Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
1Lig 12.81272610
2NT.Y68 9.2175414
31x26 4.956513
41x31 5.02403
51x39 3.806536
61x50 4.4525409
72x38 3.2925407
82x42 3.6408
92x50 5.36549
102x53 4.96407
11E1x50 8.154568
12E1x52 4.63407
133x16 5.185403
143x26 3407
153x28 5.85406
163x30 3.985406
173x51 5.752588
184x38 3.265457
194x50 6.52409
205x32 2.74405
215x46 7.17715
225x57 4.295407
235x58 5.55167679
245x61 2.988508
256x44 4.394509
266x48 6.03618
276x55 11.3125415
28E3.M336 4.645411
297x23 8.0625425
307x35 12.1725434
318x50 3.146509
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
12x64 7x35 19.630322.27NoYes054
21x27 2x64 20.94171.43NoNo025
31x27 7x31 22.26431.43NoNo024
47x31 Lig 22.942613.98NoYes140
52x53 7x42 14.69032.5YesNo077
62x53 6x48 20.11646.75YesYes078
76x48 Lig 41.74773.75YesYes180
82x57 7x42 11.84155.9NoNo077
91x50 2x50 47.84084.04YesYes099
102x46 2x50 50.83654.07NoYes499
112x46 3x42 53.1545.49NoNo098
122x45 3x42 56.20627.45NoNo098
132x45 4x46 88.31114.64NoNo098
144x46 4x50 89.80334.7NoYes089
154x50 4x54 92.06425.01YesNo094
163x30 4x54 92.88945.36YesNo064
173x30 3x31 94.04253.65YesNo065
182x551 3x31 94.40434.28NoNo065
192x551 3x28 95.09385.02NoYes066
202x59 3x28 1003.77NoYes076
212x59 Lig 99.8872.94NoYes170
221x50 2x47 44.51733.13YesNo099
231x60 I1x50 11.705914.02NoNo057
248x50 I1x50 13.00594.98YesNo097
251x53 8x50 38.7353.65NoYes099
261x53 2x47 40.91113.15NoNo099
272x38 I1x52 11.70591.7YesNo078
282x40 I1x52 15.911110.9NoNo088
292x40 8x50 17.21122.42NoYes089
302x42 2x45 52.80923YesNo089
312x42 3x46 42.06995.54YesNo089
323x16 E1x50 26.62794.47YesYes038
333x16 3x17 30.46013.78YesNo033
343x17 3x18 31.71498.93NoNo037
353x18 E1x52 32.95843.62NoYes077
363x24 E1x52 36.62116.09NoYes067
373x24 3x28 37.819410.96NoYes066
383x25 E1x50 19.93563.92NoYes698
393x25 3x26 18.65821.62NoYes097
403x26 4x63 11.70595.82YesNo074
415x43 5x46 14.119411.72NoYes155
425x43 Lig 18.19474.56NoYes150
436x44 6x48 22.73346.01YesYes098
443x51 5x61 14.52073.59YesYes088
455x58 5x61 30.43752.39YesYes098
463x50 5x58 39.88245.14NoYes099
473x46 3x50 40.97333.64NoNo099
482x42 3x49 11.5082.71YesNo088
493x49 3x52 10.17417.15NoNo085
504x63 5x32 10.28152.92NoYes045
515x46 6x52 12.86468.71YesNo157
525x61 5x65 11.68322.89YesNo088
535x65 6x30 10.25329.93NoNo087
546x44 7x45 13.07947.25YesNo099
55E3.M336 Lig 14.26076.87YesYes110
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
E2x51Lig81NoYes4010
5x36Lig11.551NoYes4010
6x59Lig4.591NoYes5010
E2.V227Lig2.981NoYes1010
E3.M336Lig6.871YesYes1010
LigNT.Y685.821YesYes0401
E2.Y231Lig25.081NoYes1010
1x26Lig3.941YesYes3010
7x27Lig6.31NoYes3010
E2.F229Lig5.241NoYes3010
E2.T238Lig12.541NoYes3010
1x24Lig5.641NoYes2010
6x58Lig3.721NoYes4010
7x31Lig13.981NoYes4010
7x34Lig15.971NoYes4010
E1.G144Lig3.30NoYes4010
6x55Lig14.961YesYes5010
2x60Lig9.911NoYes6010
7x38Lig5.891NoYes6010
2x59Lig2.941NoYes7010
3x32Lig4.121NoYes7010
3x33Lig9.281NoYes4010
5x43Lig4.561NoYes5010
6x48Lig3.751YesYes8010
1x24NT.Y687.891NoYes2411
E2.Y231NT.Y6813.91NoYes1411
E2.R232NT.Y689.260NoYes2421
1x241x258.51NoNo2312
1x267x244.851YesNo3812
1x267x275.641YesNo3311
1x267x286.121YesNo3312
1x267x314.231YesNo3411
2x532x568.050YesNo7722
2x536x486.750YesYes7821
2x562x608.080NoNo7621
2x563x3219.580NoNo7721
2x593x283.771NoYes7612
2x607x385.661NoNo6611
3x334x6112.151NoNo4512
3x365x4612.621NoYes7522
3x366x484.91NoYes7821
E2.P228E2.V2273.530NoNo1121
E2.F229E2.H2366.791NoNo3212
E2.F229E2.T2385.191NoNo3311
E2.T238E2x516.021NoNo3411
5x36E2x523.991NoNo4512
5x406x558.340NoYes5521
5x406x596.910NoNo5521
5x425x434.561NoNo4521
5x425x464.011NoYes4522
5x435x4611.721NoYes5512
5x465x464.131YesYes5522
6x446x486.010YesYes9821
6x486x515.691YesNo8612
6x487x419.081YesNo8712
6x546x583.060NoNo5421
6x547x348.830NoNo5421
6x556x5813.611YesNo5411
6x557x348.341YesNo5411
6x62E3.M3364.791NoYes3121
6x62E3.N3394.651NoNo3222
6x627x273.521NoNo3321
E3.M336E3.N3394.211YesNo1212
7x247x283.441NoNo8322
E3.E335E3.M3362.710NoYes1121
5x365x372.611NoNo4312
E2.Y231NT.N672.331NoNo1312
5x416x592.320NoNo4521
1x277x311.430NoNo2421

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
66.67Consensusgs_endothelinOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
62.96Consensusendothelin_onOrthosteric Ligandetb_on eta_on
56.67Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
56.00Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
55.17Single6IGLIRL16206IGL-ETB-IRL1620
55.17Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
55.17Single8IY6Endothelin-18IY6-ETB-Endothelin-1
55.17Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
54.84Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
53.33Single5GLHEndothelin-15GLH-ETB-Endothelin-1
52.17Single7Y66BM2137Y66-C5a1-BM213-Gi1/&β;1/&γ;2
52.00Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
51.72Consensusetb_onOrthosteric Ligand8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
50.00Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
50.00Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
50.00Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
48.48Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
48.48Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
48.48Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
48.39Single6IGKEndothelin-36IGK-ETB-Endothelin-3
48.39Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
48.28Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
48.28Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
48.00Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
48.00Consensusmotilin_onOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
46.88Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
46.67Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
46.43Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
46.15Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
46.15Consensussst2_onOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
45.83Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
45.16Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
45.16Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
45.16Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
44.83Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
44.83Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
44.83Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
44.44Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
44.12Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
44.00Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
44.00Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
44.00Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
42.86Single3OE0CVX153OE0-CXCR4-CVX15
42.86Consensusangiotensin_onOrthosteric Ligandat1_on
42.86Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
42.86Consensuscx3cr1_onOrthosteric Ligand7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
42.86Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
42.86Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
42.86Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
42.31Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
42.31Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
42.31Consensuslpl_offOrthosteric Ligands1p_off lpa_off
42.31Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
42.31Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
41.94Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
41.94Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
41.67Single6OS1TRV0266OS1-AT1-TRV026
41.67Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2
41.67Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
41.67Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
41.38Single6JODAngiotensin II6JOD-AT2-Angiotensin II
41.38Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
41.38Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
41.38Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
41.38Consensusnmur2_onOrthosteric Ligand7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
41.18Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
40.91Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
40.91Consensuscxcr_onOrthosteric Ligandcxcr1_on cxcr2_on
40.74Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
40.74Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
40.74Consensusfpr-alx_onOrthosteric Ligandfpr1-alx_on fpr2-alx_on
40.74Consensusmop_offOrthosteric Ligand7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
40.74Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
40.62Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
40.00Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/&β;1/&γ;2
40.00Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
40.00Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
40.00Single7KH0Acyclovir triphosphate7KH0-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
40.00Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
40.00Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
40.00Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
39.29Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
39.29Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
39.29Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
39.29Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
39.29Consensuscx3cr_onOrthosteric Ligandcx3cr1_on
39.29Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
38.71Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
38.71Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
38.71Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
38.71Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
38.71Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
38.71Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
38.46Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
38.46Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
38.46Consensusgs_orexinOrthosteric Ligand7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
38.46Consensusorexin_onOrthosteric Ligandox2_on
38.24Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
37.93Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
37.93Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
37.93Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
37.93Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
37.93Consensusgi_formylpeptideOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
37.93Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
37.50Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
37.50Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
37.50Single8QOTNanobody E8QOT-μ-Nanobody E
37.04Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
37.04Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
37.04Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
37.04Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
37.04Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2 8I95-C3aB-EP54-Go/&β;1/&γ;2
37.04Consensusfpr2-alx_onOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
37.04Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
37.04Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
36.67Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
36.67Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
36.67Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
36.67Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
36.67Consensusgi_somatostatinOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
36.36Single7VGXNeuropeptide Y7VGX-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
36.00Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
36.00Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
36.00Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
36.00Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1
36.00Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/&β;1/&γ;1
36.00Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
36.00Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
36.00Consensuscck_onOrthosteric Ligandccka_on cckb_on
36.00Consensuschemerin_onOrthosteric Ligandcml1_on
36.00Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
36.00Consensuscml1_onOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
36.00Consensuslpa_offOrthosteric Ligandlpa1_off
35.71Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
35.71Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/&β;1/&γ;1
35.71Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
35.71Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
35.71Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
35.71Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
35.71Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
35.48Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
35.48Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
35.48Consensusgs_bradykininOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
35.48Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
34.78Single7XOVSR1461317XOV-CCKA-SR146131-Gs/&β;1/&γ;2
34.62Single4GRVNeurotensin 8-134GRV-NTS1-Neurotensin 8-13
34.62Single4XEENeurotensin4XEE-NTS1-Neurotensin
34.62Single4XESNeurotensin4XES-NTS1-Neurotensin
34.62Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
34.62Single6OS2TRV0266OS2-AT1-TRV026
34.62Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
34.62Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
34.62Single7Y24Octreotide7Y24-SST2-Octreotide-Go/&β;1/&γ;2
34.62Single8IBUErythromycin A8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
34.62Single8J6DEP1418J6D-C3aB-EP141-Go/&β;1/&γ;2
34.62Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
34.62Consensuschemokine_offOrthosteric Ligandcxcr_off
34.62Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II
34.62Consensuscxcr_offOrthosteric Ligandcxcr4_off
34.62Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
34.62Consensusdp_offOrthosteric Liganddp2_off
34.48Single3QAKUK-4320973QAK-A2A-UK-432097
34.48Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
34.48Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
34.48Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
34.48Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
34.48Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
34.38Single4XT3Fractalkine4XT3-US28-Fractalkine
34.38Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
34.38Single7SK3CXCL127SK3-ACKR3-CXCL12
34.38Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
34.38Consensusgi_neuromedinOrthosteric Ligand7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
33.33Single4BUONeurotensin4BUO-NTS1-Neurotensin
33.33Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
33.33Single5WF5UK-4320975WF5-A2A-UK-432097
33.33Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
33.33Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
33.33Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
33.33Single6PT2KGCHM076PT2-δ-KGCHM07
33.33Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
33.33Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Single7EZCUKA7EZC-A2A-UKA
33.33Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
33.33Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
33.33Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
33.33Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
33.33Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
33.33Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
33.33Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
33.33Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
33.33Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
33.33Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
33.33Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
33.33Consensusgi_chemerinOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
33.33Consensusgi_neurotensinOrthosteric Ligand7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
33.33Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
32.35Single8FEGPRD_0025178FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
32.26Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
32.26Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
32.26Single7C61Ergotamine7C61-5-HT1B-Ergotamine
32.26Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
32.26Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
32.26Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
32.26Consensusnmur_onOrthosteric Ligandnmur1_on nmur2_on
32.26Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
32.14Single4UG2CGS216804UG2-A2A-CGS21680
32.14Single5WF6UK-4320975WF6-A2A-UK-432097
32.14Single6KNMJN241-96KNM-Apelin-JN241-9
32.14Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
32.14Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
32.14Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
32.14Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
32.14Single7XN9L-054,5227XN9-SST2-L-054,522
32.14Single7XY6PubChem 117178317XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
32.14Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
32.14Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
32.14Consensuslpl_onOrthosteric Ligands1p_on lpa_on
32.00Single5C1MBU725C1M-μ-BU72
32.00Single5N2RPubChem 92460631; psb365N2R-A2A-PubChem 92460631; psb36-Na
32.00Single5N2SPSB365N2S-A1-PSB36
32.00Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
32.00Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
32.00Single8FN1Neurotensin/neuromedin N8FN1-NTS1-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
32.00Single8JPCNeurotensin 8-138JPC-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
31.82Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
31.82Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
31.82Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
31.43Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
31.25Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
31.25Consensusbk1_onOrthosteric Ligand7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.25Consensusgs_neuromedinOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.03Single4IARErgotamine4IAR-5-HT1B-Ergotamine
31.03Single4XT1Fractalkine4XT1-US28-Fractalkine
31.03Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
31.03Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.03Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
31.03Single8G59TUG-8918G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
31.03Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
31.03Consensussst_onOrthosteric Ligandsst2_on sst4_on
30.77Single4BV0Neurotensin4BV0-NTS1-Neurotensin
30.77Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
30.77Single4RWADIPP-NH24RWA-δ-DIPP-NH2
30.77Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
30.77Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
30.77Single7F1TMIP-1a7F1T-CCR5-MIP-1a
30.77Single7FEEPubMed 1048957FEE-CB1-PubMed 104895-ZCZ011
30.77Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
30.77Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
30.77Single8E0GBU728E0G-μ-BU72
30.77Single8FMZNeurotensin/neuromedin N8FMZ-NTS1-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
30.77Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
30.77Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.77Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
30.77Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
30.77Consensusffa4_onOrthosteric Ligand8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
30.77Consensusgi_ffaOrthosteric Ligand8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
30.77Consensusgs_compl-peptideOrthosteric Ligand8I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.77Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
30.77Consensuslpa_onOrthosteric Ligandlpa1_on
30.56Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
30.43Single4BWBNeurotensin4BWB-NTS1-Neurotensin
30.43Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
30.43Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
30.43Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
30.43Single7W0OElabela7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
30.43Single8GNGIstradefylline8GNG-A2A-Istradefylline
30.43Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
30.43Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
30.43Consensusm2_on_alloOther Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
30.43Consensusp2y_offOrthosteric Ligandp2y1_off p2y12_off
30.30Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
30.30Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
30.30Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
30.00Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
30.00Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
30.00Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
30.00Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
30.00Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
30.00Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
29.63Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
29.63Single6KQIPubMed 1048956KQI-CB1-PubMed 104895-ORG27569
29.63Single6MXTSalmeterol6MXT-β2-Salmeterol
29.63Single6YVRNTS8-136YVR-NTS1-NTS8-13
29.63Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/&β;1/γ1
29.63Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
29.63Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
29.63Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
29.63Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
29.63Single7YITNalfurafine7YIT-κ-Nalfurafine
29.63Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2
29.63Single8I95EP548I95-C3aB-EP54-Go/&β;1/&γ;2
29.63Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2
29.63Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2
29.63Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
29.63Single8JPBNeurotensin 8-138JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
29.63Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
29.63Consensuscb1_off_alloOrthosteric Ligand6KQI-CB1-PubMed 104895-ORG27569
29.63Consensusleuko_offOrthosteric Ligandblt_off cyslt_off
29.63Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
29.63Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
29.63Consensusnts1_onOrthosteric Ligand6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
29.63Consensusnts_onOrthosteric Ligandnts1_on
29.63Consensusopioid_offOrthosteric Ligandkop_off mop_off nop_off dop_off
29.63Consensuspeptide_offOrthosteric Ligandopioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
29.63Consensustsh_on_alloOther Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
29.41Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
29.41Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
29.41Consensusgo_class-b1Orthosteric Ligandgo_crf
29.41Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
29.17Single4MBSMaraviroc4MBS-CCR5-Maraviroc
29.17Single5K2BZM2413855K2B-A2A-ZM241385-Na
29.17Single6MH8ZM2413856MH8-A2A-ZM241385
29.17Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
29.17Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
29.17Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.17Consensusgnrh_offOrthosteric Ligandgnrh1_off
29.03Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1
29.03Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
29.03Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
28.95Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
28.57Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
28.57Single6DDFDamgo6DDF-μ-Damgo-Gi1/&β;1/&γ;2
28.57Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
28.57Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
28.57Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
28.57Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
28.57Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/&β;1/&γ;2
28.57Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
28.57Single7XJISolabegron7XJI-β3-Solabegron-Gs/&β;1/&γ;2
28.57Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/&β;1/&γ;2
28.57Single8ID8TUG-8918ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
28.57Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
28.57Single8WRZ8D08WRZ-CB1-8D0-Arrestin1
28.57Consensusc5a1_off_ortoalloOrthosteric Ligand6C1Q-C5a1-PMX53-NDT9513727 6C1R-C5a1-PMX53-Avacopan; Na
28.57Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
28.57Consensusgs_galaninOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
28.57Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
28.12Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
28.12Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
28.12Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
28.00Single3EMLZM2413853EML-A2A-ZM241385
28.00Single4EJ4Naltrindole4EJ4-δ-Naltrindole
28.00Single5K2AZM2413855K2A-A2A-ZM241385-Na
28.00Single5VRAZM2413855VRA-A2A-ZM241385-Na
28.00Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
28.00Single6S0LZM2413856S0L-A2A-ZM241385
28.00Single7CRHSKF839597CRH-D1-SKF83959-Gs/&β;1/&γ;2
28.00Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
28.00Single7V3ZPubMed 1048957V3Z-CB1-PubMed 104895
28.00Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
28.00Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
28.00Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
28.00Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
28.00Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
28.00Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
28.00Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
28.00Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
27.78Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
27.78Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
27.78Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
27.59Single3NY9PubChem 9131033NY9-β2-PubChem 913103
27.59Single5ZTYAM102575ZTY-CB2-AM10257
27.59Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
27.59Single6PT3DPI-2876PT3-δ-DPI-287
27.59Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
27.59Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.59Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
27.59Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
27.59Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
27.59Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
27.59Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
27.59Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
27.59Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
27.59Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.27Single4XNWMRS25004XNW-P2Y1-MRS2500
27.27Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
27.27Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
27.27Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
27.27Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
27.27Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
27.27Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
26.92Single5IUAQ274563485IUA-A2A-Q27456348-Na
26.92Single5NM2ZM2413855NM2-A2A-ZM241385-Na
26.92Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
26.92Single6D26Fevipiprant6D26-DP2-Fevipiprant
26.92Single6DDEDamgo6DDE-μ-Damgo-Gi1/&β;1/&γ;2
26.92Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
26.92Single6LPLZM2413856LPL-A2A-ZM241385-Na
26.92Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
26.92Single6S0QZM2413856S0Q-A2A-ZM241385
26.92Single6WQAZM2413856WQA-A2A-ZM241385-Na
26.92Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
26.92Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
26.92Single7CFNINT-7777CFN-GPBA-INT-777-Gs/&β;1/&γ;2
26.92Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
26.92Single7RM5ZM2413857RM5-A2A-ZM241385-Na
26.92Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
26.92Single8DZQmomSalB8DZQ-κ-momSalB-Go/&β;1/&γ;2
26.92Single8FYNZM2413858FYN-A2A-ZM241385-Na
26.92Single8GNEKW-63568GNE-A2A-KW-6356-Na
26.92Single8ID9Eicosapentaenoic acid8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
26.92Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
26.92Consensuscb2_onOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
26.92Consensusgo_opioidOrthosteric Ligand8DZQ-κ-momSalB-Go/&β;1/&γ;2
26.67Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
26.67Single7F8XNN90567F8X-CCKA-NN9056
26.67Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
26.67Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
26.67Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
26.67Single8GHVPubChem 1459649038GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
26.67Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
26.47Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
26.47Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
26.47Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.47Consensusbb1_onOrthosteric Ligand8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.09Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
26.09Single8GH1Epinephrine8GH1-β2-Epinephrine
26.09Consensusm4_on_alloOther Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
25.93Single2YDVNECA2YDV-A2A-NECA
25.93Single4DJHJDTic4DJH-κ-JDTic
25.93Single4UHRCGS216804UHR-A2A-CGS21680
25.93Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
25.93Single5G53NECA5G53-A2A-NECA-Gs
25.93Single5X93K-87945X93-ETB-K-8794
25.93Single5XRAAM115425XRA-CB1-AM11542
25.93Single6J21Aprepitant6J21-NK1-Aprepitant
25.93Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
25.93Single7EW7PubChem 40774607EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
25.93Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
25.93Single7JVPSKF839597JVP-D1-SKF83959-Gs/&β;1/&γ;2
25.93Single7PX4PSB-21137PX4-A2A-PSB-2113
25.93Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
25.93Single7WV9PubMed 1048957WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
25.93Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
25.93Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.93Single7XTQR3997XTQ-GPBA-R399-Gs/&β;1/&γ;2
25.93Single8DZPmomSalB8DZP-κ-momSalB-Gi1/&β;1/&γ;2
25.93Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
25.93Consensus5ht1b_onOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
25.93Consensusa2_onOrthosteric Liganda2a_on a2b_on
25.93Consensusadenosine_offOrthosteric Liganda1_off a2_off
25.93Consensuscyslt1_off_ortoalloOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
25.93Consensusdopamine_offOrthosteric Ligandd3_off d2_off d4_off
25.93Consensusgi_dopamineOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
25.93Consensusgi_muscarinicOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
25.93Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
25.93Consensusnpy_offOrthosteric Ligandnpy2_off npy1_off
25.93Consensusnts1_on_alloOrthosteric Ligand8JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
25.93Consensusrelaxin_onOrthosteric Ligandrxfp4_on
25.93Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
25.81Single6HLOAprepitant6HLO-NK1-Aprepitant
25.81Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
25.81Single7SK5CXCL127SK5-ACKR3-CXCL12
25.81Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
25.81Consensusalpha1_offOrthosteric Ligandalpha1a_off alpha1b_off
25.71Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
25.71Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single2X72All-trans-retinal2X72-Rhodopsin-All-trans-retinal-Gt(CT)
25.00Single3ODUIT1t3ODU-CXCR4-IT1t
25.00Single4AMIBucindolol4AMI-β1-Bucindolol
25.00Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
25.00Single6A93Risperidone6A93-5-HT2A-Risperidone
25.00Single6AKXA4R6AKX-CCR5-A4R
25.00Single6AKYMaraviroc6AKY-CCR5-Maraviroc
25.00Single6B73PubChem 1319551386B73-κ-PubChem 131955138
25.00Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
25.00Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
25.00Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
25.00Single6NWEOctyl Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
25.00Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
25.00Single7BR3Elagolix7BR3-GnRH1-Elagolix
25.00Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/&β;1/&γ;2
25.00Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/&β;1/&γ;2
25.00Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
25.00Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
25.00Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
25.00Single7F8ULintitript7F8U-CCKA-Lintitript
25.00Single7F8YDevazepide7F8Y-CCKA-Devazepide
25.00Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
25.00Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
25.00Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
25.00Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
25.00Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
25.00Single7WCNAR2314537WCN-GPR119-AR231453-Gs/&β;1/&γ;2
25.00Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
25.00Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
25.00Single7XNACYN1548067XNA-SST2-CYN154806
25.00Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;2
25.00Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
25.00Single8EFOPZM218EFO-μ-PZM21-Gi1/&β;1/&γ;2
25.00Single8FN0Neurotensin/neuromedin N8FN0-NTS1-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
25.00Single8GGFEpinephrine8GGF-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.00Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
25.00Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single8JJLOlodaterol8JJL-β2-Olodaterol
25.00Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/&β;1/&γ;2
25.00Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
25.00Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
25.00Consensuscannabinoid_onOrthosteric Ligandcb1_on cb2_on
25.00Consensuscb1_onOrthosteric Ligand8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
25.00Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
25.00Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
25.00Consensusgi_cannabinoidOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
25.00Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
25.00Consensusgo_5htOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
25.00Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
25.00Consensusgs_bileacidOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
25.00Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
25.00Consensusgs_steroidOrthosteric Ligandgs_bileacid
25.00Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
25.00Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
25.00Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
24.32Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
24.24Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
24.24Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
24.24Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
24.24Single8IHFMK68928IHF-HCA2-MK6892-Gi1/&β;1/&γ;2
24.24Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
24.24Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
24.14Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
24.14Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
24.14Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
24.14Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
24.14Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
24.14Single6IBLArformoterol6IBL-β1-Arformoterol
24.14Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
24.14Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2
24.14Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
24.14Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
24.14Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
24.14Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
24.14Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
24.14Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
24.14Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
24.14Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
24.14Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
24.14Consensusbeta1_off_alloOrthosteric Ligand4BVN-β1-Cyanopindolol-Na
24.14Consensusbileacid_onOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
24.14Consensuscckb_onOrthosteric Ligand7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
24.14Consensuscyslt2_offOrthosteric Ligand6RZ6-CysLT2-ONO-2570366 6RZ9-CysLT2-ONO-2770372 6RZ8-CysLT2-ONO-2080365
24.14Consensuscyslt_offOrthosteric Ligandcyslt2_off
24.14Consensusendothelin_offOrthosteric Ligandetb_off
24.14Consensusetb_offOrthosteric Ligand5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500 5X93-ETB-K-8794
24.14Consensusffa4_on_alloOrthosteric Ligand8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
24.14Consensusot_onOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
24.14Consensussteroid_onOrthosteric Ligandbileacid_on
24.00Single4DKLBeta-funaltrexamine4DKL-μ-Beta-funaltrexamine
24.00Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
24.00Single5IU7Q274563465IU7-A2A-Q27456346-Na
24.00Single5JTBZM2413855JTB-A2A-ZM241385
24.00Single5NLXZM2413855NLX-A2A-ZM241385-Na
24.00Single5TE3Octyl Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
24.00Single5UVIZM2413855UVI-A2A-ZM241385
24.00Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
24.00Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
24.00Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
24.00Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
24.00Single7AROLUF58337ARO-A2A-LUF5833-Na
24.00Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
24.00Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
24.00Single7T32ZM2413857T32-A2A-ZM241385
24.00Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
24.00Single7VV6C48/807VV6-MRGPRX2-C48/80
24.00Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
24.00Single7XJJGalanin7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
24.00Single8GURPubChem 1048958GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2
24.00Single8K4NVF08K4N-GPR34-VF0-Gi1/&β;1/&γ;2
24.00Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
24.00Single8UO2Epinephrine8UO2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
24.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
24.00Consensusdop_off_alloOrthosteric Ligand4N6H-δ-Naltrindole-Na
24.00Consensusffa2_onOrthosteric Ligand8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
24.00Consensusgo_galaninOrthosteric Ligand7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
24.00Consensush3_on_alloOrthosteric Ligand7F61-H3-PF-03654746-Cholesterol
24.00Consensuslh_on_alloOther Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
24.00Consensusm1_off_alloOther Ligand6WJC-M1-Atropine-Muscarinic toxin 7
24.00Consensusox2_offOrthosteric Ligand6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant
23.81Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
23.68Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
23.53Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
23.53Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
23.53Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
23.53Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
23.53Consensusgs_melanocortinOrthosteric Ligand7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2
23.53Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
23.33Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
23.33Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
23.33Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.33Single7SK9CCX6627SK9-ACKR3-CCX662
23.33Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
23.33Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.33Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
23.33Single8SAI1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
23.33Single8X5YAstemizole8X5Y-H1-Astemizole
23.33Consensusgo_vasopressinOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
23.33Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
23.08Single2Y02Carmoterol2Y02-β1-Carmoterol
23.08Single3NY8ICI 118-5513NY8-β2-ICI 118-551
23.08Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
23.08Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
23.08Single4EIYZM2413854EIY-A2A-ZM241385-Na
23.08Single4GBR(S)-Carazolol4GBR-β2-(S)-Carazolol
23.08Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
23.08Single4QIMPubChem 249053754QIM-SMO-PubChem 24905375
23.08Single5IU8Q274563475IU8-A2A-Q27456347-Na
23.08Single5OLGZM2413855OLG-A2A-ZM241385-Na
23.08Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
23.08Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
23.08Single5T04Neurotensin5T04-NTS1-Neurotensin
23.08Single6D27CAY104716D27-DP2-CAY10471
23.08Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2
23.08Single6LPJZM2413856LPJ-A2A-ZM241385-Na
23.08Single6LPKZM2413856LPK-A2A-ZM241385-Na
23.08Single6PS0(S)-Carazolol6PS0-β2-(S)-Carazolol
23.08Single6PS2(S)-Alprenolol6PS2-β2-(S)-Alprenolol
23.08Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
23.08Single7CFMP3957CFM-GPBA-P395-Gs/&β;1/&γ;2
23.08Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
23.08Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
23.08Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
23.08Single7LJCPubChem 867641037LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
23.08Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
23.08Single7PYRPSB-21157PYR-A2A-PSB-2115
23.08Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
23.08Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
23.08Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
23.08Single8CU6LJ-45178CU6-A2A-LJ-4517
23.08Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
23.08Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
23.08Single8EFQDamgo8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
23.08Single8GEHEpinephrine8GEH-β2-Epinephrine-Gs/&β;1/&γ;2
23.08Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
23.08Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
23.08Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
23.08Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
23.08Consensusa2_offOrthosteric Liganda2a_off
23.08Consensusa2a_offOrthosteric Ligand8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 5UIG-A2A-J3.651.884G 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-PubChem 168451710 5K2D-A2A-ZM241385
23.08Consensusadenosine_onOrthosteric Liganda1_on a2_on
23.08Consensusalpha2_onOrthosteric Ligandalpha2a_on alpha2b_on
23.08Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
23.08Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
23.08Consensuscb1_on_alloOrthosteric Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
23.08Consensuscck_offOrthosteric Ligandccka_off
23.08Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
23.08Consensusffa_onOrthosteric Ligandffa4_on ffa1_on ffa2_on ffa3_on
23.08Consensusfsh_on_alloOther Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
23.08Consensusgi_hcaOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
23.08Consensusgi_hcarOrthosteric Ligandgi_hca
23.08Consensushca2_onOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
23.08Consensusnucleotide_onOrthosteric Ligandadenosine_on
23.08Consensusp2y12_offOrthosteric Ligand4NTJ-P2Y12-AZD1283 7PP1-P2Y12-Selatogrel
23.08Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
23.08Consensussmo_offOrthosteric Ligand5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
23.08Consensustar_onOrthosteric Ligandta1_on
22.86Single6FJ3PTH6FJ3-PTH1-PTH
22.86Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
22.86Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
22.86Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
22.86Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
22.73Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/&β;1/&γ;2
22.58Single4AMJ(S)-Carvedilol4AMJ-β1-(S)-Carvedilol
22.58Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
22.58Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
22.58Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
22.58Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.58Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
22.58Single8J6RMK68928J6R-HCA2-MK6892-Gi1/&β;1/&γ;2
22.58Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
22.58Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
22.58Consensusnmur1_onOrthosteric Ligand7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.50Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
22.50Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
22.50Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
22.22Single2RH1(S)-Carazolol2RH1-β2-(S)-Carazolol
22.22Single2YCW(S)-Carazolol2YCW-β1-(S)-Carazolol
22.22Single5D6L(S)-Carazolol5D6L-β2-(S)-Carazolol
22.22Single5X7D(S)-Carazolol5X7D-β2-(S)-Carazolol-PubChem 129318963
22.22Single5XPRBosentan5XPR-ETB-Bosentan
22.22Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
22.22Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
22.22Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
22.22Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
22.22Single7C4SS1P7C4S-S1P3-S1P
22.22Single7CKXA776367CKX-D1-A77636-Gs/&β;1/&γ;2
22.22Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
22.22Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
22.22Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
22.22Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
22.22Single7SBFPZM217SBF-μ-PZM21-Gi1/&β;1/&γ;2
22.22Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
22.22Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
22.22Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
22.22Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
22.22Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
22.22Single7XKAEpinephrine7XKA-β2-Epinephrine
22.22Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.22Single7Y27Somatostatin-147Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.22Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
22.22Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
22.22Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
22.22Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
22.22Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
22.22Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
22.22Single8UNYEpinephrine8UNY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.22Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
22.22Consensusa1_on_alloOrthosteric Ligand7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
22.22Consensusadrenergic_offOrthosteric Ligandbeta_off alpha_off
22.22Consensusalpha2a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
22.22Consensusamine_offOrthosteric Ligandadrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
22.22Consensusbeta2_offOrthosteric Ligand6PS2-β2-(S)-Alprenolol 6PS3-β2-(S)-Carvedilol 6PS5-β2-(S)-Propranolol 6PS6-β2-Timolol 2RH1-β2-(S)-Carazolol 6PS4-β2-ICI 118-551 3NY9-β2-PubChem 913103
22.22Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
22.22Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRR-D1-Rotigotine-Gs/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
22.22Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
22.22Consensusgo_amineOrthosteric Ligandgo_adrenergic go_muscarinic go_5ht
22.22Consensusgs_sstOrthosteric Ligand7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.22Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
22.22Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
22.22Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
21.95Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
21.95Consensuspth_onOrthosteric Ligandpth1_on pth2_on
21.88Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
21.88Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
21.88Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/&β;1/&γ;2
21.88Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
21.88Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
21.88Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
21.88Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.88Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
21.88Consensussst_offOrthosteric Ligandsst2_off
21.74Single3OE6IT1t3OE6-CXCR4-IT1t
21.74Single5WKTOctyl Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
21.74Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
21.74Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
21.62Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
21.62Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
21.62Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
21.43Single3P0GBI1671073P0G-β2-BI167107
21.43Single3SN6BI1671073SN6-β2-BI167107-Gs/&β;1/&γ;2
21.43Single5D5A(S)-Carazolol5D5A-β2-(S)-Carazolol
21.43Single5D5B(S)-Carazolol5D5B-β2-(S)-Carazolol
21.43Single5V56TC1145V56-SMO-TC114
21.43Single5XR8AM8415XR8-CB1-AM841
21.43Single6NI3BI1671076NI3-β2-BI167107-Gs/&β;1/&γ;2
21.43Single6TQ7SB-3348676TQ7-OX1-SB-334867
21.43Single6WGTLSD6WGT-5-HT2A-LSD
21.43Single7CKYPW04647CKY-D1-PW0464-Gs/&β;1/&γ;2
21.43Single7JV5SKF812977JV5-D1-SKF81297-Gs/&β;1/&γ;2
21.43Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
21.43Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
21.43Single7TUYGSK682753A7TUY-GPR183-GSK682753A
21.43Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
21.43Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2
21.43Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
21.43Single7W6PW967W6P-α2a-W96-Go/&β;1/&γ;2
21.43Single7W7EW587W7E-α2a-W58-Go/&β;1/&γ;2
21.43Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.43Single7XOWGastrin7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
21.43Single7XOXCholecystokinin-87XOX-CCKB-Cholecystokinin-8-Gq/&β;1/&γ;2
21.43Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.43Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/&β;1/&γ;2
21.43Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
21.43Single8G056-OAU8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
21.43Single8GUSHU-3088GUS-CB2-HU-308-Gi1/&β;1/&γ;2
21.43Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2
21.43Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
21.43Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2
21.43Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2
21.43Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/&β;1/&γ;2
21.43Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
21.43Single8JXVClozapine8JXV-H4-Clozapine-Gi1/&β;1/&γ;2
21.43Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.43Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
21.43Consensus5ht_offOrthosteric Ligand5ht2_off 5ht5_off 5ht1_off
21.43Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
21.43Consensusangiotensin_offOrthosteric Ligandat1_off at2_off
21.43Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCZ-β1-Iodocyanopindolol
21.43Consensusgi_amineOrthosteric Ligandgi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
21.43Consensusgo_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
21.43Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A2A-NECA-Gs/&β;1/&γ;1 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
21.43Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2
21.43Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
21.43Consensush1_offOrthosteric Ligand3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole 8X63-H1-Mepyramine 8X64-H1-Desloratadine
21.43Consensushistamine_offOrthosteric Ligandh1_off
21.43Consensusnk1_offOrthosteric Ligand6J20-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
21.43Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
21.43Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
21.21Single6W25SHU91196W25-MC4-SHU9119-Ca
21.21Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
21.05Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
21.05Consensusgs_crfOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
20.93Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
20.93Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
20.83Single3OE9IT1t3OE9-CXCR4-IT1t
20.83Single4O9RCyclopamine4O9R-SMO-Cyclopamine
20.83Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
20.83Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
20.83Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
20.83Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2
20.83Single8EF6Morphine8EF6-μ-Morphine-Gi1/&β;1/&γ;2
20.83Single8GGCEpinephrine8GGC-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
20.83Single8GGEEpinephrine8GGE-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
20.83Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/&β;1/&γ;2
20.83Single8IJANiacin8IJA-HCA2-Niacin-Gi1/&β;1/&γ;2
20.83Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
20.83Consensusclass-t_onOrthosteric Ligandtaste2_on
20.83Consensusgo_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
20.83Consensusgo_proteinOrthosteric Ligandgo_chemokine
20.83Consensusgs_class-tOrthosteric Ligandgs_taste
20.83Consensusgs_tasteOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
20.83Consensustaste2_onOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
20.69Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
20.69Single3D4STimolol Maleate3D4S-β2-Timolol Maleate
20.69Single4PY02MeSATP4PY0-P2Y12-2MeSATP
20.69Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
20.69Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
20.69Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
20.69Single6HLPNetupitant6HLP-NK1-Netupitant
20.69Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
20.69Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
20.69Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
20.69Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
20.69Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
20.69Single7DFPSpiperone7DFP-D2-Spiperone
20.69Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
20.69Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
20.69Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
20.69Single8IJDMK68928IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
20.69Single8JJ8Formoterol8JJ8-β2-Formoterol
20.69Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
20.69Single8WU1KCA8WU1-CB1-KCA-Arrestin1
20.69Consensusat2_offOrthosteric Ligand7JNI-AT2-Olodanrigan
20.69Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
20.69Consensusgi_class-fOther Ligandgi_frizzled
20.69Consensusgi_frizzledOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
20.69Consensusnts1_offOrthosteric Ligand6Z4Q-NTS1-SR142948A 6Z4S-NTS1-SR48692
20.69Consensusnts_offOrthosteric Ligandnts1_off
20.59Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
20.59Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
20.59Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
20.59Single8J6IMK68928J6I-HCA2-MK6892-Gi1/&β;1/&γ;2
20.51Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
20.51Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
20.51Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
20.51Consensusglp_onOrthosteric Ligandglp1_on glp2_on
20.45Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
20.00Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
20.00Single3VG9ZM2413853VG9-A2A-ZM241385-Antibody
20.00Single3VGAZM2413853VGA-A2A-ZM241385-Antibody
20.00Single4QINSAG1.54QIN-SMO-SAG1.5
20.00Single5K2DZM2413855K2D-A2A-ZM241385
20.00Single5WS3EMPA5WS3-OX2-EMPA
20.00Single5ZKQABT-4915ZKQ-PAF-ABT-491
20.00Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
20.00Single6JZHZM2413856JZH-A2A-ZM241385-Na
20.00Single6K1QIRL25006K1Q-ETB-IRL2500
20.00Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
20.00Single6PS7ZM2413856PS7-A2A-ZM241385-Na
20.00Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
20.00Single6WWZCCL206WWZ-CCR6-CCL20-Go/&β;1/&γ;2
20.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
20.00Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
20.00Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
20.00Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
20.00Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
20.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
20.00Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
20.00Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
20.00Single7TUZ7alpha,25-dihydroxycholesterol7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
20.00Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
20.00Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
20.00Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
20.00Single7XK2MK68927XK2-HCA2-MK6892-Gi1/&β;1/&γ;2
20.00Single7XRRLemborexant7XRR-OX2-Lemborexant
20.00Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
20.00Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
20.00Single8E9YPubChem 4466038E9Y-M3-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Single8GAGYVF8GAG-CB1-YVF-Gi1/&β;1/&γ;2
20.00Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/&β;1/&γ;2
20.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
20.00Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Single8UO0Epinephrine8UO0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
20.00Single8UO3Epinephrine8UO3-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
20.00Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
20.00Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
20.00Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
20.00Consensusa2a_off_alloOrthosteric Ligand6ZDR-A2A-HMS1413f12-Na 6GT3-A2A-Imaradenant-Na 8CU7-A2A-LJ-4517-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PubChem 92460631; psb36-Na 5MZJ-A2A-Theophylline-Na 5OLO-A2A-Tozadenant-Na 5OLH-A2A-Vipadenant-Na 5NM4-A2A-ZM241385-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5MZP-A2A-Caffeine-Na 8CIC-A2A-Etrumadenant-Na
20.00Consensusalpha1_onOrthosteric Ligandalpha1a_on
20.00Consensusalpha1a_onOrthosteric Ligand7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Consensusbombesin_onOrthosteric Ligandbb2_on bb1_on
20.00Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
20.00Consensusgi_nucleotideOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
20.00Consensusmelatonin_onOrthosteric Ligandmt1_on mt2_on
20.00Consensusmglu_onOther Ligandmglu2_on mglu4_on
20.00Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Consensusorexin_offOrthosteric Ligandox2_off ox1_off
19.57Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
19.51Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
19.44Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/&β;1/&γ;2
19.44Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
19.44Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
19.44Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
19.35Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
19.35Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
19.35Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
19.35Single8INRAlpha-MSH8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
19.35Single8XZFWN5618XZF-Apelin-WN561-Gi1/&β;1/&γ;2
19.35Consensusclass-d_offOrthosteric Ligandste2_off
19.35Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
19.23Single2YDOAdenosine2YDO-A2A-Adenosine
19.23Single3UZCPubChem 1355666093UZC-A2A-PubChem 135566609
19.23Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
19.23Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
19.23Single4ZJCSB-6740424ZJC-OX1-SB-674042
19.23Single5IU4ZM2413855IU4-A2A-ZM241385-Na
19.23Single5IUBQ274563445IUB-A2A-Q27456344-Na
19.23Single5K2CZM2413855K2C-A2A-ZM241385-Na
19.23Single5NM4ZM2413855NM4-A2A-ZM241385-Na
19.23Single6AQFZM2413856AQF-A2A-ZM241385
19.23Single6DS0Ly2660976DS0-5-HT2B-Ly266097
19.23Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
19.23Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
19.23Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
19.23Single6PS4ICI 118-5516PS4-β2-ICI 118-551
19.23Single6PS5(S)-Propranolol6PS5-β2-(S)-Propranolol
19.23Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
19.23Single6TPGEMPA6TPG-OX2-EMPA
19.23Single6TPNHTL66416TPN-OX2-HTL6641
19.23Single6VI4JDTic6VI4-κ-JDTic
19.23Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
19.23Single6ZINSR486926ZIN-NTS1-SR48692
19.23Single7BB6Acyclovir triphosphate7BB6-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
19.23Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/&β;1/&γ;2
19.23Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
19.23Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
19.23Single7CMVPD1289077CMV-D3-PD128907-Gi1/&β;1/&γ;2
19.23Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
19.23Single7F0TDopamine7F0T-D1-Dopamine-Gs/&β;1/&γ;2
19.23Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/&β;1/&γ;2
19.23Single7JOZVFP7JOZ-D1-VFP-Gs/&β;1/&γ;2
19.23Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
19.23Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
19.23Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
19.23Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
19.23Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
19.23Single8GDZEpinephrine8GDZ-β2-Epinephrine-Gs/&β;1/&γ;2
19.23Single8GEGEpinephrine8GEG-β2-Epinephrine-Gs/&β;1/&γ;2
19.23Single8GGKEpinephrine8GGK-β2-Epinephrine
19.23Single8GGMEpinephrine8GGM-β2-Epinephrine
19.23Single8GGPEpinephrine8GGP-β2-Epinephrine
19.23Single8GGQEpinephrine8GGQ-β2-Epinephrine
19.23Single8GGTEpinephrine8GGT-β2-Epinephrine
19.23Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2
19.23Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
19.23Single8JHNMMF8JHN-HCA2-MMF-Go/&β;1/&γ;2
19.23Single8JIMMMF8JIM-HCA2-MMF-Gi1/&β;1/&γ;2
19.23Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
19.23Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
19.23Single8UNZEpinephrine8UNZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
19.23Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/&β;1/&γ;2
19.23Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
19.23Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6WH4-5-HT2A-Methiothepin 7VOE-5-HT2A-Aripiprazole 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 6A93-5-HT2A-Risperidone
19.23Consensus5ht5_onOrthosteric Ligand5ht5a_on
19.23Consensus5ht5a_onOrthosteric Ligand7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
19.23Consensusalpha2b_onOrthosteric Ligand6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
19.23Consensusd1_on_alloOrthosteric Ligand7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
19.23Consensusd3_onOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
19.23Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
19.23Consensusgi_class-fOrthosteric Ligandgi_frizzled
19.23Consensusgi_frizzledOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
19.23Consensusgi_melatoninOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
19.23Consensusgs_tarOrthosteric Ligand8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
19.23Consensushca_onOrthosteric Ligandhca2_on hca3_on
19.23Consensushcar_onOrthosteric Ligandhca_on
19.23Consensusox1_offOrthosteric Ligand6TOT-OX1-Lemborexant 6TP4-OX1-ACT-462206 6TP6-OX1-Filorexant 6V9S-OX1-GTPL11403 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ7-OX1-SB-334867 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant
19.23Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
19.23Consensuss1p_offOrthosteric Ligands1p1_off
18.92Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
18.92Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
18.92Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
18.75Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
18.75Single7QA8Peptide7QA8-STE2-Peptide
18.75Single7QA8Peptide7QA8-STE2-Peptide
18.75Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
18.75Consensusclass-d_offOrthosteric Ligandste2_off
18.75Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
18.52Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
18.52Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
18.52Single3NYA(S)-Alprenolol3NYA-β2-(S)-Alprenolol
18.52Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
18.52Single4X1HNonyl Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
18.52Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
18.52Single5JQH(S)-Carazolol5JQH-β2-(S)-Carazolol
18.52Single5TGZAM65385TGZ-CB1-AM6538
18.52Single5UENDU1725UEN-A1-DU172
18.52Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
18.52Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
18.52Single6IIVDaltroban6IIV-TP-Daltroban
18.52Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
18.52Single6PRZ(S)-Alprenolol6PRZ-β2-(S)-Alprenolol
18.52Single6PS1Timolol6PS1-β2-Timolol
18.52Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
18.52Single6TOTLemborexant6TOT-OX1-Lemborexant
18.52Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
18.52Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
18.52Single7BU7BI1671077BU7-β1-BI167107
18.52Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
18.52Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
18.52Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
18.52Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
18.52Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
18.52Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
18.52Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
18.52Single7SCGFH2107SCG-μ-FH210-Gi1/&β;1/&γ;2
18.52Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/&β;1/&γ;2
18.52Single7T2GMitragynine pseudoindoxyl7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
18.52Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
18.52Single7UL4Alvimopan7UL4-μ-Alvimopan
18.52Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
18.52Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/&β;1/&γ;2
18.52Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
18.52Single7VKTLTB47VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
18.52Single7WC7Lisuride7WC7-5-HT2A-Lisuride
18.52Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
18.52Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
18.52Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
18.52Single8GE3Epinephrine8GE3-β2-Epinephrine-Gs/&β;1/&γ;2
18.52Single8GEBEpinephrine8GEB-β2-Epinephrine-Gs/&β;1/&γ;2
18.52Single8GEEEpinephrine8GEE-β2-Epinephrine-Gs/&β;1/&γ;2
18.52Single8GFWEpinephrine8GFW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
18.52Single8GFXEpinephrine8GFX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
18.52Single8GFYEpinephrine8GFY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
18.52Single8GFZEpinephrine8GFZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
18.52Single8GG0Epinephrine8GG0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
18.52Single8GG1Epinephrine8GG1-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
18.52Single8GG2Epinephrine8GG2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
18.52Single8GG6Epinephrine8GG6-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
18.52Single8GGBEpinephrine8GGB-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
18.52Single8GGJEpinephrine8GGJ-β2-Epinephrine
18.52Single8GGNEpinephrine8GGN-β2-Epinephrine
18.52Single8GGOEpinephrine8GGO-β2-Epinephrine
18.52Single8GGUEpinephrine8GGU-β2-Epinephrine
18.52Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/&β;1/&γ;2
18.52Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/&β;1/&γ;2
18.52Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2
18.52Single8J18(3R)-3-hydroxydodecanoic acid8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
18.52Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
18.52Single8JJOAlprenolol8JJO-β2-Alprenolol
18.52Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2
18.52Single8JLZST19368JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
18.52Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
18.52Single8K5DGSK2560738K5D-HCA2-GSK256073
18.52Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/&β;1/&γ;2
18.52Single8UNMEpinephrine8UNM-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
18.52Single8UNNEpinephrine8UNN-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
18.52Single8UNPEpinephrine8UNP-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
18.52Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
18.52Single8X63Mepyramine8X63-H1-Mepyramine
18.52Single8X64Desloratadine8X64-H1-Desloratadine
18.52Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
18.52Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
18.52Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
18.52Consensusadrenergic_onOrthosteric Ligandbeta_on alpha_on
18.52Consensusamine_onOrthosteric Ligandadrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on
18.52Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
18.52Consensusblt_onOrthosteric Ligandblt1_on
18.52Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
18.52Consensusdopamine_onOrthosteric Ligandd3_on d2_on d5_on d1_on
18.52Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
18.52Consensushca3_onOrthosteric Ligand8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
18.52Consensusleuko_onOrthosteric Ligandblt_on
18.52Consensusprostanoid_offOrthosteric Ligandep_off tp_off dp_off
18.52Consensustachykinin_offOrthosteric Ligandnk1_off
18.52Consensustp_offOrthosteric Ligand6IIV-TP-Daltroban 6IIU-TP-Ramatroban
18.42Single6LMLGlucagon6LML-Glucagon-Glucagon
18.42Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
18.42Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
18.42Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
18.42Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
18.42Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
18.42Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
18.42Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
18.18Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.18Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/&β;1/&γ;2
17.95Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
17.95Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
17.86Single4JKVTaladegib (LY2940680)4JKV-SMO-Taladegib (LY2940680)
17.86Single4NTJAZD12834NTJ-P2Y12-AZD1283
17.86Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
17.86Single5TVNLSD5TVN-5-HT2B-LSD
17.86Single5WQCEMPA5WQC-OX2-EMPA
17.86Single5ZK3Quinuclidinyl benzilate hydrobromide5ZK3-M2-Quinuclidinyl benzilate hydrobromide
17.86Single6E67BI1671076E67-β2-BI167107-Gs (fused)
17.86Single6GDGNECA6GDG-A2A-NECA-Gs/&β;1/&γ;1
17.86Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
17.86Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
17.86Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
17.86Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
17.86Single6PS3(S)-Carvedilol6PS3-β2-(S)-Carvedilol
17.86Single6PS6Timolol6PS6-β2-Timolol
17.86Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
17.86Single6TP6Filorexant6TP6-OX1-Filorexant
17.86Single6Z4SSR486926Z4S-NTS1-SR48692
17.86Single7BVQ(S)-Carazolol7BVQ-β1-(S)-Carazolol
17.86Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
17.86Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
17.86Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2
17.86Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
17.86Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
17.86Single7WC6LSD7WC6-5-HT2A-LSD
17.86Single7YXAONO-54306087YXA-S1P5-ONO-5430608
17.86Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
17.86Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
17.86Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
17.86Single8J19PubChem 1270454228J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
17.86Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.86Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.86Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
17.86Consensusa2a_onOrthosteric Ligand6GDG-A2A-NECA-Gs/&β;1/&γ;1
17.86Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
17.86Consensusbeta2_onOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
17.86Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
17.86Consensusgi_adrenergicOrthosteric Ligand7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
17.86Consensusgs_adrenergicOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJI-β3-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
17.65Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
17.65Single7F4DAlpha-MSH7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
17.65Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
17.65Consensusmc5_onOrthosteric Ligand8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
17.50Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
17.39Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
17.39Single6TQ9SB-4081246TQ9-OX1-SB-408124
17.39Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
17.39Single7VDMSubstance P7VDM-MRGPRX2-Substance P-Gi1/&β;1/&γ;2
17.39Single8A2OTheophylline8A2O-A2A-Theophylline-Na
17.24Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
17.24Single3UONQuinuclidinyl benzilate hydrobromide3UON-M2-Quinuclidinyl benzilate hydrobromide
17.24Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
17.24Single4U15Tiotropium4U15-M3-Tiotropium
17.24Single5V57TC1145V57-SMO-TC114
17.24Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
17.24Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
17.24Single6E59L-7607356E59-NK1-L-760735
17.24Single6H7JIsoprenaline6H7J-β1-Isoprenaline
17.24Single6J20Aprepitant6J20-NK1-Aprepitant
17.24Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
17.24Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
17.24Single6OL9Tiotropium6OL9-M5-Tiotropium
17.24Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
17.24Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
17.24Single7B6WCyclazosin7B6W-α1b-Cyclazosin
17.24Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2
17.24Single7EPENAM5637EPE-mGlu-NAM563
17.24Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2
17.24Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2
17.24Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
17.24Single7W41PD1762527W41-BB2-PD176252
17.24Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/&β;1/&γ;2
17.24Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
17.24Single8JXWVUF68848JXW-H4-VUF6884-Gi1/&β;1/&γ;2
17.24Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/&β;1/&γ;2
17.24Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
17.24Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
17.24Consensus5ht5_offOrthosteric Ligand5ht5a_off
17.24Consensusalpha1b_offOrthosteric Ligand7B6W-α1b-Cyclazosin
17.24Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
17.24Consensusbombesin_offOrthosteric Ligandbb2_off
17.24Consensusgs_ffaOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2 8GDB-EP4-PGE2-Gs/&β;1/&γ;2
17.24Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl Scopolamine 5ZHP-M3-PubChem 134828589
17.24Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
17.24Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
17.24Consensuss1p2_onOrthosteric Ligand7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
17.24Consensussst4_onOrthosteric Ligand7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
17.14Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
17.14Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
17.07Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
17.07Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
17.07Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
17.07Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
16.67Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
16.67Single3OE8IT1t3OE8-CXCR4-IT1t
16.67Single4LDEBI1671074LDE-β2-BI167107
16.67Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
16.67Single5CXVTiotropium5CXV-M1-Tiotropium
16.67Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
16.67Single6CM4Risperidone6CM4-D2-Risperidone
16.67Single6H7N(S)-Xamoterol6H7N-β1-(S)-Xamoterol
16.67Single6IIURamatroban6IIU-TP-Ramatroban
16.67Single6ME5Agomelatine6ME5-MT1-Agomelatine
16.67Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
16.67Single6ZG4HTL00099366ZG4-M1-HTL0009936
16.67Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2
16.67Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2
16.67Single7K15MKD0467K15-BLT1-MKD046-Na
16.67Single7MT8All-trans-retinal7MT8-Rhodopsin-All-trans-retinal-GRK1
16.67Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
16.67Single7S8O(R)-Zinc-35737S8O-MRGPRX2-(R)-Zinc-3573-Gi1/&β;1/&γ;2
16.67Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
16.67Single7WC5Psilocin7WC5-5-HT2A-Psilocin
16.67Single7XMTJ-21567XMT-SST4-J-2156-Gi1/&β;1/&γ;2
16.67Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
16.67Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/&β;1/&γ;2
16.67Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67Single8F76-8F76-OR51E2-Gs/&β;1/&γ;2
16.67Single8GGREpinephrine8GGR-β2-Epinephrine
16.67Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
16.67Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
16.67Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Single8JWYPubChem 1684517108JWY-A2A-PubChem 168451710
16.67Single8JWZAB9288JWZ-A2A-AB928-Na
16.67Single8POKHistamine8POK-H2-Histamine-Gs/&β;1/&γ;2
16.67Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg3_on
16.67Consensusblt1_offOrthosteric Ligand7K15-BLT1-MKD046-Na
16.67Consensusblt_offOrthosteric Ligandblt1_off
16.67Consensusclass-b2_onOrthosteric Ligandadgrg_on
16.67Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
16.67Consensusgpr119_onOrthosteric Ligand7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
16.67Consensusgs_trhOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
16.67Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
16.67Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
16.67Consensussmo_off_alloOrthosteric Ligand6D32-SMO-Cyclopamine-Cyclopamine
16.67Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
16.67Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
16.22Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
16.22Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
16.22Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
16.22Single7D3SSecretin7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
16.22Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
16.22Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
16.22Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
16.22Consensusclass-d_onOrthosteric Ligandste2_on
16.13Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
16.13Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
16.13Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
16.13Single6H7LDobutamine6H7L-β1-Dobutamine
16.13Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/&β;1/&γ;2
16.13Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
16.13Single7UM4AS26747237UM4-5-HT5A-AS2674723
16.13Single7XZ6APD6687XZ6-GPR119-APD668-Gs/&β;1/&γ;2
16.13Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.13Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
16.13Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.13Consensus5ht5a_offOrthosteric Ligand7UM4-5-HT5A-AS2674723
16.13Consensusadgrg2_onOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
16.00Single3PBLEticlopride3PBL-D3-Eticlopride
16.00Single5L7IVismodegib5L7I-SMO-Vismodegib
16.00Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
16.00Single6HLLCP999946HLL-NK1-CP99994
16.00Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
16.00Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
16.00Single6QNOAll-trans-retinal6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
16.00Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
16.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
16.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
16.00Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2
16.00Single7SRQLSD7SRQ-5-HT2B-LSD
16.00Single7UL2SR486927UL2-NTS1-SR48692-Na
16.00Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/&β;1/&γ;2
16.00Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2
16.00Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.00Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.00Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
16.00Single8GEIEpinephrine8GEI-β2-Epinephrine-Gs/&β;1/&γ;2
16.00Single8GGSEpinephrine8GGS-β2-Epinephrine
16.00Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2
16.00Single8HN8Histamine8HN8-H4-Histamine-Gi1/&β;1/&γ;2
16.00Single8ITFDMCHA8ITF-TAAR9-DMCHA-chim(NtGi1-Gs)/&β;1/&γ;2
16.00Single8IY9Niacin8IY9-HCA2-Niacin-Go/&β;1/&γ;2
16.00Single8JILNiacin8JIL-HCA2-Niacin-Gi1/&β;1/&γ;2
16.00Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
16.00Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
16.00Single8K5BNiacin8K5B-HCA2-Niacin
16.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
16.00Single8UNVEpinephrine8UNV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
16.00Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
16.00Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/&β;1/&γ;2
16.00Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
16.00Consensusgo_adhesionOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
16.00Consensusgo_class-b2Orthosteric Ligandgo_adhesion
16.00Consensusmt1_onOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
16.00Consensusmt2_onOrthosteric Ligand7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
16.00Consensusnts1_off_alloOrthosteric Ligand7UL2-NTS1-SR48692-Na
16.00Consensusox1_off_alloOrthosteric Ligand6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na 6TO7-OX1-Suvorexant-Na
16.00Consensussmo_on_alloOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
15.91Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
15.79Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
15.79Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
15.79Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
15.79Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
15.79Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
15.79Consensusgi_class-dOrthosteric Ligandgi_ste
15.79Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
15.62Single8IYHMK68928IYH-HCA2-MK6892-Go/&β;1/&γ;2
15.62Consensusgs_adgrOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
15.62Consensusgs_bombesinOrthosteric Ligand8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.62Consensusgs_class-b2Orthosteric Ligandgs_adgr
15.56Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
15.38Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
15.38Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
15.38Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
15.38Single3PWHZM2413853PWH-A2A-ZM241385
15.38Single4S0VSuvorexant4S0V-OX2-Suvorexant
15.38Single5DHHSB-6121115DHH-NOP-SB-612111
15.38Single5U09Taranabant5U09-CB1-Taranabant
15.38Single6KUXRS-799486KUX-α2a-RS-79948
15.38Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
15.38Single6OBA(S)-Alprenolol6OBA-β2-(S)-Alprenolol-GTPL11074
15.38Single6OYAAll-trans-retinal6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
15.38Single6TODEMPA6TOD-OX1-EMPA-Na
15.38Single6TPJSuvorexant6TPJ-OX2-Suvorexant
15.38Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
15.38Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2
15.38Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2
15.38Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/&β;1/&γ;2
15.38Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
15.38Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
15.38Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
15.38Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
15.38Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
15.38Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
15.38Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
15.38Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.38Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
15.38Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
15.38Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
15.38Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
15.38Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
15.38Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
15.38Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2
15.38Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
15.38Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2
15.38Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2
15.38Single8DWHCompound-168DWH-MRGPRX1-Compound-16-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.38Single8GECEpinephrine8GEC-β2-Epinephrine-Gs/&β;1/&γ;2
15.38Single8GEDEpinephrine8GED-β2-Epinephrine-Gs/&β;1/&γ;2
15.38Single8GEFEpinephrine8GEF-β2-Epinephrine-Gs/&β;1/&γ;2
15.38Single8GG7Epinephrine8GG7-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
15.38Single8GG9Epinephrine8GG9-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
15.38Single8GGAEpinephrine8GGA-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
15.38Single8GGVEpinephrine8GGV-β2-Epinephrine
15.38Single8GGWEpinephrine8GGW-β2-Epinephrine
15.38Single8GGXEpinephrine8GGX-β2-Epinephrine
15.38Single8GH0Epinephrine8GH0-β2-Epinephrine
15.38Single8HOCImetit8HOC-H4-Imetit-Gi1/&β;1/&γ;2
15.38Single8IHKAcifran8IHK-HCA3-Acifran
15.38Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2
15.38Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
15.38Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
15.38Single8UNLEpinephrine8UNL-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
15.38Single8UNOEpinephrine8UNO-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
15.38Single8UNTEpinephrine8UNT-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
15.38Single8UNUEpinephrine8UNU-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
15.38Single8UNWEpinephrine8UNW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
15.38Single8UO1Epinephrine8UO1-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
15.38Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
15.38Consensusalpha2_offOrthosteric Ligandalpha2a_off alpha2c_off
15.38Consensusalpha2a_offOrthosteric Ligand6KUX-α2a-RS-79948
15.38Consensusbeta2_off_alloOrthosteric Ligand6OBA-β2-(S)-Alprenolol-GTPL11074
15.38Consensusclass-f_offOrthosteric Ligandsmo_off
15.38Consensuscrf1_onOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
15.38Consensusffa3_on_alloOrthosteric Ligand8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
15.38Consensusgi_histamineOrthosteric Ligand8HN8-H4-Histamine-Gi1/&β;1/&γ;2 8HOC-H4-Imetit-Gi1/&β;1/&γ;2
15.38Consensusgs_5htOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2 7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2 7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.38Consensusgs_histamineOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.38Consensusgt_class-aOrthosteric Ligandgt_opsin
15.38Consensusgt_opsinOrthosteric Ligandgt_sensory
15.38Consensusgt_sensoryOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
15.38Consensush4_onOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.38Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
15.38Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
15.15Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
15.15Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
15.00Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
14.89Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
14.81Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
14.81Single3REYPubChem 56973REY-A2A-PubChem 5697
14.81Single3RZECidoxepin3RZE-H1-Cidoxepin
14.81Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
14.81Single6A94Zotepine6A94-5-HT2A-Zotepine
14.81Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
14.81Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
14.81Single6IQLL7458706IQL-D4-L745870
14.81Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
14.81Single6TP3Nemorexant6TP3-OX1-Nemorexant
14.81Single6V9SGTPL114036V9S-OX1-GTPL11403
14.81Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
14.81Single6ZDVPubChem 9840736ZDV-A2A-PubChem 984073-Na
14.81Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
14.81Single6ZG9GSK10347026ZG9-M1-GSK1034702
14.81Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
14.81Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
14.81Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2
14.81Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
14.81Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.81Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
14.81Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2
14.81Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
14.81Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
14.81Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
14.81Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
14.81Single8GE1Epinephrine8GE1-β2-Epinephrine-Gs/&β;1/&γ;2
14.81Single8GE4Epinephrine8GE4-β2-Epinephrine-Gs/&β;1/&γ;2
14.81Single8GE6Epinephrine8GE6-β2-Epinephrine-Gs/&β;1/&γ;2
14.81Single8GE7Epinephrine8GE7-β2-Epinephrine-Gs/&β;1/&γ;2
14.81Single8GE8Epinephrine8GE8-β2-Epinephrine-Gs/&β;1/&γ;2
14.81Single8GE9Epinephrine8GE9-β2-Epinephrine-Gs/&β;1/&γ;2
14.81Single8GFVEpinephrine8GFV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
14.81Single8GG3Epinephrine8GG3-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
14.81Single8GG4Epinephrine8GG4-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
14.81Single8GG5Epinephrine8GG5-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
14.81Single8GG8Epinephrine8GG8-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
14.81Single8GGIEpinephrine8GGI-β2-Epinephrine
14.81Single8GGLEpinephrine8GGL-β2-Epinephrine
14.81Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2
14.81Single8HQN9(S)-HODE8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
14.81Single8JERAcipimox8JER-HCA2-Acipimox-Go/&β;1/&γ;2
14.81Single8JLNT1AM8JLN-TA1-T1AM-Gs/&β;1/&γ;2
14.81Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
14.81Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2
14.81Single8K5CAcipimox8K5C-HCA2-Acipimox
14.81Single8UHBRO52563908UHB-TA1-RO5256390-Gs/&β;1/&γ;2
14.81Single8UNQEpinephrine8UNQ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
14.81Single8UNREpinephrine8UNR-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
14.81Single8UNSEpinephrine8UNS-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
14.81Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.81Consensus5ht2a_onOrthosteric Ligand7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.81Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
14.81Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
14.81Consensusm1_off_alloOrthosteric Ligand6WJC-M1-Atropine-Muscarinic toxin 7
14.81Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
14.81Consensussensory_offOrthosteric Ligandopsin_off
14.71Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
14.29Single2Y01Dobutamine2Y01-β1-Dobutamine
14.29Single2Y04Salbutamol2Y04-β1-Salbutamol
14.29Single4DAJTiotropium4DAJ-M3-Tiotropium
14.29Single4MQSIperoxo4MQS-M2-Iperoxo
14.29Single4QKXPubChem 762106284QKX-β2-PubChem 76210628
14.29Single4U14Tiotropium4U14-M3-Tiotropium
14.29Single4U16N-Methyl Scopolamine4U16-M3-N-Methyl Scopolamine
14.29Single4YAYZD-71554YAY-AT1-ZD-7155
14.29Single5DHGPubChem 250014125DHG-NOP-PubChem 25001412
14.29Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
14.29Single5UIGJ3.651.884G5UIG-A2A-J3.651.884G
14.29Single5YC8N-Methyl Scopolamine5YC8-M2-N-Methyl Scopolamine
14.29Single5ZK8N-Methyl Scopolamine5ZK8-M2-N-Methyl Scopolamine
14.29Single5ZKCN-Methyl Scopolamine5ZKC-M2-N-Methyl Scopolamine
14.29Single6DRXLisuride6DRX-5-HT2B-Lisuride
14.29Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
14.29Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
14.29Single6GPSMK08126GPS-CCR2-MK0812
14.29Single6H7MSalbutamol6H7M-β1-Salbutamol
14.29Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
14.29Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
14.29Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
14.29Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2
14.29Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
14.29Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
14.29Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
14.29Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
14.29Single8EJKTAK-8758EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
14.29Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/&β;1/&γ;2
14.29Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Single8UO4Epinephrine8UO4-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
14.29Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Consensus5ht1a_onOrthosteric Ligand8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
14.29Consensusgi_5htOrthosteric Ligand7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
14.29Consensusgo_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
14.29Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
14.29Consensushistamine_onOrthosteric Ligandh1_on h4_on
14.29Consensusm2_on_alloOrthosteric Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
14.29Consensusm4_on_alloOrthosteric Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
14.29Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
13.89Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
13.89Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
13.89Consensusclass-d_onOrthosteric Ligandste2_on
13.89Consensusgi_class-dOrthosteric Ligandgi_ste
13.89Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
13.89Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
13.79Single2Y00Dobutamine2Y00-β1-Dobutamine
13.79Single2Y03Isoprenaline2Y03-β1-Isoprenaline
13.79Single5WIUNemonapride5WIU-D4-Nemonapride
13.79Single5WIVNemonapride5WIV-D4-Nemonapride-Na
13.79Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
13.79Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
13.79Single6GPXMK08126GPX-CCR2-MK0812
13.79Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
13.79Single7SINNPS-21437SIN-CaS-NPS-2143
13.79Single7SINNPS-21437SIN-CaS-NPS-2143
13.79Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2
13.79Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.79Single8EA0Iperoxo8EA0-M3-Iperoxo
13.79Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2
13.79Single8GDCPGE28GDC-EP3-PGE2-Gi1/&β;1/&γ;2
13.79Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2
13.79Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide 6DRX-5-HT2B-Lisuride
13.79Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
13.79Consensusd4_offOrthosteric Ligand5WIU-D4-Nemonapride
13.79Consensusd4_off_alloOrthosteric Ligand5WIV-D4-Nemonapride-Na
13.79Consensusep3_onOrthosteric Ligand8GDC-EP3-PGE2-Gi1/&β;1/&γ;2
13.79Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
13.79Consensusep_offOrthosteric Ligandep4_off
13.79Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
13.79Consensusgs_muscarinicOrthosteric Ligand8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.79Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
13.79Consensusm2_offOrthosteric Ligand5ZKB-M2-AF-DX 384 5ZKC-M2-N-Methyl Scopolamine 5ZK3-M2-Quinuclidinyl benzilate hydrobromide
13.79Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.64Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
13.64Single8WCCCyclohexylammonium ion8WCC-TA1-Cyclohexylammonium ion
13.51Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
13.51Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
13.33Single5TZR-5TZR-FFA1 (GPR40)-MK8666
13.33Single5V54Methiothepin5V54-5-HT1B-Methiothepin
13.33Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
13.33Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
13.33Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
13.33Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
13.33Single8EFLSR170188EFL-μ-SR17018-Gi1/&β;1/&γ;2
13.33Single8JD0J9R8JD0-mGlu2; mGlu3-Glutamate-J9R
13.33Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
13.33Consensus5ht1_offOrthosteric Ligand5ht1b_off
13.33Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
13.16Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
13.16Consensusghrh_onOrthosteric Ligand7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
13.04Single3PXOAll-trans-retinal3PXO-Rhodopsin-All-trans-retinal
13.04Single5DYSAll-trans-retinal5DYS-Rhodopsin-All-trans-retinal
13.04Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
13.04Single7WC4Serotonin7WC4-5-HT2A-Serotonin
13.04Single8GEJEpinephrine8GEJ-β2-Epinephrine-Gs/&β;1/&γ;2
13.04Single8HSCFab0468HSC-GPR20-Fab046-Gi1/&β;1/&γ;2
13.04Single8PWNTheophylline8PWN-A2A-Theophylline
12.90Single4N4WSANT-14N4W-SMO-SANT-1
12.90Single5X33BIIL2605X33-BLT1-BIIL260
12.90Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
12.90Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
12.90Single8GCPPGE28GCP-EP4-PGE2-Gi1/&β;1/&γ;2
12.90Consensusbeta1_onOrthosteric Ligand7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
12.90Consensusgi_prostanoidOrthosteric Ligand8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GDC-EP3-PGE2-Gi1/&β;1/&γ;2 8GCM-EP4-L902688-Gi1/&β;1/&γ;2
12.82Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
12.77Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
12.50Single2HPYAll-trans-retinal2HPY-Rhodopsin-All-trans-retinal
12.50Single3RFMCaffeine3RFM-A2A-Caffeine
12.50Single6OY9All-trans-retinal6OY9-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
12.50Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
12.50Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.50Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
12.50Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/&β;1/&γ;2
12.50Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50Single8WC5Tetramethylammonium ion8WC5-TA1-Tetramethylammonium ion-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Consensuscalcitonin_onOrthosteric Ligandct_on ctlike_on
12.50Consensusep4_onOrthosteric Ligand7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2
12.50Consensusgs_lipidOrthosteric Ligandgs_ffa gs_prostanoid
12.50Consensusgs_prostanoidOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50Consensushca2_on_alloOrthosteric Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
12.50Consensussensory_onOrthosteric Ligandopsin_on
12.12Single5EE7MK08935EE7-Glucagon-MK0893
12.00Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
12.00Single3PQRAll-trans-retinal3PQR-Rhodopsin-All-trans-retinal-Gt(CT)
12.00Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
12.00Single6FUFAll-trans-retinal6FUF-Rhodopsin-All-trans-retinal-Go/&β;1/&γ;2
12.00Single6LI0GTPL98046LI0-GPR52-GTPL9804
12.00Single6ME9Ramelteon6ME9-MT2-Ramelteon
12.00Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/&β;1/&γ;2
12.00Single7MT9All-trans-retinal7MT9-Rhodopsin-All-trans-retinal-GRK1
12.00Single7MTAAll-trans-retinal7MTA-Rhodopsin-All-trans-retinal-GRK1
12.00Single8EITDoconexent8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
12.00Single8GGZEpinephrine8GGZ-β2-Epinephrine
12.00Single8J6QBeta-hydroxybutyrate8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
12.00Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/&β;1/&γ;2
12.00Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
12.00Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/&β;1/&γ;2
12.00Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
12.00Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.00Consensusopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
11.90Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
11.76Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
11.76Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
11.54Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
11.54Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
11.54Single2G87All-trans-retinal2G87-Rhodopsin-All-trans-retinal
11.54Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
11.54Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
11.54Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
11.54Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
11.54Single6TP4ACT-4622066TP4-OX1-ACT-462206
11.54Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
11.54Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
11.54Single7S8N(R)-Zinc-35737S8N-MRGPRX2-(R)-Zinc-3573-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.54Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
11.54Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/&β;1/&γ;2
11.54Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
11.54Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.54Single8GGYEpinephrine8GGY-β2-Epinephrine
11.54Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2
11.54Single8UNXEpinephrine8UNX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
11.54Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
11.54Single8X2K5YM8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
11.54Consensus5ht4_onOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
11.43Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
11.43Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
11.36Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
11.11Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
11.11Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
11.11Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
11.11Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/&β;1/&γ;2
11.11Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
11.11Single6ME2Ramelteon6ME2-MT1-Ramelteon
11.11Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
11.11Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;1
11.11Single8A6CAll-trans-retinal8A6C-Rhodopsin-All-trans-retinal
11.11Single8A6DAll-trans-retinal8A6D-Rhodopsin-All-trans-retinal
11.11Single8A6EAll-trans-retinal8A6E-Rhodopsin-All-trans-retinal
11.11Single8GEAEpinephrine8GEA-β2-Epinephrine-Gs/&β;1/&γ;2
11.11Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/&β;1/&γ;2
11.11Single8HMPPubChem 699214798HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
11.11Single8IW4Spermidine8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2
11.11Single8IWESpermidine8IWE-TAAR9-Spermidine
11.11Consensus5ht2_onOrthosteric Ligand5ht2a_on 5ht2c_on
11.11Consensus5ht2c_onOrthosteric Ligand8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.11Consensusopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
10.81Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
10.71Single6TPKRetosiban6TPK-OT-Retosiban
10.71Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
10.71Single7VODCariprazine7VOD-5-HT2A-Cariprazine
10.71Single7VVOPTH7VVO-PTH1-PTH-Gs/&β;1/&γ;2
10.71Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
10.71Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.71Single8GCML9026888GCM-EP4-L902688-Gi1/&β;1/&γ;2
10.71Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.71Single8K2WAMG4878K2W-CXCR3-AMG487
10.71Single8T3VDHA8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.71Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
10.71Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
10.71Consensusvasopressin-ot_offOrthosteric Ligandot_off
10.42Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
10.34Single5DSGTiotropium5DSG-M4-Tiotropium
10.34Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/&β;1/&γ;2
10.34Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.34Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
10.34Single7F83PF-051904577F83-Ghrelin-PF-05190457
10.34Single8EJCTAK-8758EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
10.34Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-alpha-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
10.34Consensushcar_offOrthosteric Ligandsuccinate_off
10.34Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
10.34Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
10.20Consensusgs_ctOrthosteric Ligand7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
10.00Single4PHUFasiglifam4PHU-FFA1 (GPR40)-Fasiglifam
10.00Single4WW3All-trans-retinal4WW3-Rhodopsin-All-trans-retinal
10.00Single5CGCHTL142425CGC-mGlu5-HTL14242
10.00Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
10.00Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
10.00Single6LUQHaloperidol6LUQ-D2-Haloperidol
10.00Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
10.00Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
10.00Single8GDAL9026888GDA-EP4-L902688-Gs/&β;1/&γ;2
10.00Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
10.00Consensusccr2_off_alloOther Ligand5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
10.00Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
9.76Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
9.68Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2
9.68Single7P2L4YI7P2L-mGlu5-4YI
9.68Single8GDBPGE28GDB-EP4-PGE2-Gs/&β;1/&γ;2
9.68Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
9.68Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
9.68Single8X79MRE-2698X79-I2-MRE-269-Gs/&β;1/&γ;2
9.52Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
9.52Single7TYIAmylin7TYI-CT-Amylin-Gs/&β;1/&γ;2
9.52Single7TYLAmylin7TYL-CT-Amylin-Gs/&β;1/&γ;2
9.52Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
9.38Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
9.38Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
9.38Consensusep_onOrthosteric Ligandep4_on ep2_on ep3_on
9.38Consensusprostanoid_onOrthosteric Ligandep_on fpa_on
9.09Single5CGDHTL142425CGD-mGlu5-HTL14242
9.09Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2
9.09Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
9.09Single8HS2Fab0468HS2-GPR20-Fab046
9.09Consensusep2_onOrthosteric Ligand7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
9.09Consensusfpa_onOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.89Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
8.89Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
8.82Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.82Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.70Single4A4MAll-trans-retinal4A4M-Rhodopsin-All-trans-retinal-Gt(CT)
8.70Single5EN0All-trans-retinal5EN0-Rhodopsin-All-trans-retinal-Gt(CT)
8.70Single5MZPCaffeine5MZP-A2A-Caffeine-Na
8.70Single8WCBCyclohexylammonium ion8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.57Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
8.51Single8F2APramlintide analogue san3858F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
8.33Single7XKEBetahydroxyandrosterone7XKE-ADGRG2-Betahydroxyandrosterone-chim(NtGi1-Gs)/&β;1/&γ;2
8.33Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
8.33Consensusgabab_offOther Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
8.00Single7MTBAll-trans-retinal7MTB-Rhodopsin-All-trans-retinal-GRK1
8.00Single7XKDBetahydroxyandrosterone7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
8.00Single7Y14Beta-alanine7Y14-MRGPRD-Beta-alanine
8.00Single8F2BPramlintide analogue san458F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
8.00Single8IWM2-Phenylethylamine8IWM-TAAR9-2-Phenylethylamine
7.69Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
7.69Single3UZAGTPL92363UZA-A2A-GTPL9236
7.69Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
7.69Single7Y12Beta-alanine7Y12-MRGPRD-Beta-alanine-Gi1/&β;1/&γ;2
7.69Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.69Single8F0JPramlintide analogue san458F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2
7.69Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/&β;1/&γ;2
7.69Single8IW72-Phenylethylamine8IW7-TAAR9-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
7.69Consensusadgrg3_onOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
7.41Single3AYMAll-trans-retinal3AYM-Rhodopsin-All-trans-retinal
7.41Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
7.41Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
7.41Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
7.14Single8U8FPML8U8F-GPR3-PML-Gs/&β;1/&γ;2
7.14Consensussmo_on_alloOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
6.98Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/&β;1/&γ;2; RAMP2
6.90Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/&β;1/&γ;2
6.67Single8F0KPramlintide analogue san3858F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
6.67Consensusffa1_onOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.25Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.25Consensusmglu2_onOther Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
6.06Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1
5.88Single7CX2PGE27CX2-EP2-PGE2-Gs/&β;1/&γ;2
4.76Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
4.76Single6D35Cholesterol6D35-SMO-Cholesterol
4.76Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
4.76Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
4.76Single6UO8SKF975416UO8-GABAB1, GABAB2-SKF97541-GS39783
4.76Single6UO9SKF975416UO9-GABAB1, GABAB2-SKF97541
4.76Single6W2XPubChem 53110426W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
4.76Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
4.76Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
4.76Single7C7QBaclofen7C7Q-GABAB1, GABAB2-Baclofen-PubChem 7023848
4.76Single7C7SCGP546267C7S-GABAB1, GABAB2-CGP54626
4.76Single7CUMCGP546267CUM-GABAB1, GABAB2-CGP54626-Phospholipid
4.76Single7DD5Ca37DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
4.76Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
4.76Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
4.76Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
4.76Single7DGEQuisqualate7DGE-mGlu1; mGlu1-Quisqualate
4.76Single7DTTCa7DTT-CaS-Ca-Ca
4.76Single7DTTCa7DTT-CaS-Ca-Ca
4.76Single7DTUTryptophan7DTU-CaS-Tryptophan
4.76Single7DTUTryptophan7DTU-CaS-Tryptophan
4.76Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
4.76Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
4.76Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
4.76Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
4.76Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.76Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.76Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.76Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.76Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
4.76Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
4.76Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
4.76Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
4.76Single7EB2Baclofen7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
4.76Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
4.76Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
4.76Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
4.76Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
4.76Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
4.76Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
4.76Single7FIHhCG7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
4.76Single7FIIhCG7FII-LH-hCG-6fuf
4.76Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
4.76Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
4.76Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
4.76Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
4.76Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.76Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.76Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.76Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.76Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
4.76Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
4.76Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
4.76Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
4.76Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
4.76Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
4.76Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
4.76Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
4.76Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
4.76Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
4.76Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.76Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.76Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.76Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.76Single7T9NM22 Fab7T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
4.76Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
4.76Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
4.76Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
4.76Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
4.76Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
4.76Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
4.76Single7XW6M22 Fab7XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
4.76Single7XW7K1-707XW7-TSH-K1-70
4.76Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
4.76Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
4.76Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
4.76Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
4.76Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
4.76Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
4.76Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
4.76Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
4.76Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
4.76Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
4.76Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
4.76Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
4.76Single8JD0Glutamate8JD0-mGlu2; mGlu3-Glutamate-J9R
4.76Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
4.76Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
4.76Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
4.76Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
4.76Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
4.76Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
4.76Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
4.76Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
4.76Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
4.76Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
4.76Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
4.76Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
4.76Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
4.76Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
4.76Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
4.76Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
4.76Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
4.76Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
4.76Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
4.76Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
4.76Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
4.76Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
4.76Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
4.76Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
4.76Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
4.76Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
4.76Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
4.76Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
4.76Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
4.76Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.76Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.76Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
4.76Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
4.76Consensusclass-c_offOrthosteric Ligandgabab_off mglu_off
4.76Consensusclass-c_offOrthosteric Ligandgabab_off mglu_off
4.76Consensusclass-c_onOrthosteric Ligandgabab_on mglu_on
4.76Consensusclass-c_onOrthosteric Ligandgabab_on mglu_on
4.76Consensusfsh_on_alloOrthosteric Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
4.76Consensusgabab_offOrthosteric Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
4.76Consensusgabab_onOrthosteric Ligand7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
4.76Consensusgi_class-cOrthosteric Ligandgi_mglu gi_gaba
4.76Consensusgi_class-cOrthosteric Ligandgi_mglu gi_gaba
4.76Consensusgi_gabaOrthosteric Ligand7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
4.76Consensusgi_mgluOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
4.76Consensusgi_mgluOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
4.76Consensusgphr_onOrthosteric Ligandlh_on tsh_on
4.76Consensusgs_gphrOrthosteric Ligand7T9I-TSH-TSH-Gs/&β;1/&γ;2 7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
4.76Consensusgs_proteinOrthosteric Ligandgs_gphr
4.76Consensuslh_onOrthosteric Ligand7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
4.76Consensuslh_on_alloOrthosteric Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
4.76Consensusmglu2_offOrthosteric Ligand7MTQ-mGlu2; mGlu2-LY341495
4.76Consensusmglu2_offOrthosteric Ligand7MTQ-mGlu2; mGlu2-LY341495
4.76Consensusmglu2_onOrthosteric Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
4.76Consensusmglu2_onOrthosteric Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
4.76Consensusmglu3_offOrthosteric Ligand7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
4.76Consensusmglu3_offOrthosteric Ligand7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
4.76Consensusmglu4_onOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
4.76Consensusmglu4_onOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
4.76Consensusmglu5_offOrthosteric Ligand7FD9-mGlu5; mGlu5-LY341495
4.76Consensusmglu5_offOrthosteric Ligand7FD9-mGlu5; mGlu5-LY341495
4.76Consensusmglu_offOrthosteric Ligandmglu2_off mglu3_off mglu5_off
4.76Consensusmglu_offOrthosteric Ligandmglu2_off mglu3_off mglu5_off
4.76Consensusmglu_onOrthosteric Ligandmglu2_on mglu4_on
4.76Consensusmglu_onOrthosteric Ligandmglu2_on mglu4_on
4.76Consensussmo_off_alloOther Ligand6D32-SMO-Cyclopamine-Cyclopamine
4.76Consensustsh_onOrthosteric Ligand7T9I-TSH-TSH-Gs/&β;1/&γ;2
4.76Consensustsh_on_alloOrthosteric Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
4.55Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
4.55Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
4.55Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
4.55Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
4.55Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.55Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.55Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.55Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.55Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
4.55Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
4.35Single7KNUCalcitonin gene-related peptide-17KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
4.35Single7T9MCS-17 Antibody7T9M-TSH-CS-17 Antibody
4.17Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
4.17Single6W25Ca6W25-MC4-SHU9119-Ca
4.17Single7FIGhCG7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
4.17Single7UTZTR14027UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
4.17Single7XW5TSH7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
4.17Single7ZI0Cholesterol7ZI0-SMO-SAG-Cholesterol
4.17Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
4.17Consensusccr8_offOrthosteric Ligand8TLM-CCR8-Anti-murine CCR8 antibody
4.00Single5L7DCholesterol5L7D-SMO-Cholesterol
4.00Single7T9ITSH7T9I-TSH-TSH-Gs/&β;1/&γ;2
4.00Single8I2GGlycoprotein hormones alpha chain8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
4.00Consensusclass-c_onOther Ligandgabab_on mglu_on
3.70Consensusgip_on_alloOther Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
3.57Single7XKFBetahydroxyandrosterone7XKF-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
3.57Single8J6QCompound 9n8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
3.57Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
3.57Consensushca2_on_alloOther Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
3.45Single4K5YCP-3763954K5Y-CRF1-CP-376395
3.45Single4XNVBPTU4XNV-P2Y1-BPTU
3.45Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
3.45Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2
3.33Single6FFIMMPEP6FFI-mGlu5-MMPEP
3.33Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
3.33Single8IYXYL-3658IYX-GPR34-YL-365
3.23Single4Z9GCP-3763954Z9G-CRF1-CP-376395
3.23Single6FFHFenobam6FFH-mGlu5-Fenobam
3.23Single8GTIBMK-C2058GTI-CRF1-BMK-C205
3.12Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
3.12Single8GTGBMK-I1528GTG-CRF1-BMK-I152
3.03Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
3.03Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
3.03Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
2.94Single8GTMBMK-C2038GTM-CRF1-BMK-C203
2.94Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
2.63Single7SHEPI; PE7SHE-GPR158-PI; PE

Consensus Members
Id Members
8HCQ 8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
Net Summary
Imin 2.94
Number of Linked Nodes 284
Number of Links 314
Number of Hubs 31
Number of Links mediated by Hubs 145
Number of Communities 10
Number of Nodes involved in Communities 67
Number of Links involved in Communities 87
Path Summary
Number Of Nodes in MetaPath 56
Number Of Links MetaPath 55
Number of Shortest Paths 35049
Length Of Smallest Path 3
Average Path Length 14.3769
Length of Longest Path 34
Minimum Path Strength 1.42
Average Path Strength 5.28226
Maximum Path Strength 20.525
Minimum Path Correlation 0.7
Average Path Correlation 0.932366
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 4.16667
Average % Of Corr. Nodes 52.5789
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 36.5656
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following consensuses:
IdComponents
endothelin_onetb_on
eta_on



You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download eta_on.zip



You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.



You can also  read or  download a guide explaining the meaning of all files and numerical data.