Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
1G.HN.43 2.43408
2G.S1.02 3.83167694
3G.S2.08 4.288595
4G.S3.01 3.5525494
5G.S3.06 7.052516
6G.H2.06 3.94519
7G.H2.07 4.77419
8G.H2.09 6.625408
9G.h2s4.01 4.34519
10G.S4.04 4.208577239
11G.H3.09 7.0825409
12G.H3.18 4.035229
13G.S5.04 3.538509
14G.S5.05 3.427147189
15G.s5hg.01 3.33254249
16G.HG.04 6.065408
17G.hgh4.01 3.9254134
18G.hgh4.02 4.3085138
19G.H4.15 5.4375408
20G.S6.02 5.821676148
21G.s6h5.01 4.64254189
22G.H5.05 3.895495
23G.H5.14 3.9054146
24G.H5.25 3.31754256
25G.H5.26 4.8075405
26b.1x4 3.13408
27b.1x11 2.73754268
28b.lhb1x6 2.3825403
29b.b1x3 6.34487
30b.l1x3 6.075717119
31b.b2x5 6.494507
32b.l3x2 4.7565119
33b.b4x6 6.985717119
34b.b4x7 7.114218
35b.l4x2 7.3375484
36b.b5x3 4.8725409
37b.b5x5 4.2154175
38b.l5x5 4.76857719
39b.b6x5 3.754506
40b.b7x1 3.105634
41b.l7x2 4.225419
42b.l7x4 4.6325409
43b.b8x4 3.4075406
44b.l8x1 2.8454175
45b.l8x5 3.34433
46b.l9x6 3.7721018
47b.b10x4 4.73254276
48b.b10x5 3.31286739
49b.l10x1 2.735403
50b.l11x1 4.5175419
51b.b12x6 5.92638
52b.b13x7 6.0645107
53b.l13x3 5.3825109
54b.l13x6 5.5625419
55b.b15x1 56109
56b.b15x3 3.55254109
57b.l15x2 4.6575409
58b.b16x5 3.7575405
59b.b16x6 7.296108
60b.b17x7 6.1425448
61b.l17x3 4.55749
62b.b18x3 3.2425448
63b.l18x1 4.751676166
64b.l18x2 5.30754167
65b.b19x2 5.19546
66b.b19x4 4.296548
67b.l19x2 5.35549
68b.b20x2 3.5446
69b.b20x4 6.99833648
70b.b20x6 6.58546
71b.b21x3 6.935446
72b.b21x5 5.2675464
73b.b21x7 4.98667665
74b.b22x5 4.81254167
75b.l22x5 5.2125159
76b.b23x6 5.57833667
77b.l23x1 5.7675406
78b.b24x4 5.87566
79b.b24x6 6.265468
80b.b24x7 5.8045159
81b.l24x3 6.754155
82b.b25x3 6.8465
83b.b25x6 3.2875463
84b.l25x3 10.0225479
85b.l25x5 3.5925477
86b.l26x1 5.6754287
87b.l27x1 10.214579
88b.l27x2 5.33579
89b.b28x4 7.0625476
90b.b28x6 5.98579
91g.h2x11 8.07754166
92g.ctx3 6.456509
93g.ctx15 5.025489
94g.ctx16 3.73333688
95Lig 33.6482020
961x35 5.242505
971x39 4.6225408
98I1x51 3.2925407
992x42 3.54167607
1002x51 2.54407
1012x53 4.4985296
102E1x50 5.091258128
103E1x52 4.68754127
1043x24 3.36754125
1053x50 5.03409
106I2x55 3.9575405
107I2.R159 5.625405
1084x53 2.65754307
1094x64 6.33254204
110E2.Y189 8.485422
111E2.K200 7.84425
112E2.Y201 7.1845206
1135x40 2.2525405
1145x47 5.914558
1155x57 2.6925407
1165x58 4.72833609
1176x48 5.165459
118E3.R286 7.18423
1197x42 4.48254297
1207x45 6.53559
1217x49 5.8725459
1227x53 4.15559
1237x55 2.4554196
1248x50 5.5985198
1258x57 4.8025405
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1b.b2x3 b.b2x5 29.4852.33NoYes067
2b.b26x2 b.b2x3 29.92443.24NoNo076
3b.b26x1 b.b26x2 30.02345.16NoNo097
4b.b26x1 b.l27x1 30.25444.94NoYes099
5G.H2.09 b.l27x1 83.19372.12YesYes089
6G.H2.09 b.b6x1 79.68413.94YesNo089
7b.b6x1 b.l9x6 77.65082.39NoYes198
8G.H2.07 b.l9x6 85.88131.93YesYes198
9G.H2.04 G.H2.07 87.1462NoYes099
10G.H2.04 G.H3.08 87.2488.34NoNo099
11G.H3.08 G.S4.04 87.35613.58NoYes099
12G.H3.05 G.S4.04 93.22452.64NoYes2399
13G.H3.05 G.s1h1.02 99.28511.71NoNo097
14G.s1h1.02 G.s1h1.05 99.35811.71NoNo079
15G.S4.07 G.s1h1.05 99.430810.31NoNo089
16G.S4.07 G.s5hg.01 99.71812.77NoYes089
17G.s1h1.06 G.s5hg.01 99.931.74NoYes099
18G.S5.07 G.s1h1.06 1001.7NoNo099
19G.H1.04 G.S5.07 49.98568.5NoNo079
20G.H1.04 G.S5.05 49.95533.77NoYes079
21G.S5.03 G.S5.05 99.13713.77NoYes089
22G.S4.01 G.S5.03 97.48551.62NoNo088
23G.S1.04 G.S4.01 97.48431.58NoNo078
24G.S1.02 G.S1.04 95.30622.98YesNo047
25G.H5.11 G.S1.02 94.83981.6NoYes084
26G.H5.11 G.H5.15 94.70711.54NoNo088
27G.H5.15 I2x50 94.5741.62NoNo088
28G.H5.19 I2x50 94.17281.56NoNo088
293x53 G.H5.19 94.03841.56NoNo088
303x53 I2.R159 93.63324.15NoYes085
313x49 I2.R159 92.52858.34NoYes085
322x42 3x49 92.39073.45YesNo078
33G.S5.07 G.s6h5.01 50.08525.85NoYes099
34G.S5.05 G.s6h5.01 49.95475.19YesYes1899
35b.l11x1 b.l9x6 14.16045.79YesYes198
363x46 3x50 27.76173.76NoYes099
372x42 3x46 61.44353.63YesNo079
383x50 7x53 13.76834.12YesYes099
393x50 5x58 11.30616.17YesYes099
40b.b17x5 b.b17x7 11.2378.2NoYes078
41b.l2x5 b.l4x2 10.39620.58NoYes054
42b.b2x5 b.l4x1 13.68414.94YesNo075
43b.l4x1 b.l4x2 13.45042.54NoYes054
44b.b11x6 b.l11x1 13.93393.71NoYes099
45b.b11x6 b.l9x3 12.915213.95NoNo099
46b.b12x6 b.l9x3 10.54972.12YesNo389
47b.b15x4 b.l17x7 10.28781.76NoNo067
48b.l17x3 b.l17x7 10.52083.98YesNo097
49b.b19x4 b.l17x3 14.85465.48YesYes489
50b.l17x3 b.l19x2 28.53722.52YesYes499
51b.l25x6 b.l27x1 49.339513.99NoYes789
52b.l23x1 b.l25x6 49.527110.72YesNo068
53b.l21x8 b.l23x1 34.73021.68NoYes046
54b.l19x1 b.l21x8 34.50021.68NoNo094
55b.l17x5 b.l19x1 34.05212.94NoNo069
56b.l21x7 b.l23x1 14.53057.78NoYes056
57b.l21x7 b.l23x2 14.27336.22NoNo058
58b.b23x6 b.l23x2 12.44273.45YesNo078
592x46 3x46 34.87682.92NoNo099
602x46 3x42 26.50782.83NoNo097
613x42 4x49 50.74322.98NoNo076
623x38 4x49 49.88231.71NoNo076
633x38 4x53 49.00183.44NoYes3077
643x34 4x53 48.15653.1NoYes057
653x34 4x57 46.85877.74NoNo056
663x33 4x57 42.51053.42NoNo056
673x33 4x61 42.07395.03NoNo054
684x61 4x65 41.63694.39NoNo045
694x65 E2x52 22.97916.52NoNo055
70E2x51 E2x52 18.903811NoNo035
71E2.Y189 E2x51 18.44934.49YesNo023
72E2.Y189 Lig 15.222612.35YesYes220
732x42 4x46 31.10922.69YesNo077
742x45 4x46 25.2964.72NoNo097
752x45 3x42 25.10792.75NoNo097
762x60 3x32 10.677613.5NoNo067
772x60 E1x50 11.13783.75NoYes068
78E1x50 E2x50 17.53910.45YesNo1289
793x29 E2x50 18.45543.23NoNo059
803x29 4x65 18.909912.59NoNo055
813x43 7x49 10.44956.87NoYes589
822x46 3x43 11.0552.83NoNo098
835x47 6x48 16.6242.34YesYes589
846x48 7x45 12.17098.65YesYes599
857x45 7x49 13.58846.38YesYes599
86b.l17x5 b.l19x2 33.83115.89NoYes069
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
7x34Lig3.060NoYes5010
E2.T191Lig3.892NoYes3010
E2.Q192Lig11.212NoYes2010
E2.V196Lig2.622NoYes3010
LigNT.L3514.32YesNo0401
LigNT.M3315.772YesNo0101
E3.R286Lig14.412YesYes3010
6x65Lig4.790NoYes1010
LigNT.V292.922YesNo0301
LigNT.E326.52YesNo0201
LigNT.Y276.192YesNo0601
E2.Y189Lig12.352YesYes2010
E2.K200Lig10.82YesYes5010
NT.S28NT.Y277.630NoNo3621
NT.E32NT.V295.72NoNo2311
7x24NT.C365.462NoNo7511
1x28E2.Q1922.340NoNo4221
E2.K200E2.Q1875.422YesNo5412
E2.Q187E2.Q2026.42NoNo4522
E2.T191E2.Y1898.742NoYes3211
E2.Y189E2x514.492YesNo2312
E2.K200E2.Y1898.362YesYes5211
E2.T191E2.V1963.172NoNo3311
E2.K200E2.Q2026.782YesNo5512
6x616x644.22NoNo4122
6x61E3.R2863.622NoYes4321
6x64E3.R2863.712NoYes1321
7x27E3.R2866.980NoYes4321
7x31Lig1.70NoYes5010
6x63Lig1.680NoYes2010
5x32Lig1.632NoYes2010
LigNT.C361.592YesNo0501
7x24Lig1.592NoYes7010
NT.C36NT.L381.592NoNo5312
5x32E2.E2061.572NoNo2312

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
100.00Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
46.15Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
45.45Single4XNWMRS25004XNW-P2Y1-MRS2500
45.45Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
41.67Single9E7RGB889E7R-PAR2-GB88-chim(NtGi1L-Gs-CtGq)/β1/γ2
40.00Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
40.00Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
38.89Single8XQJJN2418XQJ-Apelin-JN241
38.46Single4BWBNeurotensin4BWB-NTS1-Neurotensin
37.50Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
36.36Consensusp2y_offOrthosteric Ligandp2y1_off
35.29Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
35.29Single4XEENeurotensin4XEE-NTS1-Neurotensin
35.29Single4XESNeurotensin4XES-NTS1-Neurotensin
35.29Single6YVRNTS8-136YVR-NTS1-NTS8-13
35.29Single8XQJJN2418XQJ-Apelin-JN241
33.33Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
33.33Single8JPFNeurotensin8JPF-NTS1-Neurotensin-SBI-553
33.33Single8XVUCXCL28XVU-CXCR2-CXCL2
33.33Single8XWFCXCL38XWF-CXCR2-CXCL3
33.33Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
33.33Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
31.58Single6KNMJN241-96KNM-Apelin-JN241-9
31.58Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
30.43Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
30.00Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
30.00Single8XWNCXCL88XWN-CXCR2-CXCL8
30.00Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
30.00Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
30.00Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
29.41Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
29.41Single4BV0Neurotensin4BV0-NTS1-Neurotensin
29.41Single7F1TMIP-1a7F1T-CCR5-MIP-1a
29.41Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
29.41Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
29.41Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
29.41Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
29.41Consensusneurotensin_onOrthosteric Ligandnts1_on
29.41Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
28.57Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
28.57Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
28.57Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
28.57Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
28.57Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
27.78Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
27.78Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
27.78Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
27.78Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
27.78Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
27.78Single8XWACXCL18XWA-CXCR2-CXCL1
27.78Single8XWMCXCL68XWM-CXCR2-CXCL6
27.78Single8XWSCXCL58XWS-CXCR2-CXCL5
27.78Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
27.78Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
27.78Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
27.78Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
27.78Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
27.27Single7V68LY21196207V68-M4-Iperoxo-LY2119620-Gi1/β1/γ2
27.27Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
26.67Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
26.67Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
26.67Single5UVIZM-2413855UVI-A2A-ZM-241385
26.67Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
26.67Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
26.67Single7T94LY21196207T94-M2-Acetylcholine-LY2119620-chim(NtGi1-Go)/β1/γ2
26.67Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
26.67Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
26.67Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
26.67Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
26.32Single4BUONeurotensin4BUO-NTS1-Neurotensin
26.32Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
26.32Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
25.93Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
25.00Single3EMLZM-2413853EML-A2A-ZM-241385
25.00Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
25.00Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
25.00Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
25.00Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
25.00Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
25.00Single6S0LZM-2413856S0L-A2A-ZM-241385
25.00Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
25.00Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
25.00Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
25.00Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
25.00Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
25.00Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
25.00Single8TH3AT118-H Nanobody8TH3-AT1-AT118-H Nanobody
25.00Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
25.00Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
25.00Single9IMATalquetamab9IMA-GPRC5D-Talquetamab
25.00Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
25.00Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
25.00Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
25.00Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
25.00Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
25.00Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
25.00Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
24.00Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
24.00Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
24.00Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
24.00Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
24.00Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
23.81Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
23.81Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
23.81Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
23.53Single5IUAQ274563485IUA-A2A-Q27456348-Na
23.53Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
23.53Single6S0QZM-2413856S0Q-A2A-ZM-241385
23.53Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
23.53Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
23.53Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
23.53Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
23.53Single8ZYTNeurotensin peptide 8-138ZYT-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
23.08Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
23.08Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/β1/γ2
23.08Single8JPSCCL78JPS-ACKR1-CCL7
22.73Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
22.73Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
22.73Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
22.73Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
22.73Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
22.73Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
22.22Single5V57TC1145V57-SMO-TC114
22.22Single6OS1TRV0266OS1-AT1-TRV026
22.22Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
22.22Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.22Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.22Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
22.22Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
22.22Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
22.22Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
21.74Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
21.74Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
21.74Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
21.74Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Single4O9RCyclopamine4O9R-SMO-Cyclopamine
21.43Single6IGKEndothelin-36IGK-ETB-Endothelin-3
21.43Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
21.43Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
21.43Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
21.43Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
21.05Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
21.05Single6OS2TRV0266OS2-AT1-TRV026
21.05Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
21.05Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
21.05Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.05Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
21.05Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
21.05Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
21.05Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
21.05Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
21.05Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
21.05Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
21.05Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
21.05Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
20.83Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
20.83Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
20.83Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
20.83Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
20.00Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
20.00Single4QINSAG1.54QIN-SMO-SAG1.5
20.00Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
20.00Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
20.00Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
20.00Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
20.00Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
20.00Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
20.00Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
20.00Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
20.00Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
20.00Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
20.00Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
20.00Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
20.00Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-SBI-553-chim(NtGi1-Go)/β1/γ2
20.00Single8GNGIstradefylline8GNG-A2A-Istradefylline
20.00Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
20.00Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
20.00Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
20.00Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
20.00Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
20.00Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
20.00Single8YYWAlpha-ketoglutarate8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
20.00Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
20.00Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
20.00Single9JFYhNPSF9JFY-NPFF2-hNPSF-Gi1/β1/γ2
20.00Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
20.00Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
20.00Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
20.00Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
20.00Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
20.00Consensuspac_onOrthosteric Ligandpac1_on
19.23Single7SK3CXCL127SK3-ACKR3-CXCL12
19.23Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
19.23Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
19.23Consensuspac_on_gpOrthosteric Ligandpac1_on_gp
19.05Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
19.05Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
19.05Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
19.05Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
19.05Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
19.05Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
19.05Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
19.05Single8QJ2pN1628QJ2-MC4-pN162-Gs
19.05Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
18.75Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
18.75Single5IU7Q274563465IU7-A2A-Q27456346-Na
18.75Single5IUBQ274563445IUB-A2A-Q27456344-Na
18.75Single5JTBZM-2413855JTB-A2A-ZM-241385
18.75Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
18.75Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
18.75Single6MH8ZM-2413856MH8-A2A-ZM-241385
18.75Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
18.75Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
18.75Single7AROLUF58337ARO-A2A-LUF5833-Na
18.75Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
18.75Single7T32ZM-2413857T32-A2A-ZM-241385
18.75Single7UTZDPPC7UTZ-TSH-TR1402-DPPC-Gs/β1/γ2
18.75Single7VV6C48/807VV6-MRGPRX2-C48/80
18.75Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
18.75Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
18.75Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
18.75Single9K0KUTP9K0K-P2Y4-UTP-chim(NtGi1-Gs-CtGq)/β1/γ2
18.75Single9K0XATP9K0X-P2Y2-ATP-chim(NtGi1-Gs-CtGq)/β1/γ2
18.75Single9K20ATP9K20-P2Y2-ATP-chim(NtGi1-Go)/β1/γ2
18.75Consensusa2_offOrthosteric Liganda2a_off
18.75Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
18.75Consensusgrh_offOrthosteric Ligandgnrh1_off
18.75Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
18.52Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
18.52Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
18.52Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
18.52Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
18.52Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
18.52Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
18.18Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
18.18Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
18.18Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
18.18Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
18.18Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
18.18Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
18.18Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
17.86Single6IGLIRL16206IGL-ETB-IRL1620
17.86Single8IY6Endothelin-18IY6-ETB-Endothelin-1
17.86Consensusendothelin_onOrthosteric Ligandetb_on eta_on
17.65Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
17.65Single5IU8Q274563475IU8-A2A-Q27456347-Na
17.65Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
17.65Single5T04Neurotensin5T04-NTS1-Neurotensin
17.65Single6D27CAY104716D27-DP2-CAY10471
17.65Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
17.65Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
17.65Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
17.65Single7PYRPSB-21157PYR-A2A-PSB-2115
17.65Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
17.65Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
17.65Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
17.65Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
17.65Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
17.65Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
17.65Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
17.39Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
17.39Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
17.39Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
17.39Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
17.39Single7SK5CXCL127SK5-ACKR3-CXCL12
17.39Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
17.39Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
17.39Single7XNACYN1548067XNA-SST2-CYN154806
17.39Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
17.39Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
17.39Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
17.39Single9IQRMuscarinic toxin 39IQR-α2a-Muscarinic toxin 3
17.39Single9IQSMuscarinic toxin 39IQS-M4-Muscarinic toxin 3
17.39Single9IQVMuscarinic toxin 39IQV-Alpha1A-Muscarinic toxin 3
17.39Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
17.39Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
17.39Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
17.39Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
17.39Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
17.39Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
17.39Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
17.39Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
17.24Single5GLHEndothelin-15GLH-ETB-Endothelin-1
17.24Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
17.24Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
17.24Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
16.67Single3OE0CVX153OE0-CXCR4-CVX15
16.67Single4JKVTaladegib4JKV-SMO-Taladegib
16.67Single5N2RPSB-365N2R-A2A-PSB-36-Na
16.67Single5N2SPSB365N2S-A1-PSB36
16.67Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
16.67Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
16.67Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
16.67Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
16.67Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
16.67Single7XKDBeta-Hydroxyandrosterone7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
16.67Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
16.67Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
16.67Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
16.67Single8GNEKW-63568GNE-A2A-KW-6356-Na
16.67Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
16.67Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
16.67Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
16.67Single8QOTNanobody-E8QOT-μ-Nanobody-E
16.67Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
16.67Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
16.67Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
16.67Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
16.67Single9U4WGonadoliberin-19U4W-GnRH1-Gonadoliberin-1-chim(NtGi1L-Gs-CtGq)/β1/γ2
16.67Consensusadenosine_offOrthosteric Liganda1_off a2_off
16.67Consensusangiotensin_onOrthosteric Ligandat1_on
16.67Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
16.67Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
16.67Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
16.67Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
16.67Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
16.67Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
16.67Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
16.67Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
16.00Single6JODAngiotensin II6JOD-AT2-Angiotensin II
16.00Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
16.00Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
16.00Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
16.00Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
16.00Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
16.00Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
16.00Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
16.00Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
16.00Single8ZBISomatostatin-148ZBI-SST3-Somatostatin-14-Gi1/β1/γ2
16.00Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
16.00Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
16.00Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
16.00Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
16.00Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
16.00Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
16.00Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
16.00Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
15.79Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
15.79Single5V56TC1145V56-SMO-TC114
15.79Single7PX4PSB-21137PX4-A2A-PSB-2113
15.79Single7T9NDPPC7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
15.79Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
15.79Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
15.79Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
15.79Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
15.79Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
15.79Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
15.79Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
15.79Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
15.79Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
15.79Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
15.79Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
15.79Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
15.79Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
15.79Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
15.79Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
15.79Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
15.79Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
15.79Consensuslpa_onOrthosteric Ligandlpa1_on
15.79Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
15.79Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
15.62Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
15.38Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
15.38Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
15.38Single6XBM5LWE6XBM-SMO-5LWE-Gi1/β1/γ2
15.38Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
15.38Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
15.38Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
15.38Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
15.38Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
15.38Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
15.38Single8A2OTheophylline8A2O-A2A-Theophylline-Na
15.38Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
15.38Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
15.38Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.38Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
15.38Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
15.38Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Gi1/β1/γ2
15.38Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
15.38Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
15.38Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
15.38Single8ZRTET-18ZRT-ETB-ET-1
15.38Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
15.38Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
15.38Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
15.38Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
15.00Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
15.00Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
15.00Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
15.00Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
15.00Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
15.00Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.00Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
15.00Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
15.00Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
15.00Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
15.00Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
15.00Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
15.00Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
15.00Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
15.00Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
15.00Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
15.00Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
15.00Consensuslpa_offOrthosteric Ligandlpa1_off
15.00Consensuslpl_offOrthosteric Ligands1p_off lpa_off
15.00Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
15.00Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
14.81Single4XT3Fractalkine4XT3-US28-Fractalkine
14.81Single6FJ3PTH6FJ3-PTH1-PTH
14.81Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
14.81Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
14.81Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
14.81Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
14.81Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
14.81Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
14.81Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
14.81Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
14.81Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
14.81Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
14.81Single9KFKRelaxin-39KFK-RXFP4-Relaxin-3-Gi2/β1/γ2
14.81Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
14.81Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
14.81Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
14.81Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
14.81Consensuspac1_onOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
14.81Consensuspac1_on_gpOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
14.81Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
14.71Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
14.71Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
14.29Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
14.29Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
14.29Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
14.29Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
14.29Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
14.29Single7EZCUKA7EZC-A2A-UKA
14.29Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
14.29Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
14.29Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
14.29Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
14.29Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
14.29Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
14.29Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
14.29Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
14.29Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
14.29Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
14.29Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
14.29Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
14.29Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
14.29Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
14.29Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
14.29Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
14.29Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
14.29Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
14.29Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
14.29Single8ZPLHF511168ZPL-CXCR4-HF51116
14.29Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
14.29Consensuscck_onOrthosteric Ligandccka_on cckb_on
14.29Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
14.29Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
14.29Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
14.29Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
13.79Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
13.79Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
13.79Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
13.79Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
13.79Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
13.79Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
13.79Single9BYOExendin-39BYO-GLP-1-Exendin-3-Gs/β1/γ2
13.79Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
13.79Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
13.79Consensusbradykinin_onOrthosteric Ligandbk2_on
13.79Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
13.79Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
13.79Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
13.79Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
13.79Consensuspth1_onOrthosteric Ligand6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
13.79Consensusvip-pacap_onOrthosteric Ligandvpac_on pac_on
13.79Consensusvip-pacap_on_gpOrthosteric Ligandvpac_on_gp pac_on_gp
13.64Single4UG2CGS216804UG2-A2A-CGS21680
13.64Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
13.64Single5WF6UK-4320975WF6-A2A-UK-432097
13.64Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
13.64Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
13.64Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
13.64Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
13.64Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
13.64Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
13.64Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
13.64Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
13.64Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
13.64Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
13.64Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
13.64Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
13.64Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
13.64Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
13.64Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
13.64Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
13.64Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
13.64Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
13.64Consensuskisspeptin_onOrthosteric Ligandkiss1_on
13.64Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
13.64Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
13.64Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
13.64Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
13.64Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
13.33Single5L7IVismodegib5L7I-SMO-Vismodegib
13.33Single6LI0C176LI0-GPR52-C17
13.33Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
13.33Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
13.33Single7UL2SR486927UL2-NTS1-SR48692-Na
13.33Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
13.33Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab
13.33Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
13.33Single8ZYUNeurotensin peptide 8-138ZYU-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
13.33Single9B9Y7DY9B9Y-CB1-7DY
13.33Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
13.33Consensusclass-a_class-b1_cons_onOrthosteric Ligandclass-a_on class-b1_on
13.33Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
13.33Consensusgq_nucleotideOrthosteric Ligandgq_p2y
13.33Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
13.33Consensusneurotensin_offOrthosteric Ligandnts1_off
13.33Consensusnts1_offOrthosteric Ligand7UL2-NTS1-SR48692-Na
13.04Single4XT1Fractalkine4XT1-US28-Fractalkine
13.04Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
13.04Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
13.04Single7F8XNN90567F8X-CCKA-NN9056
13.04Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
13.04Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
13.04Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
13.04Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
13.04Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.04Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
13.04Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
13.04Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
13.04Single8U4OCXCL128U4O-CXCR4-CXCL12-Gi1/β1/γ2
13.04Single8WDTphotoNECA8WDT-A2A-photoNECA
13.04Single8YWFRetatrutide8YWF-GLP-1-Retatrutide-chim(NtGi1-Gs)/β1/γ2
13.04Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
13.04Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
13.04Single9BUYLM1899BUY-β2-LM189-Gi1/β1/γ2
13.04Single9J0IUDP-Glucuronic acid9J0I-P2Y14-UDP-Glucuronic acid-Gi1/β1/γ2
13.04Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
13.04Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
13.04Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
13.04Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
13.04Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
13.04Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
13.04Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
13.04Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
13.04Consensuslpl_onOrthosteric Ligands1p_on lpa_on
13.04Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
13.04Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
13.04Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
13.04Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
13.04Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
13.04Consensussomatostatin_offOrthosteric Ligandsst2_off
12.90Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
12.90Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
12.90Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
12.90Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
12.90Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
12.90Consensusglp1_onOrthosteric Ligand7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
12.90Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
12.90Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
12.50Single3PWHZM-2413853PWH-A2A-ZM-241385
12.50Single3QAKUK-4320973QAK-A2A-UK-432097
12.50Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
12.50Single5U09Taranabant5U09-CB1-Taranabant
12.50Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
12.50Single7BR3Elagolix7BR3-GnRH1-Elagolix
12.50Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
12.50Single7F8ULintitript7F8U-CCKA-Lintitript
12.50Single7F8YDevazepide7F8Y-CCKA-Devazepide
12.50Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
12.50Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
12.50Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
12.50Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
12.50Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
12.50Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
12.50Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
12.50Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
12.50Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
12.50Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
12.50Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
12.50Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
12.50Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
12.50Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
12.50Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
12.50Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
12.50Single8U4PAMD31008U4P-CXCR4-AMD3100-Gi1/β1/γ2
12.50Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
12.50Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
12.50Single8YYWAlpha-ketoglutarate8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
12.50Single9E82SDF-1-beta9E82-ACKR3-SDF-1-β-Arrestin2
12.50Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
12.50Single9IK8SST analogue9IK8-SST1-SST analogue-Gi1/β1/γ2
12.50Single9J0FNADH9J0F-P2Y14-NADH-Gi1/β1/γ2
12.50Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
12.50Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
12.50Single9KFIRelaxin-39KFI-RXFP3-Relaxin-3-Gi2/β1/γ2
12.50Consensusglp1_on_gpOrthosteric Ligand7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
12.50Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
12.50Consensuspth1_on_gpOrthosteric Ligand6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
12.12Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
12.12Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
12.12Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
12.12Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
12.12Consensusclass-a_class-b1_cons_on_gpOrthosteric Ligandclass-a_on_gp class-b1_on_gp
12.00Single5WF5UK-4320975WF5-A2A-UK-432097
12.00Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
12.00Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
12.00Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
12.00Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
12.00Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
12.00Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
12.00Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
12.00Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
12.00Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
12.00Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
12.00Single9B5YLong-Acting PTH9B5Y-PTH1-Long-Acting PTH-chim(NtGi1-Gq)/β1/γ2
12.00Single9M1OMorphine-Modulating Neuropeptide B9M1O-NPFF2-Morphine-Modulating Neuropeptide B-Gi1/β1/γ2
12.00Consensusclass-b1_class-b2_cons_onOrthosteric Ligandclass-b1_on class-b2_on
12.00Consensusclass-b1_class-b2_cons_on_gpOrthosteric Ligandclass-b1_on_gp class-b2_on_gp
12.00Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
12.00Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
12.00Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
12.00Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
12.00Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
12.00Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
11.76Single3REYXAC3REY-A2A-XAC
11.76Single6AQFZM-2413856AQF-A2A-ZM-241385
11.76Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
11.76Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
11.76Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
11.76Single6ZINSR486926ZIN-NTS1-SR48692
11.76Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
11.76Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
11.76Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
11.76Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
11.76Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
11.76Single8Y6YGLPG09748Y6Y-FFA2-GLPG0974
11.76Single8YRGFospropofol8YRG-MRGPRX4-Fospropofol-chim(NtGi1-Gs-CtGq)/β1/γ2
11.76Single8ZPMAMD0708ZPM-CXCR4-AMD070
11.76Single8ZPNAMD31008ZPN-CXCR4-AMD3100
11.76Single9BA0A1AKN9BA0-CB1-A1AKN
11.76Single9IXXLTD49IXX-CysLT2-LTD4-chim(NtGi1-Gs-CtGq)/β1/γ2
11.76Single9JH3CMF-0199JH3-Apelin-CMF-019-Gi1/β1/γ2
11.76Single9JMDAzithromycin9JMD-Motilin-Azithromycin-chim(Gs-CtGq)/β1/γ2
11.76Single9M2FNeuropeptide FF9M2F-NPFF1-Neuropeptide FF-Gi1/β1/γ2
11.76Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
11.76Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
11.76Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
11.76Consensuspth_onOrthosteric Ligandpth1_on pth2_on
11.54Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
11.54Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
11.54Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
11.54Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
11.54Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
11.54Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
11.54Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
11.54Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
11.54Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
11.54Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ2
11.54Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
11.54Single9EBOGLP-1 (ACPC18)9EBO-GLP-1-GLP-1 (ACPC18)-Gs/β1/γ2
11.54Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
11.54Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
11.54Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
11.54Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
11.54Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
11.11Single4QIMANTA XV4QIM-SMO-ANTA XV
11.11Single5TGZAM65385TGZ-CB1-AM6538
11.11Single5UENDU1725UEN-A1-DU172
11.11Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
11.11Single6D35Cholesterol6D35-SMO-Cholesterol
11.11Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
11.11Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
11.11Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
11.11Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
11.11Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
11.11Single6UO8SKF975416UO8-GABAB1, GABAB2-SKF97541-GS39783
11.11Single6UO9SKF975416UO9-GABAB1, GABAB2-SKF97541
11.11Single6W2XPubChem 53110426W2X-GABAB1, GABAB2-PubChem 5311042
11.11Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042
11.11Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042
11.11Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
11.11Single6XBM5LWE6XBM-SMO-5LWE-Gi1/β1/γ2
11.11Single7C7QBaclofen7C7Q-GABAB1, GABAB2-Baclofen-BHFF
11.11Single7C7SCGP546267C7S-GABAB1, GABAB2-CGP54626
11.11Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
11.11Single7CUMCGP546267CUM-GABAB1, GABAB2-CGP54626
11.11Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
11.11Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
11.11Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
11.11Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
11.11Single7DGEQuisqualate7DGE-mGlu1; mGlu1-Quisqualate
11.11Single7DTTCa7DTT-CaS-Ca-Ca
11.11Single7DTTCa7DTT-CaS-Ca-Ca
11.11Single7DTUTryptophan7DTU-CaS-Tryptophan
11.11Single7DTUTryptophan7DTU-CaS-Tryptophan
11.11Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
11.11Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
11.11Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
11.11Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
11.11Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
11.11Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
11.11Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
11.11Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
11.11Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
11.11Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
11.11Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
11.11Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
11.11Single7EB2Baclofen7EB2-GABAB2; GABAB1-Baclofen-rac-BHFF-Gi1/β1/γ2
11.11Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
11.11Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
11.11Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
11.11Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
11.11Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
11.11Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
11.11Single7FIHhCG7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
11.11Single7FIIhCG7FII-LH-hCG-chim(NtGi1-Gs)/β1/γ2
11.11Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
11.11Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
11.11Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
11.11Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
11.11Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
11.11Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
11.11Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
11.11Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
11.11Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
11.11Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
11.11Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
11.11Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
11.11Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
11.11Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
11.11Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
11.11Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
11.11Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
11.11Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
11.11Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
11.11Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
11.11Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
11.11Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
11.11Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
11.11Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
11.11Single7T9NM22 Fab7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
11.11Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
11.11Single7V3ZCP559407V3Z-CB1-CP55940
11.11Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
11.11Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
11.11Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
11.11Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
11.11Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
11.11Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
11.11Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
11.11Single7XW6M22 Fab7XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
11.11Single7XW7K1-707XW7-TSH-K1-70
11.11Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
11.11Single8CU6LJ-45178CU6-A2A-LJ-4517
11.11Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
11.11Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
11.11Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
11.11Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
11.11Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
11.11Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
11.11Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
11.11Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
11.11Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
11.11Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
11.11Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
11.11Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
11.11Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
11.11Single8JD0Glutamate8JD0-mGlu2; mGlu3-Glutamate-NAM563
11.11Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
11.11Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
11.11Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
11.11Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
11.11Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
11.11Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
11.11Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
11.11Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
11.11Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
11.11Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
11.11Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
11.11Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
11.11Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
11.11Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
11.11Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
11.11Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
11.11Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
11.11Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
11.11Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
11.11Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
11.11Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
11.11Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
11.11Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
11.11Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
11.11Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
11.11Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
11.11Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
11.11Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
11.11Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
11.11Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
11.11Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
11.11Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
11.11Single8WG9(2S)-2-amino-4-phosphonobutanoic acid8WG9-mGlu4; mGlu2-(2S)-2-amino-4-phosphonobutanoic acid
11.11Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
11.11Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
11.11Single8WGCLY3792688WGC-mGlu4; mGlu2-LY379268
11.11Single8WGDWAG; WA68WGD-mGlu4; mGlu2-WAG; WA6
11.11Single8WGDWAG; WA68WGD-mGlu4; mGlu2-WAG; WA6
11.11Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
11.11Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
11.11Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.11Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.11Single8WVXNorrin8WVX-LGR4-Norrin
11.11Single8WVYNorrin8WVY-LGR4-Norrin
11.11Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
11.11Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
11.11Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
11.11Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
11.11Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
11.11Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
11.11Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
11.11Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
11.11Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
11.11Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
11.11Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
11.11Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
11.11Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
11.11Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
11.11Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
11.11Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
11.11Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
11.11Single8XUMR-spondin-28XUM-LGR4-R-spondin-2
11.11Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
11.11Single8ZYYNeurotensin peptide 8-138ZYY-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
11.11Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
11.11Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
11.11Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
11.11Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
11.11Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
11.11Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
11.11Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
11.11Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
11.11Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
11.11Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
11.11Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
11.11Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
11.11Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
11.11Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
11.11Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
11.11Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
11.11Single9H37A1IR09H37-A2A-A1IR0-Na
11.11Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
11.11Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
11.11Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
11.11Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
11.11Single9KHHNorrin9KHH-LGR4-Norrin
11.11Single9S37NB219S37-LGR4-NB21
11.11Single9UTBSucralose9UTB-TAS1R2; TAS1R3-Sucralose
11.11Consensusa3_onOrthosteric Liganda3a_on
11.11Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
11.11Consensuscalcitonin_onOrthosteric Ligandctlike_on
11.11Consensuscck_offOrthosteric Ligandccka_off
11.11Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
11.11Consensusclass-b1_onOrthosteric Ligandglucagon_on vip-pacap_on pth_on crf_on calcitonin_on
11.11Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
11.11Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
11.11Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
11.11Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
11.11Consensusvpac_onOrthosteric Ligandvpac1_on vpac2_on
10.71Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
10.71Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
10.71Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
10.71Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
10.71Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
10.71Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
10.71Single9BLBCagrilintide backbone (non-acylated)9BLB-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
10.71Consensuscalcitonin_on_gpOrthosteric Ligandctlike_on_gp
10.71Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
10.71Consensusvpac1_on_gpOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
10.71Consensusvpac_on_gpOrthosteric Ligandvpac1_on_gp vpac2_on_gp
10.53Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
10.53Single5C1MBU725C1M-μ-BU72
10.53Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
10.53Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
10.53Single6D26Fevipiprant6D26-DP2-Fevipiprant
10.53Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
10.53Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
10.53Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
10.53Single6Z4SSR486926Z4S-NTS1-SR48692
10.53Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
10.53Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
10.53Single7LD3Adenosine7LD3-A1-Adenosine-MIPS521-Gi2/β1/γ2
10.53Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
10.53Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
10.53Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
10.53Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
10.53Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.53Single8JXSPF-61428JXS-D1-PF-6142
10.53Single8S4DCMF-0198S4D-Apelin-CMF-019
10.53Single8TF5Oleic acid8TF5-GPR6-Oleic acid
10.53Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
10.53Single9B9ZA1AKO9B9Z-CB1-A1AKO
10.53Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
10.53Single9EHSLUF76029EHS-A3A-LUF7602
10.53Single9F34FOB02-04A9F34-D3-FOB02-04A-Go/β1/γ2
10.53Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
10.53Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
10.53Consensusa3_on_gpOrthosteric Liganda3a_on_gp
10.53Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
10.53Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
10.53Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
10.53Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
10.53Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
10.53Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
10.53Consensusdp_offOrthosteric Liganddp2_off
10.53Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
10.53Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
10.53Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
10.53Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
10.53Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
10.53Consensuspth_on_gpOrthosteric Ligandpth1_on_gp pth2_on_gp
10.53Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
10.53Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
10.34Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
10.34Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
10.34Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
10.34Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
10.34Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
10.34Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
10.34Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
10.34Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
10.34Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
10.34Single8W8XBeta-MSH8W8X-MC3-β-MSH-Ca-Gs/β1/γ2
10.34Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
10.34Single9KDFRES-701-39KDF-ETB-RES-701-3
10.34Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
10.34Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
10.34Consensusglp2_on_gpOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
10.34Consensusglp_onOrthosteric Ligandglp1_on glp2_on
10.34Consensusglp_on_gpOrthosteric Ligandglp1_on_gp glp2_on_gp
10.00Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
10.00Single5TZRMK86665TZR-FFA1-MK8666
10.00Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
10.00Single5XR8AM8415XR8-CB1-AM841
10.00Single5XRAAM115425XRA-CB1-AM11542
10.00Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
10.00Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
10.00Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
10.00Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
10.00Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
10.00Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
10.00Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
10.00Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
10.00Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
10.00Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
10.00Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
10.00Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
10.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
10.00Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
10.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
10.00Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
10.00Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
10.00Single7FEECP559407FEE-CB1-CP55940-ZCZ011
10.00Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
10.00Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
10.00Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
10.00Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
10.00Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
10.00Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
10.00Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
10.00Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
10.00Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
10.00Single8E0GBU728E0G-μ-BU72
10.00Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
10.00Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
10.00Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
10.00Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
10.00Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
10.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
10.00Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
10.00Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
10.00Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
10.00Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
10.00Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
10.00Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
10.00Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
10.00Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
10.00Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
10.00Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
10.00Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
10.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
10.00Single9BQ3Cagrilintide9BQ3-CT (AMY2)-Cagrilintide-Gs/β1/γ2; RAMP2
10.00Single9IK9SST analogue9IK9-SST1-SST analogue-Gi1/β1/γ2
10.00Single9UY3Anamorelin9UY3-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Consensusa2_onOrthosteric Liganda2b_on
10.00Consensusa2_on_gpOrthosteric Liganda2b_on_gp
10.00Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
10.00Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
10.00Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
10.00Consensusclass-b1_on_gpOrthosteric Ligandglucagon_on_gp vip-pacap_on_gp pth_on_gp crf_on_gp calcitonin_on_gp
10.00Consensusclass-b2_onOrthosteric Ligandadgrg_on adgrf_on adgrl_on adgre_on adgrd_on
10.00Consensusclass-b2_on_gpOrthosteric Ligandadgrg_on_gp adgrf_on_gp adgrl_on_gp adgre_on_gp adgrd_on_gp
10.00Consensusctlike_on_gpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
10.00Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
10.00Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
10.00Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
10.00Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
10.00Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
10.00Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
10.00Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
10.00Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
10.00Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
10.00Consensusrelaxin_onOrthosteric Ligandrxfp4_on
10.00Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
10.00Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
10.00Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
10.00Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
10.00Consensusvpac2_on_gpOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
9.68Single7RBTTirzepatide7RBT-GIP-Tirzepatide-LSN3556672-chim(NtGi1-Gs)/β1/γ2
9.68Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
9.68Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
9.68Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
9.68Consensusbombesin_onOrthosteric Ligandbb2_on
9.68Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
9.68Consensusgip_onOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
9.68Consensusgip_on_gpOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
9.68Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
9.52Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
9.52Single4PY02MeSATP4PY0-P2Y12-2MeSATP
9.52Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
9.52Single5TZYMK8666; AP85TZY-FFA1-MK8666; AP8
9.52Single6KQICP559406KQI-CB1-CP55940-Org27569
9.52Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
9.52Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
9.52Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
9.52Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
9.52Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
9.52Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
9.52Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
9.52Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
9.52Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
9.52Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
9.52Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
9.52Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
9.52Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
9.52Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
9.52Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
9.52Single8Y6WTUG-13758Y6W-FFA2-TUG-1375-4-CMTB-Gi1/β1/γ2
9.52Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
9.52Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
9.52Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
9.52Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
9.52Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
9.52Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
9.52Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
9.52Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
9.52Consensusorexin_onOrthosteric Ligandox2_on
9.52Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
9.52Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
9.52Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
9.52Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
9.38Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
9.38Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
9.38Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
9.09Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
9.09Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
9.09Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
9.09Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
9.09Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
9.09Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
9.09Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
9.09Single7KNUCalcitonin gene-related peptide-17KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
9.09Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
9.09Single7T9MCS-17 Antibody7T9M-TSH-CS-17 Antibody
9.09Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
9.09Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
9.09Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
9.09Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.09Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
9.09Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
9.09Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
9.09Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
9.09Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
9.09Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
9.09Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
9.09Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
9.09Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
9.09Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
9.09Single9C0KExendin-49C0K-GLP-1-Exendin-4-Gs/β1/γ2
9.09Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
9.09Single9M54Neuropeptide VF9M54-NPFF2-Neuropeptide VF-Gi1/β1/γ2
9.09Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
9.09Consensuschemerin_onOrthosteric Ligandcml1_on
9.09Consensuscrf_on_gpOrthosteric Ligandcrf2_on_gp crf1_on_gp
9.09Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
9.09Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
9.09Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
9.09Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
9.09Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
9.09Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
9.09Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
9.09Consensusprostanoid_offOrthosteric Ligandep_off dp_off
8.82Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
8.82Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
8.82Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
8.82Consensusglucagon_onOrthosteric Ligandglp_on gluc_on secretin_on gip_on
8.82Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
8.70Single3NY9ICI118-5513NY9-β2-ICI118-551
8.70Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
8.70Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
8.70Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.70Single7XN9L-054,5227XN9-SST2-L-054,522
8.70Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
8.70Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
8.70Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
8.70Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
8.70Single9CM7TUG-13759CM7-FFA2-TUG-1375-AZ-1729-Gi1/β1/γ2
8.70Single9M0RNeuropeptide VF9M0R-NPFF1-Neuropeptide VF-Gi1/β1/γ2
8.70Single9NS9TUG-13759NS9-FFA2-TUG-1375-Compound 187-Gi1/β1/γ2
8.70Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
8.70Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
8.70Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
8.70Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
8.57Consensusgluc_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
8.57Consensusglucagon_on_gpOrthosteric Ligandglp_on_gp gluc_on_gp secretin_on_gp gip_on_gp
8.33Single4IARErgotamine4IAR-5-HT1B-Ergotamine
8.33Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
8.33Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
8.33Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
8.33Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
8.33Single7FIGhCG7FIG-LH-hCG-chim(NtGi1L-Gs)/β1/γ2
8.33Single7QA8Peptide7QA8-STE2-Peptide
8.33Single7QA8Peptide7QA8-STE2-Peptide
8.33Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
8.33Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
8.33Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
8.33Single7UTZTR14027UTZ-TSH-TR1402-DPPC-Gs/β1/γ2
8.33Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Single7XW5TSH7XW5-TSH-TSH-ML109-Gs/β1/γ2
8.33Single7ZI0Cholesterol7ZI0-SMO-SAG-Cholesterol
8.33Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
8.33Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
8.33Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
8.33Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
8.33Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
8.33Single8ZBJSomatostatin-148ZBJ-SST5-Somatostatin-14-Gi1/β1/γ2
8.33Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
8.33Single9BUECagrilintide9BUE-CT-Cagrilintide-Gs/β1/γ2
8.33Single9HB3Mambaquaretin-19HB3-V2-Mambaquaretin-1
8.33Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
8.33Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
8.33Consensusgluc_on_gpOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
8.33Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
8.11Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
8.11Consensuspth2_on_gpOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
8.00Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
8.00Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
8.00Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
8.00Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
8.00Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
8.00Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
8.00Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
8.00Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
8.00Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
8.00Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
8.00Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
7.89Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
7.69Single5L7DCholesterol5L7D-SMO-Cholesterol
7.69Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
7.69Single6PT2KGCHM076PT2-δ-KGCHM07
7.69Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
7.69Single7T9ITSH7T9I-TSH-TSH-Gs/β1/γ2
7.69Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
7.69Single8HS2Fab0468HS2-GPR20-Fab046
7.69Single8I2GGlycoprotein hormones alpha chain8I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
7.69Single8PWNTheophylline8PWN-A2A-Theophylline
7.69Single8W8YGamma-MSH8W8Y-MC3-γ-MSH-Ca-Gs/β1/γ2
7.69Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
7.69Single8X9S5alpha-DHT8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
7.69Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
7.69Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
7.69Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
7.69Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
7.41Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
7.41Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
7.41Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
7.41Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
7.41Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
7.41Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
7.41Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
7.41Single9BLCCagrilintide backbone (non-acylated)9BLC-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
7.41Single9BUDCagrilintide9BUD-CT-Cagrilintide-Gs/β1/γ2
7.41Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
7.41Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
7.41Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
7.41Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
7.41Consensusvasop-oxy_onOrthosteric Ligandv2_on
7.41Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
7.14Single3RFMCaffeine3RFM-A2A-Caffeine
7.14Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
7.14Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
7.14Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
7.14Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
7.14Single9EE9Adenosine9EE9-A2A-Adenosine-Gs/β1/γ2
7.14Consensusvpac1_onOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
6.90Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
6.90Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
6.90Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
6.90Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
6.90Single9BLWCagrilintide backbone (non-acylated)9BLW-CT (AMY1)-Cagrilintide backbone (non-acylated)-Gs/β1/γ2; RAMP1
6.90Single9BP3Cagrilintide9BP3-CT (AMY1)-Cagrilintide-Gs/β1/γ2; RAMP1
6.90Single9BUBCagrilintide9BUB-CT-Cagrilintide-Gs/β1/γ2
6.90Consensuscrf2_on_gpOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
6.90Consensussecretin_onOrthosteric Ligand7D3S-Secretin-Secretin-Gs/β1/γ2
6.67Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
6.67Single3OE6IT1t3OE6-CXCR4-IT1t
6.67Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
6.67Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
6.67Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
6.67Single6ME5Agomelatine6ME5-MT1-Agomelatine
6.67Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
6.67Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
6.67Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
6.67Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
6.67Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
6.67Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
6.67Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
6.67Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
6.67Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
6.67Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
6.67Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
6.67Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
6.67Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
6.67Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
6.67Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
6.67Single8J6QCompound 9n8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
6.67Single8W8WAlpha-MSH8W8W-MC3-α-MSH-Ca-Gs/β1/γ2
6.67Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
6.67Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
6.67Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
6.67Single9BUCCagrilintide9BUC-CT-Cagrilintide-Gs/β1/γ2
6.67Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
6.67Single9JHJC18:0 Ceramide9JHJ-FPR2-ALX-C18:0 Ceramide-Gi1/β1/γ2
6.67Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
6.67Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
6.67Consensussecretin_on_gpOrthosteric Ligand7D3S-Secretin-Secretin-Gs/β1/γ2
6.45Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
6.45Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
6.45Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
6.45Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
6.45Single9BTWCagrilintide9BTW-CT (AMY3)-Cagrilintide-Gs/β1/γ2; RAMP3
6.25Single3OE9IT1t3OE9-CXCR4-IT1t
6.25Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
6.25Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
6.25Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
6.25Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
6.25Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
6.25Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
6.25Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.25Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
6.25Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
6.25Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
6.25Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
6.25Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
6.25Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
6.25Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
6.25Single8HSCFab0468HSC-GPR20-Fab046-Gi1/β1/γ2
6.25Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
6.25Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
6.25Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/β1/γ2
6.25Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
6.25Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
6.25Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
6.25Single8K5BNiacin8K5B-HCA2-Niacin
6.25Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
6.25Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
6.25Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
6.25Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
6.25Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
6.25Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
6.25Single9LMPNE52-QQ579LMP-GPR4-NE52-QQ57
6.25Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
6.25Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
6.25Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg4_on
6.25Consensusadgrg_on_gpOrthosteric Ligandadgrg2_on_gp adgrg4_on_gp
6.06Single9AUCCalcitonin gene-related peptide-19AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
5.88Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
5.88Single3ODUIT1t3ODU-CXCR4-IT1t
5.88Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
5.88Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
5.88Single5ZKQABT-4915ZKQ-PAF-ABT-491
5.88Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
5.88Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
5.88Single6ME2Ramelteon6ME2-MT1-Ramelteon
5.88Single6ME9Ramelteon6ME9-MT2-Ramelteon
5.88Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
5.88Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
5.88Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
5.88Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
5.88Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.88Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
5.88Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
5.88Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
5.88Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
5.88Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.88Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.88Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.88Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
5.88Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
5.88Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
5.88Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
5.88Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
5.88Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
5.88Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
5.88Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.88Single8T3VDocosa-4,7,10,13,16,19-Hexaenoic acid8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.88Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
5.88Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
5.88Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
5.88Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
5.88Single9EBHAdenosine9EBH-A3A-Adenosine-Gi1/β1/γ2
5.88Single9EEAAdenosine9EEA-A2A-Adenosine-Gs/β1/γ2
5.88Single9H2XA1IR19H2X-A2A-A1IR1-Na
5.88Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
5.88Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
5.88Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
5.88Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
5.88Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
5.56Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
5.56Single2YDOAdenosine2YDO-A2A-Adenosine
5.56Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
5.56Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
5.56Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
5.56Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
5.56Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
5.56Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
5.56Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
5.56Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
5.56Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
5.56Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
5.56Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
5.56Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
5.56Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
5.56Single7F61PF-036547467F61-H3-PF-03654746
5.56Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
5.56Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
5.56Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
5.56Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
5.56Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
5.56Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.56Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
5.56Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
5.56Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
5.56Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
5.56Single8IHKAcifran8IHK-HCA3-Acifran
5.56Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
5.56Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
5.56Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
5.56Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
5.56Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
5.56Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
5.56Single8K2WAMG4878K2W-CXCR3-AMG487
5.56Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
5.56Single8K5CAcipimox8K5C-HCA2-Acipimox
5.56Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
5.56Single8K9LDamgo8K9L-μ-Damgo-BMS-986122-Gi3/β1/γ1
5.56Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
5.56Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.56Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
5.56Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
5.56Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
5.56Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
5.56Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
5.56Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
5.56Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
5.56Single9JFUNE52-QQ579JFU-GPR4-NE52-QQ57
5.56Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
5.56Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Gi1/β1/γ2
5.56Single9KPDSA09KPD-TAS2R16-SA0-chim(Gs-CtGt3)/β1/γ2
5.56Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
5.56Consensushca_onOrthosteric Ligandhca2_on
5.56Consensusopsins_offOrthosteric Ligandrhodopsin_off
5.56Consensussensory_offOrthosteric Ligandopsins_off
5.26Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
5.26Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
5.26Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
5.26Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
5.26Single5UIGCmpd-15UIG-A2A-Cmpd-1
5.26Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
5.26Single6IIVDaltroban6IIV-TXA2-Daltroban
5.26Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
5.26Single6PS1Timolol6PS1-β2-Timolol
5.26Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
5.26Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
5.26Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
5.26Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
5.26Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
5.26Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
5.26Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
5.26Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
5.26Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
5.26Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
5.26Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
5.26Single7YXAONO-54306087YXA-S1P5-ONO-5430608
5.26Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
5.26Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.26Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
5.26Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
5.26Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
5.26Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
5.26Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
5.26Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
5.26Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
5.26Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
5.26Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
5.26Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
5.26Single8JXRLSD8JXR-D1-LSD
5.26Single8T1WCVN4248T1W-GPR6-CVN424
5.26Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.26Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.26Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.26Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.26Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.26Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
5.26Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
5.26Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
5.26Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
5.26Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
5.26Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
5.26Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
5.26Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
5.26Single9CHXS-Carazolol9CHX-β2-S-Carazolol
5.26Single9IVGGLP-1 (Truncated)9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
5.26Single9IYAONO-97105319IYA-GPR55-ONO-9710531
5.26Single9IZCMK19039IZC-HCA2-MK1903-Gi1/β1/γ2
5.26Single9KFJPubChem 1383196749KFJ-RXFP3-PubChem 138319674-Gi2/β1/γ2
5.26Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
5.26Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
5.26Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
5.26Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
5.26Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
5.26Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
5.26Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
5.26Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
5.26Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
5.26Consensushca_on_gpOrthosteric Ligandhca2_on_gp
5.00Single4NTJAZD12834NTJ-P2Y12-AZD1283
5.00Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
5.00Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
5.00Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
5.00Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
5.00Single6LUQHaloperidol6LUQ-D2-Haloperidol
5.00Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
5.00Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
5.00Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
5.00Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
5.00Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
5.00Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
5.00Single7C4SS1P7C4S-S1P3-S1P
5.00Single7C61Ergotamine7C61-5-HT1B-Ergotamine
5.00Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
5.00Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
5.00Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
5.00Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
5.00Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
5.00Single7W41PD1762527W41-BB2-PD176252
5.00Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
5.00Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
5.00Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
5.00Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.00Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
5.00Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
5.00Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
5.00Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
5.00Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
5.00Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.00Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
5.00Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
5.00Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
5.00Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
5.00Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
5.00Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
5.00Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
5.00Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.00Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.00Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
5.00Single8WGBVU01550418WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
5.00Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
5.00Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
5.00Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
5.00Single8ZVZBW245C8ZVZ-DP1-BW245C-Gs/β1/γ2
5.00Single9CIBFCH-22964139CIB-HCA2-FCH-2296413
5.00Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single9EE8Adenosine9EE8-A2A-Adenosine-Gs/β1/γ2
5.00Single9GE2ML1849GE2-GPR55-ML184-chim(NtGi1-G13)/β1/γ2
5.00Single9I52A1IZU9I52-D1-A1IZU-Gs/β1/γ2
5.00Single9KPFSA09KPF-TAS2R16-SA0-Gi1/β1/γ2
5.00Consensusadgrg2_onOrthosteric Ligand7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
5.00Consensusadgrg2_on_gpOrthosteric Ligand7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
5.00Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
5.00Consensusbombesin_offOrthosteric Ligandbb2_off
5.00Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
5.00Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
5.00Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
5.00Consensusep_offOrthosteric Ligandep4_off
5.00Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
5.00Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
5.00Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
5.00Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
5.00Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
5.00Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.00Consensustrace-amine_onOrthosteric Ligandta1_on
4.76Single2YDVNECA2YDV-A2A-NECA
4.76Single3P0GBI1671073P0G-β2-BI167107
4.76Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
4.76Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
4.76Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
4.76Single4UHRCGS216804UHR-A2A-CGS21680
4.76Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
4.76Single5G53NECA5G53-A2A-NECA-Gs
4.76Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
4.76Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
4.76Single6J21Aprepitant6J21-NK1-Aprepitant
4.76Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
4.76Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
4.76Single7B6WCyclazosin7B6W-α1b-Cyclazosin
4.76Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
4.76Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
4.76Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
4.76Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
4.76Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
4.76Single7R0CAVP7R0C-V2-AVP-Arrestin2
4.76Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
4.76Single7TUYGSK682753A7TUY-GPR183-GSK682753A
4.76Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
4.76Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
4.76Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
4.76Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
4.76Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
4.76Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
4.76Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
4.76Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
4.76Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
4.76Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
4.76Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
4.76Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
4.76Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
4.76Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
4.76Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
4.76Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
4.76Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
4.76Single8Y73Peptide8Y73-μ-Peptide-MPAM-15-Gi1/β1/γ2
4.76Single8ZW0PGD28ZW0-DP1-PGD2-Gs/β1/γ2
4.76Single8ZWFJR14a8ZWF-C3aB-JR14a
4.76Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
4.76Single9BJKNaloxone9BJK-μ-Naloxone-NAM
4.76Single9CLWTUG-13759CLW-FFA2-TUG-1375-4-CMTB-chim(NtGi1L-Gs-CtGq)/β1/γ2
4.76Single9EGOYVF9EGO-CB1-YVF-Gi1/β1/γ2
4.76Single9I54A1IZV9I54-D1-A1IZV-Gs/β1/γ2
4.76Single9JMCDS-3801b9JMC-Motilin-DS-3801b-chim(Gs-CtGq)/β1/γ2
4.76Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
4.76Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
4.76Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
4.76Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
4.76Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
4.76Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
4.76Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
4.76Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
4.76Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
4.55Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
4.55Single4N4WSANT-14N4W-SMO-SANT-1
4.55Single4RWADIPP-NH24RWA-δ-DIPP-NH2
4.55Single6A93Risperidone6A93-5-HT2A-Risperidone
4.55Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
4.55Single6CM4Risperidone6CM4-D2-Risperidone
4.55Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
4.55Single6IIURamatroban6IIU-TXA2-Ramatroban
4.55Single6MXTSalmeterol6MXT-β2-Salmeterol
4.55Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
4.55Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
4.55Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
4.55Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
4.55Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
4.55Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
4.55Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
4.55Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
4.55Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
4.55Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
4.55Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
4.55Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
4.55Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
4.55Single7YITNalfurafine7YIT-κ-Nalfurafine
4.55Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
4.55Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
4.55Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
4.55Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
4.55Single8JJ8Formoterol8JJ8-β2-Formoterol
4.55Single8JJLOlodaterol8JJL-β2-Olodaterol
4.55Single8JWY2-1188JWY-A2A-2-118
4.55Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
4.55Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.55Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
4.55Single8XJNCloprosetnol8XJN-TXA2-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55Single9AU0BW245C9AU0-DP1-BW245C-Gs/β1/γ2
4.55Single9CM3TUG-13759CM3-FFA2-TUG-1375-Compound 187-chim(NtGi1L-Gs-CtGq)/β1/γ2
4.55Single9DGIZ85267113509DGI-CB1-Z8526711350
4.55Single9EBIPiclidenoson9EBI-A3A-Piclidenoson-chim(NtGi1L-Gs-CtGi1)/β1/γ2
4.55Single9GGGI-BOP9GGG-TXA2-I-BOP-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.55Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
4.55Single9M4QDoxazosin9M4Q-Alpha1A-Doxazosin
4.55Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
4.55Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
4.55Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
4.55Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
4.55Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
4.55Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
4.55Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
4.55Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
4.55Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
4.55Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
4.55Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
4.55Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
4.55Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
4.55Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
4.55Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
4.35Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
4.35Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
4.35Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
4.35Single6IBLArformoterol6IBL-β1-Arformoterol
4.35Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
4.35Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
4.35Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
4.35Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
4.35Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
4.35Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
4.35Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
4.35Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
4.35Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
4.35Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
4.35Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
4.35Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
4.35Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
4.35Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
4.35Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
4.35Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35Single8XJOU466198XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35Single8ZWGJR14a8ZWG-C3aB-JR14a-Gi1/β1/γ2
4.35Single9GG5U466199GG5-TXA2-U46619-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.35Single9JH5C16:0 Ceramide9JH5-CysLT2-C16:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35Single9M1HProstaglandin E29M1H-EP1-Prostaglandin E2-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
4.35Consensusfp-alpha_onOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
4.35Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
4.35Consensustp_onOrthosteric Ligand8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35Consensustp_on_gpOrthosteric Ligand8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17Single5ZTYAM102575ZTY-CB2-AM10257
4.17Single6PT3DPI-2876PT3-δ-DPI-287
4.17Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
4.17Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
4.17Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
4.17Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
4.17Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
4.17Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
4.17Single8Y72Peptide8Y72-μ-Peptide-BMS-986122-Gi1/β1/γ2
4.17Single9CGKC5-Quino9CGK-δ-C5-Quino-Gi1/β1/γ2
4.17Single9IPVJR14a9IPV-C3aB-JR14a-Gi1/β1/γ2
4.17Single9IPYJR14a9IPY-C3aB-JR14a
4.17Single9IZASCH9002719IZA-HCA2-SCH900271-Gi1/β1/γ2
4.17Single9JF4PD1683689JF4-BB1-PD168368
4.17Single9JH6C20:0 Ceramide9JH6-CysLT2-C20:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17Single9V2NMacimorelin9V2N-Ghrelin-Macimorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
4.00Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
4.00Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
4.00Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
4.00Single8IEBA1LYA8IEB-GPR156-A1LYA
4.00Single8IEIA1LYA8IEI-GPR156-A1LYA
4.00Single8IEIA1LYA8IEI-GPR156-A1LYA
4.00Single8IEPA1LYA8IEP-GPR156-A1LYA
4.00Single8IEPA1LYA8IEP-GPR156-A1LYA
4.00Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
4.00Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
4.00Single8KIGSHU91198KIG-MC3-SHU9119-Ca
4.00Single8WKYPG-9348WKY-MC4-PG-934
4.00Single8XFTR-spondin-28XFT-LGR4-R-spondin-2-ZNRF3
4.00Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-ZNRF3
3.85Single6HLOAprepitant6HLO-NK1-Aprepitant
3.85Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
3.85Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
3.85Single8IEBA1LYA8IEB-GPR156-A1LYA
3.85Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
3.85Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
3.85Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
3.70Single6W25SHU91196W25-MC4-SHU9119-Ca
3.70Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.70Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
3.70Single8WVUR-spondin-18WVU-LGR4-R-spondin-1-RNF43
3.70Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-ZNRF3
3.70Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
3.57Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
3.57Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
3.57Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
3.57Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
3.57Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
3.57Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
3.57Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
3.57Single8XFPR-spondin-28XFP-LGR4-R-spondin-2-ZNRF3
3.57Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
3.45Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
3.45Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
3.45Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
3.23Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
3.23Single8XFSR-spondin-28XFS-LGR4-R-spondin-2-ZNRF3
3.23Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
3.12Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
3.03Consensuscrf1_onOrthosteric Ligand6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF1-Corticoliberin-Gs/β1/γ2
2.86Consensuscrf1_on_gpOrthosteric Ligand6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF1-Corticoliberin-Gs/β1/γ2

Consensus Members
Id Members
6WWZ 6WWZ-CCR6-CCL20-Go/β1/γ2
Net Summary
Imin 1.75
Number of Linked Nodes 822
Number of Links 944
Number of Hubs 125
Number of Links mediated by Hubs 507
Number of Communities 30
Number of Nodes involved in Communities 193
Number of Links involved in Communities 256
Path Summary
Number Of Nodes in MetaPath 87
Number Of Links MetaPath 86
Number of Shortest Paths 871544
Length Of Smallest Path 3
Average Path Length 36.0498
Length of Longest Path 70
Minimum Path Strength 1.265
Average Path Strength 4.29335
Maximum Path Strength 20.79
Minimum Path Correlation 0.7
Average Path Correlation 0.981016
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.75439
Average % Of Corr. Nodes 45.0464
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 35.5297
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following consensuses:
IdComponents
ccr_on_gpccr6_on_gp
ccr8_on_gp
ccr2_on_gp
ccr1_on_gp
ccr5_on_gp



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Download ccr6_on_gp.zip



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