Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
1G.s1h1.04 5.837084179
2G.S3.03 5.517086118
3G.S3.04 8.948124167
4G.S3.06 9.208675167
5G.H2.01 5.20563409
6G.H2.06 5.52107729
7G.H2.07 6.31233529
8G.S4.04 4.57375409
9G.H3.01 4.523616179
10G.H3.09 5.40256209
11G.H3.13 9.49555206
12G.H3.17 10.8235525
13G.S5.03 4.84229409
14G.S5.04 4.81917409
15G.S5.05 5.590424129
16G.S5.07 3.67042409
17G.hgh4.05 11.545406
18G.hgh4.20 5.59403
19G.hgh4.21 5.68729404
20G.H4.03 2.96188404
21G.H4.08 7.477294103
22G.H4.10 9.4165507
23G.H4.12 7.207175104
24G.H4.15 8.09208408
25G.h4s6.12 4.18708402
26G.h4s6.20 6.84792454
27G.S6.01 3.90875405
28G.S6.02 7.75183558
29G.S6.05 8.562175105
30G.s6h5.01 6.029174129
31G.H5.03 5.238675129
32G.H5.06 6.815835124
33G.H5.08 5.616396118
34G.H5.17 10.184455
35G.H5.19 6.04438448
36G.H5.20 4.84417408
37G.H5.23 8.58417544
38b.1x1 1.76771404
39b.lhb1x6 4.244213
40b.l1x3 9.41233599
41b.l1x6 9.65817529
42b.b2x1 6.768528
43b.b2x5 7.95067507
44b.l3x1 7.96104429
45b.l3x2 5.972835199
46b.b4x6 8.99869799
47b.b5x2 6.24875407
48b.b5x3 5.5419799
49b.b5x5 5.529174245
50b.b5x7 5.70375407
51b.l5x1 4.832335238
52b.l5x5 10.4838509
53b.b6x1 4.78625429
54b.b6x5 4.50117506
55b.l6x5 6.401874184
56b.b7x1 5.75255184
57b.b8x4 6.1875406
58b.l9x3 7.54533589
59b.l9x6 5.38365828
60b.b10x5 5.13533509
61b.l11x2 8.11771489
62b.b12x6 7.74726788
63b.b13x7 8.44233577
64b.l13x3 7.24542679
65b.l13x6 6.19771429
66b.l13x7 4.73958479
67b.b14x3 5.37625475
68b.b15x1 6.94778679
69b.l15x2 5.8225409
70b.b16x4 8.924576
71b.b16x6 9.22778678
72b.b17x7 9.62896438
73b.l17x3 8.94083639
74b.l17x6 8.97146429
75b.b18x3 5.33042438
76b.l18x1 6.081557136
77b.l18x2 6.578964137
78b.b19x2 7.34861636
79b.b19x4 5.72854438
80b.l19x1 5.92562429
81b.l19x2 7.01867539
82b.b20x4 10.133538
83b.b20x6 7.80533536
84b.l20x2 6.71375409
85b.b21x1 9.67083437
86b.b21x7 7.17583505
87b.l21x2 5.11813404
88b.b22x5 5.308066137
89b.l22x5 7.306464219
90b.b23x6 7.15625607
91b.l23x1 6.19967526
92b.l25x3 8.37283569
93b.l25x6 14.03528
94b.l27x1 11.0056729
95b.l27x2 6.45688469
96b.b28x2 4.8865564
97b.b28x3 5.11667497
98b.b28x4 7.01333566
99b.b28x6 9.3445569
100g.h1x1 1.25117502
101g.h1x11 2.87542409
102g.l1x4 5.33417408
103g.h2x11 8.470214136
104g.ctx3 5.6515509
105g.ctx14 5.254584149
106g.ctx15 6.199584149
107g.ctx16 4.74268148
108Lig 10.25462610
109NT 3.919921013
1101x39 5.74067516
1111x40 1.84167505
1121x50 4.90813409
113I1x50 6.873964158
1142x40 6.145696158
1152x42 5.09407
1162x46 4.6575449
1172x50 6.28983549
1182x61 4.10208415
119E1 2.1395503
1203x28 3.17813405
1213x29 10.3577415
1223x50 9.58917449
1233x54 5.44292408
1243x55 11.8356456
125I2x53 8.21833408
1264x50 4.95083409
1274x60 5.00625405
1284x61 5.10817515
1295x47 8.545175257
1305x58 5.13767508
1315x64 5.80562456
1325x68 7.63208458
1336x44 5.82754258
1346x48 7.600696257
1356x51 6.10167515
1366x54 6.99146414
1376x55 4.57104415
1386x61 4.75875413
139E3 12.0869913
1407x34 10.2529414
1417x37 6.92458415
1427x49 6.64917449
1437x52 3.94167448
1447x53 5.69167549
1458x50 4.008134158
146I3 5.64188400
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1b.b3x6 b.l1x3 22.9412.9008NoYes099
2b.b3x6 b.l3x2 23.10687.85083NoYes099
3b.b4x6 b.l1x3 17.67474.05417YesYes999
4G.HN.51 b.l1x4 88.15536.84NoNo046
5G.HN.51 G.hns1.02 87.985310.3142NoNo044
6G.H5.09 G.H5.12 10.47818.83833NoNo047
7G.H5.12 G.H5.16 10.12745.255NoNo076
83x55 5x64 31.17474.94667YesYes566
93x54 3x55 32.66966.17667YesYes086
103x54 G.H5.23 33.094.33583YesYes084
113x53 G.H5.23 74.94466.26667NoYes494
123x53 I2x53 75.61529.715NoYes098
13I2x53 I2x54 87.81487.8925YesNo085
14G.hns1.02 I2x54 87.90018.77167NoNo045
15G.hns1.01 b.l3x2 17.2245.45917NoYes1949
16G.S1.03 G.hns1.01 98.481216.3767NoNo094
17G.S1.03 G.S3.06 98.5443.92083NoYes097
185x64 5x68 21.09326.89083YesYes568
195x68 G.H5.17 21.664511.2842YesYes585
20G.H5.17 G.S6.02 20.957712.0908YesYes558
21G.H5.10 G.S6.02 20.466910.535NoYes078
22G.S3.06 b.l5x5 99.278619.5442YesYes079
23G.S5.05 G.s6h5.01 11.12027.45917YesYes1299
24G.S5.07 G.s6h5.01 16.14544.02167YesYes099
25G.S5.07 G.s5hg.01 10.6895.24833YesNo099
26G.H5.10 G.S6.04 13.105311.1358NoNo079
27b.l3x1 b.l5x5 1007.66583YesYes099
28G.H2.10 b.l3x1 41.00794.83333NoYes289
29G.H2.10 b.b6x1 40.99393.645NoYes289
30b.b6x1 b.l9x6 89.02036.6825YesYes298
31b.b2x1 b.l3x1 49.933213.245YesYes289
32b.b2x1 b.b6x1 48.20544.88917YesYes289
33G.H2.07 b.l9x6 33.51713.5375YesYes298
34G.H2.06 b.l9x6 47.24863.48083YesYes298
35G.H2.04 G.H2.07 32.77798.66583NoYes099
36G.H2.06 b.l19x1 46.55584.60917YesYes299
37G.H3.17 b.l27x1 12.57427.10667YesYes259
38b.l25x6 b.l27x1 11.676121.49YesYes289
39b.b2x1 b.l27x1 16.00724.3375YesYes289
40G.H2.04 G.H3.08 32.6156.22333NoNo098
41G.H3.08 G.S4.04 32.30834.12333NoYes089
42G.S4.04 G.S5.04 22.14663.95583YesYes099
43G.S5.06 G.S6.05 14.65174.76917NoYes085
44G.S5.04 G.S5.06 14.82334.0375YesNo098
45G.H4.10 G.hgh4.05 12.403616.97YesYes076
46G.H4.10 G.hgh4.08 18.789411.0033YesNo076
47G.H4.13 G.hgh4.08 14.60419.86333NoNo036
48G.H4.12 G.H4.13 15.13067.64417YesNo043
49G.H4.12 G.S6.03 10.44216.0025YesNo1045
50G.S6.01 G.S6.03 12.4593.61YesNo055
51G.H3.17 b.l23x1 11.17656.42083YesYes256
52b.l23x1 b.l25x6 11.146915.3858YesYes268
533x50 G.H5.23 44.620522.2925YesYes494
54b.l17x5 b.l19x1 46.68533.55583NoYes069
55b.l17x5 b.l19x2 46.53723.68083NoYes069
56b.l17x3 b.l19x2 31.90435.775YesYes399
57b.b19x4 b.l17x3 17.42157.18667YesYes389
58b.b19x4 b.b20x6 13.35667.24083YesYes386
59b.b17x7 b.b20x6 33.409111.0742YesYes386
60b.b17x7 b.b21x1 27.85247.46167YesYes387
61b.1x19 b.b21x1 20.761811.415NoYes067
62b.1x15 b.1x19 18.71686.57833NoNo076
63b.1x15 g.h1x11 17.18141.665NoYes079
64b.1x11 g.h1x11 15.64455.6525NoYes089
65b.b20x4 b.l17x3 13.848817.0192YesYes389
66b.b20x4 b.b20x6 26.68333.74167YesYes386
67b.b20x2 b.l19x2 14.16868.43333NoYes069
68b.b20x2 b.b20x4 13.84378.625NoYes068
69b.1x11 g.h1x12 13.59322.7025NoNo086
70g.h1x12 g.h1x9 12.56663.9375NoNo066
71g.h1x5 g.h1x9 11.53941.6475NoNo066
72g.h1x1 g.h1x5 11.02561.98417YesNo026
73b.l21x7 b.l23x1 21.61713.50083NoYes056
74b.b23x6 b.l21x7 20.19353.02333YesNo075
75b.b23x6 b.b24x6 15.52596.19083YesNo078
76b.b21x7 b.b24x6 14.826611.335YesNo058
77b.b3x2 b.b4x6 13.01413.98667NoYes059
78b.b2x5 b.b3x2 12.840315.85YesNo075
793x49 I2x53 16.84887.66333NoYes098
802x39 3x49 11.38285.1975NoNo089
812x39 2x40 11.20025.98583NoYes088
82b.b10x1 b.l9x6 26.74533.17833NoYes098
83b.b10x1 b.b11x5 26.57854.34667NoNo096
84b.b11x5 b.b14x3 20.23156.7575NoYes065
85b.b10x2 b.b14x3 17.05926.61167NoYes065
86b.b21x7 b.b23x2 11.96175.3725YesNo056
87b.b22x5 b.b23x2 11.601810.8592YesNo076
883x50 5x58 33.13696.60167YesYes098
895x54 5x58 36.72024.87667NoYes088
905x54 6x44 36.5795.7825NoYes088
915x47 6x44 17.52985.27YesYes2578
925x47 6x52 17.077524.3025YesNo075
936x51 6x52 16.926.69917YesNo055
946x51 Lig 29.68475.5825YesYes150
956x44 6x48 18.35547.18167YesYes2587
966x48 7x41 18.21558.025YesNo077
976x51 7x41 18.05236.06917YesNo057
981x50 2x50 11.06187.18083YesYes099
993x50 7x53 11.10335.91333YesYes499
100G.hns1.01 b.l1x4 81.19416.05583NoNo1946
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
2x64Lig11.18331NoYes3010
3x25Lig18.60251NoYes6010
1x39Lig9.374171YesYes6010
2x60Lig9.261NoYes4010
2x61Lig4.685831YesYes5010
7x35Lig6.084171NoYes4010
7x38Lig4.960831NoYes4010
3x29Lig21.69581YesYes5010
3x32Lig11.71251NoYes5010
4x61Lig9.51251YesYes5010
6x51Lig5.58251YesYes5010
7x34Lig14.85751YesYes4010
E2Lig6.530830NoYes4010
5x40Lig8.741NoYes4010
5x43Lig3.78251NoYes5010
6x55Lig4.709171YesYes5010
6x58Lig7.770830NoYes4010
E3Lig4.155831YesYes3010
NTNT6.180831YesYes3311
E3NT8.20751YesYes3311
7x33NT4.508331NoYes4321
7x35NT4.961NoYes4311
1x397x383.451671YesNo6411
1x397x424.77251YesNo6612
2x563x326.800830NoNo5521
2x573x327.579170NoNo7521
2x577x425.436670NoNo7622
2x603x287.568331NoYes4512
2x603x297.471671NoYes4511
3x253x298.758331NoYes6511
3x294x613.5051YesYes5511
3x304x616.064170NoYes5521
4x605x434.974170YesNo5521
5x406x554.424171NoYes4511
5x406x597.05251NoNo4412
6x516x526.699171YesNo5512
6x516x556.619171YesYes5511
6x517x345.538331YesYes5411
6x517x416.069171YesNo5712
6x54E39.258331YesYes4321
6x547x3413.1051YesYes4421
6x547x375.1651YesYes4522
6x57E314.851NoYes4321
6x61E311.17831YesYes3321
E3E323.70751YesYes3311
7x37E310.881YesYes5321
7x337x374.741NoYes4522
7x347x387.510831YesNo4411
4x64Lig10.17330NoYes0010
LigNT3.543331YesYes0301
1x392x616.771671YesYes6511
1x397x394.333331YesNo6512
6x576x614.85751NoYes4322
3x21Lig3.378331NoYes6010
3x334x613.271670NoYes4521
3x264x613.18750NoYes4521
6x53E32.83751NoYes6321
2x673x212.75250NoNo3621
3x22Lig2.5951NoYes2010
1x402x612.540YesYes5521
5x446x552.531670NoYes4521
2x63Lig2.518330NoYes4010
7x36NT2.4550NoYes3321
1x362x612.410830NoYes3521
1x38NT2.270NoYes5321
3x223x231.986671NoNo2112
2x642x681.168331NoNo3312
3x18Lig0.9241670NoYes3010
7x29NT0.6066670NoYes0321
7x32NT0.2866670NoYes0321

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
92.31Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
92.31Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
75.00Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
74.07Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
70.83Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
70.83Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
68.00Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
68.00Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
65.38Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
63.64Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
63.64Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
62.96Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
62.07Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
60.71Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
60.71Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
60.71Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
59.38Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
59.26Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
58.33Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
57.69Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
57.69Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
57.14Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
56.00Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
55.56Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
53.85Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
53.85Single8QJ2pN1628QJ2-MC4-pN162-Gs
53.57Single6W25SHU91196W25-MC4-SHU9119-Ca
53.57Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
53.57Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
51.85Single8KIGSHU91198KIG-MC3-SHU9119-Ca
51.85Single8WKYPG-9348WKY-MC4-PG-934
50.00Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
48.00Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
46.88Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
46.88Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
46.88Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
46.15Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
45.16Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
43.75Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
43.75Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
43.33Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
43.33Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
43.33Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
42.86Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
42.31Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
42.31Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
41.94Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
41.38Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
41.38Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
41.38Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
41.38Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
40.74Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
40.74Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
40.74Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
40.00Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
40.00Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
40.00Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
40.00Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
40.00Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
40.00Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
40.00Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
40.00Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
40.00Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
39.39Single7SK3CXCL127SK3-ACKR3-CXCL12
39.39Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
39.39Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
39.39Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
39.29Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
39.29Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
39.29Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
39.29Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
38.89Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
38.71Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
38.71Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
38.46Single5N2SPSB365N2S-A1-PSB36
38.24Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
38.24Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
38.24Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
38.24Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
38.24Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
38.24Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
37.93Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
37.93Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
37.93Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
37.93Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
37.93Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
37.93Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
37.93Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
37.93Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
37.50Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
37.50Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
37.50Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
37.50Single7XRRLemborexant7XRR-OX2-Lemborexant
37.50Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
37.50Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
37.50Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
37.50Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
37.50Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
37.50Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
37.50Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
37.50Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
37.14Single6IGLIRL16206IGL-ETB-IRL1620
37.04Single5XRAAM115425XRA-CB1-AM11542
37.04Single7FEECP559407FEE-CB1-CP55940-ZCZ011
37.04Single7TUYGSK682753A7TUY-GPR183-GSK682753A
37.04Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
37.04Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
37.04Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
36.67Single7F8XNN90567F8X-CCKA-NN9056
36.67Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
36.67Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
36.67Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/β1/γ2
36.67Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
36.67Consensuslpl_onOrthosteric Ligands1p_on lpa_on
36.67Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
36.67Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
36.67Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
36.36Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
36.36Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
36.36Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
36.36Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
36.36Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
36.36Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
36.36Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
36.36Single8ZRTET-18ZRT-ETB-ET-1
36.36Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
36.36Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
36.36Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
36.36Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
36.11Single5GLHEndothelin-15GLH-ETB-Endothelin-1
36.11Single6IGKEndothelin-36IGK-ETB-Endothelin-3
35.71Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
35.71Single6KQICP559406KQI-CB1-CP55940-Org27569
35.71Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
35.71Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
35.71Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
35.71Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
35.71Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
35.71Consensuslpa_offOrthosteric Ligandlpa1_off
35.71Consensuslpl_offOrthosteric Ligands1p_off lpa_off
35.71Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
35.71Consensusorexin_onOrthosteric Ligandox2_on
35.48Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
35.48Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
35.48Single7SK5CXCL127SK5-ACKR3-CXCL12
35.48Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
35.48Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
35.48Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
35.48Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
35.29Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
35.29Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
35.29Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
35.29Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
35.29Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
35.29Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
35.29Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
35.14Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
34.62Single7V3ZCP559407V3Z-CB1-CP55940
34.62Consensuscck_offOrthosteric Ligandccka_off
34.62Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
34.48Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
34.48Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
34.48Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
34.48Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
34.48Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
34.48Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
34.48Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
34.48Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
34.48Consensuscck_onOrthosteric Ligandccka_on cckb_on
34.48Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
34.48Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
34.48Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
34.48Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
34.48Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
34.48Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
34.48Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
34.48Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
34.38Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
34.38Single6PT2KGCHM076PT2-δ-KGCHM07
34.38Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
34.38Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
34.38Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
34.38Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
34.38Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
34.38Consensusangiotensin_onOrthosteric Ligandat1_on
34.38Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
34.38Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
34.38Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
34.38Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
34.38Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
34.29Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
34.21Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
33.33Single5N2RPSB-365N2R-A2A-PSB-36-Na
33.33Single5ZTYAM102575ZTY-CB2-AM10257
33.33Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
33.33Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
33.33Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
33.33Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
33.33Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
33.33Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
33.33Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
33.33Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
33.33Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
33.33Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
33.33Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
33.33Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
33.33Single8GNEKW-63568GNE-A2A-KW-6356-Na
33.33Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single8IY6Endothelin-18IY6-ETB-Endothelin-1
33.33Single8TF5Oleic acid8TF5-GPR6-Oleic acid
33.33Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
33.33Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
33.33Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
33.33Consensusadenosine_offOrthosteric Liganda1_off a2_off
33.33Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
33.33Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
33.33Consensusbradykinin_onOrthosteric Ligandbk2_on
33.33Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
33.33Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
33.33Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
33.33Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
33.33Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
33.33Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
33.33Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
33.33Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
33.33Consensusendothelin_onOrthosteric Ligandetb_on eta_on
33.33Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
33.33Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
33.33Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
33.33Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
33.33Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
33.33Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
32.43Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
32.35Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
32.35Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
32.35Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
32.35Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
32.35Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
32.26Single4XT1Fractalkine4XT1-US28-Fractalkine
32.26Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
32.26Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
32.26Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
32.26Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
32.26Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
32.26Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
32.26Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
32.26Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
32.26Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
32.14Single5XR8AM8415XR8-CB1-AM841
32.14Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
32.14Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
32.14Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
32.14Single8E0GBU728E0G-μ-BU72
32.14Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
32.14Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
32.14Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
32.14Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
32.14Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
32.14Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
32.14Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
32.14Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
32.14Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
32.14Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
32.14Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
32.14Consensuslpa_onOrthosteric Ligandlpa1_on
32.14Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
32.00Single3PWHZM-2413853PWH-A2A-ZM-241385
32.00Single5WS3EMPA5WS3-OX2-EMPA
32.00Single7F8ULintitript7F8U-CCKA-Lintitript
32.00Single7F8YDevazepide7F8Y-CCKA-Devazepide
32.00Consensusorexin_offOrthosteric Ligandox2_off ox1_off
32.00Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
32.00Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
31.58Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
31.58Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
31.43Single4XT3Fractalkine4XT3-US28-Fractalkine
31.43Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
31.43Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
31.25Single3QAKUK-4320973QAK-A2A-UK-432097
31.25Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
31.25Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
31.25Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
31.25Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
31.25Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
31.25Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
31.25Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
31.25Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
31.25Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
31.25Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
31.25Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
31.25Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
31.25Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
31.25Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
31.03Single4RWADIPP-NH24RWA-δ-DIPP-NH2
31.03Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
31.03Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
31.03Single7YITNalfurafine7YIT-κ-Nalfurafine
31.03Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
31.03Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
31.03Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
31.03Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
31.03Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
31.03Single8XYIVUF106618XYI-CXCR3-VUF10661
31.03Single8ZPLHF511168ZPL-CXCR4-HF51116-Cholesterol
31.03Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
31.03Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
31.03Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
31.03Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
31.03Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
31.03Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
31.03Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
31.03Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
31.03Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
31.03Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
31.03Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
30.77Single4ZJCSB-6740424ZJC-OX1-SB-674042
30.77Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
30.77Single5IUBQ274563445IUB-A2A-Q27456344-Na
30.77Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
30.77Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
30.77Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
30.77Single7AROLUF58337ARO-A2A-LUF5833-Na
30.77Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
30.77Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
30.77Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
30.77Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
30.77Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
30.77Consensusgrh_offOrthosteric Ligandgnrh1_off
30.56Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
30.30Single3OE0CVX153OE0-CXCR4-CVX15
30.30Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
30.30Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
30.30Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
30.30Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
30.30Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
30.30Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
30.30Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
30.30Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
30.30Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
30.30Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
30.30Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
30.30Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
30.30Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
30.30Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
30.00Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
30.00Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
30.00Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
30.00Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
30.00Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
30.00Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
30.00Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
30.00Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
30.00Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
29.73Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
29.73Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
29.73Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
29.73Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
29.73Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
29.73Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
29.63Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
29.63Single5IU8Q274563475IU8-A2A-Q27456347-Na
29.63Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
29.63Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
29.63Single5UENDU1725UEN-A1-DU172
29.63Single5UIGCmpd-15UIG-A2A-Cmpd-1
29.63Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
29.63Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
29.63Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
29.63Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
29.63Single6TOTLemborexant6TOT-OX1-Lemborexant
29.63Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
29.63Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
29.63Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
29.63Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
29.63Single7PYRPSB-21157PYR-A2A-PSB-2115
29.63Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
29.63Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
29.63Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
29.63Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
29.63Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
29.63Single8CU6LJ-45178CU6-A2A-LJ-4517
29.63Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
29.63Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
29.63Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
29.63Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
29.63Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
29.63Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
29.63Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
29.63Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
29.41Single6JODAngiotensin II6JOD-AT2-Angiotensin II
29.41Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
29.41Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
29.41Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
29.41Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
29.41Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
29.41Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
29.41Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
29.41Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
29.41Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
29.41Consensusvasop-oxy_onOrthosteric Ligandv2_on
29.41Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
29.03Single4UG2CGS216804UG2-A2A-CGS21680
29.03Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
29.03Single5WF6UK-4320975WF6-A2A-UK-432097
29.03Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
29.03Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
29.03Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
29.03Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
29.03Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
29.03Single7XN9L-054,5227XN9-SST2-L-054,522
29.03Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
29.03Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
29.03Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
29.03Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
29.03Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
29.03Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
29.03Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
29.03Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
29.03Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
28.95Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
28.95Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
28.95Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
28.95Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
28.95Consensusbombesin_onOrthosteric Ligandbb2_on
28.95Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
28.95Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
28.57Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
28.57Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
28.57Single5C1MBU725C1M-μ-BU72
28.57Single5IUAQ274563485IUA-A2A-Q27456348-Na
28.57Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
28.57Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
28.57Single5WQCEMPA5WQC-OX2-EMPA
28.57Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
28.57Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
28.57Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
28.57Single6S0QZM-2413856S0Q-A2A-ZM-241385
28.57Single6TP6Filorexant6TP6-OX1-Filorexant
28.57Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
28.57Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
28.57Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
28.57Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
28.57Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
28.57Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
28.57Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
28.57Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
28.57Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
28.57Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
28.57Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
28.57Single8S4DCMF-0198S4D-Apelin-CMF-019
28.57Single8WGBW9R8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
28.57Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
28.57Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
28.57Single8XYKVUF106618XYK-CXCR3-VUF10661-Go1/β1/γ2
28.57Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
28.57Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
28.57Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
28.57Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
28.57Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
28.12Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
28.12Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
28.12Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
28.12Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
28.12Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
28.12Single8XWNCXCL88XWN-CXCR2-CXCL8
28.12Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
28.12Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
28.12Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
28.12Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
28.12Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
28.12Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
28.00Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
28.00Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
28.00Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
27.78Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
27.78Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
27.78Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
27.78Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
27.59Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
27.59Single4BV0Neurotensin4BV0-NTS1-Neurotensin
27.59Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
27.59Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
27.59Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
27.59Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
27.59Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
27.59Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
27.59Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
27.59Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
27.59Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
27.59Single7PX4PSB-21137PX4-A2A-PSB-2113
27.59Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
27.59Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
27.59Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
27.59Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
27.59Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
27.59Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
27.59Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
27.59Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
27.59Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
27.59Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
27.59Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
27.59Consensusa2_onOrthosteric Liganda2b_on
27.59Consensusa2_on_gpOrthosteric Liganda2b_on_gp
27.59Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
27.59Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
27.59Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
27.59Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
27.59Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
27.59Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
27.59Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
27.59Consensusneurotensin_onOrthosteric Ligandnts1_on
27.59Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
27.59Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
27.59Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
27.59Consensusrelaxin_onOrthosteric Ligandrxfp4_on
27.59Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
27.59Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
27.59Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
27.27Single6HLOAprepitant6HLO-NK1-Aprepitant
27.27Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
27.27Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
27.27Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
27.27Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
27.27Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
27.27Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
27.27Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
27.27Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
27.27Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
27.27Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
27.27Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
27.03Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
27.03Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
26.92Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
26.92Single4S0VSuvorexant4S0V-OX2-Suvorexant
26.92Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
26.92Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
26.92Single5ZKQABT-4915ZKQ-PAF-ABT-491
26.92Single6AKXA4R6AKX-CCR5-A4R
26.92Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
26.92Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
26.92Single6TODEMPA6TOD-OX1-EMPA-Na
26.92Single6TPJSuvorexant6TPJ-OX2-Suvorexant
26.92Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
26.92Single7BR3Elagolix7BR3-GnRH1-Elagolix
26.92Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
26.92Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
26.92Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
26.92Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
26.67Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
26.67Single4XEENeurotensin4XEE-NTS1-Neurotensin
26.67Single4XESNeurotensin4XES-NTS1-Neurotensin
26.67Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
26.67Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
26.67Single6MXTSalmeterol6MXT-β2-Salmeterol
26.67Single6OS2TRV0266OS2-AT1-TRV026
26.67Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
26.67Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
26.67Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
26.67Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
26.67Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
26.67Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
26.67Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
26.67Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
26.67Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
26.67Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
26.67Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
26.67Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
26.67Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
26.67Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
26.67Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
26.67Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
26.67Single8JJLOlodaterol8JJL-β2-Olodaterol
26.67Single8JWY2-1188JWY-A2A-2-118
26.67Single8JWZAB9288JWZ-A2A-AB928-Na
26.67Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
26.67Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
26.67Consensusalpha1_offOrthosteric Ligandalpha1a_off
26.67Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
26.67Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
26.67Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
26.67Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
26.67Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
26.67Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
26.67Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
26.67Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
26.67Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
26.67Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
26.47Single5WF5UK-4320975WF5-A2A-UK-432097
26.47Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
26.47Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
26.47Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
26.47Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
26.47Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
25.93Single3REYXAC3REY-A2A-XAC
25.93Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
25.93Single4MBSMaraviroc4MBS-CCR5-Maraviroc
25.93Single5IU7Q274563465IU7-A2A-Q27456346-Na
25.93Single5JTBZM-2413855JTB-A2A-ZM-241385
25.93Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
25.93Single6AQFZM-2413856AQF-A2A-ZM-241385
25.93Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
25.93Single6TP3Nemorexant6TP3-OX1-Nemorexant
25.93Single6TPGEMPA6TPG-OX2-EMPA
25.93Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
25.93Single6V9SGTPL114036V9S-OX1-GTPL11403
25.93Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
25.93Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
25.93Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
25.93Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
25.93Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
25.93Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
25.93Single8K5CAcipimox8K5C-HCA2-Acipimox
25.93Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
25.93Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
25.93Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
25.93Single8ZPMAMD0708ZPM-CXCR4-AMD070-Cholesterol
25.93Consensusa2_offOrthosteric Liganda2a_off
25.93Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
25.93Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
25.93Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
25.81Single4BUONeurotensin4BUO-NTS1-Neurotensin
25.81Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
25.81Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
25.81Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
25.81Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
25.81Single7EZCUKA7EZC-A2A-UKA
25.81Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
25.81Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
25.81Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
25.81Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.81Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
25.81Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
25.81Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
25.81Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
25.81Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.81Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
25.81Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
25.81Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(CtGi1-G13)/β1/γ2
25.81Consensusendothelin_offOrthosteric Ligandetb_off
25.81Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
25.81Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
25.81Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
25.81Consensusprostanoid_offOrthosteric Ligandep_off dp_off
25.71Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
25.71Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
25.71Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
25.71Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
25.71Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
25.00Single3EMLZM-2413853EML-A2A-ZM-241385
25.00Single3NY9ICI118-5513NY9-β2-ICI118-551
25.00Single4EJ4Naltrindole4EJ4-δ-Naltrindole
25.00Single4QIMANTA XV4QIM-SMO-ANTA XV
25.00Single4YAYZD-71554YAY-AT1-ZD-7155
25.00Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
25.00Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
25.00Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
25.00Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
25.00Single6D27CAY104716D27-DP2-CAY10471
25.00Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
25.00Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
25.00Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
25.00Single6PT3DPI-2876PT3-δ-DPI-287
25.00Single6S0LZM-2413856S0L-A2A-ZM-241385
25.00Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
25.00Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
25.00Single7SK9CCX6627SK9-ACKR3-CCX662
25.00Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
25.00Single7UL4Alvimopan7UL4-μ-Alvimopan
25.00Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
25.00Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
25.00Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
25.00Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
25.00Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
25.00Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
25.00Single7YXAONO-54306087YXA-S1P5-ONO-5430608
25.00Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
25.00Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
25.00Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
25.00Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
25.00Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
25.00Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
25.00Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
25.00Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
25.00Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
25.00Single8RLNLUF58348RLN-A2A-LUF5834
25.00Single8X5YAstemizole8X5Y-H1-Astemizole
25.00Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
25.00Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
25.00Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
25.00Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
25.00Consensusa3_onOrthosteric Liganda3a_on
25.00Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
25.00Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
25.00Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
25.00Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
25.00Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
25.00Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
25.00Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
25.00Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
25.00Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
24.32Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
24.24Single4IARErgotamine4IAR-5-HT1B-Ergotamine
24.24Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
24.24Single7QA8Peptide7QA8-STE2-Peptide
24.24Single7QA8Peptide7QA8-STE2-Peptide
24.24Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
24.24Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
24.24Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
24.24Single8WDTphotoNECA8WDT-A2A-photoNECA
24.24Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
24.24Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
24.24Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
24.24Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
24.24Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
24.24Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
24.24Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
24.24Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
24.14Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
24.14Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
24.14Single6D26Fevipiprant6D26-DP2-Fevipiprant
24.14Single6HLPNetupitant6HLP-NK1-Netupitant
24.14Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
24.14Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/β1/γ2
24.14Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
24.14Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
24.14Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
24.14Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
24.14Single7W41PD1762527W41-BB2-PD176252
24.14Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
24.14Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
24.14Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
24.14Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
24.14Single8JXSPF-61428JXS-D1-PF-6142
24.14Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
24.14Single8QOTNanobody-E8QOT-μ-Nanobody-E
24.14Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
24.14Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
24.14Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
24.14Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
24.14Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
24.14Consensusa3_on_gpOrthosteric Liganda3a_on_gp
24.14Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
24.14Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
24.14Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
24.14Consensusbombesin_offOrthosteric Ligandbb2_off
24.14Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
24.14Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
24.14Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
24.14Consensusdp_offOrthosteric Liganddp2_off
24.14Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
24.14Consensusep_offOrthosteric Ligandep4_off
24.14Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
24.14Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
24.14Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
24.00Single3OE6IT1t3OE6-CXCR4-IT1t
23.68Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
23.68Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
23.53Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
23.53Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
23.53Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
23.53Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
23.33Single3P0GBI1671073P0G-β2-BI167107
23.33Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
23.33Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
23.33Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
23.33Single5V56TC1145V56-SMO-TC114
23.33Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
23.33Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
23.33Single6OS1TRV0266OS1-AT1-TRV026
23.33Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
23.33Single6TQ7SB-3348676TQ7-OX1-SB-334867
23.33Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
23.33Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
23.33Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
23.33Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
23.33Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
23.33Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
23.33Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
23.33Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
23.33Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
23.33Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
23.33Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
23.33Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
23.33Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
23.33Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
23.33Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
23.33Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
23.33Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
23.33Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
23.33Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
23.33Single8XVLZibotentan8XVL-ETA-Zibotentan
23.33Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
23.33Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
23.33Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
23.33Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
23.33Single9BJKNAM9BJK-μ-Naloxone-NAM
23.33Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
23.33Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
23.33Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
23.33Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
23.33Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
23.33Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
23.33Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
23.33Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
23.33Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
23.08Single3OE9IT1t3OE9-CXCR4-IT1t
23.08Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
23.08Single6HLLCP999946HLL-NK1-CP99994
23.08Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
23.08Single6TP4ACT-4622066TP4-OX1-ACT-462206
23.08Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
23.08Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
23.08Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
23.08Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
23.08Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
23.08Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
23.08Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
23.08Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
23.08Single8YRGFospropofol8YRG-MRGPRX4-Fospropofol-chim(NtGi1-Gs-CtGq)/β1/γ2
23.08Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
23.08Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
22.86Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
22.86Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
22.86Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
22.86Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
22.58Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
22.58Single4LDEBI1671074LDE-β2-BI167107
22.58Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
22.58Single4PY02MeSATP4PY0-P2Y12-2MeSATP
22.58Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
22.58Single5TZYMK8666; PubChem 1270535975TZY-FFA1-MK8666; PubChem 127053597
22.58Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
22.58Single6YVRNTS8-136YVR-NTS1-NTS8-13
22.58Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
22.58Single7K15MKD0467K15-BLT1-MKD046-Na
22.58Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
22.58Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
22.58Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
22.58Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
22.58Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
22.58Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
22.58Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.58Single8JJ8Formoterol8JJ8-β2-Formoterol
22.58Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
22.58Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
22.58Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
22.58Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
22.58Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
22.50Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
22.22Single3ODUIT1t3ODU-CXCR4-IT1t
22.22Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
22.22Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
22.22Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
22.22Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
22.22Single6AKYMaraviroc6AKY-CCR5-Maraviroc
22.22Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
22.22Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
22.22Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
22.22Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
22.22Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.22Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
22.22Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
22.22Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
22.22Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
22.22Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
22.22Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
22.22Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
22.22Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.22Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
22.22Single8GNGIstradefylline8GNG-A2A-Istradefylline
22.22Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
22.22Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
22.22Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
22.22Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
22.22Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
22.22Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.22Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/β1/γ2
22.22Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
22.22Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
22.22Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
22.22Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
22.22Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
22.22Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
22.22Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
22.22Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
22.22Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
22.22Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
22.22Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
22.22Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
21.88Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
21.88Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
21.88Single5X93K-87945X93-ETB-K-8794
21.88Single6H7LDobutamine6H7L-β1-Dobutamine
21.88Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
21.88Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
21.88Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
21.88Single7UM4AS26747237UM4-5-HT5A-AS2674723
21.88Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
21.88Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-PubChem 118610427-chim(NtGi1-Go)/β1/γ2
21.88Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
21.88Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
21.88Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
21.88Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
21.88Single8XVUCXCL28XVU-CXCR2-CXCL2
21.88Single8XWFCXCL38XWF-CXCR2-CXCL3
21.88Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
21.88Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
21.88Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
21.88Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
21.88Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.88Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.62Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
21.62Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
21.62Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
21.62Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
21.62Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
21.62Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
21.62Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
21.62Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
21.43Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
21.43Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
21.43Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
21.43Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
21.43Single5UVIZM-2413855UVI-A2A-ZM-241385
21.43Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
21.43Single6IQLL7458706IQL-D4-L745870
21.43Single6MH8ZM-2413856MH8-A2A-ZM-241385
21.43Single6TPKRetosiban6TPK-OT-Retosiban
21.43Single6TPNHTL66416TPN-OX2-HTL6641
21.43Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
21.43Single7T32ZM-2413857T32-A2A-ZM-241385
21.43Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
21.43Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
21.43Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
21.43Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
21.43Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
21.43Single8IHKAcifran8IHK-HCA3-Acifran
21.43Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
21.43Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
21.43Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
21.43Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
21.43Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
21.43Single8K2WAMG4878K2W-CXCR3-AMG487
21.43Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
21.43Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
21.43Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
21.43Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
21.43Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
21.43Single8ZPNAMD31008ZPN-CXCR4-AMD3100-Cholesterol
21.43Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
21.43Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
21.43Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
21.43Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
21.43Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
21.43Consensushca_onOrthosteric Ligandhca2_on
21.43Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
21.43Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
21.43Consensusvasop-oxy_offOrthosteric Ligandot_off
21.21Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
21.21Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
21.21Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
21.21Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
21.21Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
21.21Single8XQJJN2418XQJ-Apelin-JN241
21.21Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
21.05Single6FJ3PTH6FJ3-PTH1-PTH
21.05Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
21.05Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
21.05Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
21.05Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
20.93Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
20.69Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
20.69Single5T04Neurotensin5T04-NTS1-Neurotensin
20.69Single5TGZAM65385TGZ-CB1-AM6538
20.69Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
20.69Single7BU7BI1671077BU7-β1-BI167107
20.69Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
20.69Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
20.69Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
20.69Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
20.69Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
20.69Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
20.69Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
20.69Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
20.69Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
20.69Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
20.69Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
20.69Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
20.69Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
20.69Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
20.69Single8K5DGSK2560738K5D-HCA2-GSK256073
20.69Single8PJKST1718PJK-5-HT1A-ST171-t7m-Gi1/β1/γ1
20.69Single8T1WCVN4248T1W-GPR6-CVN424
20.69Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.69Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.69Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.69Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.69Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.69Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
20.69Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
20.69Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
20.69Single9B9ZA1AKO9B9Z-CB1-A1AKO
20.69Single9CHXS-Carazolol9CHX-β2-S-Carazolol
20.69Single9IMATalquetamab9IMA-GPRC5D-Talquetamab
20.69Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
20.69Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
20.69Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
20.69Consensusblt_onOrthosteric Ligandblt1_on
20.69Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
20.69Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
20.69Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
20.69Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
20.69Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
20.69Consensushca_on_gpOrthosteric Ligandhca2_on_gp
20.69Consensusleukotriene_onOrthosteric Ligandblt_on
20.69Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
20.69Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
20.59Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
20.59Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
20.59Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
20.59Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
20.59Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
20.59Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
20.59Single8PKMBefiradol8PKM-5-HT1A-Befiradol-t7m-Gi1/β1/γ1
20.59Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
20.59Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
20.59Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
20.59Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
20.51Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
20.51Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
20.51Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
20.51Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
20.51Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
20.00Single2Y00Dobutamine2Y00-β1-Dobutamine
20.00Single3OE8IT1t3OE8-CXCR4-IT1t
20.00Single3RFMCaffeine3RFM-A2A-Caffeine
20.00Single4JKVTaladegib4JKV-SMO-Taladegib
20.00Single4NTJAZD12834NTJ-P2Y12-AZD1283
20.00Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
20.00Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
20.00Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
20.00Single5X7DS-Carazolol5X7D-β2-S-Carazolol-PubChem 129318963
20.00Single5XPRBosentan5XPR-ETB-Bosentan
20.00Single6E67BI1671076E67-β2-BI167107-Gs (fused)
20.00Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
20.00Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
20.00Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
20.00Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
20.00Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
20.00Single6TQ9SB-4081246TQ9-OX1-SB-408124
20.00Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
20.00Single7C4SS1P7C4S-S1P3-S1P
20.00Single7C61Ergotamine7C61-5-HT1B-Ergotamine
20.00Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
20.00Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
20.00Single7SINNPS-21437SIN-CaS-NPS-2143
20.00Single7SINNPS-21437SIN-CaS-NPS-2143
20.00Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
20.00Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
20.00Single7WC6LSD7WC6-5-HT2A-LSD
20.00Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
20.00Single7XNACYN1548067XNA-SST2-CYN154806
20.00Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Single8A2OTheophylline8A2O-A2A-Theophylline-Na
20.00Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
20.00Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
20.00Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
20.00Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
20.00Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
20.00Single8IEBA1LYA8IEB-GPR156-A1LYA
20.00Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
20.00Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
20.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
20.00Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
20.00Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
20.00Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
20.00Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
20.00Consensusblt_offOrthosteric Ligandblt1_off
20.00Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
20.00Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
20.00Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
20.00Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
19.57Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
19.44Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
19.44Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
19.35Single2YDVNECA2YDV-A2A-NECA
19.35Single4DJHJDTic4DJH-κ-JDTic
19.35Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
19.35Single4UHRCGS216804UHR-A2A-CGS21680
19.35Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
19.35Single5G53NECA5G53-A2A-NECA-Gs
19.35Single5TZRMK86665TZR-FFA1-MK8666
19.35Single5V57TC1145V57-SMO-TC114
19.35Single6E59L-7607356E59-NK1-L-760735
19.35Single6H7JIsoprenaline6H7J-β1-Isoprenaline
19.35Single6J20Aprepitant6J20-NK1-Aprepitant
19.35Single6J21Aprepitant6J21-NK1-Aprepitant
19.35Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
19.35Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
19.35Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
19.35Single7R0CAVP7R0C-V2-AVP-Arrestin2
19.35Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
19.35Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
19.35Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
19.35Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
19.35Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
19.35Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
19.35Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
19.35Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
19.35Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
19.35Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
19.35Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
19.35Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
19.35Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
19.35Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
19.35Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
19.35Single9GE2ML1849GE2-GPR55-ML184-Cholesterol-chim(CtGi1-G13)/β1/γ2
19.35Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
19.35Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
19.35Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
19.35Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
19.35Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
19.35Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
19.35Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
19.35Consensustachykinin_offOrthosteric Ligandnk1_off
19.23Single4XNWMRS25004XNW-P2Y1-MRS2500
19.23Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
19.23Single7V6A-7V6A-M4-PubChem 9864275-Gi1/β1/γ2
19.23Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
19.23Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
19.23Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
19.23Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
19.23Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
19.23Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
19.23Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
19.23Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
19.05Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
19.05Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
19.05Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
18.92Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
18.92Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
18.92Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
18.92Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
18.92Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
18.92Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
18.75Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
18.75Single5X33BIIL2605X33-BLT1-BIIL260
18.75Single6A93Risperidone6A93-5-HT2A-Risperidone
18.75Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
18.75Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
18.75Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
18.75Single6ZG4HTL00099366ZG4-M1-HTL0009936
18.75Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
18.75Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
18.75Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
18.75Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
18.75Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
18.75Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
18.75Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
18.75Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
18.75Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
18.75Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
18.75Single8XWACXCL18XWA-CXCR2-CXCL1
18.75Single8XWMCXCL68XWM-CXCR2-CXCL6
18.75Single8XWSCXCL58XWS-CXCR2-CXCL5
18.75Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
18.75Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
18.75Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
18.75Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
18.75Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
18.75Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
18.75Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
18.75Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
18.75Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
18.75Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
18.75Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
18.75Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
18.75Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
18.75Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
18.60Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
18.52Single4O9RCyclopamine4O9R-SMO-Cyclopamine
18.52Single5L7IVismodegib5L7I-SMO-Vismodegib
18.52Single6LI0C176LI0-GPR52-C17
18.52Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
18.52Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
18.52Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
18.52Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
18.52Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
18.52Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
18.52Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
18.52Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
18.52Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
18.52Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
18.52Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
18.52Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
18.52Single8K5BNiacin8K5B-HCA2-Niacin
18.52Single9B9Y7DY9B9Y-CB1-7DY
18.52Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
18.52Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
18.42Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
18.18Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
18.18Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
18.18Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
18.18Single6IBLArformoterol6IBL-β1-Arformoterol
18.18Single6K1QIRL25006K1Q-ETB-IRL2500
18.18Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
18.18Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
18.18Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
18.18Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
18.18Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
18.18Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
18.18Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
18.18Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.18Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
18.18Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
18.18Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
18.18Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
18.18Consensuschemerin_onOrthosteric Ligandcml1_on
18.18Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
18.18Consensusfp-alpha_onOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
17.95Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
17.95Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
17.95Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
17.95Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
17.86Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
17.86Single4BWBNeurotensin4BWB-NTS1-Neurotensin
17.86Single4QINSAG1.54QIN-SMO-SAG1.5
17.86Single5U09Taranabant5U09-CB1-Taranabant
17.86Single6B73MP11046B73-κ-MP1104
17.86Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
17.86Single6DS0Ly2660976DS0-5-HT2B-Ly266097
17.86Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
17.86Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
17.86Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
17.86Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
17.86Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
17.86Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
17.86Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
17.86Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
17.86Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
17.86Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
17.86Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
17.86Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
17.86Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
17.86Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.86Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
17.86Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
17.86Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
17.86Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
17.86Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
17.86Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
17.86Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
17.86Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
17.86Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
17.86Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
17.86Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
17.86Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
17.86Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
17.86Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
17.86Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
17.86Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
17.86Single8Y0HVUF114188Y0H-CXCR3-VUF11418
17.86Single9BA0A1AKN9BA0-CB1-A1AKN
17.86Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
17.86Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
17.86Consensusangiotensin_offOrthosteric Ligandat1_off
17.86Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
17.65Single5EE7MK08935EE7-Glucagon-MK0893
17.65Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
17.65Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
17.65Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
17.65Single8IEIA1LYA8IEI-GPR156-A1LYA
17.65Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
17.65Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
17.65Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
17.65Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
17.65Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
17.65Consensuskisspeptin_onOrthosteric Ligandkiss1_on
17.50Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
17.50Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
17.50Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
17.24Single2YDOAdenosine2YDO-A2A-Adenosine
17.24Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
17.24Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
17.24Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
17.24Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
17.24Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
17.24Single6PS0S-Carazolol6PS0-β2-S-Carazolol
17.24Single6PS4ICI118-5516PS4-β2-ICI118-551
17.24Single6PS5S-Propranolol6PS5-β2-S-Propranolol
17.24Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
17.24Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
17.24Single6ZG9GSK10347026ZG9-M1-GSK1034702
17.24Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
17.24Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
17.24Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
17.24Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
17.24Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
17.24Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
17.24Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
17.24Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
17.24Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.24Single7VV6C48/807VV6-MRGPRX2-C48/80
17.24Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
17.24Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
17.24Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
17.24Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
17.24Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
17.24Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
17.24Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
17.24Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
17.24Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
17.24Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
17.24Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
17.24Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
17.24Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
17.24Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
17.24Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ2
17.24Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
17.24Single8K9LDamgo8K9L-μ-Damgo-VV9-Gi3/β1/γ1
17.24Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.24Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
17.24Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
17.24Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
17.24Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
17.24Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
17.24Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
17.24Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.24Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
17.24Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
17.24Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
17.24Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Cholesterol-Gi1/β1/γ2
17.24Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
17.24Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
17.24Consensusalpha1_onOrthosteric Ligandalpha1a_on
17.24Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
17.24Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
17.24Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
17.24Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
17.24Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
17.24Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
17.24Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
17.14Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
17.14Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
17.14Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
17.14Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
17.14Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
17.14Single8IEBA1LYA8IEB-GPR156-A1LYA
17.14Single8IEPA1LYA8IEP-GPR156-A1LYA
17.14Single8IEPA1LYA8IEP-GPR156-A1LYA
17.14Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
17.14Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
17.14Consensussomatostatin_offOrthosteric Ligandsst2_off
17.07Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
17.07Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
17.07Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
17.07Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
17.07Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
16.67Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
16.67Single2Y01Dobutamine2Y01-β1-Dobutamine
16.67Single2Y02Carmoterol2Y02-β1-Carmoterol
16.67Single2Y04Salbutamol2Y04-β1-Salbutamol
16.67Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
16.67Single3NY8ICI118-5513NY8-β2-ICI118-551
16.67Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
16.67Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
16.67Single4GBRS-Carazolol4GBR-β2-S-Carazolol
16.67Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
16.67Single4QKX35V4QKX-β2-35V
16.67Single5DHGC-355DHG-NOP-C-35
16.67Single5DHHSB-6121115DHH-NOP-SB-612111
16.67Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
16.67Single6GPSMK08126GPS-CCR2-MK0812
16.67Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/β1/γ2
16.67Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
16.67Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
16.67Single6PS1Timolol6PS1-β2-Timolol
16.67Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
16.67Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
16.67Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
16.67Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
16.67Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
16.67Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
16.67Single7F83PF-051904577F83-Ghrelin-PF-05190457
16.67Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
16.67Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
16.67Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
16.67Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/β1/γ2
16.67Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
16.67Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
16.67Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
16.67Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
16.67Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
16.67Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
16.67Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
16.67Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
16.67Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
16.67Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
16.67Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
16.67Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
16.67Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
16.67Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
16.67Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
16.67Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.67Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.67Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.67Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.67Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.67Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.67Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.67Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.67Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.67Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.67Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
16.67Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
16.67Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
16.67Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
16.67Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
16.67Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
16.67Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
16.67Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
16.67Single8JXRLSD8JXR-D1-LSD
16.67Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
16.67Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
16.67Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
16.67Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
16.67Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.67Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.67Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
16.67Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
16.67Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
16.67Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
16.67Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
16.67Single9IVGGLP-1 (Truncated)9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
16.67Single9IYAONO-97105319IYA-GPR55-ONO-9710531
16.67Consensus5ht5_onOrthosteric Ligand5ht5a_on
16.67Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
16.67Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
16.67Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
16.67Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
16.67Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
16.67Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
16.67Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
16.67Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
16.67Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
16.67Consensusdopamine_offOrthosteric Ligandd2_off d3_off
16.67Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
16.67Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
16.67Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
16.28Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
16.22Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
16.13Single2RH1S-Carazolol2RH1-β2-S-Carazolol
16.13Single2Y03Isoprenaline2Y03-β1-Isoprenaline
16.13Single2YCWS-Carazolol2YCW-β1-S-Carazolol
16.13Single5D6LS-Carazolol5D6L-β2-S-Carazolol
16.13Single5JQHS-Carazolol5JQH-β2-S-Carazolol
16.13Single5TVNLSD5TVN-5-HT2B-LSD
16.13Single5WIUNemonapride5WIU-D4-Nemonapride
16.13Single5WIVNemonapride5WIV-D4-Nemonapride-Na
16.13Single6GPXMK08126GPX-CCR2-MK0812
16.13Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
16.13Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
16.13Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
16.13Single6Z4SSR486926Z4S-NTS1-SR48692
16.13Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
16.13Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
16.13Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
16.13Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
16.13Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
16.13Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
16.13Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
16.13Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
16.13Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
16.13Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.13Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.13Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
16.13Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
16.13Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
16.13Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
16.13Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
16.13Single9F34FOB02-04A9F34-D3-FOB02-04A-Go1/β1/γ2
16.13Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
16.13Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
16.13Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
16.13Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
16.13Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
16.13Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
16.13Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
16.13Consensusamine_offonOrthosteric Ligandamine_off amine_on
16.13Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
16.13Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
16.13Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
16.13Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
16.13Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
16.13Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
16.13Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
16.13Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
16.13Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
16.13Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
16.13Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
16.13Consensustrace-amine_onOrthosteric Ligandta1_on
16.00Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
16.00Single8PWNTheophylline8PWN-A2A-Theophylline
15.91Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
15.91Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
15.91Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
15.79Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
15.79Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
15.79Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
15.79Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ22
15.79Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
15.62Single5D5AS-Carazolol5D5A-β2-S-Carazolol
15.62Single5D5BS-Carazolol5D5B-β2-S-Carazolol
15.62Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
15.62Single6WGTLSD6WGT-5-HT2A-LSD
15.62Single7B6WCyclazosin7B6W-α1b-Cyclazosin
15.62Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
15.62Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
15.62Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
15.62Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
15.62Single8GDBPGE28GDB-EP4-PGE2-Gs/β1/γ2
15.62Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
15.62Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
15.62Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
15.62Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
15.62Single8YNTSNAP-948478YNT-MCH1-SNAP-94847
15.62Single9F33FOB02-04A9F33-D3-FOB02-04A-Go1/β1/γ2
15.62Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
15.62Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
15.62Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
15.62Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
15.62Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
15.62Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.62Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
15.56Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
15.38Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
15.38Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
15.38Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
15.38Consensusp2y_offOrthosteric Ligandp2y1_off
15.22Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
15.15Single3D4STimolol3D4S-β2-Timolol
15.15Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
15.15Single4AMIBucindolol4AMI-β1-Bucindolol
15.15Single4N4WSANT-14N4W-SMO-SANT-1
15.15Single6CM4Risperidone6CM4-D2-Risperidone
15.15Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
15.15Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
15.15Single6IIURamatroban6IIU-TP-Ramatroban
15.15Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
15.15Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
15.15Single7DFPSpiperone7DFP-D2-Spiperone
15.15Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
15.15Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
15.15Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
15.15Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
15.15Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
15.15Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
15.15Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
15.15Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
15.15Single8XJNCloprosetnol8XJN-TP-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
15.15Single8XQJJN2418XQJ-Apelin-JN241
15.15Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
15.15Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
15.15Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
15.15Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
15.00Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
15.00Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
14.81Single3UZAGTPL92363UZA-A2A-GTPL9236
14.81Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
14.81Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
14.81Single6ME5Agomelatine6ME5-MT1-Agomelatine
14.81Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
14.81Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
14.81Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
14.81Single7WC5Psilocin7WC5-5-HT2A-Psilocin
14.81Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.81Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.81Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
14.81Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
14.81Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
14.81Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
14.81Consensus5ht2_onOrthosteric Ligand5ht2b_on
14.81Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.71Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
14.71Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
14.71Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
14.71Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
14.71Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
14.71Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
14.71Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
14.71Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
14.71Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
14.71Consensustp_onOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
14.71Consensustp_on_gpOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
14.63Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
14.63Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
14.63Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
14.63Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
14.63Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
14.63Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
14.63Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
14.63Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
14.29Single3PBLEticlopride3PBL-D3-Eticlopride
14.29Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
14.29Single6KNMJN241-96KNM-Apelin-JN241-9
14.29Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
14.29Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
14.29Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
14.29Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
14.29Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
14.29Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
14.29Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
14.29Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
14.29Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
14.29Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29Single7SRQLSD7SRQ-5-HT2B-LSD
14.29Single7UL2SR486927UL2-NTS1-SR48692-Na
14.29Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
14.29Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
14.29Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
14.29Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
14.29Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
14.29Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
14.29Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
14.29Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
14.29Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
14.29Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go1/β1/γ2
14.29Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
14.29Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
14.29Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
14.29Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
14.29Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
14.29Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
14.29Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
14.29Consensusgq_nucleotideOrthosteric Ligandgq_p2y
14.29Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
14.29Consensusneurotensin_offOrthosteric Ligandnts1_off
14.29Consensusnts1_offOrthosteric Ligand7UL2-NTS1-SR48692-Na
13.89Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
13.89Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
13.89Single8IEIA1LYA8IEI-GPR156-A1LYA
13.89Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
13.79Single6ME2Ramelteon6ME2-MT1-Ramelteon
13.79Single6ME9Ramelteon6ME9-MT2-Ramelteon
13.79Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
13.79Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
13.79Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
13.79Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
13.79Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
13.79Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
13.79Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
13.79Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
13.79Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
13.79Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
13.79Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.79Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
13.79Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
13.79Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
13.79Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
13.79Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
13.79Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
13.79Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.79Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
13.79Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
13.79Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
13.79Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
13.79Single8IWESpermidine8IWE-TA9-Spermidine
13.79Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
13.79Single8T3VDocosa-4,7,10,13,16,19-Hexaenoic acid8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.79Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
13.79Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
13.79Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
13.79Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
13.79Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
13.79Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
13.79Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
13.79Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
13.79Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.79Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
13.79Consensusalpha2_offOrthosteric Ligandalpha2c_off
13.79Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
13.79Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
13.79Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
13.79Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
13.64Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
13.64Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
13.51Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
13.33Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
13.33Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
13.33Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
13.33Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
13.33Single6KUXRS-799486KUX-α2a-RS-79948
13.33Single6VI4JDTic6VI4-κ-JDTic
13.33Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
13.33Single6ZINSR486926ZIN-NTS1-SR48692
13.33Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
13.33Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
13.33Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
13.33Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
13.33Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
13.33Single7UL3Famotidine7UL3-H2-Famotidine
13.33Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
13.33Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
13.33Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
13.33Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
13.33Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
13.33Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
13.33Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
13.33Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
13.33Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
13.33Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.33Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
13.33Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
13.33Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
13.33Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.33Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
13.33Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
13.33Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
13.33Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
13.33Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
13.33Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
13.33Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
13.33Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
13.33Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
13.33Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
13.33Single9BJKNaloxone9BJK-μ-Naloxone-NAM
13.33Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
13.33Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
13.33Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
13.04Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
12.90Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
12.90Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
12.90Single6DRXLisuride6DRX-5-HT2B-Lisuride
12.90Single6H7MSalbutamol6H7M-β1-Salbutamol
12.90Single6IIVDaltroban6IIV-TP-Daltroban
12.90Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
12.90Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.90Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
12.90Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
12.90Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
12.90Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
12.90Single7WC7Lisuride7WC7-5-HT2A-Lisuride
12.90Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
12.90Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
12.90Single8JJOAlprenolol8JJO-β2-Alprenolol
12.90Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
12.90Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
12.90Single8TH3AT118-H Nanobody8TH3-AT1-AT118-H Nanobody
12.90Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
12.90Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
12.90Single8X63Mepyramine8X63-H1-Mepyramine
12.90Single8X64Desloratadine8X64-H1-Desloratadine
12.90Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
12.90Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
12.90Consensusalpha2_onOrthosteric Ligandalpha2b_on
12.90Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
12.90Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
12.90Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
12.90Consensushistamine_offOrthosteric Ligandh1_off
12.82Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
12.82Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
12.82Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
12.50Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
12.50Single6LUQHaloperidol6LUQ-D2-Haloperidol
12.50Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
12.50Single6PS6Timolol6PS6-β2-Timolol
12.50Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
12.50Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
12.50Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
12.50Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
12.50Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
12.50Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
12.50Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
12.50Single8ZMFA1L108ZMF-5-HT2C-A1L10
12.50Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
12.50Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
12.50Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
12.50Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
12.20Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
12.20Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
12.20Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
12.12Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
12.12Single4U15Tiotropium4U15-M3-Tiotropium
12.12Single5V54Methiothepin5V54-5-HT1B-Methiothepin
12.12Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
12.12Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
12.12Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
12.12Single6OL9Tiotropium6OL9-M5-Tiotropium
12.12Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
12.12Single7F1TMIP-1a7F1T-CCR5-MIP-1a
12.12Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
12.12Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
12.12Consensus5ht1_offOrthosteric Ligand5ht1b_off
12.12Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
12.12Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
12.12Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
12.12Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
12.12Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
12.12Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
12.00Single5MZPCaffeine5MZP-A2A-Caffeine-Na
12.00Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
12.00Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
12.00Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
12.00Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
11.76Single5CXVTiotropium5CXV-M1-Tiotropium
11.76Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
11.76Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
11.76Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
11.76Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
11.76Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.76Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
11.76Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
11.76Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
11.76Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
11.76Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
11.63Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
11.54Single3PXOAll-trans-Retinal3PXO-Rhodopsin-All-trans-Retinal
11.54Single5DYSAll-trans-Retinal5DYS-Rhodopsin-All-trans-Retinal
11.54Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
11.54Single7XKDBeta-Hydroxyandrosterone7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
11.54Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
11.43Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
11.43Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
11.43Single8XVJMacitentan8XVJ-ETA-Macitentan
11.43Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
11.36Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
11.11Single6OY9All-trans-Retinal6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
11.11Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
11.11Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
11.11Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.11Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
11.11Single8IWM2-Phenylethylamine8IWM-TA9-2-Phenylethylamine
11.11Single8WC5Tetramethylammonium Ion8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
11.11Single9AUCCalcitonin gene-related peptide-19AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
11.11Single9CHUNoradrenaline9CHU-β2-Noradrenaline
11.11Consensusgs_histamineOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
11.11Consensush2_onOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
11.11Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
11.11Consensussensory_onOrthosteric Ligandopsins_on
10.71Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
10.71Single3PQRAll-trans-Retinal3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
10.71Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
10.71Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
10.71Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
10.71Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
10.71Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
10.71Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
10.71Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
10.71Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
10.71Single8IW72-Phenylethylamine8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
10.71Single8JPSCCL78JPS-ACKR1-CCL7
10.71Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
10.71Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
10.71Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
10.71Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
10.71Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
10.71Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
10.71Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
10.71Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
10.71Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
10.71Consensusgi_sensoryOrthosteric Ligandgi_opsins
10.71Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
10.71Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
10.71Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
10.71Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
10.71Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
10.71Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
10.71Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
10.71Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
10.64Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
10.64Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
10.34Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
10.34Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
10.34Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
10.34Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
10.34Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.34Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
10.34Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
10.34Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
10.34Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
10.34Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
10.34Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
10.34Single8YN7Immethridine8YN7-H3-Immethridine-Go1/β1/γ2
10.34Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
10.34Single9EPRRetinal9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
10.00Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
10.00Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
10.00Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
10.00Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
10.00Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
10.00Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
10.00Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
10.00Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
10.00Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
10.00Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
10.00Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
10.00Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
10.00Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
10.00Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ
10.00Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
10.00Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
10.00Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
10.00Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
10.00Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
10.00Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
10.00Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
10.00Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
10.00Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
9.76Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
9.76Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
9.68Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
9.68Single3RZECidoxepin3RZE-H1-Cidoxepin
9.68Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
9.68Single6A94Zotepine6A94-5-HT2A-Zotepine
9.68Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
9.68Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
9.68Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
9.68Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
9.68Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
9.68Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
9.68Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.68Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
9.68Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
9.68Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
9.68Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
9.68Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
9.68Single8YN8Proxyfan8YN8-H3-Proxyfan-Go1/β1/γ2
9.68Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
9.68Consensusopsins_offOrthosteric Ligandrhodopsin_off
9.68Consensussensory_offOrthosteric Ligandopsins_off
9.38Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
9.38Single4DAJTiotropium4DAJ-M3-Tiotropium
9.38Single4MQSIperoxo4MQS-M2-Iperoxo
9.38Single4U14Tiotropium4U14-M3-Tiotropium
9.38Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
9.38Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
9.38Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
9.38Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
9.38Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
9.38Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
9.38Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
9.38Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
9.38Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
9.38Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
9.38Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
9.38Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
9.38Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
9.38Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
9.30Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
9.09Single5CGCHTL142425CGC-mGlu5-HTL14242
9.09Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
9.09Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
9.09Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
9.09Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.09Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
9.09Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
9.09Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
9.09Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
9.09Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
9.09Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
9.09Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
9.09Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
9.09Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
9.09Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.09Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.82Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
8.82Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
8.82Single8EA0Iperoxo8EA0-M3-Iperoxo
8.82Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
8.82Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
8.82Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Cholesterol-Gi1/β1/γ1
8.82Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
8.82Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
8.33Single5CGDHTL142425CGD-mGlu5-HTL14242
8.00Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
8.00Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
7.69Single4A4MAll-trans-Retinal4A4M-Rhodopsin-All-trans-Retinal-Gt(CT)
7.69Single5EN0All-trans-Retinal5EN0-Rhodopsin-All-trans-Retinal-Gt(CT)
7.69Single8GEJConstrained Epinephrine8GEJ-β2-Constrained Epinephrine-Gs/β1/γ2
7.41Single7WC4Serotonin7WC4-5-HT2A-Serotonin
7.41Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
7.41Single8X9S5alpha-DHT8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
7.41Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
7.14Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
7.14Single7Y14Beta-Alanine7Y14-MRGPRD-β-Alanine
7.14Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/β1/γ2
6.90Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
6.90Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
6.90Single7Y12Beta-Alanine7Y12-MRGPRD-β-Alanine-Gi1/β1/γ2
6.90Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.90Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
6.90Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
6.90Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
6.67Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
6.67Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
6.67Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
6.67Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
6.67Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
6.67Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
6.67Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
6.67Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
6.67Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
6.67Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
6.67Single8HSCFab0468HSC-GPR20-Fab046-Gi1/β1/γ2
6.67Single8YN2Histamine8YN2-H1-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
6.67Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
6.67Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
6.45Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
6.45Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
6.45Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
6.45Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
6.45Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
6.45Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
6.25Single7VODCariprazine7VOD-5-HT2A-Cariprazine
6.25Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
6.06Single5DSGTiotropium5DSG-M4-Tiotropium
6.06Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
5.88Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
5.88Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.88Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
5.88Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
5.71Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
5.71Single7P2L4YI7P2L-mGlu5-4YI
5.71Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
4.17Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
4.17Single6D35Cholesterol6D35-SMO-Cholesterol
4.17Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
4.17Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
4.17Single6UO8SKF975416UO8-GABAB1, GABAB2-SKF97541-GS39783
4.17Single6UO9SKF975416UO9-GABAB1, GABAB2-SKF97541
4.17Single6W2XPubChem 53110426W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
4.17Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
4.17Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
4.17Single7C7QBaclofen7C7Q-GABAB1, GABAB2-Baclofen-PubChem 7023848
4.17Single7C7SCGP546267C7S-GABAB1, GABAB2-CGP54626
4.17Single7CUMCGP546267CUM-GABAB1, GABAB2-CGP54626-Phospholipid
4.17Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
4.17Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
4.17Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
4.17Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
4.17Single7DGEQuisqualate7DGE-mGlu1; mGlu1-Quisqualate
4.17Single7DTTCa7DTT-CaS-Ca-Ca
4.17Single7DTTCa7DTT-CaS-Ca-Ca
4.17Single7DTUTryptophan7DTU-CaS-Tryptophan
4.17Single7DTUTryptophan7DTU-CaS-Tryptophan
4.17Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
4.17Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
4.17Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
4.17Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
4.17Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.17Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.17Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.17Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.17Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
4.17Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
4.17Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
4.17Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
4.17Single7EB2Baclofen7EB2-GABAB2; GABAB1-Baclofen-rac-BHFF-Gi1/β1/γ2
4.17Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
4.17Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
4.17Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
4.17Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
4.17Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
4.17Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
4.17Single7FIHhCG7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
4.17Single7FIIhCG7FII-LH-hCG-chim(NtGi1-Gs)/β1/γ2
4.17Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
4.17Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
4.17Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
4.17Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
4.17Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.17Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.17Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.17Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.17Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
4.17Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
4.17Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
4.17Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
4.17Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
4.17Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
4.17Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
4.17Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
4.17Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
4.17Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
4.17Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.17Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.17Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.17Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.17Single7T9NM22 Fab7T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
4.17Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
4.17Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
4.17Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
4.17Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
4.17Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
4.17Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
4.17Single7XW6M22 Fab7XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
4.17Single7XW7K1-707XW7-TSH-K1-70
4.17Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
4.17Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
4.17Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
4.17Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
4.17Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
4.17Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
4.17Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
4.17Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
4.17Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
4.17Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
4.17Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
4.17Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
4.17Single8JD0Glutamate8JD0-mGlu2; mGlu3-Glutamate-NAM563
4.17Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
4.17Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
4.17Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
4.17Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
4.17Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
4.17Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
4.17Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
4.17Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
4.17Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
4.17Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
4.17Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
4.17Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
4.17Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
4.17Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
4.17Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
4.17Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
4.17Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
4.17Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
4.17Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
4.17Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
4.17Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
4.17Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
4.17Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
4.17Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
4.17Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
4.17Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
4.17Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
4.17Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
4.17Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
4.17Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
4.17Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
4.17Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
4.17Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
4.17Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
4.17Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
4.17Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
4.17Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
4.17Single8WG9(2S)-2-amino-4-phosphonobutanoic acid8WG9-mGlu4; mGlu2-(2S)-2-amino-4-phosphonobutanoic acid
4.17Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
4.17Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
4.17Single8WGCLY3792688WGC-mGlu4; mGlu2-LY379268
4.17Single8WGDWAG/WA68WGD-mGlu4; mGlu2-WAG/WA6
4.17Single8WGDWAG/WA68WGD-mGlu4; mGlu2-WAG/WA6
4.17Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
4.17Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
4.17Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.17Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.17Single8WVXNorrin8WVX-LGR4-Norrin
4.17Single8WVYNorrin8WVY-LGR4-Norrin
4.17Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
4.17Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
4.17Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
4.17Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
4.17Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
4.17Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
4.17Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
4.17Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
4.17Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
4.17Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
4.17Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
4.17Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
4.17Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
4.17Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
4.17Single8XUMR-spondin-28XUM-LGR4-R-spondin-2
4.17Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
4.17Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
4.17Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
4.17Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
4.17Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
4.17Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
4.17Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
4.17Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
4.17Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
4.17Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
4.17Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
4.17Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
4.17Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
4.17Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
4.17Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
4.17Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
4.17Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
4.17Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
4.17Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
4.17Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
4.00Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
4.00Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
4.00Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
4.00Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
4.00Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.00Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.00Single8W8SAA-148W8S-GPR101-AA-14
4.00Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
4.00Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
4.00Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
4.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
3.85Single7KNUCalcitonin gene-related peptide-17KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
3.85Single7T9MCS-17 Antibody7T9M-TSH-CS-17 Antibody
3.85Single8W8RAA-148W8R-GPR101-AA-14-chim(NtGi1-Gs)/β1/γ2
3.70Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
3.70Single7FIGhCG7FIG-LH-hCG-chim(NtGi1L-Gs)/β1/γ2
3.70Single7UTZTR14027UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
3.70Single7XW5TSH7XW5-TSH-TSH-ML109-Gs/β1/γ2
3.70Single7ZI0Cholesterol7ZI0-SMO-SAG-Cholesterol
3.70Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/β1/γ2
3.57Single5L7DCholesterol5L7D-SMO-Cholesterol
3.57Single7T9ITSH7T9I-TSH-TSH-Gs/β1/γ2
3.57Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
3.57Single8HS2Fab0468HS2-GPR20-Fab046
3.57Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
3.57Single8I2GGlycoprotein hormones alpha chain8I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
3.57Single9GE2Cholesterol9GE2-GPR55-ML184-Cholesterol-chim(CtGi1-G13)/β1/γ2
3.45Single2HPYAll-trans-Retinal2HPY-Rhodopsin-All-trans-Retinal
3.33Single7F61Cholesterol7F61-H3-PF-03654746-Cholesterol
3.33Single8J6QCompound 9n8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
3.23Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
3.23Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/β1/γ2
3.23Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
3.12Single7VVOPTH7VVO-PTH1-PTH-Gs/β1/γ2
3.12Single8G94CD698G94-S1P1-CD69-Gi1/β1/γ2
3.03Single6FFIMMPEP6FFI-mGlu5-MMPEP
3.03Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
2.94Single6FFHFenobam6FFH-mGlu5-Fenobam
2.86Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
2.78Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
2.78Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
2.50Single8XFTR-spondin-28XFT-LGR4-R-spondin-2-ZNRF3
2.50Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-Cholesterol-ZNRF3
2.38Single8WVUR-spondin-18WVU-LGR4-R-spondin-1-RNF43
2.38Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-Cholesterol-ZNRF3
2.33Single8XFPR-spondin-28XFP-LGR4-R-spondin-2-ZNRF3
2.17Single8XFSR-spondin-28XFS-LGR4-R-spondin-2-ZNRF3

Consensus Members
Id Members
7F4H 7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
7F54 7F54-MC4-Afamelanotide-Gs/β1/γ2
7F4D 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
8INR 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
7F53 7F53-MC4-α-MSH-Gs/β1/γ2
7F55 7F55-MC4-Bremelanotide-Gs/β1/γ2
8GY7 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
8IOC 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
8IOD 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
7AUE 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
7F4I 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
7F58 7F58-MC4-THIQ-Gs/β1/γ2
Net Summary
Imin 3.44
Number of Linked Nodes 904
Number of Links 1050
Number of Hubs 146
Number of Links mediated by Hubs 580
Number of Communities 25
Number of Nodes involved in Communities 195
Number of Links involved in Communities 280
Path Summary
Number Of Nodes in MetaPath 101
Number Of Links MetaPath 100
Number of Shortest Paths 1828595
Length Of Smallest Path 3
Average Path Length 29.9905
Length of Longest Path 55
Minimum Path Strength 0.333333
Average Path Strength 7.23903
Maximum Path Strength 22.6392
Minimum Path Correlation 0.700833
Average Path Correlation 0.974728
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2
Average % Of Corr. Nodes 36.9404
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 52.0465
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following consensuses:
IdComponents
gs_peptidegs_cck
gs_melanocortin
gs_vasop-oxy



You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download gs_melanocortin.zip



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