Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
1NT.T31 3.76083405
2NT.Y42 5.66833617
3NT.F65 5.82917407
4NT.V69 4.69733515
5NT.W71 6.27778619
6NT.Y73 1.71267504
7NT.C84 4.18583409
8NT.P85 6.85417418
9NT.W86 5.65167401
10NT.Y87 8.07167414
11NT.P89 4.37083413
12NT.W90 8.652514
13NT.L100 3.24404
14NT.R101 6.19583418
15NT.N120 7.232513
161x29 4.4425412
171x37 2.88413
181x39 2.7325416
191x43 5.432517
201x47 5.14857717
21I1x49 8.925447
222x46 6.90667409
232x57 6608
242x60 5.95944618
252x67 8.19416
263x37 5.18083416
273x44 6.19667418
283x46 9.43267509
293x48 5.47417408
303x50 8.56417409
313x53 5.70333408
323x57 6.64667408
334x46 4.03467508
344x50 7.55409
354x53 5.25409
364x60 6.97933518
374x64 9.356518
384x68 5.47083415
39E2x51 8.26611619
405x37 11.8175416
415x54 7.49867569
425x57 3.47469
435x61 3.40333469
445x64 7.406674119
456x52 7.55408
466x53 7.13417
476x56 5.51389617
48E3.E362 4.22583405
497x34 3.86111615
507x37 4.87417
517x41 8.2575417
527x51 5.655405
537x57 8.56417408
548x56 5.19467548
55Lig 11.81324210
56G.hns1.01 6.554174133
57G.S1.02 5.966674126
58G.S1.03 5.42833409
59G.S3.01 3.871674126
60G.S3.03 6.072226128
61G.S3.04 7.25167427
62G.S3.05 5.53083408
63G.S3.06 7.432526
64G.H2.06 6.40278629
65G.H2.07 5.83583409
66G.h2s4.01 8.77833409
67G.h2s4.03 4.62917427
68G.S4.04 3.18733509
69G.H3.01 1.1409
70G.H3.03 3.12333404
71G.H3.06 4.89083406
72G.H3.09 5.24533599
73G.H3.13 9.08333596
74G.H3.17 11.5483425
75G.S5.03 3.8454119
76G.S5.05 4.53933509
77G.S5.06 5.14583499
78G.s5hg.01 3.042786169
79G.hgh4.02 3.28333408
80G.hgh4.05 8.95533506
81G.hgh4.08 8.06333407
82G.hgh4.11 3.5625404
83G.hgh4.21 6.03417404
84G.H4.03 3.25083404
85G.H4.07 6.86833495
86G.H4.10 9.671335146
87G.H4.12 6.33583495
88G.H4.14 6.294174146
89G.H4.15 6.93833498
90G.h4s6.02 3.78083498
91G.S6.02 9.996675118
92G.S6.05 7.49595
93G.H5.08 5.459174129
94G.H5.20 4.4975468
95G.H5.26 4.15583467
96b.1x4 2.3125408
97b.h2x1 4.14417405
98b.h2x5 3.48083405
99b.lhb1x6 4.60167643
100b.lhb1x11 4.09583444
101b.b1x6 7.66539
102b.l1x3 9.188539
103b.l1x6 12.5892429
104b.b2x1 4.82167428
105b.b2x5 6.44111637
106b.b3x2 5.59417435
107b.b3x3 3.76733508
108b.l3x2 6.2485139
109b.b4x6 7.785839
110b.b4x7 6.315438
111b.l4x2 8.80417434
112b.b5x3 6.41167639
113b.b5x7 6.98583407
114b.l5x1 4.26583408
115b.l5x5 6.76191729
116b.b6x1 4.63529
117b.b7x1 5.90067504
118b.b8x4 5.495335186
119b.l9x3 5.51952779
120b.l9x6 5.54056628
121b.b10x2 3.995406
122b.b10x3 3.82417478
123b.b10x5 4.25933509
124b.l10x1 4.57417483
125b.b11x2 4.72533577
126b.b11x3 4.86667485
127b.b11x4 4.466579
128b.l11x2 7.04067579
129b.b12x6 8.40095778
130b.b13x7 6.868587
131b.l13x3 6.60611689
132b.l13x6 6.615429
133b.l13x7 4.99083489
134b.b15x1 6.26533589
135b.l15x1 5.87733527
136b.l15x2 5.92489
137b.b16x4 8.26167486
138b.b16x6 8.90905788
139b.b16x7 9.6025459
140b.b17x5 6.71583457
141b.b17x7 6.92458
142b.l17x3 9.37055659
143b.l17x6 8.55867529
144b.b18x3 4.96417458
145b.l18x1 6.375428106
146b.l18x2 5.885834107
147b.l18x3 7.685105
148b.b19x2 5.43056656
149b.l19x1 7.55429
150b.l19x2 8.35667459
151b.b20x4 8.66944658
152b.b20x6 6.12667756
153b.l20x2 5.49333409
154b.b21x1 6.226557
155b.b21x5 5.01404
156b.b21x7 6.31933505
157b.b22x5 5.221676107
158b.l22x5 7.67467549
159b.b23x6 6.848577197
160b.l23x1 8.66583426
161b.b24x3 3.95733545
162b.b24x5 4.09333405
163b.l25x3 8.93667549
164b.l25x6 12.9047528
165b.b26x3 3.262546
166b.l26x5 4.51583435
167b.b27x1 3.27583446
168b.b27x3 5.3825448
169b.l27x1 11.1583629
170b.l27x2 8.26917449
171b.b28x3 5.20167437
172b.b28x4 6.255446
173b.b28x6 6.67278649
174g.l1x4 7.55458
175g.h2x11 7.838334106
176g.ctx3 5.90556649
177g.ctx5 4.46583449
178g.ctx6 3.29546
179g.ctx9 2.96167406
180g.ctx14 4.72833439
181g.ctx15 6.5525439
182g.ctx16 4.745638
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
12x60 Lig 51.37439.45667YesYes180
22x57 3x43 28.341614.9033YesNo089
32x60 3x43 55.23529.64YesNo089
42x53 3x50 59.67614.86NoYes099
52x53 2x57 32.32877.71333NoYes098
62x53 3x47 27.25853.22667NoNo099
73x43 3x47 27.14434.12NoNo099
8I1x49 b.l25x4 13.944811.1167YesNo475
9b.l25x4 b.l27x2 22.52474.87667NoYes459
10b.l25x3 b.l27x2 24.66345.04YesYes499
11b.b27x3 b.l25x3 17.81029.12333YesYes489
12b.b26x3 b.b27x1 10.89492.98YesYes466
13b.b27x1 g.ctx5 16.1683.47667YesYes469
14g.ctx3 g.ctx5 40.32993.16667YesYes499
15g.ctx3 g.ctx4 98.04195.36667YesNo097
16g.ctx4 g.ctx9 98.69522.94333NoYes076
17g.ctx14 g.ctx9 1003.94333YesYes096
18b.l26x5 g.ctx14 50.87843.27YesYes359
19b.l26x5 g.ctx16 34.48172.90333YesYes358
20b.b28x5 g.ctx16 36.14013.76667NoYes058
21b.b1x6 b.b28x5 36.22642.85333YesNo095
22b.b1x6 b.b4x6 36.109120.5YesYes399
23b.b4x6 b.l1x3 36.37073.88YesYes399
24b.b3x6 b.l1x3 36.87179.76NoYes099
25b.b3x6 b.l3x2 36.94018.34NoYes099
26b.l1x4 b.l3x2 33.28315.88333NoYes1369
27G.HN.51 b.l1x4 78.44646.58NoNo056
28G.HN.51 I2.E253 78.32129.45NoNo055
292x45 I2.E253 78.00555.17333NoNo085
302x45 3x53 77.94195.41NoYes088
312x49 3x53 61.26112.82333NoYes098
322x49 3x50 61.17226.83NoYes099
33b.b28x6 b.lhb1x11 22.28883.10333YesYes494
34b.lhb1x11 g.ctx5 23.83384.71YesYes449
35b.b28x4 b.b28x6 11.88267.34667YesYes469
36g.ctx14 g.ctx15 51.07434.89YesYes399
37g.ctx15 g.ctx16 34.47833.85YesYes398
383x53 3x57 20.199310.94YesYes088
393x57 G.H5.19 14.24069.42667YesNo088
40G.S1.04 G.S3.03 10.86864.05667NoYes078
41G.S1.02 G.S3.03 12.38947.16667YesYes1268
42G.H5.15 G.S1.02 13.796.63NoYes086
43G.H5.15 G.H5.19 13.94043.09333NoNo088
44g.ctx3 g.ctx6 46.75424.07YesYes496
45G.S1.03 G.hns1.01 50.916713.0333YesYes093
46G.hns1.01 b.l1x4 45.22565.47YesNo1336
47G.S1.03 G.S3.06 20.14032.85333YesYes096
48G.S1.03 G.h2s4.03 21.74542.77667YesYes097
49G.H2.07 G.h2s4.01 38.74374.01YesYes099
50b.l7x2 b.l9x6 33.41262.73333NoYes298
51b.l5x5 b.l7x2 38.75325.31333YesNo299
52G.S3.06 b.l5x5 19.55215.7YesYes269
53G.h2s4.03 b.l5x5 35.68372.97667YesYes279
54G.H2.06 b.l9x6 32.85443.58YesYes298
55G.H2.06 b.l17x6 15.90828.3YesYes299
56G.H2.04 G.H2.07 39.60657.66667NoYes099
57G.H2.04 G.H3.08 39.12314.85667NoNo099
58G.H2.06 b.l19x1 15.67635.53YesYes299
59b.l1x6 b.l27x1 17.784525.9167YesYes299
60b.b2x1 b.l27x1 41.66015.14333YesYes289
61b.l3x1 b.l5x5 16.76838.03333NoYes099
62G.H3.08 G.S4.04 38.64565.68333NoYes099
63G.S4.04 G.S5.04 35.25753.25YesNo099
64G.S5.04 G.S5.06 14.20796.45667NoYes999
65G.H3.06 G.H4.15 12.78497.31YesYes068
66G.H4.15 G.S5.04 20.56499.34YesNo989
67G.S5.06 G.S6.05 11.81734.87YesYes995
68b.l11x1 b.l9x6 32.55525.79NoYes098
69b.b11x6 b.l11x1 32.34463.71NoNo099
70b.b11x6 b.l9x3 30.804112.55NoYes799
71b.b11x4 b.l9x3 23.5524.11YesYes799
72b.b10x3 b.b11x4 18.48593.38YesYes789
73b.b10x3 b.b6x2 18.21446.76YesNo088
74b.b10x2 b.b6x2 17.99542.25333YesNo068
75b.b10x2 b.b11x5 11.262.86667YesNo066
76b.b11x5 b.l13x7 11.03874.85NoYes069
77b.l17x5 b.l17x6 15.53354.41667NoYes269
78b.b19x6 b.l17x5 30.57232.71667NoNo096
79b.b19x6 b.l17x3 27.03329.76NoYes099
80b.b20x6 b.l17x3 20.8424.53YesYes569
81b.b17x7 b.b20x6 11.548810.3633YesYes586
82b.l17x5 b.l19x1 15.47665.89NoYes269
83b.l22x5 g.ctx6 39.07034.85667YesYes496
84b.l22x5 b.lhb1x3 19.20813.34333YesNo092
85b.h2x5 b.lhb1x3 18.50713.04YesNo052
86b.h2x1 b.h2x5 34.89043.44YesYes055
87b.b21x5 b.h2x1 28.51756.59333YesYes045
88b.l22x5 b.l24x2 18.85228.90667YesNo096
89b.h2x5 b.l24x2 18.50173.93YesNo056
90b.b26x1 b.l27x1 67.30416.18NoYes099
91b.b26x1 b.b26x2 67.23273.44NoNo097
92b.b26x2 b.b2x3 67.19364.86NoNo076
93b.b2x5 b.l4x1 50.13934.94YesNo375
94b.b2x5 b.l26x1 16.829110.1067YesNo377
95b.b6x1 b.l7x1 10.50883.49YesNo099
96b.b7x5 b.l7x1 10.27852.11NoNo099
97b.b7x4 b.b7x5 10.04811.96NoNo089
98b.l4x1 b.l4x2 16.96343.39333NoYes354
99b.l26x1 b.l26x3 16.6225.78NoNo377
100b.l22x2 g.ctx3 10.72493.69NoYes019
101b.l22x2 g.ctx2 10.37123.15NoNo013
102g.ctx2 g.h2x15 10.019614.36NoNo036
103b.b21x5 b.b21x7 24.26919.18YesYes045
104b.b20x3 b.b21x7 11.43464.03NoYes085
105b.b21x7 b.b24x6 11.43469.00667YesNo058
106b.l4x2 g.ctx15 16.749710.2YesYes349
107b.l26x3 b.l26x5 16.55554.62NoYes375
108b.b2x3 b.b2x5 66.41486.97667NoYes367
109b.l4x1 g.ctx16 33.1294.84NoYes358
110G.h2s4.01 b.l5x5 32.17419.68667YesYes099
111b.b2x1 b.b6x1 33.06597.18YesYes289
112b.b6x1 b.l9x6 30.09954.79YesYes298
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
E2.R289NT.T314.743331NoYes0012
LigNT.A323.113331YesNo0001
NT.L35NT.P892.733331NoYes0012
LigNT.L3510.05331YesNo0001
LigNT.Y3610.40671YesNo0001
NT.F65NT.W395.013330YesNo0021
NT.W39NT.Y8710.28671NoYes0011
LigNT.W3920.06671YesNo0001
NT.F65NT.Y423.093330YesYes0022
NT.V69NT.Y423.366671YesYes0022
NT.P85NT.Y426.953331YesYes0022
NT.Y42NT.Y8710.261YesYes0021
NT.D66NT.W717.821NoYes0022
NT.D66NT.R1013.571NoYes0021
NT.D66NT.R1137.151NoNo0021
LigNT.M679.051YesNo0001
NT.V69NT.Y682.943331YesNo0021
NT.H115NT.Y683.266671NoNo0011
LigNT.Y687.131YesNo0001
NT.V69NT.W716.131YesYes0022
NT.P85NT.V697.656671YesYes0022
NT.R101NT.W7111.331YesYes0012
NT.P85NT.Y877.876671YesYes0021
NT.L88NT.P854.931NoYes0022
LigNT.Y873.863331YesYes0001
NT.L88NT.P892.733331NoYes0022
NT.L88NT.W904.933331NoYes0021
NT.P89NT.W909.911YesYes0021
NT.V94NT.W905.313330NoYes0021
NT.N120NT.W9017.70331YesYes0011
LigNT.W905.41YesYes0001
NT.R101NT.W1096.996671YesNo0012
LigNT.R1139.863331YesNo0001
LigNT.H11511.25331YesNo0001
NT.N120NT.P1216.521YesNo0012
NT.E122NT.N1206.133330NoYes0021
LigNT.N1203.081YesYes0001
1x29NT.E1222.723331YesNo3012
1x261x294.831NoYes3311
1x26Lig6.266671NoYes3010
1x291x325.073331YesNo3512
1x29Lig5.143331YesYes3010
1x30Lig3.576670NoYes3010
1x327x358.980NoNo5522
1x33Lig12.86331NoYes3010
1x36Lig11.51330NoYes5010
1x37Lig7.411YesYes3010
1x397x393.421YesNo7612
1x39Lig3.251YesYes7010
1x401x435.636671NoYes7711
1x402x685.656671NoNo7012
1x40Lig15.131NoYes7010
1x431x475.296671YesYes7611
1x432x683.066671YesNo7012
1x437x423.631YesNo7911
1x43Lig9.531YesYes7010
1x472x602.743331YesYes6611
1x472x648.461YesNo6711
1x477x468.91YesNo6912
1x47Lig5.631YesYes6010
2x603x406.973331YesNo6811
2x603x439.641YesNo6912
2x603x443.431YesYes6812
2x60Lig9.456671YesYes6010
2x64Lig3.606671NoYes7010
2x673x338.181YesNo0612
2x673x369.056671YesNo0612
2x67Lig14.141YesYes0010
2x71E2x527.953330NoNo0621
E1.P197Lig5.623330NoYes0010
E1.G198E1.P1993.383330NoNo0021
E1.P199Lig3.311NoYes0010
3x333x374.693330NoYes6521
3x374x606.571YesYes5812
3x375x394.573331YesNo5312
3x40Lig14.28671NoYes8010
3x446x535.236671YesYes8522
4x605x3913.70331YesNo8322
E2x50E2x524.560NoNo9621
E2x52Lig14.22331NoYes6010
E2.R289Lig14.71NoYes0010
5x37E2.N29024.10671YesNo0011
E2.N290Lig7.451NoYes0010
5x375x393.523331YesNo0312
5x375x40121YesNo0312
5x37Lig7.641YesYes0010
5x40E3.E3625.040NoYes3022
6x537x417.191YesYes5521
6x567x377.031YesYes0722
6x567x4115.54671YesYes0521
7x34E3.A3652.763331YesNo6012
7x347x353.206671YesNo6512
7x347x382.833331YesNo6811
7x34Lig9.61YesYes6010
7x377x415.41YesYes7521
7x38Lig5.666671NoYes8010
7x41Lig4.893331YesYes5010
7x42Lig8.693331NoYes9010
1x26NT.N1202.723331NoYes3011
2x607x453.513331YesNo6911
E1.R196Lig4.206670NoYes0010
E1.Y200Lig5.143331NoYes0010
3x37Lig4.886671YesYes5010
7x45Lig4.793331NoYes9010
LigNT.R1012.886671YesYes0001
1x331x372.713331NoYes3311
7x34E3.E3624.263331YesYes6012
1x472x612.666671YesNo6712
1x351x392.376670NoYes6721
1x472x652.343331YesNo6012
1x391x421.883331YesNo7812
2x673x321.383331YesNo0612
E1.L201E1.Y2001.173330NoNo0021
E1.G202NT.Y360.9666670NoNo0021
1x371x410.9533331YesNo3512
7x317x340.50NoYes4621
1x341x370.4433330NoYes4321

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Consensusgip_onOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
81.48Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
81.48Consensusvpac2_on_gpOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
74.07Consensussecretin_onOrthosteric Ligand7D3S-Secretin-Secretin-Gs/β1/γ2
71.43Consensussecretin_on_gpOrthosteric Ligand7D3S-Secretin-Secretin-Gs/β1/γ2
70.37Consensusvpac1_onOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
67.86Consensusvpac1_on_gpOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
65.52Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
65.52Consensusglp2_on_gpOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
59.38Consensusglp1_onOrthosteric Ligand7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
58.82Consensusgluc_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
57.58Consensusglp1_on_gpOrthosteric Ligand7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
57.14Consensusgluc_on_gpOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
56.67Consensuspac1_onOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
56.67Consensuspac1_on_gpOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
52.94Consensuspth1_on_gpOrthosteric Ligand6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
51.43Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
51.35Consensuspth2_on_gpOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
48.48Consensusctlike_on_gpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
46.88Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
44.12Consensuspth1_onOrthosteric Ligand6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
42.86Single7RBTTirzepatide7RBT-GIP-Tirzepatide-LSN3556672-chim(NtGi1-Gs)/β1/γ2
42.86Consensuscrf1_onOrthosteric Ligand6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF1-Corticoliberin-Gs/β1/γ2
41.67Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
41.18Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
40.54Consensuscrf1_on_gpOrthosteric Ligand6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF1-Corticoliberin-Gs/β1/γ2
38.24Consensuscrf2_on_gpOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
37.14Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
36.84Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
36.36Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
36.36Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ2
36.36Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
35.00Consensusglucagon_on_gpOrthosteric Ligandglp_on_gp gluc_on_gp secretin_on_gp gip_on_gp
34.29Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
34.29Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
34.29Single9BLWCagrilintide backbone (non-acylated)9BLW-CT (AMY1)-Cagrilintide backbone (non-acylated)-Gs/β1/γ2; RAMP1
34.29Consensusvpac_on_gpOrthosteric Ligandvpac1_on_gp vpac2_on_gp
33.33Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
33.33Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
33.33Consensusglp_onOrthosteric Ligandglp1_on glp2_on
33.33Consensusglp_on_gpOrthosteric Ligandglp1_on_gp glp2_on_gp
32.56Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
32.50Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
32.50Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
32.50Consensusglucagon_onOrthosteric Ligandglp_on gluc_on secretin_on gip_on
32.43Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
32.43Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
32.43Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
32.43Single9BTWCagrilintide9BTW-CT (AMY3)-Cagrilintide-Gs/β1/γ2; RAMP3
32.43Single9BYOExendin-39BYO-GLP-1-Exendin-3-Gs/β1/γ2
32.43Consensusvip-pacap_onOrthosteric Ligandvpac_on pac_on
32.43Consensusvip-pacap_on_gpOrthosteric Ligandvpac_on_gp pac_on_gp
32.35Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
32.35Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
31.82Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
31.43Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
31.43Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
31.43Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
31.43Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
31.43Consensusvpac_onOrthosteric Ligandvpac1_on vpac2_on
30.77Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
30.56Single6FJ3PTH6FJ3-PTH1-PTH
30.56Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
30.56Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
30.56Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
30.56Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
30.56Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
30.56Single9BLBCagrilintide backbone (non-acylated)9BLB-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
30.56Single9BP3Cagrilintide9BP3-CT (AMY1)-Cagrilintide-Gs/β1/γ2; RAMP1
30.00Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
29.73Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
29.73Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
29.73Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
29.73Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
29.73Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
29.73Single9BUCCagrilintide9BUC-CT-Cagrilintide-Gs/β1/γ2
29.41Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
29.27Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
29.03Single9C0KExendin-49C0K-GLP-1-Exendin-4-Gs/β1/γ2
28.95Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
28.95Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
28.57Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
28.57Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
28.57Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
28.57Single9BLCCagrilintide backbone (non-acylated)9BLC-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
28.57Single9EBOGLP-1 (ACPC18)9EBO-GLP-1-GLP-1 (ACPC18)-Gs/β1/γ2
28.21Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
28.12Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
27.78Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
27.78Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
27.78Consensuscalcitonin_onOrthosteric Ligandctlike_on
27.78Consensuspac_onOrthosteric Ligandpac1_on
27.66Consensusclass-b1_on_gpOrthosteric Ligandglucagon_on_gp vip-pacap_on_gp pth_on_gp crf_on_gp calcitonin_on_gp
27.50Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
27.50Single9AUCCalcitonin gene-related peptide-19AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
27.27Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
27.27Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
27.27Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
27.03Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
27.03Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
27.03Single9BUBCagrilintide9BUB-CT-Cagrilintide-Gs/β1/γ2
27.03Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
27.03Consensuscalcitonin_on_gpOrthosteric Ligandctlike_on_gp
27.03Consensuspac_on_gpOrthosteric Ligandpac1_on_gp
26.83Consensuscrf_on_gpOrthosteric Ligandcrf2_on_gp crf1_on_gp
26.47Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
26.47Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
26.47Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
26.32Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
26.32Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
26.32Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
26.32Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
26.19Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
25.93Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
25.81Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
25.81Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
25.64Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
25.64Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
25.64Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
25.64Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
25.64Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
25.64Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
25.64Single9BQ3Cagrilintide9BQ3-CT (AMY2)-Cagrilintide-Gs/β1/γ2; RAMP2
25.58Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
25.00Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
25.00Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
25.00Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
25.00Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
25.00Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
25.00Single9BUDCagrilintide9BUD-CT-Cagrilintide-Gs/β1/γ2
25.00Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
25.00Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
25.00Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
25.00Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
25.00Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
24.44Consensusclass-b1_onOrthosteric Ligandglucagon_on vip-pacap_on pth_on crf_on calcitonin_on
24.39Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
24.39Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
24.32Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
24.32Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
24.32Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
24.24Single7SK9CCX6627SK9-ACKR3-CCX662
24.24Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
24.24Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
24.14Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
24.14Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
24.14Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
24.14Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
24.14Single9IVGGLP-1 (Truncated)9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
24.14Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
24.14Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
24.14Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
24.14Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
24.14Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
24.14Consensushca_on_gpOrthosteric Ligandhca2_on_gp
23.81Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
23.68Single4XT3Fractalkine4XT3-US28-Fractalkine
23.68Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
23.68Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
23.53Single4XT1Fractalkine4XT1-US28-Fractalkine
23.53Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
23.53Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
23.53Single8U4OCXCL128U4O-CXCR4-CXCL12-Gi1/β1/γ2
23.53Single8YWFRetatrutide8YWF-GLP-1-Retatrutide-chim(NtGi1-Gs)/β1/γ2
23.53Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
23.53Consensuslpl_onOrthosteric Ligands1p_on lpa_on
23.53Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
23.53Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
23.40Consensuspth_on_gpOrthosteric Ligandpth1_on_gp pth2_on_gp
23.33Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
23.33Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
23.33Single9CIBFCH-22964139CIB-HCA2-FCH-2296413
23.26Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
23.26Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
23.26Consensusclass-a_class-b1_cons_on_gpOrthosteric Ligandclass-a_on_gp class-b1_on_gp
23.08Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
23.08Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
23.08Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
22.86Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
22.86Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
22.86Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
22.86Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
22.86Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
22.86Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
22.86Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
22.86Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
22.58Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
22.58Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
22.58Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
22.58Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
22.50Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
22.50Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
22.50Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
22.22Single5WF5UK-4320975WF5-A2A-UK-432097
22.22Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
22.22Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
22.22Single8K5BNiacin8K5B-HCA2-Niacin
22.22Consensusangiotensin_onOrthosteric Ligandat1_on
22.22Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
22.22Consensusclass-b1_class-b2_cons_onOrthosteric Ligandclass-b1_on class-b2_on
22.22Consensusclass-b1_class-b2_cons_on_gpOrthosteric Ligandclass-b1_on_gp class-b2_on_gp
22.22Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
21.95Consensusclass-a_class-b1_cons_onOrthosteric Ligandclass-a_on class-b1_on
21.88Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
21.88Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
21.88Single6OS2TRV0266OS2-AT1-TRV026
21.88Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
21.88Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
21.88Single9EBIPiclidenoson9EBI-A3A-Piclidenoson-chim(NtGi1L-Gs-CtGi1)/β1/γ2
21.88Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
21.62Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
21.62Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
21.62Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
21.62Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
21.62Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
21.62Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
21.43Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
21.43Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
21.43Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
21.43Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
21.43Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
21.43Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
21.43Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
21.43Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
21.21Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
21.21Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
21.21Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
21.21Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
21.05Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
21.05Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
21.05Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
21.05Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
21.05Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
21.05Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
21.05Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
21.05Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
21.05Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
21.05Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
21.05Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
21.05Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
21.05Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
20.69Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
20.69Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
20.69Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
20.69Single8K5CAcipimox8K5C-HCA2-Acipimox
20.69Single9JFUNE52-QQ579JFU-GPR4-NE52-QQ57
20.69Single9K0KUTP9K0K-P2Y4-UTP-chim(NtGi1-Gs-CtGq)/β1/γ2
20.69Consensushca_onOrthosteric Ligandhca2_on
20.59Single4UG2CGS216804UG2-A2A-CGS21680
20.59Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
20.59Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
20.59Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
20.59Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
20.59Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
20.59Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
20.59Single9IZASCH9002719IZA-HCA2-SCH900271-Gi1/β1/γ2
20.59Single9M0RNeuropeptide VF9M0R-NPFF1-Neuropeptide VF-Gi1/β1/γ2
20.59Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
20.59Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
20.59Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
20.51Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
20.51Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
20.51Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
20.51Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
20.45Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
20.00Single4YAYZD-71554YAY-AT1-ZD-7155
20.00Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
20.00Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
20.00Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/β1/γ2
20.00Single7F8XNN90567F8X-CCKA-NN9056
20.00Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
20.00Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
20.00Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
20.00Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
20.00Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
20.00Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
20.00Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
20.00Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
20.00Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
20.00Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
20.00Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
20.00Single8K5DGSK2560738K5D-HCA2-GSK256073
20.00Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
20.00Single9BUECagrilintide9BUE-CT-Cagrilintide-Gs/β1/γ2
20.00Single9IZCMK19039IZC-HCA2-MK1903-Gi1/β1/γ2
20.00Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
20.00Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
20.00Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
20.00Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
20.00Consensuspth_onOrthosteric Ligandpth1_on pth2_on
20.00Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
20.00Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
19.57Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
19.57Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
19.51Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
19.51Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
19.51Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
19.51Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
19.51Consensusbradykinin_onOrthosteric Ligandbk2_on
19.51Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
19.51Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
19.44Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
19.44Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
19.44Single9E82SDF-1-beta9E82-ACKR3-SDF-1-β-Arrestin2
19.44Single9IQVMuscarinic toxin 39IQV-Alpha1A-Muscarinic toxin 3
19.44Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
19.44Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
19.44Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
19.44Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
19.44Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
19.35Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
19.35Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
19.35Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
19.35Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
19.35Single7LD3Adenosine7LD3-A1-Adenosine-MIPS521-Gi2/β1/γ2
19.35Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
19.35Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
19.35Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
19.35Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
19.35Single8XYKVUF106618XYK-CXCR3-VUF10661-Go/β1/γ2
19.35Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
19.35Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
19.35Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
19.35Consensusa3_on_gpOrthosteric Liganda3a_on_gp
19.35Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
19.35Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
19.35Consensusadgrg2_onOrthosteric Ligand7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
19.35Consensusadgrg2_on_gpOrthosteric Ligand7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
19.35Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
19.35Consensusep_offOrthosteric Ligandep4_off
19.35Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
19.35Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
19.05Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
19.05Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
19.05Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
18.92Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
18.92Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
18.92Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
18.92Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
18.92Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
18.92Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
18.92Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
18.92Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
18.92Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
18.92Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
18.92Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
18.92Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
18.75Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
18.75Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
18.75Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
18.75Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
18.75Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
18.75Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
18.75Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
18.75Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
18.75Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
18.75Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
18.75Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
18.75Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
18.75Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
18.75Single9JMCDS-3801b9JMC-Motilin-DS-3801b-chim(Gs-CtGq)/β1/γ2
18.75Consensusa2_onOrthosteric Liganda2b_on
18.75Consensusa2_on_gpOrthosteric Liganda2b_on_gp
18.75Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
18.75Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
18.75Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
18.75Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
18.75Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
18.75Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
18.75Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
18.75Consensusrelaxin_onOrthosteric Ligandrxfp4_on
18.75Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
18.75Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
18.75Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
18.52Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
18.42Single6JODAngiotensin II6JOD-AT2-Angiotensin II
18.42Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
18.42Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
18.42Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
18.42Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
18.42Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
18.42Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
18.42Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
18.42Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
18.42Single8ZBISomatostatin-148ZBI-SST3-Somatostatin-14-Gi1/β1/γ2
18.42Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
18.42Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
18.42Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
18.42Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
18.42Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
18.42Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
18.42Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
18.18Single4XEENeurotensin4XEE-NTS1-Neurotensin
18.18Single4XESNeurotensin4XES-NTS1-Neurotensin
18.18Single6YVRNTS8-136YVR-NTS1-NTS8-13
18.18Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
18.18Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
18.18Single7K15MKD0467K15-BLT1-MKD046-Na
18.18Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
18.18Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
18.18Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
18.18Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
18.18Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
18.18Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
18.18Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
18.18Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
18.18Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
18.18Single8XYIVUF106618XYI-CXCR3-VUF10661
18.18Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
18.18Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
18.18Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
18.18Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
18.18Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
18.18Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
18.18Consensuslpl_offOrthosteric Ligands1p_off lpa_off
18.18Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
18.18Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
17.95Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
17.95Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
17.95Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
17.95Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
17.95Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
17.95Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
17.95Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
17.95Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
17.95Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
17.95Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
17.95Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
17.95Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
17.95Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
17.95Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
17.86Single8HSCFab0468HSC-GPR20-Fab046-Gi1/β1/γ2
17.86Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
17.86Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
17.86Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
17.86Single9LMPNE52-QQ579LMP-GPR4-NE52-QQ57
17.65Single4BUONeurotensin4BUO-NTS1-Neurotensin
17.65Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
17.65Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
17.65Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
17.65Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
17.65Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
17.65Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
17.65Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
17.65Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-SBI-553-chim(NtGi1-Go)/β1/γ2
17.65Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
17.65Single8ZWGJR14a8ZWG-C3aB-JR14a-Gi1/β1/γ2
17.65Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
17.65Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
17.65Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.65Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.65Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
17.65Consensusprostanoid_offOrthosteric Ligandep_off dp_off
17.50Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
17.50Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
17.50Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
17.50Single9KFKRelaxin-39KFK-RXFP4-Relaxin-3-Gi2/β1/γ2
17.50Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
17.50Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
17.50Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
17.50Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
17.50Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
17.31Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
17.24Single3PWHZM-2413853PWH-A2A-ZM-241385
17.24Single4BWBNeurotensin4BWB-NTS1-Neurotensin
17.24Single5U09Taranabant5U09-CB1-Taranabant
17.24Single5ZKQABT-4915ZKQ-PAF-ABT-491
17.24Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
17.24Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
17.24Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
17.24Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
17.24Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
17.24Single9EBHAdenosine9EBH-A3A-Adenosine-Gi1/β1/γ2
17.24Consensusangiotensin_offOrthosteric Ligandat1_off
17.24Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
17.14Single5WF6UK-4320975WF6-A2A-UK-432097
17.14Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
17.14Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
17.14Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
17.14Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
17.14Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
17.14Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
17.14Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
17.14Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
17.07Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
17.07Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
17.07Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
17.07Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
17.07Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
17.07Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
17.07Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
17.07Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
17.07Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
17.07Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
16.67Single2YDOAdenosine2YDO-A2A-Adenosine
16.67Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
16.67Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
16.67Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
16.67Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
16.67Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
16.67Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
16.67Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
16.67Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
16.67Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
16.67Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
16.67Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
16.67Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
16.67Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
16.67Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
16.67Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
16.67Single8K2WAMG4878K2W-CXCR3-AMG487
16.67Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
16.67Single8WDTphotoNECA8WDT-A2A-photoNECA
16.67Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
16.67Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
16.67Single8ZPMAMD0708ZPM-CXCR4-AMD070
16.67Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
16.67Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single9JH3CMF-0199JH3-Apelin-CMF-019-Gi1/β1/γ2
16.67Single9K0XATP9K0X-P2Y2-ATP-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single9K20ATP9K20-P2Y2-ATP-chim(NtGi1-Go)/β1/γ2
16.67Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
16.67Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
16.67Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
16.67Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
16.67Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
16.67Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
16.67Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
16.67Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
16.67Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
16.67Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
16.67Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
16.67Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
16.67Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
16.67Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
16.28Single5GLHEndothelin-15GLH-ETB-Endothelin-1
16.28Single6IGKEndothelin-36IGK-ETB-Endothelin-3
16.28Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
16.28Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
16.28Consensusbombesin_onOrthosteric Ligandbb2_on
16.28Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
16.28Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
16.22Single3QAKUK-4320973QAK-A2A-UK-432097
16.22Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
16.22Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
16.22Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
16.22Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
16.22Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
16.22Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
16.22Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
16.22Single9IQSMuscarinic toxin 39IQS-M4-Muscarinic toxin 3
16.22Single9KFIRelaxin-39KFI-RXFP3-Relaxin-3-Gi2/β1/γ2
16.22Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
16.22Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
16.22Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
16.22Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
16.22Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
16.22Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
16.22Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
16.13Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
16.13Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
16.13Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
16.13Single5TGZAM65385TGZ-CB1-AM6538
16.13Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
16.13Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
16.13Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
16.13Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
16.13Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
16.13Single7V3ZCP559407V3Z-CB1-CP55940
16.13Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
16.13Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
16.13Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
16.13Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
16.13Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
16.13Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
16.13Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
16.13Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
16.13Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
16.13Single9H37A1IR09H37-A2A-A1IR0-Na
16.13Single9KFJPubChem 1383196749KFJ-RXFP3-PubChem 138319674-Gi2/β1/γ2
16.13Consensusa3_onOrthosteric Liganda3a_on
16.13Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
16.13Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
16.13Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
16.13Consensusblt_onOrthosteric Ligandblt1_on
16.13Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
16.13Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
16.13Consensusleukotriene_onOrthosteric Ligandblt_on
16.13Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
16.13Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
16.13Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
16.13Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
15.91Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
15.91Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
15.79Single3OE0CVX153OE0-CXCR4-CVX15
15.79Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
15.79Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
15.79Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
15.79Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
15.79Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
15.79Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
15.79Single9B5YLong-Acting PTH9B5Y-PTH1-Long-Acting PTH-chim(NtGi1-Gq)/β1/γ2
15.79Single9U4WGonadoliberin-19U4W-GnRH1-Gonadoliberin-1-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.79Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
15.79Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
15.79Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
15.79Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
15.79Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
15.79Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
15.79Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
15.79Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
15.79Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
15.62Single5C1MBU725C1M-μ-BU72
15.62Single5N2RPSB-365N2R-A2A-PSB-36-Na
15.62Single5T1ABMS-6815T1A-CCR2-BMS-681-PubChem 12093170
15.62Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
15.62Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
15.62Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
15.62Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.62Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
15.62Single8S4DCMF-0198S4D-Apelin-CMF-019
15.62Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
15.62Single8WGBVU01550418WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
15.62Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
15.62Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
15.62Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
15.62Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
15.62Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
15.62Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
15.62Single8ZYTNeurotensin peptide 8-138ZYT-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
15.62Single9B9ZA1AKO9B9Z-CB1-A1AKO
15.62Single9EE8Adenosine9EE8-A2A-Adenosine-Gs/β1/γ2
15.62Single9EHSLUF76029EHS-A3A-LUF7602
15.62Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
15.62Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
15.62Consensusblt_offOrthosteric Ligandblt1_off
15.62Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
15.62Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
15.62Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
15.62Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
15.62Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
15.62Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
15.62Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
15.62Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
15.62Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
15.56Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
15.38Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
15.38Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
15.38Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
15.38Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
15.38Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
15.38Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
15.22Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
15.15Single2YDVNECA2YDV-A2A-NECA
15.15Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
15.15Single4BV0Neurotensin4BV0-NTS1-Neurotensin
15.15Single4UHRCGS216804UHR-A2A-CGS21680
15.15Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
15.15Single5G53NECA5G53-A2A-NECA-Gs
15.15Single5XRAAM115425XRA-CB1-AM11542
15.15Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
15.15Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
15.15Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
15.15Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
15.15Single6OS1TRV0266OS1-AT1-TRV026
15.15Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
15.15Single7FEECP559407FEE-CB1-CP55940-ZCZ011
15.15Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
15.15Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
15.15Single7P2L4YI7P2L-mGlu5-4YI
15.15Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
15.15Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
15.15Single7TUYGSK682753A7TUY-GPR183-GSK682753A
15.15Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
15.15Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.15Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.15Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
15.15Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
15.15Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
15.15Single8E0GBU728E0G-μ-BU72
15.15Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
15.15Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
15.15Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
15.15Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
15.15Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
15.15Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
15.15Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
15.15Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
15.15Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
15.15Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
15.15Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
15.15Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
15.15Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
15.15Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
15.15Consensuslpa_onOrthosteric Ligandlpa1_on
15.15Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
15.15Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
15.15Consensusneurotensin_onOrthosteric Ligandnts1_on
15.15Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
15.15Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.15Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
15.00Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
15.00Single9JFYhNPSF9JFY-NPFF2-hNPSF-Gi1/β1/γ2
15.00Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
15.00Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
15.00Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
14.81Single8A2OTheophylline8A2O-A2A-Theophylline-Na
14.81Single9EE9Adenosine9EE9-A2A-Adenosine-Gs/β1/γ2
14.81Single9IVMLSN33188399IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
14.71Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
14.71Single4N4WSANT-14N4W-SMO-SANT-1
14.71Single5X33BIIL2605X33-BLT1-BIIL260
14.71Single6A93Risperidone6A93-5-HT2A-Risperidone
14.71Single6IIURamatroban6IIU-TXA2-Ramatroban
14.71Single6KQICP559406KQI-CB1-CP55940-Org27569
14.71Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
14.71Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
14.71Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
14.71Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
14.71Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
14.71Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
14.71Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
14.71Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
14.71Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.71Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
14.71Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
14.71Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
14.71Single8XJNCloprosetnol8XJN-TXA2-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
14.71Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
14.71Single9BJKNAM9BJK-μ-Naloxone-NAM
14.71Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
14.71Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
14.71Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
14.71Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
14.71Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
14.71Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
14.71Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
14.71Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
14.71Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
14.71Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
14.71Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
14.71Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
14.71Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
14.71Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
14.71Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
14.71Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
14.71Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
14.71Consensuslpa_offOrthosteric Ligandlpa1_off
14.71Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
14.71Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
14.71Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
14.63Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
14.63Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
14.63Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
14.63Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
14.63Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
14.29Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
14.29Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
14.29Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
14.29Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
14.29Single7EZCUKA7EZC-A2A-UKA
14.29Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
14.29Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
14.29Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
14.29Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
14.29Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
14.29Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
14.29Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
14.29Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
14.29Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
14.29Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
14.29Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
14.29Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
14.29Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
14.29Single8JPFNeurotensin8JPF-NTS1-Neurotensin-SBI-553
14.29Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
14.29Single8W8XBeta-MSH8W8X-MC3-β-MSH-Ca-Gs/β1/γ2
14.29Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
14.29Single8XJOU466198XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
14.29Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
14.29Single9DYEBuspirone9DYE-5-HT1A-Buspirone-Go/β1/γ2
14.29Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
14.29Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
14.29Single9M1HProstaglandin E29M1H-EP1-Prostaglandin E2-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single9M54Neuropeptide VF9M54-NPFF2-Neuropeptide VF-Gi1/β1/γ2
14.29Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
14.29Consensuscck_onOrthosteric Ligandccka_on cckb_on
14.29Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
14.29Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
14.29Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
14.29Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
14.29Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
14.29Consensustp_onOrthosteric Ligand8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Consensustp_on_gpOrthosteric Ligand8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
13.95Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
13.95Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
13.95Consensusendothelin_onOrthosteric Ligandetb_on eta_on
13.89Single3NY9ICI118-5513NY9-β2-ICI118-551
13.89Single5ZTYAM102575ZTY-CB2-AM10257
13.89Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
13.89Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
13.89Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
13.89Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
13.89Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
13.89Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
13.89Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
13.89Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
13.89Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
13.89Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
13.89Single8QJ2pN1628QJ2-MC4-pN162-Gs
13.89Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
13.89Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
13.89Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
13.89Single9IPVJR14a9IPV-C3aB-JR14a-Gi1/β1/γ2
13.89Single9IPYJR14a9IPY-C3aB-JR14a
13.89Single9MD1Buspirone9MD1-5-HT1A-Buspirone-Gz/β1/γ2
13.89Single9V2NMacimorelin9V2N-Ghrelin-Macimorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
13.89Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
13.89Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
13.89Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
13.89Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
13.89Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
13.79Single3OE9IT1t3OE9-CXCR4-IT1t
13.79Single6LI0C176LI0-GPR52-C17
13.79Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
13.79Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
13.79Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
13.79Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
13.79Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab
13.79Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
13.79Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
13.79Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
13.64Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
13.51Single4IARErgotamine4IAR-5-HT1B-Ergotamine
13.51Single7QA8Peptide7QA8-STE2-Peptide
13.51Single7QA8Peptide7QA8-STE2-Peptide
13.51Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
13.51Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
13.51Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
13.51Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
13.51Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
13.51Single8KIGSHU91198KIG-MC3-SHU9119-Ca
13.51Single8XWNCXCL88XWN-CXCR2-CXCL8
13.51Single9BUYLM1899BUY-β2-LM189-Gi1/β1/γ2
13.51Single9HB3Mambaquaretin-19HB3-V2-Mambaquaretin-1
13.51Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
13.51Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
13.51Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
13.51Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
13.51Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
13.51Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
13.51Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
13.51Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
13.33Single3ODUIT1t3ODU-CXCR4-IT1t
13.33Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
13.33Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
13.33Single4S0VSuvorexant4S0V-OX2-Suvorexant
13.33Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
13.33Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
13.33Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
13.33Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
13.33Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
13.33Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
13.33Single6TPJSuvorexant6TPJ-OX2-Suvorexant
13.33Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
13.33Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
13.33Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
13.33Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
13.33Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
13.33Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
13.33Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.33Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.33Single8GNGIstradefylline8GNG-A2A-Istradefylline
13.33Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
13.33Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
13.33Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
13.33Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
13.33Single8IWESpermidine8IWE-TA9-Spermidine
13.33Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
13.33Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
13.33Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
13.33Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
13.33Single8U4PAMD31008U4P-CXCR4-AMD3100-Gi1/β1/γ2
13.33Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
13.33Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
13.33Single8Y0HVUF114188Y0H-CXCR3-VUF11418
13.33Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go/β1/γ2
13.33Single8YYWAlpha-ketoglutarate8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
13.33Single8YYWAlpha-ketoglutarate8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
13.33Single9EEAAdenosine9EEA-A2A-Adenosine-Gs/β1/γ2
13.33Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
13.33Single9KPESA09KPE-TAS2R16-SA0-Gi1/β1/γ2
13.33Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
13.33Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
13.33Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
13.33Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
13.33Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
13.33Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
13.16Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
13.16Single7SK5CXCL127SK5-ACKR3-CXCL12
13.16Single7XNACYN1548067XNA-SST2-CYN154806
13.16Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
13.16Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
13.16Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
13.16Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
13.16Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
13.16Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
12.90Single3REYXAC3REY-A2A-XAC
12.90Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
12.90Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
12.90Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
12.90Single5IU7Q274563465IU7-A2A-Q27456346-Na
12.90Single5IUBQ274563445IUB-A2A-Q27456344-Na
12.90Single5JTBZM-2413855JTB-A2A-ZM-241385
12.90Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
12.90Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
12.90Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
12.90Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
12.90Single6AQFZM-2413856AQF-A2A-ZM-241385
12.90Single6FFIMMPEP6FFI-mGlu5-MMPEP
12.90Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
12.90Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
12.90Single6MH8ZM-2413856MH8-A2A-ZM-241385
12.90Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
12.90Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
12.90Single6TP3Nemorexant6TP3-OX1-Nemorexant
12.90Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
12.90Single6V9SGTPL114036V9S-OX1-GTPL11403
12.90Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
12.90Single7AROLUF58337ARO-A2A-LUF5833-Na
12.90Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
12.90Single7T32ZM-2413857T32-A2A-ZM-241385
12.90Single7T94LY21196207T94-M2-Acetylcholine-LY2119620-chim(NtGi1-Go)/β1/γ2
12.90Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
12.90Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
12.90Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
12.90Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
12.90Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
12.90Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
12.90Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
12.90Single8IHKAcifran8IHK-HCA3-Acifran
12.90Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
12.90Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
12.90Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
12.90Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
12.90Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
12.90Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
12.90Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
12.90Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
12.90Single8Y6YGLPG09748Y6Y-FFA2-GLPG0974
12.90Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
12.90Single8ZPNAMD31008ZPN-CXCR4-AMD3100
12.90Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
12.90Single9JMDAzithromycin9JMD-Motilin-Azithromycin-chim(Gs-CtGq)/β1/γ2
12.90Single9M2FNeuropeptide FF9M2F-NPFF1-Neuropeptide FF-Gi1/β1/γ2
12.90Consensusa2_offOrthosteric Liganda2a_off
12.90Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
12.90Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
12.82Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
12.82Single6W25SHU91196W25-MC4-SHU9119-Ca
12.82Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
12.82Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
12.82Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.82Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
12.82Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
12.82Single8W8YGamma-MSH8W8Y-MC3-γ-MSH-Ca-Gs/β1/γ2
12.82Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
12.82Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
12.82Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
12.82Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
12.50Single3EMLZM-2413853EML-A2A-ZM-241385
12.50Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
12.50Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
12.50Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
12.50Single5IU8Q274563475IU8-A2A-Q27456347-Na
12.50Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
12.50Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
12.50Single5T04Neurotensin5T04-NTS1-Neurotensin
12.50Single5UENDU1725UEN-A1-DU172
12.50Single5UIGCmpd-15UIG-A2A-Cmpd-1
12.50Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
12.50Single6D27CAY104716D27-DP2-CAY10471
12.50Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
12.50Single6FFHFenobam6FFH-mGlu5-Fenobam
12.50Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
12.50Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
12.50Single6GPSMK08126GPS-CCR2-MK0812
12.50Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
12.50Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
12.50Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
12.50Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
12.50Single6PS1Timolol6PS1-β2-Timolol
12.50Single6S0LZM-2413856S0L-A2A-ZM-241385
12.50Single6TOTLemborexant6TOT-OX1-Lemborexant
12.50Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Single6XBM5LWE6XBM-SMO-5LWE-Gi1/β1/γ2
12.50Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
12.50Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
12.50Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
12.50Single7PYRPSB-21157PYR-A2A-PSB-2115
12.50Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
12.50Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
12.50Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
12.50Single7UL4Alvimopan7UL4-μ-Alvimopan
12.50Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
12.50Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
12.50Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
12.50Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
12.50Single7YXAONO-54306087YXA-S1P5-ONO-5430608
12.50Single8CU6LJ-45178CU6-A2A-LJ-4517
12.50Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
12.50Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
12.50Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
12.50Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
12.50Single8PJKST1718PJK-5-HT1A-ST171-Gi1/β1/γ1
12.50Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
12.50Single8T1WCVN4248T1W-GPR6-CVN424
12.50Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
12.50Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
12.50Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
12.50Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
12.50Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
12.50Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
12.50Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
12.50Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
12.50Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
12.50Single8ZYYNeurotensin peptide 8-138ZYY-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
12.50Single9JEAAtropine9JEA-M1-Atropine
12.50Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
12.50Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
12.50Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
12.50Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
12.50Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
12.50Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
12.50Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
12.50Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
12.50Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
12.50Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
12.20Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
12.20Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
12.20Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
12.20Single8ZRTET-18ZRT-ETB-ET-1
12.12Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
12.12Single5IUAQ274563485IUA-A2A-Q27456348-Na
12.12Single5N2SPSB365N2S-A1-PSB36
12.12Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
12.12Single6D26Fevipiprant6D26-DP2-Fevipiprant
12.12Single6GPXMK08126GPX-CCR2-MK0812
12.12Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
12.12Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
12.12Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
12.12Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
12.12Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
12.12Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
12.12Single6S0QZM-2413856S0Q-A2A-ZM-241385
12.12Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
12.12Single6TP6Filorexant6TP6-OX1-Filorexant
12.12Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
12.12Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
12.12Single7C4SS1P7C4S-S1P3-S1P
12.12Single7C61Ergotamine7C61-5-HT1B-Ergotamine
12.12Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
12.12Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
12.12Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
12.12Single7SINNPS-21437SIN-CaS-NPS-2143
12.12Single7SINNPS-21437SIN-CaS-NPS-2143
12.12Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
12.12Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
12.12Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
12.12Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
12.12Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.12Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
12.12Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
12.12Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
12.12Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
12.12Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
12.12Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
12.12Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
12.12Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
12.12Single8GNEKW-63568GNE-A2A-KW-6356-Na
12.12Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
12.12Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
12.12Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
12.12Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
12.12Single8TF5Oleic acid8TF5-GPR6-Oleic acid
12.12Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
12.12Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
12.12Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
12.12Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
12.12Single8ZVZBW245C8ZVZ-DP1-BW245C-Gs/β1/γ2
12.12Single9DYDAsenapine9DYD-5-HT1A-Asenapine-Go/β1/γ2
12.12Single9DYFAsenapine9DYF-5-HT1A-Asenapine-Gi1/β1/γ2
12.12Single9F33FOB02-04A9F33-D3-FOB02-04A-Go/β1/γ2
12.12Single9HC04YI9HC0-mGlu5-4YI
12.12Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
12.12Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
12.12Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
12.12Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
12.12Consensusadenosine_offOrthosteric Liganda1_off a2_off
12.12Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
12.12Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
12.12Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
12.12Consensusdp_offOrthosteric Liganddp2_off
12.12Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
12.12Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
12.12Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
12.12Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.12Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.12Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
12.12Consensustrace-amine_onOrthosteric Ligandta1_on
11.90Single7SK3CXCL127SK3-ACKR3-CXCL12
11.90Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
11.76Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
11.76Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
11.76Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
11.76Single4U15Tiotropium4U15-M3-Tiotropium
11.76Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
11.76Single5V54Methiothepin5V54-5-HT1B-Methiothepin
11.76Single5XR8AM8415XR8-CB1-AM841
11.76Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
11.76Single6OL9Tiotropium6OL9-M5-Tiotropium
11.76Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
11.76Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
11.76Single7F1TMIP-1a7F1T-CCR5-MIP-1a
11.76Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
11.76Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
11.76Single7PX4PSB-21137PX4-A2A-PSB-2113
11.76Single7R0CAVP7R0C-V2-AVP-Arrestin2
11.76Single7T9NDPPC7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
11.76Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
11.76Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
11.76Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
11.76Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
11.76Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
11.76Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
11.76Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
11.76Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
11.76Single8EA0Iperoxo8EA0-M3-Iperoxo
11.76Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
11.76Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.76Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
11.76Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
11.76Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
11.76Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
11.76Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
11.76Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
11.76Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
11.76Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
11.76Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
11.76Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
11.76Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
11.76Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
11.76Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
11.76Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
11.76Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
11.76Single8ZW0PGD28ZW0-DP1-PGD2-Gs/β1/γ2
11.76Single8ZWFJR14a8ZWF-C3aB-JR14a
11.76Single9AS9RS130-1809AS9-5-HT2A-RS130-180
11.76Single9ASARS130-1809ASA-5-HT2A-RS130-180-chim(NtGi1-Gs-CtGq)/β1/γ2
11.76Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
11.76Single9EGOYVF9EGO-CB1-YVF-Gi1/β1/γ2
11.76Single9IK9SST analogue9IK9-SST1-SST analogue-Gi1/β1/γ2
11.76Single9UY3Anamorelin9UY3-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
11.76Consensus5ht1_offOrthosteric Ligand5ht1b_off
11.76Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
11.76Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
11.76Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
11.76Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
11.76Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
11.76Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
11.76Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
11.76Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
11.76Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
11.76Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
11.63Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
11.63Single8W8WAlpha-MSH8W8W-MC3-α-MSH-Ca-Gs/β1/γ2
11.43Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
11.43Single3D4STimolol3D4S-β2-Timolol
11.43Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
11.43Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
11.43Single5CXVTiotropium5CXV-M1-Tiotropium
11.43Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
11.43Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
11.43Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
11.43Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
11.43Single6ZG4HTL00099366ZG4-M1-HTL0009936
11.43Single7DFPSpiperone7DFP-D2-Spiperone
11.43Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
11.43Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
11.43Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
11.43Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
11.43Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
11.43Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
11.43Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
11.43Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
11.43Single7YITNalfurafine7YIT-κ-Nalfurafine
11.43Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
11.43Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.43Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
11.43Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
11.43Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
11.43Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
11.43Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
11.43Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
11.43Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
11.43Single8JJ8Formoterol8JJ8-β2-Formoterol
11.43Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
11.43Single8JWY2-1188JWY-A2A-2-118
11.43Single8JWZAB9288JWZ-A2A-AB928-Na
11.43Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
11.43Single8XQJJN2418XQJ-Apelin-JN241
11.43Single9AU0BW245C9AU0-DP1-BW245C-Gs/β1/γ2
11.43Single9DGIZ85267113509DGI-CB1-Z8526711350
11.43Single9GGGI-BOP9GGG-TXA2-I-BOP-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.43Single9GL2Befiradol9GL2-5-HT1A-Befiradol-Gs/β1/γ2
11.43Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
11.43Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
11.43Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
11.43Consensusalpha1_offOrthosteric Ligandalpha1a_off
11.43Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
11.43Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
11.43Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
11.43Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
11.43Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
11.43Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
11.43Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
11.43Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
11.43Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
11.43Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
11.43Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
11.43Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
11.36Single6IGLIRL16206IGL-ETB-IRL1620
11.36Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
11.36Single8IY6Endothelin-18IY6-ETB-Endothelin-1
11.11Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
11.11Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
11.11Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
11.11Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
11.11Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
11.11Single5CGDHTL142425CGD-mGlu5-HTL14242
11.11Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
11.11Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
11.11Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
11.11Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
11.11Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
11.11Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
11.11Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
11.11Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
11.11Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
11.11Single7UM4AS26747237UM4-5-HT5A-AS2674723
11.11Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
11.11Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
11.11Single7XKDBeta-Hydroxyandrosterone7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
11.11Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
11.11Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.11Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
11.11Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
11.11Single8HS2Fab0468HS2-GPR20-Fab046
11.11Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
11.11Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
11.11Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
11.11Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
11.11Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
11.11Single8PWNTheophylline8PWN-A2A-Theophylline
11.11Single8S2TIsoprenaline8S2T-β1-Isoprenaline-chim(NtGi1-Gs)/β1/γ2
11.11Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
11.11Single8X9S5alpha-DHT8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
11.11Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
11.11Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
11.11Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single8XVUCXCL28XVU-CXCR2-CXCL2
11.11Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
11.11Single8ZPLHF511168ZPL-CXCR4-HF51116
11.11Single9AS02-bromo-LSD9AS0-5-HT2A-2-bromo-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
11.11Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
11.11Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
11.11Consensusfp-alpha_onOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
11.11Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
11.11Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
10.87Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
10.81Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
10.81Single6KNMJN241-96KNM-Apelin-JN241-9
10.81Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
10.81Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
10.81Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
10.81Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.81Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
10.81Single7XN9L-054,5227XN9-SST2-L-054,522
10.81Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
10.81Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
10.81Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
10.81Single8X5YAstemizole8X5Y-H1-Astemizole
10.81Single8XQJJN2418XQJ-Apelin-JN241
10.81Single8Y72Peptide8Y72-μ-Peptide-BMS-986122-Gi1/β1/γ2
10.81Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
10.81Single9CGKC5-Quino9CGK-δ-C5-Quino-Gi1/β1/γ2
10.81Single9JH6C20:0 Ceramide9JH6-CysLT2-C20:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
10.81Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
10.81Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
10.71Single3RFMCaffeine3RFM-A2A-Caffeine
10.71Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
10.71Single6XBM5LWE6XBM-SMO-5LWE-Gi1/β1/γ2
10.71Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
10.71Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Gi1/β1/γ2
10.71Single8Y02Retinal8Y02-OPN1SW-Retinal-Gi1/β1/γ2
10.71Consensusp2y_offOrthosteric Ligandp2y1_off
10.53Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
10.53Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
10.53Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
10.53Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
10.53Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
10.53Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
10.53Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
10.53Single8PKMBefiradol8PKM-5-HT1A-Befiradol-Gi1/β1/γ1
10.53Single8WKYPG-9348WKY-MC4-PG-934
10.53Single8ZBJSomatostatin-148ZBJ-SST5-Somatostatin-14-Gi1/β1/γ2
10.53Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
10.53Single9M4TSilodosin9M4T-Alpha1A-Silodosin
10.53Consensussomatostatin_offOrthosteric Ligandsst2_off
10.34Single3OE6IT1t3OE6-CXCR4-IT1t
10.34Single3UZAGTPL92363UZA-A2A-GTPL9236
10.34Single4XNWMRS25004XNW-P2Y1-MRS2500
10.34Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
10.34Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
10.34Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
10.34Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
10.34Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.34Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
10.34Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
10.34Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
10.34Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
10.34Single9JHJC18:0 Ceramide9JHJ-FPR2-ALX-C18:0 Ceramide-Gi1/β1/γ2
10.34Single9LRCHistamine9LRC-H4-Histamine
10.34Single9LREHistamine9LRE-H4-Histamine-Gi1/β1/γ2
10.34Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
10.34Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
10.34Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
10.34Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
10.34Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
10.34Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
10.26Single6HLOAprepitant6HLO-NK1-Aprepitant
10.26Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
10.26Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
10.26Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
10.26Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
10.26Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
10.26Single9IK8SST analogue9IK8-SST1-SST analogue-Gi1/β1/γ2
10.26Single9IQRMuscarinic toxin 39IQR-α2a-Muscarinic toxin 3
10.26Single9J0FNADH9J0F-P2Y14-NADH-Gi1/β1/γ2
10.26Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
10.26Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
10.26Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
10.00Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
10.00Single4O9RCyclopamine4O9R-SMO-Cyclopamine
10.00Single5L7IVismodegib5L7I-SMO-Vismodegib
10.00Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
10.00Single6PT2KGCHM076PT2-δ-KGCHM07
10.00Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
10.00Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
10.00Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
10.00Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
10.00Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
10.00Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
10.00Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
10.00Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
10.00Single8YKDDehydroepiandrosterone8YKD-ADGRG2-Dehydroepiandrosterone-chim(NtGi1-Gs)/β1/γ2
10.00Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
10.00Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
10.00Single8YN7Immethridine8YN7-H3-Immethridine-Go/β1/γ2
10.00Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
10.00Single9B9Y7DY9B9Y-CB1-7DY
10.00Single9EPRRetinal9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
10.00Single9IZDCHBA9IZD-HCA1-CHBA-Gi1/β1/γ2
10.00Single9M1OMorphine-Modulating Neuropeptide B9M1O-NPFF2-Morphine-Modulating Neuropeptide B-Gi1/β1/γ2
10.00Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg4_on
10.00Consensusadgrg_on_gpOrthosteric Ligandadgrg2_on_gp adgrg4_on_gp
10.00Consensusgq_nucleotideOrthosteric Ligandgq_p2y
10.00Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
10.00Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
10.00Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
10.00Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
9.76Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
9.76Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
9.76Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
9.76Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
9.76Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
9.76Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
9.76Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
9.76Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
9.76Consensusvasop-oxy_onOrthosteric Ligandv2_on
9.76Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
9.68Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
9.68Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
9.68Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
9.68Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
9.68Single4QINSAG1.54QIN-SMO-SAG1.5
9.68Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
9.68Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
9.68Single5WS3EMPA5WS3-OX2-EMPA
9.68Single6AKXA4R6AKX-CCR5-A4R
9.68Single6AKYMaraviroc6AKY-CCR5-Maraviroc
9.68Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
9.68Single6ME9Ramelteon6ME9-MT2-Ramelteon
9.68Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
9.68Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
9.68Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
9.68Single7BR3Elagolix7BR3-GnRH1-Elagolix
9.68Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
9.68Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
9.68Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
9.68Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
9.68Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
9.68Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
9.68Single7VVOPTH7VVO-PTH1-PTH-Gs/β1/γ2
9.68Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
9.68Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
9.68Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
9.68Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
9.68Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.68Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
9.68Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
9.68Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
9.68Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
9.68Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
9.68Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
9.68Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
9.68Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
9.68Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
9.68Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.68Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
9.68Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
9.68Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ2
9.68Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
9.68Single9H2XA1IR19H2X-A2A-A1IR1-Na
9.68Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
9.68Single9K6LSA09K6L-TAS2R16-SA0-Gi2/β1/γ2
9.68Consensusalpha2_offOrthosteric Ligandalpha2c_off
9.68Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
9.68Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
9.68Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
9.68Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
9.68Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
9.68Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
9.68Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
9.68Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
9.68Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
9.68Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
9.68Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
9.68Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
9.68Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
9.52Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
9.52Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
9.52Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.52Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
9.38Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
9.38Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
9.38Single4MBSMaraviroc4MBS-CCR5-Maraviroc
9.38Single4ZJCSB-6740424ZJC-OX1-SB-674042
9.38Single5UVIZM-2413855UVI-A2A-ZM-241385
9.38Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
9.38Single6KUXRS-799486KUX-α2a-RS-79948
9.38Single6PS0S-Carazolol6PS0-β2-S-Carazolol
9.38Single6PS4ICI118-5516PS4-β2-ICI118-551
9.38Single6TPGEMPA6TPG-OX2-EMPA
9.38Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
9.38Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
9.38Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
9.38Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
9.38Single6ZG9GSK10347026ZG9-M1-GSK1034702
9.38Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
9.38Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
9.38Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
9.38Single7F61PF-036547467F61-H3-PF-03654746
9.38Single7T94Acetylcholine7T94-M2-Acetylcholine-LY2119620-chim(NtGi1-Go)/β1/γ2
9.38Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
9.38Single7UL3Famotidine7UL3-H2-Famotidine
9.38Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
9.38Single7UTZDPPC7UTZ-TSH-TR1402-DPPC-Gs/β1/γ2
9.38Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
9.38Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
9.38Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
9.38Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
9.38Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
9.38Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
9.38Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
9.38Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
9.38Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
9.38Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.38Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
9.38Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
9.38Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
9.38Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
9.38Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
9.38Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
9.38Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
9.38Single8RLNLUF58348RLN-A2A-LUF5834
9.38Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
9.38Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.38Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.38Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
9.38Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
9.38Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
9.38Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
9.38Single8YRGFospropofol8YRG-MRGPRX4-Fospropofol-chim(NtGi1-Gs-CtGq)/β1/γ2
9.38Single9AS5Mescaline9AS5-5-HT2A-Mescaline
9.38Single9AS6Mescaline9AS6-5-HT2A-Mescaline-chim(NtGi1-Gs-CtGq)/β1/γ2
9.38Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
9.38Single9BA0A1AKN9BA0-CB1-A1AKN
9.38Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
9.38Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
9.38Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
9.38Consensusgrh_offOrthosteric Ligandgnrh1_off
9.38Consensusopsins_offOrthosteric Ligandrhodopsin_off
9.38Consensussensory_offOrthosteric Ligandopsins_off
9.30Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
9.30Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
9.09Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
9.09Single2Y01Dobutamine2Y01-β1-Dobutamine
9.09Single2Y04Salbutamol2Y04-β1-Salbutamol
9.09Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
9.09Single3NY8ICI118-5513NY8-β2-ICI118-551
9.09Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
9.09Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
9.09Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
9.09Single4GBRS-Carazolol4GBR-β2-S-Carazolol
9.09Single4MQSIperoxo4MQS-M2-Iperoxo
9.09Single4QIMANTA XV4QIM-SMO-ANTA XV
9.09Single4QKX35V4QKX-β2-35V
9.09Single4U14Tiotropium4U14-M3-Tiotropium
9.09Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
9.09Single5DHHSB-6121115DHH-NOP-SB-612111
9.09Single5DSGTiotropium5DSG-M4-Tiotropium
9.09Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
9.09Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
9.09Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
9.09Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
9.09Single6H7MSalbutamol6H7M-β1-Salbutamol
9.09Single6IIVDaltroban6IIV-TXA2-Daltroban
9.09Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
9.09Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
9.09Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
9.09Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
9.09Single7BU7BI1671077BU7-β1-BI167107
9.09Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
9.09Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
9.09Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
9.09Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
9.09Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
9.09Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
9.09Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
9.09Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
9.09Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
9.09Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
9.09Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
9.09Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
9.09Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
9.09Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
9.09Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
9.09Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
9.09Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
9.09Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
9.09Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.09Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.09Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.09Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.09Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.09Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.09Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.09Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.09Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.09Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.09Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
9.09Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
9.09Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
9.09Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
9.09Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
9.09Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
9.09Single8JJOAlprenolol8JJO-β2-Alprenolol
9.09Single8JXRLSD8JXR-D1-LSD
9.09Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
9.09Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
9.09Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
9.09Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
9.09Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.09Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.09Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
9.09Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
9.09Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
9.09Single8YN8Proxyfan8YN8-H3-Proxyfan-Go/β1/γ2
9.09Single9AS1DMT9AS1-5-HT2A-DMT
9.09Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
9.09Single9CHXS-Carazolol9CHX-β2-S-Carazolol
9.09Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
9.09Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
9.09Single9IMATalquetamab9IMA-GPRC5D-Talquetamab
9.09Single9IYAONO-97105319IYA-GPR55-ONO-9710531
9.09Single9JGKBalovaptan9JGK-5-HT2B-Balovaptan
9.09Single9PQD(6m)-1-methyl-6-(1,2,5,6-tetrahydropyridin-3-yl)-1h-indole9PQD-α2a-(6m)-1-methyl-6-(1,2,5,6-tetrahydropyridin-3-yl)-1h-indole
9.09Consensus5ht5_onOrthosteric Ligand5ht5a_on
9.09Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
9.09Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
9.09Consensusalpha2_onOrthosteric Ligandalpha2b_on
9.09Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
9.09Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
9.09Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
9.09Consensusdopamine_offOrthosteric Ligandd2_off d3_off
9.09Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
9.09Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
9.09Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
9.09Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
9.09Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
8.89Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
8.89Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
8.89Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
8.82Single2RH1S-Carazolol2RH1-β2-S-Carazolol
8.82Single2Y00Dobutamine2Y00-β1-Dobutamine
8.82Single2Y03Isoprenaline2Y03-β1-Isoprenaline
8.82Single2YCWS-Carazolol2YCW-β1-S-Carazolol
8.82Single4JKVTaladegib4JKV-SMO-Taladegib
8.82Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
8.82Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
8.82Single5CGCHTL142425CGC-mGlu5-HTL14242
8.82Single5D6LS-Carazolol5D6L-β2-S-Carazolol
8.82Single5JQHS-Carazolol5JQH-β2-S-Carazolol
8.82Single5WIUNemonapride5WIU-D4-Nemonapride
8.82Single5WIVNemonapride5WIV-D4-Nemonapride-Na
8.82Single5WQCEMPA5WQC-OX2-EMPA
8.82Single5X7DS-Carazolol5X7D-β2-S-Carazolol-Cmpd-15
8.82Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
8.82Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
8.82Single6LUQHaloperidol6LUQ-D2-Haloperidol
8.82Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
8.82Single6PS6Timolol6PS6-β2-Timolol
8.82Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
8.82Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
8.82Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
8.82Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
8.82Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
8.82Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
8.82Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
8.82Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
8.82Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
8.82Single7W41PD1762527W41-BB2-PD176252
8.82Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
8.82Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
8.82Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.82Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
8.82Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
8.82Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
8.82Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
8.82Single8JXSPF-61428JXS-D1-PF-6142
8.82Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
8.82Single8QOTNanobody-E8QOT-μ-Nanobody-E
8.82Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
8.82Single8ZMFA1L108ZMF-5-HT2C-A1L10
8.82Single9ARZ2-bromo-LSD9ARZ-5-HT2A-2-bromo-LSD
8.82Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
8.82Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
8.82Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
8.82Single9F34FOB02-04A9F34-D3-FOB02-04A-Go/β1/γ2
8.82Single9GE2ML1849GE2-GPR55-ML184-chim(NtGi1-G13)/β1/γ2
8.82Single9I52A1IZU9I52-D1-A1IZU-Gs/β1/γ2
8.82Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
8.82Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
8.82Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
8.82Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
8.82Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
8.82Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
8.82Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
8.82Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
8.82Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
8.82Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
8.82Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
8.82Consensusamine_offonOrthosteric Ligandamine_off amine_on
8.82Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
8.82Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
8.82Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
8.82Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
8.82Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
8.82Consensusbombesin_offOrthosteric Ligandbb2_off
8.82Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
8.82Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
8.82Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
8.82Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
8.82Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
8.82Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
8.82Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
8.57Single3P0GBI1671073P0G-β2-BI167107
8.57Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
8.57Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
8.57Single4DJHJDTic4DJH-κ-JDTic
8.57Single5D5AS-Carazolol5D5A-β2-S-Carazolol
8.57Single5D5BS-Carazolol5D5B-β2-S-Carazolol
8.57Single5TZRMK86665TZR-FFA1-MK8666
8.57Single5V56TC1145V56-SMO-TC114
8.57Single5V57TC1145V57-SMO-TC114
8.57Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
8.57Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
8.57Single6H7JIsoprenaline6H7J-β1-Isoprenaline
8.57Single6J21Aprepitant6J21-NK1-Aprepitant
8.57Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
8.57Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
8.57Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
8.57Single6TQ7SB-3348676TQ7-OX1-SB-334867
8.57Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
8.57Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
8.57Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
8.57Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
8.57Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
8.57Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
8.57Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
8.57Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
8.57Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
8.57Single8GDBPGE28GDB-EP4-PGE2-Gs/β1/γ2
8.57Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
8.57Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
8.57Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
8.57Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
8.57Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
8.57Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
8.57Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
8.57Single8Y73Peptide8Y73-μ-Peptide-MPAM-15-Gi1/β1/γ2
8.57Single8YNTSNAP-948478YNT-MCH1-SNAP-94847
8.57Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
8.57Single9BJKNaloxone9BJK-μ-Naloxone-NAM
8.57Single9I54A1IZV9I54-D1-A1IZV-Gs/β1/γ2
8.57Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
8.57Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
8.57Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
8.57Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
8.57Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
8.57Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
8.57Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
8.57Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
8.57Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
8.57Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
8.57Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
8.57Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
8.51Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
8.33Single4AMIBucindolol4AMI-β1-Bucindolol
8.33Single4LDEBI1671074LDE-β2-BI167107
8.33Single4RWADIPP-NH24RWA-δ-DIPP-NH2
8.33Single5TZYMK8666; AP85TZY-FFA1-MK8666; AP8
8.33Single6CM4Risperidone6CM4-D2-Risperidone
8.33Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
8.33Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
8.33Single6MXTSalmeterol6MXT-β2-Salmeterol
8.33Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
8.33Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
8.33Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
8.33Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
8.33Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
8.33Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
8.33Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
8.33Single8JJLOlodaterol8JJL-β2-Olodaterol
8.33Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
8.33Single8XWACXCL18XWA-CXCR2-CXCL1
8.33Single8XWMCXCL68XWM-CXCR2-CXCL6
8.33Single8XWSCXCL58XWS-CXCR2-CXCL5
8.33Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
8.33Single9M4QDoxazosin9M4Q-Alpha1A-Doxazosin
8.33Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
8.33Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
8.33Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
8.33Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
8.33Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
8.11Single5X93K-87945X93-ETB-K-8794
8.11Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
8.11Single6H7LDobutamine6H7L-β1-Dobutamine
8.11Single6IBLArformoterol6IBL-β1-Arformoterol
8.11Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
8.11Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
8.11Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
8.11Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
8.11Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
8.11Single8XVJMacitentan8XVJ-ETA-Macitentan
8.11Single8XWFCXCL38XWF-CXCR2-CXCL3
8.11Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
8.11Single9GG5U466199GG5-TXA2-U46619-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.11Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
8.11Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
8.11Consensuschemerin_onOrthosteric Ligandcml1_on
8.11Consensusendothelin_offOrthosteric Ligandetb_off
8.11Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
8.11Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
8.00Consensusclass-b2_onOrthosteric Ligandadgrg_on adgrf_on adgrl_on adgre_on adgrd_on
8.00Consensusclass-b2_on_gpOrthosteric Ligandadgrg_on_gp adgrf_on_gp adgrl_on_gp adgre_on_gp adgrd_on_gp
7.89Single6PT3DPI-2876PT3-δ-DPI-287
7.89Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
7.89Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
7.89Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
7.89Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
7.89Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
7.89Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
7.69Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
7.69Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
7.69Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
7.69Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
7.69Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
7.69Single9J0IUDP-Glucuronic acid9J0I-P2Y14-UDP-Glucuronic acid-Gi1/β1/γ2
7.69Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
7.69Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
7.50Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
7.41Single5MZPCaffeine5MZP-A2A-Caffeine-Na
7.41Single8GEJConstrained Epinephrine8GEJ-β2-Constrained Epinephrine-Gs/β1/γ2
7.14Single6VCBLSN31604406VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
7.14Single7V68LY21196207V68-M4-Iperoxo-LY2119620-Gi1/β1/γ2
7.14Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
6.90Single2HPYAll-trans-Retinal2HPY-Rhodopsin-All-trans-Retinal
6.90Single3OE8IT1t3OE8-CXCR4-IT1t
6.90Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
6.90Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.90Single8WC5Tetramethylammonium Ion8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
6.90Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
6.90Consensussensory_onOrthosteric Ligandopsins_on
6.67Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
6.67Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
6.67Single3PQRAll-trans-Retinal3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
6.67Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
6.67Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
6.67Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
6.67Single6ME5Agomelatine6ME5-MT1-Agomelatine
6.67Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
6.67Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
6.67Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
6.67Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
6.67Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
6.67Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
6.67Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
6.67Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
6.67Single8IW72-Phenylethylamine8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
6.67Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
6.67Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
6.67Single9KDFRES-701-39KDF-ETB-RES-701-3
6.67Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
6.67Consensusgi_sensoryOrthosteric Ligandgi_opsins
6.67Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
6.67Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
6.45Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
6.45Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
6.45Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
6.45Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
6.45Single3PBLEticlopride3PBL-D3-Eticlopride
6.45Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
6.45Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
6.45Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
6.45Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
6.45Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
6.45Single7SRQLSD7SRQ-5-HT2B-LSD
6.45Single7V68Iperoxo7V68-M4-Iperoxo-LY2119620-Gi1/β1/γ2
6.45Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
6.45Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
6.45Single7XP6Strychnine7XP6-TAS2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
6.45Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
6.45Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
6.45Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
6.45Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
6.45Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
6.45Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.45Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
6.45Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
6.45Single8ZYUNeurotensin peptide 8-138ZYU-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
6.45Single9E7RGB889E7R-PAR2-GB88-chim(NtGi1L-Gs-CtGq)/β1/γ2
6.45Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
6.45Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
6.45Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
6.38Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
6.25Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
6.25Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
6.25Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
6.25Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
6.25Single4XNVBPTU4XNV-P2Y1-BPTU
6.25Single6B73MP11046B73-κ-MP1104
6.25Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
6.25Single6ME2Ramelteon6ME2-MT1-Ramelteon
6.25Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
6.25Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
6.25Single6TODEMPA6TOD-OX1-EMPA-Na
6.25Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
6.25Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
6.25Single7F8ULintitript7F8U-CCKA-Lintitript
6.25Single7F8YDevazepide7F8Y-CCKA-Devazepide
6.25Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
6.25Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.25Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
6.25Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
6.25Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
6.25Single7XRRLemborexant7XRR-OX2-Lemborexant
6.25Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
6.25Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
6.25Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
6.25Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
6.25Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
6.25Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.25Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
6.25Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
6.25Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
6.25Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
6.25Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
6.25Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
6.25Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
6.25Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
6.25Consensusorexin_offOrthosteric Ligandox2_off ox1_off
6.25Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
6.25Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
6.06Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
6.06Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
6.06Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
6.06Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
6.06Single6IQLL7458706IQL-D4-L745870
6.06Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
6.06Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
6.06Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
6.06Single6PS5S-Propranolol6PS5-β2-S-Propranolol
6.06Single6VI4JDTic6VI4-κ-JDTic
6.06Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
6.06Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
6.06Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
6.06Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
6.06Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
6.06Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
6.06Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
6.06Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
6.06Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.06Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
6.06Single7VV6C48/807VV6-MRGPRX2-C48/80
6.06Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
6.06Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
6.06Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
6.06Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.06Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
6.06Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
6.06Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
6.06Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
6.06Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
6.06Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
6.06Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
6.06Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
6.06Single8K9LDamgo8K9L-μ-Damgo-BMS-986122-Gi3/β1/γ1
6.06Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.06Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.06Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
6.06Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
6.06Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
6.06Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
6.06Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
6.06Single9AS3LSD9AS3-5-HT2A-LSD
6.06Single9AS4LSD9AS4-5-HT2A-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
6.06Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
6.06Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
6.06Single9IXXLTD49IXX-CysLT2-LTD4-chim(NtGi1-Gs-CtGq)/β1/γ2
6.06Single9KPDSA09KPD-TAS2R16-SA0-chim(Gs-CtGt3)/β1/γ2
6.06Single9LRDHistamine9LRD-H1-Histamine-Gi1/β1/γ2
6.06Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
6.06Consensusalpha1_onOrthosteric Ligandalpha1a_on
6.06Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
6.06Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
6.06Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
6.06Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
6.06Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
6.06Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
5.88Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
5.88Single2Y02Carmoterol2Y02-β1-Carmoterol
5.88Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
5.88Single4DAJTiotropium4DAJ-M3-Tiotropium
5.88Single4EJ4Naltrindole4EJ4-δ-Naltrindole
5.88Single5DHGC-355DHG-NOP-C-35
5.88Single6DRXLisuride6DRX-5-HT2B-Lisuride
5.88Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
5.88Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
5.88Single7F83PF-051904577F83-Ghrelin-PF-05190457
5.88Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
5.88Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
5.88Single7WC7Lisuride7WC7-5-HT2A-Lisuride
5.88Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
5.88Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
5.88Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
5.88Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
5.88Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.88Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
5.88Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
5.88Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
5.88Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
5.88Single8TH3AT118-H Nanobody8TH3-AT1-AT118-H Nanobody
5.88Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
5.88Single8X63Mepyramine8X63-H1-Mepyramine
5.88Single8X64Desloratadine8X64-H1-Desloratadine
5.88Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
5.88Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
5.88Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
5.88Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
5.88Single9PLNN-(5-methylnaphthalen-1-yl)pyridin-4-amine9PLN-α2a-N-(5-methylnaphthalen-1-yl)pyridin-4-amine
5.88Single9PLON-(5-methylnaphthalen-1-yl)pyridin-4-amine9PLO-α2a-N-(5-methylnaphthalen-1-yl)pyridin-4-amine-Go/β1/γ2
5.88Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
5.88Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
5.88Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
5.88Consensuscck_offOrthosteric Ligandccka_off
5.88Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
5.88Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
5.88Consensushistamine_offOrthosteric Ligandh1_off
5.71Single4NTJAZD12834NTJ-P2Y12-AZD1283
5.71Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
5.71Single5TVNLSD5TVN-5-HT2B-LSD
5.71Single6E67BI1671076E67-β2-BI167107-Gs(CT)
5.71Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
5.71Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
5.71Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
5.71Single7WC6LSD7WC6-5-HT2A-LSD
5.71Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.71Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
5.71Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
5.71Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
5.71Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
5.71Single9ARYSerotonin9ARY-5-HT2A-Serotonin-chim(NtGi1-Gs-CtGq)/β1/γ2
5.71Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
5.71Single9HAPTolvaptan9HAP-V2-Tolvaptan
5.71Single9K07DSO-5a9K07-BB3-DSO-5a-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.71Single9KPFSA09KPF-TAS2R16-SA0-Gi1/β1/γ2
5.71Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
5.56Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
5.56Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
5.56Single6WGTLSD6WGT-5-HT2A-LSD
5.56Single7B6WCyclazosin7B6W-α1b-Cyclazosin
5.56Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
5.56Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
5.56Single8JD5JNJ-40411813; ADX881788JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
5.56Single8JD5JNJ-40411813; ADX881788JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
5.56Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
5.56Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
5.56Single8XVLZibotentan8XVL-ETA-Zibotentan
5.56Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
5.56Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
5.56Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
5.56Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
5.56Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
5.56Consensustachykinin_offOrthosteric Ligandnk1_off
5.41Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
5.41Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
5.41Single4PY02MeSATP4PY0-P2Y12-2MeSATP
5.41Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
5.41Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
5.41Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
5.41Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
5.41Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
5.41Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.41Single8GTMBMK-C2038GTM-CRF1-BMK-C203
5.41Single8JD3JNJ-404118138JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
5.41Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.41Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
5.41Single8Y6WTUG-13758Y6W-FFA2-TUG-1375-4-CMTB-Gi1/β1/γ2
5.41Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
5.41Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
5.41Consensusorexin_onOrthosteric Ligandox2_on
5.41Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
5.26Single6K1QIRL25006K1Q-ETB-IRL2500
5.26Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
5.26Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
5.26Single9CGJC6-Quino9CGJ-δ-C6-Quino-Gi1/β1/γ2
5.26Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
5.26Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
5.13Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
5.13Single9JF4PD1683689JF4-BB1-PD168368
5.00Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
5.00Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.00Single8IEBA1LYA8IEB-GPR156-A1LYA
5.00Single8IEIA1LYA8IEI-GPR156-A1LYA
5.00Single8IEIA1LYA8IEI-GPR156-A1LYA
5.00Single8IEPA1LYA8IEP-GPR156-A1LYA
5.00Single8IEPA1LYA8IEP-GPR156-A1LYA
4.88Single8IEBA1LYA8IEB-GPR156-A1LYA
4.65Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
4.00Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
4.00Single6D35Cholesterol6D35-SMO-Cholesterol
4.00Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
4.00Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
4.00Single6UO8SKF975416UO8-GABAB1, GABAB2-SKF97541-GS39783
4.00Single6UO9SKF975416UO9-GABAB1, GABAB2-SKF97541
4.00Single6W2XPubChem 53110426W2X-GABAB1, GABAB2-PubChem 5311042
4.00Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042
4.00Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042
4.00Single7C7QBaclofen7C7Q-GABAB1, GABAB2-Baclofen-BHFF
4.00Single7C7SCGP546267C7S-GABAB1, GABAB2-CGP54626
4.00Single7CUMCGP546267CUM-GABAB1, GABAB2-CGP54626
4.00Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
4.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
4.00Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
4.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
4.00Single7DGEQuisqualate7DGE-mGlu1; mGlu1-Quisqualate
4.00Single7DTTCa7DTT-CaS-Ca-Ca
4.00Single7DTTCa7DTT-CaS-Ca-Ca
4.00Single7DTUTryptophan7DTU-CaS-Tryptophan
4.00Single7DTUTryptophan7DTU-CaS-Tryptophan
4.00Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
4.00Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
4.00Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
4.00Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
4.00Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.00Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.00Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.00Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.00Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
4.00Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
4.00Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
4.00Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
4.00Single7EB2Baclofen7EB2-GABAB2; GABAB1-Baclofen-rac-BHFF-Gi1/β1/γ2
4.00Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
4.00Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
4.00Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
4.00Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
4.00Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
4.00Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
4.00Single7FIHhCG7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
4.00Single7FIIhCG7FII-LH-hCG-chim(NtGi1-Gs)/β1/γ2
4.00Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
4.00Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
4.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
4.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
4.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.00Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
4.00Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
4.00Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
4.00Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
4.00Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
4.00Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
4.00Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
4.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
4.00Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
4.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
4.00Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.00Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.00Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.00Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.00Single7T9NM22 Fab7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
4.00Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
4.00Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
4.00Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
4.00Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
4.00Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
4.00Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
4.00Single7XW6M22 Fab7XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
4.00Single7XW7K1-707XW7-TSH-K1-70
4.00Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
4.00Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
4.00Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
4.00Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
4.00Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
4.00Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
4.00Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
4.00Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
4.00Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
4.00Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
4.00Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
4.00Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
4.00Single8JD0Glutamate8JD0-mGlu2; mGlu3-Glutamate-NAM563
4.00Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
4.00Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
4.00Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
4.00Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
4.00Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
4.00Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
4.00Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
4.00Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
4.00Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
4.00Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
4.00Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
4.00Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
4.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
4.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
4.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
4.00Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
4.00Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
4.00Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
4.00Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
4.00Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
4.00Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
4.00Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
4.00Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
4.00Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
4.00Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
4.00Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
4.00Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
4.00Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
4.00Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
4.00Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
4.00Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
4.00Single8WG9(2S)-2-amino-4-phosphonobutanoic acid8WG9-mGlu4; mGlu2-(2S)-2-amino-4-phosphonobutanoic acid
4.00Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
4.00Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
4.00Single8WGCLY3792688WGC-mGlu4; mGlu2-LY379268
4.00Single8WGDWAG; WA68WGD-mGlu4; mGlu2-WAG; WA6
4.00Single8WGDWAG; WA68WGD-mGlu4; mGlu2-WAG; WA6
4.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
4.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
4.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.00Single8WVXNorrin8WVX-LGR4-Norrin
4.00Single8WVYNorrin8WVY-LGR4-Norrin
4.00Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
4.00Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
4.00Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
4.00Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
4.00Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
4.00Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
4.00Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
4.00Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
4.00Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
4.00Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
4.00Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
4.00Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
4.00Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
4.00Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
4.00Single8XUMR-spondin-28XUM-LGR4-R-spondin-2
4.00Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
4.00Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
4.00Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
4.00Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
4.00Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
4.00Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
4.00Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
4.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
4.00Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
4.00Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
4.00Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
4.00Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
4.00Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
4.00Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
4.00Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
4.00Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
4.00Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
4.00Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
4.00Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
4.00Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
4.00Single9KHHNorrin9KHH-LGR4-Norrin
4.00Single9S37NB219S37-LGR4-NB21
4.00Single9UTBSucralose9UTB-TAS1R2; TAS1R3-Sucralose
3.85Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
3.85Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
3.85Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
3.85Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
3.85Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
3.85Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
3.85Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
3.85Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
3.85Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
3.85Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
3.85Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
3.85Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
3.85Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
3.85Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
3.85Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
3.85Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
3.70Single7KNUCalcitonin gene-related peptide-17KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
3.70Single7T9MCS-17 Antibody7T9M-TSH-CS-17 Antibody
3.70Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
3.57Single4A4MAll-trans-Retinal4A4M-Rhodopsin-All-trans-Retinal-Gt(CT)
3.57Single5EN0All-trans-Retinal5EN0-Rhodopsin-All-trans-Retinal-Gt(CT)
3.57Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
3.57Single7FIGhCG7FIG-LH-hCG-chim(NtGi1L-Gs)/β1/γ2
3.57Single7UTZTR14027UTZ-TSH-TR1402-DPPC-Gs/β1/γ2
3.57Single7XW5TSH7XW5-TSH-TSH-ML109-Gs/β1/γ2
3.57Single7ZI0Cholesterol7ZI0-SMO-SAG-Cholesterol
3.57Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
3.57Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
3.45Single3PXOAll-trans-Retinal3PXO-Rhodopsin-All-trans-Retinal
3.45Single5DYSAll-trans-Retinal5DYS-Rhodopsin-All-trans-Retinal
3.45Single5L7DCholesterol5L7D-SMO-Cholesterol
3.45Single7T9ITSH7T9I-TSH-TSH-Gs/β1/γ2
3.45Single8I2GGlycoprotein hormones alpha chain8I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
3.45Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
3.33Single6OY9All-trans-Retinal6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
3.33Single6TQ9SB-4081246TQ9-OX1-SB-408124
3.33Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
3.33Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
3.33Single8IWM2-Phenylethylamine8IWM-TA9-2-Phenylethylamine
3.33Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
3.33Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
3.33Single9CHUNoradrenaline9CHU-β2-Noradrenaline
3.23Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
3.23Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
3.23Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
3.23Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/β1/γ2
3.23Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
3.23Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
3.23Single8J6QCompound 9n8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
3.23Single8JPSCCL78JPS-ACKR1-CCL7
3.23Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
3.23Single8XQPAristolochic acid A8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
3.23Consensus5ht2_onOrthosteric Ligand5ht2b_on
3.23Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.23Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
3.23Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
3.12Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
3.12Single6HLLCP999946HLL-NK1-CP99994
3.12Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
3.12Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
3.12Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
3.12Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
3.12Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
3.12Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.12Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
3.12Single7UL2SR486927UL2-NTS1-SR48692-Na
3.12Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
3.12Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
3.12Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.12Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
3.12Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
3.12Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/β1/γ2
3.12Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
3.12Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
3.12Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
3.12Single8YN2Histamine8YN2-H1-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
3.12Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
3.12Single9AS2DMT9AS2-5-HT2A-DMT-chim(NtGi1-Gs-CtGq)/β1/γ2
3.12Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
3.12Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
3.12Single9IXJHistamine9IXJ-H2-Histamine-Gs/β1/γ2
3.12Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
3.12Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
3.12Consensusneurotensin_offOrthosteric Ligandnts1_off
3.12Consensusnts1_offOrthosteric Ligand7UL2-NTS1-SR48692-Na
3.03Single4K5YCP-3763954K5Y-CRF1-CP-376395
3.03Single6C1QNDT95137276C1Q-C5a1-PMX53-NDT9513727
3.03Single6DS0Ly2660976DS0-5-HT2B-Ly266097
3.03Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
3.03Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
3.03Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
3.03Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
3.03Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
3.03Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
3.03Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.03Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
3.03Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
3.03Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
3.03Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.03Single8T3VDocosa-4,7,10,13,16,19-Hexaenoic acid8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.03Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
3.03Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
3.03Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
3.03Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
3.03Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
3.03Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
3.03Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.03Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
3.03Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
2.94Single3RZECidoxepin3RZE-H1-Cidoxepin
2.94Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
2.94Single6A94Zotepine6A94-5-HT2A-Zotepine
2.94Single6ZINSR486926ZIN-NTS1-SR48692
2.94Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
2.94Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
2.94Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
2.94Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
2.94Single8IYXYL-3658IYX-GPR34-YL-365
2.94Single8JD6VU03647708JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
2.94Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
2.94Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
2.94Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
2.94Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
2.94Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
2.94Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
2.94Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
2.94Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
2.94Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Gi1/β1/γ2
2.94Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
2.86Single4Z9GCP-3763954Z9G-CRF1-CP-376395
2.86Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
2.86Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
2.86Single7RBTLSN35566727RBT-GIP-Tirzepatide-LSN3556672-chim(NtGi1-Gs)/β1/γ2
2.86Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
2.86Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
2.86Single8GTIBMK-C2058GTI-CRF1-BMK-C205
2.86Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
2.86Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
2.86Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
2.86Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
2.86Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
2.86Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
2.86Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
2.86Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
2.78Single5XPRBosentan5XPR-ETB-Bosentan
2.78Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
2.78Single6HLPNetupitant6HLP-NK1-Netupitant
2.78Single6Z4SSR486926Z4S-NTS1-SR48692
2.78Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
2.78Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
2.78Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
2.78Single8GTGBMK-I1528GTG-CRF1-BMK-I152
2.78Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
2.78Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
2.70Single6J20Aprepitant6J20-NK1-Aprepitant
2.70Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
2.70Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Gi1/β1/γ1
2.63Single9CM3TUG-13759CM3-FFA2-TUG-1375-Compound 187-chim(NtGi1L-Gs-CtGq)/β1/γ2
2.56Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
2.56Single8T3OTUG-8918T3O-FFA4-TUG-891-chim(NtGi2L-Gs-CtGq)/β1/γ2
2.56Single9JH5C16:0 Ceramide9JH5-CysLT2-C16:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
2.50Single9CM7TUG-13759CM7-FFA2-TUG-1375-AZ-1729-Gi1/β1/γ2
2.50Single9NS9TUG-13759NS9-FFA2-TUG-1375-Compound 187-Gi1/β1/γ2
2.50Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
2.50Consensuskisspeptin_onOrthosteric Ligandkiss1_on
2.44Single8XFTR-spondin-28XFT-LGR4-R-spondin-2-ZNRF3
2.44Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-ZNRF3
2.44Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
2.44Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
2.44Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
2.44Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
2.33Single8WVUR-spondin-18WVU-LGR4-R-spondin-1-RNF43
2.33Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-ZNRF3
2.27Single8XFPR-spondin-28XFP-LGR4-R-spondin-2-ZNRF3
2.13Single8XFSR-spondin-28XFS-LGR4-R-spondin-2-ZNRF3

Consensus Members
Id Members
7FIN 7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
7FIY 7FIY-GIP-Tirzepatide-Gs/β1/γ2
7DTY 7DTY-GIP-GIP-Gs/β1/γ2
Net Summary
Imin 2.71333
Number of Linked Nodes 946
Number of Links 1144
Number of Hubs 182
Number of Links mediated by Hubs 709
Number of Communities 19
Number of Nodes involved in Communities 256
Number of Links involved in Communities 385
Path Summary
Number Of Nodes in MetaPath 113
Number Of Links MetaPath 112
Number of Shortest Paths 2373326
Length Of Smallest Path 3
Average Path Length 28.256
Length of Longest Path 56
Minimum Path Strength 0.373333
Average Path Strength 5.92126
Maximum Path Strength 21.7867
Minimum Path Correlation 0.7
Average Path Correlation 0.989
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.94118
Average % Of Corr. Nodes 51.2033
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 54.6615
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following consensuses:
IdComponents
glucagon_on_gpglp_on_gp
gluc_on_gp
secretin_on_gp
gip_on_gp



You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download gip_on_gp.zip



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