Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
1NT 7.164581014
21x50 4.16021409
32x40 5.10802829
42x42 4.60708408
52x50 5.71667409
62x51 2.8125407
72x57 5.31458617
82x64 8.07479414
92x65 5.83617514
10E1 5.42875614
113x33 5.025416
123x36 4.18583517
133x44 4.39313407
143x49 5.42708409
153x55 8.43688446
16I2x53 5.73729407
174x46 3.72854468
184x50 5.11479469
194x52 1.24896405
20E2 13.32551914
215x39 6.05479417
225x43 6.25542616
235x50 2.87604408
245x51 4.32021406
255x58 5.59528639
265x60 6.32567544
276x30 4.4325407
286x37 4.01437408
296x48 4.50444618
30E3 6.34979411
317x47 4.16813407
327x52 3.54167409
337x53 5.3075539
348x49 5.20833426
35Lig 7.649461410
36I3 1.74733550
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
11x31 NT 34.97354.77NoYes124
21x31 7x36 22.37326.93083NoNo024
31x35 7x36 19.20195.07667NoNo054
41x35 7x39 16.02212.57667NoNo055
51x49 7x47 15.22823.69333NoYes087
61x49 7x50 18.84535.37NoNo089
71x50 7x50 20.0344.34667YesNo099
81x50 2x50 30.35027.40667YesYes099
92x50 7x49 33.63623.92667YesNo099
107x45 7x49 99.770810.5575NoNo099
116x48 7x45 1004.89667YesNo089
123x36 6x48 90.86824.00917YesYes178
133x36 Lig 84.97134.3725YesYes170
142x64 Lig 24.661410.8925YesYes140
152x64 NT 15.31737.84167YesYes144
162x65 Lig 16.91364.515YesYes140
172x65 NT 15.8314.74167YesYes144
18E2 Lig 38.492927.3458YesYes140
19E2 NT 20.314214.0042YesYes144
201x56 8x53 12.25642.35083NoNo087
211x60 8x53 13.30932.49833NoNo067
221x60 I1x50 24.05016.63333NoNo069
232x40 I1x50 24.44077.13083YesNo299
242x39 2x40 41.55812.5425NoYes089
252x39 3x49 42.54725.03167NoYes089
262x42 3x49 50.93613.58333YesYes089
272x42 4x46 58.04712.28417YesYes088
282x45 4x46 59.01087.58667NoYes698
292x45 3x42 63.01424.34667NoNo098
302x46 3x42 63.81246.25833NoNo098
312x46 7x49 94.35363.43417NoNo099
322x46 3x43 58.68394.615NoNo098
335x43 Lig 14.30699.90333YesYes160
343x40 5x51 29.2383.58417NoYes076
355x47 5x51 16.85844.27417NoYes086
365x43 5x47 16.786210.5367YesNo068
375x51 6x48 25.27285.90833YesYes068
383x40 5x50 27.45493.22833NoYes078
393x43 7x53 57.77126.0575NoYes089
405x58 7x53 47.45913.55667YesYes399
413x54 5x64 18.72213.84833NoNo095
423x54 5x61 19.71563.21NoNo099
435x61 6x37 20.86612.67833NoYes098
445x58 6x37 43.46428.30583YesYes098
451x60 I1x51 10.29082.41667NoNo068
46E2 E3 14.319712.2742YesYes141
475x69 6x30 10.11676.83333NoYes057
485x69 6x29 11.17382.6675NoNo056
496x29 6x33 19.9661.50833NoNo068
506x33 6x37 22.13541.38333NoYes088
516x47 7x45 10.28668.3975NoNo089
524x56 5x46 11.02534.33583NoNo056
535x46 5x50 14.73573.2375NoYes068
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
NTNT8.691671YesYes4422
E1NT9.905831YesYes4422
E2NT14.00421YesYes4412
2x64NT7.841671YesYes4412
7x31NT6.646671NoYes2422
2x572x617.94751YesNo7511
2x577x383.631671YesNo7611
2x57Lig8.996671YesYes7010
2x603x286.75750NoNo4612
2x60Lig4.10NoYes4010
2x612x659.994171NoYes5411
2x61Lig3.640831NoYes5010
2x642x658.954171YesYes4411
2x64Lig10.89251YesYes4010
2x65Lig4.5151YesYes4010
3x25E14.186671NoYes9422
3x22E212.80NoYes3421
3x25E211.50921NoYes9421
3x264x603.831671NoNo5622
3x26E24.498331NoYes5421
3x29E25.2351NoYes4411
3x29Lig5.10251NoYes4010
3x32Lig4.063331NoYes7010
3x335x434.143331YesYes6611
3x33Lig9.983331YesYes6010
3x366x484.009171YesYes7812
3x367x417.11YesNo7712
3x36Lig4.37251YesYes7010
3x375x435.456670NoYes6621
4x59E23.98750NoYes5421
4x605x399.385830NoYes6721
E2E245.29751YesYes4411
5x36E216.36921NoYes5421
5x37E27.358330NoYes3421
5x40E26.430830NoYes5421
6x58E210.51250NoYes4421
E2E312.27421YesYes4112
7x34E210.61671NoYes4411
E2Lig27.34581YesYes4010
5x365x383.911NoNo5522
5x39Lig3.633331YesYes7010
5x435x4710.53671YesNo6812
5x436x553.876671YesNo6612
5x43Lig9.903331YesYes6010
6x487x415.878331YesNo8722
6x547x346.71750NoNo4421
7x34Lig5.0751NoYes4010
7x38Lig5.468331NoYes6010
2x65NT4.741671YesYes4412
2x573x324.478331YesNo7711
2x577x423.351YesNo7712
2x64E14.610831YesYes4412
3x253x294.966671NoNo9421
3x334x573.091671YesNo6712
5x38E25.195831NoYes5421
5x39E27.584171YesYes7411
7x31E24.126671NoYes2421
5x395x433.615831YesYes7611
2x573x363.483331YesYes7711
3x303x332.881670NoYes6621
4x63E22.740830NoYes5421
2x563x322.348330NoNo5721
2x533x361.964170NoYes8721
2x657x350.9758331YesNo4412

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Consensuscb1_onOrthosteric Ligand8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
100.00Consensusgi_cannabinoidOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
85.71Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
85.71Consensuscb2_onOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
80.00Single5XR8AM8415XR8-CB1-AM841
80.00Single8GUSHU-3088GUS-CB2-HU-308-Gi1/&β;1/&γ;2
78.57Single7V3ZPubMed 1048957V3Z-CB1-PubMed 104895
78.57Consensuscb1_on_alloOrthosteric Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
75.00Single8WU1KCA8WU1-CB1-KCA-Arrestin1
73.33Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
73.33Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
72.22Single8GHVPubChem 1459649038GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
71.43Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
71.43Single8GURPubChem 1048958GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2
70.59Single8GAGYVF8GAG-CB1-YVF-Gi1/&β;1/&γ;2
70.59Single8WRZ8D08WRZ-CB1-8D0-Arrestin1
68.75Single7WV9PubMed 1048957WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
66.67Single5ZTYAM102575ZTY-CB2-AM10257
66.67Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2
66.67Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
64.71Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
64.71Single6KQIPubMed 1048956KQI-CB1-PubMed 104895-ORG27569
64.71Consensuscb1_off_alloOrthosteric Ligand6KQI-CB1-PubMed 104895-ORG27569
61.11Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/&β;1/&γ;2
60.00Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2
58.82Single5XRAAM115425XRA-CB1-AM11542
58.82Single7FEEPubMed 1048957FEE-CB1-PubMed 104895-ZCZ011
57.89Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
57.89Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
48.00Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
47.62Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
47.37Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/&β;1/&γ;2
47.37Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
47.06Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
47.06Consensusgi_hcaOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
47.06Consensusgi_hcarOrthosteric Ligandgi_hca
47.06Consensushca2_onOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
45.45Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
44.44Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
44.44Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
44.44Single8DZQmomSalB8DZQ-κ-momSalB-Go/&β;1/&γ;2
44.44Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
44.44Consensusgo_opioidOrthosteric Ligand8DZQ-κ-momSalB-Go/&β;1/&γ;2
43.75Single8EFOPZM218EFO-μ-PZM21-Gi1/&β;1/&γ;2
43.48Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
42.86Single7XY6PubChem 117178317XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
42.86Consensuslpl_offOrthosteric Ligands1p_off lpa_off
42.86Consensuslpl_onOrthosteric Ligands1p_on lpa_on
42.86Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
42.11Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
42.11Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
42.11Single7JVPSKF839597JVP-D1-SKF83959-Gs/&β;1/&γ;2
42.11Single8E0GBU728E0G-μ-BU72
42.11Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
41.18Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
41.18Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
41.18Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
41.18Single8JIMMMF8JIM-HCA2-MMF-Gi1/&β;1/&γ;2
41.18Single8K5CAcipimox8K5C-HCA2-Acipimox
41.18Consensusox2_offOrthosteric Ligand6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant
41.18Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
41.18Consensuss1p_offOrthosteric Ligands1p1_off
40.91Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
40.00Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
40.00Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
40.00Single7YITNalfurafine7YIT-κ-Nalfurafine
40.00Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
40.00Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
40.00Consensusopioid_offOrthosteric Ligandkop_off mop_off nop_off dop_off
40.00Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
39.13Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
39.13Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
39.13Consensusalpha1_offOrthosteric Ligandalpha1a_off alpha1b_off
39.13Consensuscx3cr_onOrthosteric Ligandcx3cr1_on
38.89Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
38.89Single7CRHSKF839597CRH-D1-SKF83959-Gs/&β;1/&γ;2
38.89Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
38.89Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
38.89Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
38.89Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/&β;1/&γ;2
38.89Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
38.89Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
38.46Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
38.10Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
38.10Single6DDFDamgo6DDF-μ-Damgo-Gi1/&β;1/&γ;2
38.10Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/&β;1/&γ;2
38.10Single7XK2MK68927XK2-HCA2-MK6892-Gi1/&β;1/&γ;2
38.10Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
38.10Consensusgs_orexinOrthosteric Ligand7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
38.10Consensusorexin_onOrthosteric Ligandox2_on
38.10Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
37.50Single6W25SHU91196W25-MC4-SHU9119-Ca
37.50Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
37.50Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
37.50Single8GGCEpinephrine8GGC-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
37.50Single8GGEEpinephrine8GGE-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
37.50Single8GH1Epinephrine8GH1-β2-Epinephrine
37.50Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2
37.50Single8K5BNiacin8K5B-HCA2-Niacin
37.50Consensuscx3cr1_onOrthosteric Ligand7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
37.50Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
37.04Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
36.84Single5C1MBU725C1M-μ-BU72
36.84Single6DDEDamgo6DDE-μ-Damgo-Gi1/&β;1/&γ;2
36.84Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
36.84Single7C4SS1P7C4S-S1P3-S1P
36.84Single7CKXA776367CKX-D1-A77636-Gs/&β;1/&γ;2
36.84Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
36.84Single7SBFPZM217SBF-μ-PZM21-Gi1/&β;1/&γ;2
36.84Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
36.84Single7YXAONO-54306087YXA-S1P5-ONO-5430608
36.84Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
36.84Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRR-D1-Rotigotine-Gs/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
36.36Single4UG2CGS216804UG2-A2A-CGS21680
36.36Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
36.36Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
36.36Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
36.36Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
36.36Single8IYHMK68928IYH-HCA2-MK6892-Go/&β;1/&γ;2
36.36Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
36.36Consensusclass-d_offOrthosteric Ligandste2_off
36.36Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
36.00Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
36.00Single8J6IMK68928J6I-HCA2-MK6892-Gi1/&β;1/&γ;2
35.71Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
35.71Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
35.48Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
35.29Single6AKXA4R6AKX-CCR5-A4R
35.29Single6AKYMaraviroc6AKY-CCR5-Maraviroc
35.29Single6B73PubChem 1319551386B73-κ-PubChem 131955138
35.29Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
35.29Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
35.29Single8GGFEpinephrine8GGF-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.29Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/&β;1/&γ;2
35.29Single8UO3Epinephrine8UO3-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
35.29Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
35.29Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
35.29Consensusorexin_offOrthosteric Ligandox2_off ox1_off
35.00Single3SN6BI1671073SN6-β2-BI167107-Gs/&β;1/&γ;2
35.00Single4DJHJDTic4DJH-κ-JDTic
35.00Single4RWADIPP-NH24RWA-δ-DIPP-NH2
35.00Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
35.00Single7CKYPW04647CKY-D1-PW0464-Gs/&β;1/&γ;2
35.00Single7EW7PubChem 40774607EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
35.00Single7JV5SKF812977JV5-D1-SKF81297-Gs/&β;1/&γ;2
35.00Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
35.00Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
35.00Single8DZPmomSalB8DZP-κ-momSalB-Gi1/&β;1/&γ;2
35.00Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
35.00Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
35.00Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2
35.00Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2
35.00Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
35.00Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/&β;1/&γ;2
35.00Single8X79MRE-2698X79-I2-MRE-269-Gs/&β;1/&γ;2
35.00Consensus5ht5_offOrthosteric Ligand5ht5a_off
35.00Consensuscck_onOrthosteric Ligandccka_on cckb_on
35.00Consensusffa4_onOrthosteric Ligand8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
35.00Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2
35.00Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
35.00Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
34.78Single4XT1Fractalkine4XT1-US28-Fractalkine
34.78Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
34.78Single7QA8Peptide7QA8-STE2-Peptide
34.78Single7QA8Peptide7QA8-STE2-Peptide
34.78Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
34.78Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
34.78Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
34.78Single8J6RMK68928J6R-HCA2-MK6892-Gi1/&β;1/&γ;2
34.78Consensusclass-d_offOrthosteric Ligandste2_off
34.78Consensusfpr-alx_onOrthosteric Ligandfpr1-alx_on fpr2-alx_on
34.78Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
34.78Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
34.78Consensusmop_offOrthosteric Ligand7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
34.78Consensussst_onOrthosteric Ligandsst2_on sst4_on
34.62Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
34.48Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
34.38Consensuspth_onOrthosteric Ligandpth1_on pth2_on
33.33Single4MBSMaraviroc4MBS-CCR5-Maraviroc
33.33Single4ZJCSB-6740424ZJC-OX1-SB-674042
33.33Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
33.33Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
33.33Single6TPGEMPA6TPG-OX2-EMPA
33.33Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
33.33Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
33.33Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
33.33Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
33.33Single7JOZVFP7JOZ-D1-VFP-Gs/&β;1/&γ;2
33.33Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/&β;1/&γ;2
33.33Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
33.33Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
33.33Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
33.33Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
33.33Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
33.33Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
33.33Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
33.33Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
33.33Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
33.33Single8GCPPGE28GCP-EP4-PGE2-Gi1/&β;1/&γ;2
33.33Single8GDZEpinephrine8GDZ-β2-Epinephrine-Gs/&β;1/&γ;2
33.33Single8GGTEpinephrine8GGT-β2-Epinephrine
33.33Single8I95EP548I95-C3aB-EP54-Go/&β;1/&γ;2
33.33Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2
33.33Single8IJDMK68928IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
33.33Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Single8JERAcipimox8JER-HCA2-Acipimox-Go/&β;1/&γ;2
33.33Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
33.33Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/&β;1/&γ;2
33.33Single8UO2Epinephrine8UO2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Consensusat2_offOrthosteric Ligand7JNI-AT2-Olodanrigan
33.33Consensusgs_tarOrthosteric Ligand8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Consensush3_on_alloOrthosteric Ligand7F61-H3-PF-03654746-Cholesterol
33.33Consensushca_onOrthosteric Ligandhca2_on hca3_on
33.33Consensushcar_onOrthosteric Ligandhca_on
33.33Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
33.33Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
33.33Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
33.33Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
33.33Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
33.33Consensusox1_offOrthosteric Ligand6TOT-OX1-Lemborexant 6TP4-OX1-ACT-462206 6TP6-OX1-Filorexant 6V9S-OX1-GTPL11403 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ7-OX1-SB-334867 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant
33.33Consensuspeptide_offOrthosteric Ligandopioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
32.35Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
32.35Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
32.14Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
32.14Consensusgo_class-b1Orthosteric Ligandgo_crf
32.14Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
32.00Single7F4DAlpha-MSH7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
32.00Consensusangiotensin_onOrthosteric Ligandat1_on
32.00Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
32.00Consensusgi_formylpeptideOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
32.00Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
31.82Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
31.82Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
31.82Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
31.82Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
31.82Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
31.82Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
31.82Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
31.82Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.82Single7UM4AS26747237UM4-5-HT5A-AS2674723
31.82Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
31.82Single7XJISolabegron7XJI-β3-Solabegron-Gs/&β;1/&γ;2
31.82Single7XZ6APD6687XZ6-GPR119-APD668-Gs/&β;1/&γ;2
31.82Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
31.82Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
31.82Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.82Consensus5ht5a_offOrthosteric Ligand7UM4-5-HT5A-AS2674723
31.82Consensusbeta1_off_alloOrthosteric Ligand4BVN-β1-Cyanopindolol-Na
31.82Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
31.82Consensusendothelin_offOrthosteric Ligandetb_off
31.82Consensusep4_onOrthosteric Ligand7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2
31.82Consensusetb_offOrthosteric Ligand5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500 5X93-ETB-K-8794
31.58Single2Y04Salbutamol2Y04-β1-Salbutamol
31.58Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
31.58Single4YAYZD-71554YAY-AT1-ZD-7155
31.58Single6DRXLisuride6DRX-5-HT2B-Lisuride
31.58Single6TOTLemborexant6TOT-OX1-Lemborexant
31.58Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
31.58Single7LJCPubChem 867641037LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
31.58Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/&β;1/&γ;2
31.58Single7UL4Alvimopan7UL4-μ-Alvimopan
31.58Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
31.58Single7VKTLTB47VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
31.58Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
31.58Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
31.58Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
31.58Single8GEBEpinephrine8GEB-β2-Epinephrine-Gs/&β;1/&γ;2
31.58Single8GEHEpinephrine8GEH-β2-Epinephrine-Gs/&β;1/&γ;2
31.58Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/&β;1/&γ;2
31.58Single8JLZST19368JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
31.58Single8K5DGSK2560738K5D-HCA2-GSK256073
31.58Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
31.58Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
31.58Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
31.58Consensusblt_onOrthosteric Ligandblt1_on
31.58Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
31.58Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
31.58Consensushca3_onOrthosteric Ligand8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
31.58Consensusleuko_onOrthosteric Ligandblt_on
31.58Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
31.58Consensustar_onOrthosteric Ligandta1_on
31.25Single3OE6IT1t3OE6-CXCR4-IT1t
31.25Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
31.25Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
31.25Single8GGREpinephrine8GGR-β2-Epinephrine
31.25Single8J6QBeta-hydroxybutyrate8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
31.25Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
31.03Single6IGLIRL16206IGL-ETB-IRL1620
31.03Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
31.03Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
31.03Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
30.77Single6JODAngiotensin II6JOD-AT2-Angiotensin II
30.77Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
30.77Single7C61Ergotamine7C61-5-HT1B-Ergotamine
30.77Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
30.77Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
30.77Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.77Single8IHFMK68928IHF-HCA2-MK6892-Gi1/&β;1/&γ;2
30.77Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
30.77Consensusgi_somatostatinOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
30.77Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
30.43Single3NY9PubChem 9131033NY9-β2-PubChem 913103
30.43Single5EE7MK08935EE7-Glucagon-MK0893
30.43Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
30.43Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.43Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
30.43Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
30.43Single7SK9CCX6627SK9-ACKR3-CCX662
30.43Single8INRAlpha-MSH8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
30.43Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.43Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
30.43Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2 8I95-C3aB-EP54-Go/&β;1/&γ;2
30.43Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
30.43Consensusfpr2-alx_onOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
30.43Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.43Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
30.00Single2Y03Isoprenaline2Y03-β1-Isoprenaline
30.00Single2YCW(S)-Carazolol2YCW-β1-(S)-Carazolol
30.00Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
30.00Single5D6L(S)-Carazolol5D6L-β2-(S)-Carazolol
30.00Single5TVNLSD5TVN-5-HT2B-LSD
30.00Single5WQCEMPA5WQC-OX2-EMPA
30.00Single5XPRBosentan5XPR-ETB-Bosentan
30.00Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
30.00Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
30.00Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
30.00Single6TP6Filorexant6TP6-OX1-Filorexant
30.00Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
30.00Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
30.00Single7CFNINT-7777CFN-GPBA-INT-777-Gs/&β;1/&γ;2
30.00Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
30.00Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
30.00Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
30.00Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
30.00Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
30.00Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
30.00Single7XKAEpinephrine7XKA-β2-Epinephrine
30.00Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
30.00Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
30.00Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
30.00Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2
30.00Single8GDAL9026888GDA-EP4-L902688-Gs/&β;1/&γ;2
30.00Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2
30.00Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
30.00Single8UNYEpinephrine8UNY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
30.00Consensusa1_on_alloOrthosteric Ligand7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
30.00Consensusadrenergic_offOrthosteric Ligandbeta_off alpha_off
30.00Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
30.00Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
30.00Consensusgs_adrenergicOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJI-β3-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
30.00Consensusgs_crfOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
30.00Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
30.00Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
29.73Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
29.63Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.63Single7KH0Acyclovir triphosphate7KH0-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
29.63Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
29.63Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
29.63Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
29.63Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
29.63Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
29.63Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
29.63Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
29.63Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
29.63Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
29.63Consensusgs_melanocortinOrthosteric Ligand7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2
29.41Single3OE9IT1t3OE9-CXCR4-IT1t
29.41Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
29.41Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2
29.41Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
29.41Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2
29.41Single8EF6Morphine8EF6-μ-Morphine-Gi1/&β;1/&γ;2
29.41Single8GEIEpinephrine8GEI-β2-Epinephrine-Gs/&β;1/&γ;2
29.41Single8GGSEpinephrine8GGS-β2-Epinephrine
29.41Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2
29.41Single8IJANiacin8IJA-HCA2-Niacin-Gi1/&β;1/&γ;2
29.41Single8JILNiacin8JIL-HCA2-Niacin-Gi1/&β;1/&γ;2
29.41Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
29.41Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
29.41Single8UNVEpinephrine8UNV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
29.41Consensusclass-t_onOrthosteric Ligandtaste2_on
29.41Consensusgs_class-tOrthosteric Ligandgs_taste
29.41Consensusgs_tasteOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
29.41Consensustaste2_onOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
29.17Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
29.17Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
29.17Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.17Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
29.17Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
29.17Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
29.17Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
29.17Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
29.17Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
29.17Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
29.17Consensussst2_onOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
29.17Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
29.03Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
29.03Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
29.03Consensusglp_onOrthosteric Ligandglp1_on glp2_on
28.57Single2YDVNECA2YDV-A2A-NECA
28.57Single3P0GBI1671073P0G-β2-BI167107
28.57Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
28.57Single4UHRCGS216804UHR-A2A-CGS21680
28.57Single4XT3Fractalkine4XT3-US28-Fractalkine
28.57Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
28.57Single5D5A(S)-Carazolol5D5A-β2-(S)-Carazolol
28.57Single5D5B(S)-Carazolol5D5B-β2-(S)-Carazolol
28.57Single5G53NECA5G53-A2A-NECA-Gs
28.57Single5X93K-87945X93-ETB-K-8794
28.57Single6FJ3PTH6FJ3-PTH1-PTH
28.57Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
28.57Single6H7JIsoprenaline6H7J-β1-Isoprenaline
28.57Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
28.57Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
28.57Single6NI3BI1671076NI3-β2-BI167107-Gs/&β;1/&γ;2
28.57Single6TQ7SB-3348676TQ7-OX1-SB-334867
28.57Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2
28.57Single7B6WCyclazosin7B6W-α1b-Cyclazosin
28.57Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2
28.57Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
28.57Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2
28.57Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
28.57Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
28.57Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
28.57Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
28.57Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2
28.57Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
28.57Single7XTQR3997XTQ-GPBA-R399-Gs/&β;1/&γ;2
28.57Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
28.57Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
28.57Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2
28.57Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.57Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
28.57Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
28.57Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
28.57Single8JXVClozapine8JXV-H4-Clozapine-Gi1/&β;1/&γ;2
28.57Single8JXWVUF68848JXW-H4-VUF6884-Gi1/&β;1/&γ;2
28.57Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
28.57Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
28.57Consensusa2_onOrthosteric Liganda2a_on a2b_on
28.57Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
28.57Consensusalpha1b_offOrthosteric Ligand7B6W-α1b-Cyclazosin
28.57Consensusangiotensin_offOrthosteric Ligandat1_off at2_off
28.57Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCZ-β1-Iodocyanopindolol
28.57Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
28.57Consensusclass-d_onOrthosteric Ligandste2_on
28.57Consensuscyslt1_off_ortoalloOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
28.57Consensusdopamine_offOrthosteric Ligandd3_off d2_off d4_off
28.57Consensusgi_dopamineOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
28.57Consensusgi_ffaOrthosteric Ligand8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
28.57Consensusgi_neuromedinOrthosteric Ligand7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
28.57Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A2A-NECA-Gs/&β;1/&γ;1 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
28.57Consensusgs_compl-peptideOrthosteric Ligand8I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.57Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
28.57Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
28.57Consensuslpa_offOrthosteric Ligandlpa1_off
28.57Consensuslpa_onOrthosteric Ligandlpa1_on
28.57Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
28.57Consensusrelaxin_onOrthosteric Ligandrxfp4_on
28.12Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
28.00Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
28.00Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
28.00Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
28.00Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
28.00Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
28.00Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
28.00Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
27.78Single3ODUIT1t3ODU-CXCR4-IT1t
27.78Single5WS3EMPA5WS3-OX2-EMPA
27.78Single5ZKQABT-4915ZKQ-PAF-ABT-491
27.78Single6OBA(S)-Alprenolol6OBA-β2-(S)-Alprenolol-GTPL11074
27.78Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
27.78Single6TODEMPA6TOD-OX1-EMPA-Na
27.78Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
27.78Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
27.78Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
27.78Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
27.78Single7TUZ7alpha,25-dihydroxycholesterol7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
27.78Single7XRRLemborexant7XRR-OX2-Lemborexant
27.78Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2
27.78Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2
27.78Single8GECEpinephrine8GEC-β2-Epinephrine-Gs/&β;1/&γ;2
27.78Single8GEFEpinephrine8GEF-β2-Epinephrine-Gs/&β;1/&γ;2
27.78Single8GG7Epinephrine8GG7-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
27.78Single8GGAEpinephrine8GGA-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
27.78Single8GGVEpinephrine8GGV-β2-Epinephrine
27.78Single8GGWEpinephrine8GGW-β2-Epinephrine
27.78Single8GGXEpinephrine8GGX-β2-Epinephrine
27.78Single8GH0Epinephrine8GH0-β2-Epinephrine
27.78Single8IHKAcifran8IHK-HCA3-Acifran
27.78Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2
27.78Single8UNOEpinephrine8UNO-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
27.78Single8UO0Epinephrine8UO0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
27.78Single8UO1Epinephrine8UO1-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
27.78Consensus5ht2c_onOrthosteric Ligand8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
27.78Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
27.78Consensusalpha1_onOrthosteric Ligandalpha1a_on
27.78Consensusalpha1a_onOrthosteric Ligand7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
27.78Consensusbeta2_off_alloOrthosteric Ligand6OBA-β2-(S)-Alprenolol-GTPL11074
27.78Consensusgi_nucleotideOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
27.78Consensusm2_on_alloOther Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
27.59Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
27.59Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
27.59Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
27.59Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
27.59Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
27.59Consensusgi_class-dOrthosteric Ligandgi_ste
27.59Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
27.27Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
27.27Single3D4STimolol Maleate3D4S-β2-Timolol Maleate
27.27Single4LDEBI1671074LDE-β2-BI167107
27.27Single4PY02MeSATP4PY0-P2Y12-2MeSATP
27.27Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
27.27Single6A93Risperidone6A93-5-HT2A-Risperidone
27.27Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
27.27Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
27.27Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
27.27Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
27.27Single6MXTSalmeterol6MXT-β2-Salmeterol
27.27Single6ZG4HTL00099366ZG4-M1-HTL0009936
27.27Single7DFPSpiperone7DFP-D2-Spiperone
27.27Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/&β;1/&γ;2
27.27Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
27.27Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
27.27Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
27.27Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
27.27Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
27.27Single7WCNAR2314537WCN-GPR119-AR231453-Gs/&β;1/&γ;2
27.27Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
27.27Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2
27.27Single8IBUErythromycin A8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.27Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
27.27Single8J6DEP1418J6D-C3aB-EP141-Go/&β;1/&γ;2
27.27Single8JJ8Formoterol8JJ8-β2-Formoterol
27.27Single8JJLOlodaterol8JJL-β2-Olodaterol
27.27Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
27.27Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
27.27Consensusdp_offOrthosteric Liganddp2_off
27.27Consensusep_onOrthosteric Ligandep4_on ep2_on ep3_on
27.27Consensusgi_prostanoidOrthosteric Ligand8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GDC-EP3-PGE2-Gi1/&β;1/&γ;2 8GCM-EP4-L902688-Gi1/&β;1/&γ;2
27.27Consensusgo_5htOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
27.27Consensusgpr119_onOrthosteric Ligand7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
27.27Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
27.27Consensusgs_bileacidOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
27.27Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
27.27Consensusgs_steroidOrthosteric Ligandgs_bileacid
27.27Consensusgs_trhOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
27.27Consensusleuko_offOrthosteric Ligandblt_off cyslt_off
27.27Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
27.27Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
26.92Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
26.92Single6PT2KGCHM076PT2-δ-KGCHM07
26.92Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
26.92Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1
26.92Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
26.92Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
26.92Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
26.92Consensusgi_chemerinOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
26.92Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.92Consensusmc5_onOrthosteric Ligand8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
26.67Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
26.67Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
26.67Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
26.67Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
26.67Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
26.67Single8FEGPRD_0025178FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
26.67Single8GEJEpinephrine8GEJ-β2-Epinephrine-Gs/&β;1/&γ;2
26.67Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
26.67Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
26.67Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
26.32Single4DKLBeta-funaltrexamine4DKL-μ-Beta-funaltrexamine
26.32Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
26.32Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
26.32Single6PS4ICI 118-5516PS4-β2-ICI 118-551
26.32Single6PS5(S)-Propranolol6PS5-β2-(S)-Propranolol
26.32Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
26.32Single6TPNHTL66416TPN-OX2-HTL6641
26.32Single6VI4JDTic6VI4-κ-JDTic
26.32Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
26.32Single6ZG9GSK10347026ZG9-M1-GSK1034702
26.32Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/&β;1/&γ;2
26.32Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
26.32Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
26.32Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
26.32Single7F0TDopamine7F0T-D1-Dopamine-Gs/&β;1/&γ;2
26.32Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/&β;1/&γ;2
26.32Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.32Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
26.32Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
26.32Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
26.32Single7XJJGalanin7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
26.32Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.32Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.32Single8GE1Epinephrine8GE1-β2-Epinephrine-Gs/&β;1/&γ;2
26.32Single8GE4Epinephrine8GE4-β2-Epinephrine-Gs/&β;1/&γ;2
26.32Single8GE6Epinephrine8GE6-β2-Epinephrine-Gs/&β;1/&γ;2
26.32Single8GE7Epinephrine8GE7-β2-Epinephrine-Gs/&β;1/&γ;2
26.32Single8GE8Epinephrine8GE8-β2-Epinephrine-Gs/&β;1/&γ;2
26.32Single8GE9Epinephrine8GE9-β2-Epinephrine-Gs/&β;1/&γ;2
26.32Single8GEGEpinephrine8GEG-β2-Epinephrine-Gs/&β;1/&γ;2
26.32Single8GFVEpinephrine8GFV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
26.32Single8GG4Epinephrine8GG4-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
26.32Single8GG8Epinephrine8GG8-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
26.32Single8GGIEpinephrine8GGI-β2-Epinephrine
26.32Single8GGKEpinephrine8GGK-β2-Epinephrine
26.32Single8GGMEpinephrine8GGM-β2-Epinephrine
26.32Single8GGPEpinephrine8GGP-β2-Epinephrine
26.32Single8GGQEpinephrine8GGQ-β2-Epinephrine
26.32Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2
26.32Single8JHNMMF8JHN-HCA2-MMF-Go/&β;1/&γ;2
26.32Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
26.32Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.32Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.32Single8UNQEpinephrine8UNQ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
26.32Single8UNZEpinephrine8UNZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
26.32Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/&β;1/&γ;2
26.32Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
26.32Consensus5ht5_onOrthosteric Ligand5ht5a_on
26.32Consensus5ht5a_onOrthosteric Ligand7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
26.32Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
26.32Consensusd1_on_alloOrthosteric Ligand7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
26.32Consensusd3_onOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
26.32Consensusgo_galaninOrthosteric Ligand7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
26.32Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
26.09Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
26.09Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
26.09Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
26.09Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
26.09Single6K1QIRL25006K1Q-ETB-IRL2500
26.09Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
26.09Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
26.09Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
26.09Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
26.09Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
26.09Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
26.09Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
26.09Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
26.09Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
26.09Single8ID8TUG-8918ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
26.09Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.09Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.09Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
26.09Consensusbileacid_onOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
26.09Consensusfpa_onOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.09Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
26.09Consensusgs_lipidOrthosteric Ligandgs_ffa gs_prostanoid
26.09Consensusgs_prostanoidOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.09Consensussteroid_onOrthosteric Ligandbileacid_on
25.93Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
25.93Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
25.93Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
25.93Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
25.93Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
25.93Consensusnmur_onOrthosteric Ligandnmur1_on nmur2_on
25.81Single5GLHEndothelin-15GLH-ETB-Endothelin-1
25.81Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
25.81Single6IGKEndothelin-36IGK-ETB-Endothelin-3
25.81Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
25.81Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
25.00Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
25.00Single3NY8ICI 118-5513NY8-β2-ICI 118-551
25.00Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
25.00Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
25.00Single4EJ4Naltrindole4EJ4-δ-Naltrindole
25.00Single4GBR(S)-Carazolol4GBR-β2-(S)-Carazolol
25.00Single4QKXPubChem 762106284QKX-β2-PubChem 76210628
25.00Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
25.00Single5DHGPubChem 250014125DHG-NOP-PubChem 25001412
25.00Single5JQH(S)-Carazolol5JQH-β2-(S)-Carazolol
25.00Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
25.00Single5TGZAM65385TGZ-CB1-AM6538
25.00Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
25.00Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
25.00Single6GPSMK08126GPS-CCR2-MK0812
25.00Single6H7MSalbutamol6H7M-β1-Salbutamol
25.00Single6IIVDaltroban6IIV-TP-Daltroban
25.00Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
25.00Single6PS0(S)-Carazolol6PS0-β2-(S)-Carazolol
25.00Single6PS1Timolol6PS1-β2-Timolol
25.00Single6PS2(S)-Alprenolol6PS2-β2-(S)-Alprenolol
25.00Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
25.00Single6PT3DPI-2876PT3-δ-DPI-287
25.00Single6TQ9SB-4081246TQ9-OX1-SB-408124
25.00Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
25.00Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
25.00Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
25.00Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
25.00Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
25.00Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
25.00Single7CFMP3957CFM-GPBA-P395-Gs/&β;1/&γ;2
25.00Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
25.00Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
25.00Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
25.00Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Single7SCGFH2107SCG-μ-FH210-Gi1/&β;1/&γ;2
25.00Single7T2GMitragynine pseudoindoxyl7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
25.00Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
25.00Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
25.00Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/&β;1/&γ;2
25.00Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
25.00Single7WC7Lisuride7WC7-5-HT2A-Lisuride
25.00Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
25.00Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
25.00Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
25.00Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
25.00Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
25.00Single7XN9L-054,5227XN9-SST2-L-054,522
25.00Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
25.00Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
25.00Single8EFQDamgo8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
25.00Single8GE3Epinephrine8GE3-β2-Epinephrine-Gs/&β;1/&γ;2
25.00Single8GEEEpinephrine8GEE-β2-Epinephrine-Gs/&β;1/&γ;2
25.00Single8GFWEpinephrine8GFW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.00Single8GFXEpinephrine8GFX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.00Single8GFYEpinephrine8GFY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.00Single8GFZEpinephrine8GFZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.00Single8GG0Epinephrine8GG0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.00Single8GG1Epinephrine8GG1-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.00Single8GG2Epinephrine8GG2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.00Single8GG6Epinephrine8GG6-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.00Single8GGBEpinephrine8GGB-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.00Single8GGJEpinephrine8GGJ-β2-Epinephrine
25.00Single8GGNEpinephrine8GGN-β2-Epinephrine
25.00Single8GGOEpinephrine8GGO-β2-Epinephrine
25.00Single8GGUEpinephrine8GGU-β2-Epinephrine
25.00Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
25.00Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
25.00Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2
25.00Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single8J18(3R)-3-hydroxydodecanoic acid8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
25.00Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/&β;1/&γ;2
25.00Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
25.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
25.00Single8UNMEpinephrine8UNM-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.00Single8UNNEpinephrine8UNN-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.00Single8UNPEpinephrine8UNP-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.00Single8UO4Epinephrine8UO4-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
25.00Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
25.00Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
25.00Single8X5YAstemizole8X5Y-H1-Astemizole
25.00Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-alpha-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
25.00Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
25.00Consensusadenosine_onOrthosteric Liganda1_on a2_on
25.00Consensusadrenergic_onOrthosteric Ligandbeta_on alpha_on
25.00Consensusalpha2_onOrthosteric Ligandalpha2a_on alpha2b_on
25.00Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
25.00Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
25.00Consensusamine_onOrthosteric Ligandadrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on
25.00Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
25.00Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
25.00Consensusdopamine_onOrthosteric Ligandd3_on d2_on d5_on d1_on
25.00Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
25.00Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
25.00Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
25.00Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
25.00Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
25.00Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
25.00Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Consensusgs_neuromedinOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Consensushca2_on_alloOrthosteric Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
25.00Consensushcar_offOrthosteric Ligandsuccinate_off
25.00Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
25.00Consensusnucleotide_onOrthosteric Ligandadenosine_on
25.00Consensusprostanoid_offOrthosteric Ligandep_off tp_off dp_off
25.00Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
25.00Consensustp_offOrthosteric Ligand6IIV-TP-Daltroban 6IIU-TP-Ramatroban
24.32Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
24.24Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
24.24Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
24.14Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
24.14Single7D3SSecretin7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
24.14Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
24.14Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
24.14Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
24.14Consensusbb1_onOrthosteric Ligand8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
24.14Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
24.14Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
24.00Single4AMJ(S)-Carvedilol4AMJ-β1-(S)-Carvedilol
24.00Single4IARErgotamine4IAR-5-HT1B-Ergotamine
24.00Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
24.00Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
24.00Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
24.00Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
24.00Single8G59TUG-8918G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
24.00Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
24.00Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
24.00Consensusnmur1_onOrthosteric Ligand7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
24.00Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
23.81Single2RH1(S)-Carazolol2RH1-β2-(S)-Carazolol
23.81Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
23.81Single5WIUNemonapride5WIU-D4-Nemonapride
23.81Single5WIVNemonapride5WIV-D4-Nemonapride-Na
23.81Single5X7D(S)-Carazolol5X7D-β2-(S)-Carazolol-PubChem 129318963
23.81Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
23.81Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
23.81Single5ZK3Quinuclidinyl benzilate hydrobromide5ZK3-M2-Quinuclidinyl benzilate hydrobromide
23.81Single6D26Fevipiprant6D26-DP2-Fevipiprant
23.81Single6E67BI1671076E67-β2-BI167107-Gs (fused)
23.81Single6GPXMK08126GPX-CCR2-MK0812
23.81Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
23.81Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
23.81Single6PS3(S)-Carvedilol6PS3-β2-(S)-Carvedilol
23.81Single6PS6Timolol6PS6-β2-Timolol
23.81Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
23.81Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
23.81Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
23.81Single7BVQ(S)-Carazolol7BVQ-β1-(S)-Carazolol
23.81Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2
23.81Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
23.81Single7WC6LSD7WC6-5-HT2A-LSD
23.81Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
23.81Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
23.81Single8ID9Eicosapentaenoic acid8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
23.81Single8J19PubChem 1270454228J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
23.81Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
23.81Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
23.81Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
23.81Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide 6DRX-5-HT2B-Lisuride
23.81Consensusalpha2a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
23.81Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
23.81Consensusamine_offOrthosteric Ligandadrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
23.81Consensusbeta2_offOrthosteric Ligand6PS2-β2-(S)-Alprenolol 6PS3-β2-(S)-Carvedilol 6PS5-β2-(S)-Propranolol 6PS6-β2-Timolol 2RH1-β2-(S)-Carazolol 6PS4-β2-ICI 118-551 3NY9-β2-PubChem 913103
23.81Consensusbeta2_onOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
23.81Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
23.81Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
23.81Consensusd4_offOrthosteric Ligand5WIU-D4-Nemonapride
23.81Consensusd4_off_alloOrthosteric Ligand5WIV-D4-Nemonapride-Na
23.81Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
23.81Consensusep_offOrthosteric Ligandep4_off
23.81Consensusgi_adrenergicOrthosteric Ligand7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
23.81Consensusgo_amineOrthosteric Ligandgo_adrenergic go_muscarinic go_5ht
23.53Single3OE8IT1t3OE8-CXCR4-IT1t
23.53Single6ME9Ramelteon6ME9-MT2-Ramelteon
23.53Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
23.53Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/&β;1/&γ;2
23.53Single8F76-8F76-OR51E2-Gs/&β;1/&γ;2
23.53Single8GGZEpinephrine8GGZ-β2-Epinephrine
23.53Single8POKHistamine8POK-H2-Histamine-Gs/&β;1/&γ;2
23.53Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
23.53Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.53Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
23.53Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
23.53Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
23.33Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
23.33Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
23.33Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
23.33Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
23.33Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.33Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
23.33Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
23.33Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
23.33Consensusendothelin_onOrthosteric Ligandetb_on eta_on
23.33Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
23.33Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
23.08Single3QAKUK-4320973QAK-A2A-UK-432097
23.08Single6HLOAprepitant6HLO-NK1-Aprepitant
23.08Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
23.08Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
23.08Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
23.08Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
23.08Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
23.08Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.08Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
22.86Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
22.73Single3UONQuinuclidinyl benzilate hydrobromide3UON-M2-Quinuclidinyl benzilate hydrobromide
22.73Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
22.73Single4U15Tiotropium4U15-M3-Tiotropium
22.73Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
22.73Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
22.73Single6J21Aprepitant6J21-NK1-Aprepitant
22.73Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
22.73Single6OL9Tiotropium6OL9-M5-Tiotropium
22.73Single6WGTLSD6WGT-5-HT2A-LSD
22.73Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
22.73Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
22.73Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
22.73Single7TUYGSK682753A7TUY-GPR183-GSK682753A
22.73Single7W6PW967W6P-α2a-W96-Go/&β;1/&γ;2
22.73Single7W7EW587W7E-α2a-W58-Go/&β;1/&γ;2
22.73Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.73Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2
22.73Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/&β;1/&γ;2
22.73Single8EFLSR170188EFL-μ-SR17018-Gi1/&β;1/&γ;2
22.73Single8G056-OAU8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
22.73Single8GDBPGE28GDB-EP4-PGE2-Gs/&β;1/&γ;2
22.73Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
22.73Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
22.73Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/&β;1/&γ;2
22.73Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/&β;1/&γ;2
22.73Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.73Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
22.73Consensus5ht1b_onOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
22.73Consensus5ht_offOrthosteric Ligand5ht2_off 5ht5_off 5ht1_off
22.73Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
22.73Consensusgi_amineOrthosteric Ligandgi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
22.73Consensusgi_muscarinicOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
22.73Consensusgo_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
22.73Consensusgs_ffaOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2 8GDB-EP4-PGE2-Gs/&β;1/&γ;2
22.73Consensush1_offOrthosteric Ligand3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole 8X63-H1-Mepyramine 8X64-H1-Desloratadine
22.73Consensushistamine_offOrthosteric Ligandh1_off
22.73Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl Scopolamine 5ZHP-M3-PubChem 134828589
22.73Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
22.73Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
22.73Consensusnpy_offOrthosteric Ligandnpy2_off npy1_off
22.73Consensuss1p2_onOrthosteric Ligand7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
22.73Consensussst4_onOrthosteric Ligand7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
22.58Single6LMLGlucagon6LML-Glucagon-Glucagon
22.58Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
22.58Single7VGXNeuropeptide Y7VGX-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
22.58Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
22.58Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
22.58Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
22.58Consensusgs_endothelinOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.22Single3OE0CVX153OE0-CXCR4-CVX15
22.22Single5WF5UK-4320975WF5-A2A-UK-432097
22.22Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
22.22Single7SRQLSD7SRQ-5-HT2B-LSD
22.22Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
22.22Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
22.22Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
22.22Single7XNACYN1548067XNA-SST2-CYN154806
22.22Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;2
22.22Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/&β;1/&γ;2
22.22Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2
22.22Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.22Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.22Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.22Single8GGYEpinephrine8GGY-β2-Epinephrine
22.22Single8HN8Histamine8HN8-H4-Histamine-Gi1/&β;1/&γ;2
22.22Single8IY9Niacin8IY9-HCA2-Niacin-Go/&β;1/&γ;2
22.22Single8UNXEpinephrine8UNX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.22Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
22.22Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/&β;1/&γ;2
22.22Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
22.22Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
22.22Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
22.22Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
22.22Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
22.22Consensusox1_off_alloOrthosteric Ligand6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na 6TO7-OX1-Suvorexant-Na
22.22Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
22.22Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
21.88Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
21.74Single4AMIBucindolol4AMI-β1-Bucindolol
21.74Single5CXVTiotropium5CXV-M1-Tiotropium
21.74Single5X33BIIL2605X33-BLT1-BIIL260
21.74Single6CM4Risperidone6CM4-D2-Risperidone
21.74Single6H7N(S)-Xamoterol6H7N-β1-(S)-Xamoterol
21.74Single6HLPNetupitant6HLP-NK1-Netupitant
21.74Single6IIURamatroban6IIU-TP-Ramatroban
21.74Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
21.74Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
21.74Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
21.74Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
21.74Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1
21.74Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
21.74Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2
21.74Single7K15MKD0467K15-BLT1-MKD046-Na
21.74Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.74Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
21.74Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
21.74Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.74Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.74Single7XMTJ-21567XMT-SST4-J-2156-Gi1/&β;1/&γ;2
21.74Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
21.74Single7Y24Octreotide7Y24-SST2-Octreotide-Go/&β;1/&γ;2
21.74Single7Y66BM2137Y66-C5a1-BM213-Gi1/&β;1/&γ;2
21.74Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
21.74Single8JWYPubChem 1684517108JWY-A2A-PubChem 168451710
21.74Single8JWZAB9288JWZ-A2A-AB928-Na
21.74Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
21.74Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
21.74Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
21.74Consensusbeta1_onOrthosteric Ligand7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
21.74Consensusblt1_offOrthosteric Ligand7K15-BLT1-MKD046-Na
21.74Consensusblt_offOrthosteric Ligandblt1_off
21.74Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
21.74Consensusgi_class-fOther Ligandgi_frizzled
21.74Consensusgi_frizzledOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
21.74Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
21.74Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
21.74Consensusprostanoid_onOrthosteric Ligandep_on fpa_on
21.43Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
21.43Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
21.43Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
21.43Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
21.43Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
21.43Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
21.43Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
21.43Consensusclass-d_onOrthosteric Ligandste2_on
21.43Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
21.43Consensusgi_class-dOrthosteric Ligandgi_ste
21.43Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
21.43Consensusnmur2_onOrthosteric Ligand7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.43Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
21.21Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
21.21Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
21.05Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
21.05Single2X72All-trans-retinal2X72-Rhodopsin-All-trans-retinal-Gt(CT)
21.05Single3PWHZM2413853PWH-A2A-ZM241385
21.05Single3VGAZM2413853VGA-A2A-ZM241385-Antibody
21.05Single4S0VSuvorexant4S0V-OX2-Suvorexant
21.05Single5DHHSB-6121115DHH-NOP-SB-612111
21.05Single5U09Taranabant5U09-CB1-Taranabant
21.05Single6KUXRS-799486KUX-α2a-RS-79948
21.05Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
21.05Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
21.05Single6ME2Ramelteon6ME2-MT1-Ramelteon
21.05Single6TPJSuvorexant6TPJ-OX2-Suvorexant
21.05Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
21.05Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2
21.05Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2
21.05Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/&β;1/&γ;2
21.05Single7F8YDevazepide7F8Y-CCKA-Devazepide
21.05Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
21.05Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
21.05Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
21.05Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
21.05Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
21.05Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
21.05Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
21.05Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
21.05Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
21.05Single7W0OElabela7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
21.05Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
21.05Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
21.05Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2
21.05Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
21.05Single8GEAEpinephrine8GEA-β2-Epinephrine-Gs/&β;1/&γ;2
21.05Single8GEDEpinephrine8GED-β2-Epinephrine-Gs/&β;1/&γ;2
21.05Single8GG9Epinephrine8GG9-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.05Single8GNGIstradefylline8GNG-A2A-Istradefylline
21.05Single8HOCImetit8HOC-H4-Imetit-Gi1/&β;1/&γ;2
21.05Single8IW4Spermidine8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2
21.05Single8IWESpermidine8IWE-TAAR9-Spermidine
21.05Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
21.05Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.05Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
21.05Single8UNLEpinephrine8UNL-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.05Single8UNTEpinephrine8UNT-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.05Single8UNUEpinephrine8UNU-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.05Single8UNWEpinephrine8UNW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.05Consensus5ht2_onOrthosteric Ligand5ht2a_on 5ht2c_on
21.05Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
21.05Consensusalpha2a_offOrthosteric Ligand6KUX-α2a-RS-79948
21.05Consensusgi_histamineOrthosteric Ligand8HN8-H4-Histamine-Gi1/&β;1/&γ;2 8HOC-H4-Imetit-Gi1/&β;1/&γ;2
21.05Consensusgs_5htOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2 7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2 7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.05Consensusgs_histamineOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.05Consensush4_onOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.05Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
21.05Consensusmelatonin_onOrthosteric Ligandmt1_on mt2_on
21.05Consensusmglu_onOther Ligandmglu2_on mglu4_on
20.83Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
20.83Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
20.83Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
20.83Single6H7LDobutamine6H7L-β1-Dobutamine
20.83Single6IBLArformoterol6IBL-β1-Arformoterol
20.83Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2
20.83Single7EZCUKA7EZC-A2A-UKA
20.83Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2
20.83Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
20.83Single8E9YPubChem 4466038E9Y-M3-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.83Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
20.83Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
20.83Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
20.83Consensusc5a1_off_ortoalloOrthosteric Ligand6C1Q-C5a1-PMX53-NDT9513727 6C1R-C5a1-PMX53-Avacopan; Na
20.83Consensuscckb_onOrthosteric Ligand7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
20.83Consensusep2_onOrthosteric Ligand7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
20.83Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.83Consensusgs_galaninOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.83Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.83Consensusot_onOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
20.69Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
20.69Consensusbk1_onOrthosteric Ligand7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.69Consensusbombesin_onOrthosteric Ligandbb2_on bb1_on
20.69Consensusgs_bradykininOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.59Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
20.59Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
20.59Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
20.00Single2YDOAdenosine2YDO-A2A-Adenosine
20.00Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
20.00Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
20.00Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
20.00Single5WF6UK-4320975WF6-A2A-UK-432097
20.00Single6A94Zotepine6A94-5-HT2A-Zotepine
20.00Single6DS0Ly2660976DS0-5-HT2B-Ly266097
20.00Single6IQLL7458706IQL-D4-L745870
20.00Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
20.00Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
20.00Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
20.00Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/&β;1/&γ;2
20.00Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
20.00Single6TP3Nemorexant6TP3-OX1-Nemorexant
20.00Single6V9SGTPL114036V9S-OX1-GTPL11403
20.00Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
20.00Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
20.00Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
20.00Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
20.00Single7AROLUF58337ARO-A2A-LUF5833-Na
20.00Single7CMVPD1289077CMV-D3-PD128907-Gi1/&β;1/&γ;2
20.00Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
20.00Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
20.00Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
20.00Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
20.00Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Single7SK3CXCL127SK3-ACKR3-CXCL12
20.00Single7T32ZM2413857T32-A2A-ZM241385
20.00Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
20.00Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2
20.00Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
20.00Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
20.00Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
20.00Single7XOVSR1461317XOV-CCKA-SR146131-Gs/&β;1/&γ;2
20.00Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
20.00Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
20.00Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
20.00Single8GG3Epinephrine8GG3-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
20.00Single8GG5Epinephrine8GG5-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
20.00Single8GGLEpinephrine8GGL-β2-Epinephrine
20.00Single8JLNT1AM8JLN-TA1-T1AM-Gs/&β;1/&γ;2
20.00Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2
20.00Single8K2WAMG4878K2W-CXCR3-AMG487
20.00Single8SAI1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
20.00Single8UHBRO52563908UHB-TA1-RO5256390-Gs/&β;1/&γ;2
20.00Single8UNREpinephrine8UNR-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
20.00Single8UNSEpinephrine8UNS-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
20.00Single8WCCCyclohexylammonium ion8WCC-TA1-Cyclohexylammonium ion
20.00Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/&β;1/&γ;2
20.00Single8XZFWN5618XZF-Apelin-WN561-Gi1/&β;1/&γ;2
20.00Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
20.00Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6WH4-5-HT2A-Methiothepin 7VOE-5-HT2A-Aripiprazole 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 6A93-5-HT2A-Risperidone
20.00Consensus5ht2a_onOrthosteric Ligand7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Consensusalpha2b_onOrthosteric Ligand6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
20.00Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
20.00Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
20.00Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
20.00Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
20.00Consensusdop_off_alloOrthosteric Ligand4N6H-δ-Naltrindole-Na
20.00Consensusffa2_onOrthosteric Ligand8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
20.00Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
20.00Consensusgi_melatoninOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
20.00Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
20.00Consensusgo_vasopressinOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
20.00Consensusgs_bombesinOrthosteric Ligand8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Consensusm1_off_alloOrthosteric Ligand6WJC-M1-Atropine-Muscarinic toxin 7
20.00Consensusm1_off_alloOther Ligand6WJC-M1-Atropine-Muscarinic toxin 7
20.00Consensusmotilin_onOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
19.44Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
19.44Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
19.35Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
19.35Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
19.35Consensusetb_onOrthosteric Ligand8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
19.35Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
19.23Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
19.23Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
19.23Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
19.23Single7F8XNN90567F8X-CCKA-NN9056
19.23Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
19.23Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
19.05Single2Y01Dobutamine2Y01-β1-Dobutamine
19.05Single2Y02Carmoterol2Y02-β1-Carmoterol
19.05Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
19.05Single3NYA(S)-Alprenolol3NYA-β2-(S)-Alprenolol
19.05Single4DAJTiotropium4DAJ-M3-Tiotropium
19.05Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
19.05Single4MQSIperoxo4MQS-M2-Iperoxo
19.05Single4U14Tiotropium4U14-M3-Tiotropium
19.05Single4U16N-Methyl Scopolamine4U16-M3-N-Methyl Scopolamine
19.05Single4X1HNonyl Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
19.05Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
19.05Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
19.05Single5UENDU1725UEN-A1-DU172
19.05Single5UIGJ3.651.884G5UIG-A2A-J3.651.884G
19.05Single5YC8N-Methyl Scopolamine5YC8-M2-N-Methyl Scopolamine
19.05Single5ZK8N-Methyl Scopolamine5ZK8-M2-N-Methyl Scopolamine
19.05Single5ZKCN-Methyl Scopolamine5ZKC-M2-N-Methyl Scopolamine
19.05Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
19.05Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/&β;1/&γ;2
19.05Single6PRZ(S)-Alprenolol6PRZ-β2-(S)-Alprenolol
19.05Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
19.05Single7BU7BI1671077BU7-β1-BI167107
19.05Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
19.05Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
19.05Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
19.05Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
19.05Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
19.05Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
19.05Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
19.05Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2
19.05Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
19.05Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
19.05Single8CU6LJ-45178CU6-A2A-LJ-4517
19.05Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
19.05Single8EJKTAK-8758EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
19.05Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
19.05Single8JJOAlprenolol8JJO-β2-Alprenolol
19.05Single8X63Mepyramine8X63-H1-Mepyramine
19.05Single8X64Desloratadine8X64-H1-Desloratadine
19.05Consensus5ht1a_onOrthosteric Ligand8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
19.05Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
19.05Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
19.05Consensuscck_offOrthosteric Ligandccka_off
19.05Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
19.05Consensusffa_onOrthosteric Ligandffa4_on ffa1_on ffa2_on ffa3_on
19.05Consensusgi_5htOrthosteric Ligand7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
19.05Consensusgo_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
19.05Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
19.05Consensushistamine_onOrthosteric Ligandh1_on h4_on
19.05Consensusm2_on_alloOrthosteric Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
19.05Consensusm4_on_alloOrthosteric Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
19.05Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
19.05Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
19.05Consensusp2y12_offOrthosteric Ligand4NTJ-P2Y12-AZD1283 7PP1-P2Y12-Selatogrel
18.75Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
18.75Single8IY6Endothelin-18IY6-ETB-Endothelin-1
18.75Consensuscrf1_onOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
18.75Consensusgabab_offOther Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
18.75Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
18.52Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
18.52Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
18.52Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
18.52Consensussst_offOrthosteric Ligandsst2_off
18.18Single2Y00Dobutamine2Y00-β1-Dobutamine
18.18Single4NTJAZD12834NTJ-P2Y12-AZD1283
18.18Single4PHUFasiglifam4PHU-FFA1 (GPR40)-Fasiglifam
18.18Single5N2RPubChem 92460631; psb365N2R-A2A-PubChem 92460631; psb36-Na
18.18Single5N2SPSB365N2S-A1-PSB36
18.18Single5NM2ZM2413855NM2-A2A-ZM241385-Na
18.18Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
18.18Single6GDGNECA6GDG-A2A-NECA-Gs/&β;1/&γ;1
18.18Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
18.18Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2
18.18Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
18.18Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.18Single7Y27Somatostatin-147Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.18Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.18Single8EA0Iperoxo8EA0-M3-Iperoxo
18.18Single8FN1Neurotensin/neuromedin N8FN1-NTS1-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
18.18Single8GDCPGE28GDC-EP3-PGE2-Gi1/&β;1/&γ;2
18.18Single8JPCNeurotensin 8-138JPC-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
18.18Single8QOTNanobody E8QOT-μ-Nanobody E
18.18Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.18Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.18Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
18.18Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
18.18Consensusa2a_onOrthosteric Ligand6GDG-A2A-NECA-Gs/&β;1/&γ;1
18.18Consensusccr2_off_alloOther Ligand5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
18.18Consensusep3_onOrthosteric Ligand8GDC-EP3-PGE2-Gi1/&β;1/&γ;2
18.18Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
18.18Consensusgs_muscarinicOrthosteric Ligand8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.18Consensusgs_sstOrthosteric Ligand7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.18Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
18.18Consensusm2_offOrthosteric Ligand5ZKB-M2-AF-DX 384 5ZKC-M2-N-Methyl Scopolamine 5ZK3-M2-Quinuclidinyl benzilate hydrobromide
18.18Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.86Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
17.86Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.86Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
17.86Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.65Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
17.65Single8A2OTheophylline8A2O-A2A-Theophylline-Na
17.65Single8IWM2-Phenylethylamine8IWM-TAAR9-2-Phenylethylamine
17.65Single8WC5Tetramethylammonium ion8WC5-TA1-Tetramethylammonium ion-chim(NtGi1-Gs)/&β;1/&γ;2
17.50Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
17.39Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
17.39Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
17.39Single4BV0Neurotensin4BV0-NTS1-Neurotensin
17.39Single5TZR-5TZR-FFA1 (GPR40)-MK8666
17.39Single5V54Methiothepin5V54-5-HT1B-Methiothepin
17.39Single6E59L-7607356E59-NK1-L-760735
17.39Single6J20Aprepitant6J20-NK1-Aprepitant
17.39Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
17.39Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
17.39Single6OS1TRV0266OS1-AT1-TRV026
17.39Single7EPENAM5637EPE-mGlu-NAM563
17.39Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2
17.39Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1
17.39Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/&β;1/&γ;1
17.39Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
17.39Single7W41PD1762527W41-BB2-PD176252
17.39Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.39Single7XOWGastrin7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
17.39Single7XOXCholecystokinin-87XOX-CCKB-Cholecystokinin-8-Gq/&β;1/&γ;2
17.39Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.39Single8FMZNeurotensin/neuromedin N8FMZ-NTS1-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.39Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.39Single8JD0J9R8JD0-mGlu2; mGlu3-Glutamate-J9R
17.39Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
17.39Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
17.39Consensus5ht1_offOrthosteric Ligand5ht1b_off
17.39Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
17.39Consensusadenosine_offOrthosteric Liganda1_off a2_off
17.39Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
17.39Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
17.39Consensusbombesin_offOrthosteric Ligandbb2_off
17.39Consensuschemerin_onOrthosteric Ligandcml1_on
17.39Consensuscml1_onOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
17.39Consensusnk1_offOrthosteric Ligand6J20-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
17.39Consensusnts1_on_alloOrthosteric Ligand8JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
17.24Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
17.24Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
17.24Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
17.24Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
17.24Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
17.24Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.24Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
17.24Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
17.14Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
16.67Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
16.67Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
16.67Single4GRVNeurotensin 8-134GRV-NTS1-Neurotensin 8-13
16.67Single4N4WSANT-14N4W-SMO-SANT-1
16.67Single4XEENeurotensin4XEE-NTS1-Neurotensin
16.67Single4XESNeurotensin4XES-NTS1-Neurotensin
16.67Single5WKTOctyl Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
16.67Single6FUFAll-trans-retinal6FUF-Rhodopsin-All-trans-retinal-Go/&β;1/&γ;2
16.67Single6ME5Agomelatine6ME5-MT1-Agomelatine
16.67Single6OS2TRV0266OS2-AT1-TRV026
16.67Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/&β;1/&γ;2
16.67Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
16.67Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
16.67Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single6YVRNTS8-136YVR-NTS1-NTS8-13
16.67Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
16.67Single7MT8All-trans-retinal7MT8-Rhodopsin-All-trans-retinal-GRK1
16.67Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
16.67Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
16.67Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/&β;1/&γ;2
16.67Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
16.67Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
16.67Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67Single8EITDoconexent8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
16.67Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2
16.67Single8IW72-Phenylethylamine8IW7-TAAR9-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
16.67Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
16.67Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
16.67Single8JPBNeurotensin 8-138JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
16.67Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/&β;1/&γ;2
16.67Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg3_on
16.67Consensuschemokine_offOrthosteric Ligandcxcr_off
16.67Consensusclass-b2_onOrthosteric Ligandadgrg_on
16.67Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II
16.67Consensuscxcr_offOrthosteric Ligandcxcr4_off
16.67Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
16.13Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
16.13Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
16.00Single4BUONeurotensin4BUO-NTS1-Neurotensin
16.00Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
16.00Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
16.00Single7CX2PGE27CX2-EP2-PGE2-Gs/&β;1/&γ;2
16.00Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
16.00Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
16.00Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
16.00Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
16.00Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.00Consensusadgrg2_onOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
16.00Consensuscyslt2_offOrthosteric Ligand6RZ6-CysLT2-ONO-2570366 6RZ9-CysLT2-ONO-2770372 6RZ8-CysLT2-ONO-2080365
16.00Consensuscyslt_offOrthosteric Ligandcyslt2_off
16.00Consensusffa4_on_alloOrthosteric Ligand8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.00Consensusgi_neurotensinOrthosteric Ligand7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
15.79Single3PBLEticlopride3PBL-D3-Eticlopride
15.79Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
15.79Single5L7IVismodegib5L7I-SMO-Vismodegib
15.79Single6HLLCP999946HLL-NK1-CP99994
15.79Single6QNOAll-trans-retinal6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
15.79Single6TP4ACT-4622066TP4-OX1-ACT-462206
15.79Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
15.79Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
15.79Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
15.79Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
15.79Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
15.79Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/&β;1/&γ;2
15.79Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
15.79Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/&β;1/&γ;2
15.79Single8ITFDMCHA8ITF-TAAR9-DMCHA-chim(NtGi1-Gs)/&β;1/&γ;2
15.79Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
15.79Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
15.79Single8X2K5YM8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
15.79Consensus5ht4_onOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
15.79Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
15.79Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
15.79Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
15.79Consensusm4_on_alloOther Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
15.79Consensusmt1_onOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
15.79Consensusmt2_onOrthosteric Ligand7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
15.62Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
15.38Consensusgs_adgrOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
15.38Consensusgs_class-b2Orthosteric Ligandgs_adgr
15.15Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
15.15Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
15.00Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
15.00Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
15.00Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
15.00Single4BWBNeurotensin4BWB-NTS1-Neurotensin
15.00Single5K2DZM2413855K2D-A2A-ZM241385
15.00Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
15.00Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/&β;1/&γ;2
15.00Single6JZHZM2413856JZH-A2A-ZM241385-Na
15.00Single6NWEOctyl Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
15.00Single6OYAAll-trans-retinal6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
15.00Single6PS7ZM2413856PS7-A2A-ZM241385-Na
15.00Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
15.00Single7BR3Elagolix7BR3-GnRH1-Elagolix
15.00Single7F8ULintitript7F8U-CCKA-Lintitript
15.00Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
15.00Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;1
15.00Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
15.00Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
15.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
15.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
15.00Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
15.00Single8DWHCompound-168DWH-MRGPRX1-Compound-16-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.00Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/&β;1/&γ;2
15.00Single8HMPPubChem 699214798HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
15.00Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
15.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
15.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
15.00Consensusa2a_off_alloOrthosteric Ligand6ZDR-A2A-HMS1413f12-Na 6GT3-A2A-Imaradenant-Na 8CU7-A2A-LJ-4517-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PubChem 92460631; psb36-Na 5MZJ-A2A-Theophylline-Na 5OLO-A2A-Tozadenant-Na 5OLH-A2A-Vipadenant-Na 5NM4-A2A-ZM241385-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5MZP-A2A-Caffeine-Na 8CIC-A2A-Etrumadenant-Na
15.00Consensusalpha2_offOrthosteric Ligandalpha2a_off alpha2c_off
15.00Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
15.00Consensusffa3_on_alloOrthosteric Ligand8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
15.00Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
15.00Consensusgt_class-aOrthosteric Ligandgt_opsin
15.00Consensusgt_opsinOrthosteric Ligandgt_sensory
15.00Consensusgt_sensoryOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
15.00Consensusp2y_offOrthosteric Ligandp2y1_off p2y12_off
14.81Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/&β;1/&γ;1
14.81Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
14.81Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.81Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
14.71Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
14.71Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
14.29Single3REYPubChem 56973REY-A2A-PubChem 5697
14.29Single3RZECidoxepin3RZE-H1-Cidoxepin
14.29Single3UZCPubChem 1355666093UZC-A2A-PubChem 135566609
14.29Single5IU4ZM2413855IU4-A2A-ZM241385-Na
14.29Single5IU7Q274563465IU7-A2A-Q27456346-Na
14.29Single5IUBQ274563445IUB-A2A-Q27456344-Na
14.29Single5JTBZM2413855JTB-A2A-ZM241385
14.29Single5K2BZM2413855K2B-A2A-ZM241385-Na
14.29Single5K2CZM2413855K2C-A2A-ZM241385-Na
14.29Single5NLXZM2413855NLX-A2A-ZM241385-Na
14.29Single5NM4ZM2413855NM4-A2A-ZM241385-Na
14.29Single5TE3Octyl Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
14.29Single6AQFZM2413856AQF-A2A-ZM241385
14.29Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
14.29Single6MH8ZM2413856MH8-A2A-ZM241385
14.29Single6TPKRetosiban6TPK-OT-Retosiban
14.29Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
14.29Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
14.29Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
14.29Single7BB6Acyclovir triphosphate7BB6-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
14.29Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
14.29Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2
14.29Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
14.29Single7SK5CXCL127SK5-ACKR3-CXCL12
14.29Single7VVOPTH7VVO-PTH1-PTH-Gs/&β;1/&γ;2
14.29Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
14.29Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
14.29Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
14.29Single8GCML9026888GCM-EP4-L902688-Gi1/&β;1/&γ;2
14.29Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Single8HQN9(S)-HODE8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
14.29Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Single8K4NVF08K4N-GPR34-VF0-Gi1/&β;1/&γ;2
14.29Single8T3VDHA8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.29Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
14.29Consensuscxcr_onOrthosteric Ligandcxcr1_on cxcr2_on
14.29Consensusgnrh_offOrthosteric Ligandgnrh1_off
14.29Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
14.29Consensussensory_offOrthosteric Ligandopsin_off
14.29Consensusvasopressin-ot_offOrthosteric Ligandot_off
14.29Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
13.64Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
13.64Single3EMLZM2413853EML-A2A-ZM241385
13.64Single4EIYZM2413854EIY-A2A-ZM241385-Na
13.64Single4QIMPubChem 249053754QIM-SMO-PubChem 24905375
13.64Single5DSGTiotropium5DSG-M4-Tiotropium
13.64Single5IU8Q274563475IU8-A2A-Q27456347-Na
13.64Single5K2AZM2413855K2A-A2A-ZM241385-Na
13.64Single5OLGZM2413855OLG-A2A-ZM241385-Na
13.64Single5T04Neurotensin5T04-NTS1-Neurotensin
13.64Single5VRAZM2413855VRA-A2A-ZM241385-Na
13.64Single6D27CAY104716D27-DP2-CAY10471
13.64Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
13.64Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
13.64Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
13.64Single6LPJZM2413856LPJ-A2A-ZM241385-Na
13.64Single6LPKZM2413856LPK-A2A-ZM241385-Na
13.64Single6S0LZM2413856S0L-A2A-ZM241385
13.64Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.64Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
13.64Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
13.64Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
13.64Single7F83PF-051904577F83-Ghrelin-PF-05190457
13.64Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
13.64Single7PYRPSB-21157PYR-A2A-PSB-2115
13.64Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
13.64Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
13.64Single8EJCTAK-8758EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
13.64Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
13.64Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
13.64Consensusa2_offOrthosteric Liganda2a_off
13.64Consensusa2a_offOrthosteric Ligand8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 5UIG-A2A-J3.651.884G 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-PubChem 168451710 5K2D-A2A-ZM241385
13.64Consensusffa1_onOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.64Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
13.64Consensustachykinin_offOrthosteric Ligandnk1_off
13.33Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
13.33Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
13.04Single4JKVTaladegib (LY2940680)4JKV-SMO-Taladegib (LY2940680)
13.04Single4WW3All-trans-retinal4WW3-Rhodopsin-All-trans-retinal
13.04Single5CGCHTL142425CGC-mGlu5-HTL14242
13.04Single5IUAQ274563485IUA-A2A-Q27456348-Na
13.04Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
13.04Single6LPLZM2413856LPL-A2A-ZM241385-Na
13.04Single6LUQHaloperidol6LUQ-D2-Haloperidol
13.04Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
13.04Single6S0QZM2413856S0Q-A2A-ZM241385
13.04Single6WQAZM2413856WQA-A2A-ZM241385-Na
13.04Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
13.04Single7RM5ZM2413857RM5-A2A-ZM241385-Na
13.04Single7SINNPS-21437SIN-CaS-NPS-2143
13.04Single7SINNPS-21437SIN-CaS-NPS-2143
13.04Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
13.04Single8FYNZM2413858FYN-A2A-ZM241385-Na
13.04Single8GNEKW-63568GNE-A2A-KW-6356-Na
13.04Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
12.90Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
12.82Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
12.50Single5V56TC1145V56-SMO-TC114
12.50Single5V57TC1145V57-SMO-TC114
12.50Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
12.50Single6W25Ca6W25-MC4-SHU9119-Ca
12.50Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
12.50Single7F1TMIP-1a7F1T-CCR5-MIP-1a
12.50Single7PX4PSB-21137PX4-A2A-PSB-2113
12.50Single8WCBCyclohexylammonium ion8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50Consensusghrh_onOrthosteric Ligand7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
12.50Consensusmglu2_onOther Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
12.50Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
12.20Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
12.12Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
12.12Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
12.00Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
12.00Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/&β;1/γ1
12.00Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.00Consensusnts1_onOrthosteric Ligand6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
12.00Consensusnts_onOrthosteric Ligandnts1_on
11.76Single3PXOAll-trans-retinal3PXO-Rhodopsin-All-trans-retinal
11.76Single5DYSAll-trans-retinal5DYS-Rhodopsin-All-trans-retinal
11.76Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
11.76Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
11.76Single7WC4Serotonin7WC4-5-HT2A-Serotonin
11.76Single7XKEBetahydroxyandrosterone7XKE-ADGRG2-Betahydroxyandrosterone-chim(NtGi1-Gs)/&β;1/&γ;2
11.76Single8PWNTheophylline8PWN-A2A-Theophylline
11.76Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
11.76Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
11.54Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
11.54Single5CGDHTL142425CGD-mGlu5-HTL14242
11.54Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/&β;1/&γ;2
11.54Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
11.11Single2HPYAll-trans-retinal2HPY-Rhodopsin-All-trans-retinal
11.11Single3RFMCaffeine3RFM-A2A-Caffeine
11.11Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
11.11Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
11.11Single7MTBAll-trans-retinal7MTB-Rhodopsin-All-trans-retinal-GRK1
11.11Single7XKDBetahydroxyandrosterone7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
11.11Consensussensory_onOrthosteric Ligandopsin_on
10.81Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
10.71Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
10.53Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
10.53Single3PQRAll-trans-retinal3PQR-Rhodopsin-All-trans-retinal-Gt(CT)
10.53Single4XNWMRS25004XNW-P2Y1-MRS2500
10.53Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
10.53Single6LI0GTPL98046LI0-GPR52-GTPL9804
10.53Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2
10.53Single7MT9All-trans-retinal7MT9-Rhodopsin-All-trans-retinal-GRK1
10.53Single7MTAAll-trans-retinal7MTA-Rhodopsin-All-trans-retinal-GRK1
10.53Single7WC5Psilocin7WC5-5-HT2A-Psilocin
10.53Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
10.53Consensusopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
10.53Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
10.53Consensussmo_off_alloOrthosteric Ligand6D32-SMO-Cyclopamine-Cyclopamine
10.34Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.00Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
10.00Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
10.00Single2G87All-trans-retinal2G87-Rhodopsin-All-trans-retinal
10.00Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
10.00Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
10.00Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
10.00Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
10.00Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
10.00Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
10.00Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
10.00Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
10.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
10.00Single7XKFBetahydroxyandrosterone7XKF-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
10.00Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
10.00Consensusgo_adhesionOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
10.00Consensusgo_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
10.00Consensusgo_class-b2Orthosteric Ligandgo_adhesion
10.00Consensusgo_proteinOrthosteric Ligandgo_chemokine
10.00Consensussmo_on_alloOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
9.52Single3VG9ZM2413853VG9-A2A-ZM241385-Antibody
9.52Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
9.52Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
9.52Single6WWZCCL206WWZ-CCR6-CCL20-Go/&β;1/&γ;2
9.52Single8A6CAll-trans-retinal8A6C-Rhodopsin-All-trans-retinal
9.52Single8A6DAll-trans-retinal8A6D-Rhodopsin-All-trans-retinal
9.52Single8A6EAll-trans-retinal8A6E-Rhodopsin-All-trans-retinal
9.52Single8FN0Neurotensin/neuromedin N8FN0-NTS1-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
9.52Single8U8FPML8U8F-GPR3-PML-Gs/&β;1/&γ;2
9.52Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
9.52Consensusclass-f_offOrthosteric Ligandsmo_off
9.52Consensusopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
9.38Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
9.09Single5UVIZM2413855UVI-A2A-ZM241385
9.09Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
9.09Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
9.09Single6ZDVPubChem 9840736ZDV-A2A-PubChem 984073-Na
9.09Single6ZINSR486926ZIN-NTS1-SR48692
9.09Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
9.09Single7VODCariprazine7VOD-5-HT2A-Cariprazine
8.70Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
8.70Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/&β;1/&γ;2
8.70Consensusfsh_on_alloOther Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
8.70Consensussmo_offOrthosteric Ligand5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
8.57Consensuscalcitonin_onOrthosteric Ligandct_on ctlike_on
8.33Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
8.33Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
8.33Single6Z4SSR486926Z4S-NTS1-SR48692
8.33Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
8.33Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
8.00Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
8.00Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
8.00Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
8.00Single7P2L4YI7P2L-mGlu5-4YI
8.00Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
8.00Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
8.00Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
8.00Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
7.69Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
7.69Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
7.69Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.69Consensusnts1_offOrthosteric Ligand6Z4Q-NTS1-SR142948A 6Z4S-NTS1-SR48692
7.69Consensusnts_offOrthosteric Ligandnts1_off
7.69Consensustsh_on_alloOther Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
7.14Single6KNMJN241-96KNM-Apelin-JN241-9
7.14Consensusclass-c_offOther Ligandgabab_off mglu_off
6.82Consensusgs_ctOrthosteric Ligand7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
6.67Single7SHEPI; PE7SHE-GPR158-PI; PE
5.88Single4A4MAll-trans-retinal4A4M-Rhodopsin-All-trans-retinal-Gt(CT)
5.88Single5EN0All-trans-retinal5EN0-Rhodopsin-All-trans-retinal-Gt(CT)
5.88Single5MZPCaffeine5MZP-A2A-Caffeine-Na
5.88Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
5.88Consensusccr8_offOrthosteric Ligand8TLM-CCR8-Anti-murine CCR8 antibody
5.88Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
5.56Single6VCBLSN31604406VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
5.56Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
5.56Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/&β;1/&γ;2
5.56Consensusclass-c_onOther Ligandgabab_on mglu_on
5.41Single7TYIAmylin7TYI-CT-Amylin-Gs/&β;1/&γ;2
5.41Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
5.26Single6OY9All-trans-retinal6OY9-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
5.26Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
5.26Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
5.26Single7VDMSubstance P7VDM-MRGPRX2-Substance P-Gi1/&β;1/&γ;2
5.26Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/&β;1/&γ;2
5.26Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/&β;1/&γ;2
5.00Single3UZAGTPL92363UZA-A2A-GTPL9236
5.00Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
5.00Single7S8O(R)-Zinc-35737S8O-MRGPRX2-(R)-Zinc-3573-Gi1/&β;1/&γ;2
5.00Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
5.00Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
5.00Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/&β;1/&γ;2
5.00Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/&β;1/&γ;2
5.00Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
5.00Consensusadgrg3_onOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
4.76Single3AYMAll-trans-retinal3AYM-Rhodopsin-All-trans-retinal
4.76Single4O9RCyclopamine4O9R-SMO-Cyclopamine
4.76Single7S8N(R)-Zinc-35737S8N-MRGPRX2-(R)-Zinc-3573-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.76Single7UL2SR486927UL2-NTS1-SR48692-Na
4.76Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
4.76Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
4.76Single8F2APramlintide analogue san3858F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
4.76Consensusnts1_off_alloOrthosteric Ligand7UL2-NTS1-SR48692-Na
4.55Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
4.55Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
4.55Single4QINSAG1.54QIN-SMO-SAG1.5
4.55Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
4.55Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
4.55Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
4.55Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
4.55Consensussmo_on_alloOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
4.35Single6FFIMMPEP6FFI-mGlu5-MMPEP
4.35Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
4.35Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
4.35Single7VV6C48/807VV6-MRGPRX2-C48/80
4.35Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
4.35Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.35Single8IYXYL-3658IYX-GPR34-YL-365
4.35Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
4.35Consensusgi_class-fOrthosteric Ligandgi_frizzled
4.35Consensusgi_frizzledOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
4.35Consensuslh_on_alloOther Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
4.26Single8F0JPramlintide analogue san458F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2
4.17Single6FFHFenobam6FFH-mGlu5-Fenobam
4.17Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
4.00Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
3.85Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
3.85Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
3.70Single7SHEPI; PE7SHE-GPR158-PI; PE
3.70Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
3.70Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
3.57Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
3.23Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
2.63Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
2.63Single7TYLAmylin7TYL-CT-Amylin-Gs/&β;1/&γ;2
2.50Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
2.50Single8F0KPramlintide analogue san3858F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.17Single8F2BPramlintide analogue san458F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3

Consensus Members
Id Members
cb1_on 8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
6KPG-CB1-AM841-Gi1/&β;1/&γ;2
6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
cb2_on 8GUS-CB2-HU-308-Gi1/&β;1/&γ;2
8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2
8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2
8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2
6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2
6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
Net Summary
Imin 2.8875
Number of Linked Nodes 265
Number of Links 297
Number of Hubs 36
Number of Links mediated by Hubs 159
Number of Communities 6
Number of Nodes involved in Communities 49
Number of Links involved in Communities 74
Path Summary
Number Of Nodes in MetaPath 54
Number Of Links MetaPath 53
Number of Shortest Paths 46109
Length Of Smallest Path 3
Average Path Length 13.4814
Length of Longest Path 31
Minimum Path Strength 0.265417
Average Path Strength 5.39166
Maximum Path Strength 21.8575
Minimum Path Correlation 0.7
Average Path Correlation 0.922372
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 3.7037
Average % Of Corr. Nodes 46.559
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 43.3337
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following differences:
Id1st Network2nd Network
cannabinoid_off_oncannabinoid_offcannabinoid_on
This network is also present in following consensuses:
IdComponents
lipid_oncannabinoid_on
ffa_on
gpr119_on
leuko_on
lpl_on
prostanoid_on



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Download cannabinoid_on.zip



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