Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
11x28 8.5954174
21x35 7.145426
31x36 3.245405
41x39 7.368528
51x42 5.13427
61x43 4.86254187
71x49 4.79407
81x50 5.7875409
91x57 9.3485127
102x38 5.1875476
112x39 5.11407
122x42 6.218577
132x45 7.275479
142x50 5.1125429
152x53 3.50333626
162x57 3.68528
172x63 7.015406
183x21 5.212527
193x30 5.072526
203x32 4.54426
213x34 5.76505
223x36 4.01527
233x38 6.405407
243x40 4.9725428
253x42 7.33286777
263x46 6.5275479
273x50 7.232579
283x51 8.06408
293x54 4.85408
30I2x55 6.094134
314x63 3.07404
32E2.P167 5.35521
33E2.K179 5.3025405
345x36 10.1175424
355x40 11.0125425
365x44 6.6375403
375x47 14.6375429
385x51 5.864216
395x53 2.2254206
405x58 7.468579
415x60 4.5925404
426x48 7.512529
436x49 4.81254216
446x51 5.558507
456x55 5.28286726
466x58 11.642524
476x62 10.5825424
487x35 7.405425
497x38 4.724526
507x39 6.72167624
517x43 4.7025425
527x53 5.9475479
537x54 8.28254126
548x54 4.84254126
55G.HN.43 4.17419
56G.HN.47 2.898515
57G.HN.52 5.62754134
58G.S1.02 5.704555
59G.S1.04 5.075457
60G.S1.06 6.66459
61G.H1.01 3.325459
62G.S2.05 5.445143
63G.S2.06 8.722558
64G.S2.08 7.472555
65G.S3.01 6.5975454
66G.S3.03 8.7725457
67G.S3.04 12.21254147
68G.S3.05 4.212557
69G.s3h2.03 5.32667639
70G.H2.06 6.2475439
71G.H2.07 5.75571739
72G.h2s4.01 8.895439
73G.S4.03 5.4025458
74G.S4.04 7.8525499
75G.s4h3.04 7.60754168
76G.s4h3.05 6.51254169
77G.H3.06 4.1075406
78G.H3.09 7.568599
79G.H3.13 4.5975496
80G.H3.17 7.43571765
81G.H3.18 9.6954249
82G.h3s5.03 4.874248
83G.S5.03 4.0775408
84G.S5.04 5.575699
85G.S5.05 3.926676159
86G.S5.06 4.846599
87G.HG.04 4.878508
88G.HG.13 4.9754166
89G.hgh4.01 4.1254105
90G.hgh4.02 4.655108
91G.hgh4.05 7.294297106
92G.H4.10 8.1925106
93G.H4.15 5.522598
94G.h4s6.02 5.352597
95G.h4s6.04 4.3525405
96G.h4s6.11 6.19497
97G.S6.01 4.59496
98G.S6.02 6.5185228
99G.H5.03 6.38254158
100G.H5.05 5.675455
101G.H5.08 6.05167658
102G.H5.11 4.79558
103G.H5.13 9.6254227
104G.H5.16 3.5025406
105G.H5.26 4.498507
106b.1x11 4.444268
107b.1x13 5.4875401
108b.1x14 2.05404
109b.lh12x2 5.4375408
110b.lhb1x9 4.5325403
111b.lhb1x11 3.166514
112b.l1x3 11.304519
113b.l1x7 7.065419
114b.b2x1 10.1525468
115b.b2x3 4.338516
116b.b2x5 6.48167617
117b.b3x1 4.0854115
118b.b3x2 4.59415
119b.b3x3 4.565118
120b.b3x4 6.285419
121b.b3x6 7.71419
122b.l3x2 5.8825419
123b.b4x2 7.635408
124b.b4x3 4.9645117
125b.b4x4 9.6975418
126b.b4x5 4.0445117
127b.b4x6 11.416519
128b.b5x3 7.67857719
129b.b5x4 3.65254115
130b.l5x1 4.59754118
131b.l5x5 8.668539
132b.b6x5 4.475606
133b.l7x2 5.314539
134b.b8x3 3.19833636
135b.l9x3 8.14333639
136b.l9x6 6.85625838
137b.l9x7 3.3075437
138b.b10x2 4.2375406
139b.b10x5 4.704539
140b.l10x1 4.7945283
141b.b11x1 5.3365285
142b.b11x2 4.56667637
143b.b11x3 4.245405
144b.b11x4 5.428539
145b.b11x6 6.346539
146b.l11x2 7.636539
147b.b12x3 3.6225488
148b.b12x6 8.82429738
149b.b13x7 8.436587
150b.l13x3 8.86571789
151b.l13x7 5.1225489
152b.b14x3 4.54405
153b.b15x1 7.7175489
154b.b15x2 9.48446
155b.b15x3 4.00833689
156b.l15x2 5.495689
157b.b16x2 4.4675485
158b.b16x4 10.2417686
159b.b16x5 4.86167645
160b.b16x6 9.04571788
161b.b16x7 6.9725449
162b.l16x3 8.5525443
163b.b17x3 6.0525485
164b.b17x4 6.978545
165b.b17x5 9.365447
166b.b17x7 9.356548
167b.l17x3 9.59333649
168b.l17x6 8.055439
169b.b18x3 3.63448
170b.l18x1 7.56625816
171b.l18x2 7.4475417
172b.l18x3 7.24415
173b.b19x2 8.192546
174b.b19x4 6.2225448
175b.l19x2 7.4675449
176b.b20x2 6.7175446
177b.b20x4 10.5467648
178b.b20x6 9.08833646
179b.b21x1 11.6625447
180b.b21x2 5.02546
181b.b21x5 5.27414
182b.b21x7 15.98405
183b.b22x1 4.875468
184b.b22x5 4.92286717
185b.l22x5 9.328519
186b.b23x6 7.33429767
187b.l23x1 8.7125466
188b.b24x3 4.048565
189b.l24x3 5.825405
190b.l25x3 11.756509
191b.l25x6 11.175468
192b.l25x7 4.97467
193b.l26x3 6.445417
194b.b27x1 3.825416
195b.b27x3 5.785468
196b.l27x1 8.81143769
197b.b28x4 12.0325466
198b.b28x6 10.836569
199b.b28x7 5.242519
200g.h1x1 6.91402
201g.l1x4 6.91448
202g.h2x11 9.4416
203g.ctx3 7.38167619
204g.ctx5 4.3125419
205g.ctx6 4.99667616
206g.ctx16 5.565618
207Lig 9.176431420
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
13x37 Lig 15.11310.92NoYes070
23x36 3x37 15.56825.99YesNo077
33x36 6x48 28.11563.73YesYes279
46x45 6x48 41.81767.5NoYes099
53x43 6x45 43.07653.65NoNo089
63x43 7x53 43.29633.52NoYes089
72x38 3x49 10.94875.39YesNo068
83x50 7x53 50.59457.2YesYes799
93x54 5x64 13.60932.82YesNo085
103x55 5x64 12.014.23NoNo075
113x50 G.H5.23 57.52792.79YesNo094
123x53 G.H5.23 57.93423.23NoNo084
133x53 G.H5.19 69.2834.2NoNo087
143x54 G.H5.16 15.08363.04YesYes086
15G.H5.15 G.H5.19 69.48954.25NoNo087
16G.S1.02 G.S3.01 10.47764.47YesYes554
17G.H5.11 G.H5.15 69.63633.07YesNo588
18G.H5.12 G.H5.16 16.57193.04NoYes066
19G.H5.11 G.S1.04 69.89134.47YesYes587
20G.S1.04 G.S3.05 40.36715.65YesYes577
21G.S1.06 G.S3.05 49.7954.24YesYes597
22G.H1.01 G.S1.06 95.23927.05YesYes599
23G.H1.01 G.s1h1.01 95.5761.74YesNo099
24G.S4.04 G.s1h1.01 95.80754.52YesNo099
25G.H3.08 G.S4.04 99.87756.09NoYes099
26G.H2.04 G.H3.08 99.91826.07NoNo099
27G.H2.04 G.H2.07 1003NoYes099
28G.H2.07 b.l7x2 30.21855.69YesYes399
29b.b6x1 b.l7x2 30.12092.83NoYes099
30G.H2.10 b.b6x1 59.87663.24NoNo079
31G.H2.09 G.H2.10 34.79854.42NoNo087
32G.H2.09 b.l27x1 24.28176.35NoYes689
33b.b26x1 b.l27x1 29.29394.94NoYes099
34b.b26x1 b.b26x2 29.0273.44NoNo097
35b.b26x2 b.b2x3 28.77836.48NoYes076
36G.S1.04 G.S4.03 40.57475.71YesYes578
37G.S1.06 G.S4.03 45.4898.56YesYes598
38G.H2.07 b.l9x6 69.96437.72YesYes398
39b.b6x1 b.l9x6 30.90933.59NoYes098
40G.H2.10 b.b2x1 24.97436.72NoYes078
41b.b2x1 b.l27x1 24.3058.68YesYes689
42b.l11x1 b.l9x6 24.099210.14NoYes398
43b.b11x6 b.l11x1 24.67963.71YesNo399
44b.b11x6 b.l9x3 13.726813.95YesYes399
45b.b11x4 b.l9x3 10.04876.85YesYes399
46b.b10x3 b.b11x4 16.21893.38NoYes389
47b.b10x3 b.b6x2 16.86718.45NoNo088
48b.b10x2 b.b6x2 16.74383.38YesNo068
49b.b10x2 b.b10x4 10.42486.96YesNo066
50b.b11x6 b.l9x7 10.23863YesYes397
51G.S4.04 G.S5.04 13.05083.65YesYes999
52G.H2.06 b.l9x6 21.0525.97YesYes398
53G.H2.06 b.l17x6 20.75189.68YesYes399
54G.H2.09 G.H3.17 10.40049.52NoYes685
55G.H3.17 b.l25x6 11.22775YesYes658
56b.l25x6 b.l27x1 19.519612YesYes689
57b.l17x5 b.l17x6 13.2535.89NoYes069
58b.l17x5 b.l19x2 13.1855.89NoYes069
59b.b20x4 b.b20x6 10.62584.28YesYes486
60b.l17x6 b.l19x1 11.590811.98YesNo099
61b.l19x1 b.l21x8 11.51063.35NoNo094
62b.l21x8 b.l23x1 11.43485.03NoYes046
63b.b22x1 b.l25x6 29.43783.88YesYes688
64b.b22x1 b.l25x7 31.7737.93YesYes687
65b.b24x3 b.l25x7 25.04883.42YesYes657
66b.b24x3 b.b25x7 22.97123.17YesNo057
67b.b25x7 b.lhb1x11 21.64134.24NoYes074
68b.lhb1x11 b.lhb1x9 10.06682.92YesYes043
69b.b2x3 b.b2x5 10.24135.82YesYes167
705x47 6x48 12.70834.29YesYes299
713x49 3x53 11.16868.3NoNo088
72G.S1.02 G.S1.04 10.84944.47YesYes557
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
2x633x217.910YesYes6721
3x213x254.182YesNo7912
3x21E2x508.362YesNo7911
3x21Lig3.022YesYes7010
3x25E2x507.282NoNo9921
3x293x303.232NoYes6611
3x293x335.092NoNo6511
3x29Lig7.462NoYes6010
3x304x573.232YesNo6612
3x304x602.962YesNo6511
3x304x617.612YesNo6412
3x30Lig8.332YesYes6010
3x337x383.522NoYes5612
3x33Lig26.942NoYes5010
3x363x375.992YesNo7721
3x375x4310.750NoNo7512
3x37Lig10.920NoYes7010
4x574x613.072NoNo6422
4x605x392.962NoNo5511
4x60Lig10.232NoYes5010
E2x50Lig3.942NoYes9010
6x62E2x5111.552YesNo4412
5x36E2.K1799.172YesYes4512
5x355x394.90NoNo5521
5x365x4016.582YesYes4511
5x36Lig11.982YesYes4010
5x39Lig3.72NoYes5010
5x406x556.032YesYes5611
5x406x5914.622YesNo5512
5x40Lig6.822YesYes5010
5x446x553.50YesYes3621
6x516x555.340YesYes7621
6x517x383.650YesYes7622
6x556x585.142YesYes6411
6x556x595.172YesNo6512
6x556x623.52YesYes6411
6x55Lig8.32YesYes6010
6x586x6212.42YesYes4411
6x587x316.192YesNo4412
6x587x3428.662YesNo4511
6x58Lig5.822YesYes4010
6x62Lig14.882YesYes4010
7x34Lig6.132NoYes5010
5x366x632.742YesNo4312
3x21E1.T892.592YesNo7412

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
100.00Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
92.86Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
75.00Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
75.00Single4PY02MeSATP4PY0-P2Y12-2MeSATP
63.16Single9J0IUDP-Glucuronic acid9J0I-P2Y14-UDP-Glucuronic acid-Gi1/β1/γ2
55.00Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
52.94Single4NTJAZD12834NTJ-P2Y12-AZD1283
52.38Single9J0FNADH9J0F-P2Y14-NADH-Gi1/β1/γ2
47.83Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
42.11Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
40.91Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
40.91Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
38.10Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
36.84Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
36.36Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
36.36Single9NS9TUG-13759NS9-FFA2-TUG-1375-Compound 187-Gi1/β1/γ2
36.36Single9V2NMacimorelin9V2N-Ghrelin-Macimorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
35.29Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
35.00Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
35.00Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
35.00Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
35.00Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
35.00Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
35.00Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
35.00Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
35.00Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
35.00Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
34.78Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
33.33Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
33.33Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
33.33Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
33.33Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
33.33Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
33.33Single9IXXLTD49IXX-CysLT2-LTD4-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
31.82Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
31.82Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
31.82Single8ZPLHF511168ZPL-CXCR4-HF51116
31.58Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
31.58Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
31.58Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
31.25Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
31.25Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
31.25Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
30.43Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
30.43Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
30.43Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
30.43Single9CM7TUG-13759CM7-FFA2-TUG-1375-AZ-1729-Gi1/β1/γ2
30.43Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
30.43Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
30.00Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
30.00Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
30.00Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
30.00Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
30.00Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
30.00Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
30.00Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
30.00Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
30.00Single8QOTNanobody-E8QOT-μ-Nanobody-E
30.00Consensusa3_on_gpOrthosteric Liganda3a_on_gp
30.00Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
30.00Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
30.00Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
30.00Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
30.00Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
29.63Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
29.63Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
29.17Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
29.17Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
29.17Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
29.17Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
29.17Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
29.17Single8WKYPG-9348WKY-MC4-PG-934
28.57Single5TZRMK86665TZR-FFA1-MK8666
28.57Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
28.57Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
28.57Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
28.57Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
28.57Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
28.57Single9UY3Anamorelin9UY3-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
28.00Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
28.00Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
28.00Single9IK8SST analogue9IK8-SST1-SST analogue-Gi1/β1/γ2
28.00Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
28.00Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
27.78Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
27.78Single8T3VDocosa-4,7,10,13,16,19-Hexaenoic acid8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
27.59Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
27.59Single9KDFRES-701-39KDF-ETB-RES-701-3
27.27Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
27.27Single4RWADIPP-NH24RWA-δ-DIPP-NH2
27.27Single5TZYMK8666; AP85TZY-FFA1-MK8666; AP8
27.27Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
27.27Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
27.27Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
27.27Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
27.27Single8Y6WTUG-13758Y6W-FFA2-TUG-1375-4-CMTB-Gi1/β1/γ2
27.27Single9CM3TUG-13759CM3-FFA2-TUG-1375-Compound 187-chim(NtGi1L-Gs-CtGq)/β1/γ2
27.27Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
27.27Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
26.92Single3OE0CVX153OE0-CXCR4-CVX15
26.92Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
26.92Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
26.92Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
26.92Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
26.92Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
26.92Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
26.67Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
26.32Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
26.32Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ2
26.32Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
26.32Single8K9LDamgo8K9L-μ-Damgo-BMS-986122-Gi3/β1/γ1
26.32Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
26.32Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Gi1/β1/γ2
26.09Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
26.09Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
26.09Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
26.09Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
26.09Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
26.09Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
26.09Single8T3OTUG-8918T3O-FFA4-TUG-891-chim(NtGi2L-Gs-CtGq)/β1/γ2
26.09Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
26.09Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
26.09Single9JH5C16:0 Ceramide9JH5-CysLT2-C16:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
26.09Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
26.09Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
25.93Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
25.93Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
25.93Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
25.00Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
25.00Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
25.00Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
25.00Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
25.00Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
25.00Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
25.00Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
25.00Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
25.00Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
25.00Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
25.00Single8QJ2pN1628QJ2-MC4-pN162-Gs
25.00Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
25.00Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
25.00Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
25.00Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
25.00Single9IYAONO-97105319IYA-GPR55-ONO-9710531
25.00Single9JH6C20:0 Ceramide9JH6-CysLT2-C20:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Consensusa3_onOrthosteric Liganda3a_on
25.00Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
25.00Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
25.00Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
25.00Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
25.00Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
25.00Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
24.14Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
24.14Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
24.00Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
24.00Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
24.00Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
24.00Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
24.00Single8IEBA1LYA8IEB-GPR156-A1LYA
24.00Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
24.00Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
23.81Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
23.81Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
23.81Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
23.81Single6Z4SSR486926Z4S-NTS1-SR48692
23.81Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
23.81Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
23.81Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
23.81Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
23.81Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
23.81Single9GE2ML1849GE2-GPR55-ML184-chim(NtGi1-G13)/β1/γ2
23.81Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
23.81Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
23.53Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
23.53Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
23.33Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
23.33Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
23.33Single8W8XBeta-MSH8W8X-MC3-β-MSH-Ca-Gs/β1/γ2
23.33Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
23.08Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
23.08Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
23.08Single8IEBA1LYA8IEB-GPR156-A1LYA
23.08Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
23.08Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
23.08Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
23.08Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
22.73Single6E59L-7607356E59-NK1-L-760735
22.73Single6J20Aprepitant6J20-NK1-Aprepitant
22.73Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
22.73Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
22.73Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
22.73Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
22.73Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
22.73Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
22.73Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.73Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
22.73Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
22.73Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
22.73Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
22.73Single8Y73Peptide8Y73-μ-Peptide-MPAM-15-Gi1/β1/γ2
22.73Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
22.73Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
22.73Single9CLWTUG-13759CLW-FFA2-TUG-1375-4-CMTB-chim(NtGi1L-Gs-CtGq)/β1/γ2
22.73Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
22.73Single9IK9SST analogue9IK9-SST1-SST analogue-Gi1/β1/γ2
22.73Single9JMCDS-3801b9JMC-Motilin-DS-3801b-chim(Gs-CtGq)/β1/γ2
22.73Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
22.73Consensuslpa_onOrthosteric Ligandlpa1_on
22.73Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
22.22Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
22.22Single6PT2KGCHM076PT2-δ-KGCHM07
22.22Single6W25SHU91196W25-MC4-SHU9119-Ca
22.22Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.22Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
22.22Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
22.22Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
22.22Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
22.22Single9M1OMorphine-Modulating Neuropeptide B9M1O-NPFF2-Morphine-Modulating Neuropeptide B-Gi1/β1/γ2
22.22Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
22.22Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
22.22Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
21.88Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
21.74Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
21.74Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
21.74Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
21.74Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
21.74Single7YITNalfurafine7YIT-κ-Nalfurafine
21.74Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
21.74Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
21.74Single8XWACXCL18XWA-CXCR2-CXCL1
21.74Single8XWMCXCL68XWM-CXCR2-CXCL6
21.74Single8XWSCXCL58XWS-CXCR2-CXCL5
21.74Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
21.74Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
21.74Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
21.74Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
21.74Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
21.74Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
21.43Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
21.43Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
21.43Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
21.43Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
21.43Single8ZBISomatostatin-148ZBI-SST3-Somatostatin-14-Gi1/β1/γ2
21.43Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
21.43Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
21.43Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
21.43Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
21.43Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
21.21Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
21.21Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
21.05Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
21.05Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
21.05Single7F8YDevazepide7F8Y-CCKA-Devazepide
21.05Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
21.05Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
21.05Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
21.05Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
21.05Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.05Single8YYWAlpha-ketoglutarate8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
21.05Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
21.05Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
20.83Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
20.83Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
20.83Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
20.83Single7UM4AS26747237UM4-5-HT5A-AS2674723
20.83Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
20.83Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
20.83Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
20.83Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
20.83Single8JPFNeurotensin8JPF-NTS1-Neurotensin-SBI-553
20.83Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
20.83Single8XVUCXCL28XVU-CXCR2-CXCL2
20.83Single8XWFCXCL38XWF-CXCR2-CXCL3
20.83Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
20.83Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
20.83Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
20.83Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
20.83Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
20.83Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
20.83Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
20.83Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
20.83Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
20.69Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
20.69Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
20.69Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
20.69Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
20.69Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
20.69Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
20.69Single8ZRTET-18ZRT-ETB-ET-1
20.69Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
20.69Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
20.69Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
20.59Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
20.00Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
20.00Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
20.00Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
20.00Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
20.00Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
20.00Single6PT3DPI-2876PT3-δ-DPI-287
20.00Single6ZINSR486926ZIN-NTS1-SR48692
20.00Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
20.00Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
20.00Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
20.00Single7VV6C48/807VV6-MRGPRX2-C48/80
20.00Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
20.00Single7XN9L-054,5227XN9-SST2-L-054,522
20.00Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
20.00Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
20.00Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
20.00Single8IYXYL-3658IYX-GPR34-YL-365
20.00Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
20.00Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
20.00Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
20.00Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
20.00Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
20.00Single8ZPNAMD31008ZPN-CXCR4-AMD3100
20.00Single9JF4PD1683689JF4-BB1-PD168368
20.00Single9M2FNeuropeptide FF9M2F-NPFF1-Neuropeptide FF-Gi1/β1/γ2
20.00Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
20.00Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
20.00Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
20.00Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
20.00Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
19.35Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
19.35Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
19.35Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
19.35Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
19.35Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
19.35Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
19.35Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
19.23Single4IARErgotamine4IAR-5-HT1B-Ergotamine
19.23Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
19.23Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
19.23Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
19.23Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
19.23Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
19.23Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
19.23Single8IEIA1LYA8IEI-GPR156-A1LYA
19.23Single8IEPA1LYA8IEP-GPR156-A1LYA
19.23Single8IEPA1LYA8IEP-GPR156-A1LYA
19.23Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
19.23Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
19.23Single8KIGSHU91198KIG-MC3-SHU9119-Ca
19.23Single8XWNCXCL88XWN-CXCR2-CXCL8
19.23Single9HB3Mambaquaretin-19HB3-V2-Mambaquaretin-1
19.23Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
19.23Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
19.23Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
19.23Consensuslpl_onOrthosteric Ligands1p_on lpa_on
19.23Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
19.23Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
19.23Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
19.23Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
19.23Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
19.23Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
19.23Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
19.05Single4EJ4Naltrindole4EJ4-δ-Naltrindole
19.05Single4QIMANTA XV4QIM-SMO-ANTA XV
19.05Single5UIGCmpd-15UIG-A2A-Cmpd-1
19.05Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
19.05Single6DRXLisuride6DRX-5-HT2B-Lisuride
19.05Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
19.05Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
19.05Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
19.05Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
19.05Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
19.05Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
19.05Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
19.05Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
19.05Single8ZYYNeurotensin peptide 8-138ZYY-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
19.05Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
19.05Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
19.05Consensuscck_offOrthosteric Ligandccka_off
19.05Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
19.05Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
18.75Single6IGLIRL16206IGL-ETB-IRL1620
18.75Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
18.75Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
18.75Single8IY6Endothelin-18IY6-ETB-Endothelin-1
18.75Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
18.75Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
18.75Consensusbradykinin_onOrthosteric Ligandbk2_on
18.75Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
18.75Consensusendothelin_onOrthosteric Ligandetb_on eta_on
18.75Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
18.75Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
18.52Single3QAKUK-4320973QAK-A2A-UK-432097
18.52Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
18.52Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
18.52Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
18.52Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
18.52Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
18.52Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
18.52Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
18.52Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
18.52Single9E82SDF-1-beta9E82-ACKR3-SDF-1-β-Arrestin2
18.52Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
18.52Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
18.52Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
18.18Single5GLHEndothelin-15GLH-ETB-Endothelin-1
18.18Single5N2SPSB365N2S-A1-PSB36
18.18Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
18.18Single5XPRBosentan5XPR-ETB-Bosentan
18.18Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
18.18Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
18.18Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
18.18Single7LD3Adenosine7LD3-A1-Adenosine-MIPS521-Gi2/β1/γ2
18.18Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
18.18Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
18.18Single7W41PD1762527W41-BB2-PD176252
18.18Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.18Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
18.18Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
18.18Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
18.18Single8GNEKW-63568GNE-A2A-KW-6356-Na
18.18Single8S4DCMF-0198S4D-Apelin-CMF-019
18.18Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
18.18Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
18.18Single8WGBVU01550418WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
18.18Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
18.18Single9ARYSerotonin9ARY-5-HT2A-Serotonin-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
18.18Single9HAPTolvaptan9HAP-V2-Tolvaptan
18.18Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
18.18Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
18.18Consensusbombesin_offOrthosteric Ligandbb2_off
18.18Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
18.18Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
18.18Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
18.18Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
18.18Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
17.86Single5WF5UK-4320975WF5-A2A-UK-432097
17.86Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
17.86Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
17.86Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
17.86Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
17.86Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
17.86Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
17.86Single8W8YGamma-MSH8W8Y-MC3-γ-MSH-Ca-Gs/β1/γ2
17.86Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
17.86Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
17.86Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
17.86Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
17.86Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
17.86Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
17.86Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
17.86Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
17.86Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
17.86Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
17.86Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
17.65Single3RFMCaffeine3RFM-A2A-Caffeine
17.65Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
17.65Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
17.65Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
17.65Consensusp2y_offOrthosteric Ligandp2y1_off
17.39Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
17.39Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
17.39Single4BV0Neurotensin4BV0-NTS1-Neurotensin
17.39Single4DJHJDTic4DJH-κ-JDTic
17.39Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
17.39Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
17.39Single5XR8AM8415XR8-CB1-AM841
17.39Single5XRAAM115425XRA-CB1-AM11542
17.39Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
17.39Single6J21Aprepitant6J21-NK1-Aprepitant
17.39Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
17.39Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
17.39Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
17.39Single7FEECP559407FEE-CB1-CP55940-ZCZ011
17.39Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
17.39Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
17.39Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
17.39Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
17.39Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
17.39Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
17.39Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
17.39Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
17.39Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
17.39Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
17.39Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
17.39Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
17.39Single8E0GBU728E0G-μ-BU72
17.39Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
17.39Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
17.39Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
17.39Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
17.39Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
17.39Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
17.39Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
17.39Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
17.39Single8ZWFJR14a8ZWF-C3aB-JR14a
17.39Single9BJKNaloxone9BJK-μ-Naloxone-NAM
17.39Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
17.39Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
17.39Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
17.39Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Consensusneurotensin_onOrthosteric Ligandnts1_on
17.39Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
17.39Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
17.39Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
17.39Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
17.39Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
17.39Consensustachykinin_offOrthosteric Ligandnk1_off
17.24Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
17.24Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
17.24Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
17.24Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
17.24Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
17.24Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
17.24Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
17.24Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
17.24Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
17.14Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
16.67Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
16.67Single3D4STimolol3D4S-β2-Timolol
16.67Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
16.67Single4XEENeurotensin4XEE-NTS1-Neurotensin
16.67Single4XESNeurotensin4XES-NTS1-Neurotensin
16.67Single4XNWMRS25004XNW-P2Y1-MRS2500
16.67Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
16.67Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
16.67Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
16.67Single6KQICP559406KQI-CB1-CP55940-Org27569
16.67Single6MXTSalmeterol6MXT-β2-Salmeterol
16.67Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
16.67Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
16.67Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
16.67Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
16.67Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
16.67Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
16.67Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
16.67Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
16.67Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
16.67Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/β1/γ2
16.67Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
16.67Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
16.67Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
16.67Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
16.67Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
16.67Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
16.67Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
16.67Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
16.67Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
16.67Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
16.67Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
16.67Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
16.67Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
16.67Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
16.67Single8XQJJN2418XQJ-Apelin-JN241
16.67Single9EBIPiclidenoson9EBI-A3A-Piclidenoson-chim(NtGi1L-Gs-CtGi1)/β1/γ2
16.67Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
16.67Single9JHJC18:0 Ceramide9JHJ-FPR2-ALX-C18:0 Ceramide-Gi1/β1/γ2
16.67Single9M4QDoxazosin9M4Q-Alpha1A-Doxazosin
16.67Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
16.67Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
16.67Consensus5ht2_onOrthosteric Ligand5ht2b_on
16.67Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
16.67Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
16.67Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
16.67Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
16.67Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
16.67Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
16.67Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
16.67Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
16.67Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
16.67Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
16.67Consensuslpa_offOrthosteric Ligandlpa1_off
16.67Consensuslpl_offOrthosteric Ligands1p_off lpa_off
16.67Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
16.67Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
16.67Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
16.67Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
16.67Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
16.67Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
16.67Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
16.67Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
16.13Single7SK3CXCL127SK3-ACKR3-CXCL12
16.13Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
16.13Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
16.13Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
16.13Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
16.13Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
16.00Single4BUONeurotensin4BUO-NTS1-Neurotensin
16.00Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
16.00Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
16.00Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
16.00Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
16.00Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
16.00Single7EZCUKA7EZC-A2A-UKA
16.00Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
16.00Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
16.00Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
16.00Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
16.00Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
16.00Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
16.00Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
16.00Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.00Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
16.00Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
16.00Single8S2TIsoprenaline8S2T-β1-Isoprenaline-chim(NtGi1-Gs)/β1/γ2
16.00Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
16.00Single9CGJC6-Quino9CGJ-δ-C6-Quino-Gi1/β1/γ2
16.00Single9M54Neuropeptide VF9M54-NPFF2-Neuropeptide VF-Gi1/β1/γ2
16.00Consensuscck_onOrthosteric Ligandccka_on cckb_on
16.00Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
16.00Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
16.00Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
16.00Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
15.79Single6HLLCP999946HLL-NK1-CP99994
15.79Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
15.79Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
15.79Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
15.79Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
15.79Single7SRQLSD7SRQ-5-HT2B-LSD
15.79Single7UL2SR486927UL2-NTS1-SR48692-Na
15.79Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
15.79Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
15.79Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
15.79Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
15.79Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
15.79Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
15.79Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
15.79Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
15.79Consensusneurotensin_offOrthosteric Ligandnts1_off
15.79Consensusnts1_offOrthosteric Ligand7UL2-NTS1-SR48692-Na
15.62Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
15.62Single8W8WAlpha-MSH8W8W-MC3-α-MSH-Ca-Gs/β1/γ2
15.62Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
15.62Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
15.62Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
15.62Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
15.38Single3NY9ICI118-5513NY9-β2-ICI118-551
15.38Single5ZTYAM102575ZTY-CB2-AM10257
15.38Single6KNMJN241-96KNM-Apelin-JN241-9
15.38Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
15.38Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
15.38Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
15.38Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
15.38Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
15.38Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
15.38Single8XQJJN2418XQJ-Apelin-JN241
15.38Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
15.38Single8Y72Peptide8Y72-μ-Peptide-BMS-986122-Gi1/β1/γ2
15.38Single9CGKC5-Quino9CGK-δ-C5-Quino-Gi1/β1/γ2
15.38Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
15.38Single9IPVJR14a9IPV-C3aB-JR14a-Gi1/β1/γ2
15.38Single9M0RNeuropeptide VF9M0R-NPFF1-Neuropeptide VF-Gi1/β1/γ2
15.38Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
15.38Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
15.38Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
15.38Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
15.38Consensuskisspeptin_onOrthosteric Ligandkiss1_on
15.38Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Consensuspth2_on_gpOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
15.38Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
15.38Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
15.38Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
15.38Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
15.15Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
15.15Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
15.00Single3PWHZM-2413853PWH-A2A-ZM-241385
15.00Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
15.00Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
15.00Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
15.00Single6B73MP11046B73-κ-MP1104
15.00Single6DS0Ly2660976DS0-5-HT2B-Ly266097
15.00Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
15.00Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
15.00Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
15.00Single6ME9Ramelteon6ME9-MT2-Ramelteon
15.00Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
15.00Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
15.00Single7BR3Elagolix7BR3-GnRH1-Elagolix
15.00Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
15.00Single7F8ULintitript7F8U-CCKA-Lintitript
15.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
15.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
15.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
15.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
15.00Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.00Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
15.00Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
15.00Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
15.00Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
15.00Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
15.00Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
15.00Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
15.00Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
15.00Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
15.00Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
15.00Single8U4PAMD31008U4P-CXCR4-AMD3100-Gi1/β1/γ2
15.00Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
15.00Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
15.00Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
15.00Single9EBHAdenosine9EBH-A3A-Adenosine-Gi1/β1/γ2
15.00Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
15.00Single9KPESA09KPE-TAS2R16-SA0-Gi1/β1/γ2
15.00Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
15.00Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.00Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
15.00Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
14.81Single4XT1Fractalkine4XT1-US28-Fractalkine
14.81Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
14.81Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
14.81Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
14.81Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
14.81Single8IEIA1LYA8IEI-GPR156-A1LYA
14.81Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
14.81Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
14.81Single8ZBJSomatostatin-148ZBJ-SST5-Somatostatin-14-Gi1/β1/γ2
14.81Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
14.81Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
14.81Single9BUYLM1899BUY-β2-LM189-Gi1/β1/γ2
14.81Single9M4TSilodosin9M4T-Alpha1A-Silodosin
14.81Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
14.81Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
14.81Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
14.81Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
14.81Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
14.71Single6IGKEndothelin-36IGK-ETB-Endothelin-3
14.71Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
14.71Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
14.29Single3REYXAC3REY-A2A-XAC
14.29Single3RZECidoxepin3RZE-H1-Cidoxepin
14.29Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
14.29Single4MBSMaraviroc4MBS-CCR5-Maraviroc
14.29Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
14.29Single5IU7Q274563465IU7-A2A-Q27456346-Na
14.29Single5IUBQ274563445IUB-A2A-Q27456344-Na
14.29Single5JTBZM-2413855JTB-A2A-ZM-241385
14.29Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
14.29Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
14.29Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
14.29Single5UVIZM-2413855UVI-A2A-ZM-241385
14.29Single6AQFZM-2413856AQF-A2A-ZM-241385
14.29Single6HLOAprepitant6HLO-NK1-Aprepitant
14.29Single6IQLL7458706IQL-D4-L745870
14.29Single6MH8ZM-2413856MH8-A2A-ZM-241385
14.29Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
14.29Single6TPKRetosiban6TPK-OT-Retosiban
14.29Single6TPNHTL66416TPN-OX2-HTL6641
14.29Single6VI4JDTic6VI4-κ-JDTic
14.29Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
14.29Single7AROLUF58337ARO-A2A-LUF5833-Na
14.29Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
14.29Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
14.29Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
14.29Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
14.29Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
14.29Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
14.29Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
14.29Single7SK5CXCL127SK5-ACKR3-CXCL12
14.29Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
14.29Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
14.29Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
14.29Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
14.29Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
14.29Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
14.29Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
14.29Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
14.29Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.29Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
14.29Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
14.29Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
14.29Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
14.29Single9ARXSerotonin9ARX-5-HT2A-Serotonin
14.29Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
14.29Single9JH3CMF-0199JH3-Apelin-CMF-019-Gi1/β1/γ2
14.29Single9JMDAzithromycin9JMD-Motilin-Azithromycin-chim(Gs-CtGq)/β1/γ2
14.29Single9KFIRelaxin-39KFI-RXFP3-Relaxin-3-Gi2/β1/γ2
14.29Single9KPDSA09KPD-TAS2R16-SA0-chim(Gs-CtGt3)/β1/γ2
14.29Single9LRDHistamine9LRD-H1-Histamine-Gi1/β1/γ2
14.29Consensusa2_offOrthosteric Liganda2a_off
14.29Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
14.29Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
14.29Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
14.29Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
14.29Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
14.29Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
14.29Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
14.29Consensusgrh_offOrthosteric Ligandgnrh1_off
14.29Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
14.29Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
14.29Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
14.29Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
14.29Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
14.29Consensusvasop-oxy_offOrthosteric Ligandot_off
13.89Consensuscrf1_on_gpOrthosteric Ligand6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF1-Corticoliberin-Gs/β1/γ2
13.79Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.79Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
13.79Consensusangiotensin_onOrthosteric Ligandat1_on
13.79Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
13.79Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
13.79Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
13.79Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
13.79Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
13.79Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
13.64Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
13.64Single3EMLZM-2413853EML-A2A-ZM-241385
13.64Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
13.64Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
13.64Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
13.64Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
13.64Single5DHGC-355DHG-NOP-C-35
13.64Single5DHHSB-6121115DHH-NOP-SB-612111
13.64Single5IU8Q274563475IU8-A2A-Q27456347-Na
13.64Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
13.64Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
13.64Single5UENDU1725UEN-A1-DU172
13.64Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
13.64Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
13.64Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
13.64Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
13.64Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
13.64Single6PS1Timolol6PS1-β2-Timolol
13.64Single6S0LZM-2413856S0L-A2A-ZM-241385
13.64Single6XBM5LWE6XBM-SMO-5LWE-Gi1/β1/γ2
13.64Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
13.64Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
13.64Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
13.64Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
13.64Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
13.64Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
13.64Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
13.64Single7PYRPSB-21157PYR-A2A-PSB-2115
13.64Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
13.64Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
13.64Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
13.64Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
13.64Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
13.64Single7V3ZCP559407V3Z-CB1-CP55940
13.64Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
13.64Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
13.64Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
13.64Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
13.64Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
13.64Single8CU6LJ-45178CU6-A2A-LJ-4517
13.64Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
13.64Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
13.64Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
13.64Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
13.64Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
13.64Single8TH3AT118-H Nanobody8TH3-AT1-AT118-H Nanobody
13.64Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.64Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.64Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.64Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
13.64Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
13.64Single9H37A1IR09H37-A2A-A1IR0-Na
13.64Single9PQD(6m)-1-methyl-6-(1,2,5,6-tetrahydropyridin-3-yl)-1h-indole9PQD-α2a-(6m)-1-methyl-6-(1,2,5,6-tetrahydropyridin-3-yl)-1h-indole
13.64Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
13.64Consensus5ht5_onOrthosteric Ligand5ht5a_on
13.64Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
13.64Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
13.64Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
13.64Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
13.64Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
13.64Consensusalpha2_onOrthosteric Ligandalpha2b_on
13.64Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
13.64Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
13.64Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
13.64Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
13.64Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
13.64Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
13.64Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
13.64Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
13.51Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
13.51Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
13.33Single6JODAngiotensin II6JOD-AT2-Angiotensin II
13.33Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
13.33Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
13.33Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
13.33Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
13.33Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
13.33Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
13.33Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
13.33Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
13.33Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
13.33Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
13.33Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
13.33Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
13.33Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
13.33Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
13.33Consensusvasop-oxy_onOrthosteric Ligandv2_on
13.33Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
13.04Single2YCWS-Carazolol2YCW-β1-S-Carazolol
13.04Single5C1MBU725C1M-μ-BU72
13.04Single5D6LS-Carazolol5D6L-β2-S-Carazolol
13.04Single5IUAQ274563485IUA-A2A-Q27456348-Na
13.04Single5N2RPSB-365N2R-A2A-PSB-36-Na
13.04Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
13.04Single5TVNLSD5TVN-5-HT2B-LSD
13.04Single5X7DS-Carazolol5X7D-β2-S-Carazolol-Cmpd-15
13.04Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
13.04Single6HLPNetupitant6HLP-NK1-Netupitant
13.04Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
13.04Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
13.04Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
13.04Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
13.04Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
13.04Single6PS6Timolol6PS6-β2-Timolol
13.04Single6S0QZM-2413856S0Q-A2A-ZM-241385
13.04Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
13.04Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
13.04Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
13.04Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
13.04Single7C61Ergotamine7C61-5-HT1B-Ergotamine
13.04Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
13.04Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
13.04Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
13.04Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
13.04Single7SINNPS-21437SIN-CaS-NPS-2143
13.04Single7SINNPS-21437SIN-CaS-NPS-2143
13.04Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
13.04Single7WC6LSD7WC6-5-HT2A-LSD
13.04Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
13.04Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
13.04Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
13.04Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
13.04Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
13.04Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
13.04Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
13.04Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.04Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.04Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.04Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
13.04Single8JXSPF-61428JXS-D1-PF-6142
13.04Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
13.04Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
13.04Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.04Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.04Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
13.04Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
13.04Single8ZYTNeurotensin peptide 8-138ZYT-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
13.04Single9ARZ2-bromo-LSD9ARZ-5-HT2A-2-bromo-LSD
13.04Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
13.04Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
13.04Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
13.04Single9EE8Adenosine9EE8-A2A-Adenosine-Gs/β1/γ2
13.04Single9EHSLUF76029EHS-A3A-LUF7602
13.04Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
13.04Single9I52A1IZU9I52-D1-A1IZU-Gs/β1/γ2
13.04Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
13.04Single9KPFSA09KPF-TAS2R16-SA0-Gi1/β1/γ2
13.04Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
13.04Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
13.04Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
13.04Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
13.04Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
13.04Consensusadenosine_offOrthosteric Liganda1_off a2_off
13.04Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
13.04Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
13.04Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
13.04Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
13.04Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
13.04Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
13.04Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
13.04Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
12.90Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
12.90Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.90Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
12.90Single9JFYhNPSF9JFY-NPFF2-hNPSF-Gi1/β1/γ2
12.90Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
12.90Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
12.90Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
12.90Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
12.50Single3P0GBI1671073P0G-β2-BI167107
12.50Single4XT3Fractalkine4XT3-US28-Fractalkine
12.50Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
12.50Single5D5AS-Carazolol5D5A-β2-S-Carazolol
12.50Single5D5BS-Carazolol5D5B-β2-S-Carazolol
12.50Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
12.50Single5V54Methiothepin5V54-5-HT1B-Methiothepin
12.50Single5V56TC1145V56-SMO-TC114
12.50Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
12.50Single6H7JIsoprenaline6H7J-β1-Isoprenaline
12.50Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
12.50Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
12.50Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
12.50Single6OS1TRV0266OS1-AT1-TRV026
12.50Single6TQ7SB-3348676TQ7-OX1-SB-334867
12.50Single7B6WCyclazosin7B6W-α1b-Cyclazosin
12.50Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
12.50Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
12.50Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
12.50Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
12.50Single7PX4PSB-21137PX4-A2A-PSB-2113
12.50Single7R0CAVP7R0C-V2-AVP-Arrestin2
12.50Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
12.50Single7TUYGSK682753A7TUY-GPR183-GSK682753A
12.50Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
12.50Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
12.50Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
12.50Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
12.50Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
12.50Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
12.50Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
12.50Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
12.50Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
12.50Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
12.50Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
12.50Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
12.50Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
12.50Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
12.50Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
12.50Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
12.50Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
12.50Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
12.50Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
12.50Single8XVLZibotentan8XVL-ETA-Zibotentan
12.50Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
12.50Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
12.50Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
12.50Single9EGOYVF9EGO-CB1-YVF-Gi1/β1/γ2
12.50Single9I54A1IZV9I54-D1-A1IZV-Gs/β1/γ2
12.50Single9KFKRelaxin-39KFK-RXFP4-Relaxin-3-Gi2/β1/γ2
12.50Consensus5ht1_offOrthosteric Ligand5ht1b_off
12.50Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
12.50Consensusa2_onOrthosteric Liganda2b_on
12.50Consensusa2_on_gpOrthosteric Liganda2b_on_gp
12.50Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
12.50Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
12.50Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
12.50Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
12.50Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
12.50Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
12.50Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
12.50Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
12.50Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
12.50Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
12.50Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
12.50Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
12.50Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
12.50Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
12.50Consensusrelaxin_onOrthosteric Ligandrxfp4_on
12.50Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
12.12Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
12.12Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
12.00Single4LDEBI1671074LDE-β2-BI167107
12.00Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
12.00Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
12.00Single6YVRNTS8-136YVR-NTS1-NTS8-13
12.00Single6ZG4HTL00099366ZG4-M1-HTL0009936
12.00Single7DFPSpiperone7DFP-D2-Spiperone
12.00Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
12.00Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
12.00Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
12.00Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
12.00Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
12.00Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
12.00Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.00Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
12.00Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
12.00Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.00Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
12.00Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
12.00Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
12.00Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
12.00Single8JD3JNJ-404118138JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
12.00Single8JJ8Formoterol8JJ8-β2-Formoterol
12.00Single8JJLOlodaterol8JJL-β2-Olodaterol
12.00Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
12.00Single8JWY2-1188JWY-A2A-2-118
12.00Single8JWZAB9288JWZ-A2A-AB928-Na
12.00Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
12.00Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
12.00Single9DGIZ85267113509DGI-CB1-Z8526711350
12.00Single9GL2Befiradol9GL2-5-HT1A-Befiradol-Gs/β1/γ2
12.00Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
12.00Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
12.00Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
12.00Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
12.00Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
12.00Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
12.00Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
12.00Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
12.00Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
12.00Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
12.00Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
12.00Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
12.00Consensusorexin_onOrthosteric Ligandox2_on
11.76Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
11.54Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
11.54Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
11.54Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
11.54Single5X93K-87945X93-ETB-K-8794
11.54Single6K1QIRL25006K1Q-ETB-IRL2500
11.54Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
11.54Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
11.54Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
11.54Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
11.54Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-SBI-553-chim(NtGi1-Go)/β1/γ2
11.54Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
11.54Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
11.54Single8XVJMacitentan8XVJ-ETA-Macitentan
11.54Single8ZWGJR14a8ZWG-C3aB-JR14a-Gi1/β1/γ2
11.54Single9AS02-bromo-LSD9AS0-5-HT2A-2-bromo-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
11.54Single9DYEBuspirone9DYE-5-HT1A-Buspirone-Go/β1/γ2
11.54Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
11.54Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
11.54Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
11.54Consensusendothelin_offOrthosteric Ligandetb_off
11.54Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
11.54Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.54Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.54Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
11.43Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
11.43Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
11.43Consensusbombesin_onOrthosteric Ligandbb2_on
11.43Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
11.43Consensuscrf1_onOrthosteric Ligand6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF1-Corticoliberin-Gs/β1/γ2
11.43Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
11.11Single2HPYAll-trans-Retinal2HPY-Rhodopsin-All-trans-Retinal
11.11Single4UG2CGS216804UG2-A2A-CGS21680
11.11Single5WF6UK-4320975WF6-A2A-UK-432097
11.11Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
11.11Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
11.11Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
11.11Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
11.11Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
11.11Single7Y14Beta-Alanine7Y14-MRGPRD-β-Alanine
11.11Single8A2OTheophylline8A2O-A2A-Theophylline-Na
11.11Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
11.11Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
11.11Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
11.11Single9IPYJR14a9IPY-C3aB-JR14a
11.11Single9IZASCH9002719IZA-HCA2-SCH900271-Gi1/β1/γ2
11.11Single9MD1Buspirone9MD1-5-HT1A-Buspirone-Gz/β1/γ2
11.11Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
11.11Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
11.11Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
10.71Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
10.71Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
10.71Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
10.71Single7F8XNN90567F8X-CCKA-NN9056
10.71Single7QA8Peptide7QA8-STE2-Peptide
10.71Single7QA8Peptide7QA8-STE2-Peptide
10.71Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
10.71Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
10.71Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
10.71Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
10.71Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
10.71Single8PKMBefiradol8PKM-5-HT1A-Befiradol-Gi1/β1/γ1
10.71Single8U4OCXCL128U4O-CXCR4-CXCL12-Gi1/β1/γ2
10.71Single8WDTphotoNECA8WDT-A2A-photoNECA
10.71Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
10.71Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
10.71Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
10.71Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
10.71Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
10.71Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
10.71Consensussomatostatin_offOrthosteric Ligandsst2_off
10.71Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
10.53Single3UZAGTPL92363UZA-A2A-GTPL9236
10.53Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
10.53Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
10.53Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
10.53Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
10.53Single7WC5Psilocin7WC5-5-HT2A-Psilocin
10.53Single7Y12Beta-Alanine7Y12-MRGPRD-β-Alanine-Gi1/β1/γ2
10.53Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.53Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.53Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
10.53Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
10.53Single8JPSCCL78JPS-ACKR1-CCL7
10.53Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
10.53Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
10.53Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
10.34Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
10.34Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
10.34Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
10.34Single7XNACYN1548067XNA-SST2-CYN154806
10.34Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
10.34Single9IQRMuscarinic toxin 39IQR-α2a-Muscarinic toxin 3
10.34Single9IQSMuscarinic toxin 39IQS-M4-Muscarinic toxin 3
10.34Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
10.00Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
10.00Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
10.00Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
10.00Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
10.00Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
10.00Single3PBLEticlopride3PBL-D3-Eticlopride
10.00Single4O9RCyclopamine4O9R-SMO-Cyclopamine
10.00Single5L7IVismodegib5L7I-SMO-Vismodegib
10.00Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
10.00Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
10.00Single6TP4ACT-4622066TP4-OX1-ACT-462206
10.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
10.00Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
10.00Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
10.00Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
10.00Single7V68Iperoxo7V68-M4-Iperoxo-LY2119620-Gi1/β1/γ2
10.00Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
10.00Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Single7XP6Strychnine7XP6-TAS2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
10.00Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
10.00Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
10.00Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
10.00Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
10.00Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
10.00Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
10.00Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
10.00Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
10.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.00Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
10.00Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
10.00Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
10.00Single8YN2Histamine8YN2-H1-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
10.00Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
10.00Single8ZYUNeurotensin peptide 8-138ZYU-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
10.00Single9AS7Psilocin9AS7-5-HT2A-Psilocin
10.00Single9IXJHistamine9IXJ-H2-Histamine-Gs/β1/γ2
10.00Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
10.00Single9U4WGonadoliberin-19U4W-GnRH1-Gonadoliberin-1-chim(NtGi1L-Gs-CtGq)/β1/γ2
10.00Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
10.00Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
10.00Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg4_on
10.00Consensusadgrg_on_gpOrthosteric Ligandadgrg2_on_gp adgrg4_on_gp
10.00Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
10.00Consensusgq_nucleotideOrthosteric Ligandgq_p2y
10.00Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
10.00Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
10.00Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
9.76Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
9.68Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
9.68Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
9.68Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
9.68Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
9.68Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
9.68Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
9.68Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
9.52Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
9.52Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
9.52Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
9.52Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
9.52Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
9.52Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
9.52Single3ODUIT1t3ODU-CXCR4-IT1t
9.52Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
9.52Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
9.52Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
9.52Single4QINSAG1.54QIN-SMO-SAG1.5
9.52Single4S0VSuvorexant4S0V-OX2-Suvorexant
9.52Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
9.52Single5WS3EMPA5WS3-OX2-EMPA
9.52Single5ZKQABT-4915ZKQ-PAF-ABT-491
9.52Single6AKXA4R6AKX-CCR5-A4R
9.52Single6AKYMaraviroc6AKY-CCR5-Maraviroc
9.52Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
9.52Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
9.52Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
9.52Single6TODEMPA6TOD-OX1-EMPA-Na
9.52Single6TPJSuvorexant6TPJ-OX2-Suvorexant
9.52Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
9.52Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
9.52Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
9.52Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
9.52Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
9.52Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.52Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
9.52Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
9.52Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
9.52Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
9.52Single7XRRLemborexant7XRR-OX2-Lemborexant
9.52Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
9.52Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
9.52Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
9.52Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
9.52Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
9.52Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.52Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.52Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
9.52Single8GNGIstradefylline8GNG-A2A-Istradefylline
9.52Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
9.52Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
9.52Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
9.52Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
9.52Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
9.52Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
9.52Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
9.52Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
9.52Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
9.52Single9EEAAdenosine9EEA-A2A-Adenosine-Gs/β1/γ2
9.52Single9H2XA1IR19H2X-A2A-A1IR1-Na
9.52Single9K6LSA09K6L-TAS2R16-SA0-Gi2/β1/γ2
9.52Single9LRBHistamine9LRB-H1-Histamine-Gs/β1/γ2
9.52Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
9.52Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
9.52Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
9.52Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
9.52Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
9.52Consensusalpha2_offOrthosteric Ligandalpha2c_off
9.52Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
9.52Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
9.52Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
9.52Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
9.52Consensusorexin_offOrthosteric Ligandox2_off ox1_off
9.52Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
9.52Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
9.52Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
9.52Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
9.52Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
9.52Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
9.52Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
9.52Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
9.52Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
9.52Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
9.38Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
9.38Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
9.38Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
9.38Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
9.38Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
9.38Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
9.09Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
9.09Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
9.09Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
9.09Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
9.09Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
9.09Single4ZJCSB-6740424ZJC-OX1-SB-674042
9.09Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
9.09Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
9.09Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
9.09Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
9.09Single6PS0S-Carazolol6PS0-β2-S-Carazolol
9.09Single6PS4ICI118-5516PS4-β2-ICI118-551
9.09Single6PS5S-Propranolol6PS5-β2-S-Propranolol
9.09Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
9.09Single6TP3Nemorexant6TP3-OX1-Nemorexant
9.09Single6TPGEMPA6TPG-OX2-EMPA
9.09Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
9.09Single6V9SGTPL114036V9S-OX1-GTPL11403
9.09Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
9.09Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
9.09Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
9.09Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
9.09Single6ZG9GSK10347026ZG9-M1-GSK1034702
9.09Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
9.09Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
9.09Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
9.09Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
9.09Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
9.09Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
9.09Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
9.09Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
9.09Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
9.09Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.09Single7T32ZM-2413857T32-A2A-ZM-241385
9.09Single7T94LY21196207T94-M2-Acetylcholine-LY2119620-chim(NtGi1-Go)/β1/γ2
9.09Single7UL3Famotidine7UL3-H2-Famotidine
9.09Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
9.09Single7UTZDPPC7UTZ-TSH-TR1402-DPPC-Gs/β1/γ2
9.09Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
9.09Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
9.09Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
9.09Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
9.09Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
9.09Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
9.09Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
9.09Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.09Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.09Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
9.09Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
9.09Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
9.09Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
9.09Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
9.09Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
9.09Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
9.09Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
9.09Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
9.09Single8K2WAMG4878K2W-CXCR3-AMG487
9.09Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
9.09Single8RLNLUF58348RLN-A2A-LUF5834
9.09Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
9.09Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.09Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
9.09Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.09Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.09Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
9.09Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
9.09Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
9.09Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.09Single8Y6YGLPG09748Y6Y-FFA2-GLPG0974
9.09Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
9.09Single8YRGFospropofol8YRG-MRGPRX4-Fospropofol-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
9.09Single9AS3LSD9AS3-5-HT2A-LSD
9.09Single9AS4LSD9AS4-5-HT2A-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single9AS5Mescaline9AS5-5-HT2A-Mescaline
9.09Single9AS6Mescaline9AS6-5-HT2A-Mescaline-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
9.09Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
9.09Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
9.09Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
9.09Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
9.09Consensusalpha1_onOrthosteric Ligandalpha1a_on
9.09Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
9.09Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
9.09Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
9.09Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
9.09Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
9.09Consensuscrf2_on_gpOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
9.09Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
9.09Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
9.09Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
9.09Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
9.09Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
9.09Consensusopsins_offOrthosteric Ligandrhodopsin_off
9.09Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
9.09Consensussensory_offOrthosteric Ligandopsins_off
8.82Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
8.82Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
8.70Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
8.70Single2Y02Carmoterol2Y02-β1-Carmoterol
8.70Single2Y04Salbutamol2Y04-β1-Salbutamol
8.70Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
8.70Single3NY8ICI118-5513NY8-β2-ICI118-551
8.70Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
8.70Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
8.70Single4GBRS-Carazolol4GBR-β2-S-Carazolol
8.70Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
8.70Single4MQSIperoxo4MQS-M2-Iperoxo
8.70Single4U14Tiotropium4U14-M3-Tiotropium
8.70Single4YAYZD-71554YAY-AT1-ZD-7155
8.70Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
8.70Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
8.70Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
8.70Single5T04Neurotensin5T04-NTS1-Neurotensin
8.70Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
8.70Single6GPSMK08126GPS-CCR2-MK0812
8.70Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
8.70Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
8.70Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
8.70Single6TOTLemborexant6TOT-OX1-Lemborexant
8.70Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.70Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
8.70Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
8.70Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
8.70Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
8.70Single7BU7BI1671077BU7-β1-BI167107
8.70Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
8.70Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
8.70Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
8.70Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
8.70Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
8.70Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
8.70Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
8.70Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
8.70Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
8.70Single7UL4Alvimopan7UL4-μ-Alvimopan
8.70Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
8.70Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
8.70Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
8.70Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
8.70Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
8.70Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
8.70Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
8.70Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
8.70Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
8.70Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
8.70Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
8.70Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
8.70Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
8.70Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
8.70Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
8.70Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
8.70Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
8.70Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
8.70Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
8.70Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
8.70Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
8.70Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
8.70Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
8.70Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
8.70Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
8.70Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
8.70Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
8.70Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
8.70Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
8.70Single8JJOAlprenolol8JJO-β2-Alprenolol
8.70Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
8.70Single8JXRLSD8JXR-D1-LSD
8.70Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
8.70Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
8.70Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
8.70Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
8.70Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
8.70Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
8.70Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
8.70Single8X63Mepyramine8X63-H1-Mepyramine
8.70Single8X64Desloratadine8X64-H1-Desloratadine
8.70Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
8.70Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
8.70Single9AS1DMT9AS1-5-HT2A-DMT
8.70Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
8.70Single9CHXS-Carazolol9CHX-β2-S-Carazolol
8.70Single9IMATalquetamab9IMA-GPRC5D-Talquetamab
8.70Single9JEAAtropine9JEA-M1-Atropine
8.70Single9JGKBalovaptan9JGK-5-HT2B-Balovaptan
8.70Single9PLNN-(5-methylnaphthalen-1-yl)pyridin-4-amine9PLN-α2a-N-(5-methylnaphthalen-1-yl)pyridin-4-amine
8.70Single9PLON-(5-methylnaphthalen-1-yl)pyridin-4-amine9PLO-α2a-N-(5-methylnaphthalen-1-yl)pyridin-4-amine-Go/β1/γ2
8.70Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
8.70Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
8.70Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
8.70Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
8.70Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
8.70Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
8.70Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
8.70Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
8.70Consensusblt_onOrthosteric Ligandblt1_on
8.70Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
8.70Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
8.70Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
8.70Consensusdopamine_offOrthosteric Ligandd2_off d3_off
8.70Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
8.70Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
8.70Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
8.70Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
8.70Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
8.70Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
8.70Consensushistamine_offOrthosteric Ligandh1_off
8.70Consensusleukotriene_onOrthosteric Ligandblt_on
8.70Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
8.70Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
8.70Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
8.70Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
8.57Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
8.57Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
8.57Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
8.57Consensusctlike_on_gpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
8.33Single2RH1S-Carazolol2RH1-β2-S-Carazolol
8.33Single2Y03Isoprenaline2Y03-β1-Isoprenaline
8.33Single4JKVTaladegib4JKV-SMO-Taladegib
8.33Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
8.33Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
8.33Single5JQHS-Carazolol5JQH-β2-S-Carazolol
8.33Single5WQCEMPA5WQC-OX2-EMPA
8.33Single6E67BI1671076E67-β2-BI167107-Gs(CT)
8.33Single6GPXMK08126GPX-CCR2-MK0812
8.33Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
8.33Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
8.33Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
8.33Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
8.33Single6TP6Filorexant6TP6-OX1-Filorexant
8.33Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
8.33Single7C4SS1P7C4S-S1P3-S1P
8.33Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
8.33Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
8.33Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
8.33Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
8.33Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
8.33Single8TF5Oleic acid8TF5-GPR6-Oleic acid
8.33Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Single9DYDAsenapine9DYD-5-HT1A-Asenapine-Go/β1/γ2
8.33Single9DYFAsenapine9DYF-5-HT1A-Asenapine-Gi1/β1/γ2
8.33Single9F34FOB02-04A9F34-D3-FOB02-04A-Go/β1/γ2
8.33Single9K07DSO-5a9K07-BB3-DSO-5a-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.33Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
8.33Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
8.33Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
8.33Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
8.33Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
8.33Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
8.33Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
8.33Consensusamine_offonOrthosteric Ligandamine_off amine_on
8.33Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
8.33Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
8.33Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
8.33Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
8.33Consensusclass-a_class-b1_cons_onOrthosteric Ligandclass-a_on class-b1_on
8.33Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
8.33Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
8.33Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
8.33Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
8.33Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
8.33Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
8.33Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.33Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.33Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
8.11Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
8.11Consensusglp1_onOrthosteric Ligand7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
8.00Single2YDVNECA2YDV-A2A-NECA
8.00Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
8.00Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
8.00Single4U15Tiotropium4U15-M3-Tiotropium
8.00Single4UHRCGS216804UHR-A2A-CGS21680
8.00Single5G53NECA5G53-A2A-NECA-Gs
8.00Single5V57TC1145V57-SMO-TC114
8.00Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
8.00Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
8.00Single6OL9Tiotropium6OL9-M5-Tiotropium
8.00Single6WGTLSD6WGT-5-HT2A-LSD
8.00Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
8.00Single7F1TMIP-1a7F1T-CCR5-MIP-1a
8.00Single7T9NDPPC7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
8.00Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
8.00Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
8.00Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
8.00Single8JD5JNJ-40411813; ADX881788JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
8.00Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
8.00Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
8.00Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Gi1/β1/γ1
8.00Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
8.00Single9AS9RS130-1809AS9-5-HT2A-RS130-180
8.00Single9ASARS130-1809ASA-5-HT2A-RS130-180-chim(NtGi1-Gs-CtGq)/β1/γ2
8.00Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
8.00Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
8.00Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
8.00Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
8.00Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
8.00Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
8.00Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
8.00Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
8.00Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
7.89Consensuscrf_on_gpOrthosteric Ligandcrf2_on_gp crf1_on_gp
7.89Consensusglp1_on_gpOrthosteric Ligand7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
7.89Consensuspth1_on_gpOrthosteric Ligand6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
7.69Single4AMIBucindolol4AMI-β1-Bucindolol
7.69Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
7.69Single5CXVTiotropium5CXV-M1-Tiotropium
7.69Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
7.69Single6A93Risperidone6A93-5-HT2A-Risperidone
7.69Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
7.69Single6CM4Risperidone6CM4-D2-Risperidone
7.69Single6OS2TRV0266OS2-AT1-TRV026
7.69Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
7.69Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
7.69Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
7.69Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
7.69Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
7.69Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
7.69Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
7.69Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
7.69Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
7.69Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
7.69Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
7.69Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
7.69Single8XYIVUF106618XYI-CXCR3-VUF10661
7.69Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
7.69Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
7.69Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
7.69Consensusalpha1_offOrthosteric Ligandalpha1a_off
7.69Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
7.69Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
7.69Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
7.69Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
7.69Consensusclass-a_class-b1_cons_on_gpOrthosteric Ligandclass-a_on_gp class-b1_on_gp
7.69Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
7.50Consensuspth_onOrthosteric Ligandpth1_on pth2_on
7.41Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
7.41Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
7.41Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
7.41Single6H7LDobutamine6H7L-β1-Dobutamine
7.41Single6IBLArformoterol6IBL-β1-Arformoterol
7.41Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
7.41Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
7.41Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
7.41Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
7.41Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
7.41Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
7.41Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
7.41Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
7.41Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
7.41Consensuschemerin_onOrthosteric Ligandcml1_on
7.41Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
7.14Single7SK9CCX6627SK9-ACKR3-CCX662
7.14Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
7.14Single8X5YAstemizole8X5Y-H1-Astemizole
7.14Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
6.90Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
6.90Single8YWFRetatrutide8YWF-GLP-1-Retatrutide-chim(NtGi1-Gs)/β1/γ2
6.82Consensuspth_on_gpOrthosteric Ligandpth1_on_gp pth2_on_gp
6.67Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
6.67Single8W8SAA-148W8S-GPR101-AA-14
6.67Single9IQVMuscarinic toxin 39IQV-Alpha1A-Muscarinic toxin 3
6.45Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
6.45Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
6.45Single9B5YLong-Acting PTH9B5Y-PTH1-Long-Acting PTH-chim(NtGi1-Gq)/β1/γ2
6.45Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
6.45Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
6.25Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
6.25Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
6.25Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
6.25Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
6.25Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
6.25Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
6.25Single8W8RAA-148W8R-GPR101-AA-14-chim(NtGi1-Gs)/β1/γ2
6.25Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ2
6.25Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
6.06Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
6.06Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
6.06Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
6.06Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
6.06Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
6.06Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
6.06Consensusvpac1_onOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
6.06Consensusvpac_onOrthosteric Ligandvpac1_on vpac2_on
5.88Single5MZPCaffeine5MZP-A2A-Caffeine-Na
5.88Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
5.88Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
5.88Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
5.88Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
5.88Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
5.88Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
5.88Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
5.88Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/β1/γ2
5.88Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
5.88Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
5.88Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
5.88Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
5.88Consensuspac1_onOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
5.88Consensuspac1_on_gpOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
5.88Consensuspac_on_gpOrthosteric Ligandpac1_on_gp
5.88Consensussecretin_onOrthosteric Ligand7D3S-Secretin-Secretin-Gs/β1/γ2
5.88Consensusvpac1_on_gpOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
5.88Consensusvpac_on_gpOrthosteric Ligandvpac1_on_gp vpac2_on_gp
5.71Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
5.71Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
5.71Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
5.71Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
5.71Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
5.71Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
5.71Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
5.71Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
5.71Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
5.71Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
5.71Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
5.71Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
5.71Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
5.71Consensusglp2_on_gpOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
5.71Consensusglp_onOrthosteric Ligandglp1_on glp2_on
5.71Consensusglp_on_gpOrthosteric Ligandglp1_on_gp glp2_on_gp
5.71Consensussecretin_on_gpOrthosteric Ligand7D3S-Secretin-Secretin-Gs/β1/γ2
5.56Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
5.56Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
5.56Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
5.56Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
5.56Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
5.56Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
5.56Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
5.56Single7V68LY21196207V68-M4-Iperoxo-LY2119620-Gi1/β1/γ2
5.56Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
5.56Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
5.56Single7WC4Serotonin7WC4-5-HT2A-Serotonin
5.56Single7XKDBeta-Hydroxyandrosterone7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
5.56Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
5.56Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
5.56Single8PWNTheophylline8PWN-A2A-Theophylline
5.56Single9BYOExendin-39BYO-GLP-1-Exendin-3-Gs/β1/γ2
5.56Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
5.56Consensuspth1_onOrthosteric Ligand6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
5.56Consensusvip-pacap_onOrthosteric Ligandvpac_on pac_on
5.56Consensusvip-pacap_on_gpOrthosteric Ligandvpac_on_gp pac_on_gp
5.56Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
5.56Consensusvpac2_on_gpOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
5.41Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
5.41Consensusgip_onOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
5.41Consensusgip_on_gpOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
5.26Single3OE8IT1t3OE8-CXCR4-IT1t
5.26Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
5.26Single6OY9All-trans-Retinal6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
5.26Single6TQ9SB-4081246TQ9-OX1-SB-408124
5.26Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.26Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
5.26Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.26Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
5.26Single8IKGQ2B8IKG-CB1-Q2B-Gi1/β1/γ1
5.26Single8IWM2-Phenylethylamine8IWM-TA9-2-Phenylethylamine
5.26Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26Single9CHUNoradrenaline9CHU-β2-Noradrenaline
5.26Single9EE9Adenosine9EE9-A2A-Adenosine-Gs/β1/γ2
5.26Consensusgs_histamineOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
5.26Consensush2_onOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
5.13Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
5.13Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
5.13Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
5.13Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
5.13Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
5.13Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.00Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
5.00Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
5.00Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
5.00Single3OE6IT1t3OE6-CXCR4-IT1t
5.00Single3PQRAll-trans-Retinal3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
5.00Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
5.00Single6ME5Agomelatine6ME5-MT1-Agomelatine
5.00Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
5.00Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
5.00Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
5.00Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.00Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
5.00Single8IW72-Phenylethylamine8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
5.00Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
5.00Single8J6QCompound 9n8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
5.00Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
5.00Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
5.00Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
5.00Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
5.00Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
5.00Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
5.00Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single8WG8Peptide8WG8-Glucagon-Peptide-chim(NtGi1-Gs)/β1/γ2
5.00Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
5.00Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
5.00Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
5.00Single9LRCHistamine9LRC-H4-Histamine
5.00Single9LREHistamine9LRE-H4-Histamine-Gi1/β1/γ2
5.00Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
5.00Consensusgi_sensoryOrthosteric Ligandgi_opsins
5.00Consensusglucagon_onOrthosteric Ligandglp_on gluc_on secretin_on gip_on
5.00Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
5.00Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
5.00Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
5.00Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
5.00Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
5.00Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
5.00Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
5.00Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
4.88Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
4.88Consensusgluc_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
4.88Consensusglucagon_on_gpOrthosteric Ligandglp_on_gp gluc_on_gp secretin_on_gp gip_on_gp
4.76Single3OE9IT1t3OE9-CXCR4-IT1t
4.76Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
4.76Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
4.76Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
4.76Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.76Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
4.76Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
4.76Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
4.76Single8IKHQ2L8IKH-CB1-Q2L-Gi1/β1/γ1
4.76Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
4.76Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/β1/γ2
4.76Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
4.76Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
4.76Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
4.76Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
4.76Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
4.76Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
4.76Single8YN7Immethridine8YN7-H3-Immethridine-Go/β1/γ2
4.76Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
4.76Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
4.76Single9AS2DMT9AS2-5-HT2A-DMT-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Single9E7RGB889E7R-PAR2-GB88-chim(NtGi1L-Gs-CtGq)/β1/γ2
4.76Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
4.76Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
4.76Single9IZDCHBA9IZD-HCA1-CHBA-Gi1/β1/γ2
4.76Consensusgluc_on_gpOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
4.76Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
4.65Consensusclass-b1_onOrthosteric Ligandglucagon_on vip-pacap_on pth_on crf_on calcitonin_on
4.55Single4BWBNeurotensin4BWB-NTS1-Neurotensin
4.55Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
4.55Single6ME2Ramelteon6ME2-MT1-Ramelteon
4.55Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
4.55Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
4.55Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
4.55Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
4.55Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
4.55Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
4.55Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
4.55Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
4.55Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
4.55Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
4.55Single7WV9ZCZ0117WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
4.55Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
4.55Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
4.55Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
4.55Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.55Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
4.55Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
4.55Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
4.55Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
4.55Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
4.55Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
4.55Single8IWESpermidine8IWE-TA9-Spermidine
4.55Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
4.55Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
4.55Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
4.55Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.55Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.55Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.55Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
4.55Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
4.55Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
4.55Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
4.55Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
4.55Single8Y0HVUF114188Y0H-CXCR3-VUF11418
4.55Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go/β1/γ2
4.55Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ2
4.55Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
4.55Single8YYWAlpha-ketoglutarate8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
4.55Consensusangiotensin_offOrthosteric Ligandat1_off
4.55Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
4.55Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
4.55Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
4.55Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
4.55Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
4.55Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
4.55Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
4.35Single2YDOAdenosine2YDO-A2A-Adenosine
4.35Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
4.35Single6A94Zotepine6A94-5-HT2A-Zotepine
4.35Single6KUXRS-799486KUX-α2a-RS-79948
4.35Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
4.35Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
4.35Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
4.35Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
4.35Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
4.35Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
4.35Single7F61PF-036547467F61-H3-PF-03654746
4.35Single7T94Acetylcholine7T94-M2-Acetylcholine-LY2119620-chim(NtGi1-Go)/β1/γ2
4.35Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
4.35Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
4.35Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
4.35Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
4.35Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
4.35Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
4.35Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
4.35Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
4.35Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
4.35Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
4.35Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.35Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
4.35Single8IHKAcifran8IHK-HCA3-Acifran
4.35Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
4.35Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
4.35Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
4.35Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
4.35Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
4.35Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
4.35Single8K5CAcipimox8K5C-HCA2-Acipimox
4.35Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.35Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
4.35Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.35Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.35Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
4.35Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
4.35Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
4.35Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35Single8ZPMAMD0708ZPM-CXCR4-AMD070
4.35Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
4.35Single9K0KUTP9K0K-P2Y4-UTP-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35Single9K0XATP9K0X-P2Y2-ATP-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35Single9K20ATP9K20-P2Y2-ATP-chim(NtGi1-Go)/β1/γ2
4.35Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
4.35Consensushca_onOrthosteric Ligandhca2_on
4.26Consensusclass-b1_on_gpOrthosteric Ligandglucagon_on_gp vip-pacap_on_gp pth_on_gp crf_on_gp calcitonin_on_gp
4.17Single2Y01Dobutamine2Y01-β1-Dobutamine
4.17Single4DAJTiotropium4DAJ-M3-Tiotropium
4.17Single4QKX35V4QKX-β2-35V
4.17Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
4.17Single5DSGTiotropium5DSG-M4-Tiotropium
4.17Single5TGZAM65385TGZ-CB1-AM6538
4.17Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
4.17Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
4.17Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
4.17Single6D27CAY104716D27-DP2-CAY10471
4.17Single6H7MSalbutamol6H7M-β1-Salbutamol
4.17Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/β1/γ2
4.17Single7F83PF-051904577F83-Ghrelin-PF-05190457
4.17Single7WC7Lisuride7WC7-5-HT2A-Lisuride
4.17Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
4.17Single7YXAONO-54306087YXA-S1P5-ONO-5430608
4.17Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
4.17Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
4.17Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
4.17Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
4.17Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
4.17Single8K5DGSK2560738K5D-HCA2-GSK256073
4.17Single8PJKST1718PJK-5-HT1A-ST171-Gi1/β1/γ1
4.17Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
4.17Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
4.17Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
4.17Single8Y73MPAM-158Y73-μ-Peptide-MPAM-15-Gi1/β1/γ2
4.17Single8YN8Proxyfan8YN8-H3-Proxyfan-Go/β1/γ2
4.17Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
4.17Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
4.17Single9IZCMK19039IZC-HCA2-MK1903-Gi1/β1/γ2
4.17Single9KFJPubChem 1383196749KFJ-RXFP3-PubChem 138319674-Gi2/β1/γ2
4.17Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
4.17Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
4.17Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
4.17Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
4.17Consensushca_on_gpOrthosteric Ligandhca2_on_gp
4.17Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
4.00Single2Y00Dobutamine2Y00-β1-Dobutamine
4.00Single5T1ABMS-6815T1A-CCR2-BMS-681-PubChem 12093170
4.00Single5WIUNemonapride5WIU-D4-Nemonapride
4.00Single5WIVNemonapride5WIV-D4-Nemonapride-Na
4.00Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
4.00Single6D26Fevipiprant6D26-DP2-Fevipiprant
4.00Single6LUQHaloperidol6LUQ-D2-Haloperidol
4.00Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
4.00Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
4.00Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.00Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
4.00Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
4.00Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
4.00Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
4.00Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
4.00Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
4.00Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
4.00Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
4.00Single8XYKVUF106618XYK-CXCR3-VUF10661-Go/β1/γ2
4.00Single8ZMFA1L108ZMF-5-HT2C-A1L10
4.00Single9CIBFCH-22964139CIB-HCA2-FCH-2296413
4.00Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
4.00Single9F33FOB02-04A9F33-D3-FOB02-04A-Go/β1/γ2
4.00Single9HC04YI9HC0-mGlu5-4YI
4.00Consensusadgrg2_onOrthosteric Ligand7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
4.00Consensusadgrg2_on_gpOrthosteric Ligand7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
4.00Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
4.00Consensusblt_offOrthosteric Ligandblt1_off
4.00Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
4.00Consensusdp_offOrthosteric Liganddp2_off
4.00Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
4.00Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
4.00Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
4.00Consensustrace-amine_onOrthosteric Ligandta1_on
3.85Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
3.85Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
3.85Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
3.85Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
3.85Single7P2L4YI7P2L-mGlu5-4YI
3.85Single8EA0Iperoxo8EA0-M3-Iperoxo
3.85Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
3.85Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
3.85Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
3.85Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
3.85Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
3.85Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
3.85Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
3.85Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
3.70Single4N4WSANT-14N4W-SMO-SANT-1
3.70Single5X33BIIL2605X33-BLT1-BIIL260
3.70Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
3.70Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
3.70Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
3.70Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
3.70Single7K15MKD0467K15-BLT1-MKD046-Na
3.70Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
3.70Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
3.70Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
3.70Single9BJKNAM9BJK-μ-Naloxone-NAM
3.70Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
3.70Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
3.57Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
3.57Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
3.57Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
3.57Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
3.57Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
3.57Single9C0KExendin-49C0K-GLP-1-Exendin-4-Gs/β1/γ2
3.57Consensusprostanoid_offOrthosteric Ligandep_off dp_off
3.45Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
3.45Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
3.45Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
3.33Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
3.33Single9BUECagrilintide9BUE-CT-Cagrilintide-Gs/β1/γ2
3.23Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
3.23Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
3.23Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
3.12Consensusclass-b1_class-b2_cons_onOrthosteric Ligandclass-b1_on class-b2_on
3.12Consensusclass-b1_class-b2_cons_on_gpOrthosteric Ligandclass-b1_on_gp class-b2_on_gp
3.03Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
3.03Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
3.03Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
3.03Single9EBOGLP-1 (ACPC18)9EBO-GLP-1-GLP-1 (ACPC18)-Gs/β1/γ2
2.94Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
2.94Consensuspac_onOrthosteric Ligandpac1_on
2.86Single6FJ3PTH6FJ3-PTH1-PTH
2.86Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
2.86Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
2.86Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
2.86Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
2.86Single9BLBCagrilintide backbone (non-acylated)9BLB-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
2.86Single9BLWCagrilintide backbone (non-acylated)9BLW-CT (AMY1)-Cagrilintide backbone (non-acylated)-Gs/β1/γ2; RAMP1
2.78Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
2.78Single9BUCCagrilintide9BUC-CT-Cagrilintide-Gs/β1/γ2
2.70Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
2.70Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
2.70Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
2.70Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
2.70Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
2.63Single7RBTTirzepatide7RBT-GIP-Tirzepatide-LSN3556672-chim(NtGi1-Gs)/β1/γ2
2.63Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
2.56Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
2.44Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
2.44Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2

Consensus Members
Id Members
7XXI 7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
Net Summary
Imin 2.77
Number of Linked Nodes 875
Number of Links 1140
Number of Hubs 207
Number of Links mediated by Hubs 736
Number of Communities 28
Number of Nodes involved in Communities 315
Number of Links involved in Communities 473
Path Summary
Number Of Nodes in MetaPath 73
Number Of Links MetaPath 72
Number of Shortest Paths 2229899
Length Of Smallest Path 3
Average Path Length 28.0791
Length of Longest Path 52
Minimum Path Strength 1.25
Average Path Strength 5.73172
Maximum Path Strength 25.41
Minimum Path Correlation 0.7
Average Path Correlation 0.987355
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 4.7619
Average % Of Corr. Nodes 42.8475
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 56.6192
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following consensuses:
IdComponents
p2y_on_gpp2y1_on_gp
p2y10_on_gp
p2y12_on_gp



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