psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	E3.P293	NT.F40	15.89	No	No	0	1	5
2	E3.Q291	NT.C42	6.1	No	No	0	2	8
3	7x24	NT.C42	7.28	No	No	0	4	8
4	7x31	NT.L44	18.76	Yes	No	1	4	2
5	Lig	NT.L44	19.89	Yes	No	1	0	2
6	7x28	NT.T45	8.67	No	No	0	2	3
7	1x32	NT.K46	7.44	No	No	1	3	4
8	E1.T115	NT.K46	9.01	Yes	No	1	4	4
9	Lig	NT.K46	5.29	Yes	No	1	0	4
10	1x30	1x35	9.74	No	No	0	4	6
11	1x30	7x36	9.18	No	No	0	4	5
12	1x31	7x31	10.15	No	Yes	1	4	4
13	1x31	7x35	17.92	No	No	1	4	5
14	1x32	E1.K114	12.41	No	No	0	3	3
15	1x32	E1.T115	5.19	No	Yes	1	3	4
16	1x33	1x34	5.96	No	No	5	3	5
17	1x33	E1.K114	5.97	No	No	0	3	3
18	1x35	1x39	14.07	No	Yes	0	6	7
19	1x35	2x64	8.21	No	No	0	6	5
20	1x36	2x64	5.56	No	No	0	6	5
21	1x36	2x65	15.89	No	No	0	6	4
22	1x39	2x57	4.69	Yes	Yes	0	7	7
23	1x39	2x60	9.38	Yes	No	0	7	7
24	1x39	7x39	4.35	Yes	No	0	7	4
25	1x39	7x42	7.63	Yes	No	0	7	7
26	1x40	2x61	7.36	No	No	0	5	7
27	1x42	7x47	5.12	No	No	0	6	7
28	1x43	2x57	4.87	No	Yes	0	6	7
29	1x43	2x58	7.22	No	No	0	6	9
30	1x47	1x51	7.93	No	No	6	5	3
31	1x47	2x51	7.5	No	Yes	6	5	7
32	1x50	2x50	5.39	No	Yes	0	9	9
33	1x50	7x50	9.77	No	No	0	9	9
34	1x51	2x51	5.28	No	Yes	6	3	7
35	1x57	2x40	5.28	Yes	No	0	6	7
36	1x57	2x44	6.43	Yes	Yes	0	6	5
37	1x57	7x53	5.16	Yes	Yes	0	6	9
38	1x58	1x59	11.8	No	No	0	3	5
39	1x59	1x60	4.53	No	No	0	5	5
40	I1.K81	I1.W83	12.76	No	Yes	0	6	6
41	2x40	I1.W83	4.94	No	Yes	0	7	6
42	2x44	I1.W83	12.03	Yes	Yes	0	5	6
43	4x39	I1.W83	6.96	No	Yes	0	3	6
44	2x37	8x48	8.83	No	No	0	7	5
45	2x38	3x49	4.77	No	No	0	6	8
46	2x39	2x43	4.37	Yes	Yes	0	7	8
47	2x39	3x49	9.28	Yes	No	0	7	8
48	2x39	3x50	11.27	Yes	Yes	0	7	9
49	2x39	8x48	5.6	Yes	No	0	7	5
50	2x40	8x48	5.89	No	No	0	7	5
51	2x41	4x42	5.09	No	No	0	6	8
52	2x42	3x45	10.75	Yes	No	0	7	6
53	2x42	3x46	4.84	Yes	No	0	7	8
54	2x42	4x42	5.34	Yes	No	0	7	8
55	2x42	4x45	9.67	Yes	No	0	7	5
56	2x43	3x46	4.37	Yes	No	0	8	8
57	2x43	7x53	5.99	Yes	Yes	0	8	9
58	2x44	2x48	6.09	Yes	No	0	5	5
59	2x45	3x42	14.5	No	Yes	4	9	7
60	2x45	4x46	5.96	No	No	4	9	7
61	2x45	4x50	10.17	No	No	4	9	9
62	2x46	7x53	5.86	No	Yes	0	9	9
63	2x47	7x53	5.34	No	Yes	0	9	9
64	2x50	3x35	6.73	Yes	No	0	9	8
65	2x50	7x46	10.31	Yes	No	0	9	9
66	2x50	7x49	6.73	Yes	No	0	9	9
67	2x51	2x55	6.09	Yes	No	0	7	5
68	2x53	3x32	7.22	Yes	Yes	0	7	7
69	2x53	3x35	13.96	Yes	No	0	7	8
70	2x53	7x42	6.36	Yes	No	0	7	7
71	2x53	7x46	5.09	Yes	No	0	7	9
72	2x54	2x57	4.47	No	Yes	0	5	7
73	2x56	3x28	8.5	No	No	0	6	4
74	2x56	3x31	4.56	No	No	0	6	4
75	2x60	3x28	5.32	No	No	0	7	4
76	2x62	2x66	8.46	No	No	0	3	4
77	2x62	E1x51	5.02	No	No	2	3	3
78	2x62	E1x52	5.36	No	Yes	2	3	7
79	2x63	2x64	9.93	No	No	0	5	5
80	2x63	E1.T115	8.74	No	Yes	0	5	4
81	2x63	E1x50	10.61	No	Yes	0	5	8
82	2x66	E1x49	5.39	No	No	0	4	5
83	E1.T115	E2.R195	5.17	Yes	Yes	1	4	1
84	E1x49	E2.T199	10.12	No	No	0	5	4
85	E1x50	E1x52	14.03	Yes	Yes	2	8	7
86	3x25	E1x50	5.22	No	Yes	2	9	8
87	3x28	E1x50	5.48	No	Yes	0	4	8
88	E1x50	E2x50	14.37	Yes	No	2	8	9
89	E1x51	E1x52	8.79	No	Yes	2	3	7
90	3x22	3x26	12.44	No	No	0	3	7
91	3x22	E2.T192	4.34	No	No	0	3	5
92	3x25	E2x50	7.28	No	No	2	9	9
93	3x26	E2.G191	5.23	No	No	0	7	4
94	3x29	4x64	5.27	No	No	0	5	5
95	3x29	E2x50	11.14	No	No	0	5	9
96	3x29	E2x52	17.87	No	No	0	5	6
97	3x30	3x34	7.87	Yes	No	0	6	5
98	3x30	4x61	8.53	Yes	No	0	6	5
99	3x32	3x33	9.05	Yes	No	0	7	5
100	3x33	4x60	7.95	No	No	0	5	4
101	3x33	E2x52	6.3	No	No	0	5	6
102	3x34	4x53	4.81	No	No	0	5	7
103	3x35	3x39	4.47	No	No	0	8	9
104	3x36	3x37	14.07	No	Yes	0	7	7
105	3x37	4x57	4.84	Yes	No	0	7	7
106	3x37	5x43	4.99	Yes	No	0	7	5
107	3x37	5x461	10.78	Yes	No	0	7	5
108	3x37	6x52	7.62	Yes	No	0	7	8
109	3x40	6x48	10.88	No	Yes	0	7	8
110	3x42	4x46	5.28	Yes	No	4	7	7
111	3x42	4x49	13.11	Yes	No	0	7	7
112	3x42	4x50	12.03	Yes	No	4	7	9
113	3x44	5x54	6.08	No	No	0	8	8
114	3x47	5x54	6.19	No	No	8	9	8
115	3x47	5x58	10.17	No	Yes	8	9	9
116	3x49	I2x57	18	No	No	0	8	8
117	3x50	6x30	4.86	Yes	No	0	9	4
118	3x50	6x33	6.19	Yes	No	0	9	8
119	3x51	3x55	7.57	Yes	No	3	7	7
120	3x51	3x56	5.96	Yes	No	3	7	6
121	3x51	5x57	5.38	Yes	No	0	7	6
122	3x51	5x60	8.21	Yes	No	0	7	4
123	3x52	I2x56	6.59	Yes	No	0	5	4
124	3x52	I2x57	6.01	Yes	No	0	5	8
125	3x55	3x56	10.09	No	No	3	7	6
126	3x56	I2x52	5.97	No	No	0	6	5
127	I2x51	I2x52	5.64	No	No	0	5	5
128	4x38	4x41	8.39	No	No	0	6	4
129	4x39	4x43	4.36	No	No	0	3	4
130	4x47	4x51	4.47	No	No	0	4	4
131	4x58	4x59	5.34	No	No	0	4	8
132	4x59	5x39	15.3	No	Yes	0	8	5
133	4x60	4x64	4.64	No	No	0	4	5
134	4x60	5x39	4.84	No	Yes	0	4	5
135	4x62	4x63	7.22	No	Yes	0	4	4
136	4x63	E2.T206	8.74	Yes	No	1	4	5
137	4x63	5x35	6.36	Yes	No	0	4	1
138	4x63	5x36	16.88	Yes	Yes	1	4	4
139	4x63	5x39	4.96	Yes	Yes	0	4	5
140	E2.I200	E2.T192	4.56	No	No	0	4	5
141	E2.G193	E2x51	4.35	No	No	0	2	4
142	E2.N197	E2.R195	4.82	No	Yes	1	4	1
143	E2.R195	E2.T199	9.06	Yes	No	1	1	4
144	E2.R195	E2.T201	10.35	Yes	No	0	1	3
145	E2.R195	Lig	8.35	Yes	Yes	1	1	0
146	E2.N197	E2.T199	13.16	No	No	1	4	4
147	E2.T201	E2x51	4.99	No	No	0	3	4
148	E2.S207	E2x51	6.36	No	No	0	5	4
149	7x38	E2x52	9.53	No	No	0	5	6
150	5x36	E2.T205	9.99	Yes	No	1	4	5
151	6x62	E2.T205	6.47	No	No	1	5	5
152	E2.T205	Lig	6.45	No	Yes	1	5	0
153	E2.T206	E2.Y210	4.99	No	No	0	5	4
154	5x36	E2.T206	6.24	Yes	No	1	4	5
155	5x33	6x62	14.58	No	No	0	4	5
156	5x34	6x63	8.5	No	No	0	1	3
157	5x36	6x55	4.78	Yes	No	0	4	6
158	5x36	6x59	4.69	Yes	No	0	4	4
159	5x37	5x41	7.46	No	No	0	4	4
160	5x39	5x43	4.99	Yes	No	0	5	5
161	5x40	6x55	9.18	No	No	0	5	6
162	5x44	6x52	9.58	No	No	0	5	8
163	5x47	6x52	26.02	No	No	0	8	8
164	5x51	5x55	5.54	No	No	0	6	4
165	5x51	6x45	8.53	No	No	0	6	9
166	5x54	5x58	8.46	No	Yes	8	8	9
167	5x58	6x37	8.21	Yes	No	0	9	7
168	5x58	6x38	11.36	Yes	No	0	9	7
169	5x58	6x41	8.83	Yes	No	0	9	7
170	5x58	6x42	4.69	Yes	No	0	9	7
171	5x60	5x63	4.86	No	No	0	4	5
172	5x65	6x31	10.93	No	No	0	8	6
173	6x29	8x52	7.21	No	No	0	4	5
174	6x33	8x49	9.01	No	No	0	8	6
175	6x36	7x55	9.38	No	No	0	6	6
176	6x40	7x52	5.71	No	No	0	4	7
177	6x44	6x48	5.05	No	Yes	0	6	8
178	6x45	6x48	11.35	No	Yes	0	9	8
179	6x48	7x45	11.63	Yes	No	0	8	9
180	6x54	7x33	6.02	No	No	0	5	4
181	6x54	7x37	9.03	No	No	0	5	7
182	6x58	7x30	4.43	No	No	0	4	4
183	6x58	7x34	17.44	No	No	1	4	4
184	6x58	Lig	13.73	No	Yes	1	4	0
185	6x60	6x64	10.72	No	No	0	4	1
186	6x60	E3.F290	5.34	No	No	0	4	3
187	6x61	7x27	4.69	No	No	0	1	2
188	6x62	Lig	24.29	No	Yes	1	5	0
189	7x23	E3.F290	8.71	No	No	0	4	3
190	E3.P293	E3.T292	5.25	No	No	0	1	2
191	7x23	7x27	5.61	No	No	0	4	2
192	7x26	7x27	4.83	No	No	0	1	2
193	7x26	7x30	5.24	No	No	0	1	4
194	7x31	7x35	11.27	Yes	No	1	4	5
195	7x31	Lig	11.72	Yes	Yes	1	4	0
196	7x34	7x38	12.35	No	No	0	4	5
197	7x34	Lig	4.4	No	Yes	1	4	0
198	7x35	7x38	9.35	No	No	0	5	5
199	7x45	7x49	6.81	No	No	0	9	9
200	7x49	7x53	4.65	No	Yes	0	9	9
201	8x49	8x52	11.64	No	No	0	6	5
202	8x51	8x53	50.11	No	No	0	8	5
203	3x32	6x51	4.29	Yes	No	7	7	7
204	3x27	3x31	4.28	No	No	0	4	4
205	5x37	6x60	4.28	No	No	0	4	4
206	8x50	8x51	4.28	No	No	0	8	8
207	2x59	E1x52	4.16	No	Yes	0	6	7
208	5x33	6x63	4.15	No	No	0	4	3
209	6x32	6x36	4.12	No	No	0	5	6
210	1x49	7x50	4.06	No	No	0	6	9
211	1x55	1x59	4.01	No	No	0	3	5
212	3x50	6x34	3.95	Yes	No	0	9	7
213	1x56	1x60	3.94	No	No	0	7	5
214	1x58	2x44	3.93	No	Yes	0	3	5
215	3x25	E2.G191	3.92	No	No	0	9	4
216	2x49	4x50	3.89	No	No	0	8	9
217	3x51	3x52	3.82	Yes	Yes	3	7	5
218	1x54	2x51	3.77	No	Yes	0	7	7
219	3x30	4x57	3.77	Yes	No	0	6	7
220	5x47	6x49	3.77	No	No	0	8	5
221	1x57	I1.M80	3.73	Yes	No	0	6	5
222	NT.G48	NT.T47	3.64	No	No	0	4	2
223	1x39	2x61	3.63	Yes	No	0	7	7
224	3x51	5x61	3.63	Yes	No	0	7	7
225	5x49	5x50	3.53	No	No	0	6	9
226	3x44	5x50	3.5	No	No	0	8	9
227	6x50	7x37	3.5	No	No	0	9	7
228	2x43	8x47	3.49	Yes	No	0	8	8
229	3x40	5x50	3.39	No	No	0	7	9
230	6x49	6x50	3.39	No	No	0	5	9
231	I2x50	I2x52	3.35	No	No	0	8	5
232	E3.Q291	Lig	3.33	No	Yes	0	2	0
233	1x45	7x47	3.27	No	No	0	5	7
234	3x52	I2x53	3.26	Yes	No	3	5	5
235	2x41	4x46	3.23	No	No	0	6	7
236	6x461	6x47	3.23	No	No	0	6	8
237	4x56	5x461	3.22	No	No	0	4	5
238	7x52	7x56	3.15	No	No	0	7	6
239	5x62	5x66	3.07	No	No	0	5	3
240	6x53	6x54	3.04	No	No	0	6	5
241	6x57	7x30	3.04	No	No	0	5	4
242	7x23	E3.T292	3.01	No	No	0	4	2
243	6x47	7x43	3	No	No	0	8	5
244	1x42	2x57	2.98	No	Yes	0	6	7
245	3x41	4x49	2.98	No	No	0	5	7
246	3x54	5x65	2.98	No	No	0	8	8
247	3x54	6x30	2.98	No	No	0	8	4
248	5x49	5x53	2.98	No	No	0	6	6
249	6x461	7x40	2.98	No	No	0	6	7
250	6x35	6x39	2.94	No	No	0	6	4
251	1x33	NT.G48	2.9	No	No	5	3	4
252	1x34	NT.G48	2.9	No	No	5	5	4
253	5x65	6x35	2.85	No	No	0	8	6
254	7x51	7x55	2.85	No	No	0	6	6
255	3x21	E1x50	2.81	No	Yes	0	6	8
256	5x47	5x48	2.79	No	No	0	8	4
257	2x46	3x43	2.77	No	No	0	9	8
258	3x32	7x41	2.77	Yes	No	7	7	7
259	6x51	7x41	2.77	No	No	7	7	7
260	1x53	7x53	2.67	No	Yes	0	8	9
261	5x37	6x56	2.59	No	No	0	4	5
262	1x54	2x44	2.51	No	Yes	0	7	5
263	3x24	E1x52	2.49	No	Yes	0	5	7
264	5x68	6x31	2.48	No	No	0	4	6
265	E2.E209	E2.Y210	2.24	No	No	0	3	4
266	5x63	5x67	2.06	No	No	0	5	5
267	1x46	7x47	1.96	No	No	0	8	7
268	3x52	3x53	1.86	Yes	No	3	5	7
269	3x53	I2x53	1.86	No	No	3	7	5
270	3x38	4x53	1.84	No	No	0	6	7
271	4x38	I2x55	1.74	No	No	0	6	4
272	1x48	1x49	1.71	No	No	0	4	6
273	I2x54	I2x55	1.71	No	No	0	5	4
274	3x54	5x64	1.7	No	No	0	8	5
275	3x55	5x64	1.7	No	No	0	7	5
276	5x38	5x42	1.64	No	No	0	3	3
277	2x43	7x56	1.61	Yes	No	0	8	6
278	3x23	3x24	1.61	No	No	0	1	5
279	5x46	5x461	1.61	No	No	0	4	5
280	1x38	1x42	1.6	No	No	0	4	6
281	6x44	7x48	1.6	No	No	0	6	5
282	6x43	6x461	1.59	No	No	0	4	6
283	NT.K41	NT.S39	1.53	No	No	0	1	7
284	1x52	1x56	1.52	No	No	0	5	7
285	5x41	5x45	1.52	No	No	0	4	5
286	6x39	6x43	1.52	No	No	0	4	4
287	1x40	1x44	1.47	No	No	0	5	5
288	1x41	1x45	1.43	No	No	0	5	5
289	4x48	4x52	1.43	No	No	0	3	5
290	6x40	7x55	1.43	No	No	0	4	6
291	7x28	NT.L44	1.36	No	No	0	2	2
292	3x30	4x54	1.31	Yes	No	0	6	4
293	2x51	2x52	1.22	Yes	No	0	7	7
294	1x60	8x50	1.13	No	No	0	5	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg. Int. Strength	Num. Of Links	Community	ConSurf
1	1x39	7.29167	6	0	7
2	1x57	5.15	4	0	6
3	I1.W83	9.1725	4	0	6
4	2x39	7.63	4	0	7
5	2x42	7.65	4	0	7
6	2x43	3.966	5	0	8
7	2x44	6.198	5	0	5
8	2x50	7.29	4	0	9
9	2x51	4.772	5	6	7
10	2x53	8.1575	4	0	7
11	2x57	4.2525	4	0	7
12	E1.T115	7.0275	4	1	4
13	E1x50	8.75333	6	2	8
14	E1x52	6.966	5	2	7
15	3x30	5.37	4	0	6
16	3x32	5.8325	4	7	7
17	3x37	8.46	5	0	7
18	3x42	11.23	4	4	7
19	3x50	6.5675	4	0	9
20	3x51	5.76167	6	3	7
21	3x52	4.308	5	3	5
22	4x63	8.832	5	1	4
23	E2.R195	7.55	5	1	1
24	5x36	8.516	5	1	4
25	5x39	7.5225	4	0	5
26	5x58	8.62	6	8	9
27	6x48	9.7275	4	0	8
28	7x31	12.975	4	1	4
29	7x53	4.945	6	0	9
30	Lig	10.8278	9	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	7x23	7x27	12.1728	5.61	No	No	0	4	2
2	7x26	7x27	14.3195	4.83	No	No	0	1	2
3	7x26	7x30	15.3852	5.24	No	No	0	1	4
4	6x58	7x30	17.5011	4.43	No	No	0	4	4
5	E1.T115	E2.R195	10.2448	5.17	Yes	Yes	1	4	1
6	E2.R195	Lig	11.2178	8.35	Yes	Yes	1	1	0
7	1x35	2x64	17.6272	8.21	No	No	0	6	5
8	2x63	2x64	16.6928	9.93	No	No	0	5	5
9	2x63	E1.T115	19.9928	8.74	No	Yes	0	5	4
10	7x34	7x38	26.8784	12.35	No	No	0	4	5
11	6x58	7x34	11.9437	17.44	No	No	1	4	4
12	1x35	1x39	19.0404	14.07	No	Yes	0	6	7
13	1x39	2x57	10.963	4.69	Yes	Yes	0	7	7
14	2x60	3x28	14.4766	5.32	No	No	0	7	4
15	3x28	E1x50	13.1638	5.48	No	Yes	0	4	8
16	2x53	7x42	41.548	6.36	Yes	No	0	7	7
17	2x53	3x32	66.0068	7.22	Yes	Yes	0	7	7
18	3x32	3x33	64.7018	9.05	Yes	No	0	7	5
19	3x33	E2x52	37.0537	6.3	No	No	0	5	6
20	7x38	E2x52	31.7923	9.53	No	No	0	5	6
21	1x57	2x44	23.6995	6.43	Yes	Yes	0	6	5
22	1x57	7x53	30.459	5.16	Yes	Yes	0	6	9
23	7x49	7x53	88.4064	4.65	No	Yes	0	9	9
24	2x50	7x49	100	6.73	Yes	No	0	9	9
25	2x50	3x35	51.4582	6.73	Yes	No	0	9	8
26	2x53	3x35	51.6332	13.96	Yes	No	0	7	8
27	2x50	7x46	51.1365	10.31	Yes	No	0	9	9
28	2x53	7x46	51.224	5.09	Yes	No	0	7	9
29	1x58	2x44	11.6399	3.93	No	Yes	0	3	5
30	1x58	1x59	10.3426	11.8	No	No	0	3	5
31	2x39	2x43	41.2855	4.37	Yes	Yes	0	7	8
32	2x43	7x53	61.8471	5.99	Yes	Yes	0	8	9
33	2x39	3x49	20.487	9.28	Yes	No	0	7	8
34	2x39	3x50	22.5257	11.27	Yes	Yes	0	7	9
35	2x41	4x42	11.2976	5.09	No	No	0	6	8
36	2x42	4x42	12.3993	5.34	Yes	No	0	7	8
37	2x42	3x46	15.6684	4.84	Yes	No	0	7	8
38	2x43	3x46	16.6517	4.37	Yes	No	0	8	8
39	2x41	4x46	10.1907	3.23	No	No	0	6	7
40	3x37	5x43	21.2335	4.99	Yes	No	0	7	5
41	5x39	5x43	22.1396	4.99	Yes	No	0	5	5
42	4x63	5x39	12.3375	4.96	Yes	Yes	0	4	5
43	3x33	4x60	28.2092	7.95	No	No	0	5	4
44	3x40	6x48	13.3208	10.88	No	Yes	0	7	8
45	6x48	7x45	19.7457	11.63	Yes	No	0	8	9
46	7x45	7x49	20.7985	6.81	No	No	0	9	9
47	3x40	5x50	12.232	3.39	No	No	0	7	9
48	3x49	I2x57	18.3351	18	No	No	0	8	8
49	3x50	6x30	16.2063	4.86	Yes	No	0	9	4
50	3x51	3x52	12.86	3.82	Yes	Yes	3	7	5
51	3x52	I2x57	17.2257	6.01	Yes	No	0	5	8
52	3x54	6x30	15.169	2.98	No	No	0	8	4
53	3x54	5x65	11.9926	2.98	No	No	0	8	8
54	1x39	7x42	40.8994	7.63	Yes	No	0	7	7
55	7x34	Lig	14.456	4.4	No	Yes	1	4	0
56	4x60	5x39	29.1359	4.84	No	Yes	0	4	5
57	1x39	2x60	14.8833	9.38	Yes	No	0	7	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
E3.Q291	NT.C42	6.1	0	No	No	2	8	1	2
7x31	NT.L44	18.76	1	Yes	No	4	2	1	1
Lig	NT.L44	19.89	1	Yes	No	0	2	0	1
1x32	NT.K46	7.44	1	No	No	3	4	2	1
E1.T115	NT.K46	9.01	1	Yes	No	4	4	2	1
Lig	NT.K46	5.29	1	Yes	No	0	4	0	1
1x31	7x31	10.15	1	No	Yes	4	4	2	1
1x31	7x35	17.92	1	No	No	4	5	2	2
1x32	E1.T115	5.19	1	No	Yes	3	4	2	2
E1.T115	E2.R195	5.17	1	Yes	Yes	4	1	2	1
E2.N197	E2.R195	4.82	1	No	Yes	4	1	2	1
E2.R195	E2.T199	9.06	1	Yes	No	1	4	1	2
E2.R195	E2.T201	10.35	1	Yes	No	1	3	1	2
E2.R195	Lig	8.35	1	Yes	Yes	1	0	1	0
E2.N197	E2.T199	13.16	1	No	No	4	4	2	2
5x36	E2.T205	9.99	1	Yes	No	4	5	2	1
6x62	E2.T205	6.47	1	No	No	5	5	1	1
E2.T205	Lig	6.45	1	No	Yes	5	0	1	0
5x33	6x62	14.58	0	No	No	4	5	2	1
6x58	7x30	4.43	1	No	No	4	4	1	2
6x58	7x34	17.44	1	No	No	4	4	1	1
6x58	Lig	13.73	1	No	Yes	4	0	1	0
6x62	Lig	24.29	1	No	Yes	5	0	1	0
7x31	7x35	11.27	1	Yes	No	4	5	1	2
7x31	Lig	11.72	1	Yes	Yes	4	0	1	0
7x34	7x38	12.35	1	No	No	4	5	1	2
7x34	Lig	4.4	1	No	Yes	4	0	1	0
7x35	7x38	9.35	1	No	No	5	5	2	2
E3.Q291	Lig	3.33	0	No	Yes	2	0	1	0
7x28	NT.L44	1.36	0	No	No	2	2	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
100.00	Single	4XNW	MRS2500	4XNW-P2Y₁-MRS2500
60.00	Consensus	p2y_off	Orthosteric Ligand	p2y1_off p2y12_off
54.55	Consensus	cxcr_on	Orthosteric Ligand	cxcr1_on cxcr2_on
53.85	Single	7SK7	CXCL12	7SK7-ACKR3-CXCL12-CCX662
50.00	Single	4O9R	Cyclopamine	4O9R-SMO-Cyclopamine
50.00	Single	6U1N	LY2119620	6U1N-M₂-LY2119620-Arrestin2
50.00	Single	7SK8	CXCL12	7SK8-ACKR3-CXCL12-CCX662
50.00	Consensus	go_chemokine	Orthosteric Ligand	6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
50.00	Consensus	go_protein	Orthosteric Ligand	go_chemokine
46.15	Single	6LFM	Interleukin-8	6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
46.15	Single	8JPC	Neurotensin 8-13	8JPC-NTS₁-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
45.45	Single	4BWB	Neurotensin	4BWB-NTS₁-Neurotensin
45.45	Single	4QIN	SAG1.5	4QIN-SMO-SAG1.5
45.45	Single	6LFO	Interleukin-8	6LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
45.45	Single	6O3C	SAG21k	6O3C-SMO-SAG21k-Cholesterol
45.45	Single	6WWZ	CCL20	6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
45.45	Consensus	ccr6_on	Orthosteric Ligand	6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
45.45	Consensus	class-f_off	Orthosteric Ligand	smo_off
45.45	Consensus	cxcr1_on	Orthosteric Ligand	8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
42.86	Single	3ZEV	Neurotensin	3ZEV-NTS₁-Neurotensin
42.86	Single	7L0P	Neurotensin	7L0P-NTS₁-Neurotensin-Gi1/&β;1/&γ;1
42.86	Single	7L0Q	Neurotensin	7L0Q-NTS₁-Neurotensin-Gi1/&β;1/&γ;1
42.86	Single	8FMZ	Neurotensin/neuromedin N	8FMZ-NTS₁-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
41.67	Single	7ZI0	SAG	7ZI0-SMO-SAG-Cholesterol
41.67	Consensus	cxcr2_on	Orthosteric Ligand	6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
40.00	Single	4GRV	Neurotensin 8-13	4GRV-NTS₁-Neurotensin 8-13
40.00	Single	4XEE	Neurotensin	4XEE-NTS₁-Neurotensin
40.00	Single	4XES	Neurotensin	4XES-NTS₁-Neurotensin
40.00	Single	6OSA	JMV449	6OSA-NTS₁-JMV449-Gi1/&β;1/&γ;2
40.00	Single	6YVR	NTS8-13	6YVR-NTS₁-NTS8-13
40.00	Single	7L0S	Neurotensin	7L0S-NTS₁-Neurotensin-Gi1/&β;1/γ1
40.00	Single	7V6A	PubChem 9864275	7V6A-M₄-PubChem 9864275-Gi1/&β;1/&γ;2
40.00	Consensus	smo_off_allo	Orthosteric Ligand	6D32-SMO-Cyclopamine-Cyclopamine
38.46	Single	6Z4V	NTS8-13	6Z4V-NTS₁-NTS8-13
38.46	Single	7WQ3	Galanin	7WQ3-GAL₁-Galanin-Gi1/&β;1/&γ;2
38.46	Single	8IC0	Interleukin-8	8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
38.46	Consensus	gal1_on	Orthosteric Ligand	7WQ3-GAL₁-Galanin-Gi1/&β;1/&γ;2
38.46	Consensus	gi_galanin	Orthosteric Ligand	7WQ3-GAL₁-Galanin-Gi1/&β;1/&γ;2
38.46	Consensus	nucleotide_off	Orthosteric Ligand	adenosine_off p2y_off
37.50	Single	4BUO	Neurotensin	4BUO-NTS₁-Neurotensin
37.50	Single	6OS9	JMV449	6OS9-NTS₁-JMV449-Gi1/&β;1/&γ;2
37.50	Single	8JPF	Neurotensin	8JPF-NTS₁-Neurotensin-PubChem 118610427
37.50	Consensus	gi_neurotensin	Orthosteric Ligand	7L0P-NTS₁-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS₁-JMV449-Gi1/&β;1/&γ;2
36.36	Single	4MQT	LY2119620	4MQT-M₂-Iperoxo-LY2119620
36.36	Single	5L7I	Vismodegib	5L7I-SMO-Vismodegib
36.36	Single	7TRP	LY2033298	7TRP-M₄-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
35.71	Single	6Z8N	SRI-9829	6Z8N-NTS₁-SRI-9829
35.71	Single	8FN1	Neurotensin/neuromedin N	8FN1-NTS₁-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
35.29	Single	6KNM	JN241-9	6KNM-Apelin-JN241-9
35.29	Single	7W2Z	Ghrelin	7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
35.29	Consensus	chemokine_on	Orthosteric Ligand	cxcr_on cx3cr_on
35.29	Consensus	go_ghrelin	Orthosteric Ligand	7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
35.29	Consensus	motilin_on	Orthosteric Ligand	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
35.29	Consensus	protein_on	Orthosteric Ligand	ccr_on chemokine_on gphr_on chemerin_on
33.33	Single	4BV0	Neurotensin	4BV0-NTS₁-Neurotensin
33.33	Single	5OLO	Tozadenant	5OLO-A_2A-Tozadenant-Na
33.33	Single	6OS1	TRV026	6OS1-AT₁-TRV026
33.33	Single	6PWC	Neurotensin	6PWC-NTS₁-Neurotensin-Arrestin2
33.33	Single	6UP7	Neurotensin	6UP7-NTS₁-Neurotensin-Arrestin2
33.33	Single	7L0R	Neurotensin	7L0R-NTS₁-Neurotensin-Gi1/&β;1/&γ;1
33.33	Single	7T94	PubChem 57664406	7T94-M₂-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
33.33	Single	7V68	PubChem 57664406	7V68-M₄-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
33.33	Single	7XBD	Galanin	7XBD-GAL₂-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33	Single	8FN0	Neurotensin/neuromedin N	8FN0-NTS₁-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
33.33	Single	8U4P	AMD3100	8U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
33.33	Consensus	go_class-a	Orthosteric Ligand	go_amine go_peptide go_protein
33.33	Consensus	m2_on_allo	Other Ligand	7T94-M₂-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M₂-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
31.58	Single	7C6A	(Sar1,Ile8)-Angiotensin II	7C6A-AT₂-(Sar1,Ile8)-Angiotensin II
31.58	Single	8IBV	Motilin	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.25	Single	6OS0	Angiotensinogen	6OS0-AT₁-Angiotensinogen
31.25	Single	6OS2	TRV026	6OS2-AT₁-TRV026
31.25	Single	7L1U	Orexin	7L1U-OX₂-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.25	Single	7XJK	Galanin	7XJK-GAL₂-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
31.25	Single	8IBU	Erythromycin A	8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.25	Single	8J6D	EP141	8J6D-C3a_B-EP141-Go/&β;1/&γ;2
31.25	Single	8JPB	Neurotensin 8-13	8JPB-NTS₁-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
31.25	Single	8U26	Protachykinin-1	8U26-NK₁-Protachykinin-1-Gs/&β;1/&γ;2
31.25	Consensus	chemokine_off	Orthosteric Ligand	cxcr_off
31.25	Consensus	cxcr4_off	Orthosteric Ligand	4RWS-CXCR4-vMIP-II
31.25	Consensus	cxcr_off	Orthosteric Ligand	cxcr4_off
31.25	Consensus	galanin_on	Orthosteric Ligand	gal2_on gal1_on
31.25	Consensus	nts1_on	Orthosteric Ligand	6OS9-NTS₁-JMV449-Gi1/&β;1/&γ;2
31.25	Consensus	nts_on	Orthosteric Ligand	nts1_on
30.77	Single	5K2B	ZM241385	5K2B-A_2A-ZM241385-Na
30.77	Single	5NLX	ZM241385	5NLX-A_2A-ZM241385-Na
30.77	Single	5UVI	ZM241385	5UVI-A_2A-ZM241385
30.77	Single	6XBL	SAG	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
30.77	Single	7UTZ	PubChem 644078	7UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
30.77	Single	7XJJ	Galanin	7XJJ-GAL₁-Galanin-Go/&β;1/&γ;2
30.77	Single	7XXH	2MeSADP	7XXH-P2Y₁-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
30.77	Consensus	gi_class-f	Orthosteric Ligand	gi_frizzled
30.77	Consensus	gi_frizzled	Orthosteric Ligand	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
30.77	Consensus	gnrh_off	Orthosteric Ligand	gnrh1_off
30.77	Consensus	go_galanin	Orthosteric Ligand	7XJJ-GAL₁-Galanin-Go/&β;1/&γ;2
30.77	Consensus	lh_on_allo	Other Ligand	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
30.00	Single	3OE0	CVX15	3OE0-CXCR4-CVX15
30.00	Consensus	go_peptide	Orthosteric Ligand	go_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
30.00	Consensus	gs_motilin	Orthosteric Ligand	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.41	Single	4RWS	vMIP-II	4RWS-CXCR4-vMIP-II
29.17	Single	8IY5	Endothelin-1	8IY5-ET_B-Endothelin-1-Gi1/&β;1/&γ;2
29.17	Single	8IY6	Endothelin-1	8IY6-ET_B-Endothelin-1
29.17	Consensus	gi_chemokine	Orthosteric Ligand	7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
28.57	Single	3EML	ZM241385	3EML-A_2A-ZM241385
28.57	Single	4QIM	PubChem 24905375	4QIM-SMO-PubChem 24905375
28.57	Single	5K2A	ZM241385	5K2A-A_2A-ZM241385-Na
28.57	Single	5T04	Neurotensin	5T04-NTS₁-Neurotensin
28.57	Single	5VRA	ZM241385	5VRA-A_2A-ZM241385-Na
28.57	Single	6LPJ	ZM241385	6LPJ-A_2A-ZM241385-Na
28.57	Single	6LPK	ZM241385	6LPK-A_2A-ZM241385-Na
28.57	Single	6S0L	ZM241385	6S0L-A_2A-ZM241385
28.57	Single	7FIH	Org43553	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
28.57	Single	7YON	Peptide YY(3-36)	7YON-Y₂-Peptide YY(3-36)-Gi1/&β;1/&γ;2
28.57	Consensus	bk2_on	Orthosteric Ligand	7F2O-BK₂-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK₂-Kallidin-Gq/&β;1/&γ;2
28.57	Consensus	ghrelin_on	Orthosteric Ligand	7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
28.57	Consensus	smo_off	Orthosteric Ligand	5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
28.00	Single	5GLH	Endothelin-1	5GLH-ET_B-Endothelin-1
27.78	Single	7F2O	Bradykinin	7F2O-BK₂-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.78	Single	7NA7	Ghrelin-27	7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
27.78	Single	7YAE	Octreotide	7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
27.78	Consensus	nk1_on	Orthosteric Ligand	8U26-NK₁-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK₁-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.27	Single	6D32	Cyclopamine	6D32-SMO-Cyclopamine-Cyclopamine
27.27	Single	6OIK	LY2119620	6OIK-M₂-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
27.27	Single	7F6H	Bradykinin	7F6H-BK₂-Bradykinin-Gq/&β;1/&γ;2
27.27	Single	7F6I	Kallidin	7F6I-BK₂-Kallidin-Gq/&β;1/&γ;2
27.27	Single	7F9Y	Ghrelin-28	7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.27	Single	7X9B	Neuropeptide Y	7X9B-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2
27.27	Single	8HCQ	Endothelin-1	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.27	Single	8HCX	Endothelin-1	8HCX-ET_B-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
27.27	Consensus	eta_on	Orthosteric Ligand	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.27	Consensus	gq_class-a	Orthosteric Ligand	gq_amine gq_peptide
26.92	Single	7SK6	CXCL12_LRHQ	7SK6-ACKR3-CXCL12_LRHQ
26.67	Single	4JKV	Taladegib (LY2940680)	4JKV-SMO-Taladegib (LY2940680)
26.67	Single	5IUA	Q27456348	5IUA-A_2A-Q27456348-Na
26.67	Single	5N2R	PubChem 92460631; psb36	5N2R-A_2A-PubChem 92460631; psb36-Na
26.67	Single	5N2S	PSB36	5N2S-A₁-PSB36
26.67	Single	6LPL	ZM241385	6LPL-A_2A-ZM241385-Na
26.67	Single	6S0Q	ZM241385	6S0Q-A_2A-ZM241385
26.67	Single	6WQA	ZM241385	6WQA-A_2A-ZM241385-Na
26.67	Single	7RM5	ZM241385	7RM5-A_2A-ZM241385-Na
26.67	Single	7T9N	PubChem 644078	7T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
26.67	Single	7Y26	Octreotide	7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.67	Single	7Y27	Somatostatin-14	7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.67	Single	8FYN	ZM241385	8FYN-A_2A-ZM241385-Na
26.67	Single	8GNE	KW-6356	8GNE-A_2A-KW-6356-Na
26.67	Single	8QOT	Nanobody E	8QOT-μ-Nanobody E
26.67	Consensus	gs_sst	Orthosteric Ligand	7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.32	Single	5VBL	Apelin Mimetic Peptide Agonist	5VBL-Apelin-Apelin Mimetic Peptide Agonist
26.32	Single	7RMH	Substance P	7RMH-NK₁-Substance P-Gs/&β;1/&γ;2
26.32	Single	7VLA	CCL15(27-92)	7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
26.32	Single	7WIC	Somatostatin-14	7WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
26.32	Single	8JZZ	C5a-desArg	8JZZ-C5a₁-C5a-desArg-Go/&β;1/&γ;2
26.32	Consensus	gi_ghrelin	Orthosteric Ligand	7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
26.32	Consensus	protein_off	Orthosteric Ligand	ccr_off chemokine_off gnrh_off
26.32	Consensus	sst2_on	Orthosteric Ligand	7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
26.09	Single	7SK3	CXCL12	7SK3-ACKR3-CXCL12
26.09	Single	7SK4	CXCL12_LRHQ	7SK4-ACKR3-CXCL12_LRHQ
26.09	Consensus	bradykinin_on	Orthosteric Ligand	bk2_on bk1_on
26.09	Consensus	ccr5_on	Orthosteric Ligand	7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
26.09	Consensus	npy2_on	Orthosteric Ligand	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y₂-Peptide YY(3-36)-Gi1/&β;1/&γ;2
25.93	Single	6LRY	Sarafotoxin-B	6LRY-ET_B-Sarafotoxin-B
25.00	Single	5V56	TC114	5V56-SMO-TC114
25.00	Single	5V57	TC114	5V57-SMO-TC114
25.00	Single	5XJM	(Sar1,Ile8)-Angiotensin II	5XJM-AT₂-(Sar1,Ile8)-Angiotensin II
25.00	Single	6DO1	Angiotensin-Like peptide S1I8	6DO1-AT₁-Angiotensin-Like peptide S1I8
25.00	Single	7F1Q	MIP-1a	7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
25.00	Single	7F1T	MIP-1a	7F1T-CCR5-MIP-1a
25.00	Single	7SK5	CXCL12	7SK5-ACKR3-CXCL12
25.00	Single	7UL2	SR48692	7UL2-NTS₁-SR48692-Na
25.00	Single	7VDH	C48/80	7VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
25.00	Single	7XJL	Spexin	7XJL-GAL₂-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00	Single	7XMS	Somatostatin-14	7XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
25.00	Single	7XOW	Gastrin	7XOW-CCK_B-Gastrin-Gq/&β;1/&γ;2
25.00	Single	7XOX	Cholecystokinin-8	7XOX-CCK_B-Cholecystokinin-8-Gq/&β;1/&γ;2
25.00	Single	7XWO	Neurokinin-A	7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00	Single	7YOO	Neuropeptide Y	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2
25.00	Single	8HQC	C5a anaphylatoxin	8HQC-C5a₁-C5a anaphylatoxin-Go/&β;1/&γ;2
25.00	Single	8I9A	EP54	8I9A-C3a_B-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00	Single	8ID3	9-Hydroxystearic acid	8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
25.00	Single	8ID6	Oleic acid	8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
25.00	Consensus	arrestin2	Orthosteric Ligand	6TKO-β₁-Arformoterol-Arrestin2 6PWC-NTS₁-Neurotensin-Arrestin2 7R0C-V₂-Acyclovir triphosphate-Arrestin2
25.00	Consensus	cck_on	Orthosteric Ligand	ccka_on cckb_on
25.00	Consensus	ccr_on	Orthosteric Ligand	ccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
25.00	Consensus	etb_on	Orthosteric Ligand	8HCX-ET_B-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ET_B-IRL1620-Gi1/&β;1/&γ;2
25.00	Consensus	gi_cck	Orthosteric Ligand	7EZH-CCK_A-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCK_B-Gastrin-17-Gi2/&β;1/&γ;2
25.00	Consensus	gi_protein	Orthosteric Ligand	gi_chemokine gi_chemerin
25.00	Consensus	gs_compl-peptide	Orthosteric Ligand	8I9A-C3a_B-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00	Consensus	m4_on_allo	Other Ligand	7TRP-M₄-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M₄-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M₄-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
25.00	Consensus	nts1_off_allo	Orthosteric Ligand	7UL2-NTS₁-SR48692-Na
25.00	Consensus	nts1_on_allo	Orthosteric Ligand	8JPB-NTS₁-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
25.00	Consensus	smo_on_allo	Orthosteric Ligand	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
24.00	Single	6IGL	IRL1620	6IGL-ET_B-IRL1620
24.00	Consensus	gq_bradykinin	Orthosteric Ligand	7F6H-BK₂-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK₂-Kallidin-Gq/&β;1/&γ;2
24.00	Consensus	gq_peptide	Orthosteric Ligand	gq_cck gq_angiotensin gq_bombesin gq_bradykinin
24.00	Consensus	gs_endothelin	Orthosteric Ligand	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ET_B-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
24.00	Consensus	gs_peptide	Orthosteric Ligand	gs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
24.00	Consensus	peptide_on	Orthosteric Ligand	opioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
23.81	Single	7W55	Neuromedin-U-25	7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.81	Single	7XA3	CCL2	7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
23.81	Consensus	angiotensin_on	Orthosteric Ligand	at1_on
23.81	Consensus	at1_on	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/&β;1/&γ;2
23.81	Consensus	ccr2_on	Orthosteric Ligand	7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
23.81	Consensus	ccr_off	Orthosteric Ligand	ccr5_off ccr8_off
23.81	Consensus	gs_tachykinin	Orthosteric Ligand	8U26-NK₁-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK₁-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.81	Consensus	opioid_on	Orthosteric Ligand	kop_on mop_on nop_on dop_on
23.81	Consensus	tachykinin_on	Orthosteric Ligand	nk1_on nk2_on
23.53	Single	3VW7	Vorapaxar; Na	3VW7-PAR1-Vorapaxar; Na
23.53	Single	4PY0	2MeSATP	4PY0-P2Y₁₂-2MeSATP
23.53	Single	7WQ4	Galanin	7WQ4-GAL₂-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.53	Single	7XW5	ML109	7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
23.53	Single	7Y24	Octreotide	7Y24-SST2-Octreotide-Go/&β;1/&γ;2
23.53	Single	7Y66	BM213	7Y66-C5a₁-BM213-Gi1/&β;1/&γ;2
23.53	Single	8DWC	Proenkephalin-A	8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.53	Single	8H0Q	Gastrin Releasing Peptide	8H0Q-BB₂-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.53	Single	8HK2	C3a anaphylatoxin	8HK2-C3a_B-C3a anaphylatoxin-Gi1/&β;1/&γ;2
23.53	Consensus	dp2_off	Orthosteric Ligand	6D27-DP₂-CAY10471 6D26-DP₂-Fevipiprant
23.53	Consensus	dp_off	Orthosteric Ligand	dp2_off
23.53	Consensus	tsh_on_allo	Other Ligand	7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
23.08	Single	3VG9	ZM241385	3VG9-A_2A-ZM241385-Antibody
23.08	Single	5K2D	ZM241385	5K2D-A_2A-ZM241385
23.08	Single	6IGK	Endothelin-3	6IGK-ET_B-Endothelin-3
23.08	Single	6JZH	ZM241385	6JZH-A_2A-ZM241385-Na
23.08	Single	6PS7	ZM241385	6PS7-A_2A-ZM241385-Na
23.08	Single	7BR3	Elagolix	7BR3-GnRH₁-Elagolix
23.08	Single	7F8U	Lintitript	7F8U-CCK_A-Lintitript
23.08	Single	7F8Y	Devazepide	7F8Y-CCK_A-Devazepide
23.08	Single	7VV5	C48/80	7VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
23.08	Single	7W0M	PubChem 122701908	7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
23.08	Single	7W0O	Elabela	7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
23.08	Single	7X2C	Fenoldopam	7X2C-D₁-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
23.08	Single	8GNG	Istradefylline	8GNG-A_2A-Istradefylline
23.08	Consensus	gi_peptide	Orthosteric Ligand	gi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
23.08	Consensus	gnrh1_off	Orthosteric Ligand	7BR3-GnRH₁-Elagolix
22.73	Single	6JOD	Angiotensin II	6JOD-AT₂-Angiotensin II
22.73	Single	7F6G	SAR1-AngII	7F6G-AT₁-SAR1-AngII-Gq/&β;1/&γ;2
22.73	Single	8HNK	CXCL11	8HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
22.73	Consensus	ccr1_on	Orthosteric Ligand	7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
22.73	Consensus	compl-peptide_on	Orthosteric Ligand	c5a1_on c3a_on
22.73	Consensus	gq_angiotensin	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/&β;1/&γ;2
22.73	Consensus	nmur2_on	Orthosteric Ligand	7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.73	Consensus	nmur_on	Orthosteric Ligand	nmur1_on nmur2_on
22.22	Single	4PXZ	2MeSADP	4PXZ-P2Y₁₂-2MeSADP
22.22	Single	6M1H	Maxadilan	6M1H-PAC₁-Maxadilan-Gs/&β;1/&γ;2
22.22	Single	7EZC	UKA	7EZC-A_2A-UKA
22.22	Single	7EZH	Cholecystokinin-8	7EZH-CCK_A-Cholecystokinin-8-Gi1/&β;1/&γ;2
22.22	Single	7EZM	Cholecystokinin-8	7EZM-CCK_A-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
22.22	Single	7P00	Substance P	7P00-NK₁-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.22	Single	8HBD	IRL1620	8HBD-ET_B-IRL1620-Gi1/&β;1/&γ;2
22.22	Single	8HN1	Toxin AdTx1	8HN1-Alpha1A-Toxin AdTx1
22.22	Single	8IYS	TUG-891	8IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
22.22	Consensus	c5a1_off_ortoallo	Orthosteric Ligand	6C1Q-C5a₁-PMX53-NDT9513727 6C1R-C5a₁-PMX53-Avacopan; Na
22.22	Consensus	cckb_on	Orthosteric Ligand	7XOW-CCK_B-Gastrin-Gq/&β;1/&γ;2 7F8W-CCK_B-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
22.22	Consensus	gal2_on	Orthosteric Ligand	7WQ4-GAL₂-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL₂-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.22	Consensus	gi_endothelin	Orthosteric Ligand	8IY5-ET_B-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ET_B-IRL1620-Gi1/&β;1/&γ;2
22.22	Consensus	gs_cck	Orthosteric Ligand	7MBX-CCK_A-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCK_A-SR146131-Gs/&β;1/&γ;2
22.22	Consensus	gs_galanin	Orthosteric Ligand	7WQ4-GAL₂-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL₂-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.22	Consensus	nk2_on	Orthosteric Ligand	7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.74	Single	7P02	Protachykinin-1	7P02-NK₁-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
21.74	Single	7VL9	CCL15(26-92)	7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
21.74	Single	7X9C	Pancreatic Hormone	7X9C-Y₄-Pancreatic Hormone-Gi1/&β;1/&γ;2
21.74	Single	7Y64	C5a anaphylatoxin	7Y64-C5a₁-C5a anaphylatoxin-Gi1/&β;1/&γ;2
21.74	Consensus	gs_bradykinin	Orthosteric Ligand	7F2O-BK₂-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK₁-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.74	Consensus	gs_ghrelin	Orthosteric Ligand	7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.74	Consensus	gs_neuromedin	Orthosteric Ligand	7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.43	Single	5IU4	ZM241385	5IU4-A_2A-ZM241385-Na
21.43	Single	5IU7	Q27456346	5IU7-A_2A-Q27456346-Na
21.43	Single	5IUB	Q27456344	5IUB-A_2A-Q27456344-Na
21.43	Single	5JTB	ZM241385	5JTB-A_2A-ZM241385
21.43	Single	5K2C	ZM241385	5K2C-A_2A-ZM241385-Na
21.43	Single	5NM4	ZM241385	5NM4-A_2A-ZM241385-Na
21.43	Single	6MH8	ZM241385	6MH8-A_2A-ZM241385
21.43	Single	6WJC	Muscarinic toxin 7	6WJC-M₁-Atropine-Muscarinic toxin 7
21.43	Single	6ZA8	RTI-3a	6ZA8-NTS₁-RTI-3a
21.43	Single	6ZDR	HMS1413f12	6ZDR-A_2A-HMS1413f12-Na
21.43	Single	6ZIN	SR48692	6ZIN-NTS₁-SR48692
21.43	Single	7ARO	LUF5833	7ARO-A_2A-LUF5833-Na
21.43	Single	7C2E	PubChem 149050799	7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
21.43	Single	7T32	ZM241385	7T32-A_2A-ZM241385
21.43	Single	7TRQ	VU0467154	7TRQ-M₄-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
21.43	Single	7VV6	C48/80	7VV6-MRGPRX2-C48/80
21.43	Single	7XOV	SR146131	7XOV-CCK_A-SR146131-Gs/&β;1/&γ;2
21.43	Single	8U1U	CCL1	8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
21.43	Consensus	m1_off_allo	Other Ligand	6WJC-M₁-Atropine-Muscarinic toxin 7
21.05	Single	5WF6	UK-432097	5WF6-A_2A-UK-432097
21.05	Single	7F8W	Gastrin-17	7F8W-CCK_B-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
21.05	Single	7RKN	Fractalkine	7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
21.05	Single	7RMG	Substance P	7RMG-NK₁-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
21.05	Single	7X8S	WB4-24	7X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
21.05	Single	7Y1F	Dynorphin	7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
21.05	Single	7YJ4	INSL5	7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
21.05	Single	8IA7	Cholecystokinin-8	8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
21.05	Single	8JBF	Senktide	8JBF-NK₃-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.05	Single	8SAI	1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine	8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
21.05	Consensus	c3a_on	Orthosteric Ligand	8HK2-C3a_B-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3a_B-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3a_B-EP141-Go/&β;1/&γ;2 8I95-C3a_B-EP54-Go/&β;1/&γ;2
21.05	Consensus	gi_apelin	Orthosteric Ligand	7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
21.05	Consensus	go_compl-peptide	Orthosteric Ligand	8I95-C3a_B-EP54-Go/&β;1/&γ;2 8IA2-C5a₁-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3a_B-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3a_B-EP141-Go/&β;1/&γ;2
21.05	Consensus	gq_cck	Orthosteric Ligand	8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCK_B-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCK_A-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCK_B-Gastrin-Gq/&β;1/&γ;2
21.05	Consensus	gs_bombesin	Orthosteric Ligand	8H0Q-BB₂-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB₁-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.05	Consensus	ox2_on	Orthosteric Ligand	7L1V-OX₂-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX₂-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX₂-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
20.83	Single	5UIW	5P7-CCL5	5UIW-CCR5-5P7-CCL5
20.83	Single	7F8V	Gastrin-17	7F8V-CCK_B-Gastrin-17-Gi2/&β;1/&γ;2
20.83	Single	7W57	Neuromedin-S	7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.83	Consensus	ccr5_off	Orthosteric Ligand	5UIW-CCR5-5P7-CCL5
20.83	Consensus	gi_compl-peptide	Orthosteric Ligand	8HK5-C5a₁-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3a_B-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a₁-BM213-Gi1/&β;1/&γ;2 7Y67-C5a₁-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3a_B-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a₁-C5a peptide-Gi1/&β;1/&γ;2
20.83	Consensus	gi_neuromedin	Orthosteric Ligand	7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
20.83	Consensus	kop_on	Orthosteric Ligand	8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
20.83	Consensus	npy4_on	Orthosteric Ligand	7X9C-Y₄-Pancreatic Hormone-Gi1/&β;1/&γ;2
20.69	Single	7X9A	Neuropeptide Y	7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
20.69	Consensus	gi_neuropeptide	Orthosteric Ligand	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y₂-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y₄-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
20.69	Consensus	npy1_on	Orthosteric Ligand	7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
20.69	Consensus	npy_on	Orthosteric Ligand	npy2_on npy4_on npy1_on
20.00	Single	4EIY	ZM241385	4EIY-A_2A-ZM241385-Na
20.00	Single	5IU8	Q27456347	5IU8-A_2A-Q27456347-Na
20.00	Single	5OLG	ZM241385	5OLG-A_2A-ZM241385-Na
20.00	Single	6D27	CAY10471	6D27-DP₂-CAY10471
20.00	Single	6FKC	PubChem 132473039	6FKC-Rhodopsin-PubChem 132473039
20.00	Single	6XBM	25(S)-Epoxycholesterol	6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
20.00	Single	7CFM	P395	7CFM-GPBA-P395-Gs/&β;1/&γ;2
20.00	Single	7F54	Afamelanotide	7F54-MC₄-Afamelanotide-Gs/&β;1/&γ;2
20.00	Single	7F8X	NN9056	7F8X-CCK_A-NN9056
20.00	Single	7LCI	Danuglipron	7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
20.00	Single	7LCK	Danuglipron	7LCK-GLP-1-Danuglipron
20.00	Single	7NA8	PubChem 178024	7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
20.00	Single	7PYR	PSB-2115	7PYR-A_2A-PSB-2115
20.00	Single	7S15	PubChem 134611223	7S15-GLP-1-PubChem 134611223
20.00	Single	7W0P	Elabela	7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
20.00	Single	7W53	Neuromedin-U-25	7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00	Single	7XK8	Neuromedin-U-25	7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
20.00	Single	7XMR	Somatostatin-14	7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
20.00	Single	7YU4	ONO-0740556	7YU4-LPA₁-ONO-0740556
20.00	Single	8F7X	Nociceptin	8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
20.00	Single	8HQM	NPGLY	8HQM-GPR132-NPGLY-Gi1/&β;1/&γ;2
20.00	Single	8U4O	CXCL12	8U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
20.00	Consensus	a2_off	Orthosteric Ligand	a2a_off
20.00	Consensus	a2a_off	Orthosteric Ligand	8C9W-A_2A-Etrumadenant 3UZA-A_2A-GTPL9236 8GNG-A_2A-Istradefylline 5UIG-A_2A-J3.651.884G 8CU6-A_2A-LJ-4517 7PX4-A_2A-PSB-2113 7PYR-A_2A-PSB-2115 8DU3-A_2A-PubChem 105526064 8JWY-A_2A-PubChem 168451710 5K2D-A_2A-ZM241385
20.00	Consensus	alpha1a_off	Orthosteric Ligand	7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
20.00	Consensus	apelin_on	Orthosteric Ligand	7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
20.00	Consensus	cck_off	Orthosteric Ligand	ccka_off
20.00	Consensus	ccka_off	Orthosteric Ligand	7F8Y-CCK_A-Devazepide 7F8U-CCK_A-Lintitript
20.00	Consensus	ccr8_on	Orthosteric Ligand	8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
20.00	Consensus	endothelin_on	Orthosteric Ligand	etb_on eta_on
20.00	Consensus	ffa_on	Orthosteric Ligand	ffa4_on ffa1_on ffa2_on ffa3_on
20.00	Consensus	fpr-alx_on	Orthosteric Ligand	fpr1-alx_on fpr2-alx_on
20.00	Consensus	fsh_on_allo	Other Ligand	8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
20.00	Consensus	gi_relaxin	Orthosteric Ligand	7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
20.00	Consensus	nop_on	Orthosteric Ligand	8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
19.23	Single	8FEG	PRD_002517	8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
19.05	Single	3QAK	UK-432097	3QAK-A_2A-UK-432097
19.05	Single	7EZK	Cholecystokinin-8	7EZK-CCK_A-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
19.05	Single	7RKM	Fractalkine	7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
19.05	Single	7RMI	Substance P	7RMI-NK₁-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
19.05	Single	7W0N	Elabela	7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
19.05	Single	7WJ5	Somatostatin-14	7WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
19.05	Single	8DWG	Proenkephalin-A	8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
19.05	Single	8F7Q	Beta-endorphin	8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
19.05	Single	8F7W	Dynorphin	8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
19.05	Consensus	alpha1_off	Orthosteric Ligand	alpha1a_off alpha1b_off
19.05	Consensus	cx3cr_on	Orthosteric Ligand	cx3cr1_on
18.75	Single	5NM2	ZM241385	5NM2-A_2A-ZM241385-Na
18.75	Single	5ZBQ	UR-MK-299	5ZBQ-Y₁-UR-MK-299
18.75	Single	6RZ5	Zafirlukast	6RZ5-CysLT₁-Zafirlukast-Na
18.75	Single	6XBK	Cholesterol	6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
18.75	Single	6Z4S	SR48692	6Z4S-NTS₁-SR48692
18.75	Single	7BB7	Acyclovir triphosphate	7BB7-V₂-Acyclovir triphosphate-Gs/&β;1/&γ;2
18.75	Single	7VUH	JNJ-63533054	7VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
18.75	Single	7YU3	ONO-0740556	7YU3-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
18.75	Single	7YU6	ONO-0740556	7YU6-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
18.75	Single	7YU7	ONO-0740556	7YU7-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
18.75	Single	8ID9	Eicosapentaenoic acid	8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
18.75	Consensus	a1_off	Orthosteric Ligand	5UEN-A₁-DU172 5N2S-A₁-PSB36
18.18	Single	5WF5	UK-432097	5WF5-A_2A-UK-432097
18.18	Single	6LW5	WKYMVm	6LW5-FPR2-ALX-WKYMVm
18.18	Single	6XBM	25(S)-Epoxycholesterol	6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
18.18	Single	7MBX	Cholecystokinin-8	7MBX-CCK_A-Cholecystokinin-8-Gs/&β;1/&γ;1
18.18	Single	7XAU	Octreotide	7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
18.18	Single	7XNA	CYN154806	7XNA-SST2-CYN154806
18.18	Single	7XOU	Cholecystokinin-8	7XOU-CCK_A-Cholecystokinin-8-Gs/&β;1/&γ;2
18.18	Single	8A2O	Theophylline	8A2O-A_2A-Theophylline-Na
18.18	Single	8HVI	NOX-6-7	8HVI-GPR132-NOX-6-7-Gi1/&β;1/&γ;2
18.18	Single	8U4Q	REGN7663-Fab	8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/&β;1/&γ;2
18.18	Single	8XZG	Apelin-13	8XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
18.18	Single	8XZH	MM07	8XZH-Apelin-MM07-Gi1/&β;1/&γ;2
18.18	Consensus	cx3cr1_on	Orthosteric Ligand	7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
18.18	Consensus	gi_formylpeptide	Orthosteric Ligand	7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
18.18	Consensus	gs_class-a	Orthosteric Ligand	gs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
18.18	Consensus	sst2_off	Orthosteric Ligand	7XNA-SST2-CYN154806
17.86	Consensus	melanocortin_on	Orthosteric Ligand	mc2_on mc1_on mc3_on mc4_on mc5_on
17.65	Single	4IAQ	Dihydroergotamine	4IAQ-5-HT_1B-Dihydroergotamine
17.65	Single	4RWD	DIPP-NH2	4RWD-δ-DIPP-NH2-Na
17.65	Single	4Z34	ONO-9780307	4Z34-LPA₁-ONO-9780307
17.65	Single	7F58	THIQ	7F58-MC₄-THIQ-Gs/&β;1/&γ;2
17.65	Single	7PX4	PSB-2113	7PX4-A_2A-PSB-2113
17.65	Single	7WVX	Humanin	7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
17.65	Single	7XTQ	R399	7XTQ-GPBA-R399-Gs/&β;1/&γ;2
17.65	Single	7Y67	C089 peptide	7Y67-C5a₁-C089 peptide-Gi1/&β;1/&γ;2
17.65	Single	7YU5	ONO-0740556	7YU5-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
17.65	Single	8HPT	C5a anaphylatoxin C-terminal peptide	8HPT-C5a₁-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
17.65	Single	8I2G	Compound 716340	8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
17.65	Single	8X16	Piclidenoson	8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
17.65	Single	8XBI	S3E-LysoPS	8XBI-GPR34-S3E-LysoPS
17.65	Consensus	5ht1b_on	Orthosteric Ligand	6G79-5-HT_1B-Donitriptan-Go/&β;1/&γ;2
17.65	Consensus	adenosine_off	Orthosteric Ligand	a1_off a2_off
17.65	Consensus	ccka_on	Orthosteric Ligand	7EZH-CCK_A-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCK_A-SR146131-Gs/&β;1/&γ;2
17.65	Consensus	chemerin_on	Orthosteric Ligand	cml1_on
17.65	Consensus	class-a_off	Orthosteric Ligand	sensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
17.65	Consensus	cml1_on	Orthosteric Ligand	8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
17.65	Consensus	cyslt1_off_ortoallo	Orthosteric Ligand	6RZ5-CysLT₁-Zafirlukast-Na 6RZ4-CysLT₁-Pranlukast-Na
17.65	Consensus	ffa4_on	Orthosteric Ligand	8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
17.65	Consensus	gi_ffa	Orthosteric Ligand	8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
17.65	Consensus	lpa1_on	Orthosteric Ligand	7TD0-LPA₁-LPA-Gi1/&β;1/&γ;2 7YU3-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
17.65	Consensus	lpa_off	Orthosteric Ligand	lpa1_off
17.65	Consensus	lpa_on	Orthosteric Ligand	lpa1_on
17.65	Consensus	npy1_off	Orthosteric Ligand	5ZBH-Y₁-BMS-193885 5ZBQ-Y₁-UR-MK-299
17.39	Single	5WB2	CX3CL1.35	5WB2-US28-CX3CL1.35
17.39	Single	5YQZ	Glucagon analogue	5YQZ-Glucagon-Glucagon analogue
17.39	Single	6MEO	Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4	6MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
17.39	Single	6MET	Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4	6MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
17.39	Single	8H4K	GW9508	8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.39	Single	8HA0	PTH	8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
17.39	Single	8XZJ	WN353	8XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
17.39	Consensus	gi_somatostatin	Orthosteric Ligand	7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
17.39	Consensus	go_class-b	Orthosteric Ligand	go_class-b1 go_class-b2
16.67	Single	6C1R	PMX53	6C1R-C5a₁-PMX53-Avacopan; Na
16.67	Single	6KPG	AM841	6KPG-CB₁-AM841-Gi1/&β;1/&γ;2
16.67	Single	6LI0	GTPL9804	6LI0-GPR52-GTPL9804
16.67	Single	6X18	GLP-1	6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
16.67	Single	7LLY	Oxyntomodulin	7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
16.67	Single	7SUS	PubChem 122701908	7SUS-Apelin-PubChem 122701908
16.67	Single	7W0L	PubChem 122701908	7W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
16.67	Single	7W0N	Elabela	7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
16.67	Single	7X1T	Taltirelin	7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67	Single	7XAT	Somatostatin-14	7XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
16.67	Single	7XW6	ML109	7XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
16.67	Single	7XXI	2MeSADP	7XXI-P2Y₁₂-2MeSADP-Gi2/&β;1/&γ;2
16.67	Single	7Y35	Abaloparatide	7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
16.67	Single	7YKD	Chemerin-9	7YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
16.67	Single	8E3Y	PACAP27	8E3Y-VPAC₁-PACAP27-Gs/&β;1/&γ;2
16.67	Single	8E3Z	VIP	8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2
16.67	Single	8HK5	Complement C5	8HK5-C5a₁-Complement C5-Gi1/&β;1/&γ;2
16.67	Single	8I9L	C3a anaphylatoxin	8I9L-C3a_B-C3a anaphylatoxin-Go/&β;1/&γ;2
16.67	Single	8JGF	BAM8-22	8JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67	Single	8JRV	Glucagon	8JRV-Glucagon-Glucagon-Arrestin2
16.67	Single	8T3Q	DHA	8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67	Consensus	c5a1_on	Orthosteric Ligand	7Y65-C5a₁-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a₁-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a₁-BM213-Gi1/&β;1/&γ;2 7Y67-C5a₁-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/&β;1/&γ;2
16.67	Consensus	gs_bileacid	Orthosteric Ligand	7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
16.67	Consensus	gs_melanocortin	Orthosteric Ligand	7F4D-MC₁-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC₄-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC₄-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC₄-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC₄-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC₄-THIQ-Gs/&β;1/&γ;2
16.67	Consensus	gs_steroid	Orthosteric Ligand	gs_bileacid
16.67	Consensus	lpa1_off	Orthosteric Ligand	4Z36-LPA₁-ONO-3080573 4Z34-LPA₁-ONO-9780307 4Z35-LPA₁-ONO-9910539 7YU4-LPA₁-ONO-0740556
16.67	Consensus	m4_on	Orthosteric Ligand	7TRS-M₄-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M₄-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M₄-PubChem 9864275-Gi1/&β;1/&γ;2
16.67	Consensus	mc2_on	Orthosteric Ligand	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
16.67	Consensus	nts1_off	Orthosteric Ligand	6Z4Q-NTS₁-SR142948A 6Z4S-NTS₁-SR48692
16.67	Consensus	nts_off	Orthosteric Ligand	nts1_off
16.00	Single	4XT3	Fractalkine	4XT3-US28-Fractalkine
16.00	Single	6FJ3	PTH	6FJ3-PTH1-PTH
16.00	Single	6NBF	Long-acting PTH analog	6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
16.00	Single	6NBI	Long-acting PTH analog	6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
16.00	Single	7RGP	Tirzepatide	7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
16.00	Single	7W3Z	Gastrin Releasing Peptide	7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
16.00	Single	8E3X	PACAP27	8E3X-PAC₁-PACAP27-Gs/&β;1/&γ;2
16.00	Single	8FLR	PTHrP(1-36)	8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
16.00	Single	8H0P	NMB30	8H0P-BB₁-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.00	Single	8HAO	PTH	8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
16.00	Single	8JIS	Peptide-15	8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
16.00	Consensus	bb1_on	Orthosteric Ligand	8H0P-BB₁-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.00	Consensus	ctlike_on	Orthosteric Ligand	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
16.00	Consensus	glp1_on_allo	Orthosteric Ligand	6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
15.79	Single	4NC3	Ergotamine	4NC3-5-HT_2B-Ergotamine
15.79	Single	4Z35	ONO-9910539	4Z35-LPA₁-ONO-9910539
15.79	Single	6BQG	Ergotamine	6BQG-5-HT_2C-Ergotamine
15.79	Single	6G79	Donitriptan	6G79-5-HT_1B-Donitriptan-Go/&β;1/&γ;2
15.79	Single	7LLL	Exendin-4	7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
15.79	Single	7MBY	Cholecystokinin-8	7MBY-CCK_A-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
15.79	Single	7WVV	fMLFII	7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
15.79	Single	7X8R	BOC5	7X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
15.79	Single	7XJI	Solabegron	7XJI-β₃-Solabegron-Gs/&β;1/&γ;2
15.79	Single	7Y65	C5a peptide	7Y65-C5a₁-C5a peptide-Gi1/&β;1/&γ;2
15.79	Single	7YU8	ONO-0740556	7YU8-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
15.79	Consensus	bileacid_on	Orthosteric Ligand	7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
15.79	Consensus	class-a_on	Orthosteric Ligand	sensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
15.79	Consensus	gi_class-a	Orthosteric Ligand	gi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
15.79	Consensus	gs_orexin	Orthosteric Ligand	7L1U-OX₂-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX₂-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX₂-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
15.79	Consensus	orexin_on	Orthosteric Ligand	ox2_on
15.79	Consensus	steroid_on	Orthosteric Ligand	bileacid_on
15.62	Consensus	ct_on	Orthosteric Ligand	7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
15.38	Single	6VCB	GLP-1	6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
15.38	Single	7F53	Alpha-MSH	7F53-MC₄-Alpha-MSH-Gs/&β;1/&γ;2
15.38	Single	7S1M	Ex4-D-Ala	7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
15.38	Single	7VUI	JNJ-63533054	7VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
15.38	Single	7VVJ	PTHrP(1-36)	7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
15.38	Single	7WVY	Amyloid-Beta42	7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
15.38	Single	7XP6	Strychnine	7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
15.38	Single	8FX5	Xanomeline	8FX5-M₄-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
15.38	Single	8H8J	Lodoxamide	8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/&β;1/&γ;2
15.38	Single	8U4R	REGN7663-Fab	8U4R-CXCR4-REGN7663-Fab-Cholesterol
15.38	Consensus	class-t_on	Orthosteric Ligand	taste2_on
15.38	Consensus	gs_class-t	Orthosteric Ligand	gs_taste
15.38	Consensus	gs_taste	Orthosteric Ligand	7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
15.38	Consensus	taste2_on	Orthosteric Ligand	7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
15.00	Single	4UG2	CGS21680	4UG2-A_2A-CGS21680
15.00	Single	6C1Q	PMX53	6C1Q-C5a₁-PMX53-NDT9513727
15.00	Single	6OMM	WKYMVX	6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
15.00	Single	6RZ6	ONO-2570366	6RZ6-CysLT₂-ONO-2570366
15.00	Single	7F9Z	GHRP-6	7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.00	Single	7RKF	Fractalkine	7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
15.00	Single	7X1U	TRH	7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.00	Single	7XN9	L-054,522	7XN9-SST2-L-054,522
15.00	Single	8H4I	Doconexent	8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
15.00	Consensus	dop_on	Orthosteric Ligand	8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
15.00	Consensus	fpr2-alx_on	Orthosteric Ligand	7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
15.00	Consensus	lpl_off	Orthosteric Ligand	s1p_off lpa_off
15.00	Consensus	lpl_on	Orthosteric Ligand	s1p_on lpa_on
15.00	Consensus	mc4_on	Orthosteric Ligand	7F53-MC₄-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC₄-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC₄-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC₄-THIQ-Gs/&β;1/&γ;2 7F54-MC₄-Afamelanotide-Gs/&β;1/&γ;2
14.81	Single	6B3J	Exendin-P5	6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
14.81	Single	6NBH	Long-acting PTH analog	6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
14.81	Single	7KI1	Taspoglutide	7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
14.81	Single	7VGX	Neuropeptide Y	7VGX-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
14.81	Single	7VVK	PTH	7VVK-PTH1-PTH-Gs/&β;1/&γ;2
14.81	Single	7VVL	PTH	7VVL-PTH1-PTH-Gs/&β;1/&γ;2
14.81	Single	8HAF	PTHrP(1-36)	8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
14.81	Consensus	glp1_on	Orthosteric Ligand	6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
14.29	Single	3PWH	ZM241385	3PWH-A_2A-ZM241385
14.29	Single	3VGA	ZM241385	3VGA-A_2A-ZM241385-Antibody
14.29	Single	4IAR	Ergotamine	4IAR-5-HT_1B-Ergotamine
14.29	Single	4XT1	Fractalkine	4XT1-US28-Fractalkine
14.29	Single	5U09	Taranabant	5U09-CB₁-Taranabant
14.29	Single	5VAI	GLP-1	5VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
14.29	Single	6D32	Cyclopamine	6D32-SMO-Cyclopamine-Cyclopamine
14.29	Single	6D35	Cholesterol	6D35-SMO-Cholesterol
14.29	Single	6N51	Quisqualate	6N51-mGlu5; mGlu5-Quisqualate
14.29	Single	6N51	Quisqualate	6N51-mGlu5; mGlu5-Quisqualate
14.29	Single	6UO8	SKF97541	6UO8-GABA_B1, GABA_B2-SKF97541-GS39783
14.29	Single	6UO9	SKF97541	6UO9-GABA_B1, GABA_B2-SKF97541
14.29	Single	6W2X	PubChem 5311042	6W2X-GABA_B1, GABA_B2-PubChem 5311042-PubChem 23727970
14.29	Single	6W2Y	PubChem 5311042	6W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
14.29	Single	6W2Y	PubChem 5311042	6W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
14.29	Single	6WIV	PubChem 52923113; PubChem 52924645	6WIV-GABA_B1, GABA_B2-PubChem 52923113; PubChem 52924645
14.29	Single	7C7Q	Baclofen	7C7Q-GABA_B1, GABA_B2-Baclofen-PubChem 7023848
14.29	Single	7C7S	CGP54626	7C7S-GABA_B1, GABA_B2-CGP54626
14.29	Single	7CUM	CGP54626	7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid
14.29	Single	7DD5	Ca3	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
14.29	Single	7DD5	Ca	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
14.29	Single	7DD5	Ca; Ca; Tryptophan; NPS-2143	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
14.29	Single	7DD5	Ca; Ca; Tryptophan; NPS-2143	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
14.29	Single	7DGE	Quisqualate	7DGE-mGlu1; mGlu1-Quisqualate
14.29	Single	7DTT	Ca	7DTT-CaS-Ca-Ca
14.29	Single	7DTT	Ca	7DTT-CaS-Ca-Ca
14.29	Single	7DTU	Tryptophan	7DTU-CaS-Tryptophan
14.29	Single	7DTU	Tryptophan	7DTU-CaS-Tryptophan
14.29	Single	7DTV	Ca	7DTV-CaS-Ca-Ca; Tryptophan
14.29	Single	7DTV	Ca; Tryptophan	7DTV-CaS-Ca-Ca; Tryptophan
14.29	Single	7DTV	Ca	7DTV-CaS-Ca-Ca; Tryptophan
14.29	Single	7DTV	Ca; Tryptophan	7DTV-CaS-Ca-Ca; Tryptophan
14.29	Single	7DUQ	GLP-1	7DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
14.29	Single	7E6T	Ca	7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
14.29	Single	7E6T	Ca; Ca; Cyclomethyltryptophan; PO4	7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
14.29	Single	7E6T	Ca	7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
14.29	Single	7E6T	Ca; Ca; Cyclomethyltryptophan; PO4	7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
14.29	Single	7E9G	Eglumetad	7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
14.29	Single	7E9G	Eglumetad	7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
14.29	Single	7E9H	Phosphoserine	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
14.29	Single	7E9H	Phosphoserine	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
14.29	Single	7EB2	Baclofen	7EB2-GABA_B1, GABA_B2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
14.29	Single	7EPB	Eglumetad	7EPB-mGlu2; mGlu2-Eglumetad
14.29	Single	7EPB	Eglumetad	7EPB-mGlu2; mGlu2-Eglumetad
14.29	Single	7FD8	Quisqualate	7FD8-mGlu5; mGlu5-Quisqualate
14.29	Single	7FD8	Quisqualate	7FD8-mGlu5; mGlu5-Quisqualate
14.29	Single	7FD9	LY341495	7FD9-mGlu5; mGlu5-LY341495
14.29	Single	7FD9	LY341495	7FD9-mGlu5; mGlu5-LY341495
14.29	Single	7FIH	hCG	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
14.29	Single	7FII	hCG	7FII-LH-hCG-6fuf
14.29	Single	7LCJ	Danuglipron	7LCJ-GLP-1-Danuglipron
14.29	Single	7M3E	Ca; Ca; Tryptophan; NPS-2143; PO4	7M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
14.29	Single	7M3E	Ca; Ca; Tryptophan; NPS-2143; PO4	7M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
14.29	Single	7M3F	Ca; Ca; Tryptophan; Cinacalcet; PO4	7M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
14.29	Single	7M3F	Ca; Ca; Tryptophan; Cinacalcet; PO4	7M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
14.29	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
14.29	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
14.29	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
14.29	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
14.29	Single	7MTQ	LY341495	7MTQ-mGlu2; mGlu2-LY341495
14.29	Single	7MTQ	LY341495	7MTQ-mGlu2; mGlu2-LY341495
14.29	Single	7MTR	Glutamate	7MTR-mGlu2; mGlu2-Glutamate-ADX55164
14.29	Single	7MTR	Glutamate	7MTR-mGlu2; mGlu2-Glutamate-ADX55164
14.29	Single	7MTS	Glutamate	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
14.29	Single	7MTS	Glutamate	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
14.29	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
14.29	Single	7SIL	Ca	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
14.29	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
14.29	Single	7SIL	Ca	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
14.29	Single	7SIM	Ca	7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
14.29	Single	7SIM	Ca; Ca; Cyclomethyltryptophan; PO4	7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
14.29	Single	7SIM	Ca	7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
14.29	Single	7SIM	Ca; Ca; Cyclomethyltryptophan; PO4	7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
14.29	Single	7T6U	CGEN-855A	7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
14.29	Single	7T9N	M22 Fab	7T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
14.29	Single	7TUZ	7alpha,25-dihydroxycholesterol	7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
14.29	Single	7VDL	Cortistatin-14	7VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
14.29	Single	7VUJ	JNJ-63533054	7VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
14.29	Single	7WF7	S1P	7WF7-S1P₁-S1P-Gi1/&β;1/&γ;2
14.29	Single	7WI6	LY341495	7WI6-mGlu3; mGlu3-LY341495
14.29	Single	7WI6	LY341495	7WI6-mGlu3; mGlu3-LY341495
14.29	Single	7WI8	LY341495	7WI8-mGlu3; mGlu3-LY341495
14.29	Single	7WI8	LY341495	7WI8-mGlu3; mGlu3-LY341495
14.29	Single	7WIH	LY2794193	7WIH-mGlu3; mGlu3-LY2794193
14.29	Single	7WIH	LY2794193	7WIH-mGlu3; mGlu3-LY2794193
14.29	Single	7WVW	fMYFINILTL	7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
14.29	Single	7XW6	M22 Fab	7XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
14.29	Single	7XW7	K1-70	7XW7-TSH-K1-70
14.29	Single	8DU3	PubChem 105526064	8DU3-A_2A-PubChem 105526064
14.29	Single	8GHV	PubChem 145964903	8GHV-CB₁-PubChem 145964903-Gi1/&β;1/&γ;2
14.29	Single	8HMP	PubChem 69921479	8HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
14.29	Single	8JCU	LY341495	8JCU-mGlu2; mGlu3-LY341495
14.29	Single	8JCU	LY341495	8JCU-mGlu2; mGlu3-LY341495
14.29	Single	8JCV	LY341495	8JCV-mGlu2; mGlu3-LY341495
14.29	Single	8JCV	LY341495	8JCV-mGlu2; mGlu3-LY341495
14.29	Single	8JCW	LY341495	8JCW-mGlu2; mGlu3-LY341495
14.29	Single	8JCW	LY341495	8JCW-mGlu2; mGlu3-LY341495
14.29	Single	8JCX	LY341495	8JCX-mGlu2; mGlu3-LY341495
14.29	Single	8JCX	LY341495	8JCX-mGlu2; mGlu3-LY341495
14.29	Single	8JCY	LY341495	8JCY-mGlu2; mGlu3-LY341495
14.29	Single	8JCY	LY341495	8JCY-mGlu2; mGlu3-LY341495
14.29	Single	8JCZ	LY341495	8JCZ-mGlu2; mGlu3-LY341495
14.29	Single	8JCZ	LY341495	8JCZ-mGlu2; mGlu3-LY341495
14.29	Single	8JD0	Glutamate	8JD0-mGlu2; mGlu3-Glutamate-J9R
14.29	Single	8JD1	Glutamate	8JD1-mGlu2; mGlu3-Glutamate
14.29	Single	8JD1	Glutamate	8JD1-mGlu2; mGlu3-Glutamate
14.29	Single	8JD2	Glutamate	8JD2-mGlu2; mGlu3-Glutamate
14.29	Single	8JD2	Glutamate	8JD2-mGlu2; mGlu3-Glutamate
14.29	Single	8JD3	Glutamate	8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
14.29	Single	8JD3	Glutamate	8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
14.29	Single	8JD4	Glutamate	8JD4-mGlu2; mGlu4-Glutamate
14.29	Single	8JD4	Glutamate	8JD4-mGlu2; mGlu4-Glutamate
14.29	Single	8JD5	Glutamate	8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
14.29	Single	8JD5	Glutamate	8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
14.29	Single	8JD6	Phosphoserine	8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
14.29	Single	8JD6	Phosphoserine	8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
14.29	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
14.29	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
14.29	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
14.29	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
14.29	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
14.29	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
14.29	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
14.29	Single	8SZI	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
14.29	Single	8SZI	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
14.29	Single	8T3S	Butyric acid	8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.29	Single	8T7H	Quisqualate	8T7H-mGlu5; mGlu5-Quisqualate
14.29	Single	8T7H	Quisqualate	8T7H-mGlu5; mGlu5-Quisqualate
14.29	Single	8T8M	Quisqualate	8T8M-mGlu5; mGlu5-Quisqualate
14.29	Single	8T8M	Quisqualate	8T8M-mGlu5; mGlu5-Quisqualate
14.29	Single	8TAO	Quisqualate	8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
14.29	Single	8TAO	Quisqualate	8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
14.29	Single	8WPG	Tryptophan; Cinacalcet; PO4; Ca	8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
14.29	Single	8WPG	Tryptophan; Cinacalcet; PO4; Ca	8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
14.29	Single	8WPU	Tryptophan; Cinacalcet; PO4; Ca	8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.29	Single	8WPU	Tryptophan; Cinacalcet; PO4; Ca	8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.29	Single	8XBH	S3E-LysoPS	8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
14.29	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29	Single	9AXF	Ca	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29	Single	9AXF	Ca	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29	Single	9AYF	Ca	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
14.29	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
14.29	Consensus	a2a_off_allo	Orthosteric Ligand	6ZDR-A_2A-HMS1413f12-Na 6GT3-A_2A-Imaradenant-Na 8CU7-A_2A-LJ-4517-Na 5OLV-A_2A-LUAA41063-Na 5N2R-A_2A-PubChem 92460631; psb36-Na 5MZJ-A_2A-Theophylline-Na 5OLO-A_2A-Tozadenant-Na 5OLH-A_2A-Vipadenant-Na 5NM4-A_2A-ZM241385-Na 8GNE-A_2A-KW-6356-Na 8JWZ-A_2A-AB928-Na 5MZP-A_2A-Caffeine-Na 8CIC-A_2A-Etrumadenant-Na
14.29	Consensus	class-c_off	Orthosteric Ligand	gabab_off mglu_off
14.29	Consensus	class-c_off	Orthosteric Ligand	gabab_off mglu_off
14.29	Consensus	class-c_on	Orthosteric Ligand	gabab_on mglu_on
14.29	Consensus	class-c_on	Orthosteric Ligand	gabab_on mglu_on
14.29	Consensus	fsh_on_allo	Orthosteric Ligand	8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
14.29	Consensus	gabab_off	Orthosteric Ligand	7C7S-GABA_B1, GABA_B2-CGP54626 7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid 6W2X-GABA_B1, GABA_B2-PubChem 5311042-PubChem 23727970
14.29	Consensus	gabab_on	Orthosteric Ligand	7EB2-GABA_B1, GABA_B2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
14.29	Consensus	gi_class-c	Orthosteric Ligand	gi_mglu gi_gaba
14.29	Consensus	gi_class-c	Orthosteric Ligand	gi_mglu gi_gaba
14.29	Consensus	gi_gaba	Orthosteric Ligand	7EB2-GABA_B1, GABA_B2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
14.29	Consensus	gi_mglu	Orthosteric Ligand	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
14.29	Consensus	gi_mglu	Orthosteric Ligand	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
14.29	Consensus	gi_opioid	Orthosteric Ligand	8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
14.29	Consensus	gphr_on	Orthosteric Ligand	lh_on tsh_on
14.29	Consensus	gs_gphr	Orthosteric Ligand	7T9I-TSH-TSH-Gs/&β;1/&γ;2 7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
14.29	Consensus	gs_protein	Orthosteric Ligand	gs_gphr
14.29	Consensus	lh_on	Orthosteric Ligand	7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
14.29	Consensus	lh_on_allo	Orthosteric Ligand	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
14.29	Consensus	mglu2_off	Orthosteric Ligand	7MTQ-mGlu2; mGlu2-LY341495
14.29	Consensus	mglu2_off	Orthosteric Ligand	7MTQ-mGlu2; mGlu2-LY341495
14.29	Consensus	mglu2_on	Orthosteric Ligand	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
14.29	Consensus	mglu2_on	Orthosteric Ligand	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
14.29	Consensus	mglu3_off	Orthosteric Ligand	7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
14.29	Consensus	mglu3_off	Orthosteric Ligand	7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
14.29	Consensus	mglu4_on	Orthosteric Ligand	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
14.29	Consensus	mglu4_on	Orthosteric Ligand	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
14.29	Consensus	mglu5_off	Orthosteric Ligand	7FD9-mGlu5; mGlu5-LY341495
14.29	Consensus	mglu5_off	Orthosteric Ligand	7FD9-mGlu5; mGlu5-LY341495
14.29	Consensus	mglu_off	Orthosteric Ligand	mglu2_off mglu3_off mglu5_off
14.29	Consensus	mglu_off	Orthosteric Ligand	mglu2_off mglu3_off mglu5_off
14.29	Consensus	mglu_on	Orthosteric Ligand	mglu2_on mglu4_on
14.29	Consensus	mglu_on	Orthosteric Ligand	mglu2_on mglu4_on
14.29	Consensus	mop_off	Orthosteric Ligand	7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
14.29	Consensus	nmur1_on	Orthosteric Ligand	7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29	Consensus	smo_off_allo	Other Ligand	6D32-SMO-Cyclopamine-Cyclopamine
14.29	Consensus	sst_on	Orthosteric Ligand	sst2_on sst4_on
14.29	Consensus	tsh_on	Orthosteric Ligand	7T9I-TSH-TSH-Gs/&β;1/&γ;2
14.29	Consensus	tsh_on_allo	Orthosteric Ligand	7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
13.89	Single	8GY7	Corticotropin	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
13.79	Single	7VBH	Peptide-20	7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
13.79	Single	8FLS	Abaloparatide	8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
13.79	Single	8FLU	Long-acting PTH	8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
13.64	Single	4IB4	Ergotamine	4IB4-5-HT_2B-Ergotamine
13.64	Single	7PIV	Setmelanotide	7PIV-MC₄-Setmelanotide-Gs/&β;1/&γ;2
13.64	Single	7VBI	Non-Acylated Tirzepatide	7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
13.64	Single	7W56	Neuromedin-S	7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.64	Single	7XBX	CX3CL1	7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
13.64	Single	8F7S	Deltorphin	8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
13.64	Single	8IOC	Gamma-MSH	8IOC-MC₃-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
13.64	Single	8SG1	Chemerin-9	8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
13.64	Consensus	gi_lpl	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/&β;1/&γ;2 7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P₁-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P₁-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P₃-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P₃-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA₁-LPA-Gi1/&β;1/&γ;2 7YU3-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P₁-PubChem 4077460-Gi1/&β;1/&γ;2
13.64	Consensus	sst_off	Orthosteric Ligand	sst2_off
13.33	Single	3REY	PubChem 5697	3REY-A_2A-PubChem 5697
13.33	Single	6AQF	ZM241385	6AQF-A_2A-ZM241385
13.33	Single	6FK8	PubChem 132473035	6FK8-Rhodopsin-PubChem 132473035
13.33	Single	6PT0	WIN 55212-2	6PT0-CB₂-WIN 55212-2-Gi1/&β;1/&γ;2
13.33	Single	7BB6	Acyclovir triphosphate	7BB6-V₂-Acyclovir triphosphate-Gs/&β;1/&γ;2
13.33	Single	7VVM	PTH	7VVM-PTH1-PTH-Gs/&β;1/&γ;2
13.33	Single	7WVU	fMLF	7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
13.33	Single	8GUR	PubChem 104895	8GUR-CB₂-PubChem 104895-Gi1/&β;1/&γ;2
13.33	Single	8H4L	Doconexent	8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.33	Single	8HQN	9(S)-HODE	8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
13.33	Single	8JIR	SAR425899	8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
13.33	Single	8K4N	VF0	8K4N-GPR34-VF0-Gi1/&β;1/&γ;2
13.33	Consensus	cb1_off	Orthosteric Ligand	5TGZ-CB₁-AM6538 5U09-CB₁-Taranabant
13.33	Consensus	ffa2_on	Orthosteric Ligand	8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
13.33	Consensus	pth1_on	Orthosteric Ligand	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
13.04	Single	6PT2	KGCHM07	6PT2-δ-KGCHM07
13.04	Single	6VN7	PACAP	6VN7-VPAC₁-PACAP-Gs/&β;1/&γ;2
13.04	Single	7F4D	Alpha-MSH	7F4D-MC₁-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
13.04	Single	7F4H	Afamelanotide	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
13.04	Single	7O7F	(6P4)CCL5	7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
13.04	Single	7TD0	LPA	7TD0-LPA₁-LPA-Gi1/&β;1/&γ;2
13.04	Single	7TD2	LPA	7TD2-LPA₁-LPA-Gi1/&β;1/&γ;2
13.04	Single	7VVN	PTH	7VVN-PTH1-PTH-Gs/&β;1/&γ;2
13.04	Consensus	gi_chemerin	Orthosteric Ligand	8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
13.04	Consensus	mc3_on	Orthosteric Ligand	8IOC-MC₃-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
12.90	Single	7Y36	Teriparatide	7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
12.90	Single	8FLQ	PTH	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
12.90	Consensus	gs_glucagon	Orthosteric Ligand	6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
12.90	Consensus	gs_vip-pacap	Orthosteric Ligand	8E3Y-VPAC₁-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC₁-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2 6M1I-PAC₁-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC₁-PACAP-Gs/&β;1/&γ;2
12.50	Single	5TGZ	AM6538	5TGZ-CB₁-AM6538
12.50	Single	5UEN	DU172	5UEN-A₁-DU172
12.50	Single	6E3Y	Calcitonin gene-related peptide-1	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
12.50	Single	6FK7	PubChem 132473034	6FK7-Rhodopsin-PubChem 132473034
12.50	Single	6FKD	PubChem 137349183	6FKD-Rhodopsin-PubChem 137349183
12.50	Single	6M1I	PACAP	6M1I-PAC₁-PACAP-Gs/&β;1/&γ;2
12.50	Single	6WI9	Secretin	6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
12.50	Single	6X1A	Danuglipron	6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
12.50	Single	7C61	Ergotamine	7C61-5-HT_1B-Ergotamine
12.50	Single	7CRH	SKF83959	7CRH-D₁-SKF83959-Gs/&β;1/&γ;2
12.50	Single	7DD6	Ca	7DD6-CaS-Ca-Ca; Ca; Tryptophan
12.50	Single	7DD6	Ca; Ca; Tryptophan	7DD6-CaS-Ca-Ca; Ca; Tryptophan
12.50	Single	7DD6	Ca	7DD6-CaS-Ca-Ca; Ca; Tryptophan
12.50	Single	7DD6	Ca; Ca; Tryptophan	7DD6-CaS-Ca-Ca; Ca; Tryptophan
12.50	Single	7DD7	Ca	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
12.50	Single	7DD7	Ca	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
12.50	Single	7DD7	Ca; Ca; Tryptophan; Evocalcet	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
12.50	Single	7DD7	Ca; Ca; Tryptophan; Evocalcet	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
12.50	Single	7FIM	Tirzepatide	7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
12.50	Single	7LJC	PubChem 86764103	7LJC-D₁-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
12.50	Single	7V3Z	PubMed 104895	7V3Z-CB₁-PubMed 104895
12.50	Single	7W40	Bombesin	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
12.50	Single	7YK7	DC591053	7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
12.50	Single	8CU6	LJ-4517	8CU6-A_2A-LJ-4517
12.50	Single	8CU7	LJ-4517	8CU7-A_2A-LJ-4517-Na
12.50	Single	8IA2	C5a anaphylatoxin	8IA2-C5a₁-C5a anaphylatoxin-Go/&β;1/&γ;2
12.50	Single	8ID4	Linoleic acid	8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
12.50	Single	8X17	Namodenoson	8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
12.50	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
12.50	Single	9AYF	Ca	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
12.50	Consensus	adenosine_on	Orthosteric Ligand	a1_on a2_on
12.50	Consensus	alpha_off	Orthosteric Ligand	alpha1_off alpha2_off
12.50	Consensus	cb1_on_allo	Orthosteric Ligand	7WV9-CB₁-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
12.50	Consensus	gs_class-b	Orthosteric Ligand	gs_class-b1 gs_class-b2
12.50	Consensus	lipid_off	Orthosteric Ligand	cannabinoid_off leuko_off lpl_off paf_off prostanoid_off
12.50	Consensus	nucleotide_on	Orthosteric Ligand	adenosine_on
12.50	Consensus	p2y12_off	Orthosteric Ligand	4NTJ-P2Y₁₂-AZD1283 7PP1-P2Y₁₂-Selatogrel
12.50	Consensus	pth_on	Orthosteric Ligand	pth1_on pth2_on
12.00	Single	7KH0	Acyclovir triphosphate	7KH0-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
12.00	Single	7TRY	Urocortin	7TRY-CRF₂-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
12.00	Single	7V9M	Somatoliberin	7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
12.00	Single	8KH5	Lysophosphatidylserine	8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
12.00	Consensus	bk1_on	Orthosteric Ligand	7EIB-BK₁-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.00	Consensus	bombesin_on	Orthosteric Ligand	bb2_on bb1_on
12.00	Consensus	mc1_on	Orthosteric Ligand	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC₁-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
12.00	Consensus	vpac1_on	Orthosteric Ligand	8E3Y-VPAC₁-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2 6VN7-VPAC₁-PACAP-Gs/&β;1/&γ;2
11.76	Single	4NTJ	AZD1283	4NTJ-P2Y₁₂-AZD1283
11.76	Single	4PHU	Fasiglifam	4PHU-FFA1 (GPR40)-Fasiglifam
11.76	Single	5C1M	BU72	5C1M-μ-BU72
11.76	Single	5OM4	PubChem 135566609	5OM4-A_2A-PubChem 135566609-Na
11.76	Single	6D26	Fevipiprant	6D26-DP₂-Fevipiprant
11.76	Single	6DDE	Damgo	6DDE-μ-Damgo-Gi1/&β;1/&γ;2
11.76	Single	6GDG	NECA	6GDG-A_2A-NECA-Gs/&β;1/&γ;1
11.76	Single	6KPC	PubChem 145915889	6KPC-CB₂-PubChem 145915889
11.76	Single	6N4B	MDMB-Fubinaca	6N4B-CB₁-MDMB-Fubinaca-Gi1/&β;1/&γ;2
11.76	Single	6RZ4	Pranlukast	6RZ4-CysLT₁-Pranlukast-Na
11.76	Single	7CFN	INT-777	7CFN-GPBA-INT-777-Gs/&β;1/&γ;2
11.76	Single	7CKX	A77636	7CKX-D₁-A77636-Gs/&β;1/&γ;2
11.76	Single	7EO2	FTY720-P	7EO2-S1P₁-FTY720-P-Gi1/&β;1/&γ;2
11.76	Single	7EUO	fMLF	7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
11.76	Single	7LD3	Adenosine	7LD3-A₁-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
11.76	Single	7TD3	S1P	7TD3-S1P₁-S1P-Gi1/&β;1/&γ;2
11.76	Single	7VFX	fMLF	7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
11.76	Single	7VV0	PAMP-12	7VV0-MRGPRX2-PAMP-12
11.76	Single	7VV4	Cortistatin-14	7VV4-MRGPRX2-Cortistatin-14
11.76	Single	7WIG	L-054,264	7WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
11.76	Single	7YXA	ONO-5430608	7YXA-S1P₅-ONO-5430608
11.76	Single	8IZ4	Lysophosphatidylserine	8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
11.76	Single	8SZI	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
11.76	Consensus	a1_on_allo	Orthosteric Ligand	7LD3-A₁-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
11.76	Consensus	a2a_on	Orthosteric Ligand	6GDG-A_2A-NECA-Gs/&β;1/&γ;1
11.76	Consensus	cb2_on	Orthosteric Ligand	8GUS-CB₂-HU-308-Gi1/&β;1/&γ;2 8GUT-CB₂-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB₂-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB₂-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB₂-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB₂-WIN 55212-2-Gi1/&β;1/&γ;2
11.76	Consensus	gs_pth	Orthosteric Ligand	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
11.54	Single	7FIY	Tirzepatide	7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
11.54	Single	7KI0	Semaglutide	7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
11.54	Single	7RA3	GIP	7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
11.54	Single	7VAB	Non-Acylated Tirzepatide	7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
11.54	Consensus	ghrh_on	Orthosteric Ligand	7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
11.43	Consensus	class-b1_on	Orthosteric Ligand	glucagon_on calcitonin_on vip-pacap_on pth_on crf_on
11.11	Single	4RWA	DIPP-NH2	4RWA-δ-DIPP-NH2
11.11	Single	5TZR	-	5TZR-FFA1 (GPR40)-MK8666
11.11	Single	5XR8	AM841	5XR8-CB₁-AM841
11.11	Single	5XRA	AM11542	5XRA-CB₁-AM11542
11.11	Single	5ZBH	BMS-193885	5ZBH-Y₁-BMS-193885
11.11	Single	6GT3	Imaradenant	6GT3-A_2A-Imaradenant-Na
11.11	Single	6LMK	Glucagon	6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
11.11	Single	6Z4Q	SR142948A	6Z4Q-NTS₁-SR142948A
11.11	Single	7DTY	GIP	7DTY-GIP-GIP-Gs/&β;1/&γ;2
11.11	Single	7EIB	Des-Arg10-Kallidin	7EIB-BK₁-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.11	Single	7EW1	Siponimod	7EW1-S1P₅-Siponimod-Gi1/&β;1/&γ;2
11.11	Single	7F4F	Afamelanotide	7F4F-MC₁-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
11.11	Single	7FEE	PubMed 104895	7FEE-CB₁-PubMed 104895-ZCZ011
11.11	Single	7JV5	SKF81297	7JV5-D₁-SKF81297-Gs/&β;1/&γ;2
11.11	Single	7JVP	SKF83959	7JVP-D₁-SKF83959-Gs/&β;1/&γ;2
11.11	Single	7KNU	Calcitonin gene-related peptide-1	7KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
11.11	Single	7R0C	Acyclovir triphosphate	7R0C-V₂-Acyclovir triphosphate-Arrestin2
11.11	Single	7S8M	Cortistatin-14	7S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
11.11	Single	7T9M	CS-17 Antibody	7T9M-TSH-CS-17 Antibody
11.11	Single	7TD1	LPA	7TD1-LPA₁-LPA-Gi1/&β;1/&γ;2
11.11	Single	7VIG	CBP-307	7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2
11.11	Single	7VQX	PACAP27	7VQX-VPAC₁-PACAP27-Gs/&β;1/&γ;2
11.11	Single	7WV9	PubMed 104895	7WV9-CB₁-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
11.11	Single	8E0G	BU72	8E0G-μ-BU72
11.11	Single	8FU6	Glucagon derivative ZP3780	8FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
11.11	Single	8GUS	HU-308	8GUS-CB₂-HU-308-Gi1/&β;1/&γ;2
11.11	Single	8HS2	Fab046	8HS2-GPR20-Fab046
11.11	Consensus	a2_on	Orthosteric Ligand	a2a_on a2b_on
11.11	Consensus	a2b_on	Orthosteric Ligand	8HDP-A_2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A_2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A_2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A_2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
11.11	Consensus	gi_muscarinic	Orthosteric Ligand	7TRS-M₄-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M₄-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M₄-PubChem 9864275-Gi1/&β;1/&γ;2
11.11	Consensus	glp2_on	Orthosteric Ligand	7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
11.11	Consensus	go_class-b1	Orthosteric Ligand	go_crf
11.11	Consensus	go_crf	Orthosteric Ligand	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
11.11	Consensus	gs_adenosine	Orthosteric Ligand	8HDP-A_2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A_2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A_2A-NECA-Gs/&β;1/&γ;1 7XY7-A_2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A_2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
11.11	Consensus	gs_cgrp	Orthosteric Ligand	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
11.11	Consensus	gs_ffa	Orthosteric Ligand	8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP₄-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP₄-L902688-Gs/&β;1/&γ;2 8GDB-EP₄-PGE2-Gs/&β;1/&γ;2
11.11	Consensus	gs_nucleotide	Orthosteric Ligand	gs_adenosine
11.11	Consensus	npy_off	Orthosteric Ligand	npy2_off npy1_off
11.11	Consensus	relaxin_on	Orthosteric Ligand	rxfp4_on
11.11	Consensus	s1p5_on	Orthosteric Ligand	7EW1-S1P₅-Siponimod-Gi1/&β;1/&γ;2
11.11	Consensus	ste2_on	Orthosteric Ligand	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
10.81	Consensus	gs_class-b1	Orthosteric Ligand	gs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
10.71	Single	6LML	Glucagon	6LML-Glucagon-Glucagon
10.71	Single	6WZG	Secretin	6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
10.71	Single	8FLT	M-PTH(1-14)	8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
10.71	Consensus	calcitonin_on	Orthosteric Ligand	ct_on ctlike_on
10.71	Consensus	crf_on	Orthosteric Ligand	crf2_on crf1_on
10.71	Consensus	secretin_on	Orthosteric Ligand	6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
10.71	Consensus	vpac2_on	Orthosteric Ligand	7VQX-VPAC₁-PACAP27-Gs/&β;1/&γ;2
10.53	Single	4Z36	ONO-3080573	4Z36-LPA₁-ONO-3080573
10.53	Single	6KQI	PubMed 104895	6KQI-CB₁-PubMed 104895-ORG27569
10.53	Single	6MXT	Salmeterol	6MXT-β₂-Salmeterol
10.53	Single	6RZ7	ONO-2570366	6RZ7-CysLT₂-ONO-2570366
10.53	Single	6W2Y	PubChem 23727970	6W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
10.53	Single	6W2Y	PubChem 23727970	6W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
10.53	Single	7DH5	Mirabegron	7DH5-β₃-Mirabegron-Gs/&β;1/&γ;2
10.53	Single	7EVY	Siponimod	7EVY-S1P₁-Siponimod-Gi1/&β;1/&γ;2
10.53	Single	7EW2	Fingolimod	7EW2-S1P₃-Fingolimod-Gi1/&β;1/&γ;2
10.53	Single	7F55	Bremelanotide	7F55-MC₄-Bremelanotide-Gs/&β;1/&γ;2
10.53	Single	7W0L	PubChem 122701908	7W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
10.53	Single	7XW9	TRH	7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
10.53	Single	7XY7	NECA	7XY7-A_2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
10.53	Single	8I95	EP54	8I95-C3a_B-EP54-Go/&β;1/&γ;2
10.53	Single	8IA8	E7 peptide	8IA8-C3a_B-E7 peptide-Gi1/&β;1/&γ;2
10.53	Single	8J22	TUG-1375	8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
10.53	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
10.53	Single	8WRB	Lysophosphatidylserine	8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
10.53	Single	8WU1	KCA	8WU1-CB₁-KCA-Arrestin1
10.53	Consensus	cannabinoid_off	Orthosteric Ligand	cb1_off cb2_off
10.53	Consensus	cannabinoid_on	Orthosteric Ligand	cb1_on cb2_on
10.53	Consensus	cb1_off_allo	Orthosteric Ligand	6KQI-CB₁-PubMed 104895-ORG27569
10.53	Consensus	cb1_on	Orthosteric Ligand	8GHV-CB₁-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB₁-AM841-Gi1/&β;1/&γ;2 6N4B-CB₁-MDMB-Fubinaca-Gi1/&β;1/&γ;2
10.53	Consensus	gi_cannabinoid	Orthosteric Ligand	8GUS-CB₂-HU-308-Gi1/&β;1/&γ;2 8GUT-CB₂-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB₂-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB₂-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB₂-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB₂-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB₁-AM841-Gi1/&β;1/&γ;2 6N4B-CB₁-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB₁-PubChem 145964903-Gi1/&β;1/&γ;2
10.53	Consensus	go_5ht	Orthosteric Ligand	6G79-5-HT_1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT_5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT_5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT_5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
10.53	Consensus	gs_trh	Orthosteric Ligand	7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
10.53	Consensus	mop_on	Orthosteric Ligand	8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
10.53	Consensus	peptide_off	Orthosteric Ligand	opioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
10.53	Consensus	s1p_on	Orthosteric Ligand	s1p3_on s1p5_on s1p1_on s1p2_on
10.53	Consensus	trh_on	Orthosteric Ligand	7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
10.34	Single	7RBT	Tirzepatide	7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
10.34	Single	7TS0	Urocortin	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
10.34	Consensus	bb2_on	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
10.34	Consensus	gip_on	Orthosteric Ligand	7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
10.34	Consensus	gip_on_allo	Orthosteric Ligand	7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
10.34	Consensus	gq_bombesin	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
10.00	Single	5TUD	Ergotamine	5TUD-5-HT_2B-Ergotamine
10.00	Single	5TZY	MK8666; PubChem 127053597	5TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
10.00	Single	6DDF	Damgo	6DDF-μ-Damgo-Gi1/&β;1/&γ;2
10.00	Single	6LPB	PACAP	6LPB-PAC₁-PACAP-Gs/&β;1/&γ;1
10.00	Single	6O3C	Cholesterol	6O3C-SMO-SAG21k-Cholesterol
10.00	Single	6RZ9	ONO-2770372	6RZ9-CysLT₂-ONO-2770372
10.00	Single	6WPW	Glucagon derivative ZP3780	6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
10.00	Single	7EVZ	Cenerimod	7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2
10.00	Single	7EW0	Ozanimod	7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2
10.00	Single	7FIG	hCG	7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
10.00	Single	7UTZ	TR1402	7UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
10.00	Single	7XAV	Lanreotide	7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
10.00	Single	7XW5	TSH	7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
10.00	Single	7ZI0	Cholesterol	7ZI0-SMO-SAG-Cholesterol
10.00	Single	8GUT	LEI-102	8GUT-CB₂-LEI-102-Gi1/&β;1/&γ;2
10.00	Single	8ID8	TUG-891	8ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
10.00	Single	8TLM	Anti-murine CCR8 antibody	8TLM-CCR8-Anti-murine CCR8 antibody
10.00	Single	8WCB	Cyclohexylammonium ion	8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.00	Single	8WCC	Cyclohexylammonium ion	8WCC-TA1-Cyclohexylammonium ion
10.00	Single	8WRZ	8D0	8WRZ-CB₁-8D0-Arrestin1
10.00	Consensus	ccr8_off	Orthosteric Ligand	8TLM-CCR8-Anti-murine CCR8 antibody
10.00	Consensus	cyslt2_off	Orthosteric Ligand	6RZ6-CysLT₂-ONO-2570366 6RZ9-CysLT₂-ONO-2770372 6RZ8-CysLT₂-ONO-2080365
10.00	Consensus	cyslt_off	Orthosteric Ligand	cyslt2_off
10.00	Consensus	glp_on	Orthosteric Ligand	glp1_on glp2_on
10.00	Consensus	s1p1_on	Orthosteric Ligand	7TD3-S1P₁-S1P-Gi1/&β;1/&γ;2 7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P₁-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P₁-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P₁-PubChem 4077460-Gi1/&β;1/&γ;2
9.68	Single	7V35	Peptide-20	7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
9.68	Single	8JIP	MEDI0382	8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
9.68	Consensus	vip-pacap_on	Orthosteric Ligand	vpac1_on vpac2_on pca1_on
9.52	Single	3NY9	PubChem 913103	3NY9-β₂-PubChem 913103
9.52	Single	6PT3	DPI-287	6PT3-δ-DPI-287
9.52	Single	7S8L	Cortistatin-14	7S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.52	Single	7XY6	PubChem 11717831	7XY6-A_2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
9.52	Single	8INR	Alpha-MSH	8INR-MC₅-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
9.52	Single	8XZF	WN561	8XZF-Apelin-WN561-Gi1/&β;1/&γ;2
9.52	Consensus	class-d_off	Orthosteric Ligand	ste2_off
9.52	Consensus	fpr1-alx_on	Orthosteric Ligand	7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
9.52	Consensus	gi_lipid	Orthosteric Ligand	gi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
9.52	Consensus	lipid_on	Orthosteric Ligand	cannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
9.52	Consensus	ste2_off	Orthosteric Ligand	7QA8-STE2-Peptide
9.38	Single	8JIT	MEDI0382	8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
9.38	Consensus	pth2_on	Orthosteric Ligand	7F16-PTH2-TIP39-Gs/&β;1/&γ;2
9.09	Single	5L7D	Cholesterol	5L7D-SMO-Cholesterol
9.09	Single	5MZJ	Theophylline	5MZJ-A_2A-Theophylline-Na
9.09	Single	6RZ8	ONO-2080365	6RZ8-CysLT₂-ONO-2080365
9.09	Single	7F4I	SHU9119	7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
9.09	Single	7QA8	Peptide	7QA8-STE2-Peptide
9.09	Single	7QA8	Peptide	7QA8-STE2-Peptide
9.09	Single	7RTB	Peptide-19	7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
9.09	Single	7T9I	TSH	7T9I-TSH-TSH-Gs/&β;1/&γ;2
9.09	Single	7TD4	Siponimod	7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2
9.09	Single	7WKD	TRH	7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.09	Single	7XKE	Betahydroxyandrosterone	7XKE-ADGRG2-Betahydroxyandrosterone-chim(NtGi1-Gs)/&β;1/&γ;2
9.09	Single	8G59	TUG-891	8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
9.09	Single	8HSC	Fab046	8HSC-GPR20-Fab046-Gi1/&β;1/&γ;2
9.09	Single	8I2G	Glycoprotein hormones alpha chain	8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
9.09	Single	8IZB	Lysophosphatidylserine	8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
9.09	Single	8JIQ	Peptide-15	8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
9.09	Single	8JIU	SAR425899	8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
9.09	Single	8PWN	Theophylline	8PWN-A_2A-Theophylline
9.09	Consensus	class-d_off	Orthosteric Ligand	ste2_off
9.09	Consensus	ste2_off	Orthosteric Ligand	7QA8-STE2-Peptide
8.70	Single	6WHC	Glu16 analog of GCG	6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
8.70	Single	7CUM	Phospholipid	7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid
8.70	Single	7PIU	Setmelanotide	7PIU-MC₄-Setmelanotide-Gs/&β;1/&γ;2
8.70	Consensus	vasopressin-ot_on	Orthosteric Ligand	ot_on v2_on
8.57	Single	7F16	TIP39	7F16-PTH2-TIP39-Gs/&β;1/&γ;2
8.57	Consensus	glucagon_on	Orthosteric Ligand	gip_on glu_on secretin_on ghrh_on glp_on
8.33	Single	3RFM	Caffeine	3RFM-A_2A-Caffeine
8.33	Single	6OT0	25(S)-Epoxycholesterol	6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
8.33	Single	6W25	SHU9119	6W25-MC₄-SHU9119-Ca
8.33	Single	7T6T	fMLFII	7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
8.33	Single	7VDM	Substance P	7VDM-MRGPRX2-Substance P-Gi1/&β;1/&γ;2
8.33	Single	7XKD	Betahydroxyandrosterone	7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
8.33	Consensus	glu_on	Orthosteric Ligand	6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
8.33	Consensus	hca2_on_allo	Orthosteric Ligand	8J6P-HCA₂-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA₂-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
8.11	Consensus	gs_calcitonin	Orthosteric Ligand	gs_ct gs_cgrp
8.11	Consensus	gs_ct	Orthosteric Ligand	7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
8.00	Single	6NIY	Adrenomedullin	6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
8.00	Single	7DW9	Acyclovir triphosphate	7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
8.00	Single	7FIN	Peptide-20; GGL	7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
8.00	Single	7RYC	Oxytocin	7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.00	Consensus	pca1_on	Orthosteric Ligand	6M1I-PAC₁-PACAP-Gs/&β;1/&γ;2
8.00	Consensus	ste2_on	Orthosteric Ligand	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
8.00	Consensus	v2_on	Orthosteric Ligand	7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
7.69	Single	2J4Y	11-cis-Retinal	2J4Y-Rhodopsin-11-cis-Retinal
7.69	Single	3OE6	IT1t	3OE6-CXCR4-IT1t
7.69	Single	5WKT	Octyl Beta-D-Glucopyranoside	5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
7.69	Single	6FK9	PubChem 132473036	6FK9-Rhodopsin-PubChem 132473036
7.69	Single	6ME5	Agomelatine	6ME5-MT₁-Agomelatine
7.69	Single	6ME9	Ramelteon	6ME9-MT₂-Ramelteon
7.69	Single	6UUN	Adrenomedullin	6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
7.69	Single	7D77	Hydrocortisone	7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2
7.69	Single	7F23	Dopamine	7F23-D₁-Dopamine-GDP-Gs/&β;1/&γ;2
7.69	Single	7MT8	All-trans-retinal	7MT8-Rhodopsin-All-trans-retinal-GRK1
7.69	Single	7MT9	All-trans-retinal	7MT9-Rhodopsin-All-trans-retinal-GRK1
7.69	Single	7MTA	All-trans-retinal	7MTA-Rhodopsin-All-trans-retinal-GRK1
7.69	Single	7QBI	Alpha-factor mating pheromone	7QBI-STE2-Alpha-factor mating pheromone
7.69	Single	7S8O	(R)-Zinc-3573	7S8O-MRGPRX2-(R)-Zinc-3573-Gi1/&β;1/&γ;2
7.69	Single	7WBJ	PACAP27	7WBJ-VPAC₁-PACAP27-Gs/&β;1/&γ;2
7.69	Single	8EIT	Doconexent	8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
7.69	Single	8F76	-	8F76-OR51E2-Gs/&β;1/&γ;2
7.69	Single	8IOD	PG-901	8IOD-MC₅-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
7.69	Single	8J21	Butyric acid	8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
7.69	Single	8J24	Acetic acid	8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
7.69	Single	8J6Q	Beta-hydroxybutyrate	8J6Q-HCA₂-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
7.69	Single	8JGB	Conorfamide-Tx2	8JGB-MRGPRX1-Conorfamide-Tx2-Gi1/&β;1/&γ;2
7.69	Single	8WC6	2-Phenylethylamine	8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
7.69	Consensus	adgrg3_on	Orthosteric Ligand	7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
7.69	Consensus	crf2_on	Orthosteric Ligand	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
7.69	Consensus	ffa3_on	Orthosteric Ligand	8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
7.41	Single	6P9Y	PACAP	6P9Y-PAC₁-PACAP-Gs/&β;1/&γ;2
7.41	Single	7CZ5	Somatoliberin	7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
7.41	Single	7D3S	Secretin	7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
7.41	Single	7QBI	Alpha-factor mating pheromone	7QBI-STE2-Alpha-factor mating pheromone
7.41	Single	7XV3	Lysophosphatidylserine	7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
7.41	Consensus	class-d_on	Orthosteric Ligand	ste2_on
7.14	Single	3OE9	IT1t	3OE9-CXCR4-IT1t
7.14	Single	3V2W	PubChem 51892645	3V2W-S1P₁-PubChem 51892645
7.14	Single	5NX2	GLP-1 (Truncated)	5NX2-GLP-1-GLP-1 (Truncated)
7.14	Single	6FK6	PubChem 132473033	6FK6-Rhodopsin-PubChem 132473033
7.14	Single	6PGS	Geraniol	6PGS-Rhodopsin-Geraniol-Gt(CT)
7.14	Single	6PH7	Nerol	6PH7-Rhodopsin-Nerol-Gt(CT)
7.14	Single	6QNO	All-trans-retinal	6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
7.14	Single	6UVA	Adrenomedullin-2	6UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
7.14	Single	7AD3	Alpha-factor mating pheromone	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
7.14	Single	7D76	Beclomethasone	7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
7.14	Single	7QBC	Alpha-factor mating pheromone	7QBC-STE2-Alpha-factor mating pheromone
7.14	Single	7S8N	(R)-Zinc-3573	7S8N-MRGPRX2-(R)-Zinc-3573-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.14	Single	7XKF	Betahydroxyandrosterone	7XKF-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
7.14	Single	7XT9	Serotonin	7XT9-5-HT₄-Serotonin-Gs/&β;1/&γ;2
7.14	Single	7XTA	Serotonin	7XTA-5-HT₄-Serotonin-Gi1/&β;1/&γ;2
7.14	Single	8EF6	Morphine	8EF6-μ-Morphine-Gi1/&β;1/&γ;2
7.14	Single	8GGC	Epinephrine	8GGC-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
7.14	Single	8GGE	Epinephrine	8GGE-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
7.14	Single	8GH1	Epinephrine	8GH1-β₂-Epinephrine
7.14	Single	8H2G	Niacin	8H2G-HCA₂-Niacin-Gi1/&β;1/&γ;2
7.14	Single	8IHI	Acifran	8IHI-HCA₂-Acifran-Gi1/&β;1/&γ;2
7.14	Single	8IJA	Niacin	8IJA-HCA₂-Niacin-Gi1/&β;1/&γ;2
7.14	Single	8IY9	Niacin	8IY9-HCA₂-Niacin-Go/&β;1/&γ;2
7.14	Single	8J6Q	Compound 9n	8J6Q-HCA₂-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
7.14	Single	8JII	Compound 9n	8JII-HCA₂-Niacin-Compound 9n-Gi1/&β;1/&γ;2
7.14	Single	8JIL	Niacin	8JIL-HCA₂-Niacin-Gi1/&β;1/&γ;2
7.14	Single	8JLO	Ulotaront	8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
7.14	Single	8JSO	AMPH	8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
7.14	Single	8K5B	Niacin	8K5B-HCA₂-Niacin
7.14	Single	8W89	PEA	8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
7.14	Consensus	gi_class-d	Orthosteric Ligand	gi_ste
7.14	Consensus	gi_ste	Orthosteric Ligand	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
7.14	Consensus	go_adhesion	Orthosteric Ligand	7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
7.14	Consensus	go_class-b2	Orthosteric Ligand	go_adhesion
7.14	Consensus	hca2_on_allo	Other Ligand	8J6P-HCA₂-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA₂-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
7.14	Consensus	mt1_on	Orthosteric Ligand	7VGY-MT₁-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT₁-Ramelteon-Gi1/&β;1/&γ;2
6.90	Single	6PB1	Urocortin	6PB1-CRF₂-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
6.90	Single	6UUS	Adrenomedullin	6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
6.90	Single	7D68	GLP-2	7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
6.90	Single	7QBC	Alpha-factor mating pheromone	7QBC-STE2-Alpha-factor mating pheromone
6.90	Single	7TYW	Calcitonin-1	7TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
6.90	Consensus	crf1_on	Orthosteric Ligand	6P9X-CRF₁-Corticoliberin-Gs/&β;1/&γ;2
6.67	Single	1F88	11-cis-Retinal	1F88-Rhodopsin-11-cis-Retinal
6.67	Single	2X72	All-trans-retinal	2X72-Rhodopsin-All-trans-retinal-Gt(CT)
6.67	Single	3ODU	IT1t	3ODU-CXCR4-IT1t
6.67	Single	5OLH	Vipadenant	5OLH-A_2A-Vipadenant-Na
6.67	Single	5ZKQ	ABT-491	5ZKQ-PAF-ABT-491
6.67	Single	6D9H	Adenosine	6D9H-A₁-Adenosine-Gi2/&β;1/&γ;2
6.67	Single	6FKB	PubChem 132473038	6FKB-Rhodopsin-PubChem 132473038
6.67	Single	6ME2	Ramelteon	6ME2-MT₁-Ramelteon
6.67	Single	6NWE	Octyl Beta-D-Glucopyranoside	6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
6.67	Single	6OYA	All-trans-retinal	6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
6.67	Single	6PB0	Urocortin	6PB0-CRF₁-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
6.67	Single	7F1O	Dopamine	7F1O-D₁-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
6.67	Single	7LD4	Adenosine	7LD4-A₁-Adenosine-Gi2/&β;1/&γ;2
6.67	Single	7T6S	PubChem 24776341	7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
6.67	Single	7TYF	Amylin	7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
6.67	Single	7TYL	Amylin	7TYL-CT-Amylin-Gs/&β;1/&γ;2
6.67	Single	7TYN	Calcitonin-1	7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
6.67	Single	7TYX	Amylin	7TYX-CT (AMY2)-Amylin-Gs/&β;1/&γ;2; RAMP2
6.67	Single	7VIH	CBP-307	7VIH-S1P₁-CBP-307-Gi1/&β;1/&γ;2
6.67	Single	7XT8	Serotonin	7XT8-5-HT₄-Serotonin-Gs/&β;1/&γ;2
6.67	Single	8DWH	Compound-16	8DWH-MRGPRX1-Compound-16-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.67	Single	8GGF	Epinephrine	8GGF-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
6.67	Single	8HDP	Adenosine	8HDP-A_2B-Adenosine-Gs/&β;1/&γ;2
6.67	Single	8IJB	Acipimox	8IJB-HCA₂-Acipimox-Gi1/&β;1/&γ;2
6.67	Single	8J20	Valeric acid	8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
6.67	Single	8J6L	Niacin	8J6L-HCA₂-Niacin-Gi1/&β;1/&γ;2
6.67	Single	8J6P	Compound 9n	8J6P-HCA₂-Niacin-Compound 9n-Gi1/&β;1/&γ;2
6.67	Single	8JHY	Compound 9n	8JHY-HCA₂-Compound 9n-Gi1/&β;1/&γ;2
6.67	Single	8U8F	PML	8U8F-GPR3-PML-Gs/&β;1/&γ;2
6.67	Single	8UO1	Epinephrine	8UO1-β₂-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
6.67	Single	8UO3	Epinephrine	8UO3-β₂-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
6.67	Single	8WC4	ZH8651	8WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
6.67	Single	8WCA	2-Phenylethylamine	8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
6.67	Consensus	a1_on	Orthosteric Ligand	7LD4-A₁-Adenosine-Gi2/&β;1/&γ;2
6.67	Consensus	ffa3_on_allo	Orthosteric Ligand	8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
6.67	Consensus	gi_nucleotide	Orthosteric Ligand	7LD4-A₁-Adenosine-Gi2/&β;1/&γ;2
6.67	Consensus	gs_crf	Orthosteric Ligand	6P9X-CRF₁-Corticoliberin-Gs/&β;1/&γ;2
6.67	Consensus	gt_class-a	Orthosteric Ligand	gt_opsin
6.67	Consensus	gt_opsin	Orthosteric Ligand	gt_sensory
6.67	Consensus	gt_sensory	Orthosteric Ligand	6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
6.67	Consensus	melatonin_on	Orthosteric Ligand	mt1_on mt2_on
6.67	Consensus	mglu_on	Other Ligand	mglu2_on mglu4_on
6.67	Consensus	smo_on_allo	Other Ligand	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
6.45	Single	7TYH	Calcitonin-1	7TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
6.25	Single	2YDO	Adenosine	2YDO-A_2A-Adenosine
6.25	Single	3UZC	PubChem 135566609	3UZC-A_2A-PubChem 135566609
6.25	Single	3V2Y	PubChem 51892645	3V2Y-S1P₁-PubChem 51892645
6.25	Single	4DKL	Beta-funaltrexamine	4DKL-μ-Beta-funaltrexamine
6.25	Single	4N6H	Naltrindole	4N6H-δ-Naltrindole-Na
6.25	Single	5TE3	Octyl Beta-D-Glucopyranoside	5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
6.25	Single	6FKA	PubChem 132473037	6FKA-Rhodopsin-PubChem 132473037
6.25	Single	6ME3	2-Phenylmelatonin	6ME3-MT₁-2-Phenylmelatonin
6.25	Single	6ME4	2-Iodomelatonin	6ME4-MT₁-2-Iodomelatonin
6.25	Single	6PEL	Citronellol	6PEL-Rhodopsin-Citronellol-Gt(CT)
6.25	Single	7CKW	Fenoldopam	7CKW-D₁-Fenoldopam-Gs/&β;1/&γ;2
6.25	Single	7CKZ	Dopamine	7CKZ-D₁-Dopamine-Mevidalen-Gs/&β;1/&γ;2
6.25	Single	7F0T	Dopamine	7F0T-D₁-Dopamine-Gs/&β;1/&γ;2
6.25	Single	7F1Z	Dopamine	7F1Z-D₁-Dopamine-GDP-Gs/&β;1/&γ;2
6.25	Single	7F61	PF-03654746	7F61-H₃-PF-03654746-Cholesterol
6.25	Single	7JOZ	VFP	7JOZ-D₁-VFP-Gs/&β;1/&γ;2
6.25	Single	7S8P	MS47134	7S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.25	Single	7TZF	Amylin	7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
6.25	Single	7VUG	JNJ-63533054	7VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
6.25	Single	7VVO	PTH	7VVO-PTH1-PTH-Gs/&β;1/&γ;2
6.25	Single	7WC9	PubChem 162421364	7WC9-5-HT_2A-PubChem 162421364
6.25	Single	7YK6	PubChem 138319674	7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
6.25	Single	8DWG	ML382	8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.25	Single	8GCM	L902688	8GCM-EP₄-L902688-Gi1/&β;1/&γ;2
6.25	Single	8GDZ	Epinephrine	8GDZ-β₂-Epinephrine-Gs/&β;1/&γ;2
6.25	Single	8GG8	Epinephrine	8GG8-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
6.25	Single	8GGT	Epinephrine	8GGT-β₂-Epinephrine
6.25	Single	8GUQ	Olorinab	8GUQ-CB₂-Olorinab-Gi1/&β;1/&γ;2
6.25	Single	8J6P	Niacin	8J6P-HCA₂-Niacin-Compound 9n-Gi1/&β;1/&γ;2
6.25	Single	8JER	Acipimox	8JER-HCA₂-Acipimox-Go/&β;1/&γ;2
6.25	Single	8JHN	MMF	8JHN-HCA₂-MMF-Go/&β;1/&γ;2
6.25	Single	8JIM	MMF	8JIM-HCA₂-MMF-Gi1/&β;1/&γ;2
6.25	Single	8JLK	Ulotaront	8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
6.25	Single	8JLQ	Fenoldopam	8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
6.25	Single	8K2W	AMG487	8K2W-CXCR3-AMG487
6.25	Single	8K5C	Acipimox	8K5C-HCA₂-Acipimox
6.25	Single	8T3V	DHA	8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.25	Single	8UHB	RO5256390	8UHB-TA1-RO5256390-Gs/&β;1/&γ;2
6.25	Single	8UO2	Epinephrine	8UO2-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
6.25	Single	8W88	SEP-363856	8W88-TA1-SEP-363856-Gs/&β;1/&γ;2
6.25	Single	8X7A	Treprostinil	8X7A-I2-Treprostinil-Gs/&β;1/&γ;2
6.25	Consensus	d1_on_allo	Orthosteric Ligand	7LJC-D₁-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D₁-Dopamine-Mevidalen-Gs/&β;1/&γ;2
6.25	Consensus	dop_off_allo	Orthosteric Ligand	4N6H-δ-Naltrindole-Na
6.25	Consensus	gi_melatonin	Orthosteric Ligand	7VGY-MT₁-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT₁-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT₂-Ramelteon-Gi1/&β;1/&γ;1
6.25	Consensus	gs_tar	Orthosteric Ligand	8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
6.25	Consensus	h3_on_allo	Orthosteric Ligand	7F61-H₃-PF-03654746-Cholesterol
6.25	Consensus	hca_on	Orthosteric Ligand	hca2_on hca3_on
6.25	Consensus	hcar_on	Orthosteric Ligand	hca_on
6.25	Consensus	s1p1_off	Orthosteric Ligand	3V2Y-S1P₁-PubChem 51892645
6.25	Consensus	s1p_off	Orthosteric Ligand	s1p1_off
6.25	Consensus	sensory_off	Orthosteric Ligand	opsin_off
6.06	Single	7TYY	Calcitonin-1	7TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
6.06	Single	9AUC	Calcitonin gene-related peptide-1	9AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
5.88	Single	4EJ4	Naltrindole	4EJ4-δ-Naltrindole
5.88	Single	4J4Q	Octyl Beta-D-Glucopyranoside	4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
5.88	Single	4X1H	Nonyl Beta-D-Glucopyranoside	4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
5.88	Single	5OLZ	PubChem 135566609	5OLZ-A_2A-PubChem 135566609-Na
5.88	Single	5OM1	PubChem 135566609	5OM1-A_2A-PubChem 135566609-Na
5.88	Single	5UIG	J3.651.884G	5UIG-A_2A-J3.651.884G
5.88	Single	5ZKP	Foropafant (SR27417)	5ZKP-PAF-Foropafant (SR27417)
5.88	Single	6IIV	Daltroban	6IIV-TP-Daltroban
5.88	Single	6KPF	PubChem 145915889	6KPF-CB₂-PubChem 145915889-Gi1/&β;1/&γ;2
5.88	Single	6PS1	Timolol	6PS1-β₂-Timolol
5.88	Single	6PS8	2-Phenylmelatonin	6PS8-MT₁-2-Phenylmelatonin
5.88	Single	7DB6	Ramelteon	7DB6-MT₁-Ramelteon-Gi1/&β;1/&γ;2
5.88	Single	7E9G	JNJ-40411813	7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
5.88	Single	7JVQ	Apomorphine	7JVQ-D₁-Apomorphine-Gs/&β;1/&γ;2
5.88	Single	7PP1	Selatogrel	7PP1-P2Y₁₂-Selatogrel
5.88	Single	7T6V	fMLFII	7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
5.88	Single	7VGZ	Remalteon	7VGZ-MT₁-Remalteon-Gi1/&β;1/&γ;2
5.88	Single	7VIE	S1P	7VIE-S1P₁-S1P-Gi1/&β;1/&γ;2
5.88	Single	7VIF	(S)-FTY720-P	7VIF-S1P₁-(S)-FTY720-P-Gi1/&β;1/&γ;2
5.88	Single	7X2C	Fenoldopam	7X2C-D₁-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
5.88	Single	7YAC	Paltusotine	7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
5.88	Single	8EFQ	Damgo	8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
5.88	Single	8EJC	TAK-875	8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
5.88	Single	8EJK	TAK-875	8EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
5.88	Single	8GEB	Epinephrine	8GEB-β₂-Epinephrine-Gs/&β;1/&γ;2
5.88	Single	8GEH	Epinephrine	8GEH-β₂-Epinephrine-Gs/&β;1/&γ;2
5.88	Single	8GGB	Epinephrine	8GGB-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
5.88	Single	8I7V	Acipimox	8I7V-HCA₂-Acipimox-Gi1/&β;1/&γ;2
5.88	Single	8J18	(3R)-3-hydroxydodecanoic acid	8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
5.88	Single	8JGG	BAM8-22	8JGG-MRGPRX1-BAM8-22-Gi1/&β;1/&γ;2
5.88	Single	8JII	Niacin	8JII-HCA₂-Niacin-Compound 9n-Gi1/&β;1/&γ;2
5.88	Single	8JLZ	ST1936	8JLZ-5-HT₆-ST1936-Gs/&β;1/&γ;2
5.88	Single	8JT8	(R)-IHCH-7179	8JT8-5-HT_2A-(R)-IHCH-7179
5.88	Single	8UNM	Epinephrine	8UNM-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
5.88	Single	8W87	METH	8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
5.88	Single	8W8A	RO5256390	8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
5.88	Single	8XJL	PGF2-alpha	8XJL-FP-alpha-PGF2-alpha-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
5.88	Consensus	5ht1a_on	Orthosteric Ligand	8JSP-5-HT_1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT_1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT_1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT_1A-Serotonin-Gi1/&β;1/&γ;2
5.88	Consensus	5ht6_on	Orthosteric Ligand	7XTB-5-HT₆-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT₆-ST1936-Gs/&β;1/&γ;2
5.88	Consensus	d5_on	Orthosteric Ligand	8IRV-D₅-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
5.88	Consensus	dop_off	Orthosteric Ligand	4EJ4-δ-Naltrindole
5.88	Consensus	ffa1_on	Orthosteric Ligand	8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.88	Consensus	gi_hca	Orthosteric Ligand	8H2G-HCA₂-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA₃-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA₂-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA₂-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA₂-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA₂-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA₂-MMF-Gi1/&β;1/&γ;2 8IJB-HCA₂-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA₂-MK6892-Gi1/&β;1/&γ;2
5.88	Consensus	gi_hcar	Orthosteric Ligand	gi_hca
5.88	Consensus	hca2_on	Orthosteric Ligand	8H2G-HCA₂-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA₂-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA₂-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA₂-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA₂-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA₂-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA₂-MMF-Gi1/&β;1/&γ;2 8IJB-HCA₂-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA₂-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA₂-GSK256073-Gi1/&β;1/&γ;2
5.88	Consensus	hca3_on	Orthosteric Ligand	8IHJ-HCA₃-Acifran-Gi1/&β;1/&γ;2
5.88	Consensus	paf_off	Orthosteric Ligand	5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
5.88	Consensus	prostanoid_off	Orthosteric Ligand	ep_off tp_off dp_off
5.88	Consensus	tar_on	Orthosteric Ligand	ta1_on
5.88	Consensus	tp_off	Orthosteric Ligand	6IIV-TP-Daltroban 6IIU-TP-Ramatroban
5.71	Single	8F2A	Pramlintide analogue san385	8F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
5.56	Single	5YHL	PubChem 135121352	5YHL-EP₄-PubChem 135121352
5.56	Single	5YWY	ONO-AE3-208	5YWY-EP₄-ONO-AE3-208
5.56	Single	5ZK3	Quinuclidinyl benzilate hydrobromide	5ZK3-M₂-Quinuclidinyl benzilate hydrobromide
5.56	Single	6LUQ	Haloperidol	6LUQ-D₂-Haloperidol
5.56	Single	6M9T	Misoprostol-FA	6M9T-EP₃-Misoprostol-FA
5.56	Single	6ME7	2-Phenylmelatonin	6ME7-MT₂-2-Phenylmelatonin
5.56	Single	6ME8	2-Phenylmelatonin	6ME8-MT₂-2-Phenylmelatonin
5.56	Single	6W2X	PubChem 23727970	6W2X-GABA_B1, GABA_B2-PubChem 5311042-PubChem 23727970
5.56	Single	7BZ2	Arformoterol	7BZ2-β₂-Arformoterol-Gs/&β;1/&γ;2
5.56	Single	7C4S	S1P	7C4S-S1P₃-S1P
5.56	Single	7EW3	S1P	7EW3-S1P₃-S1P-Gi1/&β;1/&γ;2
5.56	Single	7XKA	Epinephrine	7XKA-β₂-Epinephrine
5.56	Single	8DZQ	momSalB	8DZQ-κ-momSalB-Go/&β;1/&γ;2
5.56	Single	8GD9	Rivenprost	8GD9-EP₄-Rivenprost-Gs/&β;1/&γ;2
5.56	Single	8GDA	L902688	8GDA-EP₄-L902688-Gs/&β;1/&γ;2
5.56	Single	8GDC	PGE2	8GDC-EP₃-PGE2-Gi1/&β;1/&γ;2
5.56	Single	8IHJ	Acifran	8IHJ-HCA₃-Acifran-Gi1/&β;1/&γ;2
5.56	Single	8J19	PubChem 127045422	8J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
5.56	Single	8J6J	GSK256073	8J6J-HCA₂-GSK256073-Gi1/&β;1/&γ;2
5.56	Single	8K8J	Fenofibrate	8K8J-CB₁-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
5.56	Single	8KFX	LMD-009	8KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
5.56	Single	8UNY	Epinephrine	8UNY-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
5.56	Consensus	adrenergic_off	Orthosteric Ligand	beta_off alpha_off
5.56	Consensus	beta3_on	Orthosteric Ligand	7DH5-β₃-Mirabegron-Gs/&β;1/&γ;2 7XJH-β₃-Isoproterenol-Gs/&β;1/&γ;2
5.56	Consensus	d1_on	Orthosteric Ligand	7F0T-D₁-Dopamine-Gs/&β;1/&γ;2 7CKY-D₁-PW0464-Gs/&β;1/&γ;2 8IRR-D₁-Rotigotine-Gs/&β;1/&γ;2 7JV5-D₁-SKF81297-Gs/&β;1/&γ;2 7JVP-D₁-SKF83959-Gs/&β;1/&γ;2 7X2D-D₁-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D₁-VFP-Gs/&β;1/&γ;2 7CKX-D₁-A77636-Gs/&β;1/&γ;2 7JVQ-D₁-Apomorphine-Gs/&β;1/&γ;2
5.56	Consensus	d2_on	Orthosteric Ligand	7JVR-D₂-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D₂-Rotigotine-Gi1/&β;1/&γ;2
5.56	Consensus	ep3_on	Orthosteric Ligand	8GDC-EP₃-PGE2-Gi1/&β;1/&γ;2
5.56	Consensus	ep4_off	Orthosteric Ligand	5YWY-EP₄-ONO-AE3-208 5YHL-EP₄-PubChem 135121352
5.56	Consensus	ep_off	Orthosteric Ligand	ep4_off
5.56	Consensus	go_opioid	Orthosteric Ligand	8DZQ-κ-momSalB-Go/&β;1/&γ;2
5.56	Consensus	gs_adrenergic	Orthosteric Ligand	3SN6-β₂-BI167107-Gs/&β;1/&γ;2 7DHR-β₂-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β₂-Salbutamol-Gs/&β;1/&γ;2 7XJH-β₃-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β₃-Mirabegron-Gs/&β;1/&γ;2 7XJI-β₃-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β₁-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β₁-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β₂-Arformoterol-Gs/&β;1/&γ;2
5.56	Consensus	rxfp4_on	Orthosteric Ligand	7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
5.56	Consensus	ta1_on	Orthosteric Ligand	8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
5.41	Single	7TYO	Calcitonin	7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
5.26	Single	2YDV	NECA	2YDV-A_2A-NECA
5.26	Single	3P0G	BI167107	3P0G-β₂-BI167107
5.26	Single	3SN6	BI167107	3SN6-β₂-BI167107-Gs/&β;1/&γ;2
5.26	Single	3UON	Quinuclidinyl benzilate hydrobromide	3UON-M₂-Quinuclidinyl benzilate hydrobromide
5.26	Single	4LDL	Hydroxybenzylisoproterenol	4LDL-β₂-Hydroxybenzylisoproterenol
5.26	Single	4UHR	CGS21680	4UHR-A_2A-CGS21680
5.26	Single	5A8E	7-Methylcyanopindolol	5A8E-β₁-7-Methylcyanopindolol-Na
5.26	Single	5G53	NECA	5G53-A_2A-NECA-Gs
5.26	Single	5ZHP	PubChem 134828589	5ZHP-M₃-PubChem 134828589
5.26	Single	6J21	Aprepitant	6J21-NK₁-Aprepitant
5.26	Single	6NI3	BI167107	6NI3-β₂-BI167107-Gs/&β;1/&γ;2
5.26	Single	6O3C	Cholesterol	6O3C-SMO-SAG21k-Cholesterol
5.26	Single	6W2X	PubChem 23727970	6W2X-GABA_B1, GABA_B2-PubChem 5311042-PubChem 23727970
5.26	Single	7B6W	Cyclazosin	7B6W-α_1b-Cyclazosin
5.26	Single	7CKY	PW0464	7CKY-D₁-PW0464-Gs/&β;1/&γ;2
5.26	Single	7E2Z	Aripiprazole	7E2Z-5-HT_1A-Aripiprazole-Gi1/&β;1/&γ;2
5.26	Single	7EW7	PubChem 4077460	7EW7-S1P₁-PubChem 4077460-Gi1/&β;1/&γ;2
5.26	Single	7M8W	15r-Methyl-Prostaglandin D2	7M8W-DP₂-15r-Methyl-Prostaglandin D2-Na
5.26	Single	7T2H	Lofentanil	7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
5.26	Single	7TUY	GSK682753A	7TUY-GPR183-GSK682753A
5.26	Single	7VGY	2-Iodomelatonin	7VGY-MT₁-2-Iodomelatonin-Gi1/&β;1/&γ;2
5.26	Single	7W41	PD176252	7W41-BB₂-PD176252
5.26	Single	8DCS	Cyanopindolol	8DCS-β₁-Cyanopindolol-Gs/&β;1/&γ;2
5.26	Single	8DZP	momSalB	8DZP-κ-momSalB-Gi1/&β;1/&γ;2
5.26	Single	8F2B	Pramlintide analogue san45	8F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
5.26	Single	8G05	6-OAU	8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
5.26	Single	8HDO	BAY 60-6583	8HDO-A_2B-BAY 60-6583-Gs/&β;1/&γ;2
5.26	Single	8IHB	GSK256073	8IHB-HCA₂-GSK256073-Gi1/&β;1/&γ;2
5.26	Single	8IHH	LUF6283	8IHH-HCA₂-LUF6283-Gi1/&β;1/&γ;2
5.26	Single	8IYW	GSK256073	8IYW-HCA₂-GSK256073-Go/&β;1/&γ;2
5.26	Single	8JLP	Ralmitaront	8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
5.26	Single	8JXV	Clozapine	8JXV-H₄-Clozapine-Gi1/&β;1/&γ;2
5.26	Single	8JXW	VUF6884	8JXW-H₄-VUF6884-Gi1/&β;1/&γ;2
5.26	Single	8X79	MRE-269	8X79-I2-MRE-269-Gs/&β;1/&γ;2
5.26	Single	8XJM	Latanoprost	8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
5.26	Consensus	alpha1b_off	Orthosteric Ligand	7B6W-α_1b-Cyclazosin
5.26	Consensus	bb2_off	Orthosteric Ligand	7W41-BB₂-PD176252
5.26	Consensus	bombesin_off	Orthosteric Ligand	bb2_off
5.26	Consensus	gi_dopamine	Orthosteric Ligand	8IRT-D₃-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D₂-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D₂-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D₃-PD128907-Gi1/&β;1/&γ;2 7CMU-D₃-Pramipexole-Gi1/&β;1/&γ;2
5.26	Consensus	gs_dopamine	Orthosteric Ligand	7F0T-D₁-Dopamine-Gs/&β;1/&γ;2 7CKX-D₁-A77636-Gs/&β;1/&γ;2 7JVQ-D₁-Apomorphine-Gs/&β;1/&γ;2 7CKY-D₁-PW0464-Gs/&β;1/&γ;2 8IRV-D₅-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D₁-SKF81297-Gs/&β;1/&γ;2 7JVP-D₁-SKF83959-Gs/&β;1/&γ;2 7X2D-D₁-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D₁-VFP-Gs/&β;1/&γ;2
5.26	Consensus	mglu2_on	Other Ligand	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
5.26	Consensus	s1p2_on	Orthosteric Ligand	7T6B-S1P₂-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
5.26	Consensus	s1p3_on	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/&β;1/&γ;2 7EW4-S1P₃-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P₃-Fingolimod-Gi1/&β;1/&γ;2
5.00	Single	2YCX	Cyanopindolol	2YCX-β₁-Cyanopindolol
5.00	Single	4N4W	SANT-1	4N4W-SMO-SANT-1
5.00	Single	6A93	Risperidone	6A93-5-HT_2A-Risperidone
5.00	Single	6AK3	Dinoprostone IPGE2	6AK3-EP₃-Dinoprostone IPGE2
5.00	Single	6CM4	Risperidone	6CM4-D₂-Risperidone
5.00	Single	6DRY	Methylergonovine	6DRY-5-HT_2B-Methylergonovine
5.00	Single	6IIU	Ramatroban	6IIU-TP-Ramatroban
5.00	Single	6ME6	2-Phenylmelatonin	6ME6-MT₂-2-Phenylmelatonin
5.00	Single	6VMS	Bromoergocryptine	6VMS-D₂-Bromoergocryptine-Gi1/&β;1/&γ;2
5.00	Single	6XBL	Cholesterol	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
5.00	Single	6XOX	Orforglipron	6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
5.00	Single	7D7M	Dinoprostone	7D7M-EP₄-Dinoprostone-Gs/&β;1/&γ;1
5.00	Single	7EO4	BAF312	7EO4-S1P₁-BAF312-Gi1/&β;1/&γ;2
5.00	Single	7EXD	Lasmiditan	7EXD-5-HT_1F-Lasmiditan-Gi1/&β;1/&γ;2
5.00	Single	7L1V	PubChem 155491009	7L1V-OX₂-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.00	Single	7T6B	S1P	7T6B-S1P₂-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
5.00	Single	7WCM	MBX-2982	7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
5.00	Single	7WCN	AR231453	7WCN-GPR119-AR231453-Gs/&β;1/&γ;2
5.00	Single	7XZ5	Lysophosphatidylcholine	7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
5.00	Single	7YIT	Nalfurafine	7YIT-κ-Nalfurafine
5.00	Single	8F0J	Pramlintide analogue san45	8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2
5.00	Single	8GCP	PGE2	8GCP-EP₄-PGE2-Gi1/&β;1/&γ;2
5.00	Single	8IJD	MK6892	8IJD-HCA₂-MK6892-Gi1/&β;1/&γ;2
5.00	Single	8IRS	Rotigotine	8IRS-D₂-Rotigotine-Gi1/&β;1/&γ;2
5.00	Single	8IRV	Rotigotine	8IRV-D₅-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
5.00	Single	8JJ8	Formoterol	8JJ8-β₂-Formoterol
5.00	Single	8JJL	Olodaterol	8JJL-β₂-Olodaterol
5.00	Single	8JWY	PubChem 168451710	8JWY-A_2A-PubChem 168451710
5.00	Single	8JZ7	MK6892	8JZ7-HCA₂-MK6892-Gi1/&β;1/&γ;2
5.00	Consensus	5ht1f_on	Orthosteric Ligand	7EXD-5-HT_1F-Lasmiditan-Gi1/&β;1/&γ;2
5.00	Consensus	adgrg_on	Orthosteric Ligand	adgrg2_on adgrg3_on
5.00	Consensus	class-b2_on	Orthosteric Ligand	adgrg_on
5.00	Consensus	d2_off	Orthosteric Ligand	6CM4-D₂-Risperidone 6LUQ-D₂-Haloperidol 7DFP-D₂-Spiperone
5.00	Consensus	ep_on	Orthosteric Ligand	ep4_on ep2_on ep3_on
5.00	Consensus	gi_class-f	Other Ligand	gi_frizzled
5.00	Consensus	gi_frizzled	Other Ligand	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
5.00	Consensus	gi_prostanoid	Orthosteric Ligand	8GCP-EP₄-PGE2-Gi1/&β;1/&γ;2 8GDC-EP₃-PGE2-Gi1/&β;1/&γ;2 8GCM-EP₄-L902688-Gi1/&β;1/&γ;2
5.00	Consensus	gpr119_on	Orthosteric Ligand	7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
5.00	Consensus	gs_amine	Orthosteric Ligand	gs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
5.00	Consensus	leuko_off	Orthosteric Ligand	blt_off cyslt_off
5.00	Consensus	opioid_off	Orthosteric Ligand	kop_off mop_off nop_off dop_off
5.00	Consensus	prostanoid_on	Orthosteric Ligand	ep_on fpa_on
4.76	Single	2YCZ	Iodocyanopindolol	2YCZ-β₁-Iodocyanopindolol
4.76	Single	4BVN	Cyanopindolol	4BVN-β₁-Cyanopindolol-Na
4.76	Single	6IBL	Arformoterol	6IBL-β₁-Arformoterol
4.76	Single	7CX4	Evatanepag	7CX4-EP₂-Evatanepag-Gs/&β;1/&γ;2
4.76	Single	7JVR	Bromoergocryptine	7JVR-D₂-Bromoergocryptine-Gi1/&β;1/&γ;2
4.76	Single	7MTS	ADX55164	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
4.76	Single	7QVM	Oxytocin	7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
4.76	Single	7X2D	Tavapadon	7X2D-D₁-Tavapadon-Gs/&β;1/&γ;2
4.76	Single	7XK2	MK6892	7XK2-HCA₂-MK6892-Gi1/&β;1/&γ;2
4.76	Single	8E9X	2-Deoxycytidine	8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
4.76	Single	8FX5	Xanomeline	8FX5-M₄-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
4.76	Single	8GAG	YVF	8GAG-CB₁-YVF-Gi1/&β;1/&γ;2
4.76	Single	8IQ6	Latanoprost	8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76	Single	8IUL	Latanoprost	8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76	Single	8K2X	CXCL10	8K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
4.76	Single	8T3O	TUG-891	8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.76	Single	8XJO	U46619	8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76	Consensus	adgrg2_on	Orthosteric Ligand	7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
4.76	Consensus	beta1_off_allo	Orthosteric Ligand	4BVN-β₁-Cyanopindolol-Na
4.76	Consensus	ep2_on	Orthosteric Ligand	7CX4-EP₂-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP₂-PGE2-Gs/&β;1/&γ;2 7CX3-EP₂-Taprenepag-Gs/&β;1/&γ;2
4.76	Consensus	ep4_on	Orthosteric Ligand	7D7M-EP₄-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP₄-PGE2-Gi1/&β;1/&γ;2 8GD9-EP₄-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP₄-L902688-Gs/&β;1/&γ;2
4.76	Consensus	ffa4_on_allo	Orthosteric Ligand	8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.76	Consensus	fpa_on	Orthosteric Ligand	8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76	Consensus	gs_lipid	Orthosteric Ligand	gs_ffa gs_prostanoid
4.76	Consensus	gs_prostanoid	Orthosteric Ligand	8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP₂-PGE2-Gs/&β;1/&γ;2 7CX3-EP₂-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP₄-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP₂-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76	Consensus	ot_on	Orthosteric Ligand	7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
4.55	Single	5EE7	MK0893	5EE7-Glucagon-MK0893
4.55	Single	5ZTY	AM10257	5ZTY-CB₂-AM10257
4.55	Single	6XBJ	Cholesterol	6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
4.55	Single	7MTR	ADX55164	7MTR-mGlu2; mGlu2-Glutamate-ADX55164
4.55	Single	8F7R	Endomorphin	8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
4.55	Single	8IQ4	Carboprost	8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.55	Single	8IUM	Tafluprost acid	8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.55	Single	8IYH	MK6892	8IYH-HCA₂-MK6892-Go/&β;1/&γ;2
4.55	Single	8JLR	A77636	8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Consensus	cb2_off	Orthosteric Ligand	5ZTY-CB₂-AM10257
4.55	Consensus	go_vasopressin	Orthosteric Ligand	7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
4.55	Consensus	gs_adgr	Orthosteric Ligand	7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Consensus	gs_class-b2	Orthosteric Ligand	gs_adgr
4.35	Single	6X19	CHU-128	6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
4.35	Single	7CX3	Taprenepag	7CX3-EP₂-Taprenepag-Gs/&β;1/&γ;2
4.35	Single	8J6R	MK6892	8J6R-HCA₂-MK6892-Gi1/&β;1/&γ;2
4.17	Single	6HLO	Aprepitant	6HLO-NK₁-Aprepitant
4.17	Single	7CUM	Phospholipid	7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid
4.17	Single	7DDZ	JNJ-31020028	7DDZ-Y₂-JNJ-31020028
4.17	Single	7E14	Orforglipron	7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
4.17	Consensus	npy2_off	Orthosteric Ligand	7DDZ-Y₂-JNJ-31020028
4.00	Consensus	mc5_on	Orthosteric Ligand	8INR-MC₅-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC₅-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
3.85	Single	6WIV	PubChem 52923113; PubChem 52924645	6WIV-GABA_B1, GABA_B2-PubChem 52923113; PubChem 52924645
3.85	Single	7AD3	Alpha-factor mating pheromone	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
3.85	Single	7WUI	IP15	7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
3.85	Single	8IHF	MK6892	8IHF-HCA₂-MK6892-Gi1/&β;1/&γ;2
3.85	Single	8J6I	MK6892	8J6I-HCA₂-MK6892-Gi1/&β;1/&γ;2
3.85	Consensus	class-d_on	Orthosteric Ligand	ste2_on
3.85	Consensus	gi_class-d	Orthosteric Ligand	gi_ste
3.85	Consensus	gi_ste	Orthosteric Ligand	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
3.57	Consensus	gs_vasopressin-ot	Orthosteric Ligand	7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
3.45	Single	6P9X	Corticoliberin	6P9X-CRF₁-Corticoliberin-Gs/&β;1/&γ;2
3.23	Single	7TYI	Amylin	7TYI-CT-Amylin-Gs/&β;1/&γ;2
3.03	Single	8F0K	Pramlintide analogue san385	8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3

Consensus Members
	Id	Members
	4XNW	4XNW-P2Y₁-MRS2500

Net Summary
I_min	4.34
Number of Linked Nodes	272
Number of Links	294
Number of Hubs	30
Number of Links mediated by Hubs	129
Number of Communities	8
Number of Nodes involved in Communities	46
Number of Links involved in Communities	56

Path Summary
Number Of Nodes in MetaPath	58
Number Of Links MetaPath	57
Number of Shortest Paths	60578
Length Of Smallest Path	3
Average Path Length	14.7261
Length of Longest Path	32
Minimum Path Strength	1.555
Average Path Strength	7.18409
Maximum Path Strength	27.195
Minimum Path Correlation	0.7
Average Path Correlation	0.922349
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.7619
Average % Of Corr. Nodes	48.3291
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	39.1067
Maximum Path Hubs %	100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following consensuses:
	Id	Components
	p2y_off	p2y1_off p2y12_off

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

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