Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
11x43 5.462527
21x50 6.7425409
31x60 3.815406
42x38 4.492507
52x42 5.17167607
62x50 8.0375439
72x64 6.025404
8E1x50 5.95143718
93x30 4.51446
103x39 8.22439
113x41 5.13405
123x42 5.155408
133x50 6.8475409
143x51 8.59408
154x50 7.63409
16E2 18.73921313
175x47 7.226518
185x58 7.794508
196x48 7.634518
206x51 4.6225415
216x55 11.34415
22E3 9.52111913
237x42 7.37427
247x45 6.7409
257x46 5.975438
267x54 7.1875407
278x50 7.98409
288x54 8.9025407
29Lig 10.68691310
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
11x42 7x42 11.66496.28NoYes077
21x43 2x54 23.6464.28YesNo076
32x54 7x46 24.94074.5NoYes068
41x50 2x50 23.14145.39YesYes099
51x50 2x47 13.39744.69YesNo099
62x50 7x49 28.44815.39YesNo099
76x40 7x49 49.21893.62NoNo079
86x40 7x53 37.52368.53NoNo079
97x53 8x50 35.08613.4NoYes099
108x50 8x54 20.56418.57YesYes097
111x54 2x47 11.95673.25NoNo079
123x39 7x46 23.91344.59YesYes398
133x39 6x44 95.11287.44YesNo099
143x40 6x44 91.30756.55NoNo089
153x40 3x41 89.3383.93NoYes085
163x41 4x49 81.98296.28YesNo057
173x42 4x49 81.18054.56YesNo087
182x42 3x42 74.32373.89YesYes078
192x38 2x42 29.56663.93YesYes077
202x38 3x49 24.9658.76YesNo078
212x39 3x49 17.71326.44NoNo088
222x37 2x39 17.03248.15NoNo088
232x37 2x40 15.360813.62NoNo088
242x40 I1x50 13.6774.21NoNo087
251x60 I1x50 12.20596.09YesNo067
263x49 3x50 10.40675.96NoYes089
272x42 3x46 41.45047.31YesNo079
283x46 6x37 40.36237.45NoNo098
293x50 6x37 12.35183.92YesNo098
306x44 6x48 10014.03NoYes098
316x48 Lig 96.54738.24YesYes180
323x32 Lig 11.184710.38NoYes060
33E2 Lig 42.787713.06YesYes130
34E1x50 E2 14.28484.56YesYes183
354x61 Lig 15.409416.23NoYes150
363x33 4x61 14.01139.28NoNo045
373x33 4x57 12.47954.73NoNo047
383x30 4x57 10.93554.16YesNo067
393x39 7x45 30.84319.79YesYes099
403x41 5x46 11.14224.29YesNo056
415x58 6x37 36.65435.05YesNo088
425x58 5x61 26.861612.09YesNo088
433x51 5x61 17.78013.63YesNo088
443x50 3x53 11.34894.15YesNo098
45E2 E3 16.07211.91YesYes133
465x35 Lig 16.05988.23NoYes130
475x35 E3 14.88066.95NoYes133
486x55 Lig 12.388326.11YesYes150
496x52 Lig 20.04136.44NoYes170
505x47 6x52 10.88697.62YesNo187
516x36 6x40 10.01153.89NoNo087
527x30 E3 14.32138.82NoYes143
537x54 8x54 12.94159.28YesYes077
541x43 7x42 14.27887.54YesYes277
552x50 3x39 42.520211.06YesYes399
567x45 7x49 24.37548.17YesNo099
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
2x563x324.580NoNo7621
E1E212.780NoYes4321
E1x49E24.281NoYes4321
3x25E1x503.921NoYes9822
E1x50E24.561YesYes8321
3x22E219.170NoYes4321
3x25E24.761NoYes9321
3x26E29.681NoYes7321
3x283x324.120NoNo5621
3x294x616.291NoNo5511
3x294x655.341NoNo5512
3x29Lig10.971NoYes5010
3x32Lig10.380NoYes6010
3x334x619.280NoNo4521
3x366x484.90NoYes7821
4x61Lig16.231NoYes5010
4x65E2x525.340NoNo5421
E2E274.671YesYes3311
E2E2x514.391YesNo3112
E2E2x525.561YesNo3411
E2x52Lig15.541NoYes4010
6x58E24.120NoYes4321
E2E311.911YesYes3312
E2Lig13.061YesYes3010
5x35E36.951NoYes3312
5x35Lig8.231NoYes3010
5x385x424.181NoNo6612
5x386x556.531NoYes6511
5x38Lig7.161NoYes6010
5x426x557.631NoYes6521
5x435x478.251NoYes6822
5x436x526.791NoNo6721
5x476x527.621YesNo8721
6x446x4814.030NoYes9821
6x486x514.521YesYes8511
6x487x416.481YesNo8812
6x48Lig8.241YesYes8010
6x517x374.691YesNo5612
6x517x414.691YesNo5812
6x51Lig4.591YesYes5010
6x52Lig6.441NoYes7010
6x556x595.091YesNo5412
6x55Lig26.111YesYes5010
E3E371YesYes3322
7x38Lig10.150NoYes5010
5x28Lig1.830NoYes5010
5x285x311.630NoNo5212

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Single7W41PD1762527W41-BB2-PD176252
100.00Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
50.00Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
50.00Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
50.00Single8CU6LJ-45178CU6-A2A-LJ-4517
50.00Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
47.06Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
47.06Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRR-D1-Rotigotine-Gs/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
46.67Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
46.67Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
46.67Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
46.67Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
46.67Consensusa2a_off_alloOrthosteric Ligand6ZDR-A2A-HMS1413f12-Na 6GT3-A2A-Imaradenant-Na 8CU7-A2A-LJ-4517-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PubChem 92460631; psb36-Na 5MZJ-A2A-Theophylline-Na 5OLO-A2A-Tozadenant-Na 5OLH-A2A-Vipadenant-Na 5NM4-A2A-ZM241385-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5MZP-A2A-Caffeine-Na 8CIC-A2A-Etrumadenant-Na
44.44Single2YDVNECA2YDV-A2A-NECA
44.44Single4UHRCGS216804UHR-A2A-CGS21680
44.44Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
44.44Single5G53NECA5G53-A2A-NECA-Gs
44.44Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
44.44Single6J20Aprepitant6J20-NK1-Aprepitant
44.44Single6TQ7SB-3348676TQ7-OX1-SB-334867
44.44Single7JVPSKF839597JVP-D1-SKF83959-Gs/&β;1/&γ;2
44.44Consensusa2_onOrthosteric Liganda2a_on a2b_on
44.44Consensusadenosine_offOrthosteric Liganda1_off a2_off
44.44Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
44.44Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2
43.75Single2YDOAdenosine2YDO-A2A-Adenosine
43.75Single3UZCPubChem 1355666093UZC-A2A-PubChem 135566609
43.75Single5IU7Q274563465IU7-A2A-Q27456346-Na
43.75Single5JTBZM2413855JTB-A2A-ZM241385
43.75Single5K2BZM2413855K2B-A2A-ZM241385-Na
43.75Single6AQFZM2413856AQF-A2A-ZM241385
43.75Single6TPNHTL66416TPN-OX2-HTL6641
43.75Single6V9SGTPL114036V9S-OX1-GTPL11403
43.75Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
43.75Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
43.75Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/&β;1/&γ;2
42.86Single8G59TUG-8918G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
42.11Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
42.11Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
42.11Consensusopioid_offOrthosteric Ligandkop_off mop_off nop_off dop_off
42.11Consensuspeptide_offOrthosteric Ligandopioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
41.18Single3EMLZM2413853EML-A2A-ZM241385
41.18Single3NY8ICI 118-5513NY8-β2-ICI 118-551
41.18Single3NYA(S)-Alprenolol3NYA-β2-(S)-Alprenolol
41.18Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
41.18Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
41.18Single4EIYZM2413854EIY-A2A-ZM241385-Na
41.18Single4GBR(S)-Carazolol4GBR-β2-(S)-Carazolol
41.18Single5IU8Q274563475IU8-A2A-Q27456347-Na
41.18Single5K2AZM2413855K2A-A2A-ZM241385-Na
41.18Single5OLGZM2413855OLG-A2A-ZM241385-Na
41.18Single5VRAZM2413855VRA-A2A-ZM241385-Na
41.18Single6PS0(S)-Carazolol6PS0-β2-(S)-Carazolol
41.18Single6PS2(S)-Alprenolol6PS2-β2-(S)-Alprenolol
41.18Single6S0LZM2413856S0L-A2A-ZM241385
41.18Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
41.18Single7PYRPSB-21157PYR-A2A-PSB-2115
41.18Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
41.18Single8JJOAlprenolol8JJO-β2-Alprenolol
41.18Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
41.18Consensusa2_offOrthosteric Liganda2a_off
41.18Consensusa2a_offOrthosteric Ligand8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 5UIG-A2A-J3.651.884G 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-PubChem 168451710 5K2D-A2A-ZM241385
41.18Consensusadenosine_onOrthosteric Liganda1_on a2_on
41.18Consensusnucleotide_onOrthosteric Ligandadenosine_on
40.91Single6HLOAprepitant6HLO-NK1-Aprepitant
40.00Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
40.00Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
40.00Single6TP4ACT-4622066TP4-OX1-ACT-462206
40.00Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
40.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
40.00Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/&β;1/&γ;2
40.00Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/&β;1/&γ;2
40.00Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
40.00Consensusbeta1_off_alloOrthosteric Ligand4BVN-β1-Cyanopindolol-Na
40.00Consensusffa4_on_alloOrthosteric Ligand8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
40.00Consensusox1_off_alloOrthosteric Ligand6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na 6TO7-OX1-Suvorexant-Na
38.89Single2RH1(S)-Carazolol2RH1-β2-(S)-Carazolol
38.89Single2YCW(S)-Carazolol2YCW-β1-(S)-Carazolol
38.89Single5D6L(S)-Carazolol5D6L-β2-(S)-Carazolol
38.89Single5IUAQ274563485IUA-A2A-Q27456348-Na
38.89Single5N2RPubChem 92460631; psb365N2R-A2A-PubChem 92460631; psb36-Na
38.89Single5N2SPSB365N2S-A1-PSB36
38.89Single5NM2ZM2413855NM2-A2A-ZM241385-Na
38.89Single5WQCEMPA5WQC-OX2-EMPA
38.89Single5X7D(S)-Carazolol5X7D-β2-(S)-Carazolol-PubChem 129318963
38.89Single5XPRBosentan5XPR-ETB-Bosentan
38.89Single6GDGNECA6GDG-A2A-NECA-Gs/&β;1/&γ;1
38.89Single6LPLZM2413856LPL-A2A-ZM241385-Na
38.89Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
38.89Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
38.89Single6PS6Timolol6PS6-β2-Timolol
38.89Single6S0QZM2413856S0Q-A2A-ZM241385
38.89Single6WQAZM2413856WQA-A2A-ZM241385-Na
38.89Single7CKXA776367CKX-D1-A77636-Gs/&β;1/&γ;2
38.89Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
38.89Single7RM5ZM2413857RM5-A2A-ZM241385-Na
38.89Single7SINNPS-21437SIN-CaS-NPS-2143
38.89Single7SINNPS-21437SIN-CaS-NPS-2143
38.89Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
38.89Single8FYNZM2413858FYN-A2A-ZM241385-Na
38.89Single8GNEKW-63568GNE-A2A-KW-6356-Na
38.89Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
38.89Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
38.89Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
38.89Consensusa2a_onOrthosteric Ligand6GDG-A2A-NECA-Gs/&β;1/&γ;1
38.89Consensusadrenergic_offOrthosteric Ligandbeta_off alpha_off
38.89Consensusamine_offOrthosteric Ligandadrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
38.89Consensusbeta2_offOrthosteric Ligand6PS2-β2-(S)-Alprenolol 6PS3-β2-(S)-Carvedilol 6PS5-β2-(S)-Propranolol 6PS6-β2-Timolol 2RH1-β2-(S)-Carazolol 6PS4-β2-ICI 118-551 3NY9-β2-PubChem 913103
38.89Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
38.89Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
38.46Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
38.46Single8PWNTheophylline8PWN-A2A-Theophylline
38.10Single3NY9PubChem 9131033NY9-β2-PubChem 913103
38.10Single4UG2CGS216804UG2-A2A-CGS21680
38.10Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
38.10Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
37.50Single3VG9ZM2413853VG9-A2A-ZM241385-Antibody
37.50Single3VGAZM2413853VGA-A2A-ZM241385-Antibody
37.50Single4S0VSuvorexant4S0V-OX2-Suvorexant
37.50Single5K2DZM2413855K2D-A2A-ZM241385
37.50Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
37.50Single5WS3EMPA5WS3-OX2-EMPA
37.50Single6JZHZM2413856JZH-A2A-ZM241385-Na
37.50Single6NWEOctyl Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
37.50Single6PS7ZM2413856PS7-A2A-ZM241385-Na
37.50Single6TODEMPA6TOD-OX1-EMPA-Na
37.50Single6TPJSuvorexant6TPJ-OX2-Suvorexant
37.50Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
37.50Single7C61Ergotamine7C61-5-HT1B-Ergotamine
37.50Single7F8ULintitript7F8U-CCKA-Lintitript
37.50Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
37.50Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
37.50Single7XRRLemborexant7XRR-OX2-Lemborexant
37.50Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
37.50Single8GEDEpinephrine8GED-β2-Epinephrine-Gs/&β;1/&γ;2
37.50Single8GG9Epinephrine8GG9-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
37.50Single8GNGIstradefylline8GNG-A2A-Istradefylline
37.50Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
37.50Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/&β;1/&γ;2
37.50Single8UNLEpinephrine8UNL-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
37.50Single8UNTEpinephrine8UNT-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
37.50Single8UNUEpinephrine8UNU-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
37.50Single8UNWEpinephrine8UNW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
37.50Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
37.50Consensusalpha2_offOrthosteric Ligandalpha2a_off alpha2c_off
37.50Consensusgi_nucleotideOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
37.50Consensusorexin_offOrthosteric Ligandox2_off ox1_off
36.84Single3SN6BI1671073SN6-β2-BI167107-Gs/&β;1/&γ;2
36.84Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
36.84Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
36.84Single5D5A(S)-Carazolol5D5A-β2-(S)-Carazolol
36.84Single5D5B(S)-Carazolol5D5B-β2-(S)-Carazolol
36.84Single5X93K-87945X93-ETB-K-8794
36.84Single6E59L-7607356E59-NK1-L-760735
36.84Single6H7JIsoprenaline6H7J-β1-Isoprenaline
36.84Single6J21Aprepitant6J21-NK1-Aprepitant
36.84Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
36.84Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
36.84Single7CKYPW04647CKY-D1-PW0464-Gs/&β;1/&γ;2
36.84Single7EW7PubChem 40774607EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
36.84Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2
36.84Single7JV5SKF812977JV5-D1-SKF81297-Gs/&β;1/&γ;2
36.84Single7PX4PSB-21137PX4-A2A-PSB-2113
36.84Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
36.84Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2
36.84Single7W6PW967W6P-α2a-W96-Go/&β;1/&γ;2
36.84Single7W7EW587W7E-α2a-W58-Go/&β;1/&γ;2
36.84Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/&β;1/&γ;2
36.84Single8DZPmomSalB8DZP-κ-momSalB-Gi1/&β;1/&γ;2
36.84Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
36.84Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/&β;1/&γ;2
36.84Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
36.84Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
36.84Consensus5ht1b_onOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
36.84Consensus5ht_offOrthosteric Ligand5ht2_off 5ht5_off 5ht1_off
36.84Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
36.84Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
36.84Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCZ-β1-Iodocyanopindolol
36.84Consensusdopamine_offOrthosteric Ligandd3_off d2_off d4_off
36.84Consensusgi_amineOrthosteric Ligandgi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
36.84Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A2A-NECA-Gs/&β;1/&γ;1 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
36.84Consensusgs_compl-peptideOrthosteric Ligand8I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
36.84Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
36.84Consensusnk1_offOrthosteric Ligand6J20-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
36.36Single7F8XNN90567F8X-CCKA-NN9056
36.36Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
36.36Consensusmop_offOrthosteric Ligand7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
36.00Consensusbombesin_onOrthosteric Ligandbb2_on bb1_on
35.71Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
35.71Single8A2OTheophylline8A2O-A2A-Theophylline-Na
35.71Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
35.71Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
35.29Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
35.29Single4ZJCSB-6740424ZJC-OX1-SB-674042
35.29Single5IU4ZM2413855IU4-A2A-ZM241385-Na
35.29Single5IUBQ274563445IUB-A2A-Q27456344-Na
35.29Single5K2CZM2413855K2C-A2A-ZM241385-Na
35.29Single5NLXZM2413855NLX-A2A-ZM241385-Na
35.29Single5NM4ZM2413855NM4-A2A-ZM241385-Na
35.29Single5TE3Octyl Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
35.29Single5UVIZM2413855UVI-A2A-ZM241385
35.29Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
35.29Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
35.29Single6MH8ZM2413856MH8-A2A-ZM241385
35.29Single6PS4ICI 118-5516PS4-β2-ICI 118-551
35.29Single6PS5(S)-Propranolol6PS5-β2-(S)-Propranolol
35.29Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
35.29Single6TP3Nemorexant6TP3-OX1-Nemorexant
35.29Single6TPGEMPA6TPG-OX2-EMPA
35.29Single6TPKRetosiban6TPK-OT-Retosiban
35.29Single7AROLUF58337ARO-A2A-LUF5833-Na
35.29Single7JOZVFP7JOZ-D1-VFP-Gs/&β;1/&γ;2
35.29Single7T32ZM2413857T32-A2A-ZM241385
35.29Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
35.29Single8GEGEpinephrine8GEG-β2-Epinephrine-Gs/&β;1/&γ;2
35.29Single8GG3Epinephrine8GG3-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.29Single8GGKEpinephrine8GGK-β2-Epinephrine
35.29Single8GGMEpinephrine8GGM-β2-Epinephrine
35.29Single8GGPEpinephrine8GGP-β2-Epinephrine
35.29Single8GGQEpinephrine8GGQ-β2-Epinephrine
35.29Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
35.29Single8JLNT1AM8JLN-TA1-T1AM-Gs/&β;1/&γ;2
35.29Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
35.29Single8UHBRO52563908UHB-TA1-RO5256390-Gs/&β;1/&γ;2
35.29Single8UNREpinephrine8UNR-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.29Single8UNSEpinephrine8UNS-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.29Single8UNZEpinephrine8UNZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.29Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
35.29Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
35.29Consensusalpha2b_onOrthosteric Ligand6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
35.29Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
35.29Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
35.29Consensusox1_offOrthosteric Ligand6TOT-OX1-Lemborexant 6TP4-OX1-ACT-462206 6TP6-OX1-Filorexant 6V9S-OX1-GTPL11403 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ7-OX1-SB-334867 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant
35.29Consensusox2_offOrthosteric Ligand6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant
35.29Consensusvasopressin-ot_offOrthosteric Ligandot_off
35.00Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
35.00Single3D4STimolol Maleate3D4S-β2-Timolol Maleate
35.00Single4AMIBucindolol4AMI-β1-Bucindolol
35.00Single4LDEBI1671074LDE-β2-BI167107
35.00Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
35.00Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
35.00Single6HLPNetupitant6HLP-NK1-Netupitant
35.00Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
35.00Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
35.00Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
35.00Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
35.00Single7YITNalfurafine7YIT-κ-Nalfurafine
35.00Single8I95EP548I95-C3aB-EP54-Go/&β;1/&γ;2
35.00Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2
35.00Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2
35.00Single8JWYPubChem 1684517108JWY-A2A-PubChem 168451710
35.00Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
35.00Consensusleuko_offOrthosteric Ligandblt_off cyslt_off
35.00Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
34.78Single3QAKUK-4320973QAK-A2A-UK-432097
34.78Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
33.33Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
33.33Single2Y02Carmoterol2Y02-β1-Carmoterol
33.33Single2Y04Salbutamol2Y04-β1-Salbutamol
33.33Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
33.33Single3UZAGTPL92363UZA-A2A-GTPL9236
33.33Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
33.33Single5JQH(S)-Carazolol5JQH-β2-(S)-Carazolol
33.33Single5TGZAM65385TGZ-CB1-AM6538
33.33Single5UENDU1725UEN-A1-DU172
33.33Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
33.33Single5WF5UK-4320975WF5-A2A-UK-432097
33.33Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
33.33Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
33.33Single6LPJZM2413856LPJ-A2A-ZM241385-Na
33.33Single6LPKZM2413856LPK-A2A-ZM241385-Na
33.33Single6PRZ(S)-Alprenolol6PRZ-β2-(S)-Alprenolol
33.33Single6PS1Timolol6PS1-β2-Timolol
33.33Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
33.33Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
33.33Single7CRHSKF839597CRH-D1-SKF83959-Gs/&β;1/&γ;2
33.33Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
33.33Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
33.33Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
33.33Single7EZCUKA7EZC-A2A-UKA
33.33Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
33.33Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
33.33Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/&β;1/&γ;2
33.33Single7UL4Alvimopan7UL4-μ-Alvimopan
33.33Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
33.33Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/&β;1/&γ;2
33.33Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
33.33Single7WC7Lisuride7WC7-5-HT2A-Lisuride
33.33Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
33.33Single7XJISolabegron7XJI-β3-Solabegron-Gs/&β;1/&γ;2
33.33Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
33.33Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
33.33Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
33.33Single8GE3Epinephrine8GE3-β2-Epinephrine-Gs/&β;1/&γ;2
33.33Single8GEEEpinephrine8GEE-β2-Epinephrine-Gs/&β;1/&γ;2
33.33Single8GEHEpinephrine8GEH-β2-Epinephrine-Gs/&β;1/&γ;2
33.33Single8GFWEpinephrine8GFW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8GFXEpinephrine8GFX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8GFYEpinephrine8GFY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8GFZEpinephrine8GFZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8GG0Epinephrine8GG0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8GG1Epinephrine8GG1-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8GG2Epinephrine8GG2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8GG6Epinephrine8GG6-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8GGJEpinephrine8GGJ-β2-Epinephrine
33.33Single8GGNEpinephrine8GGN-β2-Epinephrine
33.33Single8GGOEpinephrine8GGO-β2-Epinephrine
33.33Single8GGUEpinephrine8GGU-β2-Epinephrine
33.33Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
33.33Single8J18(3R)-3-hydroxydodecanoic acid8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
33.33Single8J6QBeta-hydroxybutyrate8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
33.33Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
33.33Single8UNMEpinephrine8UNM-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8UNNEpinephrine8UNN-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8UNPEpinephrine8UNP-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
33.33Single8X63Mepyramine8X63-H1-Mepyramine
33.33Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
33.33Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
33.33Consensusadrenergic_onOrthosteric Ligandbeta_on alpha_on
33.33Consensusalpha2_onOrthosteric Ligandalpha2a_on alpha2b_on
33.33Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
33.33Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
33.33Consensusamine_onOrthosteric Ligandadrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on
33.33Consensuscck_offOrthosteric Ligandccka_off
33.33Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
33.33Consensusdopamine_onOrthosteric Ligandd3_on d2_on d5_on d1_on
33.33Consensusendothelin_offOrthosteric Ligandetb_off
33.33Consensusetb_offOrthosteric Ligand5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500 5X93-ETB-K-8794
33.33Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
33.33Consensustachykinin_offOrthosteric Ligandnk1_off
33.33Consensustar_onOrthosteric Ligandta1_on
32.00Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
31.82Single5WF6UK-4320975WF6-A2A-UK-432097
31.82Single5ZTYAM102575ZTY-CB2-AM10257
31.82Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
31.82Single7XY6PubChem 117178317XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
31.82Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2 8I95-C3aB-EP54-Go/&β;1/&γ;2
31.82Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
31.82Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
31.82Consensusgs_bombesinOrthosteric Ligand8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.82Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
31.82Consensuslpl_offOrthosteric Ligands1p_off lpa_off
31.58Single2Y03Isoprenaline2Y03-β1-Isoprenaline
31.58Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
31.58Single5TVNLSD5TVN-5-HT2B-LSD
31.58Single5ZK3Quinuclidinyl benzilate hydrobromide5ZK3-M2-Quinuclidinyl benzilate hydrobromide
31.58Single6E67BI1671076E67-β2-BI167107-Gs (fused)
31.58Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
31.58Single6PS3(S)-Carvedilol6PS3-β2-(S)-Carvedilol
31.58Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
31.58Single6TP6Filorexant6TP6-OX1-Filorexant
31.58Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
31.58Single7BVQ(S)-Carazolol7BVQ-β1-(S)-Carazolol
31.58Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
31.58Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2
31.58Single7XKAEpinephrine7XKA-β2-Epinephrine
31.58Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
31.58Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
31.58Single8ID9Eicosapentaenoic acid8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
31.58Single8QOTNanobody E8QOT-μ-Nanobody E
31.58Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
31.58Single8UNYEpinephrine8UNY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
31.58Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
31.58Consensusa1_on_alloOrthosteric Ligand7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
31.58Consensusalpha2a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
31.58Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
31.58Consensusbeta2_onOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
31.58Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
31.58Consensusgi_adrenergicOrthosteric Ligand7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
31.58Consensusgo_amineOrthosteric Ligandgo_adrenergic go_muscarinic go_5ht
31.58Consensusgs_adrenergicOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJI-β3-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
31.25Single3OE9IT1t3OE9-CXCR4-IT1t
31.25Single3PBLEticlopride3PBL-D3-Eticlopride
31.25Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
31.25Single6HLLCP999946HLL-NK1-CP99994
31.25Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
31.25Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2
31.25Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/&β;1/&γ;2
31.25Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
31.25Single8GGSEpinephrine8GGS-β2-Epinephrine
31.25Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
31.25Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
31.25Single8UNVEpinephrine8UNV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
31.25Single8UNXEpinephrine8UNX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
31.25Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
31.25Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/&β;1/&γ;2
31.25Consensus5ht4_onOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
31.25Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
30.77Single5MZPCaffeine5MZP-A2A-Caffeine-Na
30.77Single8WCBCyclohexylammonium ion8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.77Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
30.43Single4AMJ(S)-Carvedilol4AMJ-β1-(S)-Carvedilol
30.00Single3P0GBI1671073P0G-β2-BI167107
30.00Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
30.00Single3UONQuinuclidinyl benzilate hydrobromide3UON-M2-Quinuclidinyl benzilate hydrobromide
30.00Single4RWADIPP-NH24RWA-δ-DIPP-NH2
30.00Single6NI3BI1671076NI3-β2-BI167107-Gs/&β;1/&γ;2
30.00Single6WGTLSD6WGT-5-HT2A-LSD
30.00Single7B6WCyclazosin7B6W-α1b-Cyclazosin
30.00Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
30.00Single7TUYGSK682753A7TUY-GPR183-GSK682753A
30.00Single8E0GBU728E0G-μ-BU72
30.00Single8G056-OAU8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
30.00Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
30.00Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
30.00Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
30.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
30.00Consensus5ht5_offOrthosteric Ligand5ht5a_off
30.00Consensusalpha1b_offOrthosteric Ligand7B6W-α1b-Cyclazosin
30.00Consensuscck_onOrthosteric Ligandccka_on cckb_on
30.00Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
30.00Consensusgi_dopamineOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
30.00Consensusgi_ffaOrthosteric Ligand8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
30.00Consensusgo_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
30.00Consensush1_offOrthosteric Ligand3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole 8X63-H1-Mepyramine 8X64-H1-Desloratadine
30.00Consensushistamine_offOrthosteric Ligandh1_off
30.00Consensuslpa_offOrthosteric Ligandlpa1_off
30.00Consensussst4_onOrthosteric Ligand7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
29.63Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
29.63Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.63Consensusbb1_onOrthosteric Ligand8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.63Consensusgi_neuromedinOrthosteric Ligand7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
29.41Single2X72All-trans-retinal2X72-Rhodopsin-All-trans-retinal-Gt(CT)
29.41Single3PWHZM2413853PWH-A2A-ZM241385
29.41Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
29.41Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/&β;1/&γ;2
29.41Single6KUXRS-799486KUX-α2a-RS-79948
29.41Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
29.41Single6ME2Ramelteon6ME2-MT1-Ramelteon
29.41Single6OBA(S)-Alprenolol6OBA-β2-(S)-Alprenolol-GTPL11074
29.41Single6OYAAll-trans-retinal6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
29.41Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2
29.41Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
29.41Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
29.41Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
29.41Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
29.41Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2
29.41Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2
29.41Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2
29.41Single8GEAEpinephrine8GEA-β2-Epinephrine-Gs/&β;1/&γ;2
29.41Single8GECEpinephrine8GEC-β2-Epinephrine-Gs/&β;1/&γ;2
29.41Single8GEFEpinephrine8GEF-β2-Epinephrine-Gs/&β;1/&γ;2
29.41Single8GG7Epinephrine8GG7-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
29.41Single8GGAEpinephrine8GGA-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
29.41Single8GGVEpinephrine8GGV-β2-Epinephrine
29.41Single8GGXEpinephrine8GGX-β2-Epinephrine
29.41Single8GH0Epinephrine8GH0-β2-Epinephrine
29.41Single8IW4Spermidine8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2
29.41Single8IWESpermidine8IWE-TAAR9-Spermidine
29.41Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
29.41Single8UNOEpinephrine8UNO-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
29.41Single8UO0Epinephrine8UO0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
29.41Single8UO1Epinephrine8UO1-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
29.41Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
29.41Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
29.41Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
29.41Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
29.41Consensusalpha1_onOrthosteric Ligandalpha1a_on
29.41Consensusalpha1a_onOrthosteric Ligand7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
29.41Consensusalpha2a_offOrthosteric Ligand6KUX-α2a-RS-79948
29.41Consensusbeta2_off_alloOrthosteric Ligand6OBA-β2-(S)-Alprenolol-GTPL11074
29.41Consensusgt_class-aOrthosteric Ligandgt_opsin
29.41Consensusgt_opsinOrthosteric Ligandgt_sensory
29.41Consensusgt_sensoryOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
29.41Consensusmelatonin_onOrthosteric Ligandmt1_on mt2_on
29.41Consensusmglu_onOther Ligandmglu2_on mglu4_on
29.17Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
29.17Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
29.17Consensusalpha1_offOrthosteric Ligandalpha1a_off alpha1b_off
29.17Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
29.17Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
28.57Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
28.57Single6H7N(S)-Xamoterol6H7N-β1-(S)-Xamoterol
28.57Single6MXTSalmeterol6MXT-β2-Salmeterol
28.57Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
28.57Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
28.57Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
28.57Single7DFPSpiperone7DFP-D2-Spiperone
28.57Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/&β;1/&γ;2
28.57Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
28.57Single7K15MKD0467K15-BLT1-MKD046-Na
28.57Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
28.57Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
28.57Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
28.57Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
28.57Single7XMTJ-21567XMT-SST4-J-2156-Gi1/&β;1/&γ;2
28.57Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
28.57Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
28.57Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
28.57Single8JJ8Formoterol8JJ8-β2-Formoterol
28.57Single8JJLOlodaterol8JJL-β2-Olodaterol
28.57Single8JWZAB9288JWZ-A2A-AB928-Na
28.57Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
28.57Consensusblt1_offOrthosteric Ligand7K15-BLT1-MKD046-Na
28.57Consensusblt_offOrthosteric Ligandblt1_off
28.57Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
28.57Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
28.57Consensusgo_5htOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
28.57Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
28.00Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
27.78Single3REYPubChem 56973REY-A2A-PubChem 5697
27.78Single3RZECidoxepin3RZE-H1-Cidoxepin
27.78Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
27.78Single6A94Zotepine6A94-5-HT2A-Zotepine
27.78Single6IQLL7458706IQL-D4-L745870
27.78Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
27.78Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
27.78Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
27.78Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
27.78Single6ZDVPubChem 9840736ZDV-A2A-PubChem 984073-Na
27.78Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/&β;1/&γ;2
27.78Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
27.78Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
27.78Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
27.78Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
27.78Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2
27.78Single7F0TDopamine7F0T-D1-Dopamine-Gs/&β;1/&γ;2
27.78Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
27.78Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
27.78Single8GDZEpinephrine8GDZ-β2-Epinephrine-Gs/&β;1/&γ;2
27.78Single8GE1Epinephrine8GE1-β2-Epinephrine-Gs/&β;1/&γ;2
27.78Single8GE4Epinephrine8GE4-β2-Epinephrine-Gs/&β;1/&γ;2
27.78Single8GE6Epinephrine8GE6-β2-Epinephrine-Gs/&β;1/&γ;2
27.78Single8GE7Epinephrine8GE7-β2-Epinephrine-Gs/&β;1/&γ;2
27.78Single8GE8Epinephrine8GE8-β2-Epinephrine-Gs/&β;1/&γ;2
27.78Single8GE9Epinephrine8GE9-β2-Epinephrine-Gs/&β;1/&γ;2
27.78Single8GFVEpinephrine8GFV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
27.78Single8GG4Epinephrine8GG4-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
27.78Single8GG5Epinephrine8GG5-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
27.78Single8GG8Epinephrine8GG8-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
27.78Single8GGIEpinephrine8GGI-β2-Epinephrine
27.78Single8GGLEpinephrine8GGL-β2-Epinephrine
27.78Single8GGTEpinephrine8GGT-β2-Epinephrine
27.78Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
27.78Single8JERAcipimox8JER-HCA2-Acipimox-Go/&β;1/&γ;2
27.78Single8JIMMMF8JIM-HCA2-MMF-Gi1/&β;1/&γ;2
27.78Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2
27.78Single8K5CAcipimox8K5C-HCA2-Acipimox
27.78Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
27.78Single8UNQEpinephrine8UNQ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
27.78Single8UO2Epinephrine8UO2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
27.78Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
27.78Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6WH4-5-HT2A-Methiothepin 7VOE-5-HT2A-Aripiprazole 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 6A93-5-HT2A-Risperidone
27.78Consensus5ht2a_onOrthosteric Ligand7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
27.78Consensus5ht5_onOrthosteric Ligand5ht5a_on
27.78Consensus5ht5a_onOrthosteric Ligand7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
27.78Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
27.78Consensusd1_on_alloOrthosteric Ligand7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
27.78Consensusd3_onOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
27.78Consensusgi_melatoninOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
27.78Consensusgs_tarOrthosteric Ligand8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
27.78Consensushca_onOrthosteric Ligandhca2_on hca3_on
27.78Consensushcar_onOrthosteric Ligandhca_on
27.78Consensusm1_off_alloOrthosteric Ligand6WJC-M1-Atropine-Muscarinic toxin 7
27.78Consensussensory_offOrthosteric Ligandopsin_off
27.59Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
27.59Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
27.27Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
27.27Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
27.27Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
27.27Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
27.27Single6DDFDamgo6DDF-μ-Damgo-Gi1/&β;1/&γ;2
27.27Single6H7LDobutamine6H7L-β1-Dobutamine
27.27Single6IBLArformoterol6IBL-β1-Arformoterol
27.27Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2
27.27Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
27.27Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
27.27Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
27.27Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
27.27Single7UM4AS26747237UM4-5-HT5A-AS2674723
27.27Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
27.27Single7XZ6APD6687XZ6-GPR119-APD668-Gs/&β;1/&γ;2
27.27Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
27.27Single8E9YPubChem 4466038E9Y-M3-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
27.27Single8ID8TUG-8918ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
27.27Consensus5ht5a_offOrthosteric Ligand7UM4-5-HT5A-AS2674723
27.27Consensuscckb_onOrthosteric Ligand7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
27.27Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
27.27Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
26.92Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
26.92Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
26.92Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
26.92Consensusnmur_onOrthosteric Ligandnmur1_on nmur2_on
26.67Single3RFMCaffeine3RFM-A2A-Caffeine
26.67Single5GLHEndothelin-15GLH-ETB-Endothelin-1
26.67Single6IGKEndothelin-36IGK-ETB-Endothelin-3
26.67Single6OY9All-trans-retinal6OY9-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
26.67Single8WC5Tetramethylammonium ion8WC5-TA1-Tetramethylammonium ion-chim(NtGi1-Gs)/&β;1/&γ;2
26.67Consensushca2_on_alloOrthosteric Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
26.67Consensussensory_onOrthosteric Ligandopsin_on
26.32Single2Y01Dobutamine2Y01-β1-Dobutamine
26.32Single4DAJTiotropium4DAJ-M3-Tiotropium
26.32Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
26.32Single4EJ4Naltrindole4EJ4-δ-Naltrindole
26.32Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
26.32Single4MQSIperoxo4MQS-M2-Iperoxo
26.32Single4U14Tiotropium4U14-M3-Tiotropium
26.32Single4U16N-Methyl Scopolamine4U16-M3-N-Methyl Scopolamine
26.32Single4X1HNonyl Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
26.32Single4YAYZD-71554YAY-AT1-ZD-7155
26.32Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
26.32Single5UIGJ3.651.884G5UIG-A2A-J3.651.884G
26.32Single5YC8N-Methyl Scopolamine5YC8-M2-N-Methyl Scopolamine
26.32Single5ZK8N-Methyl Scopolamine5ZK8-M2-N-Methyl Scopolamine
26.32Single5ZKCN-Methyl Scopolamine5ZKC-M2-N-Methyl Scopolamine
26.32Single6DRXLisuride6DRX-5-HT2B-Lisuride
26.32Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
26.32Single6H7MSalbutamol6H7M-β1-Salbutamol
26.32Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
26.32Single6TOTLemborexant6TOT-OX1-Lemborexant
26.32Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.32Single7BU7BI1671077BU7-β1-BI167107
26.32Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
26.32Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
26.32Single7LJCPubChem 867641037LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
26.32Single7T2GMitragynine pseudoindoxyl7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
26.32Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
26.32Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2
26.32Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
26.32Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
26.32Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
26.32Single8GEBEpinephrine8GEB-β2-Epinephrine-Gs/&β;1/&γ;2
26.32Single8GGBEpinephrine8GGB-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
26.32Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/&β;1/&γ;2
26.32Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2
26.32Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
26.32Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2
26.32Single8JLZST19368JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
26.32Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
26.32Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
26.32Single8X64Desloratadine8X64-H1-Desloratadine
26.32Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
26.32Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
26.32Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
26.32Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
26.32Consensusgi_5htOrthosteric Ligand7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
26.32Consensusgi_hcaOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
26.32Consensusgi_hcarOrthosteric Ligandgi_hca
26.32Consensusgo_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
26.32Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
26.32Consensushca2_onOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
26.32Consensushistamine_onOrthosteric Ligandh1_on h4_on
26.32Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
26.32Consensusm4_on_alloOrthosteric Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
26.32Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
26.09Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
26.09Single6PT3DPI-2876PT3-δ-DPI-287
26.09Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
26.09Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.09Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
26.09Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.09Single8X5YAstemizole8X5Y-H1-Astemizole
26.09Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
26.09Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
26.09Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
26.09Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
26.09Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
25.93Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
25.93Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
25.93Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
25.93Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.93Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
25.93Consensusgs_melanocortinOrthosteric Ligand7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2
25.93Consensusgs_neuromedinOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.93Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
25.00Single2Y00Dobutamine2Y00-β1-Dobutamine
25.00Single3OE6IT1t3OE6-CXCR4-IT1t
25.00Single4IARErgotamine4IAR-5-HT1B-Ergotamine
25.00Single5C1MBU725C1M-μ-BU72
25.00Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
25.00Single5WKTOctyl Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
25.00Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
25.00Single6D26Fevipiprant6D26-DP2-Fevipiprant
25.00Single6DDEDamgo6DDE-μ-Damgo-Gi1/&β;1/&γ;2
25.00Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
25.00Single6LUQHaloperidol6LUQ-D2-Haloperidol
25.00Single6ME5Agomelatine6ME5-MT1-Agomelatine
25.00Single6ME9Ramelteon6ME9-MT2-Ramelteon
25.00Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
25.00Single7CFNINT-7777CFN-GPBA-INT-777-Gs/&β;1/&γ;2
25.00Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
25.00Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
25.00Single7MT8All-trans-retinal7MT8-Rhodopsin-All-trans-retinal-GRK1
25.00Single7MT9All-trans-retinal7MT9-Rhodopsin-All-trans-retinal-GRK1
25.00Single7MTAAll-trans-retinal7MTA-Rhodopsin-All-trans-retinal-GRK1
25.00Single7SBFPZM217SBF-μ-PZM21-Gi1/&β;1/&γ;2
25.00Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2
25.00Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
25.00Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
25.00Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
25.00Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single7WC6LSD7WC6-5-HT2A-LSD
25.00Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
25.00Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
25.00Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
25.00Single8DZQmomSalB8DZQ-κ-momSalB-Go/&β;1/&γ;2
25.00Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Single8EA0Iperoxo8EA0-M3-Iperoxo
25.00Single8GGREpinephrine8GGR-β2-Epinephrine
25.00Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
25.00Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/&β;1/&γ;2
25.00Single8J19PubChem 1270454228J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
25.00Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
25.00Single8POKHistamine8POK-H2-Histamine-Gs/&β;1/&γ;2
25.00Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
25.00Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide 6DRX-5-HT2B-Lisuride
25.00Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
25.00Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
25.00Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
25.00Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
25.00Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
25.00Consensusgo_opioidOrthosteric Ligand8DZQ-κ-momSalB-Go/&β;1/&γ;2
25.00Consensusgs_muscarinicOrthosteric Ligand8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
25.00Consensusm2_offOrthosteric Ligand5ZKB-M2-AF-DX 384 5ZKC-M2-N-Methyl Scopolamine 5ZK3-M2-Quinuclidinyl benzilate hydrobromide
25.00Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Consensusopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
25.00Consensussst_onOrthosteric Ligandsst2_on sst4_on
24.14Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
24.14Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
24.14Consensusendothelin_onOrthosteric Ligandetb_on eta_on
24.00Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
24.00Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/&β;1/&γ;2
24.00Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
24.00Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
24.00Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
24.00Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.81Single4DJHJDTic4DJH-κ-JDTic
23.81Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
23.81Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
23.81Single4U15Tiotropium4U15-M3-Tiotropium
23.81Single5V54Methiothepin5V54-5-HT1B-Methiothepin
23.81Single5XRAAM115425XRA-CB1-AM11542
23.81Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
23.81Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
23.81Single6OL9Tiotropium6OL9-M5-Tiotropium
23.81Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
23.81Single7EPENAM5637EPE-mGlu-NAM563
23.81Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
23.81Single7FEEPubMed 1048957FEE-CB1-PubMed 104895-ZCZ011
23.81Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
23.81Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
23.81Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
23.81Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
23.81Single7XOWGastrin7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
23.81Single7XOXCholecystokinin-87XOX-CCKB-Cholecystokinin-8-Gq/&β;1/&γ;2
23.81Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
23.81Single8EFLSR170188EFL-μ-SR17018-Gi1/&β;1/&γ;2
23.81Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2
23.81Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
23.81Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
23.81Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2
23.81Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2
23.81Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/&β;1/&γ;2
23.81Single8JD0J9R8JD0-mGlu2; mGlu3-Glutamate-J9R
23.81Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
23.81Single8JXVClozapine8JXV-H4-Clozapine-Gi1/&β;1/&γ;2
23.81Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
23.81Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
23.81Consensus5ht1_offOrthosteric Ligand5ht1b_off
23.81Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
23.81Consensuscyslt1_off_ortoalloOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
23.81Consensusffa4_onOrthosteric Ligand8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
23.81Consensusgs_ffaOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2 8GDB-EP4-PGE2-Gs/&β;1/&γ;2
23.81Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
23.81Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
23.81Consensuslpa_onOrthosteric Ligandlpa1_on
23.81Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl Scopolamine 5ZHP-M3-PubChem 134828589
23.81Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
23.81Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
23.81Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
23.81Consensusnpy_offOrthosteric Ligandnpy2_off npy1_off
23.81Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
23.53Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
23.53Single2G87All-trans-retinal2G87-Rhodopsin-All-trans-retinal
23.53Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
23.53Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
23.53Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
23.53Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
23.53Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
23.53Single7SRQLSD7SRQ-5-HT2B-LSD
23.53Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
23.53Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2
23.53Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.53Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.53Single8EF6Morphine8EF6-μ-Morphine-Gi1/&β;1/&γ;2
23.53Single8GEIEpinephrine8GEI-β2-Epinephrine-Gs/&β;1/&γ;2
23.53Single8GGYEpinephrine8GGY-β2-Epinephrine
23.53Single8GH1Epinephrine8GH1-β2-Epinephrine
23.53Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2
23.53Single8IJANiacin8IJA-HCA2-Niacin-Gi1/&β;1/&γ;2
23.53Single8ITFDMCHA8ITF-TAAR9-DMCHA-chim(NtGi1-Gs)/&β;1/&γ;2
23.53Single8IY9Niacin8IY9-HCA2-Niacin-Go/&β;1/&γ;2
23.53Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
23.53Single8K5BNiacin8K5B-HCA2-Niacin
23.53Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
23.53Consensusmt1_onOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
23.33Single6IGLIRL16206IGL-ETB-IRL1620
23.33Consensusgs_endothelinOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.33Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
23.08Single3OE0CVX153OE0-CXCR4-CVX15
23.08Single6PT2KGCHM076PT2-δ-KGCHM07
23.08Single6W25SHU91196W25-MC4-SHU9119-Ca
23.08Single7F4DAlpha-MSH7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
23.08Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
23.08Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1
23.08Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
23.08Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
23.08Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
23.08Consensusgi_formylpeptideOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
23.08Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
23.08Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
22.73Single5CXVTiotropium5CXV-M1-Tiotropium
22.73Single6A93Risperidone6A93-5-HT2A-Risperidone
22.73Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
22.73Single6CM4Risperidone6CM4-D2-Risperidone
22.73Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
22.73Single6KQIPubMed 1048956KQI-CB1-PubMed 104895-ORG27569
22.73Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
22.73Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
22.73Single6ZG4HTL00099366ZG4-M1-HTL0009936
22.73Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/&β;1/&γ;2
22.73Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2
22.73Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
22.73Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.73Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.73Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
22.73Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
22.73Single7WCNAR2314537WCN-GPR119-AR231453-Gs/&β;1/&γ;2
22.73Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
22.73Single7Y24Octreotide7Y24-SST2-Octreotide-Go/&β;1/&γ;2
22.73Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
22.73Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.73Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2
22.73Single8IJDMK68928IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
22.73Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
22.73Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
22.73Single8WU1KCA8WU1-CB1-KCA-Arrestin1
22.73Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg3_on
22.73Consensusat2_offOrthosteric Ligand7JNI-AT2-Olodanrigan
22.73Consensusbeta1_onOrthosteric Ligand7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
22.73Consensuscb1_off_alloOrthosteric Ligand6KQI-CB1-PubMed 104895-ORG27569
22.73Consensusclass-b2_onOrthosteric Ligandadgrg_on
22.73Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
22.73Consensusdp_offOrthosteric Liganddp2_off
22.73Consensusgi_class-fOther Ligandgi_frizzled
22.73Consensusgi_frizzledOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
22.73Consensusgpr119_onOrthosteric Ligand7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
22.73Consensusgs_trhOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
22.73Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
22.73Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
22.73Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
22.58Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
22.58Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
22.58Consensusgs_crfOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
22.22Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
22.22Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
22.22Single3ODUIT1t3ODU-CXCR4-IT1t
22.22Single6AKXA4R6AKX-CCR5-A4R
22.22Single6B73PubChem 1319551386B73-κ-PubChem 131955138
22.22Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
22.22Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2
22.22Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/&β;1/&γ;2
22.22Single7F8YDevazepide7F8Y-CCKA-Devazepide
22.22Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;1
22.22Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.22Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
22.22Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
22.22Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
22.22Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
22.22Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
22.22Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
22.22Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
22.22Single8EFOPZM218EFO-μ-PZM21-Gi1/&β;1/&γ;2
22.22Single8GGFEpinephrine8GGF-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.22Single8GGWEpinephrine8GGW-β2-Epinephrine
22.22Single8HOCImetit8HOC-H4-Imetit-Gi1/&β;1/&γ;2
22.22Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2
22.22Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
22.22Single8UO3Epinephrine8UO3-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
22.22Consensus5ht2_onOrthosteric Ligand5ht2a_on 5ht2c_on
22.22Consensusgi_histamineOrthosteric Ligand8HN8-H4-Histamine-Gi1/&β;1/&γ;2 8HOC-H4-Imetit-Gi1/&β;1/&γ;2
22.22Consensusgi_somatostatinOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
22.22Consensusgs_5htOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2 7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2 7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.22Consensusgs_histamineOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.22Consensush4_onOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.22Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
22.22Consensusnmur2_onOrthosteric Ligand7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.22Consensusopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
21.88Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
21.88Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
21.88Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
21.74Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
21.74Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
21.74Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
21.74Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.74Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
21.74Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
21.74Single7XK2MK68927XK2-HCA2-MK6892-Gi1/&β;1/&γ;2
21.74Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
21.74Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/&β;1/&γ;2
21.74Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.74Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.74Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
21.74Single8WRZ8D08WRZ-CB1-8D0-Arrestin1
21.74Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
21.74Consensusc5a1_off_ortoalloOrthosteric Ligand6C1Q-C5a1-PMX53-NDT9513727 6C1R-C5a1-PMX53-Avacopan; Na
21.74Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
21.74Consensusgs_orexinOrthosteric Ligand7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
21.74Consensusorexin_onOrthosteric Ligandox2_on
21.74Consensusot_onOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
21.43Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.43Single7KH0Acyclovir triphosphate7KH0-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
21.43Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
21.43Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
21.43Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
21.43Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
21.43Single8WCCCyclohexylammonium ion8WCC-TA1-Cyclohexylammonium ion
21.43Consensusgs_bradykininOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.05Single4DKLBeta-funaltrexamine4DKL-μ-Beta-funaltrexamine
21.05Single4MBSMaraviroc4MBS-CCR5-Maraviroc
21.05Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
21.05Single6DS0Ly2660976DS0-5-HT2B-Ly266097
21.05Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
21.05Single6ZG9GSK10347026ZG9-M1-GSK1034702
21.05Single7CMVPD1289077CMV-D3-PD128907-Gi1/&β;1/&γ;2
21.05Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
21.05Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/&β;1/&γ;2
21.05Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
21.05Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
21.05Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2
21.05Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
21.05Single7VODCariprazine7VOD-5-HT2A-Cariprazine
21.05Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
21.05Single7XOVSR1461317XOV-CCKA-SR146131-Gs/&β;1/&γ;2
21.05Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
21.05Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.05Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
21.05Single8GURPubChem 1048958GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2
21.05Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2
21.05Single8JHNMMF8JHN-HCA2-MMF-Go/&β;1/&γ;2
21.05Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
21.05Consensusdop_off_alloOrthosteric Ligand4N6H-δ-Naltrindole-Na
21.05Consensusffa2_onOrthosteric Ligand8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
21.05Consensush3_on_alloOrthosteric Ligand7F61-H3-PF-03654746-Cholesterol
21.05Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
20.83Single5EE7MK08935EE7-Glucagon-MK0893
20.83Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
20.83Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.83Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.83Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
20.83Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
20.83Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
20.83Single7SK9CCX6627SK9-ACKR3-CCX662
20.83Single7XN9L-054,5227XN9-SST2-L-054,522
20.83Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
20.83Single8XZFWN5618XZF-Apelin-WN561-Gi1/&β;1/&γ;2
20.83Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
20.83Consensusgo_vasopressinOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
20.83Consensuslpl_onOrthosteric Ligands1p_on lpa_on
20.83Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.83Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
20.69Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
20.69Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
20.69Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
20.69Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
20.59Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
20.00Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
20.00Single3PXOAll-trans-retinal3PXO-Rhodopsin-All-trans-retinal
20.00Single4QKXPubChem 762106284QKX-β2-PubChem 76210628
20.00Single4XT1Fractalkine4XT1-US28-Fractalkine
20.00Single5DHGPubChem 250014125DHG-NOP-PubChem 25001412
20.00Single5DSGTiotropium5DSG-M4-Tiotropium
20.00Single5DYSAll-trans-retinal5DYS-Rhodopsin-All-trans-retinal
20.00Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
20.00Single6D27CAY104716D27-DP2-CAY10471
20.00Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
20.00Single6IIVDaltroban6IIV-TP-Daltroban
20.00Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
20.00Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
20.00Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
20.00Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
20.00Single7F83PF-051904577F83-Ghrelin-PF-05190457
20.00Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
20.00Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
20.00Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
20.00Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
20.00Single7V3ZPubMed 1048957V3Z-CB1-PubMed 104895
20.00Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
20.00Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
20.00Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
20.00Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
20.00Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
20.00Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
20.00Single8EFQDamgo8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
20.00Single8EJCTAK-8758EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
20.00Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
20.00Single8GEJEpinephrine8GEJ-β2-Epinephrine-Gs/&β;1/&γ;2
20.00Single8GHVPubChem 1459649038GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
20.00Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/&β;1/&γ;2
20.00Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
20.00Single8J6RMK68928J6R-HCA2-MK6892-Gi1/&β;1/&γ;2
20.00Single8K5DGSK2560738K5D-HCA2-GSK256073
20.00Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
20.00Single8UO4Epinephrine8UO4-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
20.00Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Consensus5ht1a_onOrthosteric Ligand8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
20.00Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
20.00Consensusetb_onOrthosteric Ligand8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
20.00Consensusffa_onOrthosteric Ligandffa4_on ffa1_on ffa2_on ffa3_on
20.00Consensusfpr-alx_onOrthosteric Ligandfpr1-alx_on fpr2-alx_on
20.00Consensusfsh_on_alloOther Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
20.00Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
20.00Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
20.00Consensusgo_class-b1Orthosteric Ligandgo_crf
20.00Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
20.00Consensushca3_onOrthosteric Ligand8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
20.00Consensusm2_on_alloOrthosteric Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
20.00Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
20.00Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
20.00Consensusnmur1_onOrthosteric Ligand7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
20.00Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
20.00Consensustp_offOrthosteric Ligand6IIV-TP-Daltroban 6IIU-TP-Ramatroban
19.35Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
19.35Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
19.35Single7VGXNeuropeptide Y7VGX-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
19.35Single8FEGPRD_0025178FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
19.35Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
19.35Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
19.35Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
19.23Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
19.23Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
19.23Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
19.23Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
19.23Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
19.23Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.23Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
19.23Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
19.23Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
19.05Single4PHUFasiglifam4PHU-FFA1 (GPR40)-Fasiglifam
19.05Single5CGCHTL142425CGC-mGlu5-HTL14242
19.05Single5WIUNemonapride5WIU-D4-Nemonapride
19.05Single5WIVNemonapride5WIV-D4-Nemonapride-Na
19.05Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
19.05Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
19.05Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
19.05Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
19.05Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
19.05Single7C4SS1P7C4S-S1P3-S1P
19.05Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
19.05Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
19.05Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
19.05Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
19.05Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
19.05Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
19.05Single7Y27Somatostatin-147Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
19.05Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
19.05Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
19.05Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
19.05Single7YXAONO-54306087YXA-S1P5-ONO-5430608
19.05Single8FN1Neurotensin/neuromedin N8FN1-NTS1-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
19.05Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2
19.05Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
19.05Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
19.05Consensuscb2_onOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
19.05Consensusd4_offOrthosteric Ligand5WIU-D4-Nemonapride
19.05Consensusd4_off_alloOrthosteric Ligand5WIV-D4-Nemonapride-Na
19.05Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
19.05Consensusgs_sstOrthosteric Ligand7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
19.05Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
19.05Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
18.75Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
18.75Single7MTBAll-trans-retinal7MTB-Rhodopsin-All-trans-retinal-GRK1
18.75Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
18.75Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.52Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
18.52Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
18.52Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.52Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
18.52Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
18.52Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;2
18.52Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
18.52Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
18.52Consensusangiotensin_onOrthosteric Ligandat1_on
18.52Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
18.52Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
18.52Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.52Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.52Consensusmc5_onOrthosteric Ligand8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
18.52Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
18.18Single5TZR-5TZR-FFA1 (GPR40)-MK8666
18.18Single5XR8AM8415XR8-CB1-AM841
18.18Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
18.18Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
18.18Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
18.18Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2
18.18Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2
18.18Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
18.18Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2
18.18Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
18.18Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
18.18Single7WV9PubMed 1048957WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
18.18Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2
18.18Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
18.18Single8GUSHU-3088GUS-CB2-HU-308-Gi1/&β;1/&γ;2
18.18Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
18.18Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
18.18Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
18.18Single8JXWVUF68848JXW-H4-VUF6884-Gi1/&β;1/&γ;2
18.18Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/&β;1/&γ;2
18.18Consensusangiotensin_offOrthosteric Ligandat1_off at2_off
18.18Consensusgi_muscarinicOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
18.18Consensusrelaxin_onOrthosteric Ligandrxfp4_on
18.18Consensuss1p2_onOrthosteric Ligand7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
18.18Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
17.86Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
17.86Single6JODAngiotensin II6JOD-AT2-Angiotensin II
17.86Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
17.86Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
17.86Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
17.86Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
17.86Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.86Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
17.86Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
17.86Single8IHFMK68928IHF-HCA2-MK6892-Gi1/&β;1/&γ;2
17.86Single8J6IMK68928J6I-HCA2-MK6892-Gi1/&β;1/&γ;2
17.86Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
17.86Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
17.86Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
17.86Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
17.86Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
17.86Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
17.65Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
17.65Single3OE8IT1t3OE8-CXCR4-IT1t
17.65Single3PQRAll-trans-retinal3PQR-Rhodopsin-All-trans-retinal-Gt(CT)
17.65Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
17.65Single6FUFAll-trans-retinal6FUF-Rhodopsin-All-trans-retinal-Go/&β;1/&γ;2
17.65Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/&β;1/&γ;2
17.65Single7WC5Psilocin7WC5-5-HT2A-Psilocin
17.65Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.65Single8GGZEpinephrine8GGZ-β2-Epinephrine
17.65Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/&β;1/&γ;2
17.50Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
17.39Single4N4WSANT-14N4W-SMO-SANT-1
17.39Single4XEENeurotensin4XEE-NTS1-Neurotensin
17.39Single4XESNeurotensin4XES-NTS1-Neurotensin
17.39Single5X33BIIL2605X33-BLT1-BIIL260
17.39Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
17.39Single6IIURamatroban6IIU-TP-Ramatroban
17.39Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/&β;1/γ1
17.39Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
17.39Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
17.39Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
17.39Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
17.39Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
17.39Single7Y66BM2137Y66-C5a1-BM213-Gi1/&β;1/&γ;2
17.39Single8IBUErythromycin A8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.39Single8J6DEP1418J6D-C3aB-EP141-Go/&β;1/&γ;2
17.39Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/&β;1/&γ;2
17.39Consensuscannabinoid_onOrthosteric Ligandcb1_on cb2_on
17.39Consensuscb1_onOrthosteric Ligand8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
17.39Consensusgi_cannabinoidOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
17.39Consensusgs_bileacidOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
17.39Consensusgs_steroidOrthosteric Ligandgs_bileacid
17.39Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
17.39Consensustsh_on_alloOther Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
17.24Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
17.24Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
17.24Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
17.24Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
17.24Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
17.24Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.24Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
17.24Consensusbk1_onOrthosteric Ligand7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.24Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.24Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.14Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
17.14Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
17.14Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
17.14Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
16.67Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
16.67Single3AYMAll-trans-retinal3AYM-Rhodopsin-All-trans-retinal
16.67Single4BUONeurotensin4BUO-NTS1-Neurotensin
16.67Single4XT3Fractalkine4XT3-US28-Fractalkine
16.67Single5CGDHTL142425CGD-mGlu5-HTL14242
16.67Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
16.67Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
16.67Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
16.67Single6K1QIRL25006K1Q-ETB-IRL2500
16.67Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
16.67Single6QNOAll-trans-retinal6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
16.67Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
16.67Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
16.67Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2
16.67Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
16.67Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
16.67Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
16.67Single7SK3CXCL127SK3-ACKR3-CXCL12
16.67Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
16.67Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
16.67Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Single8GAGYVF8GAG-CB1-YVF-Gi1/&β;1/&γ;2
16.67Single8GGCEpinephrine8GGC-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
16.67Single8GGEEpinephrine8GGE-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
16.67Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/&β;1/&γ;2
16.67Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
16.67Single8HN8Histamine8HN8-H4-Histamine-Gi1/&β;1/&γ;2
16.67Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2
16.67Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
16.67Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
16.67Single8X2K5YM8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Consensusbileacid_onOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
16.67Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
16.67Consensusfpa_onOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Consensusgo_adhesionOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
16.67Consensusgo_class-b2Orthosteric Ligandgo_adhesion
16.67Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
16.67Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
16.67Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
16.67Consensusmt2_onOrthosteric Ligand7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
16.67Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
16.67Consensussteroid_onOrthosteric Ligandbileacid_on
16.13Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
16.13Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.13Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
16.13Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
16.13Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
16.13Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
16.00Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
16.00Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.00Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
16.00Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
16.00Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.00Single8IYHMK68928IYH-HCA2-MK6892-Go/&β;1/&γ;2
16.00Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
16.00Consensusfpr2-alx_onOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
16.00Consensusgs_adgrOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
16.00Consensusgs_class-b2Orthosteric Ligandgs_adgr
16.00Consensusmotilin_onOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.00Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
15.79Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
15.79Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
15.79Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
15.79Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
15.79Single5DHHSB-6121115DHH-NOP-SB-612111
15.79Single5U09Taranabant5U09-CB1-Taranabant
15.79Single5ZKQABT-4915ZKQ-PAF-ABT-491
15.79Single6AKYMaraviroc6AKY-CCR5-Maraviroc
15.79Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
15.79Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
15.79Single7BR3Elagolix7BR3-GnRH1-Elagolix
15.79Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
15.79Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
15.79Single7TUZ7alpha,25-dihydroxycholesterol7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
15.79Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
15.79Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
15.79Single7W0OElabela7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
15.79Single8A6CAll-trans-retinal8A6C-Rhodopsin-All-trans-retinal
15.79Single8A6DAll-trans-retinal8A6D-Rhodopsin-All-trans-retinal
15.79Single8A6EAll-trans-retinal8A6E-Rhodopsin-All-trans-retinal
15.79Single8IHKAcifran8IHK-HCA3-Acifran
15.79Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/&β;1/&γ;2
15.79Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.79Consensus5ht2c_onOrthosteric Ligand8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.79Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
15.62Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
15.62Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
15.62Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
15.62Single8IY6Endothelin-18IY6-ETB-Endothelin-1
15.62Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
15.38Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
15.38Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
15.38Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/&β;1/&γ;1
15.38Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
15.38Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
15.38Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
15.38Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
15.38Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
15.38Consensussst2_onOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
15.00Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
15.00Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
15.00Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
15.00Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
15.00Single6VI4JDTic6VI4-κ-JDTic
15.00Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
15.00Single7BB6Acyclovir triphosphate7BB6-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
15.00Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.00Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
15.00Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
15.00Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
15.00Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
15.00Single8GCML9026888GCM-EP4-L902688-Gi1/&β;1/&γ;2
15.00Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2
15.00Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.00Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.00Single8HQN9(S)-HODE8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
15.00Single8T3VDHA8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.00Consensusgnrh_offOrthosteric Ligandgnrh1_off
15.00Consensuslh_on_alloOther Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
15.00Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
15.00Consensuss1p_offOrthosteric Ligands1p1_off
14.81Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
14.81Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
14.81Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
14.81Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
14.81Single7SK5CXCL127SK5-ACKR3-CXCL12
14.81Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
14.81Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.81Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
14.81Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
14.81Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
14.81Consensuscx3cr_onOrthosteric Ligandcx3cr1_on
14.71Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
14.71Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
14.29Single4QIMPubChem 249053754QIM-SMO-PubChem 24905375
14.29Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
14.29Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
14.29Single6GPSMK08126GPS-CCR2-MK0812
14.29Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2
14.29Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
14.29Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
14.29Single7CFMP3957CFM-GPBA-P395-Gs/&β;1/&γ;2
14.29Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
14.29Single7SCGFH2107SCG-μ-FH210-Gi1/&β;1/&γ;2
14.29Single7VKTLTB47VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
14.29Single7XNACYN1548067XNA-SST2-CYN154806
14.29Single8EJKTAK-8758EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
14.29Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/&β;1/&γ;2
14.29Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-alpha-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
14.29Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
14.29Consensusblt_onOrthosteric Ligandblt1_on
14.29Consensuscb1_on_alloOrthosteric Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
14.29Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
14.29Consensuscx3cr1_onOrthosteric Ligand7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
14.29Consensusffa1_onOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.29Consensusgi_chemerinOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
14.29Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
14.29Consensushcar_offOrthosteric Ligandsuccinate_off
14.29Consensusleuko_onOrthosteric Ligandblt_on
14.29Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
14.29Consensusprostanoid_offOrthosteric Ligandep_off tp_off dp_off
14.29Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
14.29Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
13.89Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
13.89Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
13.79Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
13.79Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
13.79Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
13.79Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
13.79Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
13.64Single4WW3All-trans-retinal4WW3-Rhodopsin-All-trans-retinal
13.64Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
13.64Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
13.64Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
13.64Single6GPXMK08126GPX-CCR2-MK0812
13.64Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
13.64Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
13.64Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
13.64Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
13.64Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
13.64Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2
13.64Single8GDCPGE28GDC-EP3-PGE2-Gi1/&β;1/&γ;2
13.64Single8JPCNeurotensin 8-138JPC-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
13.64Consensusccr2_off_alloOther Ligand5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
13.64Consensusep3_onOrthosteric Ligand8GDC-EP3-PGE2-Gi1/&β;1/&γ;2
13.64Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
13.64Consensusep_offOrthosteric Ligandep4_off
13.51Consensuspth_onOrthosteric Ligandpth1_on pth2_on
13.33Single4A4MAll-trans-retinal4A4M-Rhodopsin-All-trans-retinal-Gt(CT)
13.33Single5EN0All-trans-retinal5EN0-Rhodopsin-All-trans-retinal-Gt(CT)
13.33Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
13.33Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
13.33Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
13.33Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
13.04Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
13.04Single4BV0Neurotensin4BV0-NTS1-Neurotensin
13.04Single5V56TC1145V56-SMO-TC114
13.04Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
13.04Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1
13.04Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/&β;1/&γ;1
13.04Single7P2L4YI7P2L-mGlu5-4YI
13.04Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
13.04Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.04Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.04Single7XTQR3997XTQ-GPBA-R399-Gs/&β;1/&γ;2
13.04Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.04Single8FMZNeurotensin/neuromedin N8FMZ-NTS1-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.04Single8X79MRE-2698X79-I2-MRE-269-Gs/&β;1/&γ;2
13.04Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
13.04Consensuschemerin_onOrthosteric Ligandcml1_on
13.04Consensuscml1_onOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
13.04Consensusnts1_on_alloOrthosteric Ligand8JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
12.90Single6FJ3PTH6FJ3-PTH1-PTH
12.90Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/&β;1/&γ;2
12.90Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
12.90Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
12.90Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
12.90Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
12.90Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
12.90Consensusclass-d_onOrthosteric Ligandste2_on
12.90Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
12.82Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
12.82Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
12.50Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
12.50Single4GRVNeurotensin 8-134GRV-NTS1-Neurotensin 8-13
12.50Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
12.50Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
12.50Single6OS2TRV0266OS2-AT1-TRV026
12.50Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/&β;1/&γ;2
12.50Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
12.50Single6YVRNTS8-136YVR-NTS1-NTS8-13
12.50Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
12.50Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
12.50Single7WC4Serotonin7WC4-5-HT2A-Serotonin
12.50Single7XKEBetahydroxyandrosterone7XKE-ADGRG2-Betahydroxyandrosterone-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.50Single8GCPPGE28GCP-EP4-PGE2-Gi1/&β;1/&γ;2
12.50Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/&β;1/&γ;2
12.50Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50Single8JPBNeurotensin 8-138JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
12.50Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
12.50Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
12.50Consensuschemokine_offOrthosteric Ligandcxcr_off
12.50Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II
12.50Consensuscxcr_offOrthosteric Ligandcxcr4_off
12.50Consensusgabab_offOther Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
12.50Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
12.50Consensusgi_class-dOrthosteric Ligandgi_ste
12.50Consensusgi_prostanoidOrthosteric Ligand8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GDC-EP3-PGE2-Gi1/&β;1/&γ;2 8GCM-EP4-L902688-Gi1/&β;1/&γ;2
12.50Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
12.50Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
12.50Consensusnts1_offOrthosteric Ligand6Z4Q-NTS1-SR142948A 6Z4S-NTS1-SR48692
12.50Consensusnts_offOrthosteric Ligandnts1_off
12.50Consensusprostanoid_onOrthosteric Ligandep_on fpa_on
12.12Single6LMLGlucagon6LML-Glucagon-Glucagon
12.12Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
12.12Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
12.12Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
12.12Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
12.12Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
12.12Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
12.00Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
12.00Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
12.00Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
12.00Consensusep4_onOrthosteric Ligand7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2
12.00Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.00Consensusgi_neurotensinOrthosteric Ligand7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
12.00Consensusgs_galaninOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.00Consensusgs_lipidOrthosteric Ligandgs_ffa gs_prostanoid
12.00Consensusgs_prostanoidOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.00Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.90Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
11.76Single2HPYAll-trans-retinal2HPY-Rhodopsin-All-trans-retinal
11.76Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
11.76Single6TQ9SB-4081246TQ9-OX1-SB-408124
11.76Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
11.76Single7VDMSubstance P7VDM-MRGPRX2-Substance P-Gi1/&β;1/&γ;2
11.76Single7XKDBetahydroxyandrosterone7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
11.76Single7Y14Beta-alanine7Y14-MRGPRD-Beta-alanine
11.76Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/&β;1/&γ;2
11.76Single8IWM2-Phenylethylamine8IWM-TAAR9-2-Phenylethylamine
11.54Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
11.54Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
11.54Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
11.54Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
11.54Single8INRAlpha-MSH8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
11.54Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.54Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
11.54Consensusclass-d_offOrthosteric Ligandste2_off
11.54Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
11.43Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
11.43Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
11.43Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
11.43Consensusglp_onOrthosteric Ligandglp1_on glp2_on
11.11Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
11.11Single6LI0GTPL98046LI0-GPR52-GTPL9804
11.11Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
11.11Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2
11.11Single7QA8Peptide7QA8-STE2-Peptide
11.11Single7QA8Peptide7QA8-STE2-Peptide
11.11Single7S8O(R)-Zinc-35737S8O-MRGPRX2-(R)-Zinc-3573-Gi1/&β;1/&γ;2
11.11Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
11.11Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
11.11Single7Y12Beta-alanine7Y12-MRGPRD-Beta-alanine-Gi1/&β;1/&γ;2
11.11Single8EITDoconexent8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
11.11Single8F76-8F76-OR51E2-Gs/&β;1/&γ;2
11.11Single8IW72-Phenylethylamine8IW7-TAAR9-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
11.11Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
11.11Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
11.11Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
11.11Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/&β;1/&γ;2
11.11Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
11.11Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
11.11Consensusclass-d_offOrthosteric Ligandste2_off
11.11Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
11.11Consensusgip_on_alloOther Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
11.11Consensussmo_off_alloOrthosteric Ligand6D32-SMO-Cyclopamine-Cyclopamine
11.11Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
10.81Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
10.71Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
10.71Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
10.71Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
10.71Consensussst_offOrthosteric Ligandsst2_off
10.53Single5L7IVismodegib5L7I-SMO-Vismodegib
10.53Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
10.53Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
10.53Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
10.53Single7S8N(R)-Zinc-35737S8N-MRGPRX2-(R)-Zinc-3573-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.53Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
10.53Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
10.53Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
10.53Single8JILNiacin8JIL-HCA2-Niacin-Gi1/&β;1/&γ;2
10.53Consensusclass-t_onOrthosteric Ligandtaste2_on
10.53Consensusgs_class-tOrthosteric Ligandgs_taste
10.53Consensusgs_tasteOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
10.53Consensussmo_on_alloOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
10.53Consensustaste2_onOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
10.00Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
10.00Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
10.00Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
10.00Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
10.00Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
10.00Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
10.00Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
10.00Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
10.00Single8DWHCompound-168DWH-MRGPRX1-Compound-16-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.00Single8FN0Neurotensin/neuromedin N8FN0-NTS1-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
10.00Single8HMPPubChem 699214798HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
10.00Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
10.00Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
10.00Single8U8FPML8U8F-GPR3-PML-Gs/&β;1/&γ;2
10.00Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
10.00Consensusclass-d_onOrthosteric Ligandste2_on
10.00Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
10.00Consensusffa3_on_alloOrthosteric Ligand8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
10.00Consensusgi_class-dOrthosteric Ligandgi_ste
10.00Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
10.00Consensusm2_on_alloOther Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
10.00Consensusp2y_offOrthosteric Ligandp2y1_off p2y12_off
10.00Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
10.00Consensussmo_on_alloOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
9.76Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
9.68Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
9.68Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
9.68Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
9.68Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
9.68Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
9.68Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
9.68Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
9.52Single6FFIMMPEP6FFI-mGlu5-MMPEP
9.52Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
9.52Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
9.52Single6ZINSR486926ZIN-NTS1-SR48692
9.52Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
9.52Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
9.52Single7VV6C48/807VV6-MRGPRX2-C48/80
9.52Single7VVOPTH7VVO-PTH1-PTH-Gs/&β;1/&γ;2
9.52Single7XJJGalanin7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
9.52Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
9.52Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.52Single8K2WAMG4878K2W-CXCR3-AMG487
9.52Single8K4NVF08K4N-GPR34-VF0-Gi1/&β;1/&γ;2
9.52Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
9.52Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/&β;1/&γ;2
9.52Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
9.52Consensuscxcr_onOrthosteric Ligandcxcr1_on cxcr2_on
9.52Consensusgo_galaninOrthosteric Ligand7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
9.52Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
9.52Consensusm1_off_alloOther Ligand6WJC-M1-Atropine-Muscarinic toxin 7
9.38Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
9.38Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
9.38Single7D3SSecretin7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
9.38Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
9.38Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
9.38Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
9.38Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
9.38Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
9.38Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
9.38Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
9.09Single5T04Neurotensin5T04-NTS1-Neurotensin
9.09Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
9.09Single6FFHFenobam6FFH-mGlu5-Fenobam
9.09Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
9.09Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
9.09Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
9.09Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
9.09Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
9.09Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
9.09Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
9.09Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
9.09Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
9.09Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
9.09Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
9.09Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/&β;1/&γ;2
9.09Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
9.09Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
9.09Consensusp2y12_offOrthosteric Ligand4NTJ-P2Y12-AZD1283 7PP1-P2Y12-Selatogrel
9.09Consensussmo_offOrthosteric Ligand5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
8.82Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
8.82Consensuscalcitonin_onOrthosteric Ligandct_on ctlike_on
8.82Consensuscrf1_onOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
8.82Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
8.82Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
8.82Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
8.70Single4JKVTaladegib (LY2940680)4JKV-SMO-Taladegib (LY2940680)
8.70Single4NTJAZD12834NTJ-P2Y12-AZD1283
8.70Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
8.70Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
8.70Single6Z4SSR486926Z4S-NTS1-SR48692
8.70Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
8.70Single8GDAL9026888GDA-EP4-L902688-Gs/&β;1/&γ;2
8.70Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
8.70Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
8.57Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
8.57Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
8.57Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
8.33Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
8.33Single5V57TC1145V57-SMO-TC114
8.33Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
8.33Single7F1TMIP-1a7F1T-CCR5-MIP-1a
8.33Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
8.33Single8GDBPGE28GDB-EP4-PGE2-Gs/&β;1/&γ;2
8.33Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.33Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
8.33Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
8.11Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
8.11Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
8.11Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
8.11Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
8.00Single4PY02MeSATP4PY0-P2Y12-2MeSATP
8.00Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
8.00Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
8.00Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
8.00Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.00Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.00Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/&β;1/&γ;2
8.00Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
8.00Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
8.00Consensusep_onOrthosteric Ligandep4_on ep2_on ep3_on
8.00Consensusnts1_onOrthosteric Ligand6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
8.00Consensusnts_onOrthosteric Ligandnts1_on
7.89Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
7.89Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
7.69Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/&β;1/&γ;2
7.69Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
7.69Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
7.69Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2
7.69Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
7.69Consensusadgrg2_onOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
7.69Consensuscyslt2_offOrthosteric Ligand6RZ6-CysLT2-ONO-2570366 6RZ9-CysLT2-ONO-2770372 6RZ8-CysLT2-ONO-2080365
7.69Consensuscyslt_offOrthosteric Ligandcyslt2_off
7.69Consensusep2_onOrthosteric Ligand7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
7.41Single6KNMJN241-96KNM-Apelin-JN241-9
7.41Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
7.41Single8SAI1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
7.32Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
7.14Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
7.14Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
7.14Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
7.14Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
6.67Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
6.25Single6W25Ca6W25-MC4-SHU9119-Ca
6.25Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
6.25Consensusccr8_offOrthosteric Ligand8TLM-CCR8-Anti-murine CCR8 antibody
6.06Consensusghrh_onOrthosteric Ligand7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
5.88Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
5.88Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
5.88Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
5.88Consensusclass-c_onOther Ligandgabab_on mglu_on
5.88Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
5.56Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
5.56Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/&β;1/&γ;2
5.26Single4XNWMRS25004XNW-P2Y1-MRS2500
5.26Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
5.26Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
5.26Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
5.13Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
5.00Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
5.00Single4O9RCyclopamine4O9R-SMO-Cyclopamine
5.00Single7XKFBetahydroxyandrosterone7XKF-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
5.00Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
5.00Single8J6QCompound 9n8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
5.00Consensusgo_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
5.00Consensusgo_proteinOrthosteric Ligandgo_chemokine
5.00Consensushca2_on_alloOther Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
5.00Consensusm4_on_alloOther Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
4.88Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
4.76Single4BWBNeurotensin4BWB-NTS1-Neurotensin
4.76Single4K5YCP-3763954K5Y-CRF1-CP-376395
4.76Single4QINSAG1.54QIN-SMO-SAG1.5
4.76Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
4.76Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
4.76Single6WWZCCL206WWZ-CCR6-CCL20-Go/&β;1/&γ;2
4.76Single8G94CD698G94-S1P1-CD69-Gi1/&β;1/&γ;2
4.76Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
4.76Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2
4.76Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
4.76Consensusclass-f_offOrthosteric Ligandsmo_off
4.55Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
4.55Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.55Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
4.55Single8JD6N-(3-chlorophenyl)pyridine-2-carboxamide8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
4.55Consensusgi_class-fOrthosteric Ligandgi_frizzled
4.55Consensusgi_frizzledOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
4.35Single4Z9GCP-3763954Z9G-CRF1-CP-376395
4.35Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/&β;1/&γ;2
4.35Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
4.35Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
4.35Single8GTIBMK-C2058GTI-CRF1-BMK-C205
4.17Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.17Single8GTGBMK-I1528GTG-CRF1-BMK-I152
4.00Single6OS1TRV0266OS1-AT1-TRV026
4.00Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
4.00Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
4.00Consensusmglu2_onOther Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
3.85Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1
3.85Single8GTMBMK-C2038GTM-CRF1-BMK-C203
3.70Single7CX2PGE27CX2-EP2-PGE2-Gs/&β;1/&γ;2
3.45Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
2.70Single7TYIAmylin7TYI-CT-Amylin-Gs/&β;1/&γ;2
2.50Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
2.22Consensusgs_ctOrthosteric Ligand7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.13Single8F0JPramlintide analogue san458F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2

Consensus Members
Id Members
bb2_off 7W41-BB2-PD176252
Net Summary
Imin 3.89
Number of Linked Nodes 249
Number of Links 261
Number of Hubs 29
Number of Links mediated by Hubs 130
Number of Communities 4
Number of Nodes involved in Communities 32
Number of Links involved in Communities 43
Path Summary
Number Of Nodes in MetaPath 57
Number Of Links MetaPath 56
Number of Shortest Paths 33342
Length Of Smallest Path 3
Average Path Length 12.2519
Length of Longest Path 27
Minimum Path Strength 1.405
Average Path Strength 7.171
Maximum Path Strength 21.17
Minimum Path Correlation 0.7
Average Path Correlation 0.921409
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 4.7619
Average % Of Corr. Nodes 53.9302
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 43.0212
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following differences:
Id1st Network2nd Network
bombesin_off_onbombesin_offbombesin_on
This network is also present in following consensuses:
IdComponents
peptide_offopioid_off
angiotensin_off
bombesin_off
cck_off
endothelin_off
ghrelin_off
npy_off
nts_off
orexin_off
vasopressin-ot_off
tachykinin_off
sst_off



You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download bombesin_off.zip



You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.



You can also  read or  download a guide explaining the meaning of all files and numerical data.