Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
1G.HN.11 3.5495402
2G.S1.02 4.634595
3G.S1.05 4.1235409
4G.H1.01 2.8524199
5G.S2.03 5.878419
6G.S2.08 6.8885495
7G.S3.03 7.724497
8G.S3.04 8.88416
9G.S3.06 6.7316515
10G.S3.07 2.61245199
11G.s3h2.03 2.891419
12G.H2.02 3.6525418
13G.H2.03 5.6144519
14G.H2.04 2.5175409
15G.H2.06 4.83933619
16G.H2.07 4.6288519
17G.h2s4.01 5.672419
18G.S4.04 4.8844539
19G.S4.06 3.6475407
20G.s4h3.01 4.2635437
21G.s4h3.04 5.84143738
22G.s4h3.05 6.332539
23G.s4h3.15 4.3885409
24G.H3.01 6.527434
25G.H3.09 4.8872539
26G.H3.12 2.627438
27G.H3.13 3.343435
28G.H3.17 5.457615
29G.H3.18 6.053419
30G.S5.03 2.8445408
31G.S5.04 3.521439
32G.S5.05 3.3566159
33G.S5.06 4.472438
34G.HG.04 4.991439
35G.HG.13 2.357437
36G.HG.15 3.6375407
37G.hgh4.02 4.91525217
38G.hgh4.05 6.943407
39G.H4.03 7.2696504
40G.H4.15 3.867408
41G.S6.02 4.759407
42G.S6.05 3.996434
43G.s6h5.05 2.6315409
44G.H5.03 4.04125158
45G.H5.08 4.2756598
46b.1x15 3.903467
47b.1x16 3.3265464
48b.1x19 3.216466
49b.lhb1x3 2.69125102
50b.lhb1x6 3.85645103
51b.lhb1x11 3.7095484
52b.b1x3 4.9484557
53b.b1x4 3.719457
54b.l1x3 7.08867659
55b.b2x1 5.4924518
56b.b2x5 5.7066117
57b.b3x3 2.7155408
58b.l3x2 4.1228559
59b.b4x4 7.0615458
60b.b4x6 8.02567659
61b.b5x2 5.247407
62b.b5x3 5.496759
63b.b5x5 4.641405
64b.b5x7 3.7625407
65b.l5x5 5.11486719
66b.b6x5 3.15533606
67b.l6x5 5.13154164
68b.l7x2 3.9144519
69b.b8x3 2.824516
70b.b8x4 4.14533606
71b.l8x3 2.502403
72b.b9x2 2.7685415
73b.b9x4 4.9115419
74b.l9x3 6.6512519
75b.l9x6 3.6815818
76b.b10x5 3.082719
77b.l10x1 3.6815403
78b.b11x4 5.759419
79b.b11x5 3.754476
80b.l11x2 6.0956519
81b.b12x6 8.718618
82b.b13x7 7.4744577
83b.l13x3 6.55633679
84b.l13x6 5.3844519
85b.l13x7 4.226479
86b.b14x3 3.524575
87b.b15x1 5.316579
88b.b15x2 4.4635466
89b.b15x3 3.783479
90b.l15x1 3.8364517
91b.l15x2 4.9984579
92b.b16x4 9.5915476
93b.b16x5 3.3644505
94b.b16x6 8.9832578
95b.b16x7 4.724179
96b.b17x4 3.66354175
97b.b17x5 5.6775467
98b.b17x7 6.126468
99b.l17x3 8.731669
100b.l17x6 6.08419
101b.b18x3 4.354468
102b.b18x5 4.515405
103b.l18x1 5.288577126
104b.l18x2 5.3324127
105b.b19x2 5.767666
106b.b19x4 4.5592568
107b.l19x2 6.9395469
108b.b20x4 9.2272568
109b.b20x6 6.9164566
110b.b21x1 5.75567
111b.b21x5 3.874404
112b.b21x7 4.19233605
113b.l21x5 3.3384134
114b.b22x5 4.195127
115b.l22x5 6.2816109
116b.b23x6 6.20565137
117b.l23x1 8.1075406
118b.l23x2 3.93654138
119b.b24x4 4.67925136
120b.b24x6 4.49565138
121b.l24x3 3.2555405
122b.b25x3 2.65154135
123b.b25x7 5.4915487
124b.l25x3 7.8589
125b.l25x7 3.1885487
126b.b26x3 3.3404506
127b.l27x1 10.0867619
128b.l27x2 4.5225489
129b.b28x3 2.835457
130b.b28x4 5.804486
131b.b28x6 7.2412589
132g.h1x12 2.169406
133g.l1x4 3.3075408
134g.h2x9 2.1695404
135g.h2x11 6.10454126
136g.ctx3 5.38167609
137g.ctx6 4.8314106
138g.ctx14 3.3316509
139g.ctx15 5.4785459
140g.ctx16 3.93575858
1411x31 0.8075405
1421x50 5.362409
1431x57 5.906548
1441x60 3.592507
1452x41 5.5575446
1462x43 4.394648
1472x46 3.1735449
1482x50 5.8904549
1492x51 3.0225188
1502x55 3.57165186
1512x57 3.5585428
1522x60 7.0784527
1532x63 4.80867626
1542x65 2.9996506
155E1x51 3.0115423
156E1x52 4.1164526
1573x28 5.3425407
1583x33 9.574428
1593x35 3.624406
1603x37 3.8055428
1613x51 7.09754149
1624x50 4.86445269
1634x54 2.7544275
1644x57 4.63533628
1654x62 2.82933627
166E2x51 3.2912524
167E2x52 5.619627
168E2.F168 4.59371726
169E2.F169 4.6828526
1705x38 5.7625424
1715x39 3.8895428
1725x40 3.618427
1735x46 6.5305427
1745x50 2.94429
1755x57 6.84854147
1765x62 2.761407
1776x29 3.2734237
1786x44 3.8495429
1796x48 6.355829
1806x51 7.34433627
1816x55 4.141427
182E3.K336 5.243424
1837x34 6.3412525
1847x38 9.4295426
1857x39 5.6912528
1867x42 6.7485828
1877x47 2.809406
1887x49 5.903449
1897x53 4.7192549
1908x47 3.7116549
1918x50 4.1748548
192Lig 7.7121320
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1b.l2x3 b.l2x5 26.94582.856NoNo085
2b.b3x1 b.l2x3 27.03144.884NoNo058
3b.b26x2 b.b2x3 10.60554.86NoNo076
4b.b26x1 b.b26x2 10.60032.752NoNo097
5b.b26x1 b.l27x1 10.63264.942NoYes099
6b.l3x1 b.l5x5 10.12584.382NoYes199
7b.b3x1 b.b6x5 27.02592.578NoYes056
8b.b6x5 b.b7x2 54.72912.774YesNo068
9b.b7x2 b.b8x4 54.82992.274NoYes086
10b.b8x4 b.l5x1 56.07374.218YesNo068
11b.b4x1 b.l5x1 56.30573.762NoNo088
12b.b4x1 b.l5x4 56.43032.23NoNo088
13b.l5x4 b.l5x5 56.56493.458NoYes089
14G.H2.08 G.H3.17 31.57622.35NoYes085
15G.H2.04 G.H2.08 32.00722.506YesNo098
16G.H2.04 G.H3.12 82.54222.254YesYes098
17G.H3.12 G.S4.04 1002.262YesYes389
18G.S4.04 G.S4.06 53.31173.406YesYes097
19G.S4.06 G.S5.06 42.25982.384YesYes078
20G.S5.06 G.s4h3.01 47.3636.922YesYes387
21G.HG.04 G.s4h3.01 46.95493.412YesYes397
22G.H4.03 G.HG.04 36.21084.744YesYes049
23G.H4.03 G.HG.01 69.65696.45YesNo045
24G.HG.01 G.s6h5.02 67.91662.264NoNo057
25G.H5.02 G.s6h5.02 66.1763.558NoNo047
26G.H5.02 G.s6h5.05 65.3064.424NoYes049
27G.H5.03 G.s6h5.05 62.69613.5YesYes089
28G.H5.03 G.S5.05 55.7083.626YesYes1589
29G.S5.03 G.S5.05 52.40643.264YesYes089
30G.S4.03 G.S5.03 31.61252.354NoYes078
31G.S1.04 G.S4.03 30.73434.568NoNo077
32G.S1.02 G.S1.04 28.97752.682YesNo057
33G.H3.17 b.l25x6 28.17962.6YesNo058
34G.S4.04 G.S5.04 43.08763.166YesYes399
35G.S5.04 G.S5.06 42.44242.492YesYes398
36G.S5.06 G.S6.05 36.90866.09YesYes384
37G.H4.07 G.S6.05 36.49212.77NoYes054
38G.H4.03 G.H4.07 36.0632.934YesNo045
39G.S1.02 G.S3.03 14.00877.342YesYes957
40G.h2s4.01 b.l5x5 35.57015.814YesYes199
41G.S1.05 G.h2s4.01 18.26667.062YesYes099
42G.H3.12 G.S1.07 18.14583.138YesNo089
43G.S1.05 G.S1.07 18.12745.26YesNo099
44G.H1.08 G.S3.05 10.52.02NoNo087
45G.H1.08 G.S2.06 11.38132.984NoNo089
46G.S2.06 G.S3.03 13.143313.288NoYes097
47b.b2x4 b.b6x5 78.42083.27NoYes066
48b.b10x4 b.b2x4 78.31289.028NoNo066
49b.b10x4 b.b14x3 40.23632.43NoYes065
50b.b10x2 b.b14x3 18.06755.08NoYes765
51b.b10x2 b.b6x2 19.19373.042NoNo068
52b.b10x3 b.b6x2 19.21363.38NoNo088
53b.b10x3 b.b8x1 19.23482.548NoNo088
54b.b11x4 b.b8x1 19.41162.704YesNo098
55b.b11x4 b.l9x3 18.92675.48YesYes199
56b.l5x5 b.l7x2 23.14475.012YesYes199
57G.H2.04 G.H2.07 63.18593.2YesYes099
58G.H2.07 G.h2s4.01 18.28563.808YesYes199
59G.H2.07 b.l7x2 31.09935.466YesYes199
60b.l7x2 b.l9x6 18.62413.046YesYes198
61G.H4.15 G.S4.06 10.4575.244YesYes087
62G.HG.04 G.s4h3.04 10.16565.778YesYes398
63G.s4h3.04 G.s4h3.05 10.567716.322YesYes389
64G.H5.10 G.S6.02 19.14914.804NoYes067
65G.H5.10 G.S5.03 20.0293.25NoYes068
66G.S6.02 G.h4s6.12 10.38138.532YesNo074
672x43 7x53 40.8632.888YesYes489
682x43 8x50 43.52565.788YesYes488
698x50 I1x50 44.92284.14YesNo489
701x60 I1x50 49.45633.8YesNo079
711x60 8x56 50.02984.424YesNo075
728x56 b.l25x4 50.10717.744NoNo055
73b.l25x4 b.l27x2 50.34781.862NoYes059
74b.l25x3 b.l27x2 50.31795.546YesYes899
75b.b27x3 b.l25x3 49.30596.028NoYes089
76b.b26x3 b.b27x3 49.29062.654YesNo068
77b.b26x3 b.b26x4 25.23482.394YesNo065
78b.b26x4 b.b2x5 22.02552.81NoYes1157
79b.b14x3 b.b15x1 56.352.926YesYes759
80b.b15x1 b.l16x1 53.95042.358YesNo094
81b.l16x1 b.l16x2 53.75562.354NoNo049
82b.l14x5 b.l16x2 90.11845.546NoNo059
83b.b16x7 b.l14x5 77.31932.858YesNo095
84b.b16x7 b.l14x6 37.95424.07YesNo093
85b.b16x5 b.l14x6 37.60483.044YesNo053
86b.b16x5 b.b17x5 41.03812.66YesYes057
87b.b17x5 b.b21x1 31.11079.922YesYes677
88b.1x19 b.b21x1 27.00362.144YesYes667
89b.1x15 b.1x19 21.99264.47YesYes676
90b.1x12 b.1x15 20.56746.268NoYes067
91b.1x12 b.1x9 19.85164.86NoNo064
92b.1x13 b.1x9 19.13573.41NoNo014
93b.1x10 b.1x13 18.41972.394NoNo011
94b.1x10 g.h1x12 11.25231.692NoYes016
95b.b10x4 b.b14x5 37.98532.672NoNo065
96b.b14x5 b.l10x1 37.85215.812NoYes053
97b.b11x1 b.l10x1 37.66762.394NoYes053
98b.b11x1 b.l16x2 36.73434.438NoNo059
99b.b16x7 b.b17x4 38.31055.716YesYes1795
100b.b16x5 b.b17x4 37.61893.156YesYes055
101b.b22x2 b.b26x3 27.16824.804NoYes086
102b.b22x1 b.b22x2 27.14212.88NoNo088
103b.b22x1 b.l23x1 27.11713.182NoYes086
104b.l2x5 b.l4x2 25.118621.812NoNo054
105b.l4x2 g.ctx16 20.68735.984NoYes548
106b.b2x5 b.l4x1 21.36214.94YesNo075
107b.l4x1 g.ctx16 21.29735.018NoYes058
108b.l11x1 b.l9x6 29.15753.19NoYes198
109b.b11x6 b.l11x1 29.15552.97NoNo199
110b.b11x6 b.l9x3 26.686215.064NoYes199
111b.l14x3 b.l14x5 12.47443.098NoNo055
112b.l14x1 b.l14x3 12.11962.78NoNo045
113b.b18x5 b.l14x1 11.77163.048YesNo054
114b.b15x2 b.b18x5 10.386.03YesYes065
115b.b15x2 b.b18x3 11.76464.914YesYes668
116b.b15x2 b.b16x5 20.69752.98YesYes065
117b.b15x2 b.b19x2 18.20173.93YesYes666
118b.b16x5 b.l20x1 12.83484.982YesNo056
119b.b19x2 b.l20x1 12.12273.412YesNo066
120b.b19x2 b.b20x6 12.477910.932YesYes666
121b.b19x4 b.l17x3 14.29277.122YesYes689
122b.b19x2 b.b19x4 16.06952.59YesYes668
123b.b20x4 b.b20x6 10.01684.276YesYes686
1246x48 7x45 36.45088.814YesNo099
1257x45 7x49 36.750310.898NoYes099
1263x43 7x49 36.30075.664NoYes499
1273x43 7x53 37.20687.978NoYes499
1286x48 Lig 25.59843.062YesYes290
1292x60 2x64 10.27719.738YesNo075
130b.l23x1 b.l25x6 30.928620.012YesNo068
131G.H2.07 G.s3h2.03 13.78863.068YesYes199
132G.s3h2.03 b.l9x6 13.31732.704YesYes198
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
2x563x328.8322NoNo8821
2x567x423.7082NoYes8821
2x577x392.3462YesYes8822
2x577x423.2882YesYes8821
2x607x388.8722YesYes7621
2x607x392.3142YesYes7822
2x607x424.4362YesYes7821
3x327x4211.392NoYes8811
3x32Lig7.6622NoYes8010
3x334x5712.3262YesYes8811
3x334x625.0782YesYes8712
3x33E2x525.8382YesYes8712
3x33Lig15.0542YesYes8010
3x366x482.6122NoYes8911
3x367x422.612NoYes8811
3x36Lig5.5082NoYes8010
3x373x415.2462YesNo8712
3x374x533.362YesNo8812
3x374x573.512YesYes8811
3x406x443.672NoYes8922
3x406x487.6022NoYes8921
3x414x563.030NoNo7722
4x564x573.5480NoYes7821
4x574x622.552YesYes8712
4x575x432.3382YesNo8811
4x62E2x522.3722YesYes7722
5x455x462.680NoYes4721
5x466x487.632YesYes7911
5x46Lig13.1682YesYes7010
5x476x482.4040NoYes9921
6x446x486.0122YesYes9921
6x487x4112.7042YesNo9811
6x487x458.8142YesNo9912
6x48Lig3.0622YesYes9010
6x517x348.142YesYes7512
6x517x373.4682YesNo7512
6x517x388.6682YesYes7611
6x517x418.1162YesNo7811
6x51Lig8.6822YesYes7010
7x387x426.4162YesYes6811
7x38Lig13.7622YesYes6010
7x397x4210.6842YesYes8821
7x41Lig11.712NoYes8010
7x42Lig11.4562YesYes8010
3x37Lig3.1062YesYes8010
4x565x462.6440NoYes7721
5x446x524.2380NoNo8812
6x516x556.9922YesYes7712
6x557x342.9962YesYes7522
4x57Lig3.542YesYes8010
5x43Lig2.432NoYes8010
5x446x561.8560NoNo8612
5x44Lig1.1160NoYes8010

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
85.71Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
84.62Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
80.00Single5CXVTiotropium5CXV-M1-Tiotropium
80.00Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
80.00Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
76.92Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
73.33Single4U15Tiotropium4U15-M3-Tiotropium
73.33Single6OL9Tiotropium6OL9-M5-Tiotropium
73.33Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
73.33Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
73.33Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
73.33Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
73.33Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
71.43Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
71.43Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
69.23Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
69.23Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
69.23Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
69.23Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
69.23Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ2
69.23Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
69.23Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
68.75Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
66.67Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
66.67Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
66.67Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
66.67Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
66.67Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
64.71Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
64.71Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
64.71Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
64.29Single7T94Acetylcholine7T94-M2-Acetylcholine-LY2119620-chim(NtGi1-Go)/β1/γ2
64.29Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
62.50Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
62.50Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
62.50Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
62.50Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
61.54Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
61.54Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
61.54Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
61.54Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
60.00Single4DAJTiotropium4DAJ-M3-Tiotropium
60.00Single4MQSIperoxo4MQS-M2-Iperoxo
60.00Single4U14Tiotropium4U14-M3-Tiotropium
60.00Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
60.00Single5DSGTiotropium5DSG-M4-Tiotropium
60.00Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
60.00Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
60.00Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
60.00Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
60.00Single8YN8Proxyfan8YN8-H3-Proxyfan-Go/β1/γ2
60.00Single9JEAAtropine9JEA-M1-Atropine
60.00Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
60.00Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
58.82Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
58.82Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
57.14Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
57.14Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
57.14Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
56.25Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
56.25Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
56.25Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
56.25Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
56.25Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
55.56Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
55.56Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
55.56Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
53.85Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
53.85Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
53.85Single8IW72-Phenylethylamine8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
53.85Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
53.85Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
53.85Single9LRCHistamine9LRC-H4-Histamine
53.85Single9LREHistamine9LRE-H4-Histamine-Gi1/β1/γ2
53.85Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
53.85Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
53.33Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
53.33Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
53.33Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
53.33Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
53.33Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
53.33Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
53.33Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
53.33Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
53.33Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
53.33Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
53.33Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
53.33Single9LRDHistamine9LRD-H1-Histamine-Gi1/β1/γ2
53.33Consensusalpha1_onOrthosteric Ligandalpha1a_on
53.33Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
53.33Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
53.33Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
52.94Single2YDVNECA2YDV-A2A-NECA
52.94Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
52.94Single4UHRCGS216804UHR-A2A-CGS21680
52.94Single5G53NECA5G53-A2A-NECA-Gs
52.94Single5V54Methiothepin5V54-5-HT1B-Methiothepin
52.94Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
52.94Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
52.94Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
52.94Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
52.94Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
52.94Single8EA0Iperoxo8EA0-M3-Iperoxo
52.94Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
52.94Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
52.94Single9AS9RS130-1809AS9-5-HT2A-RS130-180
52.94Single9ASARS130-1809ASA-5-HT2A-RS130-180-chim(NtGi1-Gs-CtGq)/β1/γ2
52.94Consensus5ht1_offOrthosteric Ligand5ht1b_off
52.94Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
52.94Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
52.94Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
52.94Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
52.63Single7SK9CCX6627SK9-ACKR3-CCX662
50.00Single3D4STimolol3D4S-β2-Timolol
50.00Single3NY8ICI118-5513NY8-β2-ICI118-551
50.00Single4EJ4Naltrindole4EJ4-δ-Naltrindole
50.00Single4GBRS-Carazolol4GBR-β2-S-Carazolol
50.00Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
50.00Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
50.00Single6ZG4HTL00099366ZG4-M1-HTL0009936
50.00Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
50.00Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
50.00Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
50.00Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
50.00Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
50.00Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
50.00Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
50.00Single8JXRLSD8JXR-D1-LSD
50.00Single8T1WCVN4248T1W-GPR6-CVN424
50.00Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
50.00Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
50.00Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
50.00Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
50.00Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
50.00Single8YN7Immethridine8YN7-H3-Immethridine-Go/β1/γ2
50.00Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
50.00Single9AS1DMT9AS1-5-HT2A-DMT
50.00Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
50.00Single9EBIPiclidenoson9EBI-A3A-Piclidenoson-chim(NtGi1L-Gs-CtGi1)/β1/γ2
50.00Single9EPRRetinal9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
50.00Single9PLNN-(5-methylnaphthalen-1-yl)pyridin-4-amine9PLN-α2a-N-(5-methylnaphthalen-1-yl)pyridin-4-amine
50.00Single9PLON-(5-methylnaphthalen-1-yl)pyridin-4-amine9PLO-α2a-N-(5-methylnaphthalen-1-yl)pyridin-4-amine-Go/β1/γ2
50.00Single9PQD(6m)-1-methyl-6-(1,2,5,6-tetrahydropyridin-3-yl)-1h-indole9PQD-α2a-(6m)-1-methyl-6-(1,2,5,6-tetrahydropyridin-3-yl)-1h-indole
50.00Consensusalpha2_onOrthosteric Ligandalpha2b_on
50.00Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
50.00Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
50.00Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
50.00Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
50.00Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
50.00Consensusdopamine_offOrthosteric Ligandd2_off d3_off
50.00Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
50.00Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
50.00Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
47.37Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
47.37Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
47.37Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
47.37Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
47.37Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
47.37Single8S2TIsoprenaline8S2T-β1-Isoprenaline-chim(NtGi1-Gs)/β1/γ2
47.37Single9AS02-bromo-LSD9AS0-5-HT2A-2-bromo-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
47.06Single2RH1S-Carazolol2RH1-β2-S-Carazolol
47.06Single2YCWS-Carazolol2YCW-β1-S-Carazolol
47.06Single5D6LS-Carazolol5D6L-β2-S-Carazolol
47.06Single5JQHS-Carazolol5JQH-β2-S-Carazolol
47.06Single5X7DS-Carazolol5X7D-β2-S-Carazolol-Cmpd-15
47.06Single6PS6Timolol6PS6-β2-Timolol
47.06Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
47.06Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
47.06Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
47.06Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
47.06Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
47.06Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
47.06Single9ARZ2-bromo-LSD9ARZ-5-HT2A-2-bromo-LSD
47.06Single9DYDAsenapine9DYD-5-HT1A-Asenapine-Go/β1/γ2
47.06Single9DYFAsenapine9DYF-5-HT1A-Asenapine-Gi1/β1/γ2
47.06Single9EE8Adenosine9EE8-A2A-Adenosine-Gs/β1/γ2
47.06Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
47.06Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
47.06Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
47.06Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
47.06Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
47.06Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
47.06Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
47.06Consensusamine_offonOrthosteric Ligandamine_off amine_on
47.06Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
47.06Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
47.06Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
47.06Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
47.06Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
47.06Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
47.06Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
47.06Consensustrace-amine_onOrthosteric Ligandta1_on
46.67Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
46.67Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
46.67Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
46.67Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
46.67Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
46.67Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
46.67Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
46.67Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
46.67Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
46.67Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
46.67Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
46.67Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
46.67Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
46.67Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
46.67Single8IWESpermidine8IWE-TA9-Spermidine
46.67Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
46.67Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
46.67Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
46.67Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
46.67Single8Y0HVUF114188Y0H-CXCR3-VUF11418
46.67Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go/β1/γ2
46.67Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
46.67Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
46.67Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
46.67Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
46.67Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
46.15Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
46.15Single8IWM2-Phenylethylamine8IWM-TA9-2-Phenylethylamine
46.15Single8WC5Tetramethylammonium Ion8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
45.00Single3NY9ICI118-5513NY9-β2-ICI118-551
45.00Single4UG2CGS216804UG2-A2A-CGS21680
45.00Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
44.44Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
44.44Single5D5AS-Carazolol5D5A-β2-S-Carazolol
44.44Single5D5BS-Carazolol5D5B-β2-S-Carazolol
44.44Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
44.44Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
44.44Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
44.44Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
44.44Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
44.44Single9BJKNaloxone9BJK-μ-Naloxone-NAM
44.44Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
44.44Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
44.44Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
44.44Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
43.75Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
43.75Single2YDOAdenosine2YDO-A2A-Adenosine
43.75Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
43.75Single3RZECidoxepin3RZE-H1-Cidoxepin
43.75Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
43.75Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
43.75Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
43.75Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
43.75Single6PS0S-Carazolol6PS0-β2-S-Carazolol
43.75Single6PS4ICI118-5516PS4-β2-ICI118-551
43.75Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
43.75Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
43.75Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
43.75Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
43.75Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
43.75Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
43.75Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
43.75Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
43.75Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
43.75Single7UL3Famotidine7UL3-H2-Famotidine
43.75Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
43.75Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
43.75Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
43.75Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
43.75Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
43.75Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
43.75Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
43.75Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
43.75Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
43.75Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
43.75Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
43.75Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
43.75Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
43.75Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
43.75Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
43.75Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
43.75Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
43.75Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
43.75Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
43.75Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
43.75Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
43.75Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
43.75Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
43.75Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
43.75Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
43.75Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
43.75Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
43.75Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
42.86Single3PQRAll-trans-Retinal3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
42.86Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
42.86Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
42.86Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
42.86Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
42.86Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
42.86Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
42.86Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
42.86Single8WDTphotoNECA8WDT-A2A-photoNECA
42.86Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
42.86Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
42.86Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
42.86Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
42.86Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
42.11Single4AMIBucindolol4AMI-β1-Bucindolol
42.11Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
42.11Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
42.11Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
42.11Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
42.11Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
42.11Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
42.11Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
42.11Single7YITNalfurafine7YIT-κ-Nalfurafine
42.11Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
42.11Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
42.11Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
42.11Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
42.11Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
42.11Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
42.11Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
42.11Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
42.11Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
42.11Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
42.11Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
41.18Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
41.18Single2Y04Salbutamol2Y04-β1-Salbutamol
41.18Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
41.18Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
41.18Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
41.18Single4QKX35V4QKX-β2-35V
41.18Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
41.18Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
41.18Single6H7MSalbutamol6H7M-β1-Salbutamol
41.18Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
41.18Single6TOTLemborexant6TOT-OX1-Lemborexant
41.18Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
41.18Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
41.18Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
41.18Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
41.18Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
41.18Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
41.18Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
41.18Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
41.18Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
41.18Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
41.18Single7WC7Lisuride7WC7-5-HT2A-Lisuride
41.18Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
41.18Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
41.18Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
41.18Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
41.18Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
41.18Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
41.18Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
41.18Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
41.18Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
41.18Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
41.18Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
41.18Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
41.18Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
41.18Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
41.18Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
41.18Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
41.18Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
41.18Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
41.18Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
41.18Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
41.18Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
41.18Single8JJOAlprenolol8JJO-β2-Alprenolol
41.18Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
41.18Single8PJKST1718PJK-5-HT1A-ST171-Gi1/β1/γ1
41.18Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
41.18Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
41.18Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
41.18Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
41.18Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
41.18Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
41.18Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
41.18Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
41.18Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
41.18Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
41.18Single8X63Mepyramine8X63-H1-Mepyramine
41.18Single8X64Desloratadine8X64-H1-Desloratadine
41.18Single9CHXS-Carazolol9CHX-β2-S-Carazolol
41.18Single9KFJPubChem 1383196749KFJ-RXFP3-PubChem 138319674-Gi2/β1/γ2
41.18Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
41.18Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
41.18Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
41.18Consensus5ht5_onOrthosteric Ligand5ht5a_on
41.18Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
41.18Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
41.18Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
41.18Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
41.18Consensusblt_onOrthosteric Ligandblt1_on
41.18Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
41.18Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
41.18Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
41.18Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
41.18Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
41.18Consensushistamine_offOrthosteric Ligandh1_off
41.18Consensusleukotriene_onOrthosteric Ligandblt_on
41.18Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
40.00Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
40.00Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
40.00Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
40.00Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
40.00Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
40.00Single5X93K-87945X93-ETB-K-8794
40.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
40.00Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
40.00Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
40.00Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
40.00Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
40.00Single7SRQLSD7SRQ-5-HT2B-LSD
40.00Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
40.00Single7UM4AS26747237UM4-5-HT5A-AS2674723
40.00Single7V68Iperoxo7V68-M4-Iperoxo-LY2119620-Gi1/β1/γ2
40.00Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
40.00Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
40.00Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
40.00Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
40.00Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
40.00Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
40.00Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
40.00Single8XVJMacitentan8XVJ-ETA-Macitentan
40.00Single8YN2Histamine8YN2-H1-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
40.00Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
40.00Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
40.00Single9CGJC6-Quino9CGJ-δ-C6-Quino-Gi1/β1/γ2
40.00Single9DYEBuspirone9DYE-5-HT1A-Buspirone-Go/β1/γ2
40.00Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
40.00Single9IXJHistamine9IXJ-H2-Histamine-Gs/β1/γ2
40.00Consensusendothelin_offOrthosteric Ligandetb_off
40.00Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
40.00Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
40.00Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
39.13Single5WF5UK-4320975WF5-A2A-UK-432097
38.89Single2Y03Isoprenaline2Y03-β1-Isoprenaline
38.89Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
38.89Single5C1MBU725C1M-μ-BU72
38.89Single5CGCHTL142425CGC-mGlu5-HTL14242
38.89Single5TVNLSD5TVN-5-HT2B-LSD
38.89Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
38.89Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
38.89Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
38.89Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
38.89Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
38.89Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
38.89Single6TP6Filorexant6TP6-OX1-Filorexant
38.89Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
38.89Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
38.89Single7LD3Adenosine7LD3-A1-Adenosine-MIPS521-Gi2/β1/γ2
38.89Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
38.89Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
38.89Single7WC6LSD7WC6-5-HT2A-LSD
38.89Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
38.89Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
38.89Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
38.89Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
38.89Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
38.89Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
38.89Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
38.89Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
38.89Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
38.89Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
38.89Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
38.89Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
38.89Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
38.89Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
38.89Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
38.89Single8ZMFA1L108ZMF-5-HT2C-A1L10
38.89Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
38.89Single9ARYSerotonin9ARY-5-HT2A-Serotonin-chim(NtGi1-Gs-CtGq)/β1/γ2
38.89Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
38.89Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
38.89Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
38.89Single9F33FOB02-04A9F33-D3-FOB02-04A-Go/β1/γ2
38.89Single9F34FOB02-04A9F34-D3-FOB02-04A-Go/β1/γ2
38.89Single9K07DSO-5a9K07-BB3-DSO-5a-chim(NtGi2L-Gs-CtGq)/β1/γ2
38.89Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
38.89Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
38.89Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
38.89Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
38.89Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
38.89Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
38.89Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
38.46Single3PXOAll-trans-Retinal3PXO-Rhodopsin-All-trans-Retinal
38.46Single5DYSAll-trans-Retinal5DYS-Rhodopsin-All-trans-Retinal
38.10Single5ZTYAM102575ZTY-CB2-AM10257
38.10Single6PT3DPI-2876PT3-δ-DPI-287
38.10Single8X5YAstemizole8X5Y-H1-Astemizole
38.10Single9CGKC5-Quino9CGK-δ-C5-Quino-Gi1/β1/γ2
38.10Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
38.10Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
38.10Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
37.50Single6AKXA4R6AKX-CCR5-A4R
37.50Single6AKYMaraviroc6AKY-CCR5-Maraviroc
37.50Single6B73MP11046B73-κ-MP1104
37.50Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
37.50Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
37.50Single6TODEMPA6TOD-OX1-EMPA-Na
37.50Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
37.50Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
37.50Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
37.50Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
37.50Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
37.50Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
37.50Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
37.50Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
37.50Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
37.50Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
37.50Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
37.50Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
37.50Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
37.50Single9EBHAdenosine9EBH-A3A-Adenosine-Gi1/β1/γ2
37.50Single9EEAAdenosine9EEA-A2A-Adenosine-Gs/β1/γ2
37.50Single9LRBHistamine9LRB-H1-Histamine-Gs/β1/γ2
37.50Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
37.50Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
37.50Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
37.50Consensusalpha2_offOrthosteric Ligandalpha2c_off
37.50Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
37.50Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
36.84Single4DJHJDTic4DJH-κ-JDTic
36.84Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
36.84Single6H7JIsoprenaline6H7J-β1-Isoprenaline
36.84Single6J21Aprepitant6J21-NK1-Aprepitant
36.84Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
36.84Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
36.84Single6TQ7SB-3348676TQ7-OX1-SB-334867
36.84Single6WGTLSD6WGT-5-HT2A-LSD
36.84Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
36.84Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
36.84Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
36.84Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
36.84Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
36.84Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
36.84Single8E0GBU728E0G-μ-BU72
36.84Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
36.84Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
36.84Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
36.84Single8XVLZibotentan8XVL-ETA-Zibotentan
36.84Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
36.84Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
36.84Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
36.84Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
36.84Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
36.84Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
36.84Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
36.84Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
36.84Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
36.84Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
36.84Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
36.84Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
36.84Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
36.36Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
36.36Single4IARErgotamine4IAR-5-HT1B-Ergotamine
36.36Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
36.36Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
36.36Single8PKMBefiradol8PKM-5-HT1A-Befiradol-Gi1/β1/γ1
36.36Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
36.36Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
35.71Single2HPYAll-trans-Retinal2HPY-Rhodopsin-All-trans-Retinal
35.71Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
35.71Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
35.71Single8Y02Retinal8Y02-OPN1SW-Retinal-Gi1/β1/γ2
35.71Single9CHUNoradrenaline9CHU-β2-Noradrenaline
35.71Consensusgs_histamineOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
35.71Consensush2_onOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
35.71Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
35.71Consensussensory_onOrthosteric Ligandopsins_on
35.29Single4MBSMaraviroc4MBS-CCR5-Maraviroc
35.29Single4ZJCSB-6740424ZJC-OX1-SB-674042
35.29Single6A94Zotepine6A94-5-HT2A-Zotepine
35.29Single6KUXRS-799486KUX-α2a-RS-79948
35.29Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
35.29Single6PS5S-Propranolol6PS5-β2-S-Propranolol
35.29Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
35.29Single6TPGEMPA6TPG-OX2-EMPA
35.29Single6TPNHTL66416TPN-OX2-HTL6641
35.29Single6VI4JDTic6VI4-κ-JDTic
35.29Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
35.29Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
35.29Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
35.29Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
35.29Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
35.29Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
35.29Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
35.29Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
35.29Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
35.29Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
35.29Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
35.29Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
35.29Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
35.29Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
35.29Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
35.29Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
35.29Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
35.29Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
35.29Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
35.29Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
35.29Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
35.29Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
35.29Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
35.29Single9ARXSerotonin9ARX-5-HT2A-Serotonin
35.29Single9AS5Mescaline9AS5-5-HT2A-Mescaline
35.29Single9AS6Mescaline9AS6-5-HT2A-Mescaline-chim(NtGi1-Gs-CtGq)/β1/γ2
35.29Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
35.29Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
35.29Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
35.29Consensusopsins_offOrthosteric Ligandrhodopsin_off
35.29Consensussensory_offOrthosteric Ligandopsins_off
35.00Single4LDEBI1671074LDE-β2-BI167107
35.00Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
35.00Single4RWADIPP-NH24RWA-δ-DIPP-NH2
35.00Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
35.00Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
35.00Single6A93Risperidone6A93-5-HT2A-Risperidone
35.00Single6CM4Risperidone6CM4-D2-Risperidone
35.00Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
35.00Single7DFPSpiperone7DFP-D2-Spiperone
35.00Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
35.00Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
35.00Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
35.00Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
35.00Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
35.00Single8JD3JNJ-404118138JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
35.00Single8JJ8Formoterol8JJ8-β2-Formoterol
35.00Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
35.00Consensusalpha1_offOrthosteric Ligandalpha1a_off
35.00Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
35.00Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
35.00Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
35.00Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
35.00Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
35.00Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
35.00Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
35.00Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
34.78Single3QAKUK-4320973QAK-A2A-UK-432097
34.78Single6HLOAprepitant6HLO-NK1-Aprepitant
34.78Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
33.33Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
33.33Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
33.33Single2Y01Dobutamine2Y01-β1-Dobutamine
33.33Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
33.33Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
33.33Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
33.33Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
33.33Single5CGDHTL142425CGD-mGlu5-HTL14242
33.33Single5TGZAM65385TGZ-CB1-AM6538
33.33Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
33.33Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
33.33Single6DRXLisuride6DRX-5-HT2B-Lisuride
33.33Single6H7LDobutamine6H7L-β1-Dobutamine
33.33Single6IBLArformoterol6IBL-β1-Arformoterol
33.33Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
33.33Single6PS1Timolol6PS1-β2-Timolol
33.33Single6PT2KGCHM076PT2-δ-KGCHM07
33.33Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
33.33Single7BU7BI1671077BU7-β1-BI167107
33.33Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
33.33Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
33.33Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
33.33Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
33.33Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
33.33Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
33.33Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
33.33Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
33.33Single7UL4Alvimopan7UL4-μ-Alvimopan
33.33Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
33.33Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
33.33Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
33.33Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
33.33Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
33.33Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
33.33Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
33.33Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
33.33Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
33.33Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
33.33Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
33.33Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
33.33Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
33.33Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
33.33Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
33.33Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
33.33Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
33.33Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
33.33Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
33.33Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
33.33Consensus5ht2_onOrthosteric Ligand5ht2b_on
33.33Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
33.33Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
33.33Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
33.33Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
33.33Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
33.33Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
33.33Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
33.33Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
33.33Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
33.33Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
33.33Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
33.33Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
32.00Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
32.00Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
31.82Single5WF6UK-4320975WF6-A2A-UK-432097
31.82Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
31.82Single9MD1Buspirone9MD1-5-HT1A-Buspirone-Gz/β1/γ2
31.58Single2Y00Dobutamine2Y00-β1-Dobutamine
31.58Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
31.58Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
31.58Single5WIUNemonapride5WIU-D4-Nemonapride
31.58Single5WIVNemonapride5WIV-D4-Nemonapride-Na
31.58Single5WQCEMPA5WQC-OX2-EMPA
31.58Single5XPRBosentan5XPR-ETB-Bosentan
31.58Single6E67BI1671076E67-β2-BI167107-Gs(CT)
31.58Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
31.58Single6HLPNetupitant6HLP-NK1-Netupitant
31.58Single7C61Ergotamine7C61-5-HT1B-Ergotamine
31.58Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
31.58Single7SINNPS-21437SIN-CaS-NPS-2143
31.58Single7SINNPS-21437SIN-CaS-NPS-2143
31.58Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
31.58Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
31.58Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
31.58Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
31.58Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
31.58Single8TF5Oleic acid8TF5-GPR6-Oleic acid
31.58Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
31.58Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
31.58Single8XYKVUF106618XYK-CXCR3-VUF10661-Go/β1/γ2
31.58Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
31.58Single9HAPTolvaptan9HAP-V2-Tolvaptan
31.58Single9I52A1IZU9I52-D1-A1IZU-Gs/β1/γ2
31.58Consensusa3_on_gpOrthosteric Liganda3a_on_gp
31.58Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
31.58Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
31.58Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
31.25Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
31.25Single3PBLEticlopride3PBL-D3-Eticlopride
31.25Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
31.25Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
31.25Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
31.25Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
31.25Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
31.25Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
31.25Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
31.25Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
31.25Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
31.25Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
31.25Single9AS2DMT9AS2-5-HT2A-DMT-chim(NtGi1-Gs-CtGq)/β1/γ2
31.25Single9AS7Psilocin9AS7-5-HT2A-Psilocin
31.25Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
31.25Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
31.25Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
30.77Single4A4MAll-trans-Retinal4A4M-Rhodopsin-All-trans-Retinal-Gt(CT)
30.77Single5EN0All-trans-Retinal5EN0-Rhodopsin-All-trans-Retinal-Gt(CT)
30.43Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
30.43Single7QA8Peptide7QA8-STE2-Peptide
30.43Single7QA8Peptide7QA8-STE2-Peptide
30.43Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
30.43Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
30.43Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
30.43Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
30.43Single9BUYLM1899BUY-β2-LM189-Gi1/β1/γ2
30.43Single9M4TSilodosin9M4T-Alpha1A-Silodosin
30.43Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
30.00Single3P0GBI1671073P0G-β2-BI167107
30.00Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
30.00Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
30.00Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
30.00Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
30.00Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
30.00Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
30.00Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
30.00Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
30.00Single7P2L4YI7P2L-mGlu5-4YI
30.00Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
30.00Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
30.00Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
30.00Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
30.00Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
30.00Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
30.00Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
30.00Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
30.00Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
30.00Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
30.00Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
30.00Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
30.00Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
30.00Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
30.00Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
30.00Consensusa2_onOrthosteric Liganda2b_on
30.00Consensusa2_on_gpOrthosteric Liganda2b_on_gp
30.00Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
30.00Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
30.00Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
30.00Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
30.00Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
30.00Consensustachykinin_offOrthosteric Ligandnk1_off
29.41Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
29.41Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
29.41Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
29.41Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
29.41Single4S0VSuvorexant4S0V-OX2-Suvorexant
29.41Single5WS3EMPA5WS3-OX2-EMPA
29.41Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
29.41Single6ME2Ramelteon6ME2-MT1-Ramelteon
29.41Single6TPJSuvorexant6TPJ-OX2-Suvorexant
29.41Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
29.41Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
29.41Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
29.41Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
29.41Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
29.41Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
29.41Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
29.41Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
29.41Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
29.41Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
29.41Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
29.41Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
29.41Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.41Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.41Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
29.41Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
29.41Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
29.41Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
29.41Single9KPESA09KPE-TAS2R16-SA0-Gi1/β1/γ2
29.41Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
29.41Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
29.41Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
29.41Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
29.41Consensusorexin_offOrthosteric Ligandox2_off ox1_off
29.41Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
29.41Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
29.41Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
29.17Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
29.17Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
29.17Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
28.57Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
28.57Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
28.57Single6MXTSalmeterol6MXT-β2-Salmeterol
28.57Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
28.57Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
28.57Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
28.57Single7K15MKD0467K15-BLT1-MKD046-Na
28.57Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
28.57Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
28.57Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
28.57Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
28.57Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
28.57Single8JJLOlodaterol8JJL-β2-Olodaterol
28.57Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
28.57Single8XYIVUF106618XYI-CXCR3-VUF10661
28.57Single9GL2Befiradol9GL2-5-HT1A-Befiradol-Gs/β1/γ2
28.57Single9M4QDoxazosin9M4Q-Alpha1A-Doxazosin
28.57Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
28.57Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
28.57Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
28.57Consensuslpa_offOrthosteric Ligandlpa1_off
28.57Consensusorexin_onOrthosteric Ligandox2_on
28.00Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
28.00Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
28.00Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
28.00Consensusangiotensin_onOrthosteric Ligandat1_on
28.00Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
27.78Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
27.78Single6FFIMMPEP6FFI-mGlu5-MMPEP
27.78Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
27.78Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
27.78Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
27.78Single6TP3Nemorexant6TP3-OX1-Nemorexant
27.78Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
27.78Single6ZG9GSK10347026ZG9-M1-GSK1034702
27.78Single7F61PF-036547467F61-H3-PF-03654746
27.78Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
27.78Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
27.78Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
27.78Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
27.78Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
27.78Single8RLNLUF58348RLN-A2A-LUF5834
27.78Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
27.78Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
27.78Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
27.78Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
27.78Single9AS3LSD9AS3-5-HT2A-LSD
27.78Single9AS4LSD9AS4-5-HT2A-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
27.78Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
27.78Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
27.78Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
27.78Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
27.78Single9JH3CMF-0199JH3-Apelin-CMF-019-Gi1/β1/γ2
27.78Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
27.78Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
27.78Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
27.27Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
27.27Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
27.27Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
27.27Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
27.27Single7EZCUKA7EZC-A2A-UKA
27.27Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
27.27Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
27.27Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
27.27Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
27.27Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
27.27Single9M54Neuropeptide VF9M54-NPFF2-Neuropeptide VF-Gi1/β1/γ2
27.27Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
27.27Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
27.27Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
26.92Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
26.92Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
26.92Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
26.92Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
26.92Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
26.92Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
26.92Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
26.92Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
26.67Single6OY9All-trans-Retinal6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
26.67Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
26.67Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
26.67Single9EE9Adenosine9EE9-A2A-Adenosine-Gs/β1/γ2
26.32Single2Y02Carmoterol2Y02-β1-Carmoterol
26.32Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
26.32Single5DHHSB-6121115DHH-NOP-SB-612111
26.32Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
26.32Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
26.32Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
26.32Single6FFHFenobam6FFH-mGlu5-Fenobam
26.32Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
26.32Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
26.32Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
26.32Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
26.32Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
26.32Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
26.32Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
26.32Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
26.32Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
26.32Consensusa3_onOrthosteric Liganda3a_on
26.32Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
26.32Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
26.09Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
26.09Single7XN9L-054,5227XN9-SST2-L-054,522
26.09Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
26.09Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
26.09Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
26.09Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
26.09Single8Y72Peptide8Y72-μ-Peptide-BMS-986122-Gi1/β1/γ2
26.09Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
26.09Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
26.09Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
26.09Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
25.93Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
25.93Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
25.93Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
25.93Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
25.00Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
25.00Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
25.00Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
25.00Single6LUQHaloperidol6LUQ-D2-Haloperidol
25.00Single7C4SS1P7C4S-S1P3-S1P
25.00Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
25.00Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
25.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
25.00Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
25.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
25.00Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
25.00Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
25.00Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
25.00Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
25.00Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
25.00Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
25.00Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
25.00Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
25.00Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
25.00Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
25.00Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
25.00Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
25.00Single8JXSPF-61428JXS-D1-PF-6142
25.00Single8S4DCMF-0198S4D-Apelin-CMF-019
25.00Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
25.00Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
25.00Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
25.00Single9BLWCagrilintide backbone (non-acylated)9BLW-CT (AMY1)-Cagrilintide backbone (non-acylated)-Gs/β1/γ2; RAMP1
25.00Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
25.00Single9HC04YI9HC0-mGlu5-4YI
25.00Single9KFKRelaxin-39KFK-RXFP4-Relaxin-3-Gi2/β1/γ2
25.00Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
25.00Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
25.00Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
25.00Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
25.00Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
25.00Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
25.00Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
25.00Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
25.00Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
25.00Consensusgi_sensoryOrthosteric Ligandgi_opsins
25.00Consensuslpl_onOrthosteric Ligands1p_on lpa_on
25.00Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
25.00Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
25.00Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
25.00Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
25.00Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
25.00Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
24.14Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
24.14Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
24.14Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
24.14Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
24.14Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
24.14Single9BUCCagrilintide9BUC-CT-Cagrilintide-Gs/β1/γ2
24.14Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
24.14Single9KDFRES-701-39KDF-ETB-RES-701-3
24.14Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
24.00Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
24.00Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
24.00Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
24.00Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
24.00Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
24.00Single9IK8SST analogue9IK8-SST1-SST analogue-Gi1/β1/γ2
24.00Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
24.00Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
24.00Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
23.81Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
23.81Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
23.81Single5XR8AM8415XR8-CB1-AM841
23.81Single5XRAAM115425XRA-CB1-AM11542
23.81Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
23.81Single6E59L-7607356E59-NK1-L-760735
23.81Single6J20Aprepitant6J20-NK1-Aprepitant
23.81Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
23.81Single7B6WCyclazosin7B6W-α1b-Cyclazosin
23.81Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
23.81Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
23.81Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
23.81Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
23.81Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
23.81Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
23.81Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
23.81Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
23.81Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
23.81Single8YNTSNAP-948478YNT-MCH1-SNAP-94847
23.81Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
23.81Single9I54A1IZV9I54-D1-A1IZV-Gs/β1/γ2
23.81Single9IK9SST analogue9IK9-SST1-SST analogue-Gi1/β1/γ2
23.81Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
23.81Single9JMCDS-3801b9JMC-Motilin-DS-3801b-chim(Gs-CtGq)/β1/γ2
23.81Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
23.81Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
23.81Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
23.53Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
23.53Single6HLLCP999946HLL-NK1-CP99994
23.53Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
23.53Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
23.53Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
23.53Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
23.53Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
23.53Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
23.53Single8K5BNiacin8K5B-HCA2-Niacin
23.53Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.53Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
23.53Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
23.53Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
23.33Single6IGLIRL16206IGL-ETB-IRL1620
23.33Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
23.33Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
23.33Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
23.08Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
23.08Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
23.08Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
23.08Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
23.08Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
23.08Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
23.08Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
23.08Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
22.73Single5TZYMK8666; AP85TZY-FFA1-MK8666; AP8
22.73Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
22.73Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
22.73Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
22.73Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
22.73Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
22.73Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73Single8JWY2-1188JWY-A2A-2-118
22.73Single8JWZAB9288JWZ-A2A-AB928-Na
22.73Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
22.73Single8XJNCloprosetnol8XJN-TXA2-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73Single9DGIZ85267113509DGI-CB1-Z8526711350
22.73Single9GGGI-BOP9GGG-TXA2-I-BOP-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.73Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
22.73Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
22.73Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
22.73Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
22.73Consensuslpl_offOrthosteric Ligands1p_off lpa_off
22.73Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
22.73Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
22.73Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
22.58Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
22.58Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
22.58Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
22.58Consensusbombesin_onOrthosteric Ligandbb2_on
22.58Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
22.58Consensuscrf1_onOrthosteric Ligand6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF1-Corticoliberin-Gs/β1/γ2
22.58Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
22.22Single6DS0Ly2660976DS0-5-HT2B-Ly266097
22.22Single6JODAngiotensin II6JOD-AT2-Angiotensin II
22.22Single6ME9Ramelteon6ME9-MT2-Ramelteon
22.22Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
22.22Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
22.22Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
22.22Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
22.22Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
22.22Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
22.22Single7XRRLemborexant7XRR-OX2-Lemborexant
22.22Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
22.22Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
22.22Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
22.22Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
22.22Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.22Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
22.22Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
22.22Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
22.22Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
22.22Single8YYWAlpha-ketoglutarate8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
22.22Single8ZBISomatostatin-148ZBI-SST3-Somatostatin-14-Gi1/β1/γ2
22.22Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
22.22Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Single9K6LSA09K6L-TAS2R16-SA0-Gi2/β1/γ2
22.22Consensusangiotensin_offOrthosteric Ligandat1_off
22.22Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
22.22Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
22.22Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
22.22Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
22.22Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
22.22Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
22.22Consensuspth2_on_gpOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
22.22Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
22.22Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
22.22Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
22.22Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
22.22Consensusvasop-oxy_onOrthosteric Ligandv2_on
22.22Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
21.74Single6K1QIRL25006K1Q-ETB-IRL2500
21.74Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
21.74Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.74Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
21.74Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
21.74Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
21.74Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
21.74Single8T3OTUG-8918T3O-FFA4-TUG-891-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.74Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
21.74Single8XJOU466198XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Single8ZWGJR14a8ZWG-C3aB-JR14a-Gi1/β1/γ2
21.74Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
21.74Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
21.74Consensuschemerin_onOrthosteric Ligandcml1_on
21.74Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
21.74Consensusfp-alpha_onOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Consensusprostanoid_offOrthosteric Ligandep_off dp_off
21.74Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
21.74Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
21.74Consensustp_onOrthosteric Ligand8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Consensustp_on_gpOrthosteric Ligand8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
21.43Single8GEJConstrained Epinephrine8GEJ-β2-Constrained Epinephrine-Gs/β1/γ2
21.43Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
21.43Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
21.43Single8ZRTET-18ZRT-ETB-ET-1
21.43Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
21.43Consensusvpac1_onOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
21.21Consensuscrf1_on_gpOrthosteric Ligand6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF1-Corticoliberin-Gs/β1/γ2
21.21Consensuscrf_on_gpOrthosteric Ligandcrf2_on_gp crf1_on_gp
21.05Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
21.05Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
21.05Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
21.05Single6IQLL7458706IQL-D4-L745870
21.05Single6TPKRetosiban6TPK-OT-Retosiban
21.05Single6V9SGTPL114036V9S-OX1-GTPL11403
21.05Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
21.05Single7T32ZM-2413857T32-A2A-ZM-241385
21.05Single7VODCariprazine7VOD-5-HT2A-Cariprazine
21.05Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
21.05Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
21.05Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
21.05Single8IHKAcifran8IHK-HCA3-Acifran
21.05Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
21.05Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
21.05Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
21.05Single8K5CAcipimox8K5C-HCA2-Acipimox
21.05Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Gi1/β1/γ2
21.05Single9KPDSA09KPD-TAS2R16-SA0-chim(Gs-CtGt3)/β1/γ2
21.05Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
21.05Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
21.05Consensushca_onOrthosteric Ligandhca2_on
21.05Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
21.05Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
21.05Consensusvasop-oxy_offOrthosteric Ligandot_off
20.83Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
20.83Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
20.83Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
20.83Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
20.83Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
20.83Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
20.83Single9IPVJR14a9IPV-C3aB-JR14a-Gi1/β1/γ2
20.83Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Single9JH6C20:0 Ceramide9JH6-CysLT2-C20:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Single9M0RNeuropeptide VF9M0R-NPFF1-Neuropeptide VF-Gi1/β1/γ2
20.83Single9V2NMacimorelin9V2N-Ghrelin-Macimorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
20.83Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
20.83Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
20.69Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
20.69Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
20.69Single9BLBCagrilintide backbone (non-acylated)9BLB-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
20.69Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
20.69Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
20.69Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
20.69Consensusvpac1_on_gpOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
20.59Consensusclass-a_class-b1_cons_on_gpOrthosteric Ligandclass-a_on_gp class-b1_on_gp
20.59Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
20.00Single4YAYZD-71554YAY-AT1-ZD-7155
20.00Single5DHGC-355DHG-NOP-C-35
20.00Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
20.00Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
20.00Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
20.00Single6GPSMK08126GPS-CCR2-MK0812
20.00Single6IIVDaltroban6IIV-TXA2-Daltroban
20.00Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
20.00Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
20.00Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
20.00Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
20.00Single6XBM5LWE6XBM-SMO-5LWE-Gi1/β1/γ2
20.00Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
20.00Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
20.00Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
20.00Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
20.00Single7F83PF-051904577F83-Ghrelin-PF-05190457
20.00Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
20.00Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
20.00Single7V3ZCP559407V3Z-CB1-CP55940
20.00Single7WC4Serotonin7WC4-5-HT2A-Serotonin
20.00Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
20.00Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
20.00Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
20.00Single8CU6LJ-45178CU6-A2A-LJ-4517
20.00Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
20.00Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
20.00Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
20.00Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
20.00Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
20.00Single8IEBA1LYA8IEB-GPR156-A1LYA
20.00Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
20.00Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
20.00Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
20.00Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
20.00Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
20.00Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
20.00Single8K5DGSK2560738K5D-HCA2-GSK256073
20.00Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
20.00Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
20.00Single8ZBJSomatostatin-148ZBJ-SST5-Somatostatin-14-Gi1/β1/γ2
20.00Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
20.00Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
20.00Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
20.00Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
20.00Single9JGKBalovaptan9JGK-5-HT2B-Balovaptan
20.00Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
20.00Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
20.00Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
20.00Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
20.00Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
20.00Consensushca_on_gpOrthosteric Ligandhca2_on_gp
20.00Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
20.00Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
20.00Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
20.00Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
19.35Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
19.35Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
19.35Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
19.35Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
19.35Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
19.35Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
19.35Consensusbradykinin_onOrthosteric Ligandbk2_on
19.35Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
19.35Consensusendothelin_onOrthosteric Ligandetb_on eta_on
19.35Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
19.23Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
19.23Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
19.23Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
19.23Single9E82SDF-1-beta9E82-ACKR3-SDF-1-β-Arrestin2
19.23Single9IQVMuscarinic toxin 39IQV-Alpha1A-Muscarinic toxin 3
19.23Single9KFIRelaxin-39KFI-RXFP3-Relaxin-3-Gi2/β1/γ2
19.05Single4NTJAZD12834NTJ-P2Y12-AZD1283
19.05Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
19.05Single5N2RPSB-365N2R-A2A-PSB-36-Na
19.05Single5N2SPSB365N2S-A1-PSB36
19.05Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
19.05Single6D26Fevipiprant6D26-DP2-Fevipiprant
19.05Single6GPXMK08126GPX-CCR2-MK0812
19.05Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
19.05Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
19.05Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
19.05Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
19.05Single7W41PD1762527W41-BB2-PD176252
19.05Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
19.05Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
19.05Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
19.05Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
19.05Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
19.05Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
19.05Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
19.05Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
19.05Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
19.05Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
19.05Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
19.05Single8ZVZBW245C8ZVZ-DP1-BW245C-Gs/β1/γ2
19.05Single9B9ZA1AKO9B9Z-CB1-A1AKO
19.05Single9CIBFCH-22964139CIB-HCA2-FCH-2296413
19.05Single9EHSLUF76029EHS-A3A-LUF7602
19.05Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
19.05Single9GE2ML1849GE2-GPR55-ML184-chim(NtGi1-G13)/β1/γ2
19.05Single9KPFSA09KPF-TAS2R16-SA0-Gi1/β1/γ2
19.05Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
19.05Consensusadenosine_offOrthosteric Liganda1_off a2_off
19.05Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
19.05Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
19.05Consensusblt_offOrthosteric Ligandblt1_off
19.05Consensusbombesin_offOrthosteric Ligandbb2_off
19.05Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
19.05Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
19.05Consensusdp_offOrthosteric Liganddp2_off
19.05Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
19.05Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
18.75Single5GLHEndothelin-15GLH-ETB-Endothelin-1
18.75Single6IGKEndothelin-36IGK-ETB-Endothelin-3
18.75Single6TQ9SB-4081246TQ9-OX1-SB-408124
18.75Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
18.75Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
18.75Consensusclass-a_class-b1_cons_onOrthosteric Ligandclass-a_on class-b1_on
18.75Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
18.52Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
18.52Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.52Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
18.52Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
18.52Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
18.52Single9M1OMorphine-Modulating Neuropeptide B9M1O-NPFF2-Morphine-Modulating Neuropeptide B-Gi1/β1/γ2
18.52Single9U4WGonadoliberin-19U4W-GnRH1-Gonadoliberin-1-chim(NtGi1L-Gs-CtGq)/β1/γ2
18.18Single5TZRMK86665TZR-FFA1-MK8666
18.18Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
18.18Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
18.18Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
18.18Single7FEECP559407FEE-CB1-CP55940-ZCZ011
18.18Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
18.18Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
18.18Single7TUYGSK682753A7TUY-GPR183-GSK682753A
18.18Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
18.18Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
18.18Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
18.18Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
18.18Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
18.18Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
18.18Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
18.18Single8JD5JNJ-40411813; ADX881788JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
18.18Single8Y73Peptide8Y73-μ-Peptide-MPAM-15-Gi1/β1/γ2
18.18Single8ZW0PGD28ZW0-DP1-PGD2-Gs/β1/γ2
18.18Single8ZWFJR14a8ZWF-C3aB-JR14a
18.18Single9AUCCalcitonin gene-related peptide-19AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
18.18Single9EGOYVF9EGO-CB1-YVF-Gi1/β1/γ2
18.18Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
18.18Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
17.95Consensuspth_on_gpOrthosteric Ligandpth1_on_gp pth2_on_gp
17.86Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
17.86Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
17.86Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
17.86Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
17.86Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
17.86Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
17.86Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
17.86Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
17.86Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
17.86Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
17.86Single9BLCCagrilintide backbone (non-acylated)9BLC-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
17.86Single9BUDCagrilintide9BUD-CT-Cagrilintide-Gs/β1/γ2
17.86Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
17.86Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
17.86Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
17.65Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
17.65Single3UZAGTPL92363UZA-A2A-GTPL9236
17.65Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
17.65Single6ME5Agomelatine6ME5-MT1-Agomelatine
17.65Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
17.65Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
17.65Single7WC5Psilocin7WC5-5-HT2A-Psilocin
17.65Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
17.65Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
17.65Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
17.65Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
17.65Single9JHJC18:0 Ceramide9JHJ-FPR2-ALX-C18:0 Ceramide-Gi1/β1/γ2
17.65Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
17.65Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
17.65Consensusglp1_on_gpOrthosteric Ligand7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
17.65Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
17.65Consensuspth1_on_gpOrthosteric Ligand6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
17.39Single4N4WSANT-14N4W-SMO-SANT-1
17.39Single5X33BIIL2605X33-BLT1-BIIL260
17.39Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
17.39Single6IIURamatroban6IIU-TXA2-Ramatroban
17.39Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
17.39Single6KQICP559406KQI-CB1-CP55940-Org27569
17.39Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
17.39Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
17.39Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
17.39Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
17.39Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
17.39Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
17.39Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
17.39Single8Y6WTUG-13758Y6W-FFA2-TUG-1375-4-CMTB-Gi1/β1/γ2
17.39Single9AU0BW245C9AU0-DP1-BW245C-Gs/β1/γ2
17.39Single9CM3TUG-13759CM3-FFA2-TUG-1375-Compound 187-chim(NtGi1L-Gs-CtGq)/β1/γ2
17.39Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
17.39Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
17.39Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
17.39Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
17.39Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
17.39Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
17.24Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
17.24Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
17.24Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
17.24Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.24Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
17.24Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
17.24Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
17.24Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
17.24Consensuscalcitonin_onOrthosteric Ligandctlike_on
17.24Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
17.24Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
17.24Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
17.24Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
17.24Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
17.24Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
17.14Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
17.14Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
17.14Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
16.67Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
16.67Single6FJ3PTH6FJ3-PTH1-PTH
16.67Single6TP4ACT-4622066TP4-OX1-ACT-462206
16.67Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
16.67Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
16.67Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
16.67Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
16.67Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
16.67Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
16.67Single7XP6Strychnine7XP6-TAS2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
16.67Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
16.67Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
16.67Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
16.67Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
16.67Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
16.67Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
16.67Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
16.67Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
16.67Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
16.67Single9B9Y7DY9B9Y-CB1-7DY
16.67Single9BP3Cagrilintide9BP3-CT (AMY1)-Cagrilintide-Gs/β1/γ2; RAMP1
16.67Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
16.67Single9GG5U466199GG5-TXA2-U46619-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
16.67Single9IZDCHBA9IZD-HCA1-CHBA-Gi1/β1/γ2
16.67Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
16.67Single9M1HProstaglandin E29M1H-EP1-Prostaglandin E2-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Consensuscalcitonin_on_gpOrthosteric Ligandctlike_on_gp
16.67Consensuscrf2_on_gpOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
16.67Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Consensuspac1_onOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
16.67Consensuspac1_on_gpOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
16.67Consensuspth_onOrthosteric Ligandpth1_on pth2_on
16.67Consensussecretin_onOrthosteric Ligand7D3S-Secretin-Secretin-Gs/β1/γ2
16.13Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
16.13Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
16.13Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
16.13Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
16.13Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
16.13Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
16.13Consensussecretin_on_gpOrthosteric Ligand7D3S-Secretin-Secretin-Gs/β1/γ2
16.00Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
16.00Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
16.00Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
16.00Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
16.00Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
16.00Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
16.00Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
16.00Single8QJ2pN1628QJ2-MC4-pN162-Gs
16.00Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
16.00Single9CM7TUG-13759CM7-FFA2-TUG-1375-AZ-1729-Gi1/β1/γ2
16.00Single9IPYJR14a9IPY-C3aB-JR14a
16.00Single9IZASCH9002719IZA-HCA2-SCH900271-Gi1/β1/γ2
16.00Single9NS9TUG-13759NS9-FFA2-TUG-1375-Compound 187-Gi1/β1/γ2
16.00Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
16.00Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
16.00Consensuskisspeptin_onOrthosteric Ligandkiss1_on
15.79Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
15.79Single5U09Taranabant5U09-CB1-Taranabant
15.79Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
15.79Single7BR3Elagolix7BR3-GnRH1-Elagolix
15.79Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
15.79Single7F8ULintitript7F8U-CCKA-Lintitript
15.79Single7VVOPTH7VVO-PTH1-PTH-Gs/β1/γ2
15.79Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
15.79Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
15.79Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
15.79Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.79Single8GNGIstradefylline8GNG-A2A-Istradefylline
15.79Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
15.79Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
15.79Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
15.79Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
15.79Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
15.79Single9H2XA1IR19H2X-A2A-A1IR1-Na
15.79Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
15.62Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
15.62Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
15.62Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
15.62Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
15.62Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
15.62Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
15.62Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
15.62Single8IY6Endothelin-18IY6-ETB-Endothelin-1
15.62Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
15.62Single9BTWCagrilintide9BTW-CT (AMY3)-Cagrilintide-Gs/β1/γ2; RAMP3
15.62Consensusctlike_on_gpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
15.62Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
15.62Consensuspth1_onOrthosteric Ligand6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
15.38Single7F8XNN90567F8X-CCKA-NN9056
15.38Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
15.38Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
15.38Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
15.38Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
15.38Single8IEIA1LYA8IEI-GPR156-A1LYA
15.38Single8IEIA1LYA8IEI-GPR156-A1LYA
15.38Single8IEPA1LYA8IEP-GPR156-A1LYA
15.38Single8IEPA1LYA8IEP-GPR156-A1LYA
15.38Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
15.38Single8WKYPG-9348WKY-MC4-PG-934
15.38Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.38Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
15.38Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
15.38Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
15.38Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
15.38Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
15.38Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
15.38Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
15.38Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
15.38Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
15.15Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
15.00Single5IU7Q274563465IU7-A2A-Q27456346-Na
15.00Single5JTBZM-2413855JTB-A2A-ZM-241385
15.00Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
15.00Single6AQFZM-2413856AQF-A2A-ZM-241385
15.00Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
15.00Single6MH8ZM-2413856MH8-A2A-ZM-241385
15.00Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
15.00Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
15.00Single7AROLUF58337ARO-A2A-LUF5833-Na
15.00Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
15.00Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
15.00Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
15.00Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
15.00Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.00Single8K9LDamgo8K9L-μ-Damgo-BMS-986122-Gi3/β1/γ1
15.00Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
15.00Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
15.00Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
15.00Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
15.00Single8Y6YGLPG09748Y6Y-FFA2-GLPG0974
15.00Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
15.00Single8ZPMAMD0708ZPM-CXCR4-AMD070
15.00Single8ZPNAMD31008ZPN-CXCR4-AMD3100
15.00Single9BA0A1AKN9BA0-CB1-A1AKN
15.00Single9JMDAzithromycin9JMD-Motilin-Azithromycin-chim(Gs-CtGq)/β1/γ2
15.00Single9M2FNeuropeptide FF9M2F-NPFF1-Neuropeptide FF-Gi1/β1/γ2
15.00Consensusa2_offOrthosteric Liganda2a_off
15.00Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
15.00Consensusgrh_offOrthosteric Ligandgnrh1_off
14.81Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
14.81Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
14.81Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
14.81Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
14.81Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
14.81Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
14.81Single8IEBA1LYA8IEB-GPR156-A1LYA
14.81Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
14.81Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
14.81Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
14.81Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
14.81Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
14.81Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
14.81Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
14.71Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
14.71Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
14.71Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
14.71Consensusglp1_onOrthosteric Ligand7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
14.71Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
14.71Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
14.29Single3EMLZM-2413853EML-A2A-ZM-241385
14.29Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
14.29Single5IU8Q274563475IU8-A2A-Q27456347-Na
14.29Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
14.29Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
14.29Single5UENDU1725UEN-A1-DU172
14.29Single5UIGCmpd-15UIG-A2A-Cmpd-1
14.29Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
14.29Single6D27CAY104716D27-DP2-CAY10471
14.29Single6S0LZM-2413856S0L-A2A-ZM-241385
14.29Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
14.29Single6W25SHU91196W25-MC4-SHU9119-Ca
14.29Single7PYRPSB-21157PYR-A2A-PSB-2115
14.29Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
14.29Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
14.29Single7YXAONO-54306087YXA-S1P5-ONO-5430608
14.29Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
14.29Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
14.29Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
14.29Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
14.29Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
14.29Single8W8YGamma-MSH8W8Y-MC3-γ-MSH-Ca-Gs/β1/γ2
14.29Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
14.29Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
14.29Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
14.29Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
14.29Single9H37A1IR09H37-A2A-A1IR0-Na
14.29Single9IYAONO-97105319IYA-GPR55-ONO-9710531
14.29Single9IZCMK19039IZC-HCA2-MK1903-Gi1/β1/γ2
14.29Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
14.29Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
14.29Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
14.29Consensusclass-b1_class-b2_cons_onOrthosteric Ligandclass-b1_on class-b2_on
14.29Consensusclass-b1_class-b2_cons_on_gpOrthosteric Ligandclass-b1_on_gp class-b2_on_gp
14.29Consensusclass-b1_on_gpOrthosteric Ligandglucagon_on_gp vip-pacap_on_gp pth_on_gp crf_on_gp calcitonin_on_gp
14.29Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
14.29Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
14.29Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
14.29Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
14.29Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
13.89Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
13.79Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
13.79Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
13.79Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
13.79Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
13.79Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
13.79Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
13.79Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
13.79Single9EBOGLP-1 (ACPC18)9EBO-GLP-1-GLP-1 (ACPC18)-Gs/β1/γ2
13.79Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
13.79Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
13.79Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
13.79Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
13.64Single5IUAQ274563485IUA-A2A-Q27456348-Na
13.64Single5T1ABMS-6815T1A-CCR2-BMS-681-PubChem 12093170
13.64Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
13.64Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
13.64Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
13.64Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
13.64Single6S0QZM-2413856S0Q-A2A-ZM-241385
13.64Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
13.64Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
13.64Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
13.64Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
13.64Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
13.64Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
13.64Single8GNEKW-63568GNE-A2A-KW-6356-Na
13.64Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
13.64Single8QOTNanobody-E8QOT-μ-Nanobody-E
13.64Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
13.64Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
13.64Consensusep_offOrthosteric Ligandep4_off
13.64Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
13.64Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
13.64Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
13.64Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
13.64Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
13.51Consensusgluc_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
13.33Single5MZPCaffeine5MZP-A2A-Caffeine-Na
13.33Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
13.33Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
13.33Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
13.33Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
13.33Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
13.33Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
13.33Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
13.33Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
13.33Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
13.33Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
13.33Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
13.33Single9JFYhNPSF9JFY-NPFF2-hNPSF-Gi1/β1/γ2
13.16Consensusgluc_on_gpOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
13.16Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
13.16Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
13.04Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
13.04Single7PX4PSB-21137PX4-A2A-PSB-2113
13.04Single7T9NDPPC7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
13.04Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
13.04Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
13.04Single8GDBPGE28GDB-EP4-PGE2-Gs/β1/γ2
13.04Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
13.04Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
13.04Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
13.04Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Gi1/β1/γ1
13.04Single9CLWTUG-13759CLW-FFA2-TUG-1375-4-CMTB-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.04Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
13.04Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
13.04Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
13.04Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
13.04Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
13.04Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
13.04Consensuslpa_onOrthosteric Ligandlpa1_on
13.04Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
13.04Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
13.04Consensusrelaxin_onOrthosteric Ligandrxfp4_on
13.04Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
12.90Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
12.90Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
12.90Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
12.90Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
12.90Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
12.90Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
12.90Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
12.90Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
12.90Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
12.90Single9BUBCagrilintide9BUB-CT-Cagrilintide-Gs/β1/γ2
12.90Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
12.90Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
12.90Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
12.90Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
12.90Consensuspac_on_gpOrthosteric Ligandpac1_on_gp
12.82Consensusclass-b1_onOrthosteric Ligandglucagon_on vip-pacap_on pth_on crf_on calcitonin_on
12.50Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
12.50Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
12.50Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
12.50Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
12.50Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
12.50Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
12.50Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
12.50Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
12.50Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
12.50Single8PWNTheophylline8PWN-A2A-Theophylline
12.50Single8W8WAlpha-MSH8W8W-MC3-α-MSH-Ca-Gs/β1/γ2
12.50Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
12.50Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
12.50Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
12.50Single9BJKNAM9BJK-μ-Naloxone-NAM
12.50Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
12.50Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
12.50Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
12.50Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
12.50Consensusglp2_on_gpOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
12.50Consensusglp_onOrthosteric Ligandglp1_on glp2_on
12.50Consensusglp_on_gpOrthosteric Ligandglp1_on_gp glp2_on_gp
12.50Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
12.50Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
12.12Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
12.12Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
12.12Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
12.12Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
12.12Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
12.12Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
12.12Single9BQ3Cagrilintide9BQ3-CT (AMY2)-Cagrilintide-Gs/β1/γ2; RAMP2
12.12Single9BYOExendin-39BYO-GLP-1-Exendin-3-Gs/β1/γ2
12.12Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
12.12Consensusvip-pacap_onOrthosteric Ligandvpac_on pac_on
12.12Consensusvip-pacap_on_gpOrthosteric Ligandvpac_on_gp pac_on_gp
12.12Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
12.12Consensusvpac2_on_gpOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
12.00Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
12.00Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
12.00Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
12.00Single9C0KExendin-49C0K-GLP-1-Exendin-4-Gs/β1/γ2
12.00Single9JH5C16:0 Ceramide9JH5-CysLT2-C16:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
12.00Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
12.00Consensuscck_onOrthosteric Ligandccka_on cckb_on
12.00Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
11.76Single3OE8IT1t3OE8-CXCR4-IT1t
11.76Single3RFMCaffeine3RFM-A2A-Caffeine
11.76Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
11.76Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
11.76Single8A2OTheophylline8A2O-A2A-Theophylline-Na
11.76Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
11.76Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
11.76Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
11.76Consensusgip_onOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
11.76Consensusgip_on_gpOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
11.76Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
11.76Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
11.54Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
11.54Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
11.54Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
11.54Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
11.54Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
11.54Single9JF4PD1683689JF4-BB1-PD168368
11.54Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
11.36Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
11.11Single3OE6IT1t3OE6-CXCR4-IT1t
11.11Single4XT1Fractalkine4XT1-US28-Fractalkine
11.11Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
11.11Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
11.11Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
11.11Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
11.11Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
11.11Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
11.11Single8KIGSHU91198KIG-MC3-SHU9119-Ca
11.11Single8U4OCXCL128U4O-CXCR4-CXCL12-Gi1/β1/γ2
11.11Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
11.11Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
11.11Single8YWFRetatrutide8YWF-GLP-1-Retatrutide-chim(NtGi1-Gs)/β1/γ2
11.11Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single9HB3Mambaquaretin-19HB3-V2-Mambaquaretin-1
11.11Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
11.11Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
10.81Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
10.81Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
10.81Consensusglucagon_onOrthosteric Ligandglp_on gluc_on secretin_on gip_on
10.71Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
10.71Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
10.71Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
10.71Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
10.71Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
10.71Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
10.71Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
10.71Single9IQRMuscarinic toxin 39IQR-α2a-Muscarinic toxin 3
10.71Single9IQSMuscarinic toxin 39IQS-M4-Muscarinic toxin 3
10.71Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
10.71Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
10.71Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
10.71Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
10.53Single3OE9IT1t3OE9-CXCR4-IT1t
10.53Single5L7IVismodegib5L7I-SMO-Vismodegib
10.53Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
10.53Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
10.53Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
10.53Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab
10.53Single8YKDDehydroepiandrosterone8YKD-ADGRG2-Dehydroepiandrosterone-chim(NtGi1-Gs)/β1/γ2
10.53Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
10.53Consensusglucagon_on_gpOrthosteric Ligandglp_on_gp gluc_on_gp secretin_on_gp gip_on_gp
10.34Single3OE0CVX153OE0-CXCR4-CVX15
10.34Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
10.34Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
10.34Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
10.34Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
10.34Single9B5YLong-Acting PTH9B5Y-PTH1-Long-Acting PTH-chim(NtGi1-Gq)/β1/γ2
10.34Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
10.34Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
10.34Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
10.34Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
10.34Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
10.00Single3ODUIT1t3ODU-CXCR4-IT1t
10.00Single3PWHZM-2413853PWH-A2A-ZM-241385
10.00Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
10.00Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
10.00Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
10.00Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
10.00Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
10.00Single5ZKQABT-4915ZKQ-PAF-ABT-491
10.00Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
10.00Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
10.00Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
10.00Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
10.00Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
10.00Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
10.00Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
10.00Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
10.00Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
10.00Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
10.00Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
10.00Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
10.00Single8T3VDocosa-4,7,10,13,16,19-Hexaenoic acid8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.00Single8U4PAMD31008U4P-CXCR4-AMD3100-Gi1/β1/γ2
10.00Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
10.00Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ2
10.00Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
10.00Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
10.00Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
9.68Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
9.68Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
9.68Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
9.68Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
9.68Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
9.68Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
9.68Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
9.68Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
9.68Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
9.68Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
9.68Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
9.68Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
9.68Consensuspac_onOrthosteric Ligandpac1_on
9.68Consensusvpac_onOrthosteric Ligandvpac1_on vpac2_on
9.52Single3REYXAC3REY-A2A-XAC
9.52Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
9.52Single5IUBQ274563445IUB-A2A-Q27456344-Na
9.52Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
9.52Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
9.52Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
9.52Single5UVIZM-2413855UVI-A2A-ZM-241385
9.52Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
9.52Single7UTZDPPC7UTZ-TSH-TR1402-DPPC-Gs/β1/γ2
9.52Single8IYXYL-3658IYX-GPR34-YL-365
9.52Single8K2WAMG4878K2W-CXCR3-AMG487
9.52Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
9.52Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
9.52Single9IXXLTD49IXX-CysLT2-LTD4-chim(NtGi1-Gs-CtGq)/β1/γ2
9.52Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
9.52Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
9.38Single4XT3Fractalkine4XT3-US28-Fractalkine
9.38Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
9.38Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
9.38Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
9.38Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
9.38Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
9.38Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
9.38Consensusvpac_on_gpOrthosteric Ligandvpac1_on_gp vpac2_on_gp
9.09Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
9.09Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
9.09Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
9.09Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
9.09Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
9.09Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
9.09Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
9.09Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
9.09Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
9.09Single8W8XBeta-MSH8W8X-MC3-β-MSH-Ca-Gs/β1/γ2
9.09Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
9.09Consensuscck_offOrthosteric Ligandccka_off
9.09Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
8.82Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
8.70Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
8.70Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
8.70Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.70Single8WGBVU01550418WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
8.70Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
8.70Consensusadgrg2_onOrthosteric Ligand7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
8.70Consensusadgrg2_on_gpOrthosteric Ligand7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
8.70Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
8.57Single7RBTTirzepatide7RBT-GIP-Tirzepatide-LSN3556672-chim(NtGi1-Gs)/β1/γ2
8.33Single7R0CAVP7R0C-V2-AVP-Arrestin2
8.33Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
8.33Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
8.33Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
8.33Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
8.33Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
8.33Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
8.33Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
8.33Single9UY3Anamorelin9UY3-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
8.33Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
8.33Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
8.11Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
8.11Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
8.11Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
8.00Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
8.00Single4PY02MeSATP4PY0-P2Y12-2MeSATP
8.00Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
8.00Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
8.00Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
8.00Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
8.00Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
8.00Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
8.00Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
8.00Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
8.00Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
8.00Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
7.89Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
7.69Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
7.69Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
7.69Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
7.69Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
7.69Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
7.69Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
7.69Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
7.69Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
7.69Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
7.69Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
7.69Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
7.69Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
7.41Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
7.41Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
7.41Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
7.41Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
7.41Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
7.41Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
7.41Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
7.41Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
7.41Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
7.41Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
7.41Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
7.41Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
7.41Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
7.14Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
7.14Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
7.14Single9BUECagrilintide9BUE-CT-Cagrilintide-Gs/β1/γ2
7.14Single9J0IUDP-Glucuronic acid9J0I-P2Y14-UDP-Glucuronic acid-Gi1/β1/γ2
7.14Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
7.14Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14Consensussomatostatin_offOrthosteric Ligandsst2_off
6.90Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
6.90Single7SK5CXCL127SK5-ACKR3-CXCL12
6.90Single7XNACYN1548067XNA-SST2-CYN154806
6.90Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
6.90Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
6.90Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
6.90Single9J0FNADH9J0F-P2Y14-NADH-Gi1/β1/γ2
6.90Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
6.90Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
6.67Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
6.67Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
6.67Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
6.67Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
6.67Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
6.67Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
6.67Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
6.67Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
6.45Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
6.45Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
6.45Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
6.45Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
6.25Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
6.25Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
6.25Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
6.06Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
6.06Single7SK3CXCL127SK3-ACKR3-CXCL12
6.06Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
5.88Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
5.88Single7V68LY21196207V68-M4-Iperoxo-LY2119620-Gi1/β1/γ2
5.88Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
5.88Single8X9S5alpha-DHT8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
5.56Single8IKGQ2B8IKG-CB1-Q2B-Gi1/β1/γ1
5.41Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
5.26Single6OBAGTPL110746OBA-β2-S-Alprenolol-GTPL11074
5.26Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/β1/γ2
5.26Single8J6QCompound 9n8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
5.26Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
5.13Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
5.00Single6LI0C176LI0-GPR52-C17
5.00Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
5.00Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
5.00Single8IKHQ2L8IKH-CB1-Q2L-Gi1/β1/γ1
5.00Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
5.00Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/β1/γ2
5.00Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
5.00Single8K9LBMS-9861228K9L-μ-Damgo-BMS-986122-Gi3/β1/γ1
5.00Single9LMPNE52-QQ579LMP-GPR4-NE52-QQ57
4.76Single4K5YCP-3763954K5Y-CRF1-CP-376395
4.76Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
4.76Single6C1QNDT95137276C1Q-C5a1-PMX53-NDT9513727
4.76Single7F8YDevazepide7F8Y-CCKA-Devazepide
4.76Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.76Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
4.76Single7WV9ZCZ0117WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
4.76Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
4.76Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
4.76Single8Y72BMS-9861228Y72-μ-Peptide-BMS-986122-Gi1/β1/γ2
4.76Single9JCOLPC9JCO-GPR4-LPC-chim(NtGi1-Gs)/β1/γ2
4.76Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
4.55Single5O9HNDT95137275O9H-C5a1-NDT9513727
4.55Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
4.55Single7T94LY21196207T94-M2-Acetylcholine-LY2119620-chim(NtGi1-Go)/β1/γ2
4.55Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
4.55Single8JD6VU03647708JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
4.55Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55Single9JFUNE52-QQ579JFU-GPR4-NE52-QQ57
4.55Single9K0KUTP9K0K-P2Y4-UTP-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55Single9K0XATP9K0X-P2Y2-ATP-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55Single9K20ATP9K20-P2Y2-ATP-chim(NtGi1-Go)/β1/γ2
4.55Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
4.55Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
4.35Single4QIMANTA XV4QIM-SMO-ANTA XV
4.35Single4Z9GCP-3763954Z9G-CRF1-CP-376395
4.35Single6C1RAvacopan; Na6C1R-C5a1-PMX53-Avacopan; Na
4.35Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
4.35Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
4.35Single8GTIBMK-C2058GTI-CRF1-BMK-C205
4.35Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
4.35Single8Y73MPAM-158Y73-μ-Peptide-MPAM-15-Gi1/β1/γ2
4.35Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
4.17Single4JKVTaladegib4JKV-SMO-Taladegib
4.17Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
4.17Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
4.17Single8GTGBMK-I1528GTG-CRF1-BMK-I152
4.17Single8YYXLeukotriene e48YYX-Oxoglutarate-Leukotriene e4-chim(Gi1-CtGq)/β1/γ2
4.17Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00Single5V56TC1145V56-SMO-TC114
4.00Single5V57TC1145V57-SMO-TC114
4.00Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
4.00Single6OS1TRV0266OS1-AT1-TRV026
4.00Single7F1TMIP-1a7F1T-CCR5-MIP-1a
4.00Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
4.00Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00Single8JD5JNJ-40411813; ADX881788JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
4.00Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
3.85Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
3.85Single6OS2TRV0266OS2-AT1-TRV026
3.85Single8GTMBMK-C2038GTM-CRF1-BMK-C203
3.70Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
3.70Single8XVUCXCL28XVU-CXCR2-CXCL2
3.70Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
3.70Single8ZPLHF511168ZPL-CXCR4-HF51116
3.57Single6KNMJN241-96KNM-Apelin-JN241-9
3.57Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.57Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
3.57Single8XQJJN2418XQJ-Apelin-JN241
3.57Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
3.57Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
3.45Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
3.45Single8XWNCXCL88XWN-CXCR2-CXCL8
3.33Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
3.33Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
3.33Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
3.23Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
3.23Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
3.23Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
3.23Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
3.03Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
2.94Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2

Consensus Members
Id Members
8HN8 8HN8-H4-Histamine-Gi1/β1/γ2
8HOC 8HOC-H4-Imetit-Gi1/β1/γ2
8JXV 8JXV-H4-Clozapine-Gi1/β1/γ2
8JXW 8JXW-H4-VUF6884-Gi1/β1/γ2
8JXX 8JXX-H4-Clobenpropit-Gi1/β1/γ2
Net Summary
Imin 2.224
Number of Linked Nodes 886
Number of Links 1116
Number of Hubs 192
Number of Links mediated by Hubs 706
Number of Communities 27
Number of Nodes involved in Communities 270
Number of Links involved in Communities 401
Path Summary
Number Of Nodes in MetaPath 133
Number Of Links MetaPath 132
Number of Shortest Paths 2628973
Length Of Smallest Path 3
Average Path Length 33.6009
Length of Longest Path 63
Minimum Path Strength 0.376667
Average Path Strength 4.52359
Maximum Path Strength 20.333
Minimum Path Correlation 0.7
Average Path Correlation 0.969311
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.72414
Average % Of Corr. Nodes 31.1018
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 53.8151
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following consensuses:
IdComponents
histamine_on_gph1_on_gp
h2_on_gp
h3_on_gp
h4_on_gp



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Download h4_on_gp.zip



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