Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
1Lig 8.123212120
21x36 1.59125405
31x39 4.505507
42x40 3.39656408
52x42 5.09292637
62x46 3.83313439
72x50 5.16354639
82x53 7.0625526
92x57 4.56325507
10E1x50 7.84125628
11E1x52 6.74025506
123x32 5.43563426
133x36 6.26781427
143x37 3.89021606
153x50 6.018539
163x51 6.0655108
174x38 2.49708606
18E2 7.551882023
19E2x50 5.82844429
205x36 3.51437424
215x39 3.82375627
225x40 2.99219425
235x42 2.91125424
245x43 3.145524
255x47 4.65775528
265x50 2.57812409
275x51 2.50437406
285x58 5.36958639
29I3 3.33333673
306x26 3.33344474
316x30 5.41375476
326x40 4.63687438
336x48 7.02042608
346x49 3.29344405
356x51 5.88675526
366x52 5.03625527
376x54 2.5915524
386x59 2.66969404
39E3 4.10575522
407x35 4.58844402
417x38 3.11313426
427x39 4.30687405
437x42 7.30275527
447x49 4.35167639
457x50 3.02525539
467x52 2.52938438
477x53 4.89771639
488x47 1.66469408
498x50 2.5475708
50G.S1.02 4.56969465
51G.S1.06 3.5425568
52G.H1.01 3.8375469
53G.H1.08 3.15063468
54G.S3.01 4.18687464
55G.S3.03 6.32271667
56G.S3.04 6.98188416
57G.S3.05 3.64312467
58G.S3.06 7.072515
59G.S3.07 3.24125469
60G.H2.04 3.43719409
61G.H2.06 4.73542619
62G.H2.07 4.40813619
63G.h2s4.01 5.92025519
64G.S4.02 3.50469418
65G.s4h3.04 4.738577168
66G.H3.01 2.72225509
67G.H3.06 3.14031416
68G.H3.09 4.80208619
69G.H3.13 3.8085515
70G.H3.17 7.06146615
71G.H3.18 4.95344419
72G.S5.03 3.144578
73G.S5.04 3.08156419
74G.S5.05 3.77675579
75G.S5.07 3.64031409
76G.HG.02 2.15531409
77G.HG.04 4.30969409
78G.HG.14 2.1625405
79G.hgh4.02 4.20196717
80G.hgh4.05 7.33406407
81G.H4.05 3.05625404
82G.H4.08 1.36563403
83G.H4.12 5.52406415
84G.H4.15 3.80675518
85G.S6.02 5.185877
86G.H5.08 4.2495568
87G.H5.09 4.05094404
88G.H5.26 4.04675505
89b.1x4 1.60656408
90b.1x11 1.5015508
91b.lh12x2 3.07781408
92b.h2x5 3.31281405
93b.lhb1x11 2.93656484
94b.b1x4 3.13281447
95b.l1x3 7.41313649
96b.l1x6 6.98025519
97b.b2x1 6.4865518
98b.b2x5 6.30104647
99b.l3x1 6.32719419
100b.l3x2 4.35775549
101b.b4x4 7.93563448
102b.b4x5 3.843754117
103b.b4x6 8.07911749
104b.l4x2 9.24719444
105b.b5x2 5.40656407
106b.b5x3 5.88688649
107b.b5x5 4.741254115
108b.b5x7 5.744064117
109b.l5x1 4.16344408
110b.l5x5 7.27396619
111b.b6x5 3.29521606
112b.l6x5 5.679694134
113b.b7x1 5.610634134
114b.b8x3 3.06188406
115b.b8x4 4.262296116
116b.l8x5 5.713134143
117b.l8x8 4.771884114
118b.l9x3 5.99417619
119b.l9x6 4.61982718
120b.l9x7 3.00725517
121b.b10x5 3.82083609
122b.b11x4 4.31375419
123b.b11x6 6.88062419
124b.l11x2 5.60063619
125b.b12x6 7.07304718
126b.b13x7 6.744597
127b.l13x3 6.47917699
128b.b14x1 4.39469418
129b.b14x3 3.61225595
130b.b15x1 5.825599
131b.b15x2 5.90875456
132b.l15x2 4.97175599
133b.b16x4 7.60575596
134b.b16x5 3.581505
135b.b16x6 8.15646698
136b.b17x4 4.935314155
137b.b17x7 5.408558
138b.l17x3 8.24833659
139b.b18x3 4.403558
140b.b18x5 4.94531455
141b.l18x1 5.505897126
142b.l18x2 5.040314127
143b.l18x3 6.576564125
144b.b19x2 5.66196756
145b.b19x4 5.52719458
146b.l19x2 6.28275559
147b.b20x4 9.12075558
148b.b20x6 6.8715556
149b.l20x2 4.32469409
150b.b21x1 5.65975557
151b.b21x5 3.8845514
152b.b21x7 5.33458615
153b.b22x5 4.490836127
154b.l22x5 7.05754179
155b.b23x1 2.95469485
156b.b23x6 5.95946717
157b.l23x1 6.12281416
158b.b24x4 6.47281416
159b.b24x6 6.29844418
160b.b24x7 6.559064179
161b.l24x2 4.261884176
162b.l24x3 3.53281405
163b.b25x3 5.87375415
164b.l25x3 7.655589
165b.l25x6 10.6119418
166b.b26x3 3.07094406
167b.l27x1 9.95719
168b.l27x2 7.55062489
169b.b28x3 3.29325547
170b.b28x4 5.728586
171b.b28x6 9.1055589
172b.b28x7 5.40281409
173g.h1x4 1.93906405
174g.h2x11 6.806254126
175g.ctx3 5.2975409
176g.ctx16 3.61479648
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
13x36 Lig 19.49958.18875YesYes270
22x50 7x46 11.23217.36YesNo098
32x53 7x46 10.96734.2475YesNo068
47x45 7x49 36.03115.79NoYes099
56x48 7x45 35.233211.0175YesNo089
63x36 6x48 24.81876.65875YesYes078
72x42 3x46 14.40695.64375YesNo379
87x49 7x53 53.37243.19875YesYes399
9G.H3.17 b.l25x6 17.53224.125YesYes158
10G.H3.15 G.H3.17 18.91932.68375NoYes185
11G.H3.15 G.H3.18 19.00875.49125NoYes189
12G.H3.18 G.S4.02 19.21225.56YesYes198
13G.S4.02 G.S5.02 22.01222.575YesNo186
14G.H3.09 G.S5.02 22.05433.4725YesNo196
15G.H3.09 G.H4.15 36.98674.42125YesYes198
16G.H3.06 G.H4.15 63.34794.4775YesYes168
17G.H3.06 G.hgh4.02 67.22172.54625YesYes167
18G.HG.15 G.hgh4.02 33.5092.5425NoYes077
19G.HG.15 G.hgh4.05 33.72733.1925NoYes077
20G.H4.05 G.hgh4.05 1003.62125YesYes047
21G.H4.04 G.H4.05 99.71252.55125NoYes044
22G.H4.03 G.H4.04 99.66253.705NoNo044
23G.H4.03 G.HG.01 99.56245.22625NoNo045
24G.HG.01 G.s6h5.02 99.51245.24375NoNo057
25G.HG.02 G.s6h5.02 99.46232.91625YesNo097
26G.HG.02 G.HG.03 99.26172.71625YesNo096
27G.HG.03 G.s4h3.02 49.14173.94125NoNo069
28G.S5.07 G.s4h3.02 49.08342.6075YesNo099
29G.S5.07 G.s6h5.01 97.90345.30125YesNo099
30G.S5.05 G.s6h5.01 96.52826.9725YesNo099
31G.S5.03 G.S5.05 50.00092.82625YesYes789
32G.S5.03 G.S6.02 46.0943.62875YesYes787
33G.H5.13 G.S6.02 83.80088.335NoYes087
34G.H5.13 G.H5.17 83.29478.1225NoNo085
35G.H5.17 G.H5.26 82.78872.945NoYes055
36G.H5.20 G.H5.26 80.71164.11125NoYes095
37G.H5.20 G.H5.25 79.9212.595NoNo097
383x50 G.H5.25 79.65747.895YesNo097
393x50 7x53 57.99435.27375YesYes399
40G.H3.09 G.h4s6.01 36.78943.52625YesNo094
41G.H3.06 G.h4s6.01 36.97123.00875YesNo064
42G.H4.10 G.hgh4.02 33.24996.01625NoYes167
43G.H4.10 G.hgh4.05 66.340518.54NoYes067
44G.H3.06 G.H4.14 33.12432.52875YesNo165
45G.H4.10 G.H4.14 33.11879.3725NoNo165
46G.HG.03 G.s5hg.01 50.07013.1725NoNo069
47G.S5.07 G.s5hg.01 49.19494.72125YesNo099
48G.H5.06 G.S5.05 46.15472.41375NoYes739
49G.H5.06 G.S6.02 46.02932.44875NoYes737
50G.H3.09 G.S4.04 51.31259.91375YesNo199
51G.H3.08 G.S4.04 76.96314.24NoNo099
52G.H2.04 G.H3.08 76.82595.12875YesNo099
53G.H2.04 G.H2.07 76.42835.125YesYes099
54G.H2.07 b.l9x6 75.71873.61875YesYes198
55b.b14x1 b.l9x6 26.86613.8925YesYes188
56b.b10x1 b.b14x1 27.10372.68375NoYes098
57b.b10x1 b.b11x5 26.9512.64875NoNo096
58b.b11x5 b.b14x3 22.48294.6925NoYes065
59b.b10x2 b.b14x3 19.49014.76125NoYes065
60b.b10x2 b.b10x4 19.25173.135NoNo066
61b.b10x4 b.b2x4 18.184513.5413NoNo066
62b.b2x4 b.b6x5 18.04242.725NoYes066
63G.H4.15 G.S5.04 26.47942.89375YesYes189
64G.S4.04 G.S5.04 25.79573.19625NoYes199
65G.H2.06 b.l9x6 40.05263.1325YesYes198
66G.H2.06 b.b18x1 39.98853.325YesNo099
67b.b18x1 b.l19x1 39.8377.74125NoNo099
68b.l17x5 b.l19x1 39.68553.1275NoNo069
69b.l17x5 b.l19x2 39.5345.52125NoYes069
70b.l17x3 b.l19x2 30.69664.2525YesYes599
71b.b19x4 b.l17x3 22.01568.55625YesYes589
72b.b19x2 b.b19x4 12.08922.7525YesYes568
73b.b17x7 b.b21x1 27.98332.68625YesYes587
74b.1x19 b.b21x1 23.66796.55NoYes067
75b.1x15 b.1x19 19.96223.7575NoNo076
76b.1x15 g.h1x14 18.72682.2525NoNo079
77g.h1x10 g.h1x14 18.10913.345NoNo099
78b.1x11 g.h1x10 16.87351.21125YesNo089
79b.1x11 g.h1x11 13.78441.73625YesNo089
80g.h1x11 g.h1x7 12.54842.1425NoNo092
81b.1x5 g.h1x7 11.93041.0625NoNo032
82b.b17x7 b.b20x6 22.37268.44YesYes586
83b.b20x4 b.b20x6 15.22383.74125YesYes586
842x50 7x49 12.80385.89125YesYes399
853x46 3x50 14.54824.88125NoYes399
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
E2Lig4.746252YesYes3010
5x36Lig6.491252YesYes4010
E3Lig3.12252YesYes2010
6x54Lig2.593752YesYes4010
7x34Lig14.29252NoYes4010
E2x51Lig10.6852NoYes4010
E2x52Lig4.031252NoYes5010
5x39Lig3.178752YesYes7010
5x40Lig2.78752YesYes5010
3x36Lig8.188752YesYes7010
5x43Lig4.40252YesYes4010
6x51Lig9.616252YesYes6010
3x32Lig8.088752YesYes6010
7x38Lig3.4652YesYes6010
7x42Lig4.523752YesYes7010
2x63Lig5.608752NoYes5010
7x31Lig2.8050NoYes3010
2x533x325.743752YesYes6621
2x533x365.483752YesYes6721
2x537x4215.20872YesYes6721
2x577x428.181250YesYes7721
2x63E1x507.293752NoYes5812
2x63E23.40252NoYes5311
E1x49E26.5952NoYes4321
3x25E1x507.346252NoYes9822
E1x50E25.10752YesYes8321
E1x50E2x5011.59122YesYes8922
3x25E23.666252NoYes9321
3x25E2x506.8252NoYes9922
3x327x425.603752YesYes6711
3x363x374.742YesYes7612
3x366x486.658752YesYes7812
3x375x432.7550YesYes6421
4x61E2x523.066250NoNo3521
4x615x394.66750NoYes3721
4x64E214.3352NoYes4321
4x65E22.670NoYes4321
E2E231.24872YesYes3311
E2E2x502.471252YesYes3912
E2E2x512.98752YesNo3411
E2E2x525.053752YesNo3511
5x35E213.782NoYes3321
5x36E24.513752YesYes4311
5x39E27.016252YesYes7311
5x325x352.956252NoNo2322
5x366x592.55252YesYes4412
5x395x422.70752YesYes7412
5x406x553.36752YesNo5611
5x406x594.486252YesYes5412
5x436x522.503752YesYes4712
6x486x522.563750YesYes8722
6x487x417.643750YesNo8722
6x516x5510.08252YesNo6611
6x517x382.528752YesYes6611
6x547x343.4152YesNo4411
6x58E32.59750NoYes4221
E3E36.646252YesYes2211
7x347x383.46252NoYes4611
2x60Lig6.1850NoYes6010
3x22E23.276250NoYes3321
5x32E22.473752NoYes2321
6x516x523.923752YesYes6712
6x517x413.28252YesNo6712
6x547x373.423752YesNo4712
6x55Lig6.522NoYes6010
7x387x422.996252YesYes6711
3x26E23.286250NoYes6321
5x395x433.566252YesYes7411
5x425x432.49752YesYes4421
3x323x332.306252YesNo6412
E1E21.93250NoYes4321
6x546x571.878752YesNo4412
4x605x391.806250NoYes8721
6x547x331.646252YesNo4412
7x30E31.516252NoYes4221
5x406x561.32752YesNo5512
5x31E21.226250NoYes0321
5x345x360.50NoYes1421

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
90.00Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
90.00Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
85.71Single8ZBISomatostatin-148ZBI-SST3-Somatostatin-14-Gi1/β1/γ2
75.00Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
75.00Single7XN9L-054,5227XN9-SST2-L-054,522
75.00Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
75.00Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
73.91Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
71.43Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
69.57Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
68.42Single9IK9SST analogue9IK9-SST1-SST analogue-Gi1/β1/γ2
68.18Single9IK8SST analogue9IK8-SST1-SST analogue-Gi1/β1/γ2
66.67Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
66.67Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
65.22Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
63.64Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
63.64Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
63.64Single8ZBJSomatostatin-148ZBJ-SST5-Somatostatin-14-Gi1/β1/γ2
63.64Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
63.64Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
61.54Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
60.87Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
60.87Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
60.87Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
60.87Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
58.33Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
57.89Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
57.69Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
57.14Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
57.14Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
57.14Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
57.14Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
57.14Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
56.52Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
56.00Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
56.00Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
56.00Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
56.00Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
55.56Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
55.56Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
55.56Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
55.56Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
55.00Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
54.55Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
54.55Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
54.17Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
54.17Single9IQVMuscarinic toxin 39IQV-Alpha1A-Muscarinic toxin 3
53.85Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
53.85Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
53.85Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
53.85Single9JFYhNPSF9JFY-NPFF2-hNPSF-Gi1/β1/γ2
53.57Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
53.57Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
53.57Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
53.57Consensusbradykinin_onOrthosteric Ligandbk2_on
53.57Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
53.57Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
52.63Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
52.63Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
52.38Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
52.38Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
52.38Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
52.38Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
52.38Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
52.38Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
52.38Consensusrelaxin_onOrthosteric Ligandrxfp4_on
52.38Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
52.17Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
52.17Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
52.17Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
52.17Single9M0RNeuropeptide VF9M0R-NPFF1-Neuropeptide VF-Gi1/β1/γ2
52.00Single6PT2KGCHM076PT2-δ-KGCHM07
52.00Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
52.00Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
52.00Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
52.00Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
52.00Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
51.85Single9KFKRelaxin-39KFK-RXFP4-Relaxin-3-Gi2/β1/γ2
51.85Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
51.85Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
51.85Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
51.85Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
51.61Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
50.00Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
50.00Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
50.00Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
50.00Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
50.00Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
50.00Single8WDTphotoNECA8WDT-A2A-photoNECA
50.00Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
50.00Single9BUYLM1899BUY-β2-LM189-Gi1/β1/γ2
50.00Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
50.00Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
50.00Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
50.00Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
50.00Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
50.00Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
50.00Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
48.28Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
48.15Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
48.15Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
48.15Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
48.15Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
48.00Single3QAKUK-4320973QAK-A2A-UK-432097
48.00Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
48.00Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
48.00Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
48.00Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
48.00Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
48.00Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
48.00Single9KFIRelaxin-39KFI-RXFP3-Relaxin-3-Gi2/β1/γ2
48.00Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
48.00Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
47.83Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
47.83Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
47.83Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
47.62Single5N2SPSB365N2S-A1-PSB36
47.62Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
47.62Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
47.62Single7LD3Adenosine7LD3-A1-Adenosine-MIPS521-Gi2/β1/γ2
47.62Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
47.62Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
47.37Single8GNGIstradefylline8GNG-A2A-Istradefylline
47.37Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
47.37Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
47.37Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
47.37Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
46.67Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
46.43Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
46.43Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
46.43Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
46.43Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
46.15Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
46.15Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
46.15Consensusangiotensin_onOrthosteric Ligandat1_on
46.15Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
45.83Single3NY9ICI118-5513NY9-β2-ICI118-551
45.83Single4UG2CGS216804UG2-A2A-CGS21680
45.83Single5WF6UK-4320975WF6-A2A-UK-432097
45.83Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
45.83Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
45.83Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
45.83Single8QJ2pN1628QJ2-MC4-pN162-Gs
45.83Single9V2NMacimorelin9V2N-Ghrelin-Macimorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
45.83Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
45.83Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
45.83Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
45.83Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
45.83Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
45.45Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
45.45Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
45.45Single6J21Aprepitant6J21-NK1-Aprepitant
45.45Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
45.45Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
45.45Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
45.45Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
45.45Consensusa2_onOrthosteric Liganda2b_on
45.45Consensusa2_on_gpOrthosteric Liganda2b_on_gp
45.45Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
45.45Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
45.45Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
45.45Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
45.45Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
45.45Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
45.00Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
45.00Single6MH8ZM-2413856MH8-A2A-ZM-241385
45.00Single7AROLUF58337ARO-A2A-LUF5833-Na
45.00Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
45.00Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
45.00Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
45.00Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
44.83Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
44.83Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
44.44Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
44.44Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
44.44Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
44.44Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
44.44Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
44.44Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
44.44Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
44.44Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
44.44Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
44.44Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
44.44Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
44.44Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
44.44Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
44.44Consensusvasop-oxy_onOrthosteric Ligandv2_on
44.44Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
44.00Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
44.00Single4IARErgotamine4IAR-5-HT1B-Ergotamine
44.00Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
44.00Single7F8XNN90567F8X-CCKA-NN9056
44.00Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
44.00Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
44.00Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
44.00Single9HB3Mambaquaretin-19HB3-V2-Mambaquaretin-1
44.00Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
43.75Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
43.48Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
43.48Single4RWADIPP-NH24RWA-δ-DIPP-NH2
43.48Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
43.48Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
43.48Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
43.48Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
43.48Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
43.48Single7YITNalfurafine7YIT-κ-Nalfurafine
43.48Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
43.48Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
43.48Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
43.48Single8JJLOlodaterol8JJL-β2-Olodaterol
43.48Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
43.48Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
43.48Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
43.48Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
43.48Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
43.48Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
43.48Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
43.48Consensusorexin_onOrthosteric Ligandox2_on
43.33Single6IGLIRL16206IGL-ETB-IRL1620
42.86Single3EMLZM-2413853EML-A2A-ZM-241385
42.86Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
42.86Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
42.86Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
42.86Single5UENDU1725UEN-A1-DU172
42.86Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
42.86Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
42.86Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
42.86Single6S0LZM-2413856S0L-A2A-ZM-241385
42.86Single6TOTLemborexant6TOT-OX1-Lemborexant
42.86Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
42.86Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
42.86Single7UL4Alvimopan7UL4-μ-Alvimopan
42.86Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
42.86Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
42.86Single8CU6LJ-45178CU6-A2A-LJ-4517
42.86Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
42.86Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
42.86Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
42.86Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
42.86Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
42.86Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
42.86Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
42.86Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
42.86Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
42.86Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
42.86Single8ZRTET-18ZRT-ETB-ET-1
42.86Single9H37A1IR09H37-A2A-A1IR0-Na
42.86Consensusa3_onOrthosteric Liganda3a_on
42.86Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
42.86Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
42.86Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
42.86Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
42.31Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
42.31Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
42.31Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
42.31Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
42.11Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
42.11Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
41.94Single6IGKEndothelin-36IGK-ETB-Endothelin-3
41.67Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
41.67Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
41.67Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
41.67Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
41.67Single6IBLArformoterol6IBL-β1-Arformoterol
41.67Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
41.67Single7EZCUKA7EZC-A2A-UKA
41.67Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
41.67Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
41.67Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
41.67Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
41.67Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
41.67Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
41.67Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
41.67Single9M54Neuropeptide VF9M54-NPFF2-Neuropeptide VF-Gi1/β1/γ2
41.67Consensuscck_onOrthosteric Ligandccka_on cckb_on
41.67Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
41.67Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
41.67Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
41.67Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
41.67Consensusprostanoid_offOrthosteric Ligandep_off dp_off
41.38Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
41.38Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
41.38Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
41.38Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
41.38Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
41.38Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
40.91Single2YCWS-Carazolol2YCW-β1-S-Carazolol
40.91Single5C1MBU725C1M-μ-BU72
40.91Single5D6LS-Carazolol5D6L-β2-S-Carazolol
40.91Single5IUAQ274563485IUA-A2A-Q27456348-Na
40.91Single5X7DS-Carazolol5X7D-β2-S-Carazolol-Cmpd-15
40.91Single6D26Fevipiprant6D26-DP2-Fevipiprant
40.91Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
40.91Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
40.91Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
40.91Single6S0QZM-2413856S0Q-A2A-ZM-241385
40.91Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
40.91Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
40.91Single7C61Ergotamine7C61-5-HT1B-Ergotamine
40.91Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
40.91Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
40.91Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
40.91Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
40.91Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
40.91Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
40.91Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
40.91Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
40.91Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
40.91Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
40.91Single8GNEKW-63568GNE-A2A-KW-6356-Na
40.91Single8TF5Oleic acid8TF5-GPR6-Oleic acid
40.91Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
40.91Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
40.91Single8XYKVUF106618XYK-CXCR3-VUF10661-Go/β1/γ2
40.91Single9EE8Adenosine9EE8-A2A-Adenosine-Gs/β1/γ2
40.91Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
40.91Consensusa3_on_gpOrthosteric Liganda3a_on_gp
40.91Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
40.91Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
40.91Consensusadenosine_offOrthosteric Liganda1_off a2_off
40.91Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
40.91Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
40.91Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
40.91Consensusdp_offOrthosteric Liganddp2_off
40.91Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
40.74Single5WF5UK-4320975WF5-A2A-UK-432097
40.74Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
40.74Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
40.74Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
40.74Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
40.74Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
40.74Single9U4WGonadoliberin-19U4W-GnRH1-Gonadoliberin-1-chim(NtGi1L-Gs-CtGq)/β1/γ2
40.74Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
40.74Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
40.74Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
40.74Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
40.74Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
40.74Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
40.62Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
40.00Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
40.00Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
40.00Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
40.00Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
40.00Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
40.00Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
40.00Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
40.00Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
40.00Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
40.00Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
40.00Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
40.00Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
40.00Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
40.00Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
40.00Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
40.00Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
40.00Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
40.00Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
40.00Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
40.00Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
40.00Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
40.00Single8Y72Peptide8Y72-μ-Peptide-BMS-986122-Gi1/β1/γ2
40.00Single9KDFRES-701-39KDF-ETB-RES-701-3
40.00Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
40.00Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
40.00Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
40.00Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
40.00Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
39.29Single6JODAngiotensin II6JOD-AT2-Angiotensin II
39.29Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
39.29Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
39.29Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
39.29Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
39.29Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
39.29Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
39.29Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
39.29Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
39.29Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
39.29Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
39.29Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
39.13Single2YDVNECA2YDV-A2A-NECA
39.13Single4UHRCGS216804UHR-A2A-CGS21680
39.13Single5D5AS-Carazolol5D5A-β2-S-Carazolol
39.13Single5D5BS-Carazolol5D5B-β2-S-Carazolol
39.13Single5G53NECA5G53-A2A-NECA-Gs
39.13Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
39.13Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
39.13Single7PX4PSB-21137PX4-A2A-PSB-2113
39.13Single7TUYGSK682753A7TUY-GPR183-GSK682753A
39.13Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
39.13Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
39.13Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
39.13Single8E0GBU728E0G-μ-BU72
39.13Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
39.13Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
39.13Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
39.13Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
39.13Single8Y73Peptide8Y73-μ-Peptide-MPAM-15-Gi1/β1/γ2
39.13Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
39.13Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
39.13Single9BJKNaloxone9BJK-μ-Naloxone-NAM
39.13Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
39.13Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
39.13Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
39.13Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
39.13Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
39.13Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
38.71Single8IY6Endothelin-18IY6-ETB-Endothelin-1
38.71Consensusendothelin_onOrthosteric Ligandetb_on eta_on
38.46Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
38.46Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
38.46Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
38.46Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
38.46Single9M4TSilodosin9M4T-Alpha1A-Silodosin
38.46Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
38.46Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
38.46Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
38.46Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
38.46Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
38.46Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
38.46Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
38.10Single2YDOAdenosine2YDO-A2A-Adenosine
38.10Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
38.10Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
38.10Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
38.10Single4MBSMaraviroc4MBS-CCR5-Maraviroc
38.10Single4ZJCSB-6740424ZJC-OX1-SB-674042
38.10Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
38.10Single5IU7Q274563465IU7-A2A-Q27456346-Na
38.10Single5IUBQ274563445IUB-A2A-Q27456344-Na
38.10Single5JTBZM-2413855JTB-A2A-ZM-241385
38.10Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
38.10Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
38.10Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
38.10Single5UVIZM-2413855UVI-A2A-ZM-241385
38.10Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
38.10Single6PS0S-Carazolol6PS0-β2-S-Carazolol
38.10Single6PS4ICI118-5516PS4-β2-ICI118-551
38.10Single6TPGEMPA6TPG-OX2-EMPA
38.10Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
38.10Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
38.10Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
38.10Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
38.10Single7F61PF-036547467F61-H3-PF-03654746
38.10Single7T94LY21196207T94-M2-Acetylcholine-LY2119620-chim(NtGi1-Go)/β1/γ2
38.10Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
38.10Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
38.10Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
38.10Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
38.10Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
38.10Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
38.10Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
38.10Single8IHKAcifran8IHK-HCA3-Acifran
38.10Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
38.10Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
38.10Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
38.10Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
38.10Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
38.10Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
38.10Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
38.10Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
38.10Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
38.10Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
38.10Single8ZPMAMD0708ZPM-CXCR4-AMD070
38.10Consensusa2_offOrthosteric Liganda2a_off
38.10Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
38.10Consensushca_onOrthosteric Ligandhca2_on
37.93Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
37.93Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
37.93Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
37.93Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
37.93Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
37.93Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
37.93Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
37.93Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
37.93Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
37.93Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
37.93Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
37.93Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
37.93Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
37.93Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
37.93Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
37.50Single3D4STimolol3D4S-β2-Timolol
37.50Single4AMIBucindolol4AMI-β1-Bucindolol
37.50Single5GLHEndothelin-15GLH-ETB-Endothelin-1
37.50Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
37.50Single6MXTSalmeterol6MXT-β2-Salmeterol
37.50Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
37.50Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
37.50Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
37.50Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
37.50Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
37.50Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
37.50Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
37.50Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
37.50Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
37.50Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
37.50Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
37.50Single8JJ8Formoterol8JJ8-β2-Formoterol
37.50Single8XYIVUF106618XYI-CXCR3-VUF10661
37.50Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
37.50Single9EBIPiclidenoson9EBI-A3A-Piclidenoson-chim(NtGi1L-Gs-CtGi1)/β1/γ2
37.50Single9M4QDoxazosin9M4Q-Alpha1A-Doxazosin
37.50Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
37.50Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
37.50Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
37.50Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
37.50Consensusalpha1_offOrthosteric Ligandalpha1a_off
37.50Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
37.50Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
37.50Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
37.50Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
37.50Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
37.50Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
37.50Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
37.50Consensusbombesin_onOrthosteric Ligandbb2_on
37.50Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
37.50Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
37.50Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
37.50Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
37.50Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
37.50Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
37.50Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
37.04Single6HLOAprepitant6HLO-NK1-Aprepitant
37.04Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
37.04Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
37.04Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
37.04Single7XNACYN1548067XNA-SST2-CYN154806
37.04Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
37.04Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
37.04Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
37.04Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
37.04Single9E82SDF-1-beta9E82-ACKR3-SDF-1-β-Arrestin2
37.04Single9IQRMuscarinic toxin 39IQR-α2a-Muscarinic toxin 3
37.04Single9IQSMuscarinic toxin 39IQS-M4-Muscarinic toxin 3
37.04Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
37.04Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
37.04Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
37.04Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
36.67Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
36.36Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
36.36Single3NY8ICI118-5513NY8-β2-ICI118-551
36.36Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
36.36Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
36.36Single4EJ4Naltrindole4EJ4-δ-Naltrindole
36.36Single4GBRS-Carazolol4GBR-β2-S-Carazolol
36.36Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
36.36Single4QKX35V4QKX-β2-35V
36.36Single5IU8Q274563475IU8-A2A-Q27456347-Na
36.36Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
36.36Single6D27CAY104716D27-DP2-CAY10471
36.36Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
36.36Single6PS1Timolol6PS1-β2-Timolol
36.36Single6XBM5LWE6XBM-SMO-5LWE-Gi1/β1/γ2
36.36Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
36.36Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
36.36Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
36.36Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
36.36Single7PYRPSB-21157PYR-A2A-PSB-2115
36.36Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
36.36Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
36.36Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
36.36Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
36.36Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
36.36Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
36.36Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
36.36Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
36.36Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
36.36Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
36.36Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
36.36Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
36.36Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
36.36Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
36.36Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
36.36Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
36.36Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
36.36Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
36.36Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
36.36Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
36.36Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
36.36Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
36.36Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
36.36Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
36.36Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
36.36Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
36.36Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
36.36Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
36.36Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
36.36Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
36.36Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
36.36Single8K5DGSK2560738K5D-HCA2-GSK256073
36.36Single8PJKST1718PJK-5-HT1A-ST171-Gi1/β1/γ1
36.36Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
36.36Single8T1WCVN4248T1W-GPR6-CVN424
36.36Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
36.36Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
36.36Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
36.36Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
36.36Single9CHXS-Carazolol9CHX-β2-S-Carazolol
36.36Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
36.36Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
36.36Single9KFJPubChem 1383196749KFJ-RXFP3-PubChem 138319674-Gi2/β1/γ2
36.36Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
36.36Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
36.36Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
36.36Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
36.36Consensusdopamine_offOrthosteric Ligandd2_off d3_off
36.36Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
36.36Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
36.36Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
36.36Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
36.36Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
36.36Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
36.36Consensushca_on_gpOrthosteric Ligandhca2_on_gp
36.00Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
36.00Single6H7LDobutamine6H7L-β1-Dobutamine
36.00Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
36.00Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
36.00Single7UM4AS26747237UM4-5-HT5A-AS2674723
36.00Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
36.00Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
36.00Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
36.00Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
36.00Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
36.00Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
36.00Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
36.00Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
36.00Single8ZPLHF511168ZPL-CXCR4-HF51116
36.00Single8ZWGJR14a8ZWG-C3aB-JR14a-Gi1/β1/γ2
36.00Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
36.00Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
36.00Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
36.00Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
36.00Consensusendothelin_offOrthosteric Ligandetb_off
36.00Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
36.00Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
36.00Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
36.00Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
36.00Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
35.71Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
35.71Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
35.71Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
35.71Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
35.71Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
35.71Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
35.71Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
35.71Single9M1OMorphine-Modulating Neuropeptide B9M1O-NPFF2-Morphine-Modulating Neuropeptide B-Gi1/β1/γ2
35.71Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
35.71Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
35.71Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
35.71Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
35.71Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
35.48Single8W8WAlpha-MSH8W8W-MC3-α-MSH-Ca-Gs/β1/γ2
35.48Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
35.29Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
35.00Single3OE9IT1t3OE9-CXCR4-IT1t
35.00Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
35.00Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
35.00Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
35.00Single8K5BNiacin8K5B-HCA2-Niacin
35.00Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
35.00Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
34.78Single2RH1S-Carazolol2RH1-β2-S-Carazolol
34.78Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
34.78Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
34.78Single5JQHS-Carazolol5JQH-β2-S-Carazolol
34.78Single5N2RPSB-365N2R-A2A-PSB-36-Na
34.78Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
34.78Single5TVNLSD5TVN-5-HT2B-LSD
34.78Single5WIUNemonapride5WIU-D4-Nemonapride
34.78Single5WIVNemonapride5WIV-D4-Nemonapride-Na
34.78Single5WQCEMPA5WQC-OX2-EMPA
34.78Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
34.78Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
34.78Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
34.78Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
34.78Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
34.78Single6PS6Timolol6PS6-β2-Timolol
34.78Single6TP6Filorexant6TP6-OX1-Filorexant
34.78Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
34.78Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
34.78Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
34.78Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
34.78Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
34.78Single7W41PD1762527W41-BB2-PD176252
34.78Single7WC6LSD7WC6-5-HT2A-LSD
34.78Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
34.78Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
34.78Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
34.78Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
34.78Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
34.78Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
34.78Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
34.78Single8QOTNanobody-E8QOT-μ-Nanobody-E
34.78Single8S4DCMF-0198S4D-Apelin-CMF-019
34.78Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
34.78Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
34.78Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
34.78Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
34.78Single9CIBFCH-22964139CIB-HCA2-FCH-2296413
34.78Single9EHSLUF76029EHS-A3A-LUF7602
34.78Single9F34FOB02-04A9F34-D3-FOB02-04A-Go/β1/γ2
34.78Single9I52A1IZU9I52-D1-A1IZU-Gs/β1/γ2
34.78Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
34.78Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
34.78Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
34.78Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
34.78Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
34.78Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
34.78Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
34.78Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
34.78Consensusamine_offonOrthosteric Ligandamine_off amine_on
34.78Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
34.78Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
34.78Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
34.78Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
34.78Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
34.78Consensusbombesin_offOrthosteric Ligandbb2_off
34.78Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
34.78Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
34.78Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
34.78Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
34.78Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
34.78Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
34.78Consensustrace-amine_onOrthosteric Ligandta1_on
34.62Single5ZTYAM102575ZTY-CB2-AM10257
34.62Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
34.62Single6PT3DPI-2876PT3-δ-DPI-287
34.62Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
34.62Single8X5YAstemizole8X5Y-H1-Astemizole
34.62Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
34.62Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
34.62Single9IPVJR14a9IPV-C3aB-JR14a-Gi1/β1/γ2
34.62Single9IPYJR14a9IPY-C3aB-JR14a
34.62Single9IZASCH9002719IZA-HCA2-SCH900271-Gi1/β1/γ2
34.62Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
34.62Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
34.48Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
34.48Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
34.48Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
34.48Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
34.48Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
34.48Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
34.48Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
34.48Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
34.48Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
34.38Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
34.38Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
34.38Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
33.33Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
33.33Single3P0GBI1671073P0G-β2-BI167107
33.33Single3PWHZM-2413853PWH-A2A-ZM-241385
33.33Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
33.33Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
33.33Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
33.33Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
33.33Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
33.33Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
33.33Single5WS3EMPA5WS3-OX2-EMPA
33.33Single6AKXA4R6AKX-CCR5-A4R
33.33Single6AKYMaraviroc6AKY-CCR5-Maraviroc
33.33Single6H7JIsoprenaline6H7J-β1-Isoprenaline
33.33Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
33.33Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
33.33Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
33.33Single6TODEMPA6TOD-OX1-EMPA-Na
33.33Single6WGTLSD6WGT-5-HT2A-LSD
33.33Single7B6WCyclazosin7B6W-α1b-Cyclazosin
33.33Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
33.33Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
33.33Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
33.33Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
33.33Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
33.33Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
33.33Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
33.33Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
33.33Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
33.33Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
33.33Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
33.33Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
33.33Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
33.33Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
33.33Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
33.33Single7XRRLemborexant7XRR-OX2-Lemborexant
33.33Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
33.33Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
33.33Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
33.33Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
33.33Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
33.33Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
33.33Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
33.33Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
33.33Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
33.33Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
33.33Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
33.33Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
33.33Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
33.33Single8IEBA1LYA8IEB-GPR156-A1LYA
33.33Single8IEIA1LYA8IEI-GPR156-A1LYA
33.33Single8IEPA1LYA8IEP-GPR156-A1LYA
33.33Single8IEPA1LYA8IEP-GPR156-A1LYA
33.33Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
33.33Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
33.33Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
33.33Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
33.33Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
33.33Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
33.33Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
33.33Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
33.33Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
33.33Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
33.33Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
33.33Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
33.33Single8PKMBefiradol8PKM-5-HT1A-Befiradol-Gi1/β1/γ1
33.33Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
33.33Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
33.33Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
33.33Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
33.33Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
33.33Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
33.33Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
33.33Single8YYWAlpha-ketoglutarate8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
33.33Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
33.33Single8ZWFJR14a8ZWF-C3aB-JR14a
33.33Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
33.33Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
33.33Single9EBHAdenosine9EBH-A3A-Adenosine-Gi1/β1/γ2
33.33Single9EEAAdenosine9EEA-A2A-Adenosine-Gs/β1/γ2
33.33Single9H2XA1IR19H2X-A2A-A1IR1-Na
33.33Single9I54A1IZV9I54-D1-A1IZV-Gs/β1/γ2
33.33Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
33.33Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
33.33Single9UY3Anamorelin9UY3-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
33.33Consensusalpha2_offOrthosteric Ligandalpha2c_off
33.33Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
33.33Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
33.33Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
33.33Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
33.33Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
33.33Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
33.33Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
33.33Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
33.33Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
33.33Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
33.33Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
33.33Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
33.33Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
33.33Consensusorexin_offOrthosteric Ligandox2_off ox1_off
33.33Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
33.33Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
33.33Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
33.33Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
33.33Consensussomatostatin_offOrthosteric Ligandsst2_off
33.33Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
33.33Consensustachykinin_offOrthosteric Ligandnk1_off
33.33Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
32.43Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
32.35Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
32.35Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
32.35Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
32.26Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
32.26Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
32.14Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
32.14Single8IEBA1LYA8IEB-GPR156-A1LYA
32.14Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
32.14Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
32.00Single4LDEBI1671074LDE-β2-BI167107
32.00Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
32.00Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
32.00Single6A93Risperidone6A93-5-HT2A-Risperidone
32.00Single6OS2TRV0266OS2-AT1-TRV026
32.00Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
32.00Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
32.00Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
32.00Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
32.00Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
32.00Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
32.00Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
32.00Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
32.00Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
32.00Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
32.00Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
32.00Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
32.00Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
32.00Single8JWY2-1188JWY-A2A-2-118
32.00Single8JWZAB9288JWZ-A2A-AB928-Na
32.00Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
32.00Single8Y6WTUG-13758Y6W-FFA2-TUG-1375-4-CMTB-Gi1/β1/γ2
32.00Single9GL2Befiradol9GL2-5-HT1A-Befiradol-Gs/β1/γ2
32.00Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
32.00Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
32.00Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
32.00Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
32.00Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
32.00Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
32.00Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
32.00Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
32.00Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
32.00Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
32.00Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
32.00Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
32.00Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
32.00Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
32.00Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
32.00Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
31.82Single3REYXAC3REY-A2A-XAC
31.82Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
31.82Single6AQFZM-2413856AQF-A2A-ZM-241385
31.82Single6KUXRS-799486KUX-α2a-RS-79948
31.82Single6PS5S-Propranolol6PS5-β2-S-Propranolol
31.82Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
31.82Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
31.82Single6V9SGTPL114036V9S-OX1-GTPL11403
31.82Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
31.82Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
31.82Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
31.82Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
31.82Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
31.82Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
31.82Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
31.82Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
31.82Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
31.82Single7UL3Famotidine7UL3-H2-Famotidine
31.82Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
31.82Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
31.82Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
31.82Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
31.82Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
31.82Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
31.82Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
31.82Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
31.82Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
31.82Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.82Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.82Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
31.82Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
31.82Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
31.82Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
31.82Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
31.82Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
31.82Single8K5CAcipimox8K5C-HCA2-Acipimox
31.82Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
31.82Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.82Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.82Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
31.82Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
31.82Single8Y6YGLPG09748Y6Y-FFA2-GLPG0974
31.82Single8ZPNAMD31008ZPN-CXCR4-AMD3100
31.82Single9AS5Mescaline9AS5-5-HT2A-Mescaline
31.82Single9AS6Mescaline9AS6-5-HT2A-Mescaline-chim(NtGi1-Gs-CtGq)/β1/γ2
31.82Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
31.82Single9JH3CMF-0199JH3-Apelin-CMF-019-Gi1/β1/γ2
31.82Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
31.82Consensusalpha1_onOrthosteric Ligandalpha1a_on
31.82Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
31.82Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
31.82Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
31.82Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
31.82Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
31.82Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
31.82Consensusgrh_offOrthosteric Ligandgnrh1_off
31.82Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
31.58Single3RFMCaffeine3RFM-A2A-Caffeine
31.58Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
31.58Single8A2OTheophylline8A2O-A2A-Theophylline-Na
31.58Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
31.58Single9EE9Adenosine9EE9-A2A-Adenosine-Gs/β1/γ2
31.25Single8W8XBeta-MSH8W8X-MC3-β-MSH-Ca-Gs/β1/γ2
31.03Single3OE0CVX153OE0-CXCR4-CVX15
31.03Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
31.03Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
31.03Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
31.03Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
30.77Single5X93K-87945X93-ETB-K-8794
30.77Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
30.77Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
30.77Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
30.77Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
30.77Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
30.77Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
30.77Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
30.77Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
30.77Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
30.77Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
30.77Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
30.77Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
30.77Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
30.77Single8S2TIsoprenaline8S2T-β1-Isoprenaline-chim(NtGi1-Gs)/β1/γ2
30.77Single8XVUCXCL28XVU-CXCR2-CXCL2
30.77Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
30.77Single9CGJC6-Quino9CGJ-δ-C6-Quino-Gi1/β1/γ2
30.77Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
30.77Consensuschemerin_onOrthosteric Ligandcml1_on
30.77Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
30.77Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
30.77Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
30.43Single2Y02Carmoterol2Y02-β1-Carmoterol
30.43Single2Y04Salbutamol2Y04-β1-Salbutamol
30.43Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
30.43Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
30.43Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
30.43Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
30.43Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
30.43Single5DHHSB-6121115DHH-NOP-SB-612111
30.43Single5UIGCmpd-15UIG-A2A-Cmpd-1
30.43Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
30.43Single6H7MSalbutamol6H7M-β1-Salbutamol
30.43Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
30.43Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
30.43Single7BU7BI1671077BU7-β1-BI167107
30.43Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
30.43Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
30.43Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
30.43Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
30.43Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
30.43Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
30.43Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
30.43Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
30.43Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
30.43Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
30.43Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
30.43Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
30.43Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
30.43Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
30.43Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
30.43Single8JJOAlprenolol8JJO-β2-Alprenolol
30.43Single8JXRLSD8JXR-D1-LSD
30.43Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
30.43Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
30.43Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
30.43Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
30.43Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
30.43Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
30.43Single9IZCMK19039IZC-HCA2-MK1903-Gi1/β1/γ2
30.43Single9JGKBalovaptan9JGK-5-HT2B-Balovaptan
30.43Single9PLNN-(5-methylnaphthalen-1-yl)pyridin-4-amine9PLN-α2a-N-(5-methylnaphthalen-1-yl)pyridin-4-amine
30.43Single9PLON-(5-methylnaphthalen-1-yl)pyridin-4-amine9PLO-α2a-N-(5-methylnaphthalen-1-yl)pyridin-4-amine-Go/β1/γ2
30.43Single9PQD(6m)-1-methyl-6-(1,2,5,6-tetrahydropyridin-3-yl)-1h-indole9PQD-α2a-(6m)-1-methyl-6-(1,2,5,6-tetrahydropyridin-3-yl)-1h-indole
30.43Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
30.43Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
30.43Consensus5ht5_onOrthosteric Ligand5ht5a_on
30.43Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
30.43Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
30.43Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
30.43Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
30.43Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
30.43Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
30.43Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
30.43Consensuscck_offOrthosteric Ligandccka_off
30.43Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
30.43Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
30.43Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
30.43Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
30.43Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
30.43Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
30.43Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
30.43Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
30.43Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
30.30Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
30.30Consensuspth1_onOrthosteric Ligand6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
30.00Single3OE6IT1t3OE6-CXCR4-IT1t
30.00Single3UZAGTPL92363UZA-A2A-GTPL9236
30.00Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
30.00Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
30.00Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/β1/γ2
30.00Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
30.00Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.00Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
30.00Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
30.00Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
30.00Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
30.00Consensus5ht2_onOrthosteric Ligand5ht2b_on
30.00Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
30.00Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
29.63Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
29.63Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
29.63Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
29.63Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
29.63Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
29.63Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
29.63Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
29.63Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
29.63Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
29.63Single8XQJJN2418XQJ-Apelin-JN241
29.63Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
29.63Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
29.63Single9CGKC5-Quino9CGK-δ-C5-Quino-Gi1/β1/γ2
29.63Single9MD1Buspirone9MD1-5-HT1A-Buspirone-Gz/β1/γ2
29.63Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
29.63Consensuskisspeptin_onOrthosteric Ligandkiss1_on
29.63Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
29.63Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
29.17Single2Y00Dobutamine2Y00-β1-Dobutamine
29.17Single2Y03Isoprenaline2Y03-β1-Isoprenaline
29.17Single4NTJAZD12834NTJ-P2Y12-AZD1283
29.17Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
29.17Single6E67BI1671076E67-β2-BI167107-Gs(CT)
29.17Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
29.17Single6LUQHaloperidol6LUQ-D2-Haloperidol
29.17Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
29.17Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
29.17Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
29.17Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
29.17Single7SINNPS-21437SIN-CaS-NPS-2143
29.17Single7SINNPS-21437SIN-CaS-NPS-2143
29.17Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
29.17Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
29.17Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
29.17Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
29.17Single8JXSPF-61428JXS-D1-PF-6142
29.17Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
29.17Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
29.17Single8WGBVU01550418WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
29.17Single8ZYTNeurotensin peptide 8-138ZYT-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
29.17Single9ARYSerotonin9ARY-5-HT2A-Serotonin-chim(NtGi1-Gs-CtGq)/β1/γ2
29.17Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
29.17Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
29.17Single9HAPTolvaptan9HAP-V2-Tolvaptan
29.17Single9K07DSO-5a9K07-BB3-DSO-5a-chim(NtGi2L-Gs-CtGq)/β1/γ2
29.17Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
29.17Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
29.17Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
29.17Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
29.17Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
29.17Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
29.17Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
29.17Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
29.17Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
29.17Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
29.17Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
29.03Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
29.03Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
29.03Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
29.03Consensuspac_onOrthosteric Ligandpac1_on
28.95Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
28.57Single3PBLEticlopride3PBL-D3-Eticlopride
28.57Single4XT1Fractalkine4XT1-US28-Fractalkine
28.57Single6HLLCP999946HLL-NK1-CP99994
28.57Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
28.57Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
28.57Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
28.57Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
28.57Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
28.57Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
28.57Single7QA8Peptide7QA8-STE2-Peptide
28.57Single7QA8Peptide7QA8-STE2-Peptide
28.57Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
28.57Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
28.57Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
28.57Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
28.57Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
28.57Single8IEIA1LYA8IEI-GPR156-A1LYA
28.57Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
28.57Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
28.57Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
28.57Single8U4OCXCL128U4O-CXCR4-CXCL12-Gi1/β1/γ2
28.57Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
28.57Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
28.57Single8XWNCXCL88XWN-CXCR2-CXCL8
28.57Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
28.57Single9IXJHistamine9IXJ-H2-Histamine-Gs/β1/γ2
28.57Single9J0IUDP-Glucuronic acid9J0I-P2Y14-UDP-Glucuronic acid-Gi1/β1/γ2
28.57Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
28.57Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
28.57Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
28.57Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
28.57Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
28.57Consensuslpl_onOrthosteric Ligands1p_on lpa_on
28.57Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
28.12Single4XT3Fractalkine4XT3-US28-Fractalkine
28.12Single6FJ3PTH6FJ3-PTH1-PTH
28.12Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
28.12Single7SK3CXCL127SK3-ACKR3-CXCL12
28.12Consensuspac_on_gpOrthosteric Ligandpac1_on_gp
28.00Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
28.00Single4DJHJDTic4DJH-κ-JDTic
28.00Single5V54Methiothepin5V54-5-HT1B-Methiothepin
28.00Single5XR8AM8415XR8-CB1-AM841
28.00Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
28.00Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
28.00Single6J20Aprepitant6J20-NK1-Aprepitant
28.00Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
28.00Single6TQ7SB-3348676TQ7-OX1-SB-334867
28.00Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
28.00Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
28.00Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
28.00Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
28.00Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
28.00Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
28.00Single7T9NDPPC7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
28.00Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
28.00Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
28.00Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
28.00Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
28.00Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
28.00Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
28.00Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
28.00Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
28.00Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
28.00Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
28.00Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
28.00Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
28.00Single8XVLZibotentan8XVL-ETA-Zibotentan
28.00Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
28.00Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
28.00Single9JMCDS-3801b9JMC-Motilin-DS-3801b-chim(Gs-CtGq)/β1/γ2
28.00Consensus5ht1_offOrthosteric Ligand5ht1b_off
28.00Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
28.00Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
28.00Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
28.00Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
28.00Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
28.00Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
28.00Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
28.00Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
27.78Consensuspth1_on_gpOrthosteric Ligand6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
27.59Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
27.59Single7SK5CXCL127SK5-ACKR3-CXCL12
27.59Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
27.59Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
27.59Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
27.59Single9J0FNADH9J0F-P2Y14-NADH-Gi1/β1/γ2
27.59Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
27.59Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
27.59Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
27.59Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
27.27Single3ODUIT1t3ODU-CXCR4-IT1t
27.27Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
27.27Single4S0VSuvorexant4S0V-OX2-Suvorexant
27.27Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
27.27Single5ZKQABT-4915ZKQ-PAF-ABT-491
27.27Single6B73MP11046B73-κ-MP1104
27.27Single6DS0Ly2660976DS0-5-HT2B-Ly266097
27.27Single6ME9Ramelteon6ME9-MT2-Ramelteon
27.27Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
27.27Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
27.27Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
27.27Single6TPJSuvorexant6TPJ-OX2-Suvorexant
27.27Single7BR3Elagolix7BR3-GnRH1-Elagolix
27.27Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
27.27Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
27.27Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
27.27Single7F8ULintitript7F8U-CCKA-Lintitript
27.27Single7F8YDevazepide7F8Y-CCKA-Devazepide
27.27Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
27.27Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
27.27Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
27.27Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
27.27Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
27.27Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
27.27Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
27.27Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
27.27Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
27.27Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
27.27Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
27.27Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
27.27Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
27.27Single8IWESpermidine8IWE-TA9-Spermidine
27.27Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
27.27Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
27.27Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
27.27Single8Y0HVUF114188Y0H-CXCR3-VUF11418
27.27Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go/β1/γ2
27.27Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
27.27Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
27.27Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
27.27Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
27.27Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
27.27Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
27.27Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
27.27Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
27.27Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
27.03Consensusclass-a_class-b1_cons_on_gpOrthosteric Ligandclass-a_on_gp class-b1_on_gp
26.92Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
26.92Single4N4WSANT-14N4W-SMO-SANT-1
26.92Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
26.92Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
26.92Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
26.92Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
26.92Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
26.92Single6ZG4HTL00099366ZG4-M1-HTL0009936
26.92Single7DFPSpiperone7DFP-D2-Spiperone
26.92Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
26.92Single7K15MKD0467K15-BLT1-MKD046-Na
26.92Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
26.92Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
26.92Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
26.92Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
26.92Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
26.92Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
26.92Single8XWACXCL18XWA-CXCR2-CXCL1
26.92Single8XWMCXCL68XWM-CXCR2-CXCL6
26.92Single8XWSCXCL58XWS-CXCR2-CXCL5
26.92Single9CM3TUG-13759CM3-FFA2-TUG-1375-Compound 187-chim(NtGi1L-Gs-CtGq)/β1/γ2
26.92Single9DGIZ85267113509DGI-CB1-Z8526711350
26.92Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
26.92Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
26.92Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
26.92Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
26.92Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
26.92Consensuslpa_offOrthosteric Ligandlpa1_off
26.92Consensuslpl_offOrthosteric Ligands1p_off lpa_off
26.92Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
26.92Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
26.67Single8W8YGamma-MSH8W8Y-MC3-γ-MSH-Ca-Gs/β1/γ2
26.32Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
26.32Single7V68LY21196207V68-M4-Iperoxo-LY2119620-Gi1/β1/γ2
26.32Single8PWNTheophylline8PWN-A2A-Theophylline
26.09Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
26.09Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
26.09Single6IQLL7458706IQL-D4-L745870
26.09Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
26.09Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
26.09Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
26.09Single6TP3Nemorexant6TP3-OX1-Nemorexant
26.09Single6VI4JDTic6VI4-κ-JDTic
26.09Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
26.09Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
26.09Single6ZG9GSK10347026ZG9-M1-GSK1034702
26.09Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
26.09Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
26.09Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
26.09Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
26.09Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
26.09Single7T32ZM-2413857T32-A2A-ZM-241385
26.09Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
26.09Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
26.09Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
26.09Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
26.09Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
26.09Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
26.09Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
26.09Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
26.09Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
26.09Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
26.09Single8K9LDamgo8K9L-μ-Damgo-BMS-986122-Gi3/β1/γ1
26.09Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
26.09Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
26.09Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
26.09Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
26.09Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
26.09Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
26.09Single9ARXSerotonin9ARX-5-HT2A-Serotonin
26.09Single9AS3LSD9AS3-5-HT2A-LSD
26.09Single9AS4LSD9AS4-5-HT2A-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
26.09Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
26.09Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
26.09Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
26.09Single9JMDAzithromycin9JMD-Motilin-Azithromycin-chim(Gs-CtGq)/β1/γ2
26.09Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Gi1/β1/γ2
26.09Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
26.09Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
26.09Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
26.09Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
25.93Single4BUONeurotensin4BUO-NTS1-Neurotensin
25.93Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
25.93Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
25.93Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
25.93Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
25.93Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
25.93Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
25.93Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
25.93Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
25.93Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
25.93Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-SBI-553-chim(NtGi1-Go)/β1/γ2
25.93Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
25.93Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
25.93Single8T3OTUG-8918T3O-FFA4-TUG-891-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.93Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
25.93Single8XVJMacitentan8XVJ-ETA-Macitentan
25.93Single8XWFCXCL38XWF-CXCR2-CXCL3
25.93Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
25.93Single9AS02-bromo-LSD9AS0-5-HT2A-2-bromo-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
25.93Single9DYEBuspirone9DYE-5-HT1A-Buspirone-Go/β1/γ2
25.93Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
25.93Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
25.93Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
25.93Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
25.81Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
25.81Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
25.71Consensusclass-a_class-b1_cons_onOrthosteric Ligandclass-a_on class-b1_on
25.00Single2Y01Dobutamine2Y01-β1-Dobutamine
25.00Single5DHGC-355DHG-NOP-C-35
25.00Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
25.00Single6DRXLisuride6DRX-5-HT2B-Lisuride
25.00Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
25.00Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
25.00Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
25.00Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
25.00Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
25.00Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
25.00Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
25.00Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
25.00Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
25.00Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
25.00Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
25.00Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Single7SK9CCX6627SK9-ACKR3-CCX662
25.00Single7V3ZCP559407V3Z-CB1-CP55940
25.00Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
25.00Single7WC7Lisuride7WC7-5-HT2A-Lisuride
25.00Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
25.00Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
25.00Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
25.00Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
25.00Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
25.00Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
25.00Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
25.00Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
25.00Single8IWM2-Phenylethylamine8IWM-TA9-2-Phenylethylamine
25.00Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
25.00Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
25.00Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
25.00Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
25.00Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
25.00Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
25.00Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
25.00Single8WC5Tetramethylammonium Ion8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
25.00Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
25.00Single8X64Desloratadine8X64-H1-Desloratadine
25.00Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
25.00Single9CM7TUG-13759CM7-FFA2-TUG-1375-AZ-1729-Gi1/β1/γ2
25.00Single9JF4PD1683689JF4-BB1-PD168368
25.00Single9NS9TUG-13759NS9-FFA2-TUG-1375-Compound 187-Gi1/β1/γ2
25.00Consensusalpha2_onOrthosteric Ligandalpha2b_on
25.00Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
25.00Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
25.00Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
25.00Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
25.00Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
25.00Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
25.00Consensuspth2_on_gpOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
25.00Consensussensory_onOrthosteric Ligandopsins_on
24.24Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
24.24Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
24.24Consensuspac1_onOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
24.24Consensuspac1_on_gpOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
24.14Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
24.14Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
24.14Single8KIGSHU91198KIG-MC3-SHU9119-Ca
24.14Single8WKYPG-9348WKY-MC4-PG-934
24.14Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
24.00Single5XPRBosentan5XPR-ETB-Bosentan
24.00Single6HLPNetupitant6HLP-NK1-Netupitant
24.00Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
24.00Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
24.00Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
24.00Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
24.00Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
24.00Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
24.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
24.00Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
24.00Single8ZMFA1L108ZMF-5-HT2C-A1L10
24.00Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
24.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
24.00Single9DYDAsenapine9DYD-5-HT1A-Asenapine-Go/β1/γ2
24.00Single9DYFAsenapine9DYF-5-HT1A-Asenapine-Gi1/β1/γ2
24.00Single9F33FOB02-04A9F33-D3-FOB02-04A-Go/β1/γ2
24.00Single9GE2ML1849GE2-GPR55-ML184-chim(NtGi1-G13)/β1/γ2
24.00Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
24.00Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
23.81Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
23.81Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
23.81Single6ME5Agomelatine6ME5-MT1-Agomelatine
23.81Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
23.81Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
23.81Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
23.81Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
23.81Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.81Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
23.81Single8IW72-Phenylethylamine8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
23.81Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
23.81Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
23.81Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
23.81Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
23.81Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
23.81Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
23.81Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
23.81Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
23.81Single9LRCHistamine9LRC-H4-Histamine
23.81Single9LREHistamine9LRE-H4-Histamine-Gi1/β1/γ2
23.81Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
23.81Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
23.81Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
23.81Consensusgi_sensoryOrthosteric Ligandgi_opsins
23.81Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
23.81Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
23.81Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
23.81Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
23.81Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
23.81Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
23.81Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
23.68Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
23.53Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
23.53Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
23.53Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
23.33Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
23.33Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
23.33Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
23.08Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
23.08Single4U15Tiotropium4U15-M3-Tiotropium
23.08Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
23.08Single5V56TC1145V56-SMO-TC114
23.08Single5XRAAM115425XRA-CB1-AM11542
23.08Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
23.08Single6E59L-7607356E59-NK1-L-760735
23.08Single6OL9Tiotropium6OL9-M5-Tiotropium
23.08Single6OS1TRV0266OS1-AT1-TRV026
23.08Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
23.08Single7FEECP559407FEE-CB1-CP55940-ZCZ011
23.08Single7R0CAVP7R0C-V2-AVP-Arrestin2
23.08Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
23.08Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
23.08Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
23.08Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
23.08Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
23.08Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
23.08Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
23.08Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
23.08Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
23.08Single9CLWTUG-13759CLW-FFA2-TUG-1375-4-CMTB-chim(NtGi1L-Gs-CtGq)/β1/γ2
23.08Single9EGOYVF9EGO-CB1-YVF-Gi1/β1/γ2
23.08Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
23.08Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
23.08Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
23.08Consensuslpa_onOrthosteric Ligandlpa1_on
23.08Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
23.08Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
23.08Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
23.08Consensuspth_onOrthosteric Ligandpth1_on pth2_on
22.86Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
22.86Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
22.86Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
22.86Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
22.86Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
22.86Single9BYOExendin-39BYO-GLP-1-Exendin-3-Gs/β1/γ2
22.86Consensusvip-pacap_onOrthosteric Ligandvpac_on pac_on
22.86Consensusvip-pacap_on_gpOrthosteric Ligandvpac_on_gp pac_on_gp
22.73Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
22.73Single7SRQLSD7SRQ-5-HT2B-LSD
22.73Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
22.73Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
22.73Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
22.73Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
22.73Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
22.73Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
22.73Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
22.73Single8YN7Immethridine8YN7-H3-Immethridine-Go/β1/γ2
22.73Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
22.73Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
22.73Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
22.73Single9IZDCHBA9IZD-HCA1-CHBA-Gi1/β1/γ2
22.73Single9LMPNE52-QQ579LMP-GPR4-NE52-QQ57
22.73Consensusgq_nucleotideOrthosteric Ligandgq_p2y
22.73Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
22.58Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
22.58Single6W25SHU91196W25-MC4-SHU9119-Ca
22.58Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
22.22Single4PY02MeSATP4PY0-P2Y12-2MeSATP
22.22Single4XEENeurotensin4XEE-NTS1-Neurotensin
22.22Single4XESNeurotensin4XES-NTS1-Neurotensin
22.22Single5CXVTiotropium5CXV-M1-Tiotropium
22.22Single5TZYMK8666; AP85TZY-FFA1-MK8666; AP8
22.22Single6CM4Risperidone6CM4-D2-Risperidone
22.22Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
22.22Single6KQICP559406KQI-CB1-CP55940-Org27569
22.22Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
22.22Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
22.22Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
22.22Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
22.22Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
22.22Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
22.22Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
22.22Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.22Single8JD3JNJ-404118138JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
22.22Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
22.22Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
22.22Single8XQJJN2418XQJ-Apelin-JN241
22.22Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
22.22Single9GGGI-BOP9GGG-TXA2-I-BOP-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.22Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
22.22Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
22.22Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
22.22Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
22.22Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
21.88Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
21.88Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
21.88Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
21.88Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
21.88Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
21.74Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
21.74Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
21.74Single6ME2Ramelteon6ME2-MT1-Ramelteon
21.74Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
21.74Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
21.74Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
21.74Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
21.74Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
21.74Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
21.74Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
21.74Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
21.74Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
21.74Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
21.74Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
21.74Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
21.74Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.74Single8U4PAMD31008U4P-CXCR4-AMD3100-Gi1/β1/γ2
21.74Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
21.74Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
21.74Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
21.74Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
21.74Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ2
21.74Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
21.74Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
21.74Single8YYWAlpha-ketoglutarate8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
21.74Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
21.74Single9K6LSA09K6L-TAS2R16-SA0-Gi2/β1/γ2
21.74Single9KPESA09KPE-TAS2R16-SA0-Gi1/β1/γ2
21.74Consensusangiotensin_offOrthosteric Ligandat1_off
21.74Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
21.74Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
21.74Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
21.74Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
21.74Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
21.74Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
21.74Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
21.74Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
21.74Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
21.74Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
21.74Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
21.74Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
21.62Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
21.62Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
21.62Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
21.62Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
21.43Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
21.43Single6K1QIRL25006K1Q-ETB-IRL2500
21.43Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
21.43Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
21.43Single8JPFNeurotensin8JPF-NTS1-Neurotensin-SBI-553
21.43Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Consensusfp-alpha_onOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
21.21Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
21.21Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
21.21Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
21.05Single5MZPCaffeine5MZP-A2A-Caffeine-Na
21.05Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
21.05Single8GEJConstrained Epinephrine8GEJ-β2-Constrained Epinephrine-Gs/β1/γ2
21.05Consensuscrf1_on_gpOrthosteric Ligand6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF1-Corticoliberin-Gs/β1/γ2
21.05Consensusglp1_on_gpOrthosteric Ligand7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
20.93Consensuspth_on_gpOrthosteric Ligandpth1_on_gp pth2_on_gp
20.83Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
20.83Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
20.83Single6A94Zotepine6A94-5-HT2A-Zotepine
20.83Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
20.83Single6TPKRetosiban6TPK-OT-Retosiban
20.83Single6TPNHTL66416TPN-OX2-HTL6641
20.83Single7T94Acetylcholine7T94-M2-Acetylcholine-LY2119620-chim(NtGi1-Go)/β1/γ2
20.83Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
20.83Single7UTZDPPC7UTZ-TSH-TR1402-DPPC-Gs/β1/γ2
20.83Single7VV6C48/807VV6-MRGPRX2-C48/80
20.83Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
20.83Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
20.83Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
20.83Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
20.83Single8RLNLUF58348RLN-A2A-LUF5834
20.83Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
20.83Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
20.83Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
20.83Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Single9IXXLTD49IXX-CysLT2-LTD4-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Single9JFUNE52-QQ579JFU-GPR4-NE52-QQ57
20.83Single9K0XATP9K0X-P2Y2-ATP-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Single9K20ATP9K20-P2Y2-ATP-chim(NtGi1-Go)/β1/γ2
20.83Single9KPDSA09KPD-TAS2R16-SA0-chim(Gs-CtGt3)/β1/γ2
20.83Single9LRDHistamine9LRD-H1-Histamine-Gi1/β1/γ2
20.83Single9M2FNeuropeptide FF9M2F-NPFF1-Neuropeptide FF-Gi1/β1/γ2
20.83Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
20.83Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
20.83Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
20.83Consensusvasop-oxy_offOrthosteric Ligandot_off
20.69Single6KNMJN241-96KNM-Apelin-JN241-9
20.69Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
20.69Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
20.69Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
20.69Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
20.69Single9JH6C20:0 Ceramide9JH6-CysLT2-C20:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
20.59Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
20.59Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
20.59Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
20.59Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
20.59Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
20.59Consensuscrf2_on_gpOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
20.59Consensussecretin_onOrthosteric Ligand7D3S-Secretin-Secretin-Gs/β1/γ2
20.59Consensusvpac1_on_gpOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
20.51Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
20.51Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
20.00Single3PXOAll-trans-Retinal3PXO-Rhodopsin-All-trans-Retinal
20.00Single4QIMANTA XV4QIM-SMO-ANTA XV
20.00Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
20.00Single4YAYZD-71554YAY-AT1-ZD-7155
20.00Single5DYSAll-trans-Retinal5DYS-Rhodopsin-All-trans-Retinal
20.00Single5TGZAM65385TGZ-CB1-AM6538
20.00Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
20.00Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
20.00Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
20.00Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
20.00Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
20.00Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
20.00Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
20.00Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
20.00Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
20.00Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
20.00Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
20.00Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
20.00Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
20.00Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
20.00Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
20.00Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
20.00Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
20.00Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
20.00Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
20.00Single8TH3AT118-H Nanobody8TH3-AT1-AT118-H Nanobody
20.00Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
20.00Single8X63Mepyramine8X63-H1-Mepyramine
20.00Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
20.00Single8YN8Proxyfan8YN8-H3-Proxyfan-Go/β1/γ2
20.00Single9AS1DMT9AS1-5-HT2A-DMT
20.00Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
20.00Single9BUCCagrilintide9BUC-CT-Cagrilintide-Gs/β1/γ2
20.00Single9JEAAtropine9JEA-M1-Atropine
20.00Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
20.00Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
20.00Consensusblt_onOrthosteric Ligandblt1_on
20.00Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
20.00Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
20.00Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
20.00Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
20.00Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
20.00Consensusglp_onOrthosteric Ligandglp1_on glp2_on
20.00Consensusglp_on_gpOrthosteric Ligandglp1_on_gp glp2_on_gp
20.00Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
20.00Consensushistamine_offOrthosteric Ligandh1_off
20.00Consensusleukotriene_onOrthosteric Ligandblt_on
20.00Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
20.00Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
20.00Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
20.00Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
20.00Consensussecretin_on_gpOrthosteric Ligand7D3S-Secretin-Secretin-Gs/β1/γ2
19.44Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
19.44Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
19.44Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
19.44Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
19.44Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
19.44Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
19.35Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
19.23Single4JKVTaladegib4JKV-SMO-Taladegib
19.23Single5CGCHTL142425CGC-mGlu5-HTL14242
19.23Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
19.23Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
19.23Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
19.23Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
19.23Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
19.23Single6Z4SSR486926Z4S-NTS1-SR48692
19.23Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
19.23Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
19.23Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
19.23Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
19.23Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
19.23Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
19.23Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
19.23Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
19.23Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
19.23Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
19.23Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
19.23Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
19.23Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
19.23Single9ARZ2-bromo-LSD9ARZ-5-HT2A-2-bromo-LSD
19.23Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
19.23Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
19.23Single9KPFSA09KPF-TAS2R16-SA0-Gi1/β1/γ2
19.23Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
19.23Consensusblt_offOrthosteric Ligandblt1_off
19.23Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
19.23Consensusep_offOrthosteric Ligandep4_off
19.23Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
19.23Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
19.23Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
19.23Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
19.23Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
19.23Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
19.23Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
19.23Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
19.23Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
19.05Single3OE8IT1t3OE8-CXCR4-IT1t
19.05Single6OY9All-trans-Retinal6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
19.05Single6TQ9SB-4081246TQ9-OX1-SB-408124
19.05Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
19.05Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
19.05Single9CHUNoradrenaline9CHU-β2-Noradrenaline
19.05Consensusclass-b1_onOrthosteric Ligandglucagon_on vip-pacap_on pth_on crf_on calcitonin_on
19.05Consensusgs_histamineOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
19.05Consensush2_onOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
18.92Consensuscrf1_onOrthosteric Ligand6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF1-Corticoliberin-Gs/β1/γ2
18.75Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
18.75Single9B5YLong-Acting PTH9B5Y-PTH1-Long-Acting PTH-chim(NtGi1-Gq)/β1/γ2
18.75Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
18.75Consensusclass-b1_class-b2_cons_onOrthosteric Ligandclass-b1_on class-b2_on
18.75Consensusclass-b1_class-b2_cons_on_gpOrthosteric Ligandclass-b1_on_gp class-b2_on_gp
18.60Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
18.52Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
18.52Single4BV0Neurotensin4BV0-NTS1-Neurotensin
18.52Single5TZRMK86665TZR-FFA1-MK8666
18.52Single5V57TC1145V57-SMO-TC114
18.52Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
18.52Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
18.52Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
18.52Single7F1TMIP-1a7F1T-CCR5-MIP-1a
18.52Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
18.52Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
18.52Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
18.52Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
18.52Single8EA0Iperoxo8EA0-M3-Iperoxo
18.52Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
18.52Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
18.52Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
18.52Single8YNTSNAP-948478YNT-MCH1-SNAP-94847
18.52Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
18.52Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
18.52Consensusneurotensin_onOrthosteric Ligandnts1_on
18.52Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
18.52Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
18.42Consensusglp1_onOrthosteric Ligand7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
18.18Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
18.18Single3PQRAll-trans-Retinal3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
18.18Single4XNWMRS25004XNW-P2Y1-MRS2500
18.18Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
18.18Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
18.18Single7WC5Psilocin7WC5-5-HT2A-Psilocin
18.18Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
18.18Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
18.18Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
18.18Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
18.18Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
18.18Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
18.18Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
18.18Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
18.18Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
18.18Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ2
18.18Single9BLCCagrilintide backbone (non-acylated)9BLC-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
18.18Single9EBOGLP-1 (ACPC18)9EBO-GLP-1-GLP-1 (ACPC18)-Gs/β1/γ2
18.18Single9JHJC18:0 Ceramide9JHJ-FPR2-ALX-C18:0 Ceramide-Gi1/β1/γ2
18.18Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
18.18Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
18.18Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
17.95Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
17.95Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
17.95Consensuscrf_on_gpOrthosteric Ligandcrf2_on_gp crf1_on_gp
17.86Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
17.86Single6YVRNTS8-136YVR-NTS1-NTS8-13
17.86Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
17.86Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
17.86Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
17.86Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
17.86Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
17.86Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
17.86Single8XJNCloprosetnol8XJN-TXA2-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
17.86Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
17.86Single9BJKNAM9BJK-μ-Naloxone-NAM
17.86Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
17.86Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
17.86Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
17.65Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
17.65Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
17.65Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
17.65Consensuscalcitonin_onOrthosteric Ligandctlike_on
17.65Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
17.65Consensusvpac1_onOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
17.65Consensusvpac_onOrthosteric Ligandvpac1_on vpac2_on
17.50Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
17.50Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
17.50Consensusglucagon_onOrthosteric Ligandglp_on gluc_on secretin_on gip_on
17.39Single5L7IVismodegib5L7I-SMO-Vismodegib
17.39Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
17.39Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
17.39Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
17.39Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
17.39Single6TP4ACT-4622066TP4-OX1-ACT-462206
17.39Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
17.39Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
17.39Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.39Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
17.39Single7UL2SR486927UL2-NTS1-SR48692-Na
17.39Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
17.39Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
17.39Single7XP6Strychnine7XP6-TAS2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
17.39Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.39Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
17.39Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
17.39Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab
17.39Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
17.39Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
17.39Single9AS2DMT9AS2-5-HT2A-DMT-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Single9AS7Psilocin9AS7-5-HT2A-Psilocin
17.39Single9B9Y7DY9B9Y-CB1-7DY
17.39Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
17.39Single9E7RGB889E7R-PAR2-GB88-chim(NtGi1L-Gs-CtGq)/β1/γ2
17.39Single9EPRRetinal9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
17.39Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg4_on
17.39Consensusadgrg_on_gpOrthosteric Ligandadgrg2_on_gp adgrg4_on_gp
17.39Consensusclass-b1_on_gpOrthosteric Ligandglucagon_on_gp vip-pacap_on_gp pth_on_gp crf_on_gp calcitonin_on_gp
17.39Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
17.39Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
17.39Consensusneurotensin_offOrthosteric Ligandnts1_off
17.39Consensusnts1_offOrthosteric Ligand7UL2-NTS1-SR48692-Na
17.24Single5CGDHTL142425CGD-mGlu5-HTL14242
17.24Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
17.24Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
17.24Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
17.24Single8XJOU466198XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
17.24Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
17.24Single9GG5U466199GG5-TXA2-U46619-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.24Single9JH5C16:0 Ceramide9JH5-CysLT2-C16:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
17.24Single9M1HProstaglandin E29M1H-EP1-Prostaglandin E2-chim(NtGi1-Gs-CtGq)/β1/γ2
17.24Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
17.24Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
17.24Consensustp_onOrthosteric Ligand8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
17.24Consensustp_on_gpOrthosteric Ligand8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
17.14Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
17.14Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
17.14Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
17.14Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
17.14Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
17.14Single9BLWCagrilintide backbone (non-acylated)9BLW-CT (AMY1)-Cagrilintide backbone (non-acylated)-Gs/β1/γ2; RAMP1
17.14Single9BP3Cagrilintide9BP3-CT (AMY1)-Cagrilintide-Gs/β1/γ2; RAMP1
17.14Consensuscalcitonin_on_gpOrthosteric Ligandctlike_on_gp
17.14Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
17.14Consensusvpac_on_gpOrthosteric Ligandvpac1_on_gp vpac2_on_gp
17.07Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
17.07Consensusglucagon_on_gpOrthosteric Ligandglp_on_gp gluc_on_gp secretin_on_gp gip_on_gp
16.67Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
16.67Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
16.67Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
16.67Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
16.67Single4BWBNeurotensin4BWB-NTS1-Neurotensin
16.67Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
16.67Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
16.67Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
16.67Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
16.67Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
16.67Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
16.67Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
16.67Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
16.67Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
16.67Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
16.67Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
16.67Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
16.67Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
16.67Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
16.67Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
16.67Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
16.67Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single9LRBHistamine9LRB-H1-Histamine-Gs/β1/γ2
16.67Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
16.67Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
16.67Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
16.67Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
16.22Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
16.22Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
16.22Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
16.22Consensusctlike_on_gpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
16.22Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
16.22Consensusvpac2_on_gpOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
16.13Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.13Single8YWFRetatrutide8YWF-GLP-1-Retatrutide-chim(NtGi1-Gs)/β1/γ2
16.00Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
16.00Single3RZECidoxepin3RZE-H1-Cidoxepin
16.00Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
16.00Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
16.00Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
16.00Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
16.00Single6ZINSR486926ZIN-NTS1-SR48692
16.00Single7VODCariprazine7VOD-5-HT2A-Cariprazine
16.00Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
16.00Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
16.00Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
16.00Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
16.00Single8K2WAMG4878K2W-CXCR3-AMG487
16.00Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
16.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.00Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
16.00Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
16.00Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
16.00Single9BA0A1AKN9BA0-CB1-A1AKN
16.00Single9K0KUTP9K0K-P2Y4-UTP-chim(NtGi1-Gs-CtGq)/β1/γ2
16.00Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
16.00Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
16.00Consensusopsins_offOrthosteric Ligandrhodopsin_off
16.00Consensussensory_offOrthosteric Ligandopsins_off
15.79Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
15.79Single7RBTTirzepatide7RBT-GIP-Tirzepatide-LSN3556672-chim(NtGi1-Gs)/β1/γ2
15.79Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
15.79Consensusgip_onOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
15.79Consensusgip_on_gpOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
15.62Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
15.62Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
15.38Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
15.38Single4DAJTiotropium4DAJ-M3-Tiotropium
15.38Single4MQSIperoxo4MQS-M2-Iperoxo
15.38Single4U14Tiotropium4U14-M3-Tiotropium
15.38Single5DSGTiotropium5DSG-M4-Tiotropium
15.38Single6GPSMK08126GPS-CCR2-MK0812
15.38Single6IIVDaltroban6IIV-TXA2-Daltroban
15.38Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
15.38Single7F83PF-051904577F83-Ghrelin-PF-05190457
15.38Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
15.38Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
15.38Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
15.38Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
15.38Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
15.38Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
15.38Single7YXAONO-54306087YXA-S1P5-ONO-5430608
15.38Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.38Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
15.38Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
15.38Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
15.38Single8ZYYNeurotensin peptide 8-138ZYY-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
15.38Single9AUCCalcitonin gene-related peptide-19AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
15.38Single9IYAONO-97105319IYA-GPR55-ONO-9710531
15.38Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
15.38Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
15.38Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
15.38Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
15.00Single4A4MAll-trans-Retinal4A4M-Rhodopsin-All-trans-Retinal-Gt(CT)
15.00Single5EN0All-trans-Retinal5EN0-Rhodopsin-All-trans-Retinal-Gt(CT)
15.00Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
15.00Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
15.00Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
15.00Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
14.81Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
14.81Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
14.81Single5T1ABMS-6815T1A-CCR2-BMS-681-PubChem 12093170
14.81Single6GPXMK08126GPX-CCR2-MK0812
14.81Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
14.81Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
14.81Single7C4SS1P7C4S-S1P3-S1P
14.81Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
14.81Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
14.81Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
14.81Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
14.81Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
14.81Single8ZVZBW245C8ZVZ-DP1-BW245C-Gs/β1/γ2
14.81Single9B9ZA1AKO9B9Z-CB1-A1AKO
14.81Single9HC04YI9HC0-mGlu5-4YI
14.81Consensusadgrg2_onOrthosteric Ligand7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
14.81Consensusadgrg2_on_gpOrthosteric Ligand7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
14.71Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
14.71Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
14.71Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
14.71Single9BUDCagrilintide9BUD-CT-Cagrilintide-Gs/β1/γ2
14.63Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
14.29Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
14.29Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
14.29Single7P2L4YI7P2L-mGlu5-4YI
14.29Single7WC4Serotonin7WC4-5-HT2A-Serotonin
14.29Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
14.29Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
14.29Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
14.29Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single8JD5JNJ-40411813; ADX881788JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
14.29Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
14.29Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
14.29Single8ZW0PGD28ZW0-DP1-PGD2-Gs/β1/γ2
14.29Single9AS9RS130-1809AS9-5-HT2A-RS130-180
14.29Single9ASARS130-1809ASA-5-HT2A-RS130-180-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
14.29Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
14.29Consensusgluc_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
13.95Consensusgluc_on_gpOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
13.89Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
13.89Single9BLBCagrilintide backbone (non-acylated)9BLB-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
13.79Single5X33BIIL2605X33-BLT1-BIIL260
13.79Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
13.79Single6IIURamatroban6IIU-TXA2-Ramatroban
13.79Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.79Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
13.79Single9AU0BW245C9AU0-DP1-BW245C-Gs/β1/γ2
13.64Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
13.64Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
13.64Single8Y02Retinal8Y02-OPN1SW-Retinal-Gi1/β1/γ2
13.64Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
13.64Consensusp2y_offOrthosteric Ligandp2y1_off
13.51Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
13.51Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
13.51Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
13.51Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
13.51Consensusglp2_on_gpOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
13.33Single9C0KExendin-49C0K-GLP-1-Exendin-4-Gs/β1/γ2
13.16Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
13.16Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
13.16Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
13.16Single9BQ3Cagrilintide9BQ3-CT (AMY2)-Cagrilintide-Gs/β1/γ2; RAMP2
13.04Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
13.04Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
13.04Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
13.04Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
13.04Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.04Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
12.90Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
12.90Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
12.50Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
12.50Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
12.50Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
12.50Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
12.50Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
12.50Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
12.50Single7V68Iperoxo7V68-M4-Iperoxo-LY2119620-Gi1/β1/γ2
12.50Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
12.50Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
12.50Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Single8YN2Histamine8YN2-H1-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
12.50Single8ZYUNeurotensin peptide 8-138ZYU-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
12.20Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
12.12Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
12.12Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
12.12Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
12.00Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
12.00Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
12.00Single5U09Taranabant5U09-CB1-Taranabant
12.00Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
12.00Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
12.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
12.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
12.00Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.00Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
12.00Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
12.00Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
12.00Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
12.00Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
12.00Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
12.00Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
12.00Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
12.00Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
11.90Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
11.90Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
11.76Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
11.76Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
11.54Single6FFIMMPEP6FFI-mGlu5-MMPEP
11.54Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
11.54Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
11.54Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ2
11.54Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
11.54Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
11.54Single8YRGFospropofol8YRG-MRGPRX4-Fospropofol-chim(NtGi1-Gs-CtGq)/β1/γ2
11.43Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
11.11Single6FFHFenobam6FFH-mGlu5-Fenobam
11.11Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/β1/γ2
11.11Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
11.11Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
11.11Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
11.11Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
11.11Single9IMATalquetamab9IMA-GPRC5D-Talquetamab
10.81Single9BUBCagrilintide9BUB-CT-Cagrilintide-Gs/β1/γ2
10.71Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
10.71Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
10.53Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
10.53Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
10.53Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
10.34Single8GDBPGE28GDB-EP4-PGE2-Gs/β1/γ2
10.34Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
10.26Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
10.26Single9BTWCagrilintide9BTW-CT (AMY3)-Cagrilintide-Gs/β1/γ2; RAMP3
10.00Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
10.00Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
9.68Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
9.68Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
9.38Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
9.09Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
9.09Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
9.09Single7XKDBeta-Hydroxyandrosterone7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
9.09Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
9.09Single9BUECagrilintide9BUE-CT-Cagrilintide-Gs/β1/γ2
8.70Single2HPYAll-trans-Retinal2HPY-Rhodopsin-All-trans-Retinal
8.70Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Gi1/β1/γ2
8.33Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
8.33Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
8.33Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
8.00Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
8.00Single4O9RCyclopamine4O9R-SMO-Cyclopamine
8.00Single6LI0C176LI0-GPR52-C17
8.00Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
8.00Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
7.69Single4QINSAG1.54QIN-SMO-SAG1.5
7.69Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
7.69Single8T3VDocosa-4,7,10,13,16,19-Hexaenoic acid8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.41Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
7.41Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
7.41Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14Single5T04Neurotensin5T04-NTS1-Neurotensin
6.90Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
6.90Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
6.90Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
6.90Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Gi1/β1/γ1
5.00Consensusclass-b2_onOrthosteric Ligandadgrg_on adgrf_on adgrl_on adgre_on adgrd_on
5.00Consensusclass-b2_on_gpOrthosteric Ligandadgrg_on_gp adgrf_on_gp adgrl_on_gp adgre_on_gp adgrd_on_gp
4.76Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
4.76Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
4.55Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/β1/γ2
4.35Single8X9S5alpha-DHT8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
4.17Single6XBM5LWE6XBM-SMO-5LWE-Gi1/β1/γ2
4.17Single7Y14Beta-Alanine7Y14-MRGPRD-β-Alanine
4.00Single7Y12Beta-Alanine7Y12-MRGPRD-β-Alanine-Gi1/β1/γ2
4.00Single8J6QCompound 9n8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
4.00Single8JPSCCL78JPS-ACKR1-CCL7
4.00Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
3.85Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
3.85Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/β1/γ2
3.85Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
3.85Single8YKDDehydroepiandrosterone8YKD-ADGRG2-Dehydroepiandrosterone-chim(NtGi1-Gs)/β1/γ2
3.70Single7VVOPTH7VVO-PTH1-PTH-Gs/β1/γ2
3.57Single8JD6VU03647708JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
3.45Single9IVGGLP-1 (Truncated)9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2

Consensus Members
Id Members
7WIC 7WIC-SST2-Somatostatin-14-Gi1/β1/γ2
7XMS 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2
8X8L 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
7XMT 7XMT-SST4-J-2156-Gi1/β1/γ2
7WIG 7WIG-SST2-L-054,264-Gi1/β1/γ2
8X8N 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
7YAE 7YAE-SST2-Octreotide-Gi1/β1/γ2
7YAC 7YAC-SST2-Paltusotine-Gi1/β1/γ2
Net Summary
Imin 2.405
Number of Linked Nodes 912
Number of Links 1114
Number of Hubs 176
Number of Links mediated by Hubs 695
Number of Communities 17
Number of Nodes involved in Communities 237
Number of Links involved in Communities 356
Path Summary
Number Of Nodes in MetaPath 86
Number Of Links MetaPath 85
Number of Shortest Paths 9890289
Length Of Smallest Path 3
Average Path Length 44.8871
Length of Longest Path 70
Minimum Path Strength 0.4125
Average Path Strength 4.54316
Maximum Path Strength 21.5606
Minimum Path Correlation 0.7
Average Path Correlation 0.985315
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.53846
Average % Of Corr. Nodes 20.8708
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 50.231
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following consensuses:
IdComponents
gi_peptidegi_cck
gi_apelin
gi_compl-pept
gi_endothelin
gi_formylpeptide
gi_galanin
gi_ghrelin
gi_npy
gi_neurotensin
gi_opioid
gi_orexin
gi_relaxin
gi_somatostatin



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