Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
11x50 5.95158409
21x60 3.14216506
32x42 4.11359608
4E1x50 7.25952507
5E1x52 6.07623405
63x28 6.81286416
73x37 4.98045406
83x41 5.49712406
93x49 4.97622629
103x50 4.81286529
11I2x53 5.30686627
12I2x57 4.33846426
134x50 5.61583409
14E2 15.49891413
155x47 11.131407
165x58 3.68064509
176x31 3.27701405
186x41 4.17797408
196x44 6.86291509
206x48 8.38138518
216x51 8.03698517
226x52 10.7707517
23E3 5.27585644
247x39 4.66042406
257x42 6.60899617
267x53 6.24745539
278x50 5.79158408
288x54 4.75592407
29Lig 10.80821410
30I3 1.21875600
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
17x39 7x42 11.13829.23071YesYes067
22x56 7x42 56.33753.83375NoYes177
32x53 2x56 1005.89696NoNo087
42x53 7x46 93.35175.36295NoNo089
52x50 7x46 83.85289.04295NoNo099
61x50 2x50 19.36899.18446YesNo099
72x50 7x49 65.62014.31545NoNo099
87x49 7x53 44.03826.73607NoYes399
97x53 8x50 35.39087.04679YesYes098
108x50 8x54 13.01664.88938YesYes087
118x50 I1x50 13.4155.34964YesNo088
121x60 I1x50 12.20836.10446YesNo068
137x42 Lig 55.46784.56857YesYes170
143x33 Lig 38.15268.75982NoYes160
153x33 4x57 37.45135.23589NoNo067
163x34 4x57 31.08763.8192NoNo057
173x34 4x50 29.5944.64571NoYes059
182x45 4x50 33.20286.51018NoYes099
192x45 4x46 31.92786.43527NoNo097
202x42 4x46 31.28345.0975YesNo087
212x42 3x49 20.05423.57545YesYes089
222x42 4x42 10.30033.54259YesNo087
237x38 7x42 10.97428.60973NoYes167
246x51 7x38 10.92879.45571YesNo176
256x48 6x51 30.68015.73598YesYes187
266x44 6x48 68.732510.2726YesYes098
273x43 6x44 54.8696.13982NoYes089
286x51 Lig 28.193810.4362YesYes170
293x36 Lig 21.10844.1133NoYes160
303x36 6x48 20.6128.51205NoYes168
316x52 Lig 27.43798.97357YesYes170
326x48 6x52 21.6985.3325YesYes187
333x28 Lig 13.83396.38509YesYes160
34E2 Lig 23.20074.00339YesYes130
353x40 6x44 12.53166.24937NoYes089
363x40 5x50 10.8086.28705NoNo089
373x43 6x41 51.03483.61964NoYes088
383x49 I2x53 14.187.04062YesYes297
395x58 6x41 41.3475.34768YesYes098
405x58 5x61 20.26145.45955YesNo099
413x51 5x61 18.25553.09NoNo089
426x40 7x49 20.12486.98384NoNo389
436x40 7x52 19.43725.39NoNo088
446x51 7x34 11.84855.85786YesNo074
456x54 7x34 17.42453.44973NoNo044
466x55 Lig 12.78435.72964NoYes160
475x58 I3 14.0981.80813YesYes090
482x56 3x32 44.97626.19196NoNo177
493x32 Lig 45.40219.1031NoYes170
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
2x563x326.191961NoNo7721
2x567x423.833751NoYes7721
2x577x424.894020NoYes7721
2x593x287.779020NoYes4621
2x603x284.961790NoYes6621
E1x49E24.443481NoYes3321
3x28E1x508.125541YesYes6712
3x22E27.140710NoYes4321
3x264x645.034461NoNo6522
3x26E26.830541NoYes6321
3x28Lig6.385091YesYes6010
3x29E2x524.747680NoNo6421
3x327x428.517141NoYes7711
3x32Lig19.10311NoYes7010
3x334x575.235891NoNo6712
3x33Lig8.759821NoYes6010
3x366x488.512051NoYes6812
3x36Lig4.11331NoYes6010
4x63E26.62750NoYes5321
4x64E211.26741NoYes5321
E2E269.71181YesYes3311
E2E2x527.650621YesNo3411
5x39E29.745451NoYes7321
5x36E25.553131NoYes5321
E2E2x518.826791YesNo3512
E2x52Lig9.002861NoYes4010
E2Lig4.003391YesYes3010
5x395x4312.64951NoNo7621
5x43Lig4.578931NoYes6010
5x476x5227.35650YesYes7721
6x486x515.735981YesYes8721
6x486x525.33251YesYes8721
6x516x528.69921YesYes7711
6x517x345.857861YesNo7412
6x517x389.455711YesNo7611
6x51Lig10.43621YesYes7010
6x52Lig8.973571YesYes7010
6x557x343.925711NoNo6412
6x55Lig5.729641NoYes6010
7x387x428.609731NoYes6711
7x38Lig14.4711NoYes6010
7x397x429.230710YesYes6721
7x42Lig4.568571YesYes7010
5x406x554.348390NoNo6621
5x446x523.491610NoYes6721
4x61E23.037951NoYes6321
E2NT2.433751YesNo3012

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
91.67Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
84.62Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
84.62Single6PS3(S)-Carvedilol6PS3-β2-(S)-Carvedilol
84.62Single7BVQ(S)-Carazolol7BVQ-β1-(S)-Carazolol
84.62Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2
84.62Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
84.62Consensusbeta2_onOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
84.62Consensusgi_adrenergicOrthosteric Ligand7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
84.62Consensusgs_adrenergicOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJI-β3-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
83.33Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
83.33Single6PS4ICI 118-5516PS4-β2-ICI 118-551
83.33Single8GEGEpinephrine8GEG-β2-Epinephrine-Gs/&β;1/&γ;2
83.33Single8GGQEpinephrine8GGQ-β2-Epinephrine
83.33Single8UNZEpinephrine8UNZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
80.00Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
78.57Single2YDVNECA2YDV-A2A-NECA
78.57Single4UHRCGS216804UHR-A2A-CGS21680
78.57Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
78.57Single5G53NECA5G53-A2A-NECA-Gs
78.57Single6H7JIsoprenaline6H7J-β1-Isoprenaline
78.57Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2
78.57Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/&β;1/&γ;2
78.57Consensusdopamine_offOrthosteric Ligandd3_off d2_off d4_off
78.57Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2
76.92Single2Y04Salbutamol2Y04-β1-Salbutamol
76.92Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
76.92Single3NY8ICI 118-5513NY8-β2-ICI 118-551
76.92Single4GBR(S)-Carazolol4GBR-β2-(S)-Carazolol
76.92Single5JQH(S)-Carazolol5JQH-β2-(S)-Carazolol
76.92Single6H7MSalbutamol6H7M-β1-Salbutamol
76.92Single6PRZ(S)-Alprenolol6PRZ-β2-(S)-Alprenolol
76.92Single6PS0(S)-Carazolol6PS0-β2-(S)-Carazolol
76.92Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
76.92Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
76.92Single7CRHSKF839597CRH-D1-SKF83959-Gs/&β;1/&γ;2
76.92Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
76.92Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
76.92Single8GE3Epinephrine8GE3-β2-Epinephrine-Gs/&β;1/&γ;2
76.92Single8GEEEpinephrine8GEE-β2-Epinephrine-Gs/&β;1/&γ;2
76.92Single8GEHEpinephrine8GEH-β2-Epinephrine-Gs/&β;1/&γ;2
76.92Single8GFWEpinephrine8GFW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
76.92Single8GFXEpinephrine8GFX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
76.92Single8GFYEpinephrine8GFY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
76.92Single8GFZEpinephrine8GFZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
76.92Single8GG0Epinephrine8GG0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
76.92Single8GG1Epinephrine8GG1-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
76.92Single8GG2Epinephrine8GG2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
76.92Single8GG6Epinephrine8GG6-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
76.92Single8GGJEpinephrine8GGJ-β2-Epinephrine
76.92Single8GGNEpinephrine8GGN-β2-Epinephrine
76.92Single8GGOEpinephrine8GGO-β2-Epinephrine
76.92Single8GGUEpinephrine8GGU-β2-Epinephrine
76.92Single8UNNEpinephrine8UNN-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
76.92Single8UNPEpinephrine8UNP-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
76.92Consensusadrenergic_onOrthosteric Ligandbeta_on alpha_on
76.92Consensusdopamine_onOrthosteric Ligandd3_on d2_on d5_on d1_on
75.00Single6KUXRS-799486KUX-α2a-RS-79948
75.00Single6OBA(S)-Alprenolol6OBA-β2-(S)-Alprenolol-GTPL11074
75.00Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
75.00Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2
75.00Single8GECEpinephrine8GEC-β2-Epinephrine-Gs/&β;1/&γ;2
75.00Single8GEFEpinephrine8GEF-β2-Epinephrine-Gs/&β;1/&γ;2
75.00Single8GG9Epinephrine8GG9-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
75.00Single8GGAEpinephrine8GGA-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
75.00Single8GGVEpinephrine8GGV-β2-Epinephrine
75.00Single8GGXEpinephrine8GGX-β2-Epinephrine
75.00Single8GH0Epinephrine8GH0-β2-Epinephrine
75.00Single8UNWEpinephrine8UNW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
75.00Single8UO0Epinephrine8UO0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
75.00Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
75.00Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
75.00Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
75.00Consensusalpha2_offOrthosteric Ligandalpha2a_off alpha2c_off
75.00Consensusalpha2a_offOrthosteric Ligand6KUX-α2a-RS-79948
75.00Consensusbeta2_off_alloOrthosteric Ligand6OBA-β2-(S)-Alprenolol-GTPL11074
75.00Consensusgi_nucleotideOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
73.33Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
73.33Single4AMIBucindolol4AMI-β1-Bucindolol
73.33Single4LDEBI1671074LDE-β2-BI167107
73.33Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
73.33Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
73.33Single8JJ8Formoterol8JJ8-β2-Formoterol
73.33Consensusgo_5htOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
73.33Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
71.43Single2RH1(S)-Carazolol2RH1-β2-(S)-Carazolol
71.43Single2Y03Isoprenaline2Y03-β1-Isoprenaline
71.43Single2YCW(S)-Carazolol2YCW-β1-(S)-Carazolol
71.43Single5D6L(S)-Carazolol5D6L-β2-(S)-Carazolol
71.43Single5TVNLSD5TVN-5-HT2B-LSD
71.43Single5X7D(S)-Carazolol5X7D-β2-(S)-Carazolol-PubChem 129318963
71.43Single6E67BI1671076E67-β2-BI167107-Gs (fused)
71.43Single7WC6LSD7WC6-5-HT2A-LSD
71.43Single7XKAEpinephrine7XKA-β2-Epinephrine
71.43Single8UNYEpinephrine8UNY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
71.43Consensusamine_offOrthosteric Ligandadrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
71.43Consensusbeta2_offOrthosteric Ligand6PS2-β2-(S)-Alprenolol 6PS3-β2-(S)-Carvedilol 6PS5-β2-(S)-Propranolol 6PS6-β2-Timolol 2RH1-β2-(S)-Carazolol 6PS4-β2-ICI 118-551 3NY9-β2-PubChem 913103
71.43Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
71.43Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
71.43Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
71.43Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRR-D1-Rotigotine-Gs/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
71.43Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
69.23Single6PS5(S)-Propranolol6PS5-β2-(S)-Propranolol
69.23Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
69.23Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
69.23Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
69.23Single7F0TDopamine7F0T-D1-Dopamine-Gs/&β;1/&γ;2
69.23Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
69.23Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
69.23Single8GE1Epinephrine8GE1-β2-Epinephrine-Gs/&β;1/&γ;2
69.23Single8GE4Epinephrine8GE4-β2-Epinephrine-Gs/&β;1/&γ;2
69.23Single8GE6Epinephrine8GE6-β2-Epinephrine-Gs/&β;1/&γ;2
69.23Single8GE7Epinephrine8GE7-β2-Epinephrine-Gs/&β;1/&γ;2
69.23Single8GE8Epinephrine8GE8-β2-Epinephrine-Gs/&β;1/&γ;2
69.23Single8GE9Epinephrine8GE9-β2-Epinephrine-Gs/&β;1/&γ;2
69.23Single8GFVEpinephrine8GFV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
69.23Single8GG3Epinephrine8GG3-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
69.23Single8GG4Epinephrine8GG4-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
69.23Single8GG5Epinephrine8GG5-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
69.23Single8GGIEpinephrine8GGI-β2-Epinephrine
69.23Single8GGKEpinephrine8GGK-β2-Epinephrine
69.23Single8GGMEpinephrine8GGM-β2-Epinephrine
69.23Single8GGPEpinephrine8GGP-β2-Epinephrine
69.23Single8GGTEpinephrine8GGT-β2-Epinephrine
69.23Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
69.23Single8UNQEpinephrine8UNQ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
69.23Single8UNREpinephrine8UNR-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
69.23Single8UNSEpinephrine8UNS-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
69.23Single8UO2Epinephrine8UO2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
69.23Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/&β;1/&γ;2
69.23Consensus5ht5_onOrthosteric Ligand5ht5a_on
69.23Consensus5ht5a_onOrthosteric Ligand7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
69.23Consensusd1_on_alloOrthosteric Ligand7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
69.23Consensusd3_onOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
69.23Consensusgs_tarOrthosteric Ligand8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
68.75Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
68.75Single6H7LDobutamine6H7L-β1-Dobutamine
68.75Single6IBLArformoterol6IBL-β1-Arformoterol
68.75Single7XJISolabegron7XJI-β3-Solabegron-Gs/&β;1/&γ;2
68.75Consensusbeta1_off_alloOrthosteric Ligand4BVN-β1-Cyanopindolol-Na
66.67Single3P0GBI1671073P0G-β2-BI167107
66.67Single3PBLEticlopride3PBL-D3-Eticlopride
66.67Single3SN6BI1671073SN6-β2-BI167107-Gs/&β;1/&γ;2
66.67Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
66.67Single5D5A(S)-Carazolol5D5A-β2-(S)-Carazolol
66.67Single5D5B(S)-Carazolol5D5B-β2-(S)-Carazolol
66.67Single6J21Aprepitant6J21-NK1-Aprepitant
66.67Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
66.67Single6NI3BI1671076NI3-β2-BI167107-Gs/&β;1/&γ;2
66.67Single6WGTLSD6WGT-5-HT2A-LSD
66.67Single7CKYPW04647CKY-D1-PW0464-Gs/&β;1/&γ;2
66.67Single7JVPSKF839597JVP-D1-SKF83959-Gs/&β;1/&γ;2
66.67Single7W6PW967W6P-α2a-W96-Go/&β;1/&γ;2
66.67Single7W7EW587W7E-α2a-W58-Go/&β;1/&γ;2
66.67Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/&β;1/&γ;2
66.67Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2
66.67Single8GEIEpinephrine8GEI-β2-Epinephrine-Gs/&β;1/&γ;2
66.67Single8GGSEpinephrine8GGS-β2-Epinephrine
66.67Single8GGYEpinephrine8GGY-β2-Epinephrine
66.67Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/&β;1/&γ;2
66.67Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
66.67Single8UNVEpinephrine8UNV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
66.67Single8UNXEpinephrine8UNX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
66.67Consensus5ht_offOrthosteric Ligand5ht2_off 5ht5_off 5ht1_off
66.67Consensusa2_onOrthosteric Liganda2a_on a2b_on
66.67Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCZ-β1-Iodocyanopindolol
66.67Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
66.67Consensusgi_amineOrthosteric Ligandgi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
66.67Consensusgi_dopamineOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
64.71Single3NY9PubChem 9131033NY9-β2-PubChem 913103
64.71Single4UG2CGS216804UG2-A2A-CGS21680
64.29Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
64.29Single2Y01Dobutamine2Y01-β1-Dobutamine
64.29Single2Y02Carmoterol2Y02-β1-Carmoterol
64.29Single3NYA(S)-Alprenolol3NYA-β2-(S)-Alprenolol
64.29Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
64.29Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
64.29Single4QKXPubChem 762106284QKX-β2-PubChem 76210628
64.29Single6PS1Timolol6PS1-β2-Timolol
64.29Single6PS2(S)-Alprenolol6PS2-β2-(S)-Alprenolol
64.29Single7BU7BI1671077BU7-β1-BI167107
64.29Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
64.29Single7LJCPubChem 867641037LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
64.29Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2
64.29Single7WC7Lisuride7WC7-5-HT2A-Lisuride
64.29Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
64.29Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
64.29Single8GEBEpinephrine8GEB-β2-Epinephrine-Gs/&β;1/&γ;2
64.29Single8GGBEpinephrine8GGB-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
64.29Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2
64.29Single8JJOAlprenolol8JJO-β2-Alprenolol
64.29Single8JLZST19368JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
64.29Single8UNMEpinephrine8UNM-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
64.29Single8UO4Epinephrine8UO4-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
64.29Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
64.29Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
64.29Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
64.29Consensusalpha2_onOrthosteric Ligandalpha2a_on alpha2b_on
64.29Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
64.29Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
64.29Consensusamine_onOrthosteric Ligandadrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on
64.29Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
64.29Consensusgi_5htOrthosteric Ligand7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
64.29Consensustar_onOrthosteric Ligandta1_on
62.50Single3D4STimolol Maleate3D4S-β2-Timolol Maleate
62.50Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
62.50Single6H7N(S)-Xamoterol6H7N-β1-(S)-Xamoterol
62.50Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
62.50Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/&β;1/&γ;2
62.50Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
62.50Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
62.50Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
62.50Single8JJLOlodaterol8JJL-β2-Olodaterol
62.50Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
62.50Consensusbeta1_onOrthosteric Ligand7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
62.50Consensusopioid_offOrthosteric Ligandkop_off mop_off nop_off dop_off
61.54Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2
61.54Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
61.54Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/&β;1/&γ;2
61.54Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
61.54Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2
61.54Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
61.54Single8GEAEpinephrine8GEA-β2-Epinephrine-Gs/&β;1/&γ;2
61.54Single8GEDEpinephrine8GED-β2-Epinephrine-Gs/&β;1/&γ;2
61.54Single8GG7Epinephrine8GG7-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
61.54Single8GGWEpinephrine8GGW-β2-Epinephrine
61.54Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/&β;1/&γ;2
61.54Single8UNLEpinephrine8UNL-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
61.54Single8UNOEpinephrine8UNO-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
61.54Single8UNTEpinephrine8UNT-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
61.54Single8UNUEpinephrine8UNU-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
61.54Single8UO3Epinephrine8UO3-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
61.54Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
61.54Consensusalpha1_onOrthosteric Ligandalpha1a_on
61.54Consensusalpha1a_onOrthosteric Ligand7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
61.11Single4AMJ(S)-Carvedilol4AMJ-β1-(S)-Carvedilol
61.11Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
61.11Consensusmop_offOrthosteric Ligand7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
60.00Single2Y00Dobutamine2Y00-β1-Dobutamine
60.00Single5C1MBU725C1M-μ-BU72
60.00Single5WIUNemonapride5WIU-D4-Nemonapride
60.00Single5WIVNemonapride5WIV-D4-Nemonapride-Na
60.00Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
60.00Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
60.00Single6PS6Timolol6PS6-β2-Timolol
60.00Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
60.00Single7C61Ergotamine7C61-5-HT1B-Ergotamine
60.00Single7CKXA776367CKX-D1-A77636-Gs/&β;1/&γ;2
60.00Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
60.00Single7SBFPZM217SBF-μ-PZM21-Gi1/&β;1/&γ;2
60.00Single8DZQmomSalB8DZQ-κ-momSalB-Go/&β;1/&γ;2
60.00Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
60.00Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
60.00Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide 6DRX-5-HT2B-Lisuride
60.00Consensusa1_on_alloOrthosteric Ligand7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
60.00Consensusalpha2a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
60.00Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
60.00Consensusd4_offOrthosteric Ligand5WIU-D4-Nemonapride
60.00Consensusd4_off_alloOrthosteric Ligand5WIV-D4-Nemonapride-Na
60.00Consensusgo_amineOrthosteric Ligandgo_adrenergic go_muscarinic go_5ht
60.00Consensusgo_opioidOrthosteric Ligand8DZQ-κ-momSalB-Go/&β;1/&γ;2
58.82Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
58.82Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/&β;1/&γ;2
58.82Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
58.82Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
58.82Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
58.33Single8GGREpinephrine8GGR-β2-Epinephrine
58.33Single8GGZEpinephrine8GGZ-β2-Epinephrine
58.33Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
58.33Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
57.89Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
57.14Single2YDOAdenosine2YDO-A2A-Adenosine
57.14Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
57.14Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
57.14Single6TPGEMPA6TPG-OX2-EMPA
57.14Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/&β;1/&γ;2
57.14Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
57.14Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/&β;1/&γ;2
57.14Single7JOZVFP7JOZ-D1-VFP-Gs/&β;1/&γ;2
57.14Single8GDZEpinephrine8GDZ-β2-Epinephrine-Gs/&β;1/&γ;2
57.14Single8GG8Epinephrine8GG8-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
57.14Single8GGLEpinephrine8GGL-β2-Epinephrine
57.14Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
57.14Single8JLNT1AM8JLN-TA1-T1AM-Gs/&β;1/&γ;2
57.14Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
57.14Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
57.14Single8UHBRO52563908UHB-TA1-RO5256390-Gs/&β;1/&γ;2
57.14Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
57.14Consensusalpha2b_onOrthosteric Ligand6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
56.25Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
56.25Single4RWADIPP-NH24RWA-δ-DIPP-NH2
56.25Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
56.25Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
56.25Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
56.25Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2
56.25Single7JV5SKF812977JV5-D1-SKF81297-Gs/&β;1/&γ;2
56.25Single8DZPmomSalB8DZP-κ-momSalB-Gi1/&β;1/&γ;2
56.25Single8E0GBU728E0G-μ-BU72
56.25Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
56.25Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
56.25Single8JXVClozapine8JXV-H4-Clozapine-Gi1/&β;1/&γ;2
56.25Consensus5ht5_offOrthosteric Ligand5ht5a_off
56.25Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
56.25Consensusgo_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
56.25Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A2A-NECA-Gs/&β;1/&γ;1 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
56.25Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
56.25Consensush1_offOrthosteric Ligand3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole 8X63-H1-Mepyramine 8X64-H1-Desloratadine
56.25Consensushistamine_offOrthosteric Ligandh1_off
55.56Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
55.56Single8X5YAstemizole8X5Y-H1-Astemizole
53.85Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
53.85Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2
53.85Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2
53.85Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/&β;1/&γ;2
53.85Single8EF6Morphine8EF6-μ-Morphine-Gi1/&β;1/&γ;2
53.85Single8GGCEpinephrine8GGC-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
53.85Single8GGEEpinephrine8GGE-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
53.85Single8GH1Epinephrine8GH1-β2-Epinephrine
53.85Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
53.85Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
53.85Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/&β;1/&γ;2
53.85Consensus5ht4_onOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
53.33Single4EJ4Naltrindole4EJ4-δ-Naltrindole
53.33Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
53.33Single4X1HNonyl Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
53.33Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
53.33Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
53.33Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
53.33Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
53.33Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
53.33Single7SCGFH2107SCG-μ-FH210-Gi1/&β;1/&γ;2
53.33Single7T2GMitragynine pseudoindoxyl7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
53.33Single7UL4Alvimopan7UL4-μ-Alvimopan
53.33Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/&β;1/&γ;2
53.33Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
53.33Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
53.33Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
53.33Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2
53.33Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/&β;1/&γ;2
53.33Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
53.33Single8X64Desloratadine8X64-H1-Desloratadine
53.33Consensus5ht1a_onOrthosteric Ligand8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
53.33Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
53.33Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
53.33Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
53.33Consensusadenosine_onOrthosteric Liganda1_on a2_on
53.33Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
53.33Consensusnucleotide_onOrthosteric Ligandadenosine_on
52.94Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
52.94Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
52.94Single6MXTSalmeterol6MXT-β2-Salmeterol
52.94Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
52.94Single7YITNalfurafine7YIT-κ-Nalfurafine
52.94Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
52.94Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
52.63Single4IARErgotamine4IAR-5-HT1B-Ergotamine
52.63Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
50.00Single2X72All-trans-retinal2X72-Rhodopsin-All-trans-retinal-Gt(CT)
50.00Single3QAKUK-4320973QAK-A2A-UK-432097
50.00Single3VGAZM2413853VGA-A2A-ZM241385-Antibody
50.00Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
50.00Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
50.00Single5WQCEMPA5WQC-OX2-EMPA
50.00Single6AKXA4R6AKX-CCR5-A4R
50.00Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
50.00Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/&β;1/&γ;2
50.00Single6DDFDamgo6DDF-μ-Damgo-Gi1/&β;1/&γ;2
50.00Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
50.00Single6GDGNECA6GDG-A2A-NECA-Gs/&β;1/&γ;1
50.00Single6HLOAprepitant6HLO-NK1-Aprepitant
50.00Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
50.00Single6ME2Ramelteon6ME2-MT1-Ramelteon
50.00Single6NWEOctyl Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
50.00Single6TODEMPA6TOD-OX1-EMPA-Na
50.00Single6TP6Filorexant6TP6-OX1-Filorexant
50.00Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
50.00Single7CFNINT-7777CFN-GPBA-INT-777-Gs/&β;1/&γ;2
50.00Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2
50.00Single7EZCUKA7EZC-A2A-UKA
50.00Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;1
50.00Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
50.00Single7UM4AS26747237UM4-5-HT5A-AS2674723
50.00Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
50.00Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
50.00Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2
50.00Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
50.00Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
50.00Single8E9YPubChem 4466038E9Y-M3-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
50.00Single8EFOPZM218EFO-μ-PZM21-Gi1/&β;1/&γ;2
50.00Single8GGFEpinephrine8GGF-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
50.00Single8IW4Spermidine8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2
50.00Single8IWESpermidine8IWE-TAAR9-Spermidine
50.00Single8J19PubChem 1270454228J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
50.00Single8UO1Epinephrine8UO1-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
50.00Consensus5ht2_onOrthosteric Ligand5ht2a_on 5ht2c_on
50.00Consensus5ht5a_offOrthosteric Ligand7UM4-5-HT5A-AS2674723
50.00Consensusa2a_onOrthosteric Ligand6GDG-A2A-NECA-Gs/&β;1/&γ;1
50.00Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
50.00Consensusendothelin_offOrthosteric Ligandetb_off
50.00Consensusetb_offOrthosteric Ligand5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500 5X93-ETB-K-8794
50.00Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
50.00Consensusgs_5htOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2 7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2 7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
50.00Consensushca2_on_alloOrthosteric Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
47.83Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
47.62Single5WF5UK-4320975WF5-A2A-UK-432097
47.62Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
47.37Single5WF6UK-4320975WF6-A2A-UK-432097
47.37Single6PT3DPI-2876PT3-δ-DPI-287
47.37Single7XY6PubChem 117178317XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
47.37Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
47.06Single4DJHJDTic4DJH-κ-JDTic
47.06Single4U15Tiotropium4U15-M3-Tiotropium
47.06Single5V54Methiothepin5V54-5-HT1B-Methiothepin
47.06Single5X93K-87945X93-ETB-K-8794
47.06Single6OL9Tiotropium6OL9-M5-Tiotropium
47.06Single6TQ7SB-3348676TQ7-OX1-SB-334867
47.06Single7B6WCyclazosin7B6W-α1b-Cyclazosin
47.06Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
47.06Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2
47.06Single8EFLSR170188EFL-μ-SR17018-Gi1/&β;1/&γ;2
47.06Single8G056-OAU8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
47.06Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
47.06Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
47.06Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
47.06Single8JXWVUF68848JXW-H4-VUF6884-Gi1/&β;1/&γ;2
47.06Consensus5ht1_offOrthosteric Ligand5ht1b_off
47.06Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
47.06Consensus5ht1b_onOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
47.06Consensusalpha1b_offOrthosteric Ligand7B6W-α1b-Cyclazosin
47.06Consensusgs_compl-peptideOrthosteric Ligand8I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
47.06Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
47.06Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
47.06Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
47.06Consensusnk1_offOrthosteric Ligand6J20-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
46.67Single3UZCPubChem 1355666093UZC-A2A-PubChem 135566609
46.67Single4DKLBeta-funaltrexamine4DKL-μ-Beta-funaltrexamine
46.67Single4MBSMaraviroc4MBS-CCR5-Maraviroc
46.67Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
46.67Single4ZJCSB-6740424ZJC-OX1-SB-674042
46.67Single5TE3Octyl Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
46.67Single6A94Zotepine6A94-5-HT2A-Zotepine
46.67Single6DS0Ly2660976DS0-5-HT2B-Ly266097
46.67Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
46.67Single6TPNHTL66416TPN-OX2-HTL6641
46.67Single6VI4JDTic6VI4-κ-JDTic
46.67Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
46.67Single7CMVPD1289077CMV-D3-PD128907-Gi1/&β;1/&γ;2
46.67Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2
46.67Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
46.67Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
46.67Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
46.67Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2
46.67Consensus5ht2a_onOrthosteric Ligand7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
46.67Consensusdop_off_alloOrthosteric Ligand4N6H-δ-Naltrindole-Na
46.67Consensusox1_offOrthosteric Ligand6TOT-OX1-Lemborexant 6TP4-OX1-ACT-462206 6TP6-OX1-Filorexant 6V9S-OX1-GTPL11403 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ7-OX1-SB-334867 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant
46.67Consensusox2_offOrthosteric Ligand6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant
46.67Consensussensory_offOrthosteric Ligandopsin_off
46.15Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
46.15Single3UZAGTPL92363UZA-A2A-GTPL9236
46.15Single6FUFAll-trans-retinal6FUF-Rhodopsin-All-trans-retinal-Go/&β;1/&γ;2
46.15Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/&β;1/&γ;2
46.15Single8J6QBeta-hydroxybutyrate8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
46.15Single8POKHistamine8POK-H2-Histamine-Gs/&β;1/&γ;2
45.00Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
45.00Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
45.00Single8G59TUG-8918G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
45.00Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
44.44Single5CXVTiotropium5CXV-M1-Tiotropium
44.44Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
44.44Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
44.44Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
44.44Single7XMTJ-21567XMT-SST4-J-2156-Gi1/&β;1/&γ;2
44.44Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
44.44Single8I95EP548I95-C3aB-EP54-Go/&β;1/&γ;2
44.44Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2
44.44Single8IJDMK68928IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
44.44Single8JWYPubChem 1684517108JWY-A2A-PubChem 168451710
44.44Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/&β;1/&γ;2
44.44Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
44.44Consensusgs_bileacidOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
44.44Consensusgs_steroidOrthosteric Ligandgs_bileacid
44.44Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
44.44Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
43.75Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
43.75Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
43.75Single4U16N-Methyl Scopolamine4U16-M3-N-Methyl Scopolamine
43.75Single5YC8N-Methyl Scopolamine5YC8-M2-N-Methyl Scopolamine
43.75Single5ZK8N-Methyl Scopolamine5ZK8-M2-N-Methyl Scopolamine
43.75Single5ZKCN-Methyl Scopolamine5ZKC-M2-N-Methyl Scopolamine
43.75Single6DRXLisuride6DRX-5-HT2B-Lisuride
43.75Single6TOTLemborexant6TOT-OX1-Lemborexant
43.75Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
43.75Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/&β;1/&γ;2
43.75Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
43.75Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
43.75Single8CU6LJ-45178CU6-A2A-LJ-4517
43.75Single8EFQDamgo8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
43.75Single8J18(3R)-3-hydroxydodecanoic acid8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
43.75Single8X63Mepyramine8X63-H1-Mepyramine
43.75Consensusgi_hcaOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
43.75Consensusgi_hcarOrthosteric Ligandgi_hca
43.75Consensusgo_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
43.75Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
43.75Consensushca2_onOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
43.75Consensushistamine_onOrthosteric Ligandh1_on h4_on
42.86Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
42.86Single6HLLCP999946HLL-NK1-CP99994
42.86Single6QNOAll-trans-retinal6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
42.86Single6TP4ACT-4622066TP4-OX1-ACT-462206
42.86Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
42.86Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
42.86Single7SRQLSD7SRQ-5-HT2B-LSD
42.86Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
42.86Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
42.86Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2
42.86Single8IJANiacin8IJA-HCA2-Niacin-Gi1/&β;1/&γ;2
42.86Single8IY9Niacin8IY9-HCA2-Niacin-Go/&β;1/&γ;2
42.86Single8K5BNiacin8K5B-HCA2-Niacin
42.86Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
42.86Consensusalpha1_offOrthosteric Ligandalpha1a_off alpha1b_off
42.86Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
42.86Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
42.86Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
42.86Consensusox1_off_alloOrthosteric Ligand6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na 6TO7-OX1-Suvorexant-Na
42.11Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
42.11Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
42.11Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
42.11Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
42.11Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
42.11Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
42.11Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
42.11Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
42.11Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
42.11Single7XK2MK68927XK2-HCA2-MK6892-Gi1/&β;1/&γ;2
42.11Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
42.11Consensusbileacid_onOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
42.11Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
42.11Consensussteroid_onOrthosteric Ligandbileacid_on
41.67Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
41.67Single8GEJEpinephrine8GEJ-β2-Epinephrine-Gs/&β;1/&γ;2
41.67Single8PWNTheophylline8PWN-A2A-Theophylline
41.67Consensusgabab_offOther Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
41.18Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
41.18Single5NM2ZM2413855NM2-A2A-ZM241385-Na
41.18Single5XPRBosentan5XPR-ETB-Bosentan
41.18Single5ZK3Quinuclidinyl benzilate hydrobromide5ZK3-M2-Quinuclidinyl benzilate hydrobromide
41.18Single6DDEDamgo6DDE-μ-Damgo-Gi1/&β;1/&γ;2
41.18Single6LUQHaloperidol6LUQ-D2-Haloperidol
41.18Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
41.18Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
41.18Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
41.18Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
41.18Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2
41.18Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
41.18Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
41.18Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
41.18Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
41.18Consensusgs_muscarinicOrthosteric Ligand8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
41.18Consensusm2_offOrthosteric Ligand5ZKB-M2-AF-DX 384 5ZKC-M2-N-Methyl Scopolamine 5ZK3-M2-Quinuclidinyl benzilate hydrobromide
41.18Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
40.91Single6PT2KGCHM076PT2-δ-KGCHM07
40.91Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
40.91Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
40.00Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
40.00Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
40.00Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
40.00Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
40.00Single5DHHSB-6121115DHH-NOP-SB-612111
40.00Single5K2DZM2413855K2D-A2A-ZM241385
40.00Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
40.00Single5WS3EMPA5WS3-OX2-EMPA
40.00Single5ZTYAM102575ZTY-CB2-AM10257
40.00Single6AKYMaraviroc6AKY-CCR5-Maraviroc
40.00Single6B73PubChem 1319551386B73-κ-PubChem 131955138
40.00Single6JZHZM2413856JZH-A2A-ZM241385-Na
40.00Single6OYAAll-trans-retinal6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
40.00Single6PS7ZM2413856PS7-A2A-ZM241385-Na
40.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
40.00Single7SK9CCX6627SK9-ACKR3-CCX662
40.00Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
40.00Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
40.00Single7XN9L-054,5227XN9-SST2-L-054,522
40.00Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
40.00Single8GNGIstradefylline8GNG-A2A-Istradefylline
40.00Single8HOCImetit8HOC-H4-Imetit-Gi1/&β;1/&γ;2
40.00Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
40.00Consensus5ht2c_onOrthosteric Ligand8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
40.00Consensusa2a_off_alloOrthosteric Ligand6ZDR-A2A-HMS1413f12-Na 6GT3-A2A-Imaradenant-Na 8CU7-A2A-LJ-4517-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PubChem 92460631; psb36-Na 5MZJ-A2A-Theophylline-Na 5OLO-A2A-Tozadenant-Na 5OLH-A2A-Vipadenant-Na 5NM4-A2A-ZM241385-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5MZP-A2A-Caffeine-Na 8CIC-A2A-Etrumadenant-Na
40.00Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
40.00Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
40.00Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
40.00Consensusgi_histamineOrthosteric Ligand8HN8-H4-Histamine-Gi1/&β;1/&γ;2 8HOC-H4-Imetit-Gi1/&β;1/&γ;2
40.00Consensusgs_histamineOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
40.00Consensusgt_class-aOrthosteric Ligandgt_opsin
40.00Consensusgt_opsinOrthosteric Ligandgt_sensory
40.00Consensusgt_sensoryOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
40.00Consensush4_onOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
40.00Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
40.00Consensuslpl_offOrthosteric Ligands1p_off lpa_off
40.00Consensuslpl_onOrthosteric Ligands1p_on lpa_on
40.00Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
40.00Consensusmelatonin_onOrthosteric Ligandmt1_on mt2_on
40.00Consensusopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
40.00Consensusorexin_offOrthosteric Ligandox2_off ox1_off
40.00Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
39.13Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
39.13Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
38.89Single3UONQuinuclidinyl benzilate hydrobromide3UON-M2-Quinuclidinyl benzilate hydrobromide
38.89Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
38.89Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
38.89Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
38.89Single6J20Aprepitant6J20-NK1-Aprepitant
38.89Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
38.89Single7EW7PubChem 40774607EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
38.89Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
38.89Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
38.89Single7TUYGSK682753A7TUY-GPR183-GSK682753A
38.89Single7W41PD1762527W41-BB2-PD176252
38.89Single7XTQR3997XTQ-GPBA-R399-Gs/&β;1/&γ;2
38.89Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
38.89Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2
38.89Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
38.89Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
38.89Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2
38.89Single8JD0J9R8JD0-mGlu2; mGlu3-Glutamate-J9R
38.89Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/&β;1/&γ;2
38.89Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
38.89Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
38.89Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
38.89Consensusadenosine_offOrthosteric Liganda1_off a2_off
38.89Consensusangiotensin_offOrthosteric Ligandat1_off at2_off
38.89Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
38.89Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
38.89Consensusbombesin_offOrthosteric Ligandbb2_off
38.89Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
38.89Consensusffa4_onOrthosteric Ligand8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
38.89Consensusgs_ffaOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2 8GDB-EP4-PGE2-Gs/&β;1/&γ;2
38.89Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
38.89Consensuslpa_offOrthosteric Ligandlpa1_off
38.89Consensuslpa_onOrthosteric Ligandlpa1_on
38.89Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl Scopolamine 5ZHP-M3-PubChem 134828589
38.89Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
38.89Consensussst4_onOrthosteric Ligand7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
38.46Single6OY9All-trans-retinal6OY9-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
38.46Single7MTBAll-trans-retinal7MTB-Rhodopsin-All-trans-retinal-GRK1
38.46Single8A2OTheophylline8A2O-A2A-Theophylline-Na
38.46Single8IWM2-Phenylethylamine8IWM-TAAR9-2-Phenylethylamine
38.46Single8WC5Tetramethylammonium ion8WC5-TA1-Tetramethylammonium ion-chim(NtGi1-Gs)/&β;1/&γ;2
38.46Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
38.46Consensussensory_onOrthosteric Ligandopsin_on
38.10Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
38.10Single7F8XNN90567F8X-CCKA-NN9056
38.10Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
38.10Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
38.10Single8J6RMK68928J6R-HCA2-MK6892-Gi1/&β;1/&γ;2
38.10Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
38.10Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
38.10Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
38.10Consensussst_onOrthosteric Ligandsst2_on sst4_on
37.50Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
37.50Single3RZECidoxepin3RZE-H1-Cidoxepin
37.50Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
37.50Single5IU4ZM2413855IU4-A2A-ZM241385-Na
37.50Single5IU7Q274563465IU7-A2A-Q27456346-Na
37.50Single5IUBQ274563445IUB-A2A-Q27456344-Na
37.50Single5JTBZM2413855JTB-A2A-ZM241385
37.50Single5K2BZM2413855K2B-A2A-ZM241385-Na
37.50Single5K2CZM2413855K2C-A2A-ZM241385-Na
37.50Single5NLXZM2413855NLX-A2A-ZM241385-Na
37.50Single5NM4ZM2413855NM4-A2A-ZM241385-Na
37.50Single6AQFZM2413856AQF-A2A-ZM241385
37.50Single6IQLL7458706IQL-D4-L745870
37.50Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
37.50Single6TP3Nemorexant6TP3-OX1-Nemorexant
37.50Single6V9SGTPL114036V9S-OX1-GTPL11403
37.50Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
37.50Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
37.50Single7AROLUF58337ARO-A2A-LUF5833-Na
37.50Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
37.50Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
37.50Single7KH0Acyclovir triphosphate7KH0-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
37.50Single7T32ZM2413857T32-A2A-ZM241385
37.50Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
37.50Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2
37.50Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
37.50Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
37.50Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
37.50Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
37.50Single8GURPubChem 1048958GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2
37.50Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
37.50Single8JERAcipimox8JER-HCA2-Acipimox-Go/&β;1/&γ;2
37.50Single8JHNMMF8JHN-HCA2-MMF-Go/&β;1/&γ;2
37.50Single8JIMMMF8JIM-HCA2-MMF-Gi1/&β;1/&γ;2
37.50Single8K5CAcipimox8K5C-HCA2-Acipimox
37.50Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
37.50Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6WH4-5-HT2A-Methiothepin 7VOE-5-HT2A-Aripiprazole 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 6A93-5-HT2A-Risperidone
37.50Consensusbombesin_onOrthosteric Ligandbb2_on bb1_on
37.50Consensusgi_melatoninOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
37.50Consensush3_on_alloOrthosteric Ligand7F61-H3-PF-03654746-Cholesterol
37.50Consensushca_onOrthosteric Ligandhca2_on hca3_on
37.50Consensushcar_onOrthosteric Ligandhca_on
37.50Consensusm1_off_alloOrthosteric Ligand6WJC-M1-Atropine-Muscarinic toxin 7
37.50Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
37.04Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
37.04Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
37.04Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
36.84Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
36.84Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
36.84Single6A93Risperidone6A93-5-HT2A-Risperidone
36.84Single6CM4Risperidone6CM4-D2-Risperidone
36.84Single6HLPNetupitant6HLP-NK1-Netupitant
36.84Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
36.84Single7DFPSpiperone7DFP-D2-Spiperone
36.84Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/&β;1/&γ;2
36.84Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
36.84Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
36.84Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
36.84Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
36.84Single7Y24Octreotide7Y24-SST2-Octreotide-Go/&β;1/&γ;2
36.84Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2
36.84Single8JWZAB9288JWZ-A2A-AB928-Na
36.84Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
36.84Single8WU1KCA8WU1-CB1-KCA-Arrestin1
36.84Consensusat2_offOrthosteric Ligand7JNI-AT2-Olodanrigan
36.84Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
36.84Consensusgi_class-fOther Ligandgi_frizzled
36.84Consensusgi_frizzledOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
36.84Consensusgs_trhOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
36.84Consensusleuko_offOrthosteric Ligandblt_off cyslt_off
36.84Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
36.36Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
36.36Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
36.36Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
36.36Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
36.00Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
36.00Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
36.00Consensusbb1_onOrthosteric Ligand8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
35.71Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
35.71Single5WKTOctyl Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
35.71Single6ME5Agomelatine6ME5-MT1-Agomelatine
35.71Single6ME9Ramelteon6ME9-MT2-Ramelteon
35.71Single7MT8All-trans-retinal7MT8-Rhodopsin-All-trans-retinal-GRK1
35.71Single7MT9All-trans-retinal7MT9-Rhodopsin-All-trans-retinal-GRK1
35.71Single7MTAAll-trans-retinal7MTA-Rhodopsin-All-trans-retinal-GRK1
35.71Single7WC5Psilocin7WC5-5-HT2A-Psilocin
35.71Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
35.71Single8IW72-Phenylethylamine8IW7-TAAR9-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
35.71Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/&β;1/&γ;2
35.71Consensusopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
35.29Single3EMLZM2413853EML-A2A-ZM241385
35.29Single4DAJTiotropium4DAJ-M3-Tiotropium
35.29Single4EIYZM2413854EIY-A2A-ZM241385-Na
35.29Single4MQSIperoxo4MQS-M2-Iperoxo
35.29Single4U14Tiotropium4U14-M3-Tiotropium
35.29Single5DHGPubChem 250014125DHG-NOP-PubChem 25001412
35.29Single5DSGTiotropium5DSG-M4-Tiotropium
35.29Single5IU8Q274563475IU8-A2A-Q27456347-Na
35.29Single5K2AZM2413855K2A-A2A-ZM241385-Na
35.29Single5OLGZM2413855OLG-A2A-ZM241385-Na
35.29Single5UENDU1725UEN-A1-DU172
35.29Single5UIGJ3.651.884G5UIG-A2A-J3.651.884G
35.29Single5VRAZM2413855VRA-A2A-ZM241385-Na
35.29Single6LPJZM2413856LPJ-A2A-ZM241385-Na
35.29Single6LPKZM2413856LPK-A2A-ZM241385-Na
35.29Single6S0LZM2413856S0L-A2A-ZM241385
35.29Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
35.29Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
35.29Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
35.29Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
35.29Single7PYRPSB-21157PYR-A2A-PSB-2115
35.29Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
35.29Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
35.29Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
35.29Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
35.29Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
35.29Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/&β;1/&γ;2
35.29Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
35.29Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
35.29Consensusa2_offOrthosteric Liganda2a_off
35.29Consensusa2a_offOrthosteric Ligand8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 5UIG-A2A-J3.651.884G 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-PubChem 168451710 5K2D-A2A-ZM241385
35.29Consensushca3_onOrthosteric Ligand8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
35.29Consensusm2_on_alloOrthosteric Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
35.29Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
35.29Consensusm4_on_alloOrthosteric Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
35.29Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
35.29Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
35.29Consensustachykinin_offOrthosteric Ligandnk1_off
35.00Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
35.00Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
35.00Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
35.00Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
35.00Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
35.00Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
35.00Single8GAGYVF8GAG-CB1-YVF-Gi1/&β;1/&γ;2
35.00Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/&β;1/&γ;2
35.00Single8ID8TUG-8918ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
35.00Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
35.00Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
35.00Consensusffa4_on_alloOrthosteric Ligand8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
35.00Consensusgs_orexinOrthosteric Ligand7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
35.00Consensusorexin_onOrthosteric Ligandox2_on
34.78Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
34.78Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
34.78Consensusangiotensin_onOrthosteric Ligandat1_on
34.78Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
33.33Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
33.33Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
33.33Single2G87All-trans-retinal2G87-Rhodopsin-All-trans-retinal
33.33Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
33.33Single4WW3All-trans-retinal4WW3-Rhodopsin-All-trans-retinal
33.33Single5IUAQ274563485IUA-A2A-Q27456348-Na
33.33Single5MZPCaffeine5MZP-A2A-Caffeine-Na
33.33Single5N2RPubChem 92460631; psb365N2R-A2A-PubChem 92460631; psb36-Na
33.33Single5N2SPSB365N2S-A1-PSB36
33.33Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
33.33Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
33.33Single6D26Fevipiprant6D26-DP2-Fevipiprant
33.33Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
33.33Single6LPLZM2413856LPL-A2A-ZM241385-Na
33.33Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
33.33Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
33.33Single6S0QZM2413856S0Q-A2A-ZM241385
33.33Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
33.33Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
33.33Single6WQAZM2413856WQA-A2A-ZM241385-Na
33.33Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
33.33Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
33.33Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
33.33Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
33.33Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
33.33Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
33.33Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
33.33Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
33.33Single7RM5ZM2413857RM5-A2A-ZM241385-Na
33.33Single7SINNPS-21437SIN-CaS-NPS-2143
33.33Single7SINNPS-21437SIN-CaS-NPS-2143
33.33Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
33.33Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2
33.33Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
33.33Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
33.33Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
33.33Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
33.33Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
33.33Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
33.33Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
33.33Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
33.33Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
33.33Single8EA0Iperoxo8EA0-M3-Iperoxo
33.33Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
33.33Single8FEGPRD_0025178FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
33.33Single8FYNZM2413858FYN-A2A-ZM241385-Na
33.33Single8GNEKW-63568GNE-A2A-KW-6356-Na
33.33Single8HN8Histamine8HN8-H4-Histamine-Gi1/&β;1/&γ;2
33.33Single8ID9Eicosapentaenoic acid8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
33.33Single8IHFMK68928IHF-HCA2-MK6892-Gi1/&β;1/&γ;2
33.33Single8ITFDMCHA8ITF-TAAR9-DMCHA-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Single8IYHMK68928IYH-HCA2-MK6892-Go/&β;1/&γ;2
33.33Single8J6IMK68928J6I-HCA2-MK6892-Gi1/&β;1/&γ;2
33.33Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
33.33Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
33.33Single8QOTNanobody E8QOT-μ-Nanobody E
33.33Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
33.33Single8WCBCyclohexylammonium ion8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Single8WCCCyclohexylammonium ion8WCC-TA1-Cyclohexylammonium ion
33.33Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
33.33Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
33.33Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2 8I95-C3aB-EP54-Go/&β;1/&γ;2
33.33Consensuscb2_onOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
33.33Consensusgi_somatostatinOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
33.33Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
33.33Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
33.33Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
33.33Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
33.33Consensusmt1_onOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
33.33Consensusmt2_onOrthosteric Ligand7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
33.33Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
33.33Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
32.00Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
32.00Consensusbk1_onOrthosteric Ligand7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
32.00Consensusgs_bradykininOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.82Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
31.82Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
31.82Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
31.82Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
31.82Single8GHVPubChem 1459649038GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
31.82Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
31.82Consensussst2_onOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
31.58Single5XR8AM8415XR8-CB1-AM841
31.58Single5XRAAM115425XRA-CB1-AM11542
31.58Single6E59L-7607356E59-NK1-L-760735
31.58Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
31.58Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
31.58Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
31.58Single7EPENAM5637EPE-mGlu-NAM563
31.58Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
31.58Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2
31.58Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
31.58Single7PX4PSB-21137PX4-A2A-PSB-2113
31.58Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
31.58Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
31.58Single7WV9PubMed 1048957WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
31.58Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
31.58Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
31.58Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2
31.58Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/&β;1/&γ;2
31.58Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
31.58Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
31.58Consensuscck_onOrthosteric Ligandccka_on cckb_on
31.58Consensuscyslt1_off_ortoalloOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
31.58Consensusgi_ffaOrthosteric Ligand8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
31.58Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
31.25Single3PWHZM2413853PWH-A2A-ZM241385
31.25Single3VG9ZM2413853VG9-A2A-ZM241385-Antibody
31.25Single4S0VSuvorexant4S0V-OX2-Suvorexant
31.25Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
31.25Single6TPJSuvorexant6TPJ-OX2-Suvorexant
31.25Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
31.25Single7F8ULintitript7F8U-CCKA-Lintitript
31.25Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
31.25Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
31.25Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
31.25Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
31.25Single7TUZ7alpha,25-dihydroxycholesterol7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
31.25Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
31.25Single7XRRLemborexant7XRR-OX2-Lemborexant
31.25Single8A6CAll-trans-retinal8A6C-Rhodopsin-All-trans-retinal
31.25Single8A6DAll-trans-retinal8A6D-Rhodopsin-All-trans-retinal
31.25Single8A6EAll-trans-retinal8A6E-Rhodopsin-All-trans-retinal
31.25Single8IHKAcifran8IHK-HCA3-Acifran
31.25Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2
31.25Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/&β;1/&γ;2
31.25Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
31.25Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
31.25Consensusmglu_onOther Ligandmglu2_on mglu4_on
30.77Single3PXOAll-trans-retinal3PXO-Rhodopsin-All-trans-retinal
30.77Single5DYSAll-trans-retinal5DYS-Rhodopsin-All-trans-retinal
30.77Single7WC4Serotonin7WC4-5-HT2A-Serotonin
30.77Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
30.77Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
30.43Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
30.43Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
30.43Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
30.43Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
30.43Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
30.43Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
30.43Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
30.00Single4N4WSANT-14N4W-SMO-SANT-1
30.00Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
30.00Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
30.00Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
30.00Single6ZG4HTL00099366ZG4-M1-HTL0009936
30.00Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.00Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
30.00Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
30.00Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
30.00Single7WCNAR2314537WCN-GPR119-AR231453-Gs/&β;1/&γ;2
30.00Consensuscannabinoid_onOrthosteric Ligandcb1_on cb2_on
30.00Consensuscb1_onOrthosteric Ligand8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
30.00Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
30.00Consensusdp_offOrthosteric Liganddp2_off
30.00Consensusgi_cannabinoidOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
30.00Consensuspeptide_offOrthosteric Ligandopioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
30.00Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
29.63Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.63Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
29.63Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
29.63Consensusendothelin_onOrthosteric Ligandetb_on eta_on
29.41Single3REYPubChem 56973REY-A2A-PubChem 5697
29.41Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
29.41Single5UVIZM2413855UVI-A2A-ZM241385
29.41Single6MH8ZM2413856MH8-A2A-ZM241385
29.41Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
29.41Single6ZDVPubChem 9840736ZDV-A2A-PubChem 984073-Na
29.41Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
29.41Single7BB6Acyclovir triphosphate7BB6-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
29.41Single7VODCariprazine7VOD-5-HT2A-Cariprazine
29.41Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
29.41Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
29.41Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
29.41Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2
29.41Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2
29.41Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.41Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
29.41Consensusffa2_onOrthosteric Ligand8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
29.41Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
29.41Consensuss1p_offOrthosteric Ligands1p1_off
29.17Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1
29.17Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
29.17Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;2
29.17Consensusgi_chemerinOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
29.17Consensusgi_formylpeptideOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
29.03Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
28.57Single3RFMCaffeine3RFM-A2A-Caffeine
28.57Single6IGLIRL16206IGL-ETB-IRL1620
28.57Single6K1QIRL25006K1Q-ETB-IRL2500
28.57Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
28.57Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
28.57Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2
28.57Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
28.57Single7VGXNeuropeptide Y7VGX-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
28.57Single7XZ6APD6687XZ6-GPR119-APD668-Gs/&β;1/&γ;2
28.57Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
28.57Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.57Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
28.57Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
28.57Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
28.57Single8WRZ8D08WRZ-CB1-8D0-Arrestin1
28.57Consensuscckb_onOrthosteric Ligand7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
28.57Consensusfpa_onOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.57Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
28.57Consensusgs_endothelinOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
28.57Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
28.00Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
28.00Single6JODAngiotensin II6JOD-AT2-Angiotensin II
28.00Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
28.00Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
28.00Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
28.00Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
27.78Single4YAYZD-71554YAY-AT1-ZD-7155
27.78Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
27.78Single5TGZAM65385TGZ-CB1-AM6538
27.78Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2
27.78Single7CFMP3957CFM-GPBA-P395-Gs/&β;1/&γ;2
27.78Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
27.78Single7V3ZPubMed 1048957V3Z-CB1-PubMed 104895
27.78Single7VKTLTB47VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
27.78Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
27.78Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
27.78Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/&β;1/&γ;2
27.78Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
27.78Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
27.78Single8K5DGSK2560738K5D-HCA2-GSK256073
27.78Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
27.78Consensusblt_onOrthosteric Ligandblt1_on
27.78Consensuscb1_on_alloOrthosteric Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
27.78Consensusffa_onOrthosteric Ligandffa4_on ffa1_on ffa2_on ffa3_on
27.78Consensusfsh_on_alloOther Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
27.78Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
27.78Consensusleuko_onOrthosteric Ligandblt_on
27.78Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
27.59Single5GLHEndothelin-15GLH-ETB-Endothelin-1
27.59Single6IGKEndothelin-36IGK-ETB-Endothelin-3
27.27Single5EE7MK08935EE7-Glucagon-MK0893
27.27Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
27.27Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
27.27Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.27Single8XZFWN5618XZF-Apelin-WN561-Gi1/&β;1/&γ;2
27.27Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
27.27Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
27.27Consensusgs_bombesinOrthosteric Ligand8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.92Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
26.92Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
26.92Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
26.92Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
26.92Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
26.92Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
26.92Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.92Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
26.92Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
26.67Single3PQRAll-trans-retinal3PQR-Rhodopsin-All-trans-retinal-Gt(CT)
26.67Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
26.67Single8F76-8F76-OR51E2-Gs/&β;1/&γ;2
26.67Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
26.67Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/&β;1/&γ;2
26.67Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
26.67Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
26.67Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
26.67Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
26.32Single5CGCHTL142425CGC-mGlu5-HTL14242
26.32Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
26.32Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
26.32Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
26.32Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
26.32Single7C4SS1P7C4S-S1P3-S1P
26.32Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
26.32Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
26.32Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
26.32Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.32Single7Y27Somatostatin-147Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.32Single7YXAONO-54306087YXA-S1P5-ONO-5430608
26.32Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2
26.32Consensusgs_sstOrthosteric Ligand7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.32Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
26.09Single7QA8Peptide7QA8-STE2-Peptide
26.09Single7QA8Peptide7QA8-STE2-Peptide
26.09Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
26.09Consensusclass-d_offOrthosteric Ligandste2_off
26.09Consensusfpr-alx_onOrthosteric Ligandfpr1-alx_on fpr2-alx_on
26.09Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
26.09Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
25.93Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
25.93Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
25.93Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.93Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
25.93Consensusgi_neuromedinOrthosteric Ligand7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
25.93Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
25.93Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
25.00Single3AYMAll-trans-retinal3AYM-Rhodopsin-All-trans-retinal
25.00Single3OE9IT1t3OE9-CXCR4-IT1t
25.00Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
25.00Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
25.00Single7FEEPubMed 1048957FEE-CB1-PubMed 104895-ZCZ011
25.00Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
25.00Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
25.00Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
25.00Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
25.00Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
25.00Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
25.00Single7XOWGastrin7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
25.00Single7XOXCholecystokinin-87XOX-CCKB-Cholecystokinin-8-Gq/&β;1/&γ;2
25.00Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
25.00Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
25.00Single8GUSHU-3088GUS-CB2-HU-308-Gi1/&β;1/&γ;2
25.00Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
25.00Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2
25.00Single8JILNiacin8JIL-HCA2-Niacin-Gi1/&β;1/&γ;2
25.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
25.00Single8X79MRE-2698X79-I2-MRE-269-Gs/&β;1/&γ;2
25.00Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
25.00Consensusetb_onOrthosteric Ligand8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
25.00Consensusgi_muscarinicOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
25.00Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
25.00Consensusgo_class-b1Orthosteric Ligandgo_crf
25.00Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
25.00Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
25.00Consensusnpy_offOrthosteric Ligandnpy2_off npy1_off
25.00Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
25.00Consensusrelaxin_onOrthosteric Ligandrxfp4_on
24.14Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
24.14Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
24.14Consensuscrf1_onOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
24.00Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
24.00Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
24.00Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
24.00Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
23.81Single6KQIPubMed 1048956KQI-CB1-PubMed 104895-ORG27569
23.81Single7K15MKD0467K15-BLT1-MKD046-Na
23.81Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
23.81Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
23.81Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
23.81Single7Y66BM2137Y66-C5a1-BM213-Gi1/&β;1/&γ;2
23.81Single8GCPPGE28GCP-EP4-PGE2-Gi1/&β;1/&γ;2
23.81Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.81Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2
23.81Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
23.81Single8J6DEP1418J6D-C3aB-EP141-Go/&β;1/&γ;2
23.81Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg3_on
23.81Consensusblt1_offOrthosteric Ligand7K15-BLT1-MKD046-Na
23.81Consensusblt_offOrthosteric Ligandblt1_off
23.81Consensuscb1_off_alloOrthosteric Ligand6KQI-CB1-PubMed 104895-ORG27569
23.81Consensusclass-b2_onOrthosteric Ligandadgrg_on
23.81Consensusgi_prostanoidOrthosteric Ligand8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GDC-EP3-PGE2-Gi1/&β;1/&γ;2 8GCM-EP4-L902688-Gi1/&β;1/&γ;2
23.81Consensusgpr119_onOrthosteric Ligand7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
23.81Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
23.81Consensusprostanoid_onOrthosteric Ligandep_on fpa_on
23.81Consensustsh_on_alloOther Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
23.53Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
23.53Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
23.53Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
23.53Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
23.53Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
23.53Single7W0OElabela7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
23.53Single8HMPPubChem 699214798HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
23.53Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
23.53Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
23.53Consensusffa3_on_alloOrthosteric Ligand8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
23.33Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
23.33Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
23.08Single4A4MAll-trans-retinal4A4M-Rhodopsin-All-trans-retinal-Gt(CT)
23.08Single5EN0All-trans-retinal5EN0-Rhodopsin-All-trans-retinal-Gt(CT)
23.08Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
23.08Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.08Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
23.08Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
23.08Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
22.73Single5CGDHTL142425CGD-mGlu5-HTL14242
22.73Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
22.73Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
22.73Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.73Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
22.73Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
22.73Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.73Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.73Consensusep4_onOrthosteric Ligand7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2
22.73Consensusgs_lipidOrthosteric Ligandgs_ffa gs_prostanoid
22.73Consensusgs_prostanoidOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.73Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.73Consensusot_onOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
22.58Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
22.58Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
22.22Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
22.22Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
22.22Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
22.22Single6TPKRetosiban6TPK-OT-Retosiban
22.22Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
22.22Single6ZG9GSK10347026ZG9-M1-GSK1034702
22.22Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
22.22Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
22.22Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
22.22Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
22.22Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
22.22Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
22.22Single8GCML9026888GCM-EP4-L902688-Gi1/&β;1/&γ;2
22.22Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.22Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.22Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
22.22Single8HQN9(S)-HODE8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
22.22Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
22.22Single8K4NVF08K4N-GPR34-VF0-Gi1/&β;1/&γ;2
22.22Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/&β;1/&γ;2
22.22Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
22.22Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.22Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
22.22Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
22.22Consensusvasopressin-ot_offOrthosteric Ligandot_off
21.88Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
21.74Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
21.74Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
21.74Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
21.74Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
21.74Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.74Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.74Consensusclass-d_offOrthosteric Ligandste2_off
21.74Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
21.74Consensusfpr2-alx_onOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
21.74Consensusgo_vasopressinOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
21.74Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.74Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
21.43Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/&β;1/&γ;2
21.43Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
21.43Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
21.43Single7XKEBetahydroxyandrosterone7XKE-ADGRG2-Betahydroxyandrosterone-chim(NtGi1-Gs)/&β;1/&γ;2
21.43Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
21.43Consensusclass-d_onOrthosteric Ligandste2_on
21.21Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
21.05Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
21.05Single6D27CAY104716D27-DP2-CAY10471
21.05Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
21.05Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
21.05Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
21.05Single6GPSMK08126GPS-CCR2-MK0812
21.05Single6IIVDaltroban6IIV-TP-Daltroban
21.05Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
21.05Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
21.05Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
21.05Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-alpha-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
21.05Consensuscck_offOrthosteric Ligandccka_off
21.05Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
21.05Consensusp2y12_offOrthosteric Ligand4NTJ-P2Y12-AZD1283 7PP1-P2Y12-Selatogrel
21.05Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
21.05Consensusprostanoid_offOrthosteric Ligandep_off tp_off dp_off
21.05Consensustp_offOrthosteric Ligand6IIV-TP-Daltroban 6IIU-TP-Ramatroban
20.83Single4XT1Fractalkine4XT1-US28-Fractalkine
20.83Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
20.83Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
20.83Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.83Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
20.83Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
20.83Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
20.69Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
20.69Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
20.69Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
20.69Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
20.69Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
20.69Consensusgi_class-dOrthosteric Ligandgi_ste
20.69Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
20.69Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
20.69Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
20.59Consensuspth_onOrthosteric Ligandpth1_on pth2_on
20.00Single2HPYAll-trans-retinal2HPY-Rhodopsin-All-trans-retinal
20.00Single4NTJAZD12834NTJ-P2Y12-AZD1283
20.00Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
20.00Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
20.00Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
20.00Single6GPXMK08126GPX-CCR2-MK0812
20.00Single6LMLGlucagon6LML-Glucagon-Glucagon
20.00Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
20.00Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
20.00Single6TQ9SB-4081246TQ9-OX1-SB-408124
20.00Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
20.00Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
20.00Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
20.00Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
20.00Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
20.00Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/&β;1/&γ;2
20.00Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
20.00Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
20.00Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
20.00Single8GDAL9026888GDA-EP4-L902688-Gs/&β;1/&γ;2
20.00Single8GDCPGE28GDC-EP3-PGE2-Gi1/&β;1/&γ;2
20.00Single8IY6Endothelin-18IY6-ETB-Endothelin-1
20.00Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
20.00Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
20.00Consensuscx3cr_onOrthosteric Ligandcx3cr1_on
20.00Consensusep3_onOrthosteric Ligand8GDC-EP3-PGE2-Gi1/&β;1/&γ;2
20.00Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
20.00Consensusep_offOrthosteric Ligandep4_off
20.00Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
19.44Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
19.44Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
19.35Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
19.35Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
19.35Consensusgs_crfOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
19.23Single3OE0CVX153OE0-CXCR4-CVX15
19.23Single6W25SHU91196W25-MC4-SHU9119-Ca
19.23Single7F4DAlpha-MSH7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
19.23Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
19.23Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
19.23Consensuscx3cr1_onOrthosteric Ligand7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
19.23Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
19.23Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.23Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
19.05Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
19.05Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
19.05Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
19.05Single7P2L4YI7P2L-mGlu5-4YI
19.05Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
19.05Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.05Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2
19.05Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
19.05Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.05Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
19.05Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
19.05Consensuschemerin_onOrthosteric Ligandcml1_on
19.05Consensuscml1_onOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
18.75Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
18.75Single3OE6IT1t3OE6-CXCR4-IT1t
18.75Single6LI0GTPL98046LI0-GPR52-GTPL9804
18.75Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
18.75Single8EITDoconexent8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
18.75Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
18.75Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
18.75Consensusglp_onOrthosteric Ligandglp1_on glp2_on
18.52Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
18.52Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
18.52Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
18.52Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
18.52Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
18.52Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
18.52Consensusclass-d_onOrthosteric Ligandste2_on
18.52Consensusgi_class-dOrthosteric Ligandgi_ste
18.52Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
18.52Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
18.52Consensusnmur2_onOrthosteric Ligand7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.52Consensusnmur_onOrthosteric Ligandnmur1_on nmur2_on
18.52Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
18.18Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
18.18Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
18.18Single6IIURamatroban6IIU-TP-Ramatroban
18.18Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
18.18Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
18.18Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
18.18Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
18.18Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
18.18Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
18.18Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
18.18Consensusep_onOrthosteric Ligandep4_on ep2_on ep3_on
18.18Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
18.18Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
17.95Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
17.95Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
17.86Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
17.86Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.86Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
17.86Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
17.86Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
17.86Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
17.86Consensusgs_melanocortinOrthosteric Ligand7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2
17.86Consensusgs_neuromedinOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.86Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
17.65Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
17.65Single5L7IVismodegib5L7I-SMO-Vismodegib
17.65Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
17.65Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
17.65Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/&β;1/&γ;2
17.65Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
17.65Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
17.65Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
17.39Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
17.39Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
17.39Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
17.39Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
17.39Consensusadgrg2_onOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
17.39Consensusc5a1_off_ortoalloOrthosteric Ligand6C1Q-C5a1-PMX53-NDT9513727 6C1R-C5a1-PMX53-Avacopan; Na
17.39Consensuscyslt2_offOrthosteric Ligand6RZ6-CysLT2-ONO-2570366 6RZ9-CysLT2-ONO-2770372 6RZ8-CysLT2-ONO-2080365
17.39Consensuscyslt_offOrthosteric Ligandcyslt2_off
17.24Single4XT3Fractalkine4XT3-US28-Fractalkine
17.24Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
17.24Single6FJ3PTH6FJ3-PTH1-PTH
17.24Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
17.24Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
17.24Single7D3SSecretin7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
17.24Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
17.24Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
17.24Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
17.24Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
17.24Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
17.24Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
17.24Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
17.14Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
17.14Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
16.67Single3ODUIT1t3ODU-CXCR4-IT1t
16.67Single5U09Taranabant5U09-CB1-Taranabant
16.67Single5ZKQABT-4915ZKQ-PAF-ABT-491
16.67Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
16.67Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
16.67Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
16.67Single7BR3Elagolix7BR3-GnRH1-Elagolix
16.67Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
16.67Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
16.67Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
16.67Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
16.67Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
16.67Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
16.67Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
16.67Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
16.67Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
16.67Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
16.67Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
16.67Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
16.67Single8SAI1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
16.67Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
16.67Single8U8FPML8U8F-GPR3-PML-Gs/&β;1/&γ;2
16.67Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
16.67Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
16.67Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
16.67Consensusgs_adgrOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Consensusgs_class-b2Orthosteric Ligandgs_adgr
16.67Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
16.67Consensusp2y_offOrthosteric Ligandp2y1_off p2y12_off
16.67Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
16.67Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
16.13Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
16.13Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
16.13Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
16.13Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
16.13Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
16.13Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
16.13Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
16.00Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
16.00Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
16.00Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
16.00Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
16.00Consensusnmur1_onOrthosteric Ligand7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.00Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
15.79Single6FFIMMPEP6FFI-mGlu5-MMPEP
15.79Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
15.79Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
15.79Single7XOVSR1461317XOV-CCKA-SR146131-Gs/&β;1/&γ;2
15.79Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
15.79Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
15.79Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
15.79Consensusgnrh_offOrthosteric Ligandgnrh1_off
15.79Consensuslh_on_alloOther Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
15.38Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
15.38Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
15.38Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.38Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.38Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
15.00Single4QIMPubChem 249053754QIM-SMO-PubChem 24905375
15.00Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
15.00Single6FFHFenobam6FFH-mGlu5-Fenobam
15.00Single7F83PF-051904577F83-Ghrelin-PF-05190457
15.00Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
15.00Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
15.00Single8EJCTAK-8758EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
15.00Single8EJKTAK-8758EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
15.00Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/&β;1/&γ;2
15.00Consensushcar_offOrthosteric Ligandsuccinate_off
15.00Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
14.81Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
14.81Single7XNACYN1548067XNA-SST2-CYN154806
14.81Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
14.81Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.81Consensusmc5_onOrthosteric Ligand8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
14.81Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
14.71Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
14.71Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Single4PHUFasiglifam4PHU-FFA1 (GPR40)-Fasiglifam
14.29Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
14.29Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
14.29Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
14.29Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
14.29Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
14.29Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
14.29Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
14.29Single8FN1Neurotensin/neuromedin N8FN1-NTS1-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
14.29Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
14.29Consensusccr2_off_alloOther Ligand5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
14.29Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
14.29Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
14.29Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
13.89Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
13.79Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
13.79Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
13.79Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.64Single5TZR-5TZR-FFA1 (GPR40)-MK8666
13.64Single5V56TC1145V56-SMO-TC114
13.64Single7F1TMIP-1a7F1T-CCR5-MIP-1a
13.64Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
13.64Single8GDBPGE28GDB-EP4-PGE2-Gs/&β;1/&γ;2
13.64Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
13.64Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
13.64Consensusmglu2_onOther Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
13.64Consensuss1p2_onOrthosteric Ligand7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
13.33Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
13.33Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
13.33Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
13.33Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
13.33Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/&β;1/&γ;2
13.33Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
13.33Consensusclass-c_onOther Ligandgabab_on mglu_on
13.33Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
13.33Consensusghrh_onOrthosteric Ligand7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
13.16Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
13.04Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
13.04Single4PY02MeSATP4PY0-P2Y12-2MeSATP
13.04Single4XEENeurotensin4XEE-NTS1-Neurotensin
13.04Single4XESNeurotensin4XES-NTS1-Neurotensin
13.04Single5X33BIIL2605X33-BLT1-BIIL260
13.04Single6OS2TRV0266OS2-AT1-TRV026
13.04Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1
13.04Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2
13.04Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/&β;1/γ1
13.04Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
13.04Single8IBUErythromycin A8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.04Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
13.04Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
13.04Consensuschemokine_offOrthosteric Ligandcxcr_off
13.04Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II
13.04Consensuscxcr_offOrthosteric Ligandcxcr4_off
12.90Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
12.90Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
12.90Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
12.82Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
12.50Single4BUONeurotensin4BUO-NTS1-Neurotensin
12.50Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
12.50Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2
12.50Single7VDMSubstance P7VDM-MRGPRX2-Substance P-Gi1/&β;1/&γ;2
12.50Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
12.50Single7XKDBetahydroxyandrosterone7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
12.50Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/&β;1/&γ;2
12.50Consensusep2_onOrthosteric Ligand7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
12.50Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
12.50Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
12.12Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
12.12Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
12.12Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
12.00Consensusmotilin_onOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.76Single3OE8IT1t3OE8-CXCR4-IT1t
11.76Single7S8O(R)-Zinc-35737S8O-MRGPRX2-(R)-Zinc-3573-Gi1/&β;1/&γ;2
11.76Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
11.76Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
11.76Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
11.76Consensusgip_on_alloOther Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
11.76Consensussmo_off_alloOrthosteric Ligand6D32-SMO-Cyclopamine-Cyclopamine
11.54Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
11.54Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
11.54Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/&β;1/&γ;1
11.54Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
11.43Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
11.11Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
11.11Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
11.11Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
11.11Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
11.11Single7S8N(R)-Zinc-35737S8N-MRGPRX2-(R)-Zinc-3573-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.11Single7SK5CXCL127SK5-ACKR3-CXCL12
11.11Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
11.11Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
11.11Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
11.11Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
11.11Single8X2K5YM8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
11.11Consensusclass-t_onOrthosteric Ligandtaste2_on
11.11Consensusgo_adhesionOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
11.11Consensusgo_class-b2Orthosteric Ligandgo_adhesion
11.11Consensusgs_class-tOrthosteric Ligandgs_taste
11.11Consensusgs_tasteOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
11.11Consensussmo_on_alloOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
11.11Consensussst_offOrthosteric Ligandsst2_off
11.11Consensustaste2_onOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
10.71Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
10.71Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.71Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
10.71Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
10.53Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
10.53Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
10.53Single7F8YDevazepide7F8Y-CCKA-Devazepide
10.53Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
10.53Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
10.53Single8FN0Neurotensin/neuromedin N8FN0-NTS1-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
10.53Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
10.53Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
10.53Consensusm2_on_alloOther Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
10.53Consensussmo_on_alloOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
10.34Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
10.00Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
10.00Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
10.00Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.00Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
10.00Single7VV6C48/807VV6-MRGPRX2-C48/80
10.00Single7VVOPTH7VVO-PTH1-PTH-Gs/&β;1/&γ;2
10.00Single8K2WAMG4878K2W-CXCR3-AMG487
10.00Single8T3VDHA8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.00Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
10.00Consensuscxcr_onOrthosteric Ligandcxcr1_on cxcr2_on
10.00Consensusm1_off_alloOther Ligand6WJC-M1-Atropine-Muscarinic toxin 7
9.68Single7SK3CXCL127SK3-ACKR3-CXCL12
9.52Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
9.52Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
9.52Consensusffa1_onOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.52Consensussmo_offOrthosteric Ligand5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
9.38Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
9.38Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
9.09Single4JKVTaladegib (LY2940680)4JKV-SMO-Taladegib (LY2940680)
9.09Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
9.09Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
9.09Single8JPCNeurotensin 8-138JPC-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
9.09Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
9.09Consensuscalcitonin_onOrthosteric Ligandct_on ctlike_on
8.70Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
8.70Single4BV0Neurotensin4BV0-NTS1-Neurotensin
8.70Single5V57TC1145V57-SMO-TC114
8.70Single6OS1TRV0266OS1-AT1-TRV026
8.70Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
8.70Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
8.70Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2
8.70Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1
8.70Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/&β;1/&γ;1
8.70Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.70Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.70Single8FMZNeurotensin/neuromedin N8FMZ-NTS1-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.70Consensusnts1_on_alloOrthosteric Ligand8JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
8.33Single4GRVNeurotensin 8-134GRV-NTS1-Neurotensin 8-13
8.33Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/&β;1/&γ;2
8.33Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
8.33Single6YVRNTS8-136YVR-NTS1-NTS8-13
8.33Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/&β;1/&γ;2
8.33Single8JPBNeurotensin 8-138JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
8.33Consensusclass-c_offOther Ligandgabab_off mglu_off
8.33Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
8.33Consensusnts1_offOrthosteric Ligand6Z4Q-NTS1-SR142948A 6Z4S-NTS1-SR48692
8.33Consensusnts1_onOrthosteric Ligand6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
8.33Consensusnts_offOrthosteric Ligandnts1_off
8.33Consensusnts_onOrthosteric Ligandnts1_on
8.00Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/&β;1/&γ;2
8.00Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
8.00Single7CX2PGE27CX2-EP2-PGE2-Gs/&β;1/&γ;2
8.00Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
8.00Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.00Consensusgi_neurotensinOrthosteric Ligand7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
8.00Consensusgs_galaninOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.69Single6KNMJN241-96KNM-Apelin-JN241-9
7.69Single8INRAlpha-MSH8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
7.69Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
7.41Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
7.14Single7SHEPI; PE7SHE-GPR158-PI; PE
7.14Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.14Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
6.67Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
6.67Consensusccr8_offOrthosteric Ligand8TLM-CCR8-Anti-murine CCR8 antibody
6.25Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
6.25Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
5.88Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
5.88Single7Y14Beta-alanine7Y14-MRGPRD-Beta-alanine
5.88Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/&β;1/&γ;2
5.56Single4XNWMRS25004XNW-P2Y1-MRS2500
5.56Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
5.56Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
5.56Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2
5.56Single7Y12Beta-alanine7Y12-MRGPRD-Beta-alanine-Gi1/&β;1/&γ;2
5.56Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/&β;1/&γ;2
5.56Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
5.26Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
5.26Single4O9RCyclopamine4O9R-SMO-Cyclopamine
5.26Single7XKFBetahydroxyandrosterone7XKF-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
5.26Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
5.26Consensusgo_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
5.26Consensusgo_proteinOrthosteric Ligandgo_chemokine
5.26Consensusm4_on_alloOther Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
5.00Single4BWBNeurotensin4BWB-NTS1-Neurotensin
5.00Single4QINSAG1.54QIN-SMO-SAG1.5
5.00Single4XNVBPTU4XNV-P2Y1-BPTU
5.00Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
5.00Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
5.00Single6WWZCCL206WWZ-CCR6-CCL20-Go/&β;1/&γ;2
5.00Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
5.00Single7WV9ZCZ0117WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
5.00Single8DWHCompound-168DWH-MRGPRX1-Compound-16-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.00Consensuscb1_on_alloOther Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
5.00Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
5.00Consensusclass-f_offOrthosteric Ligandsmo_off
4.76Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
4.76Single6ZINSR486926ZIN-NTS1-SR48692
4.76Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
4.76Single7XJJGalanin7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
4.76Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
4.76Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76Single8IYXYL-3658IYX-GPR34-YL-365
4.76Single8JD6N-(3-chlorophenyl)pyridine-2-carboxamide8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
4.76Consensusgi_class-fOrthosteric Ligandgi_frizzled
4.76Consensusgi_frizzledOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
4.76Consensusgo_galaninOrthosteric Ligand7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
4.65Consensusgs_ctOrthosteric Ligand7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
4.55Single5T04Neurotensin5T04-NTS1-Neurotensin
4.55Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
4.55Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
4.55Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
4.55Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
4.55Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
4.55Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/&β;1/&γ;2
4.55Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
4.55Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
4.35Single6Z4SSR486926Z4S-NTS1-SR48692
4.17Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
4.17Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
4.00Single7SHEPI; PE7SHE-GPR158-PI; PE
4.00Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.00Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.00Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.00Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.85Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
3.57Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
3.45Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
2.86Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
2.78Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
2.78Single7TYIAmylin7TYI-CT-Amylin-Gs/&β;1/&γ;2
2.78Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
2.70Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
2.63Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
2.63Single8F0KPramlintide analogue san3858F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.56Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
2.56Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
2.44Single8F2APramlintide analogue san3858F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.33Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
2.27Single8F2BPramlintide analogue san458F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
2.17Single8F0JPramlintide analogue san458F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2

Consensus Members
Id Members
beta_off beta1_off
beta2_off
alpha_off alpha1_off
alpha2_off
Net Summary
Imin 3.6525
Number of Linked Nodes 275
Number of Links 296
Number of Hubs 30
Number of Links mediated by Hubs 136
Number of Communities 4
Number of Nodes involved in Communities 33
Number of Links involved in Communities 46
Path Summary
Number Of Nodes in MetaPath 50
Number Of Links MetaPath 49
Number of Shortest Paths 76262
Length Of Smallest Path 3
Average Path Length 13.891
Length of Longest Path 29
Minimum Path Strength 0.602679
Average Path Strength 5.90299
Maximum Path Strength 18.4777
Minimum Path Correlation 0.703214
Average Path Correlation 0.91332
Maximum Path Correlation 0.988125
Minimum % Of Corr. Nodes 3.7037
Average % Of Corr. Nodes 44.3252
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 36.5726
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following differences:
Id1st Network2nd Network
adrenergic_off_onadrenergic_offadrenergic_on
This network is also present in following consensuses:
IdComponents
amine_offadrenergic_off
histamine_off
muscarinic_off
5ht_off
dopamine_off



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Download adrenergic_off.zip



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