38.46Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
38.46Single9E82SDF-1-beta9E82-ACKR3-SDF-1-β-Arrestin2
38.46Single9IQSMuscarinic toxin 39IQS-M4-Muscarinic toxin 3
38.46Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
38.46Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
38.46Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
38.10Single2Y04Salbutamol2Y04-β1-Salbutamol
38.10Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
38.10Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
38.10Single5DHGC-355DHG-NOP-C-35
38.10Single5IU8Q274563475IU8-A2A-Q27456347-Na
38.10Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
38.10Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
38.10Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
38.10Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
38.10Single7PYRPSB-21157PYR-A2A-PSB-2115
38.10Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
38.10Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
38.10Single7UL4Alvimopan7UL4-μ-Alvimopan
38.10Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
38.10Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
38.10Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
38.10Single8CU6LJ-45178CU6-A2A-LJ-4517
38.10Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
38.10Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
38.10Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
38.10Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
38.10Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
38.10Single9CHXS-Carazolol9CHX-β2-S-Carazolol
38.10Consensus5ht5_onOrthosteric Ligand5ht5a_on
38.10Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
38.10Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
37.93Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
37.93Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
37.50Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
37.50Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
37.50Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
37.50Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
37.50Single5X93K-87945X93-ETB-K-8794
37.50Single6IBLArformoterol6IBL-β1-Arformoterol
37.50Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
37.50Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
37.50Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
37.50Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
37.50Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
37.50Single8S2TIsoprenaline8S2T-β1-Isoprenaline-chim(NtGi1-Gs)/β1/γ2
37.50Single9DYEBuspirone9DYE-5-HT1A-Buspirone-Go/β1/γ2
37.50Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
37.50Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
37.50Consensusendothelin_offOrthosteric Ligandetb_off
37.50Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
37.50Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
37.50Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
37.50Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
37.50Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
37.50Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
37.04Single5WF5UK-4320975WF5-A2A-UK-432097
37.04Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
37.04Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
37.04Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
37.04Single9M1OMorphine-Modulating Neuropeptide B9M1O-NPFF2-Morphine-Modulating Neuropeptide B-Gi1/β1/γ2
37.04Single9U4WGonadoliberin-19U4W-GnRH1-Gonadoliberin-1-chim(NtGi1L-Gs-CtGq)/β1/γ2
37.04Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
37.04Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
37.04Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
37.04Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
37.04Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
36.84Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
36.67Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
36.67Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
36.67Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
36.67Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
36.67Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
36.67Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
36.36Single2Y00Dobutamine2Y00-β1-Dobutamine
36.36Single2Y03Isoprenaline2Y03-β1-Isoprenaline
36.36Single5C1MBU725C1M-μ-BU72
36.36Single5IUAQ274563485IUA-A2A-Q27456348-Na
36.36Single5JQHS-Carazolol5JQH-β2-S-Carazolol
36.36Single5N2SPSB365N2S-A1-PSB36
36.36Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
36.36Single5TVNLSD5TVN-5-HT2B-LSD
36.36Single5WIUNemonapride5WIU-D4-Nemonapride
36.36Single5WIVNemonapride5WIV-D4-Nemonapride-Na
36.36Single5X7DS-Carazolol5X7D-β2-S-Carazolol-Cmpd-15
36.36Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
36.36Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
36.36Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
36.36Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
36.36Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
36.36Single6S0QZM-2413856S0Q-A2A-ZM-241385
36.36Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
36.36Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
36.36Single7C61Ergotamine7C61-5-HT1B-Ergotamine
36.36Single7LD3Adenosine7LD3-A1-Adenosine-MIPS521-Gi2/β1/γ2
36.36Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
36.36Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
36.36Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
36.36Single7WC6LSD7WC6-5-HT2A-LSD
36.36Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
36.36Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
36.36Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
36.36Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
36.36Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
36.36Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
36.36Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
36.36Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
36.36Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
36.36Single8QOTNanobody-E8QOT-μ-Nanobody-E
36.36Single8TF5Oleic acid8TF5-GPR6-Oleic acid
36.36Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
36.36Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
36.36Single9EHSLUF76029EHS-A3A-LUF7602
36.36Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
36.36Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
36.36Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
36.36Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
36.36Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
36.36Consensusadenosine_offOrthosteric Liganda1_off a2_off
36.36Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
36.36Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
36.36Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
36.36Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
36.36Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
36.36Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
36.36Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
36.36Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
36.36Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
36.36Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
36.00Single4UG2CGS216804UG2-A2A-CGS21680
36.00Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
36.00Single6PT3DPI-2876PT3-δ-DPI-287
36.00Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
36.00Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
36.00Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
36.00Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
36.00Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
36.00Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
36.00Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
35.71Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
35.71Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
35.71Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
35.71Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
35.71Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
35.48Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
35.48Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
35.48Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
35.48Consensusbradykinin_onOrthosteric Ligandbk2_on
35.48Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
35.48Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
35.48Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
35.48Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
35.00Single3PWHZM-2413853PWH-A2A-ZM-241385
35.00Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
35.00Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
35.00Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
35.00Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
35.00Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
35.00Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
35.00Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
35.00Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
35.00Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
35.00Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
35.00Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
35.00Single8YYWAlpha-ketoglutarate8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
35.00Single9H2XA1IR19H2X-A2A-A1IR1-Na
35.00Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
34.78Single2YDVNECA2YDV-A2A-NECA
34.78Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
34.78Single4UHRCGS216804UHR-A2A-CGS21680
34.78Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
34.78Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
34.78Single5G53NECA5G53-A2A-NECA-Gs
34.78Single6J21Aprepitant6J21-NK1-Aprepitant
34.78Single6WGTLSD6WGT-5-HT2A-LSD
34.78Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
34.78Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
34.78Single7FEECP559407FEE-CB1-CP55940-ZCZ011
34.78Single7PX4PSB-21137PX4-A2A-PSB-2113
34.78Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
34.78Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
34.78Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
34.78Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
34.78Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
34.78Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
34.78Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
34.78Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
34.78Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
34.78Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
34.78Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
34.78Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
34.78Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
34.78Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
34.78Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
34.78Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
34.78Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
34.78Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
34.78Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
34.78Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
34.78Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
34.78Single8XVLZibotentan8XVL-ETA-Zibotentan
34.78Single9BJKNaloxone9BJK-μ-Naloxone-NAM
34.78Single9EGOYVF9EGO-CB1-YVF-Gi1/β1/γ2
34.78Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
34.78Single9JMCDS-3801b9JMC-Motilin-DS-3801b-chim(Gs-CtGq)/β1/γ2
34.78Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
34.78Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
34.78Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
34.78Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
34.78Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
34.78Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
34.78Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
34.78Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
34.78Consensusrelaxin_onOrthosteric Ligandrxfp4_on
34.78Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
34.62Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
34.62Single4XT1Fractalkine4XT1-US28-Fractalkine
34.62Single7F8XNN90567F8X-CCKA-NN9056
34.62Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
34.62Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
34.62Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
34.62Single9M4TSilodosin9M4T-Alpha1A-Silodosin
34.62Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
34.48Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
34.48Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
34.48Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
34.48Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
34.48Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
34.48Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
34.48Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
34.48Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
34.48Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
34.48Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
34.48Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
34.38Single5GLHEndothelin-15GLH-ETB-Endothelin-1
34.38Single6IGKEndothelin-36IGK-ETB-Endothelin-3
34.38Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
34.38Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
34.38Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
34.38Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
33.33Single3REYXAC3REY-A2A-XAC
33.33Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
33.33Single4AMIBucindolol4AMI-β1-Bucindolol
33.33Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
33.33Single4PY02MeSATP4PY0-P2Y12-2MeSATP
33.33Single4XT3Fractalkine4XT3-US28-Fractalkine
33.33Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
33.33Single5IU7Q274563465IU7-A2A-Q27456346-Na
33.33Single5JTBZM-2413855JTB-A2A-ZM-241385
33.33Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
33.33Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
33.33Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
33.33Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
33.33Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
33.33Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
33.33Single6IQLL7458706IQL-D4-L745870
33.33Single6KQICP559406KQI-CB1-CP55940-Org27569
33.33Single6OS2TRV0266OS2-AT1-TRV026
33.33Single6PS0S-Carazolol6PS0-β2-S-Carazolol
33.33Single6PS4ICI118-5516PS4-β2-ICI118-551
33.33Single6PS5S-Propranolol6PS5-β2-S-Propranolol
33.33Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
33.33Single6TPGEMPA6TPG-OX2-EMPA
33.33Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
33.33Single6VI4JDTic6VI4-κ-JDTic
33.33Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
33.33Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
33.33Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
33.33Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
33.33Single6ZG9GSK10347026ZG9-M1-GSK1034702
33.33Single7AROLUF58337ARO-A2A-LUF5833-Na
33.33Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
33.33Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
33.33Single7F61PF-036547467F61-H3-PF-03654746
33.33Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
33.33Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
33.33Single7T32ZM-2413857T32-A2A-ZM-241385
33.33Single7T94LY21196207T94-M2-Acetylcholine-LY2119620-chim(NtGi1-Go)/β1/γ2
33.33Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
33.33Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
33.33Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
33.33Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
33.33Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
33.33Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
33.33Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
33.33Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
33.33Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
33.33Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
33.33Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
33.33Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single8IHKAcifran8IHK-HCA3-Acifran
33.33Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
33.33Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
33.33Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
33.33Single8K5CAcipimox8K5C-HCA2-Acipimox
33.33Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
33.33Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
33.33Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
33.33Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
33.33Single8Y6YGLPG09748Y6Y-FFA2-GLPG0974
33.33Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
33.33Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
33.33Single9JMDAzithromycin9JMD-Motilin-Azithromycin-chim(Gs-CtGq)/β1/γ2
33.33Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
33.33Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
33.33Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
33.33Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
33.33Consensusa2_offOrthosteric Liganda2a_off
33.33Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
33.33Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
33.33Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
33.33Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
33.33Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
33.33Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
33.33Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
33.33Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
33.33Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
33.33Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
33.33Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
33.33Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
33.33Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
33.33Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
33.33Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
33.33Consensuslpa_offOrthosteric Ligandlpa1_off
33.33Consensuslpl_offOrthosteric Ligands1p_off lpa_off
33.33Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
33.33Consensusorexin_onOrthosteric Ligandox2_on
32.26Single8W8XBeta-MSH8W8X-MC3-β-MSH-Ca-Gs/β1/γ2
32.14Single3OE0CVX153OE0-CXCR4-CVX15
32.14Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
32.14Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
32.14Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
32.14Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
32.00Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
32.00Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
32.00Single6K1QIRL25006K1Q-ETB-IRL2500
32.00Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
32.00Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
32.00Single7UM4AS26747237UM4-5-HT5A-AS2674723
32.00Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
32.00Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
32.00Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
32.00Single8T3OTUG-8918T3O-FFA4-TUG-891-chim(NtGi2L-Gs-CtGq)/β1/γ2
32.00Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
32.00Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
32.00Single9CGJC6-Quino9CGJ-δ-C6-Quino-Gi1/β1/γ2
32.00Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
32.00Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
32.00Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
32.00Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
32.00Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
31.82Single2Y01Dobutamine2Y01-β1-Dobutamine
31.82Single2Y02Carmoterol2Y02-β1-Carmoterol
31.82Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
31.82Single3EMLZM-2413853EML-A2A-ZM-241385
31.82Single3NY8ICI118-5513NY8-β2-ICI118-551
31.82Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
31.82Single4EJ4Naltrindole4EJ4-δ-Naltrindole
31.82Single4GBRS-Carazolol4GBR-β2-S-Carazolol
31.82Single4QKX35V4QKX-β2-35V
31.82Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
31.82Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
31.82Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
31.82Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
31.82Single5UENDU1725UEN-A1-DU172
31.82Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
31.82Single6H7MSalbutamol6H7M-β1-Salbutamol
31.82Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
31.82Single6PS1Timolol6PS1-β2-Timolol
31.82Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
31.82Single6S0LZM-2413856S0L-A2A-ZM-241385
31.82Single6TOTLemborexant6TOT-OX1-Lemborexant
31.82Single6XBM5LWE6XBM-SMO-5LWE-Gi1/β1/γ2
31.82Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
31.82Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
31.82Single7BU7BI1671077BU7-β1-BI167107
31.82Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
31.82Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
31.82Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
31.82Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
31.82Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
31.82Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
31.82Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
31.82Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
31.82Single7V3ZCP559407V3Z-CB1-CP55940
31.82Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
31.82Single7WC7Lisuride7WC7-5-HT2A-Lisuride
31.82Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
31.82Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
31.82Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
31.82Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
31.82Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
31.82Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
31.82Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
31.82Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
31.82Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
31.82Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.82Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.82Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.82Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.82Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.82Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.82Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.82Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.82Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.82Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.82Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
31.82Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
31.82Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
31.82Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
31.82Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
31.82Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
31.82Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
31.82Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
31.82Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
31.82Single8JXRLSD8JXR-D1-LSD
31.82Single8PJKST1718PJK-5-HT1A-ST171-Gi1/β1/γ1
31.82Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
31.82Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
31.82Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
31.82Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.82Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.82Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.82Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.82Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
31.82Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
31.82Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
31.82Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
31.82Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
31.82Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
31.82Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
31.82Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
31.82Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
31.82Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
31.82Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
31.82Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
31.82Consensusdopamine_offOrthosteric Ligandd2_off d3_off
31.82Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
31.82Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
31.82Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
31.82Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
31.82Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
31.82Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
31.58Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.58Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
31.25Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
31.25Single8IY6Endothelin-18IY6-ETB-Endothelin-1
31.25Consensusendothelin_onOrthosteric Ligandetb_on eta_on
31.03Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
31.03Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
31.03Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
31.03Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
31.03Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
31.03Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
31.03Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
31.03Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
31.03Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
31.03Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
31.03Consensusvasop-oxy_onOrthosteric Ligandv2_on
31.03Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
30.77Single5ZTYAM102575ZTY-CB2-AM10257
30.77Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
30.77Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
30.77Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
30.77Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
30.77Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
30.77Single7XN9L-054,5227XN9-SST2-L-054,522
30.77Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
30.77Single9CGKC5-Quino9CGK-δ-C5-Quino-Gi1/β1/γ2
30.77Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
30.77Single9JF4PD1683689JF4-BB1-PD168368
30.77Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
30.77Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
30.77Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
30.77Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
30.77Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
30.77Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
30.77Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
30.77Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
30.77Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
30.43Single2RH1S-Carazolol2RH1-β2-S-Carazolol
30.43Single2YCWS-Carazolol2YCW-β1-S-Carazolol
30.43Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
30.43Single5D6LS-Carazolol5D6L-β2-S-Carazolol
30.43Single5N2RPSB-365N2R-A2A-PSB-36-Na
30.43Single5WQCEMPA5WQC-OX2-EMPA
30.43Single6D26Fevipiprant6D26-DP2-Fevipiprant
30.43Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
30.43Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
30.43Single6TP6Filorexant6TP6-OX1-Filorexant
30.43Single7C4SS1P7C4S-S1P3-S1P
30.43Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
30.43Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
30.43Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
30.43Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
30.43Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
30.43Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
30.43Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
30.43Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.43Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.43Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
30.43Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
30.43Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
30.43Single8S4DCMF-0198S4D-Apelin-CMF-019
30.43Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
30.43Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
30.43Single9ARYSerotonin9ARY-5-HT2A-Serotonin-chim(NtGi1-Gs-CtGq)/β1/γ2
30.43Single9CIBFCH-22964139CIB-HCA2-FCH-2296413
30.43Single9EE8Adenosine9EE8-A2A-Adenosine-Gs/β1/γ2
30.43Single9GE2ML1849GE2-GPR55-ML184-chim(NtGi1-G13)/β1/γ2
30.43Single9K07DSO-5a9K07-BB3-DSO-5a-chim(NtGi2L-Gs-CtGq)/β1/γ2
30.43Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
30.43Consensusamine_offonOrthosteric Ligandamine_off amine_on
30.43Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
30.43Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
30.43Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
30.43Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
30.43Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
30.43Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
30.43Consensusdp_offOrthosteric Liganddp2_off
30.43Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
30.43Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
30.43Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
30.43Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
30.43Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
30.43Consensustrace-amine_onOrthosteric Ligandta1_on
30.00Single3OE9IT1t3OE9-CXCR4-IT1t
30.00Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
30.00Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
30.00Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
30.00Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
30.00Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
30.00Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
30.00Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
30.00Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
30.00Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
30.00Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
30.00Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
30.00Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
30.00Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
30.00Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
30.00Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
29.73Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
29.73Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
29.63Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
29.63Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
29.63Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
29.63Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
29.63Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
29.63Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
29.63Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
29.63Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
29.63Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
29.63Single8WKYPG-9348WKY-MC4-PG-934
29.63Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
29.63Single8ZBJSomatostatin-148ZBJ-SST5-Somatostatin-14-Gi1/β1/γ2
29.63Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
29.63Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
29.63Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
29.63Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
29.63Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
29.63Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
29.63Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
29.63Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
29.63Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
29.41Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
29.17Single5D5AS-Carazolol5D5A-β2-S-Carazolol
29.17Single5D5BS-Carazolol5D5B-β2-S-Carazolol
29.17Single5XR8AM8415XR8-CB1-AM841
29.17Single5XRAAM115425XRA-CB1-AM11542
29.17Single6J20Aprepitant6J20-NK1-Aprepitant
29.17Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
29.17Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
29.17Single6OS1TRV0266OS1-AT1-TRV026
29.17Single6TQ7SB-3348676TQ7-OX1-SB-334867
29.17Single7B6WCyclazosin7B6W-α1b-Cyclazosin
29.17Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
29.17Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
29.17Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
29.17Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
29.17Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
29.17Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
29.17Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
29.17Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
29.17Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
29.17Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
29.17Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
29.17Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
29.17Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
29.17Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
29.17Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
29.17Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
29.17Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
29.17Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
29.03Single7SK3CXCL127SK3-ACKR3-CXCL12
29.03Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
29.03Single9KFKRelaxin-39KFK-RXFP4-Relaxin-3-Gi2/β1/γ2
29.03Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
29.03Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
28.57Single3ODUIT1t3ODU-CXCR4-IT1t
28.57Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
28.57Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
28.57Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
28.57Single6AKXA4R6AKX-CCR5-A4R
28.57Single6B73MP11046B73-κ-MP1104
28.57Single6HLOAprepitant6HLO-NK1-Aprepitant
28.57Single6ME2Ramelteon6ME2-MT1-Ramelteon
28.57Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
28.57Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
28.57Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
28.57Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
28.57Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
28.57Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
28.57Single7SK5CXCL127SK5-ACKR3-CXCL12
28.57Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
28.57Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
28.57Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
28.57Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
28.57Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
28.57Single7XRRLemborexant7XRR-OX2-Lemborexant
28.57Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
28.57Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
28.57Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
28.57Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
28.57Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
28.57Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
28.57Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
28.57Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
28.57Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
28.57Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
28.57Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
28.57Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
28.57Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
28.57Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
28.57Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
28.57Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
28.57Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
28.57Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
28.57Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
28.57Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
28.57Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
28.57Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
28.57Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
28.57Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
28.57Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
28.57Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
28.57Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
28.57Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
28.57Single9EBHAdenosine9EBH-A3A-Adenosine-Gi1/β1/γ2
28.57Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
28.57Single9IK8SST analogue9IK8-SST1-SST analogue-Gi1/β1/γ2
28.57Single9IQRMuscarinic toxin 39IQR-α2a-Muscarinic toxin 3
28.57Single9KFIRelaxin-39KFI-RXFP3-Relaxin-3-Gi2/β1/γ2
28.57Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
28.57Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
28.57Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
28.57Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
28.57Consensusalpha2_offOrthosteric Ligandalpha2c_off
28.57Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
28.57Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
28.57Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
28.57Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
28.57Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
28.57Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
28.57Consensusorexin_offOrthosteric Ligandox2_off ox1_off
28.57Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
28.57Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
28.12Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
28.12Single8W8WAlpha-MSH8W8W-MC3-α-MSH-Ca-Gs/β1/γ2
28.00Single3D4STimolol3D4S-β2-Timolol
28.00Single6A93Risperidone6A93-5-HT2A-Risperidone
28.00Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
28.00Single6CM4Risperidone6CM4-D2-Risperidone
28.00Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
28.00Single6ZG4HTL00099366ZG4-M1-HTL0009936
28.00Single7DFPSpiperone7DFP-D2-Spiperone
28.00Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
28.00Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
28.00Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
28.00Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
28.00Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
28.00Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
28.00Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
28.00Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
28.00Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
28.00Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
28.00Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
28.00Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
28.00Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
28.00Single8XYIVUF106618XYI-CXCR3-VUF10661
28.00Single9EBIPiclidenoson9EBI-A3A-Piclidenoson-chim(NtGi1L-Gs-CtGi1)/β1/γ2
28.00Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
28.00Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
28.00Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
28.00Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
28.00Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
28.00Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
28.00Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
28.00Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
28.00Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
28.00Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
28.00Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
28.00Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
27.59Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
27.59Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
27.59Single6W25SHU91196W25-MC4-SHU9119-Ca
27.59Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
27.59Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
27.59Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
27.59Single8W8YGamma-MSH8W8Y-MC3-γ-MSH-Ca-Gs/β1/γ2
27.59Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
27.59Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
27.59Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
27.59Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
27.59Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
27.27Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
27.27Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
27.27Single4MBSMaraviroc4MBS-CCR5-Maraviroc
27.27Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
27.27Single4ZJCSB-6740424ZJC-OX1-SB-674042
27.27Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
27.27Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
27.27Single5UVIZM-2413855UVI-A2A-ZM-241385
27.27Single6KUXRS-799486KUX-α2a-RS-79948
27.27Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
27.27Single6MH8ZM-2413856MH8-A2A-ZM-241385
27.27Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
27.27Single6TPNHTL66416TPN-OX2-HTL6641
27.27Single6V9SGTPL114036V9S-OX1-GTPL11403
27.27Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
27.27Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
27.27Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
27.27Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
27.27Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
27.27Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
27.27Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
27.27Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
27.27Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
27.27Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
27.27Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
27.27Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
27.27Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
27.27Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
27.27Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
27.27Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
27.27Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.27Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
27.27Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
27.27Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
27.27Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
27.27Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
27.27Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
27.27Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
27.27Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
27.27Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
27.27Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.27Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.27Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
27.27Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
27.27Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
27.27Single9ARXSerotonin9ARX-5-HT2A-Serotonin
27.27Single9AS3LSD9AS3-5-HT2A-LSD
27.27Single9AS4LSD9AS4-5-HT2A-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
27.27Single9AS5Mescaline9AS5-5-HT2A-Mescaline
27.27Single9AS6Mescaline9AS6-5-HT2A-Mescaline-chim(NtGi1-Gs-CtGq)/β1/γ2
27.27Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
27.27Consensusalpha1_onOrthosteric Ligandalpha1a_on
27.27Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
27.27Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
27.27Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
27.27Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
27.27Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
27.27Consensushca_onOrthosteric Ligandhca2_on
27.27Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
26.92Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
26.92Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
26.92Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
26.92Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
26.92Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
26.92Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
26.92Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
26.92Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
26.92Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
26.92Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
26.92Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
26.92Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
26.92Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
26.92Single9AS02-bromo-LSD9AS0-5-HT2A-2-bromo-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
26.92Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
26.92Consensusprostanoid_offOrthosteric Ligandep_off dp_off
26.67Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
26.67Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
26.67Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
26.67Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
26.67Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
26.67Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
26.67Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
26.67Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
26.47Consensusclass-a_class-b1_cons_onOrthosteric Ligandclass-a_on class-b1_on
26.32Single3OE8IT1t3OE8-CXCR4-IT1t
26.32Single3RFMCaffeine3RFM-A2A-Caffeine
26.32Single8A2OTheophylline8A2O-A2A-Theophylline-Na
26.09Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
26.09Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
26.09Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
26.09Single4QIMANTA XV4QIM-SMO-ANTA XV
26.09Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
26.09Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
26.09Single6DRXLisuride6DRX-5-HT2B-Lisuride
26.09Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
26.09Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
26.09Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
26.09Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
26.09Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
26.09Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
26.09Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
26.09Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
26.09Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
26.09Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
26.09Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
26.09Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
26.09Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
26.09Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
26.09Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
26.09Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
26.09Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
26.09Single8JJOAlprenolol8JJO-β2-Alprenolol
26.09Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
26.09Single8K5DGSK2560738K5D-HCA2-GSK256073
26.09Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
26.09Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
26.09Single8T1WCVN4248T1W-GPR6-CVN424
26.09Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
26.09Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
26.09Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
26.09Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
26.09Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
26.09Single9IYAONO-97105319IYA-GPR55-ONO-9710531
26.09Single9IZCMK19039IZC-HCA2-MK1903-Gi1/β1/γ2
26.09Single9PLNN-(5-methylnaphthalen-1-yl)pyridin-4-amine9PLN-α2a-N-(5-methylnaphthalen-1-yl)pyridin-4-amine
26.09Single9PLON-(5-methylnaphthalen-1-yl)pyridin-4-amine9PLO-α2a-N-(5-methylnaphthalen-1-yl)pyridin-4-amine-Go/β1/γ2
26.09Single9PQD(6m)-1-methyl-6-(1,2,5,6-tetrahydropyridin-3-yl)-1h-indole9PQD-α2a-(6m)-1-methyl-6-(1,2,5,6-tetrahydropyridin-3-yl)-1h-indole
26.09Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
26.09Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
26.09Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
26.09Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
26.09Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
26.09Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
26.09Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
26.09Consensusblt_onOrthosteric Ligandblt1_on
26.09Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
26.09Consensuscck_offOrthosteric Ligandccka_off
26.09Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
26.09Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
26.09Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
26.09Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
26.09Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
26.09Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
26.09Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
26.09Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
26.09Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
26.09Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
26.09Consensushca_on_gpOrthosteric Ligandhca2_on_gp
26.09Consensusleukotriene_onOrthosteric Ligandblt_on
26.09Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
26.09Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
25.93Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
25.93Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
25.93Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.93Single7SK9CCX6627SK9-ACKR3-CCX662
25.93Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
25.93Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
25.93Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
25.93Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
25.93Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
25.93Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
25.93Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
25.93Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
25.93Consensuskisspeptin_onOrthosteric Ligandkiss1_on
25.81Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
25.81Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
25.81Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
25.81Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
25.81Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
25.81Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
25.81Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
25.81Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
25.81Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
25.81Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
25.81Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
25.81Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
25.58Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
25.00Single3OE6IT1t3OE6-CXCR4-IT1t
25.00Single3UZAGTPL92363UZA-A2A-GTPL9236
25.00Single4NTJAZD12834NTJ-P2Y12-AZD1283
25.00Single5XPRBosentan5XPR-ETB-Bosentan
25.00Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
25.00Single6LUQHaloperidol6LUQ-D2-Haloperidol
25.00Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
25.00Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
25.00Single6PS6Timolol6PS6-β2-Timolol
25.00Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
25.00Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
25.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
25.00Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
25.00Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
25.00Single7QA8Peptide7QA8-STE2-Peptide
25.00Single7QA8Peptide7QA8-STE2-Peptide
25.00Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
25.00Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
25.00Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
25.00Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
25.00Single7W41PD1762527W41-BB2-PD176252
25.00Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
25.00Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
25.00Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
25.00Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
25.00Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
25.00Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
25.00Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
25.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
25.00Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
25.00Single8U4OCXCL128U4O-CXCR4-CXCL12-Gi1/β1/γ2
25.00Single8XYKVUF106618XYK-CXCR3-VUF10661-Go/β1/γ2
25.00Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
25.00Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
25.00Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
25.00Single9ARZ2-bromo-LSD9ARZ-5-HT2A-2-bromo-LSD
25.00Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
25.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
25.00Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
25.00Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
25.00Single9F33FOB02-04A9F33-D3-FOB02-04A-Go/β1/γ2
25.00Single9F34FOB02-04A9F34-D3-FOB02-04A-Go/β1/γ2
25.00Single9HAPTolvaptan9HAP-V2-Tolvaptan
25.00Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
25.00Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
25.00Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
25.00Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
25.00Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
25.00Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
25.00Consensusbombesin_offOrthosteric Ligandbb2_off
25.00Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
25.00Consensuscrf_on_gpOrthosteric Ligandcrf2_on_gp crf1_on_gp
25.00Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
25.00Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
25.00Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
25.00Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
25.00Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
25.00Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
24.32Consensusclass-a_class-b1_cons_on_gpOrthosteric Ligandclass-a_on_gp class-b1_on_gp
24.24Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
24.24Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
24.24Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
24.24Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
24.14Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
24.14Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
24.14Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
24.14Single8IEBA1LYA8IEB-GPR156-A1LYA
24.14Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
24.14Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
24.00Single5V54Methiothepin5V54-5-HT1B-Methiothepin
24.00Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
24.00Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
24.00Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
24.00Single6E59L-7607356E59-NK1-L-760735
24.00Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
24.00Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
24.00Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
24.00Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
24.00Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
24.00Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
24.00Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
24.00Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
24.00Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
24.00Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
24.00Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
24.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
24.00Single9IK9SST analogue9IK9-SST1-SST analogue-Gi1/β1/γ2
24.00Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
24.00Consensus5ht1_offOrthosteric Ligand5ht1b_off
24.00Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
24.00Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
24.00Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
24.00Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
24.00Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
24.00Consensustachykinin_offOrthosteric Ligandnk1_off
23.81Single3PBLEticlopride3PBL-D3-Eticlopride
23.81Single6HLLCP999946HLL-NK1-CP99994
23.81Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
23.81Single6TP4ACT-4622066TP4-OX1-ACT-462206
23.81Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
23.81Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
23.81Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
23.81Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
23.81Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
23.81Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
23.81Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
23.81Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
23.81Single8K5BNiacin8K5B-HCA2-Niacin
23.81Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
23.81Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
23.81Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
23.81Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
23.81Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
23.81Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
23.81Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
23.81Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
23.81Single9IXJHistamine9IXJ-H2-Histamine-Gs/β1/γ2
23.81Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
23.81Single9LMPNE52-QQ579LMP-GPR4-NE52-QQ57
23.81Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
23.68Consensuspth_onOrthosteric Ligandpth1_on pth2_on
23.53Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
23.53Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
23.53Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
23.53Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
23.53Consensuspth1_onOrthosteric Ligand6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
23.33Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.33Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
23.33Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
23.33Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
23.33Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
23.08Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
23.08Single4XEENeurotensin4XEE-NTS1-Neurotensin
23.08Single4XESNeurotensin4XES-NTS1-Neurotensin
23.08Single5TZYMK8666; AP85TZY-FFA1-MK8666; AP8
23.08Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
23.08Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
23.08Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
23.08Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
23.08Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
23.08Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
23.08Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.08Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
23.08Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
23.08Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
23.08Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
23.08Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
23.08Single9BJKNAM9BJK-μ-Naloxone-NAM
23.08Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
23.08Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
23.08Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
23.08Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
23.08Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
22.86Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
22.86Consensuscrf1_onOrthosteric Ligand6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF1-Corticoliberin-Gs/β1/γ2
22.73Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
22.73Single5WS3EMPA5WS3-OX2-EMPA
22.73Single6AKYMaraviroc6AKY-CCR5-Maraviroc
22.73Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
22.73Single6DS0Ly2660976DS0-5-HT2B-Ly266097
22.73Single6TODEMPA6TOD-OX1-EMPA-Na
22.73Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
22.73Single7F8ULintitript7F8U-CCKA-Lintitript
22.73Single7F8YDevazepide7F8Y-CCKA-Devazepide
22.73Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
22.73Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.73Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
22.73Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
22.73Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
22.73Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
22.73Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
22.73Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
22.73Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
22.73Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
22.73Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
22.73Single8GNGIstradefylline8GNG-A2A-Istradefylline
22.73Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
22.73Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
22.73Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.73Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
22.73Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
22.73Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
22.73Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
22.73Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
22.73Single9EEAAdenosine9EEA-A2A-Adenosine-Gs/β1/γ2
22.73Single9KPESA09KPE-TAS2R16-SA0-Gi1/β1/γ2
22.73Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
22.73Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
22.73Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.73Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
22.73Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
22.73Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
22.73Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
22.73Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
22.58Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
22.58Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
22.58Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
22.58Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
22.58Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
22.58Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
22.58Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
22.58Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
22.58Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ2
22.58Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
22.58Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
22.58Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
22.58Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
22.50Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
22.50Consensuspth2_on_gpOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
22.22Single4BUONeurotensin4BUO-NTS1-Neurotensin
22.22Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
22.22Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
22.22Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
22.22Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
22.22Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
22.22Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
22.22Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
22.22Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
22.22Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
22.22Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
22.22Single8JPFNeurotensin8JPF-NTS1-Neurotensin-SBI-553
22.22Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
22.22Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
22.22Consensuschemerin_onOrthosteric Ligandcml1_on
22.22Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.22Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.22Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
21.88Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
21.88Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
21.88Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
21.88Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
21.88Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
21.88Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
21.88Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
21.88Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
21.88Consensusvpac_onOrthosteric Ligandvpac1_on vpac2_on
21.74Single2YDOAdenosine2YDO-A2A-Adenosine
21.74Single6A94Zotepine6A94-5-HT2A-Zotepine
21.74Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
21.74Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
21.74Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
21.74Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
21.74Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
21.74Single6TP3Nemorexant6TP3-OX1-Nemorexant
21.74Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
21.74Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
21.74Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
21.74Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
21.74Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
21.74Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
21.74Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
21.74Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
21.74Single7UL3Famotidine7UL3-H2-Famotidine
21.74Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
21.74Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
21.74Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
21.74Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
21.74Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
21.74Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
21.74Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
21.74Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
21.74Single8K2WAMG4878K2W-CXCR3-AMG487
21.74Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
21.74Single8RLNLUF58348RLN-A2A-LUF5834
21.74Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.74Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
21.74Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
21.74Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
21.74Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
21.74Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.74Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
21.74Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
21.74Single8ZPMAMD0708ZPM-CXCR4-AMD070
21.74Single8ZPNAMD31008ZPN-CXCR4-AMD3100
21.74Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
21.74Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
21.74Single9JFUNE52-QQ579JFU-GPR4-NE52-QQ57
21.74Single9JH3CMF-0199JH3-Apelin-CMF-019-Gi1/β1/γ2
21.74Single9K0KUTP9K0K-P2Y4-UTP-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Single9K0XATP9K0X-P2Y2-ATP-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Gi1/β1/γ2
21.74Single9K20ATP9K20-P2Y2-ATP-chim(NtGi1-Go)/β1/γ2
21.74Single9KPDSA09KPD-TAS2R16-SA0-chim(Gs-CtGt3)/β1/γ2
21.74Single9M2FNeuropeptide FF9M2F-NPFF1-Neuropeptide FF-Gi1/β1/γ2
21.74Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
21.74Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
21.74Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
21.74Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
21.74Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
21.62Consensuscrf1_on_gpOrthosteric Ligand6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF1-Corticoliberin-Gs/β1/γ2
21.62Consensusglp1_on_gpOrthosteric Ligand7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
21.62Consensuspth1_on_gpOrthosteric Ligand6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
21.43Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
21.43Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
21.43Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
21.43Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
21.43Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
21.43Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
21.43Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
21.43Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
21.43Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
21.43Single9JH6C20:0 Ceramide9JH6-CysLT2-C20:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Consensuspth_on_gpOrthosteric Ligandpth1_on_gp pth2_on_gp
21.21Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
21.21Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
21.21Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
21.21Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
21.21Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
21.21Consensuspac1_onOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
21.21Consensuspac1_on_gpOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
21.21Consensuspac_on_gpOrthosteric Ligandpac1_on_gp
21.21Consensusvpac_on_gpOrthosteric Ligandvpac1_on_gp vpac2_on_gp
21.05Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
21.05Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
21.05Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
21.05Single8PWNTheophylline8PWN-A2A-Theophylline
21.05Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
20.83Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
20.83Single4YAYZD-71554YAY-AT1-ZD-7155
20.83Single6D27CAY104716D27-DP2-CAY10471
20.83Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
20.83Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
20.83Single6GPSMK08126GPS-CCR2-MK0812
20.83Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
20.83Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
20.83Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
20.83Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
20.83Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
20.83Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
20.83Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
20.83Single7YXAONO-54306087YXA-S1P5-ONO-5430608
20.83Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
20.83Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
20.83Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
20.83Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
20.83Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
20.83Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
20.83Single8X63Mepyramine8X63-H1-Mepyramine
20.83Single8X64Desloratadine8X64-H1-Desloratadine
20.83Single8ZYYNeurotensin peptide 8-138ZYY-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
20.83Single9AS1DMT9AS1-5-HT2A-DMT
20.83Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
20.83Single9JGKBalovaptan9JGK-5-HT2B-Balovaptan
20.83Single9KFJPubChem 1383196749KFJ-RXFP3-PubChem 138319674-Gi2/β1/γ2
20.83Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
20.83Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
20.83Consensusalpha2_onOrthosteric Ligandalpha2b_on
20.83Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
20.83Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
20.83Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
20.83Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
20.83Consensushistamine_offOrthosteric Ligandh1_off
20.83Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
20.69Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
20.69Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
20.69Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
20.69Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
20.69Single8IEBA1LYA8IEB-GPR156-A1LYA
20.69Single8IEIA1LYA8IEI-GPR156-A1LYA
20.69Single8IEPA1LYA8IEP-GPR156-A1LYA
20.69Single8IEPA1LYA8IEP-GPR156-A1LYA
20.69Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
20.69Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
20.69Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
20.69Single8XWNCXCL88XWN-CXCR2-CXCL8
20.69Single8YWFRetatrutide8YWF-GLP-1-Retatrutide-chim(NtGi1-Gs)/β1/γ2
20.69Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
20.69Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
20.59Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
20.59Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
20.59Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
20.59Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
20.59Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
20.59Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
20.59Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
20.59Consensusglp_onOrthosteric Ligandglp1_on glp2_on
20.59Consensusglp_on_gpOrthosteric Ligandglp1_on_gp glp2_on_gp
20.59Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
20.00Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
20.00Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
20.00Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
20.00Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
20.00Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
20.00Single6GPXMK08126GPX-CCR2-MK0812
20.00Single6HLPNetupitant6HLP-NK1-Netupitant
20.00Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
20.00Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
20.00Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
20.00Single6TQ9SB-4081246TQ9-OX1-SB-408124
20.00Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
20.00Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
20.00Single6Z4SSR486926Z4S-NTS1-SR48692
20.00Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
20.00Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
20.00Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
20.00Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
20.00Single7SINNPS-21437SIN-CaS-NPS-2143
20.00Single7SINNPS-21437SIN-CaS-NPS-2143
20.00Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
20.00Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
20.00Single7XNACYN1548067XNA-SST2-CYN154806
20.00Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
20.00Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single8ZMFA1L108ZMF-5-HT2C-A1L10
20.00Single8ZYTNeurotensin peptide 8-138ZYT-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
20.00Single9BYOExendin-39BYO-GLP-1-Exendin-3-Gs/β1/γ2
20.00Single9CHUNoradrenaline9CHU-β2-Noradrenaline
20.00Single9DYDAsenapine9DYD-5-HT1A-Asenapine-Go/β1/γ2
20.00Single9DYFAsenapine9DYF-5-HT1A-Asenapine-Gi1/β1/γ2
20.00Single9EE9Adenosine9EE9-A2A-Adenosine-Gs/β1/γ2
20.00Single9IQVMuscarinic toxin 39IQV-Alpha1A-Muscarinic toxin 3
20.00Single9KPFSA09KPF-TAS2R16-SA0-Gi1/β1/γ2
20.00Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
20.00Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
20.00Consensusblt_offOrthosteric Ligandblt1_off
20.00Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
20.00Consensusgs_histamineOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
20.00Consensush2_onOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
20.00Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
20.00Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
20.00Consensusvip-pacap_onOrthosteric Ligandvpac_on pac_on
20.00Consensusvip-pacap_on_gpOrthosteric Ligandvpac_on_gp pac_on_gp
19.51Consensusclass-b1_onOrthosteric Ligandglucagon_on vip-pacap_on pth_on crf_on calcitonin_on
19.44Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
19.35Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
19.35Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
19.35Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
19.35Single9B5YLong-Acting PTH9B5Y-PTH1-Long-Acting PTH-chim(NtGi1-Gq)/β1/γ2
19.35Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
19.23Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
19.23Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
19.23Single4BV0Neurotensin4BV0-NTS1-Neurotensin
19.23Single4U15Tiotropium4U15-M3-Tiotropium
19.23Single5TZRMK86665TZR-FFA1-MK8666
19.23Single5V56TC1145V56-SMO-TC114
19.23Single6OL9Tiotropium6OL9-M5-Tiotropium
19.23Single7F1TMIP-1a7F1T-CCR5-MIP-1a
19.23Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
19.23Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
19.23Single7R0CAVP7R0C-V2-AVP-Arrestin2
19.23Single7T9NDPPC7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
19.23Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
19.23Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
19.23Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
19.23Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
19.23Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
19.23Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
19.23Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
19.23Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
19.23Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
19.23Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
19.23Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
19.23Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
19.23Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
19.23Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
19.23Consensusneurotensin_onOrthosteric Ligandnts1_on
19.23Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
19.23Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
19.23Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
19.05Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
19.05Single6ME5Agomelatine6ME5-MT1-Agomelatine
19.05Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
19.05Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
19.05Single7WC5Psilocin7WC5-5-HT2A-Psilocin
19.05Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
19.05Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
19.05Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.05Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
19.05Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
19.05Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
19.05Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
19.05Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
19.05Consensus5ht2_onOrthosteric Ligand5ht2b_on
19.05Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
19.05Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
18.92Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
18.92Consensusglp1_onOrthosteric Ligand7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
18.75Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
18.75Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
18.75Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
18.75Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
18.75Single9EBOGLP-1 (ACPC18)9EBO-GLP-1-GLP-1 (ACPC18)-Gs/β1/γ2
18.52Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
18.52Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
18.52Single4N4WSANT-14N4W-SMO-SANT-1
18.52Single5CXVTiotropium5CXV-M1-Tiotropium
18.52Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
18.52Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
18.52Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
18.52Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
18.52Single6YVRNTS8-136YVR-NTS1-NTS8-13
18.52Single7K15MKD0467K15-BLT1-MKD046-Na
18.52Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
18.52Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
18.52Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
18.52Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
18.52Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.52Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
18.52Single8JD3JNJ-404118138JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
18.52Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
18.52Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
18.52Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
18.52Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
18.52Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
18.52Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
18.52Single8Y6WTUG-13758Y6W-FFA2-TUG-1375-4-CMTB-Gi1/β1/γ2
18.52Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
18.52Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
18.52Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
18.52Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
18.42Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
18.42Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
18.42Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
18.18Single5L7IVismodegib5L7I-SMO-Vismodegib
18.18Single6LI0C176LI0-GPR52-C17
18.18Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
18.18Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
18.18Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
18.18Single7SRQLSD7SRQ-5-HT2B-LSD
18.18Single7XP6Strychnine7XP6-TAS2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
18.18Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.18Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
18.18Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
18.18Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
18.18Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
18.18Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
18.18Single9AS2DMT9AS2-5-HT2A-DMT-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
18.18Single9IZDCHBA9IZD-HCA1-CHBA-Gi1/β1/γ2
18.18Consensusgq_nucleotideOrthosteric Ligandgq_p2y
18.18Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
18.18Consensuspac_onOrthosteric Ligandpac1_on
18.18Consensusvpac1_onOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
17.95Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
17.95Consensusglucagon_onOrthosteric Ligandglp_on gluc_on secretin_on gip_on
17.86Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
17.86Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
17.86Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
17.86Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-SBI-553-chim(NtGi1-Go)/β1/γ2
17.86Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
17.86Single8XVJMacitentan8XVJ-ETA-Macitentan
17.86Single8XVUCXCL28XVU-CXCR2-CXCL2
17.86Single8XWFCXCL38XWF-CXCR2-CXCL3
17.86Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
17.86Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
17.78Consensusclass-b1_on_gpOrthosteric Ligandglucagon_on_gp vip-pacap_on_gp pth_on_gp crf_on_gp calcitonin_on_gp
17.65Single6FJ3PTH6FJ3-PTH1-PTH
17.65Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
17.65Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
17.65Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
17.65Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
17.65Consensussecretin_onOrthosteric Ligand7D3S-Secretin-Secretin-Gs/β1/γ2
17.65Consensusvpac1_on_gpOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
17.50Consensusglucagon_on_gpOrthosteric Ligandglp_on_gp gluc_on_gp secretin_on_gp gip_on_gp
17.39Single4S0VSuvorexant4S0V-OX2-Suvorexant
17.39Single5ZKQABT-4915ZKQ-PAF-ABT-491
17.39Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
17.39Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
17.39Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
17.39Single6ME9Ramelteon6ME9-MT2-Ramelteon
17.39Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
17.39Single6TPJSuvorexant6TPJ-OX2-Suvorexant
17.39Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
17.39Single7BR3Elagolix7BR3-GnRH1-Elagolix
17.39Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
17.39Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
17.39Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
17.39Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
17.39Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
17.39Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.39Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
17.39Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
17.39Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
17.39Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.39Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.39Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
17.39Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
17.39Single8IWESpermidine8IWE-TA9-Spermidine
17.39Single8T3VDocosa-4,7,10,13,16,19-Hexaenoic acid8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.39Single8U4PAMD31008U4P-CXCR4-AMD3100-Gi1/β1/γ2
17.39Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
17.39Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
17.39Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
17.39Single8Y0HVUF114188Y0H-CXCR3-VUF11418
17.39Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go/β1/γ2
17.39Single8YYWAlpha-ketoglutarate8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
17.39Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
17.39Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
17.39Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
17.39Single9K6LSA09K6L-TAS2R16-SA0-Gi2/β1/γ2
17.39Single9LRBHistamine9LRB-H1-Histamine-Gs/β1/γ2
17.39Consensusangiotensin_offOrthosteric Ligandat1_off
17.39Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
17.39Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
17.39Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
17.39Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
17.39Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
17.39Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
17.39Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
17.24Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
17.24Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
17.24Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
17.24Single9NS9TUG-13759NS9-FFA2-TUG-1375-Compound 187-Gi1/β1/γ2
17.14Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
17.14Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
17.14Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
17.14Single9BUCCagrilintide9BUC-CT-Cagrilintide-Gs/β1/γ2
17.14Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
17.14Consensussecretin_on_gpOrthosteric Ligand7D3S-Secretin-Secretin-Gs/β1/γ2
16.67Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
16.67Single3RZECidoxepin3RZE-H1-Cidoxepin
16.67Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
16.67Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
16.67Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
16.67Single6TPKRetosiban6TPK-OT-Retosiban
16.67Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
16.67Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
16.67Single6ZINSR486926ZIN-NTS1-SR48692
16.67Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
16.67Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
16.67Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
16.67Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
16.67Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
16.67Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
16.67Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
16.67Single8IEIA1LYA8IEI-GPR156-A1LYA
16.67Single8KIGSHU91198KIG-MC3-SHU9119-Ca
16.67Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
16.67Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
16.67Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
16.67Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
16.67Consensusgrh_offOrthosteric Ligandgnrh1_off
16.67Consensusopsins_offOrthosteric Ligandrhodopsin_off
16.67Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
16.67Consensussensory_offOrthosteric Ligandopsins_off
16.67Consensussomatostatin_offOrthosteric Ligandsst2_off
16.67Consensusvasop-oxy_offOrthosteric Ligandot_off
16.22Single7RBTTirzepatide7RBT-GIP-Tirzepatide-LSN3556672-chim(NtGi1-Gs)/β1/γ2
16.22Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
16.13Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
16.00Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
16.00Single4DAJTiotropium4DAJ-M3-Tiotropium
16.00Single4MQSIperoxo4MQS-M2-Iperoxo
16.00Single4U14Tiotropium4U14-M3-Tiotropium
16.00Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
16.00Single5DSGTiotropium5DSG-M4-Tiotropium
16.00Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
16.00Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
16.00Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
16.00Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
16.00Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.00Single7F83PF-051904577F83-Ghrelin-PF-05190457
16.00Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
16.00Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
16.00Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
16.00Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
16.00Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
16.00Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
16.00Single8YN8Proxyfan8YN8-H3-Proxyfan-Go/β1/γ2
16.00Single9JEAAtropine9JEA-M1-Atropine
16.00Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
16.00Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
15.79Single5MZPCaffeine5MZP-A2A-Caffeine-Na
15.79Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
15.79Single8GEJConstrained Epinephrine8GEJ-β2-Constrained Epinephrine-Gs/β1/γ2
15.62Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
15.62Consensusclass-b1_class-b2_cons_onOrthosteric Ligandclass-b1_on class-b2_on
15.62Consensusclass-b1_class-b2_cons_on_gpOrthosteric Ligandclass-b1_on_gp class-b2_on_gp
15.62Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
15.62Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
15.38Single4JKVTaladegib4JKV-SMO-Taladegib
15.38Single5T1ABMS-6815T1A-CCR2-BMS-681-PubChem 12093170
15.38Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
15.38Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
15.38Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
15.38Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
15.38Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
15.38Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
15.38Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
15.38Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
15.38Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
15.38Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.38Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.38Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
15.38Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
15.38Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
15.38Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
15.38Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
15.38Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.38Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
15.38Consensusep_offOrthosteric Ligandep4_off
15.38Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
15.38Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.38Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.15Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
15.15Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
15.15Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
15.00Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
15.00Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
15.00Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
15.00Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
14.81Single5V57TC1145V57-SMO-TC114
14.81Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
14.81Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
14.81Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
14.81Single8EA0Iperoxo8EA0-M3-Iperoxo
14.81Single8JD5JNJ-40411813; ADX881788JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
14.81Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
14.81Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
14.81Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
14.81Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
14.71Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
14.71Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
14.71Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
14.63Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
14.29Single5X33BIIL2605X33-BLT1-BIIL260
14.29Single6OY9All-trans-Retinal6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
14.29Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
14.29Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
14.29Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
14.29Single8IWM2-Phenylethylamine8IWM-TA9-2-Phenylethylamine
14.29Single8XQJJN2418XQJ-Apelin-JN241
14.29Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
14.29Single8XWACXCL18XWA-CXCR2-CXCL1
14.29Single8XWMCXCL68XWM-CXCR2-CXCL6
14.29Single8XWSCXCL58XWS-CXCR2-CXCL5
14.29Single9BLWCagrilintide backbone (non-acylated)9BLW-CT (AMY1)-Cagrilintide backbone (non-acylated)-Gs/β1/γ2; RAMP1
14.29Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
14.29Single9CM3TUG-13759CM3-FFA2-TUG-1375-Compound 187-chim(NtGi1L-Gs-CtGq)/β1/γ2
14.29Consensuscrf2_on_gpOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
14.29Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
14.29Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
14.29Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
14.29Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
14.29Consensusp2y_offOrthosteric Ligandp2y1_off
13.89Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
13.89Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
13.89Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
13.89Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
13.79Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
13.79Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
13.79Single9JH5C16:0 Ceramide9JH5-CysLT2-C16:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
13.79Single9M1HProstaglandin E29M1H-EP1-Prostaglandin E2-chim(NtGi1-Gs-CtGq)/β1/γ2
13.79Consensusfp-alpha_onOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
13.79Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
13.64Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
13.64Single4XNWMRS25004XNW-P2Y1-MRS2500
13.64Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
13.64Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
13.64Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
13.64Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
13.64Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
13.64Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
13.64Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
13.64Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/β1/γ2
13.64Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.64Single8IW72-Phenylethylamine8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
13.64Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
13.64Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
13.64Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
13.64Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
13.64Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
13.64Single9JHJC18:0 Ceramide9JHJ-FPR2-ALX-C18:0 Ceramide-Gi1/β1/γ2
13.64Single9LRCHistamine9LRC-H4-Histamine
13.64Single9LREHistamine9LRE-H4-Histamine-Gi1/β1/γ2
13.64Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
13.64Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
13.64Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
13.51Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
13.51Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
13.51Consensusctlike_on_gpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
13.51Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
13.51Consensusvpac2_on_gpOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
13.33Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
13.33Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
13.33Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
13.33Single8XQJJN2418XQJ-Apelin-JN241
13.33Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
13.33Single9CM7TUG-13759CM7-FFA2-TUG-1375-AZ-1729-Gi1/β1/γ2
13.16Consensusgip_onOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
13.16Consensusgip_on_gpOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
13.04Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
13.04Single4O9RCyclopamine4O9R-SMO-Cyclopamine
13.04Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
13.04Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
13.04Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
13.04Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
13.04Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.04Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
13.04Single7UL2SR486927UL2-NTS1-SR48692-Na
13.04Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
13.04Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
13.04Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
13.04Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
13.04Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
13.04Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.04Single8YN2Histamine8YN2-H1-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.04Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
13.04Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
13.04Single8YN7Immethridine8YN7-H3-Immethridine-Go/β1/γ2
13.04Single8ZYUNeurotensin peptide 8-138ZYU-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
13.04Single9AS7Psilocin9AS7-5-HT2A-Psilocin
13.04Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg4_on
13.04Consensusadgrg_on_gpOrthosteric Ligandadgrg2_on_gp adgrg4_on_gp
13.04Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
13.04Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
13.04Consensusneurotensin_offOrthosteric Ligandnts1_off
13.04Consensusnts1_offOrthosteric Ligand7UL2-NTS1-SR48692-Na
12.90Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
12.90Single9BUECagrilintide9BUE-CT-Cagrilintide-Gs/β1/γ2
12.90Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
12.90Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
12.82Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
12.82Single9AUCCalcitonin gene-related peptide-19AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
12.50Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
12.50Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
12.50Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
12.50Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
12.50Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
12.50Single4QINSAG1.54QIN-SMO-SAG1.5
12.50Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
12.50Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
12.50Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
12.50Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
12.50Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
12.50Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
12.50Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
12.50Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
12.50Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
12.50Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
12.50Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ2
12.50Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
12.50Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
12.50Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
12.50Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
12.50Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
12.50Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
12.50Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
12.20Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
12.20Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
12.00Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
12.00Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
12.00Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
12.00Single7T94Acetylcholine7T94-M2-Acetylcholine-LY2119620-chim(NtGi1-Go)/β1/γ2
12.00Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
12.00Single7UTZDPPC7UTZ-TSH-TR1402-DPPC-Gs/β1/γ2
12.00Single7VODCariprazine7VOD-5-HT2A-Cariprazine
12.00Single7VV6C48/807VV6-MRGPRX2-C48/80
12.00Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
12.00Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
12.00Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
12.00Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.00Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ2
12.00Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
12.00Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
12.00Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
12.00Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
12.00Single8YRGFospropofol8YRG-MRGPRX4-Fospropofol-chim(NtGi1-Gs-CtGq)/β1/γ2
12.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
12.00Single9BA0A1AKN9BA0-CB1-A1AKN
12.00Single9IXXLTD49IXX-CysLT2-LTD4-chim(NtGi1-Gs-CtGq)/β1/γ2
12.00Single9LRDHistamine9LRD-H1-Histamine-Gi1/β1/γ2
12.00Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
11.90Consensusgluc_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
11.76Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
11.76Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
11.76Single9BLCCagrilintide backbone (non-acylated)9BLC-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
11.76Single9BUDCagrilintide9BUD-CT-Cagrilintide-Gs/β1/γ2
11.63Consensusgluc_on_gpOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
11.54Single5T04Neurotensin5T04-NTS1-Neurotensin
11.54Single5TGZAM65385TGZ-CB1-AM6538
11.54Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/β1/γ2
11.54Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
11.54Single8TH3AT118-H Nanobody8TH3-AT1-AT118-H Nanobody
11.54Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
11.54Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
11.54Single9IMATalquetamab9IMA-GPRC5D-Talquetamab
11.54Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
11.54Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
11.54Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
11.43Consensuscalcitonin_onOrthosteric Ligandctlike_on
11.11Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
11.11Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
11.11Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
11.11Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
11.11Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
11.11Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
11.11Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
11.11Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
11.11Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
11.11Single9B9ZA1AKO9B9Z-CB1-A1AKO
11.11Single9BLBCagrilintide backbone (non-acylated)9BLB-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
11.11Single9BP3Cagrilintide9BP3-CT (AMY1)-Cagrilintide-Gs/β1/γ2; RAMP1
11.11Single9HC04YI9HC0-mGlu5-4YI
11.11Consensuscalcitonin_on_gpOrthosteric Ligandctlike_on_gp
11.11Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
11.11Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
11.11Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
10.87Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
10.81Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
10.81Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
10.81Consensusglp2_on_gpOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
10.71Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
10.71Single7P2L4YI7P2L-mGlu5-4YI
10.71Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
10.71Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
10.71Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
10.71Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
10.71Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
10.71Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Gi1/β1/γ1
10.71Single8ZW0PGD28ZW0-DP1-PGD2-Gs/β1/γ2
10.71Single9AS9RS130-1809AS9-5-HT2A-RS130-180
10.71Single9ASARS130-1809ASA-5-HT2A-RS130-180-chim(NtGi1-Gs-CtGq)/β1/γ2
10.71Single9CLWTUG-13759CLW-FFA2-TUG-1375-4-CMTB-chim(NtGi1L-Gs-CtGq)/β1/γ2
10.71Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
10.53Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
10.53Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
10.34Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
10.34Single8XJNCloprosetnol8XJN-TXA2-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
10.34Single9AU0BW245C9AU0-DP1-BW245C-Gs/β1/γ2
10.34Single9GGGI-BOP9GGG-TXA2-I-BOP-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.00Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
10.00Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
10.00Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
10.00Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
10.00Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Single8XJOU466198XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Single9C0KExendin-49C0K-GLP-1-Exendin-4-Gs/β1/γ2
10.00Single9GG5U466199GG5-TXA2-U46619-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.00Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
10.00Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
10.00Consensustp_onOrthosteric Ligand8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Consensustp_on_gpOrthosteric Ligand8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
9.68Single6KNMJN241-96KNM-Apelin-JN241-9
9.52Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
9.52Single7V68LY21196207V68-M4-Iperoxo-LY2119620-Gi1/β1/γ2
9.52Single7WC4Serotonin7WC4-5-HT2A-Serotonin
9.52Single7XKDBeta-Hydroxyandrosterone7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
9.52Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
9.38Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
9.38Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
9.09Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
9.09Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
9.09Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
9.09Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
9.09Single8WC5Tetramethylammonium Ion8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
9.09Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
9.09Consensussensory_onOrthosteric Ligandopsins_on
8.70Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
8.70Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
8.70Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
8.70Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
8.70Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
8.70Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
8.70Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
8.70Consensusgi_sensoryOrthosteric Ligandgi_opsins
8.70Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
8.70Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
8.70Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
8.70Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
8.70Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
8.57Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
8.33Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
8.33Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
8.33Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
8.33Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
8.33Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
8.33Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
8.33Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
8.33Single7V68Iperoxo7V68-M4-Iperoxo-LY2119620-Gi1/β1/γ2
8.33Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab
8.33Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
8.33Single9B9Y7DY9B9Y-CB1-7DY
8.33Single9E7RGB889E7R-PAR2-GB88-chim(NtGi1L-Gs-CtGq)/β1/γ2
8.33Single9EPRRetinal9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
8.11Single9BUBCagrilintide9BUB-CT-Cagrilintide-Gs/β1/γ2
8.00Single4BWBNeurotensin4BWB-NTS1-Neurotensin
8.00Single5U09Taranabant5U09-CB1-Taranabant
8.00Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
8.00Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
8.00Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
8.00Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
8.00Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
8.00Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
8.00Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
8.00Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
7.69Single9BQ3Cagrilintide9BQ3-CT (AMY2)-Cagrilintide-Gs/β1/γ2; RAMP2
7.69Single9BTWCagrilintide9BTW-CT (AMY3)-Cagrilintide-Gs/β1/γ2; RAMP3
7.69Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
7.41Single6IIVDaltroban6IIV-TXA2-Daltroban
7.41Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
7.14Single5CGCHTL142425CGC-mGlu5-HTL14242
7.14Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
7.14Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
7.14Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
7.14Single8ZVZBW245C8ZVZ-DP1-BW245C-Gs/β1/γ2
7.14Consensusadgrg2_onOrthosteric Ligand7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
7.14Consensusadgrg2_on_gpOrthosteric Ligand7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
6.90Single8GDBPGE28GDB-EP4-PGE2-Gs/β1/γ2
6.90Single8YNTSNAP-948478YNT-MCH1-SNAP-94847
6.67Single6IIURamatroban6IIU-TXA2-Ramatroban
6.67Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
6.45Single5CGDHTL142425CGD-mGlu5-HTL14242
6.45Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
6.25Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
6.06Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
5.26Consensusclass-b2_onOrthosteric Ligandadgrg_on adgrf_on adgrl_on adgre_on adgrd_on
5.26Consensusclass-b2_on_gpOrthosteric Ligandadgrg_on_gp adgrf_on_gp adgrl_on_gp adgre_on_gp adgrd_on_gp
5.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
5.00Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
4.76Single4A4MAll-trans-Retinal4A4M-Rhodopsin-All-trans-Retinal-Gt(CT)
4.76Single5EN0All-trans-Retinal5EN0-Rhodopsin-All-trans-Retinal-Gt(CT)
4.76Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/β1/γ2
4.55Single3PXOAll-trans-Retinal3PXO-Rhodopsin-All-trans-Retinal
4.55Single5DYSAll-trans-Retinal5DYS-Rhodopsin-All-trans-Retinal
4.35Single2HPYAll-trans-Retinal2HPY-Rhodopsin-All-trans-Retinal
4.35Single6XBM5LWE6XBM-SMO-5LWE-Gi1/β1/γ2
4.35Single7Y14Beta-Alanine7Y14-MRGPRD-β-Alanine
4.35Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Gi1/β1/γ2
4.35Single8Y02Retinal8Y02-OPN1SW-Retinal-Gi1/β1/γ2
4.17Single3PQRAll-trans-Retinal3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
4.17Single7Y12Beta-Alanine7Y12-MRGPRD-β-Alanine-Gi1/β1/γ2
4.17Single8J6QCompound 9n8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
4.17Single8JPSCCL78JPS-ACKR1-CCL7
4.17Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
4.00Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
4.00Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
4.00Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/β1/γ2
4.00Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
3.85Single4XNVBPTU4XNV-P2Y1-BPTU
3.85Single7VVOPTH7VVO-PTH1-PTH-Gs/β1/γ2
3.85Single7WV9ZCZ0117WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
3.85Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
3.85Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
3.70Single6FFIMMPEP6FFI-mGlu5-MMPEP
3.70Single8IYXYL-3658IYX-GPR34-YL-365
3.70Single8JD6VU03647708JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
3.57Single6FFHFenobam6FFH-mGlu5-Fenobam
3.57Single9IVGGLP-1 (Truncated)9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
3.45Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
3.45Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
3.33Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
3.33Single8JD5JNJ-40411813; ADX881788JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
3.33Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB

Consensus Members
Id Members
8F7S 8F7S-δ-Deltorphin-Gi1/β1/γ2
Net Summary
Imin 2.44
Number of Linked Nodes 831
Number of Links 1030
Number of Hubs 164
Number of Links mediated by Hubs 623
Number of Communities 24
Number of Nodes involved in Communities 258
Number of Links involved in Communities 381
Path Summary
Number Of Nodes in MetaPath 89
Number Of Links MetaPath 88
Number of Shortest Paths 1992181
Length Of Smallest Path 3
Average Path Length 32.9904
Length of Longest Path 67
Minimum Path Strength 1.295
Average Path Strength 5.48854
Maximum Path Strength 21.12
Minimum Path Correlation 0.7
Average Path Correlation 0.98568
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.12766
Average % Of Corr. Nodes 40.8419
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 53.7066
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following differences:
Id1st Network2nd Network
dop_off_on_gpdop_on_gpdop_off
This network is also present in following consensuses:
IdComponents
opioid_on_gpmop_on_gp
nop_on_gp
dop_on_gp
kop_on_gp



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