Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
1b.1x4 3.855408
2b.h2x1 4.324595
3b.h2x5 5.5925495
4b.lhb1x3 4.145492
5b.lhb1x6 4.3975493
6b.b1x6 3.91409
7b.l1x3 10.88254109
8b.b2x1 7.506578
9b.b2x5 6.638537
10b.b3x1 6.764125
11b.b3x4 5.54754109
12b.b4x3 5.035407
13b.b4x4 5.6625108
14b.b4x5 7.0145127
15b.b4x6 6.6665109
16b.l4x2 11.0775434
17b.b5x2 5.1875407
18b.b5x3 6.707147109
19b.b5x5 6.85754125
20b.b5x7 6.255407
21b.l5x1 5.625188
22b.l5x5 7.282519
23b.b6x5 6.161676126
24b.l6x5 5.3975444
25b.b7x1 6.242544
26b.b7x4 3.8665188
27b.l7x4 4.1475409
28b.b8x3 4.2125446
29b.b8x4 6.55186
30b.l8x5 5.784233
31b.b9x4 3.73549
32b.l9x3 7.30333649
33b.l9x6 5.73286718
34b.b10x3 3.784548
35b.b10x5 4.535409
36b.l10x1 4.78833653
37b.b11x3 3.766555
38b.b11x4 4.72549
39b.l11x2 8.21449
40b.b12x5 4.0225456
41b.b12x6 8.58833648
42b.b13x7 7.738557
43b.l13x3 8.3659
44b.l13x6 6.888519
45b.b14x3 4.542555
46b.b14x5 5.2525455
47b.b15x1 7.4575459
48b.b15x3 5.5275459
49b.l15x1 3.985617
50b.b16x4 9.145456
51b.b16x5 4.4075405
52b.b16x6 9.45758
53b.b17x5 7.7175467
54b.b17x7 10.8425468
55b.l17x3 9.95333669
56b.l17x6 7.385419
57b.b18x3 4.452508
58b.b18x5 6.5125405
59b.l18x1 6.45136
60b.b19x2 6.754566
61b.b20x2 6.1625466
62b.b20x4 10.1067668
63b.b20x6 7.32429766
64b.b21x1 10.7425467
65b.b21x4 5.5675405
66b.b21x7 7.985405
67b.l21x5 3.674194
68b.b22x4 3.61485
69b.b22x5 8.4965137
70b.l22x5 6.832599
71b.b23x1 4.3475435
72b.b23x2 6.12254136
73b.b23x3 4.7675487
74b.b23x6 6.556676197
75b.l23x1 9.43406
76b.b24x4 5.8825196
77b.b24x6 8.7954198
78b.l24x2 3.995696
79b.l24x3 4.03495
80b.b25x3 8.0054195
81b.l25x3 7.286589
82b.l25x7 3.955487
83b.b26x3 5.046586
84b.l26x5 5.204535
85b.b27x3 5.55488
86b.l27x1 10.2729779
87b.l27x2 6.5725489
88b.b28x3 3.524507
89b.b28x6 8.758589
90b.b28x7 6.575439
91G.HN.47 3.544106
92G.hns1.03 4.025404
93G.S1.02 5.935145
94G.S1.05 5.635419
95G.S1.06 2.885248
96G.S1.07 4.058519
97G.H1.01 3.30254249
98G.S3.01 4.82754144
99G.S3.03 6.7556146
100G.S3.04 7.926517
101G.S3.06 8.438519
102G.S3.08 4.064519
103G.s3h2.03 5.34519
104G.H2.02 4.695419
105G.H2.03 7.83419
106G.H2.06 6.4125419
107G.H2.07 5.20667618
108G.h2s4.01 7.175417
109G.S4.02 3.2525417
110G.S4.03 4.6875409
111G.S4.06 5.3375418
112G.s4h3.04 6.15333609
113G.H3.02 3.0775414
114G.H3.09 7.47333615
115G.H3.15 4.7125474
116G.H3.17 6.92333679
117G.S5.03 3.6725409
118G.S5.04 4.91419
119G.S5.06 5.6725419
120G.S5.07 4.87254209
121G.hgh4.01 5.00254157
122G.hgh4.02 7.02754155
123G.H4.03 8.63514
124G.H4.15 6.486513
125G.h4s6.02 5.095415
126G.h4s6.11 3.845414
127G.h4s6.12 5.9654115
128G.S6.01 5.5525417
129G.S6.02 6.9865115
130G.S6.05 5.56419
131G.s6h5.01 5.50254207
132G.H5.03 6.6545207
133G.H5.06 7.87408
134G.H5.08 5.1185144
135G.H5.26 8.055115
1361x32 6.99405
1371x56 5.60254287
1381x64 5.90254264
1392x39 3.06254298
1402x42 4.9325408
1412x43 6.24754298
1422x45 6.30254219
1432x53 5.064226
1442x54 3.7585225
1452x57 3.944227
1462x59 6.6754166
147E1x50 5.2945169
1483x30 5.578505
1493x31 5.1625405
1503x32 5.8406
1513x33 11.2875425
1523x37 6.075427
1533x38 7.454217
1543x42 7.2285217
1553x49 6.2225408
156I2x52 11.64175
157I2x53 6.6765175
158I2x56 7.764174
1594x50 6.934219
1605x32 7.335423
1615x36 4.685424
1625x40 8.71625
1635x43 4.815426
1645x58 6.326278
1656x30 5.4745115
1666x37 5.37407
1676x45 7.4375409
1686x48 3.544308
1696x51 5.56714726
1706x55 9.6975425
171E3.P255 4.9725424
1727x42 3.4825407
173g.l1x4 4.3275408
174g.ctx3 6.67539
175g.ctx4 3.855437
176g.ctx5 5.152539
177g.ctx9 3.6325436
178g.ctx15 6.9525439
179g.ctx16 4.82889938
180Lig 12.5829720
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1b.1x19 b.b21x1 20.31479.53NoYes067
2b.b17x7 b.b21x1 13.29899.55YesYes687
3b.1x19 b.b21x2 20.84224.67NoNo066
4b.b21x2 g.h2x1 21.40095.73NoNo068
5b.b21x4 g.h2x1 21.72324.47YesNo058
6b.b21x4 b.h2x1 27.23454.15YesYes055
7b.h2x1 b.l24x2 32.3792.77YesYes956
8b.l22x5 b.l24x2 35.8674.86YesYes996
9b.l22x5 b.lhb1x6 38.04163.92YesYes993
10b.lhb1x6 b.lhb1x9 40.30953.07YesNo033
11b.lhb1x11 b.lhb1x9 18.87432.92NoNo043
12b.b23x1 b.lhb1x9 21.77734.28YesNo053
13b.b11x5 b.l13x7 14.12126.46NoNo069
14b.b10x1 b.b11x5 22.81063.26NoNo096
15b.b10x1 b.b14x1 23.08146.13NoNo098
16b.b14x1 b.l9x6 24.11824.79NoYes088
17G.s3h2.03 b.l9x6 11.20063.38YesYes198
18G.s3h2.03 b.l7x2 12.653410.65YesNo199
19b.b6x1 b.l7x2 25.82412.83NoNo099
20b.b2x1 b.b6x1 25.88624.79YesNo089
21b.b2x1 b.l27x1 51.75556.75YesYes789
22b.l25x6 b.l27x1 52.255215.99NoYes789
23b.l23x1 b.l25x6 53.624725.01YesNo068
24b.b22x1 b.l23x1 55.26652.89NoYes086
25b.b22x1 b.b22x2 55.33866.4NoNo088
26b.b22x2 b.b26x3 55.41247.51NoYes086
27G.H2.07 b.l9x6 17.8793.86YesYes188
28G.H2.07 b.l7x2 13.11295.69YesNo189
29b.lhb1x11 g.ctx5 12.22192.83NoYes049
30b.b23x1 g.ctx5 10.95574.15YesYes359
31b.b22x4 b.b26x3 70.48914.5YesYes856
32b.b22x4 b.b26x4 70.80663.71YesNo055
33b.b26x4 b.b2x3 70.79893.49NoNo056
34b.b27x2 b.b2x3 67.53583.22NoNo056
35b.b27x2 b.b2x5 67.52785.19NoYes057
36b.b2x5 g.ctx16 34.31383.01YesYes378
37b.b26x3 b.b27x3 51.71995.9YesYes868
38b.b27x3 b.l25x3 55.69435.48YesYes889
39b.l25x3 b.l27x2 60.12966.3YesYes899
40G.h2s4.01 b.l5x5 23.093510.02YesYes179
41b.l3x1 b.l5x5 26.02066.57NoYes099
42b.b2x5 b.l4x1 33.54936.18YesNo375
43b.l4x1 b.l4x2 33.51075.09NoYes354
44b.l2x5 b.l4x2 99.940526.75NoYes054
45b.b4x7 b.l2x5 99.756513.1NoNo085
46b.b3x1 b.b4x7 1004.07YesNo058
47b.b3x1 b.b4x5 50.03644.28YesYes1257
48b.b4x5 b.l8x1 24.47234.28YesNo1275
49b.b7x2 b.l8x1 48.5315.96NoNo085
50b.b4x3 b.b7x2 72.15462.98YesNo078
51b.l4x2 g.ctx16 50.1594.13YesYes348
52b.b3x1 b.b6x5 49.591610.55YesYes1256
53b.b6x5 b.l8x1 24.49364.69YesNo1265
54b.b3x3 b.b6x5 24.4945.05NoYes086
55b.b3x3 b.b7x2 24.28153.21NoNo088
56b.b4x5 b.b5x5 25.14237.95YesYes1275
57b.b5x5 b.l8x8 24.72664.15YesNo054
58b.b5x7 b.l8x8 24.513612.29YesNo074
59b.b5x7 b.b8x4 24.09153.63YesYes076
60b.b7x4 b.b8x4 22.35285.38YesYes1886
61b.b7x4 b.b7x5 88.33693.92YesNo089
62b.b7x5 b.l9x7 86.5683.42NoNo097
63b.b11x4 b.l9x7 58.01474.42YesNo497
64b.b10x3 b.b11x4 21.43273.38YesYes489
65b.b4x3 b.l5x1 69.51368.3YesYes078
66b.b7x4 b.l5x1 66.85433.17YesYes1888
67g.ctx3 g.ctx5 24.17096.79YesYes399
68g.ctx3 g.ctx4 34.86544.83YesYes397
69b.l26x5 g.ctx4 33.63095.03YesYes357
70b.b23x1 b.l22x1 11.00013YesNo359
71b.l22x1 g.ctx3 11.00175.89NoYes399
72b.l26x5 g.ctx15 16.422510.06YesYes359
73b.l9x3 b.l9x7 27.66856.43YesNo497
74b.b12x6 b.l9x3 19.64698.46YesYes489
75b.b12x6 b.b9x4 30.36675.69YesYes489
76b.b8x3 b.b9x4 25.01152.85YesYes469
77b.b7x1 b.b8x3 46.44654.84YesYes446
78b.b7x1 b.l6x5 10.72035.81YesYes444
79b.b11x4 b.b12x6 19.64417.28YesYes498
80b.b10x3 b.b8x1 13.40313.64YesNo488
81b.b8x1 b.b8x3 12.50813.27NoYes486
82b.b11x2 b.b11x4 16.07153.04NoYes479
83b.b11x2 b.l12x1 15.18144.42NoNo076
84b.b8x3 b.l12x1 12.50385.89YesNo066
85b.b7x1 b.b8x5 21.43973.49YesNo444
86b.b8x5 b.l8x3 17.86724.39NoNo043
87b.l8x3 b.l8x5 14.29412.82NoYes033
88b.l25x4 b.l27x2 59.35523.99NoYes059
898x56 b.l25x4 59.24489.09NoNo045
903x49 I2x53 30.29616.73YesYes085
912x39 3x49 27.77662.85YesYes088
922x39 2x43 29.29282.98YesYes2988
931x57 2x43 57.7967.31NoYes078
941x57 8x50 57.90844.29NoNo078
951x56 8x50 58.35667.54YesNo078
961x56 8x53 58.887YesNo2875
978x53 8x56 59.13472.6NoNo054
98G.H5.11 G.H5.15 19.30763.07NoNo066
99G.H5.15 I2x54 19.7654.36NoNo064
100G.H5.19 I2x54 19.91948.39NoNo094
101G.H5.19 I2x53 19.91528.14NoYes1795
102G.H5.11 G.S3.03 10.90656.55NoYes1466
103G.S1.04 G.S4.03 14.98028.56NoYes079
104G.S1.05 G.h2s4.01 24.05399.74YesYes197
105G.S1.05 G.S4.02 25.57034.28YesYes197
106G.H3.09 G.H4.15 23.85389.65YesYes153
107G.H3.09 G.S5.02 25.82267.54YesNo158
108G.S4.02 G.S5.02 27.722.94YesNo178
109G.S5.06 G.s4h3.01 11.28495.54YesNo099
110G.HG.04 G.s4h3.01 16.387114.61NoNo059
111G.HG.04 G.s4h3.04 15.33466.19NoYes059
1123x32 7x38 13.27013.65YesNo065
1136x51 7x38 13.43744.69YesNo065
1143x37 6x51 18.17174.96YesYes276
1153x37 5x461 20.998411.72YesNo276
1163x41 5x461 28.36682.77NoNo056
1173x41 4x49 28.51677.94NoNo057
1183x42 4x49 28.96535.59YesNo077
1192x45 3x42 29.82844.83YesYes2197
1202x45 4x46 30.77614.47YesNo096
1212x42 4x46 31.21793YesNo086
1222x42 3x46 28.35244.47YesNo088
1232x43 3x46 28.27772.98YesNo2988
124b.l26x5 g.ctx16 17.33143.73YesYes358
125b.b2x1 b.l3x1 25.961211.27YesNo089
126b.l4x2 g.ctx15 16.46018.34YesYes349
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
3x334x572.792YesNo5612
3x33E2x5111.352YesNo5412
3x336x513.092YesYes5611
3x33Lig27.922YesYes5010
3x374x574.032YesNo7622
3x375x433.592YesYes7621
3x375x46111.722YesNo7622
3x376x514.962YesYes7621
4x565x436.570NoYes4621
4x60Lig11.950NoYes4010
5x365x4012.152YesYes4521
5x406x5514.672YesYes5511
5x40E3.P2552.882YesYes5412
5x407x348.532YesNo5411
5x40Lig12.532YesYes5010
5x435x4614.242YesNo6612
5x43Lig4.862YesYes6010
5x446x554.390NoYes5521
6x516x523.492YesNo6812
6x516x5510.892YesYes6511
6x517x373.792YesNo6612
6x517x384.692YesNo6512
6x51Lig8.062YesYes6010
6x55Lig8.842YesYes5010
7x34Lig13.922NoYes4010
5x406x581.52YesNo5512

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
100.00Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
77.78Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
77.78Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
75.00Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
70.00Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Gi1/β1/γ2
58.33Single4NTJAZD12834NTJ-P2Y12-AZD1283
55.56Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
54.55Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
53.85Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
53.85Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
53.85Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
50.00Single6HLLCP999946HLL-NK1-CP99994
50.00Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
50.00Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
50.00Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
50.00Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
46.15Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
45.45Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
45.45Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
44.44Single3RFMCaffeine3RFM-A2A-Caffeine
42.86Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
42.86Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
42.86Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
42.86Single9BJKNaloxone9BJK-μ-Naloxone-NAM
42.86Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
41.67Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
41.67Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
41.67Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
41.67Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
41.67Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
41.67Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
41.67Single9ARXSerotonin9ARX-5-HT2A-Serotonin
41.67Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
41.67Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
40.00Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
40.00Single4RWADIPP-NH24RWA-δ-DIPP-NH2
40.00Single7YITNalfurafine7YIT-κ-Nalfurafine
40.00Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
40.00Single8Y6WTUG-13758Y6W-FFA2-TUG-1375-4-CMTB-Gi1/β1/γ2
40.00Single9CM3TUG-13759CM3-FFA2-TUG-1375-Compound 187-chim(NtGi1L-Gs-CtGq)/β1/γ2
40.00Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
40.00Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
40.00Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
38.46Single4EJ4Naltrindole4EJ4-δ-Naltrindole
38.46Single5UIGCmpd-15UIG-A2A-Cmpd-1
38.46Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
38.46Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
38.46Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
38.46Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
38.46Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
38.46Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
38.46Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
38.46Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
38.46Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
38.46Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
38.46Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
38.46Consensusa3_onOrthosteric Liganda3a_on
38.46Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
38.46Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
37.50Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
37.50Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
37.50Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
37.50Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
37.50Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
36.36Single3PBLEticlopride3PBL-D3-Eticlopride
36.36Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
36.36Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
36.36Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
36.36Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
36.36Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
36.36Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
36.36Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
36.36Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
36.36Single9IXJHistamine9IXJ-H2-Histamine-Gs/β1/γ2
36.36Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
36.36Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
36.36Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
36.36Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
35.71Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
35.71Single5C1MBU725C1M-μ-BU72
35.71Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
35.71Single5X7DS-Carazolol5X7D-β2-S-Carazolol-Cmpd-15
35.71Single6HLPNetupitant6HLP-NK1-Netupitant
35.71Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
35.71Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
35.71Single7LD3Adenosine7LD3-A1-Adenosine-MIPS521-Gi2/β1/γ2
35.71Single7WC6LSD7WC6-5-HT2A-LSD
35.71Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
35.71Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
35.71Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
35.71Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
35.71Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
35.71Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
35.71Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
35.71Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
35.71Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
35.71Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
35.71Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
35.71Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
35.71Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
35.71Single9ARYSerotonin9ARY-5-HT2A-Serotonin-chim(NtGi1-Gs-CtGq)/β1/γ2
35.71Single9HAPTolvaptan9HAP-V2-Tolvaptan
35.71Consensusa3_on_gpOrthosteric Liganda3a_on_gp
35.71Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
35.71Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
35.71Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
35.71Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
35.29Single3NY9ICI118-5513NY9-β2-ICI118-551
35.29Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
35.29Single6PT3DPI-2876PT3-δ-DPI-287
35.29Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
35.29Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
35.29Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
35.29Single9CM7TUG-13759CM7-FFA2-TUG-1375-AZ-1729-Gi1/β1/γ2
35.29Single9NS9TUG-13759NS9-FFA2-TUG-1375-Compound 187-Gi1/β1/γ2
33.33Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
33.33Single3P0GBI1671073P0G-β2-BI167107
33.33Single3PWHZM-2413853PWH-A2A-ZM-241385
33.33Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
33.33Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
33.33Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
33.33Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
33.33Single6AKXA4R6AKX-CCR5-A4R
33.33Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
33.33Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
33.33Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
33.33Single6J21Aprepitant6J21-NK1-Aprepitant
33.33Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
33.33Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
33.33Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
33.33Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
33.33Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
33.33Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
33.33Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
33.33Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
33.33Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
33.33Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
33.33Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
33.33Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
33.33Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
33.33Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
33.33Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
33.33Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
33.33Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
33.33Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
33.33Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
33.33Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
33.33Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
33.33Single8E0GBU728E0G-μ-BU72
33.33Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
33.33Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
33.33Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
33.33Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
33.33Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
33.33Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
33.33Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
33.33Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
33.33Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
33.33Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
33.33Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
33.33Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
33.33Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
33.33Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
33.33Single8Y73Peptide8Y73-μ-Peptide-MPAM-15-Gi1/β1/γ2
33.33Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
33.33Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
33.33Single8YYWAlpha-ketoglutarate8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
33.33Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
33.33Single9CLWTUG-13759CLW-FFA2-TUG-1375-4-CMTB-chim(NtGi1L-Gs-CtGq)/β1/γ2
33.33Single9EBHAdenosine9EBH-A3A-Adenosine-Gi1/β1/γ2
33.33Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
33.33Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
33.33Single9J0IUDP-Glucuronic acid9J0I-P2Y14-UDP-Glucuronic acid-Gi1/β1/γ2
33.33Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
33.33Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
33.33Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
33.33Consensusa2_onOrthosteric Liganda2b_on
33.33Consensusa2_on_gpOrthosteric Liganda2b_on_gp
33.33Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
33.33Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
33.33Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
33.33Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
33.33Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
33.33Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
33.33Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
33.33Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
33.33Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
33.33Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
33.33Consensuslpa_onOrthosteric Ligandlpa1_on
33.33Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
33.33Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
33.33Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
33.33Consensustachykinin_offOrthosteric Ligandnk1_off
31.58Single9J0FNADH9J0F-P2Y14-NADH-Gi1/β1/γ2
31.25Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
31.25Single4PY02MeSATP4PY0-P2Y12-2MeSATP
31.25Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
31.25Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
31.25Single5TZYMK8666; AP85TZY-FFA1-MK8666; AP8
31.25Single6MXTSalmeterol6MXT-β2-Salmeterol
31.25Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
31.25Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
31.25Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
31.25Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
31.25Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
31.25Single8JD3JNJ-404118138JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
31.25Single8JJ8Formoterol8JJ8-β2-Formoterol
31.25Single8JJLOlodaterol8JJL-β2-Olodaterol
31.25Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
31.25Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
31.25Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
31.25Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
31.25Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
31.25Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
31.25Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
31.25Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
31.25Consensuslpa_offOrthosteric Ligandlpa1_off
31.25Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
31.25Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
31.25Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
30.77Single3REYXAC3REY-A2A-XAC
30.77Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
30.77Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
30.77Single4MBSMaraviroc4MBS-CCR5-Maraviroc
30.77Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
30.77Single5IU7Q274563465IU7-A2A-Q27456346-Na
30.77Single5IUBQ274563445IUB-A2A-Q27456344-Na
30.77Single5JTBZM-2413855JTB-A2A-ZM-241385
30.77Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
30.77Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
30.77Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
30.77Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
30.77Single5UVIZM-2413855UVI-A2A-ZM-241385
30.77Single6AQFZM-2413856AQF-A2A-ZM-241385
30.77Single6MH8ZM-2413856MH8-A2A-ZM-241385
30.77Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
30.77Single6PS0S-Carazolol6PS0-β2-S-Carazolol
30.77Single6PS4ICI118-5516PS4-β2-ICI118-551
30.77Single6PS5S-Propranolol6PS5-β2-S-Propranolol
30.77Single6TPNHTL66416TPN-OX2-HTL6641
30.77Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
30.77Single7AROLUF58337ARO-A2A-LUF5833-Na
30.77Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
30.77Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
30.77Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
30.77Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
30.77Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
30.77Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
30.77Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
30.77Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
30.77Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
30.77Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
30.77Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
30.77Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
30.77Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.77Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.77Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
30.77Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
30.77Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
30.77Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
30.77Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
30.77Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
30.77Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
30.77Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
30.77Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
30.77Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
30.77Single8K9LDamgo8K9L-μ-Damgo-BMS-986122-Gi3/β1/γ1
30.77Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
30.77Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
30.77Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
30.77Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
30.77Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
30.77Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.77Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.77Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
30.77Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
30.77Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
30.77Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
30.77Consensusa2_offOrthosteric Liganda2a_off
30.77Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
30.77Consensusalpha1_onOrthosteric Ligandalpha1a_on
30.77Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
30.77Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
30.77Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
30.77Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
30.77Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
30.00Single6OY9All-trans-Retinal6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
30.00Single6PT2KGCHM076PT2-δ-KGCHM07
30.00Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
30.00Single8A2OTheophylline8A2O-A2A-Theophylline-Na
30.00Single8IWM2-Phenylethylamine8IWM-TA9-2-Phenylethylamine
30.00Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
30.00Consensusgs_histamineOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
30.00Consensush2_onOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
29.41Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
29.41Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
29.41Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
29.41Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
29.41Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
29.41Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
29.41Single7UM4AS26747237UM4-5-HT5A-AS2674723
29.41Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
29.41Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
29.41Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
29.41Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
29.41Single8T3OTUG-8918T3O-FFA4-TUG-891-chim(NtGi2L-Gs-CtGq)/β1/γ2
29.41Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
29.41Single8ZWGJR14a8ZWG-C3aB-JR14a-Gi1/β1/γ2
29.41Single9CGJC6-Quino9CGJ-δ-C6-Quino-Gi1/β1/γ2
29.41Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
28.57Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
28.57Single2Y02Carmoterol2Y02-β1-Carmoterol
28.57Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
28.57Single3EMLZM-2413853EML-A2A-ZM-241385
28.57Single3NY8ICI118-5513NY8-β2-ICI118-551
28.57Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
28.57Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
28.57Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
28.57Single4GBRS-Carazolol4GBR-β2-S-Carazolol
28.57Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
28.57Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
28.57Single5IU8Q274563475IU8-A2A-Q27456347-Na
28.57Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
28.57Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
28.57Single5UENDU1725UEN-A1-DU172
28.57Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
28.57Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
28.57Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
28.57Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
28.57Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
28.57Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
28.57Single6PS1Timolol6PS1-β2-Timolol
28.57Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
28.57Single6S0LZM-2413856S0L-A2A-ZM-241385
28.57Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
28.57Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
28.57Single7BU7BI1671077BU7-β1-BI167107
28.57Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
28.57Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
28.57Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
28.57Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
28.57Single7PYRPSB-21157PYR-A2A-PSB-2115
28.57Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
28.57Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
28.57Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
28.57Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
28.57Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
28.57Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
28.57Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
28.57Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
28.57Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
28.57Single8CU6LJ-45178CU6-A2A-LJ-4517
28.57Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
28.57Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
28.57Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
28.57Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
28.57Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
28.57Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
28.57Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
28.57Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
28.57Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
28.57Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
28.57Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
28.57Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
28.57Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
28.57Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
28.57Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
28.57Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
28.57Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
28.57Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
28.57Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
28.57Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
28.57Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
28.57Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
28.57Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
28.57Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
28.57Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
28.57Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
28.57Single8JXRLSD8JXR-D1-LSD
28.57Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
28.57Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
28.57Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
28.57Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
28.57Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
28.57Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
28.57Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
28.57Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
28.57Single8X64Desloratadine8X64-H1-Desloratadine
28.57Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
28.57Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
28.57Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
28.57Single9CHXS-Carazolol9CHX-β2-S-Carazolol
28.57Single9H37A1IR09H37-A2A-A1IR0-Na
28.57Single9IYAONO-97105319IYA-GPR55-ONO-9710531
28.57Single9PLNN-(5-methylnaphthalen-1-yl)pyridin-4-amine9PLN-α2a-N-(5-methylnaphthalen-1-yl)pyridin-4-amine
28.57Single9PLON-(5-methylnaphthalen-1-yl)pyridin-4-amine9PLO-α2a-N-(5-methylnaphthalen-1-yl)pyridin-4-amine-Go/β1/γ2
28.57Single9PQD(6m)-1-methyl-6-(1,2,5,6-tetrahydropyridin-3-yl)-1h-indole9PQD-α2a-(6m)-1-methyl-6-(1,2,5,6-tetrahydropyridin-3-yl)-1h-indole
28.57Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
28.57Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
28.57Consensus5ht5_onOrthosteric Ligand5ht5a_on
28.57Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
28.57Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
28.57Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
28.57Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
28.57Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
28.57Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
28.57Consensusdopamine_offOrthosteric Ligandd2_off d3_off
28.57Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
28.57Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
28.57Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
28.57Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
28.57Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
27.78Single4UG2CGS216804UG2-A2A-CGS21680
27.78Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
27.78Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
27.78Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
27.78Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
27.78Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
27.78Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
27.78Single8QJ2pN1628QJ2-MC4-pN162-Gs
27.78Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
27.78Single8Y72Peptide8Y72-μ-Peptide-BMS-986122-Gi1/β1/γ2
27.78Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
27.78Single9CGKC5-Quino9CGK-δ-C5-Quino-Gi1/β1/γ2
27.78Single9IPVJR14a9IPV-C3aB-JR14a-Gi1/β1/γ2
27.78Single9JH6C20:0 Ceramide9JH6-CysLT2-C20:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
27.78Single9V2NMacimorelin9V2N-Ghrelin-Macimorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
27.78Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
27.27Single3UZAGTPL92363UZA-A2A-GTPL9236
27.27Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
27.27Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
27.27Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
27.27Single6ME5Agomelatine6ME5-MT1-Agomelatine
27.27Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
27.27Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
27.27Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/β1/γ2
27.27Single7WC5Psilocin7WC5-5-HT2A-Psilocin
27.27Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
27.27Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
27.27Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.27Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.27Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
27.27Single8IW72-Phenylethylamine8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
27.27Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
27.27Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
27.27Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
27.27Consensus5ht2_onOrthosteric Ligand5ht2b_on
27.27Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
27.27Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
27.27Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
26.67Single2RH1S-Carazolol2RH1-β2-S-Carazolol
26.67Single2YCWS-Carazolol2YCW-β1-S-Carazolol
26.67Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
26.67Single5D6LS-Carazolol5D6L-β2-S-Carazolol
26.67Single5IUAQ274563485IUA-A2A-Q27456348-Na
26.67Single5JQHS-Carazolol5JQH-β2-S-Carazolol
26.67Single5N2SPSB365N2S-A1-PSB36
26.67Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
26.67Single5TVNLSD5TVN-5-HT2B-LSD
26.67Single5XPRBosentan5XPR-ETB-Bosentan
26.67Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
26.67Single6E67BI1671076E67-β2-BI167107-Gs(CT)
26.67Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
26.67Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
26.67Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
26.67Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
26.67Single6S0QZM-2413856S0Q-A2A-ZM-241385
26.67Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
26.67Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
26.67Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
26.67Single7C61Ergotamine7C61-5-HT1B-Ergotamine
26.67Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
26.67Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
26.67Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
26.67Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
26.67Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
26.67Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
26.67Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
26.67Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
26.67Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
26.67Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
26.67Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
26.67Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
26.67Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
26.67Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
26.67Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
26.67Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
26.67Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.67Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.67Single8GNEKW-63568GNE-A2A-KW-6356-Na
26.67Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
26.67Single8JXSPF-61428JXS-D1-PF-6142
26.67Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
26.67Single8QOTNanobody-E8QOT-μ-Nanobody-E
26.67Single8S4DCMF-0198S4D-Apelin-CMF-019
26.67Single8TF5Oleic acid8TF5-GPR6-Oleic acid
26.67Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
26.67Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
26.67Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
26.67Single9EE8Adenosine9EE8-A2A-Adenosine-Gs/β1/γ2
26.67Single9EHSLUF76029EHS-A3A-LUF7602
26.67Single9GE2ML1849GE2-GPR55-ML184-chim(NtGi1-G13)/β1/γ2
26.67Single9I52A1IZU9I52-D1-A1IZU-Gs/β1/γ2
26.67Single9K07DSO-5a9K07-BB3-DSO-5a-chim(NtGi2L-Gs-CtGq)/β1/γ2
26.67Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
26.67Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
26.67Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
26.67Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
26.67Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
26.67Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
26.67Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
26.67Consensusadenosine_offOrthosteric Liganda1_off a2_off
26.67Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
26.67Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
26.67Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
26.67Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
26.67Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
26.67Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
26.67Consensusamine_offonOrthosteric Ligandamine_off amine_on
26.67Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
26.67Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
26.67Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
26.67Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
26.67Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
26.67Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
26.67Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
26.67Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
26.67Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
26.67Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
26.67Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
26.67Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
26.67Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
26.67Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
26.67Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
26.32Single4IARErgotamine4IAR-5-HT1B-Ergotamine
26.32Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
26.32Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
26.32Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
26.32Single8IEBA1LYA8IEB-GPR156-A1LYA
26.32Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
26.32Single8WDTphotoNECA8WDT-A2A-photoNECA
26.32Single8WKYPG-9348WKY-MC4-PG-934
26.32Single9BUYLM1899BUY-β2-LM189-Gi1/β1/γ2
26.32Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
26.32Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
26.32Consensuslpl_onOrthosteric Ligands1p_on lpa_on
26.32Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
26.32Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
26.32Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
26.09Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
26.09Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
25.00Single2YDVNECA2YDV-A2A-NECA
25.00Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
25.00Single3QAKUK-4320973QAK-A2A-UK-432097
25.00Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
25.00Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
25.00Single4UHRCGS216804UHR-A2A-CGS21680
25.00Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
25.00Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
25.00Single5D5AS-Carazolol5D5A-β2-S-Carazolol
25.00Single5D5BS-Carazolol5D5B-β2-S-Carazolol
25.00Single5G53NECA5G53-A2A-NECA-Gs
25.00Single5TZRMK86665TZR-FFA1-MK8666
25.00Single5V54Methiothepin5V54-5-HT1B-Methiothepin
25.00Single5XRAAM115425XRA-CB1-AM11542
25.00Single6E59L-7607356E59-NK1-L-760735
25.00Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
25.00Single6H7JIsoprenaline6H7J-β1-Isoprenaline
25.00Single6HLOAprepitant6HLO-NK1-Aprepitant
25.00Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
25.00Single6J20Aprepitant6J20-NK1-Aprepitant
25.00Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
25.00Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
25.00Single6TP4ACT-4622066TP4-OX1-ACT-462206
25.00Single6WGTLSD6WGT-5-HT2A-LSD
25.00Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
25.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
25.00Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
25.00Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
25.00Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
25.00Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
25.00Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
25.00Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
25.00Single7FEECP559407FEE-CB1-CP55940-ZCZ011
25.00Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
25.00Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
25.00Single7PX4PSB-21137PX4-A2A-PSB-2113
25.00Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
25.00Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
25.00Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
25.00Single7SRQLSD7SRQ-5-HT2B-LSD
25.00Single7TUYGSK682753A7TUY-GPR183-GSK682753A
25.00Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
25.00Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
25.00Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
25.00Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
25.00Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
25.00Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
25.00Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
25.00Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
25.00Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
25.00Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
25.00Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
25.00Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
25.00Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
25.00Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
25.00Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
25.00Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
25.00Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
25.00Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
25.00Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
25.00Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
25.00Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
25.00Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
25.00Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
25.00Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
25.00Single8XVLZibotentan8XVL-ETA-Zibotentan
25.00Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
25.00Single8ZWFJR14a8ZWF-C3aB-JR14a
25.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
25.00Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
25.00Single9I54A1IZV9I54-D1-A1IZV-Gs/β1/γ2
25.00Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
25.00Single9IK8SST analogue9IK8-SST1-SST analogue-Gi1/β1/γ2
25.00Single9IK9SST analogue9IK9-SST1-SST analogue-Gi1/β1/γ2
25.00Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
25.00Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single9JMCDS-3801b9JMC-Motilin-DS-3801b-chim(Gs-CtGq)/β1/γ2
25.00Single9KDFRES-701-39KDF-ETB-RES-701-3
25.00Single9UY3Anamorelin9UY3-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Consensus5ht1_offOrthosteric Ligand5ht1b_off
25.00Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
25.00Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
25.00Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
25.00Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
25.00Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
25.00Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
25.00Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
25.00Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
25.00Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
25.00Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
25.00Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
25.00Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
25.00Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
25.00Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
25.00Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
23.81Single6W25SHU91196W25-MC4-SHU9119-Ca
23.81Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
23.81Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
23.81Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
23.81Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
23.81Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
23.81Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
23.81Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
23.81Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
23.81Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
23.53Single3D4STimolol3D4S-β2-Timolol
23.53Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
23.53Single4AMIBucindolol4AMI-β1-Bucindolol
23.53Single4LDEBI1671074LDE-β2-BI167107
23.53Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
23.53Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
23.53Single6KQICP559406KQI-CB1-CP55940-Org27569
23.53Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
23.53Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
23.53Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
23.53Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
23.53Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
23.53Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
23.53Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
23.53Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
23.53Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
23.53Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
23.53Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
23.53Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
23.53Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
23.53Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
23.53Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
23.53Single8JWY2-1188JWY-A2A-2-118
23.53Single8JWZAB9288JWZ-A2A-AB928-Na
23.53Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
23.53Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
23.53Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
23.53Single9EBIPiclidenoson9EBI-A3A-Piclidenoson-chim(NtGi1L-Gs-CtGi1)/β1/γ2
23.53Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
23.53Single9M4QDoxazosin9M4Q-Alpha1A-Doxazosin
23.53Consensusalpha1_offOrthosteric Ligandalpha1a_off
23.53Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
23.53Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
23.53Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
23.53Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
23.53Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
23.53Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
23.53Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
23.53Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
23.53Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
23.53Consensuslpl_offOrthosteric Ligands1p_off lpa_off
23.53Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
23.53Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
23.53Consensusorexin_onOrthosteric Ligandox2_on
23.53Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
23.53Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
23.08Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
23.08Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
23.08Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
23.08Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
23.08Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
23.08Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
23.08Single5WS3EMPA5WS3-OX2-EMPA
23.08Single6AKYMaraviroc6AKY-CCR5-Maraviroc
23.08Single6B73MP11046B73-κ-MP1104
23.08Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
23.08Single6DS0Ly2660976DS0-5-HT2B-Ly266097
23.08Single6ME2Ramelteon6ME2-MT1-Ramelteon
23.08Single6ME9Ramelteon6ME9-MT2-Ramelteon
23.08Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
23.08Single6TODEMPA6TOD-OX1-EMPA-Na
23.08Single7BR3Elagolix7BR3-GnRH1-Elagolix
23.08Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
23.08Single7F8ULintitript7F8U-CCKA-Lintitript
23.08Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
23.08Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
23.08Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
23.08Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.08Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
23.08Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
23.08Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
23.08Single7XRRLemborexant7XRR-OX2-Lemborexant
23.08Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
23.08Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
23.08Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.08Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
23.08Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.08Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
23.08Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
23.08Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
23.08Single8GNGIstradefylline8GNG-A2A-Istradefylline
23.08Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
23.08Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
23.08Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
23.08Single8T3VDocosa-4,7,10,13,16,19-Hexaenoic acid8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.08Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.08Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.08Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.08Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
23.08Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
23.08Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
23.08Single9EEAAdenosine9EEA-A2A-Adenosine-Gs/β1/γ2
23.08Single9H2XA1IR19H2X-A2A-A1IR1-Na
23.08Single9LRBHistamine9LRB-H1-Histamine-Gs/β1/γ2
23.08Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
23.08Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
23.08Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.08Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
23.08Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
23.08Consensusalpha2_offOrthosteric Ligandalpha2c_off
23.08Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
23.08Consensusorexin_offOrthosteric Ligandox2_off ox1_off
23.08Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
23.08Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
23.08Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
23.08Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
22.73Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
22.73Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
22.73Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
22.73Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
22.73Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
22.73Single8ZBISomatostatin-148ZBI-SST3-Somatostatin-14-Gi1/β1/γ2
22.73Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
22.73Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
22.73Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
22.73Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
22.73Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
22.73Consensusvasop-oxy_onOrthosteric Ligandv2_on
22.73Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
22.22Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
22.22Single4A4MAll-trans-Retinal4A4M-Rhodopsin-All-trans-Retinal-Gt(CT)
22.22Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
22.22Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
22.22Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
22.22Single5EN0All-trans-Retinal5EN0-Rhodopsin-All-trans-Retinal-Gt(CT)
22.22Single5MZPCaffeine5MZP-A2A-Caffeine-Na
22.22Single5X93K-87945X93-ETB-K-8794
22.22Single6H7LDobutamine6H7L-β1-Dobutamine
22.22Single6IBLArformoterol6IBL-β1-Arformoterol
22.22Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
22.22Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
22.22Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
22.22Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
22.22Single7EZCUKA7EZC-A2A-UKA
22.22Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
22.22Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
22.22Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
22.22Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
22.22Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
22.22Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
22.22Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
22.22Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
22.22Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
22.22Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
22.22Single8S2TIsoprenaline8S2T-β1-Isoprenaline-chim(NtGi1-Gs)/β1/γ2
22.22Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
22.22Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
22.22Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
22.22Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
22.22Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
22.22Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
22.22Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
22.22Consensusendothelin_offOrthosteric Ligandetb_off
22.22Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
22.22Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
22.22Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
22.22Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
22.22Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
22.22Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
21.74Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
21.74Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
21.74Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
21.74Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
21.74Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
21.74Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
21.43Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
21.43Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
21.43Single3RZECidoxepin3RZE-H1-Cidoxepin
21.43Single4ZJCSB-6740424ZJC-OX1-SB-674042
21.43Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
21.43Single6A94Zotepine6A94-5-HT2A-Zotepine
21.43Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
21.43Single6IQLL7458706IQL-D4-L745870
21.43Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
21.43Single6KUXRS-799486KUX-α2a-RS-79948
21.43Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
21.43Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
21.43Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
21.43Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
21.43Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
21.43Single6TPGEMPA6TPG-OX2-EMPA
21.43Single6TPKRetosiban6TPK-OT-Retosiban
21.43Single6VI4JDTic6VI4-κ-JDTic
21.43Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
21.43Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
21.43Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
21.43Single7T32ZM-2413857T32-A2A-ZM-241385
21.43Single7UL3Famotidine7UL3-H2-Famotidine
21.43Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
21.43Single7VV6C48/807VV6-MRGPRX2-C48/80
21.43Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
21.43Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
21.43Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
21.43Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
21.43Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.43Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
21.43Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
21.43Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
21.43Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
21.43Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
21.43Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
21.43Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
21.43Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
21.43Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
21.43Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
21.43Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
21.43Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
21.43Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
21.43Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
21.43Single8RLNLUF58348RLN-A2A-LUF5834
21.43Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
21.43Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.43Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
21.43Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
21.43Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
21.43Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
21.43Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
21.43Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
21.43Single9AS3LSD9AS3-5-HT2A-LSD
21.43Single9AS4LSD9AS4-5-HT2A-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Single9AS5Mescaline9AS5-5-HT2A-Mescaline
21.43Single9AS6Mescaline9AS6-5-HT2A-Mescaline-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
21.43Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
21.43Single9IXXLTD49IXX-CysLT2-LTD4-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Single9JH3CMF-0199JH3-Apelin-CMF-019-Gi1/β1/γ2
21.43Single9LRDHistamine9LRD-H1-Histamine-Gi1/β1/γ2
21.43Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
21.43Consensusgrh_offOrthosteric Ligandgnrh1_off
21.43Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
21.43Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
21.43Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
21.43Consensusvasop-oxy_offOrthosteric Ligandot_off
21.05Single5WF6UK-4320975WF6-A2A-UK-432097
21.05Single5ZTYAM102575ZTY-CB2-AM10257
21.05Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
21.05Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
21.05Single7XN9L-054,5227XN9-SST2-L-054,522
21.05Single8X5YAstemizole8X5Y-H1-Astemizole
21.05Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
21.05Single9IPYJR14a9IPY-C3aB-JR14a
21.05Single9M0RNeuropeptide VF9M0R-NPFF1-Neuropeptide VF-Gi1/β1/γ2
21.05Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
21.05Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
21.05Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
21.05Consensuskisspeptin_onOrthosteric Ligandkiss1_on
21.05Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
21.05Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
21.05Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
21.05Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
21.05Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
21.05Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
20.83Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
20.83Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
20.00Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
20.00Single2Y01Dobutamine2Y01-β1-Dobutamine
20.00Single2Y04Salbutamol2Y04-β1-Salbutamol
20.00Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
20.00Single3PXOAll-trans-Retinal3PXO-Rhodopsin-All-trans-Retinal
20.00Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
20.00Single4QKX35V4QKX-β2-35V
20.00Single5DYSAll-trans-Retinal5DYS-Rhodopsin-All-trans-Retinal
20.00Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
20.00Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
20.00Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
20.00Single6H7MSalbutamol6H7M-β1-Salbutamol
20.00Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
20.00Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
20.00Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
20.00Single6TOTLemborexant6TOT-OX1-Lemborexant
20.00Single6XBM5LWE6XBM-SMO-5LWE-Gi1/β1/γ2
20.00Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
20.00Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
20.00Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
20.00Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
20.00Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
20.00Single7UL4Alvimopan7UL4-μ-Alvimopan
20.00Single7V3ZCP559407V3Z-CB1-CP55940
20.00Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
20.00Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
20.00Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
20.00Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
20.00Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
20.00Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single7WC4Serotonin7WC4-5-HT2A-Serotonin
20.00Single7WC7Lisuride7WC7-5-HT2A-Lisuride
20.00Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
20.00Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
20.00Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
20.00Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
20.00Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
20.00Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
20.00Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
20.00Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
20.00Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
20.00Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
20.00Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
20.00Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
20.00Single8IEIA1LYA8IEI-GPR156-A1LYA
20.00Single8IEPA1LYA8IEP-GPR156-A1LYA
20.00Single8IEPA1LYA8IEP-GPR156-A1LYA
20.00Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
20.00Single8JJOAlprenolol8JJO-β2-Alprenolol
20.00Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
20.00Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
20.00Single8PJKST1718PJK-5-HT1A-ST171-Gi1/β1/γ1
20.00Single8PWNTheophylline8PWN-A2A-Theophylline
20.00Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
20.00Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
20.00Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
20.00Single8W8WAlpha-MSH8W8W-MC3-α-MSH-Ca-Gs/β1/γ2
20.00Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
20.00Single8X63Mepyramine8X63-H1-Mepyramine
20.00Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
20.00Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
20.00Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
20.00Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
20.00Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
20.00Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
20.00Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
20.00Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
20.00Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
20.00Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
20.00Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
20.00Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
20.00Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
20.00Single9KFJPubChem 1383196749KFJ-RXFP3-PubChem 138319674-Gi2/β1/γ2
20.00Single9M4TSilodosin9M4T-Alpha1A-Silodosin
20.00Consensusalpha2_onOrthosteric Ligandalpha2b_on
20.00Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
20.00Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
20.00Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
20.00Consensuscck_offOrthosteric Ligandccka_off
20.00Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
20.00Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
20.00Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
20.00Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
20.00Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
20.00Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
20.00Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
20.00Consensushistamine_offOrthosteric Ligandh1_off
20.00Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
20.00Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
20.00Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
20.00Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
20.00Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
20.00Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
20.00Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
20.00Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
19.23Single6IGLIRL16206IGL-ETB-IRL1620
19.23Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
19.23Single8IY6Endothelin-18IY6-ETB-Endothelin-1
19.23Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
19.23Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
19.23Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
19.23Consensusbradykinin_onOrthosteric Ligandbk2_on
19.23Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
19.23Consensusendothelin_onOrthosteric Ligandetb_on eta_on
19.23Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
19.23Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
19.23Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
19.05Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
19.05Single8IEBA1LYA8IEB-GPR156-A1LYA
19.05Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
19.05Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
19.05Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
19.05Single9KFIRelaxin-39KFI-RXFP3-Relaxin-3-Gi2/β1/γ2
19.05Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
19.05Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
19.05Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
19.05Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
19.05Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
19.05Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
19.05Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
19.05Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
19.05Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
18.75Single2Y00Dobutamine2Y00-β1-Dobutamine
18.75Single2Y03Isoprenaline2Y03-β1-Isoprenaline
18.75Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
18.75Single5N2RPSB-365N2R-A2A-PSB-36-Na
18.75Single5WIUNemonapride5WIU-D4-Nemonapride
18.75Single5WIVNemonapride5WIV-D4-Nemonapride-Na
18.75Single5WQCEMPA5WQC-OX2-EMPA
18.75Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
18.75Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
18.75Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
18.75Single6PS6Timolol6PS6-β2-Timolol
18.75Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
18.75Single6TP6Filorexant6TP6-OX1-Filorexant
18.75Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
18.75Single6Z4SSR486926Z4S-NTS1-SR48692
18.75Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
18.75Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
18.75Single7SINNPS-21437SIN-CaS-NPS-2143
18.75Single7SINNPS-21437SIN-CaS-NPS-2143
18.75Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
18.75Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
18.75Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
18.75Single8XYKVUF106618XYK-CXCR3-VUF10661-Go/β1/γ2
18.75Single8ZMFA1L108ZMF-5-HT2C-A1L10
18.75Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
18.75Single9DYDAsenapine9DYD-5-HT1A-Asenapine-Go/β1/γ2
18.75Single9DYFAsenapine9DYF-5-HT1A-Asenapine-Gi1/β1/γ2
18.75Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
18.75Single9F33FOB02-04A9F33-D3-FOB02-04A-Go/β1/γ2
18.75Single9F34FOB02-04A9F34-D3-FOB02-04A-Go/β1/γ2
18.75Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
18.75Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
18.75Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
18.75Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
18.75Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
18.75Consensustrace-amine_onOrthosteric Ligandta1_on
18.52Single5GLHEndothelin-15GLH-ETB-Endothelin-1
18.52Single6IGKEndothelin-36IGK-ETB-Endothelin-3
18.52Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
18.52Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
18.18Single5WF5UK-4320975WF5-A2A-UK-432097
18.18Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
18.18Single6TQ9SB-4081246TQ9-OX1-SB-408124
18.18Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
18.18Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
18.18Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
18.18Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.18Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
18.18Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
18.18Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.18Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
18.18Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
18.18Single8W8YGamma-MSH8W8Y-MC3-γ-MSH-Ca-Gs/β1/γ2
18.18Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
18.18Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
18.18Single9CHUNoradrenaline9CHU-β2-Noradrenaline
18.18Single9EE9Adenosine9EE9-A2A-Adenosine-Gs/β1/γ2
18.18Single9M1OMorphine-Modulating Neuropeptide B9M1O-NPFF2-Morphine-Modulating Neuropeptide B-Gi1/β1/γ2
18.18Single9U4WGonadoliberin-19U4W-GnRH1-Gonadoliberin-1-chim(NtGi1L-Gs-CtGq)/β1/γ2
18.18Consensusangiotensin_onOrthosteric Ligandat1_on
18.18Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
18.18Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
18.18Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
18.18Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
18.18Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
18.18Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
18.18Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
18.18Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
18.18Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
18.18Consensussensory_onOrthosteric Ligandopsins_on
17.86Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
17.86Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
17.86Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
17.65Single4DJHJDTic4DJH-κ-JDTic
17.65Single4U15Tiotropium4U15-M3-Tiotropium
17.65Single5XR8AM8415XR8-CB1-AM841
17.65Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
17.65Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
17.65Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
17.65Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
17.65Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
17.65Single6OL9Tiotropium6OL9-M5-Tiotropium
17.65Single6TQ7SB-3348676TQ7-OX1-SB-334867
17.65Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
17.65Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
17.65Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
17.65Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
17.65Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
17.65Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
17.65Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
17.65Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
17.65Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
17.65Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.65Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
17.65Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
17.65Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
17.65Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
17.65Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
17.65Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
17.65Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
17.65Single9EGOYVF9EGO-CB1-YVF-Gi1/β1/γ2
17.65Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
17.65Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
17.65Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
17.65Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
17.65Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
17.65Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
17.65Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
17.65Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
17.65Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
17.65Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
17.65Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
17.65Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
17.65Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
17.39Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
17.39Single6JODAngiotensin II6JOD-AT2-Angiotensin II
17.39Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
17.39Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
17.39Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
17.39Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
17.39Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
17.39Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
17.39Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
17.39Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
17.39Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
17.39Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
17.39Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
17.39Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
17.39Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
17.39Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
17.39Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
17.39Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
17.39Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
17.39Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
17.39Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
17.39Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
17.24Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
16.67Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
16.67Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
16.67Single3PQRAll-trans-Retinal3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
16.67Single5CXVTiotropium5CXV-M1-Tiotropium
16.67Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
16.67Single6A93Risperidone6A93-5-HT2A-Risperidone
16.67Single6CM4Risperidone6CM4-D2-Risperidone
16.67Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
16.67Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
16.67Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
16.67Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
16.67Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
16.67Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
16.67Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
16.67Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
16.67Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
16.67Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
16.67Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
16.67Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
16.67Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
16.67Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
16.67Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
16.67Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
16.67Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
16.67Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
16.67Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
16.67Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
16.67Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
16.67Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
16.67Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
16.67Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
16.67Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
16.67Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
16.67Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
16.67Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
16.67Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
16.67Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
16.67Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
16.67Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
16.67Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
16.67Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
16.67Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
16.67Single8XYIVUF106618XYI-CXCR3-VUF10661
16.67Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
16.67Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
16.67Single8ZRTET-18ZRT-ETB-ET-1
16.67Single9DGIZ85267113509DGI-CB1-Z8526711350
16.67Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
16.67Single9JFYhNPSF9JFY-NPFF2-hNPSF-Gi1/β1/γ2
16.67Single9JHJC18:0 Ceramide9JHJ-FPR2-ALX-C18:0 Ceramide-Gi1/β1/γ2
16.67Single9LRCHistamine9LRC-H4-Histamine
16.67Single9LREHistamine9LRE-H4-Histamine-Gi1/β1/γ2
16.67Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
16.67Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
16.67Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
16.67Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
16.67Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
16.67Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
16.67Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
16.67Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
16.67Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
16.67Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
16.67Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
16.67Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
16.67Consensusgi_sensoryOrthosteric Ligandgi_opsins
16.67Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
16.67Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
16.67Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
16.67Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
16.67Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
16.67Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
16.67Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
16.67Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
16.67Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
16.67Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
16.67Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
16.67Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
16.67Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
16.00Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
16.00Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
16.00Single9KFKRelaxin-39KFK-RXFP4-Relaxin-3-Gi2/β1/γ2
16.00Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
16.00Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
16.00Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
16.00Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
16.00Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
15.79Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
15.79Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
15.79Single6K1QIRL25006K1Q-ETB-IRL2500
15.79Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
15.79Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
15.79Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
15.79Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
15.79Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
15.79Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
15.79Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
15.79Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
15.79Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
15.79Single8JPFNeurotensin8JPF-NTS1-Neurotensin-SBI-553
15.79Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
15.79Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
15.79Single8XVJMacitentan8XVJ-ETA-Macitentan
15.79Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
15.79Single9JH5C16:0 Ceramide9JH5-CysLT2-C16:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
15.79Single9M54Neuropeptide VF9M54-NPFF2-Neuropeptide VF-Gi1/β1/γ2
15.79Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
15.79Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
15.79Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
15.79Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
15.79Consensuschemerin_onOrthosteric Ligandcml1_on
15.79Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
15.62Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
15.62Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
15.38Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
15.38Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
15.38Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
15.38Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
15.38Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
15.38Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
15.38Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
15.38Single7UL2SR486927UL2-NTS1-SR48692-Na
15.38Single7V68Iperoxo7V68-M4-Iperoxo-LY2119620-Gi1/β1/γ2
15.38Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
15.38Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
15.38Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
15.38Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
15.38Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.38Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
15.38Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
15.38Single8W8XBeta-MSH8W8X-MC3-β-MSH-Ca-Gs/β1/γ2
15.38Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
15.38Single8YN2Histamine8YN2-H1-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.38Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
15.38Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
15.38Single8YN7Immethridine8YN7-H3-Immethridine-Go/β1/γ2
15.38Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
15.38Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
15.38Single9AS2DMT9AS2-5-HT2A-DMT-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Single9AS7Psilocin9AS7-5-HT2A-Psilocin
15.38Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
15.38Single9EPRRetinal9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
15.38Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg4_on
15.38Consensusadgrg_on_gpOrthosteric Ligandadgrg2_on_gp adgrg4_on_gp
15.38Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
15.38Consensusneurotensin_offOrthosteric Ligandnts1_off
15.38Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
15.38Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
15.38Consensusnts1_offOrthosteric Ligand7UL2-NTS1-SR48692-Na
15.38Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
15.15Consensuspth2_on_gpOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
15.00Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
15.00Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
15.00Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
15.00Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
15.00Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
15.00Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
15.00Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
15.00Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
15.00Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
15.00Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.00Single7SK9CCX6627SK9-ACKR3-CCX662
15.00Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
15.00Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
15.00Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
15.00Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
15.00Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
15.00Single8XQJJN2418XQJ-Apelin-JN241
15.00Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
15.00Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
15.00Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
15.00Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
15.00Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
14.81Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
14.29Single4S0VSuvorexant4S0V-OX2-Suvorexant
14.29Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
14.29Single5ZKQABT-4915ZKQ-PAF-ABT-491
14.29Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
14.29Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
14.29Single6TPJSuvorexant6TPJ-OX2-Suvorexant
14.29Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
14.29Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
14.29Single7F8XNN90567F8X-CCKA-NN9056
14.29Single7F8YDevazepide7F8Y-CCKA-Devazepide
14.29Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
14.29Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
14.29Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
14.29Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
14.29Single7QA8Peptide7QA8-STE2-Peptide
14.29Single7QA8Peptide7QA8-STE2-Peptide
14.29Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
14.29Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
14.29Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
14.29Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
14.29Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
14.29Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
14.29Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
14.29Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
14.29Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
14.29Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
14.29Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
14.29Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
14.29Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
14.29Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
14.29Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
14.29Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
14.29Single8IEIA1LYA8IEI-GPR156-A1LYA
14.29Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
14.29Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
14.29Single8IWESpermidine8IWE-TA9-Spermidine
14.29Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
14.29Single8KIGSHU91198KIG-MC3-SHU9119-Ca
14.29Single8PKMBefiradol8PKM-5-HT1A-Befiradol-Gi1/β1/γ1
14.29Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
14.29Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
14.29Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
14.29Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
14.29Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
14.29Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
14.29Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ2
14.29Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
14.29Single8ZBJSomatostatin-148ZBJ-SST5-Somatostatin-14-Gi1/β1/γ2
14.29Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
14.29Single9HB3Mambaquaretin-19HB3-V2-Mambaquaretin-1
14.29Single9K6LSA09K6L-TAS2R16-SA0-Gi2/β1/γ2
14.29Single9KPESA09KPE-TAS2R16-SA0-Gi1/β1/γ2
14.29Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
14.29Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
14.29Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
14.29Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
14.29Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
14.29Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
14.29Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
14.29Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
14.29Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
14.29Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
14.29Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
14.29Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
14.29Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
14.29Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
13.79Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
13.64Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
13.64Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
13.64Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
13.64Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
13.64Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
13.64Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
13.64Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
13.64Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
13.64Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
13.64Single9E82SDF-1-beta9E82-ACKR3-SDF-1-β-Arrestin2
13.64Single9IQRMuscarinic toxin 39IQR-α2a-Muscarinic toxin 3
13.64Single9IQSMuscarinic toxin 39IQS-M4-Muscarinic toxin 3
13.64Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
13.64Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
13.33Single2YDOAdenosine2YDO-A2A-Adenosine
13.33Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
13.33Single6TP3Nemorexant6TP3-OX1-Nemorexant
13.33Single6V9SGTPL114036V9S-OX1-GTPL11403
13.33Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
13.33Single6ZINSR486926ZIN-NTS1-SR48692
13.33Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
13.33Single7F61PF-036547467F61-H3-PF-03654746
13.33Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
13.33Single7T94Acetylcholine7T94-M2-Acetylcholine-LY2119620-chim(NtGi1-Go)/β1/γ2
13.33Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
13.33Single7UTZDPPC7UTZ-TSH-TR1402-DPPC-Gs/β1/γ2
13.33Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
13.33Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
13.33Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
13.33Single8IYXYL-3658IYX-GPR34-YL-365
13.33Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
13.33Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
13.33Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
13.33Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
13.33Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
13.33Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
13.33Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
13.33Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
13.33Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.33Single8Y6YGLPG09748Y6Y-FFA2-GLPG0974
13.33Single8ZPNAMD31008ZPN-CXCR4-AMD3100
13.33Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
13.33Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
13.33Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
13.33Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
13.33Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
13.33Single9JMDAzithromycin9JMD-Motilin-Azithromycin-chim(Gs-CtGq)/β1/γ2
13.33Single9KPDSA09KPD-TAS2R16-SA0-chim(Gs-CtGt3)/β1/γ2
13.33Single9M2FNeuropeptide FF9M2F-NPFF1-Neuropeptide FF-Gi1/β1/γ2
13.33Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
13.33Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
13.33Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
13.33Consensusopsins_offOrthosteric Ligandrhodopsin_off
13.33Consensussensory_offOrthosteric Ligandopsins_off
13.16Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
13.04Single3OE0CVX153OE0-CXCR4-CVX15
13.04Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
13.04Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
13.04Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
13.04Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
13.04Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
13.04Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
13.04Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
13.04Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
12.90Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
12.90Consensusclass-a_class-b1_cons_on_gpOrthosteric Ligandclass-a_on_gp class-b1_on_gp
12.90Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
12.50Single4DAJTiotropium4DAJ-M3-Tiotropium
12.50Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
12.50Single4MQSIperoxo4MQS-M2-Iperoxo
12.50Single4QIMANTA XV4QIM-SMO-ANTA XV
12.50Single4U14Tiotropium4U14-M3-Tiotropium
12.50Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
12.50Single5DHGC-355DHG-NOP-C-35
12.50Single5DHHSB-6121115DHH-NOP-SB-612111
12.50Single5DSGTiotropium5DSG-M4-Tiotropium
12.50Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
12.50Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
12.50Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
12.50Single6D27CAY104716D27-DP2-CAY10471
12.50Single6DRXLisuride6DRX-5-HT2B-Lisuride
12.50Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
12.50Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
12.50Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
12.50Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
12.50Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
12.50Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
12.50Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
12.50Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
12.50Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
12.50Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
12.50Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
12.50Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
12.50Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
12.50Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
12.50Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
12.50Single8T1WCVN4248T1W-GPR6-CVN424
12.50Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
12.50Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
12.50Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
12.50Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
12.50Single8YN8Proxyfan8YN8-H3-Proxyfan-Go/β1/γ2
12.50Single8ZYYNeurotensin peptide 8-138ZYY-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
12.50Single9AS1DMT9AS1-5-HT2A-DMT
12.50Single9JEAAtropine9JEA-M1-Atropine
12.50Single9JGKBalovaptan9JGK-5-HT2B-Balovaptan
12.50Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
12.50Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
12.50Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
12.50Consensusblt_onOrthosteric Ligandblt1_on
12.50Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
12.50Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
12.50Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
12.50Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
12.50Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
12.50Consensusleukotriene_onOrthosteric Ligandblt_on
12.50Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
12.50Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
12.50Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
12.50Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
12.50Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
12.50Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
12.50Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
12.00Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
12.00Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
12.00Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
12.00Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
12.00Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
12.00Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
12.00Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
12.00Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
12.00Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
11.76Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
11.76Single6D26Fevipiprant6D26-DP2-Fevipiprant
11.76Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
11.76Single6LUQHaloperidol6LUQ-D2-Haloperidol
11.76Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
11.76Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
11.76Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
11.76Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
11.76Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
11.76Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
11.76Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
11.76Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
11.76Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
11.76Single7W41PD1762527W41-BB2-PD176252
11.76Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.76Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
11.76Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
11.76Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
11.76Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
11.76Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
11.76Single8WGBVU01550418WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
11.76Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
11.76Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
11.76Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
11.76Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
11.76Single8ZYTNeurotensin peptide 8-138ZYT-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
11.76Single9ARZ2-bromo-LSD9ARZ-5-HT2A-2-bromo-LSD
11.76Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
11.76Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
11.76Single9KPFSA09KPF-TAS2R16-SA0-Gi1/β1/γ2
11.76Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
11.76Consensusbombesin_offOrthosteric Ligandbb2_off
11.76Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
11.76Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
11.76Consensusdp_offOrthosteric Liganddp2_off
11.76Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
11.76Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
11.76Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
11.76Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.76Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.76Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
11.76Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
11.54Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
11.54Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
11.54Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
11.54Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
11.54Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
11.54Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
11.54Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
11.54Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
11.11Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
11.11Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
11.11Single4BV0Neurotensin4BV0-NTS1-Neurotensin
11.11Single5V56TC1145V56-SMO-TC114
11.11Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
11.11Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
11.11Single6OS1TRV0266OS1-AT1-TRV026
11.11Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
11.11Single7B6WCyclazosin7B6W-α1b-Cyclazosin
11.11Single7F1TMIP-1a7F1T-CCR5-MIP-1a
11.11Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
11.11Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
11.11Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
11.11Single7R0CAVP7R0C-V2-AVP-Arrestin2
11.11Single7T9NDPPC7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
11.11Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
11.11Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
11.11Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
11.11Single8EA0Iperoxo8EA0-M3-Iperoxo
11.11Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
11.11Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
11.11Single8JD5JNJ-40411813; ADX881788JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
11.11Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
11.11Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
11.11Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
11.11Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
11.11Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
11.11Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
11.11Single9AS9RS130-1809AS9-5-HT2A-RS130-180
11.11Single9ASARS130-1809ASA-5-HT2A-RS130-180-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
11.11Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
11.11Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Consensusneurotensin_onOrthosteric Ligandnts1_on
11.11Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
11.11Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
11.11Consensusrelaxin_onOrthosteric Ligandrxfp4_on
11.11Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
10.71Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
10.71Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
10.71Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
10.71Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
10.71Consensuspth1_onOrthosteric Ligand6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
10.53Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
10.53Single4N4WSANT-14N4W-SMO-SANT-1
10.53Single4XEENeurotensin4XEE-NTS1-Neurotensin
10.53Single4XESNeurotensin4XES-NTS1-Neurotensin
10.53Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
10.53Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
10.53Single6ZG4HTL00099366ZG4-M1-HTL0009936
10.53Single7DFPSpiperone7DFP-D2-Spiperone
10.53Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
10.53Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
10.53Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
10.53Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
10.53Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
10.53Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
10.53Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
10.53Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
10.53Single8XQJJN2418XQJ-Apelin-JN241
10.53Single8XWACXCL18XWA-CXCR2-CXCL1
10.53Single8XWMCXCL68XWM-CXCR2-CXCL6
10.53Single8XWSCXCL58XWS-CXCR2-CXCL5
10.53Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
10.53Single9GL2Befiradol9GL2-5-HT1A-Befiradol-Gs/β1/γ2
10.53Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
10.53Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
10.53Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
10.53Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
10.53Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
10.53Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
10.53Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
10.34Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
10.34Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
10.34Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
10.34Consensusbombesin_onOrthosteric Ligandbb2_on
10.34Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
10.34Consensusclass-a_class-b1_cons_onOrthosteric Ligandclass-a_on class-b1_on
10.34Consensuscrf1_onOrthosteric Ligand6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF1-Corticoliberin-Gs/β1/γ2
10.34Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
10.00Single4BUONeurotensin4BUO-NTS1-Neurotensin
10.00Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
10.00Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
10.00Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
10.00Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
10.00Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-SBI-553-chim(NtGi1-Go)/β1/γ2
10.00Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/β1/γ2
10.00Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
10.00Single8XVUCXCL28XVU-CXCR2-CXCL2
10.00Single8XWFCXCL38XWF-CXCR2-CXCL3
10.00Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
10.00Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
10.00Single8ZPLHF511168ZPL-CXCR4-HF51116
10.00Single9AS02-bromo-LSD9AS0-5-HT2A-2-bromo-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Single9DYEBuspirone9DYE-5-HT1A-Buspirone-Go/β1/γ2
10.00Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
10.00Consensuscck_onOrthosteric Ligandccka_on cckb_on
10.00Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
10.00Consensusprostanoid_offOrthosteric Ligandep_off dp_off
9.68Consensuscrf1_on_gpOrthosteric Ligand6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF1-Corticoliberin-Gs/β1/γ2
9.68Consensuscrf_on_gpOrthosteric Ligandcrf2_on_gp crf1_on_gp
9.68Consensuspth1_on_gpOrthosteric Ligand6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
9.52Single6KNMJN241-96KNM-Apelin-JN241-9
9.52Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
9.52Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
9.52Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
9.52Single9MD1Buspirone9MD1-5-HT1A-Buspirone-Gz/β1/γ2
9.52Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
9.09Single4XT1Fractalkine4XT1-US28-Fractalkine
9.09Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
9.09Single7V68LY21196207V68-M4-Iperoxo-LY2119620-Gi1/β1/γ2
9.09Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single7XKDBeta-Hydroxyandrosterone7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
9.09Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
9.09Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
9.09Single8U4OCXCL128U4O-CXCR4-CXCL12-Gi1/β1/γ2
9.09Single8XWNCXCL88XWN-CXCR2-CXCL8
9.09Single8YWFRetatrutide8YWF-GLP-1-Retatrutide-chim(NtGi1-Gs)/β1/γ2
9.09Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
9.09Consensuspth_onOrthosteric Ligandpth1_on pth2_on
8.70Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
8.70Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
8.70Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
8.70Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
8.70Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
8.70Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
8.70Single9IQVMuscarinic toxin 39IQV-Alpha1A-Muscarinic toxin 3
8.70Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
8.70Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
8.33Single2HPYAll-trans-Retinal2HPY-Rhodopsin-All-trans-Retinal
8.33Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
8.33Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
8.33Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Single7Y14Beta-Alanine7Y14-MRGPRD-β-Alanine
8.33Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
8.33Single8WC5Tetramethylammonium Ion8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
8.33Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Single8Y02Retinal8Y02-OPN1SW-Retinal-Gi1/β1/γ2
8.33Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
8.33Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
8.33Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Consensusp2y_offOrthosteric Ligandp2y1_off
8.11Consensuspth_on_gpOrthosteric Ligandpth1_on_gp pth2_on_gp
8.00Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
8.00Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
8.00Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
8.00Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
8.00Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
8.00Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ2
8.00Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
7.69Single4XNWMRS25004XNW-P2Y1-MRS2500
7.69Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
7.69Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
7.69Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
7.69Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
7.69Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
7.69Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
7.69Single7Y12Beta-Alanine7Y12-MRGPRD-β-Alanine-Gi1/β1/γ2
7.69Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
7.69Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
7.69Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
7.69Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
7.69Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
7.69Single8WG8Peptide8WG8-Glucagon-Peptide-chim(NtGi1-Gs)/β1/γ2
7.69Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
7.69Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
7.69Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
7.69Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
7.69Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
7.69Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
7.69Consensusvpac_onOrthosteric Ligandvpac1_on vpac2_on
7.41Single4XT3Fractalkine4XT3-US28-Fractalkine
7.41Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
7.41Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
7.41Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
7.41Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
7.41Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
7.41Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
7.41Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
7.41Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
7.41Consensuspac_on_gpOrthosteric Ligandpac1_on_gp
7.41Consensusvpac_on_gpOrthosteric Ligandvpac1_on_gp vpac2_on_gp
7.14Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
7.14Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
7.14Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
7.14Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
7.14Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
7.14Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
7.14Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
7.14Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
7.14Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
7.14Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
7.14Single7XP6Strychnine7XP6-TAS2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
7.14Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
7.14Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
7.14Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
7.14Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab
7.14Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
7.14Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.14Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
7.14Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
7.14Single8ZYUNeurotensin peptide 8-138ZYU-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
7.14Single9B9Y7DY9B9Y-CB1-7DY
7.14Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
7.14Consensusglp_onOrthosteric Ligandglp1_on glp2_on
7.14Consensusglp_on_gpOrthosteric Ligandglp1_on_gp glp2_on_gp
7.14Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
6.90Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
6.90Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
6.90Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
6.90Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
6.90Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
6.90Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
6.90Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
6.90Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
6.90Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
6.90Single9BYOExendin-39BYO-GLP-1-Exendin-3-Gs/β1/γ2
6.90Consensusvip-pacap_onOrthosteric Ligandvpac_on pac_on
6.90Consensusvip-pacap_on_gpOrthosteric Ligandvpac_on_gp pac_on_gp
6.67Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
6.67Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
6.67Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
6.67Single4BWBNeurotensin4BWB-NTS1-Neurotensin
6.67Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
6.67Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
6.67Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
6.67Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
6.67Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.67Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
6.67Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
6.67Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
6.67Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
6.67Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
6.67Single8U4PAMD31008U4P-CXCR4-AMD3100-Gi1/β1/γ2
6.67Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
6.67Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
6.67Single8Y0HVUF114188Y0H-CXCR3-VUF11418
6.67Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go/β1/γ2
6.67Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
6.67Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
6.67Consensusangiotensin_offOrthosteric Ligandat1_off
6.67Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
6.67Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
6.67Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
6.67Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
6.67Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
6.67Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
6.67Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
6.45Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
6.45Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
6.45Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
6.45Consensusglp1_onOrthosteric Ligand7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
6.25Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
6.25Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
6.25Single6FFIMMPEP6FFI-mGlu5-MMPEP
6.25Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
6.25Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
6.25Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
6.25Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
6.25Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
6.25Single7T94LY21196207T94-M2-Acetylcholine-LY2119620-chim(NtGi1-Go)/β1/γ2
6.25Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
6.25Single7VODCariprazine7VOD-5-HT2A-Cariprazine
6.25Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
6.25Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
6.25Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
6.25Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
6.25Single8K2WAMG4878K2W-CXCR3-AMG487
6.25Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
6.25Single8YRGFospropofol8YRG-MRGPRX4-Fospropofol-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25Single8ZPMAMD0708ZPM-CXCR4-AMD070
6.25Single9BA0A1AKN9BA0-CB1-A1AKN
6.25Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
6.25Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
6.25Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
6.25Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
6.25Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
6.25Consensusglp1_on_gpOrthosteric Ligand7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
6.06Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
6.06Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
6.06Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
6.06Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
6.06Consensusglucagon_onOrthosteric Ligandglp_on gluc_on secretin_on gip_on
5.88Single4YAYZD-71554YAY-AT1-ZD-7155
5.88Single5TGZAM65385TGZ-CB1-AM6538
5.88Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
5.88Single6FFHFenobam6FFH-mGlu5-Fenobam
5.88Single6GPSMK08126GPS-CCR2-MK0812
5.88Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
5.88Single7F83PF-051904577F83-Ghrelin-PF-05190457
5.88Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
5.88Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
5.88Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
5.88Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
5.88Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
5.88Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
5.88Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
5.88Single8TH3AT118-H Nanobody8TH3-AT1-AT118-H Nanobody
5.88Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
5.88Single9IMATalquetamab9IMA-GPRC5D-Talquetamab
5.88Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
5.88Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
5.88Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
5.88Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
5.88Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
5.88Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
5.88Consensusgluc_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
5.88Consensusglucagon_on_gpOrthosteric Ligandglp_on_gp gluc_on_gp secretin_on_gp gip_on_gp
5.71Consensusgluc_on_gpOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
5.56Single4JKVTaladegib4JKV-SMO-Taladegib
5.56Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
5.56Single5CGCHTL142425CGC-mGlu5-HTL14242
5.56Single6GPXMK08126GPX-CCR2-MK0812
5.56Single7C4SS1P7C4S-S1P3-S1P
5.56Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
5.56Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
5.56Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
5.56Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
5.56Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
5.56Single9B9ZA1AKO9B9Z-CB1-A1AKO
5.56Single9HC04YI9HC0-mGlu5-4YI
5.56Consensusadgrg2_onOrthosteric Ligand7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
5.56Consensusadgrg2_on_gpOrthosteric Ligand7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
5.56Consensusclass-b1_onOrthosteric Ligandglucagon_on vip-pacap_on pth_on crf_on calcitonin_on
5.56Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
5.26Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
5.26Single5V57TC1145V57-SMO-TC114
5.26Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
5.26Single7P2L4YI7P2L-mGlu5-4YI
5.26Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
5.26Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.26Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.26Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
5.26Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
5.26Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
5.26Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Gi1/β1/γ1
5.26Single8YNTSNAP-948478YNT-MCH1-SNAP-94847
5.00Single6OS2TRV0266OS2-AT1-TRV026
5.00Single6YVRNTS8-136YVR-NTS1-NTS8-13
5.00Single7K15MKD0467K15-BLT1-MKD046-Na
5.00Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
5.00Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.00Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
5.00Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
5.00Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
5.00Consensusclass-b1_on_gpOrthosteric Ligandglucagon_on_gp vip-pacap_on_gp pth_on_gp crf_on_gp calcitonin_on_gp
5.00Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
5.00Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
4.76Single5CGDHTL142425CGD-mGlu5-HTL14242
4.76Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
4.76Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
4.76Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
4.76Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
4.76Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Single9C0KExendin-49C0K-GLP-1-Exendin-4-Gs/β1/γ2
4.76Consensusfp-alpha_onOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.76Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.55Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
4.55Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
4.55Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
4.55Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
4.55Single9IZASCH9002719IZA-HCA2-SCH900271-Gi1/β1/γ2
4.55Single9JF4PD1683689JF4-BB1-PD168368
4.55Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
4.35Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
4.35Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
4.35Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
4.35Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
4.35Consensussomatostatin_offOrthosteric Ligandsst2_off
4.17Single7SK5CXCL127SK5-ACKR3-CXCL12
4.17Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
4.17Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
4.17Single7XNACYN1548067XNA-SST2-CYN154806
4.17Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
4.00Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
4.00Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
4.00Single9B5YLong-Acting PTH9B5Y-PTH1-Long-Acting PTH-chim(NtGi1-Gq)/β1/γ2
4.00Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
4.00Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
4.00Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
4.00Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
4.00Consensusclass-b1_class-b2_cons_onOrthosteric Ligandclass-b1_on class-b2_on
4.00Consensusclass-b1_class-b2_cons_on_gpOrthosteric Ligandclass-b1_on_gp class-b2_on_gp
3.85Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
3.85Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
3.85Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
3.85Single9EBOGLP-1 (ACPC18)9EBO-GLP-1-GLP-1 (ACPC18)-Gs/β1/γ2
3.85Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
3.70Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
3.70Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
3.70Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
3.70Consensuspac_onOrthosteric Ligandpac1_on
3.70Consensusvpac1_onOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
3.57Single6FJ3PTH6FJ3-PTH1-PTH
3.57Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
3.57Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
3.57Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
3.57Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
3.57Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
3.57Single7SK3CXCL127SK3-ACKR3-CXCL12
3.57Single9BLBCagrilintide backbone (non-acylated)9BLB-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
3.57Single9BLWCagrilintide backbone (non-acylated)9BLW-CT (AMY1)-Cagrilintide backbone (non-acylated)-Gs/β1/γ2; RAMP1
3.57Consensuscrf2_on_gpOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
3.57Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
3.57Consensuspac1_onOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
3.57Consensuspac1_on_gpOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
3.57Consensussecretin_onOrthosteric Ligand7D3S-Secretin-Secretin-Gs/β1/γ2
3.57Consensusvpac1_on_gpOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
3.45Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
3.45Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
3.45Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
3.45Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
3.45Single9BUCCagrilintide9BUC-CT-Cagrilintide-Gs/β1/γ2
3.45Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
3.45Consensusglp2_on_gpOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
3.45Consensussecretin_on_gpOrthosteric Ligand7D3S-Secretin-Secretin-Gs/β1/γ2
3.33Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
3.33Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
3.33Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
3.33Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
3.33Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
3.33Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
3.33Consensusctlike_on_gpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
3.33Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
3.33Consensusvpac2_on_gpOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
3.23Single7RBTTirzepatide7RBT-GIP-Tirzepatide-LSN3556672-chim(NtGi1-Gs)/β1/γ2
3.23Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
3.23Consensusgip_onOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
3.23Consensusgip_on_gpOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
3.12Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
2.94Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
2.94Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2

Consensus Members
Id Members
8J21 8J21-FFA3-Butyric acid-Gi1/β1/γ2
Net Summary
Imin 2.77
Number of Linked Nodes 839
Number of Links 1033
Number of Hubs 180
Number of Links mediated by Hubs 636
Number of Communities 31
Number of Nodes involved in Communities 263
Number of Links involved in Communities 379
Path Summary
Number Of Nodes in MetaPath 127
Number Of Links MetaPath 126
Number of Shortest Paths 1965373
Length Of Smallest Path 3
Average Path Length 34.0298
Length of Longest Path 58
Minimum Path Strength 1.07
Average Path Strength 6.25764
Maximum Path Strength 21.79
Minimum Path Correlation 0.7
Average Path Correlation 0.986244
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.43902
Average % Of Corr. Nodes 46.3816
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 53.7647
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following consensuses:
IdComponents
ffa_on_gpffa2_on_gp
ffa3_on_gp



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