Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
1G.HN.34 2.0095404
2G.HN.37 3.592403
3G.HN.43 3.1064539
4G.hns1.01 7.214163
5G.S1.02 5.226486
6G.S1.06 5.2584178
7G.H1.03 1.731409
8G.S3.03 6.5388588
9G.S3.04 7.4145427
10G.S3.06 7.6828526
11G.S3.07 4.02554179
12G.s3h2.03 4.5328529
13G.H2.03 6.081429
14G.H2.06 5.19933629
15G.H2.07 5.3124529
16G.H2.10 3.8412528
17G.h2s4.01 7.51529
18G.S4.04 3.9964549
19G.H3.01 4.25085189
20G.H3.06 4.6625406
21G.H3.09 4.6188549
22G.H3.13 7.755646
23G.H3.17 8.112625
24G.S5.05 4.081336129
25G.S5.06 3.198449
26G.S5.07 3.834409
27G.s5hg.01 5.21454199
28G.HG.01 5.1952546
29G.HG.03 3.3134197
30G.hgh4.05 10.3035406
31G.hgh4.08 7.737407
32G.hgh4.11 4.7635404
33G.hgh4.20 6.277403
34G.hgh4.21 5.789404
35G.H4.03 3.0985404
36G.H4.07 7.6145445
37G.H4.08 5.5944543
38G.H4.10 9.398406
39G.H4.12 5.383445
40G.H4.15 5.8852548
41G.h4s6.02 4.1645408
42G.h4s6.08 2.7105444
43G.h4s6.12 4.1045402
44G.h4s6.20 5.378494
45G.S6.02 7.2856598
46G.S6.05 6.4845445
47G.s6h5.01 6.20654129
48G.s6h5.05 5.65054129
49G.H5.03 5.54285129
50G.H5.05 5.737486
51G.H5.06 5.59454124
52G.H5.08 4.95914789
53G.H5.12 3.2125487
54G.H5.13 7.7575498
55G.H5.17 7.15067696
56G.H5.25 3.913409
57b.1x7 3.3215408
58b.h2x1 3.818405
59b.lhb1x3 3.1304502
60b.lhb1x6 4.1088553
61b.lhb1x9 3.5435403
62b.lhb1x11 4.313454
63b.b1x6 7.8855439
64b.l1x3 7.12467639
65b.l1x6 9.2944529
66b.b2x1 6.0296528
67b.b2x5 6.14133637
68b.b3x3 3.63854118
69b.l3x1 8.1415429
70b.l3x2 6.94054169
71b.b4x2 4.723408
72b.b4x3 3.9454117
73b.b4x5 3.8184117
74b.b4x6 7.1045839
75b.l4x2 10.443434
76b.b5x2 5.9035407
77b.b5x3 6.76667639
78b.b5x7 5.3407
79b.l5x1 4.06565118
80b.l5x5 8.607629
81b.b6x1 4.692429
82b.b6x5 3.6968116
83b.l6x5 5.25254154
84b.b7x1 4.65325154
85b.l7x2 3.7285429
86b.b8x4 5.30285116
87b.l9x3 6.6428529
88b.l9x6 4.75175828
89b.b10x5 4.6196509
90b.l10x1 3.8745403
91b.l11x2 6.018529
92b.b12x6 7.94267628
93b.b13x7 6.7567
94b.l13x3 7.04167669
95b.l13x6 5.26529
96b.l13x7 4.0592569
97b.b14x3 3.775465
98b.b15x1 5.96333669
99b.l15x1 5.4465427
100b.l15x2 5.8085469
101b.b16x4 9.011466
102b.b16x5 3.658405
103b.b16x6 8.28767668
104b.b17x5 6.6145427
105b.b17x7 7.8415428
106b.l17x3 8.09429729
107b.l17x6 7.302529
108b.b18x3 4.3775428
109b.b18x5 4.9505405
110b.l18x1 6.3098106
111b.l18x2 6.30254107
112b.b19x2 6.7472526
113b.b19x4 6.646428
114b.l19x1 6.3135429
115b.l19x2 7.5688529
116b.b20x2 6.628426
117b.b20x4 8.68267628
118b.b20x6 5.75771726
119b.b20x7 5.371409
120b.l20x2 7.5075409
121b.b21x1 7.5108527
122b.b21x5 5.2075404
123b.b21x7 6.108505
124b.l21x2 5.302404
125b.b22x5 5.2016107
126b.l22x5 7.158559
127b.b23x6 7.076336137
128b.l23x1 6.244526
129b.b24x4 7.85454136
130b.b24x6 7.4174138
131b.l24x3 4.9265405
132b.b25x3 7.7444135
133b.l25x3 7.6488559
134b.l25x6 12.3844528
135b.l27x1 10.6591729
136b.l27x2 7.0655459
137b.b28x3 4.2512537
138b.b28x4 7.4365456
139b.b28x6 8.0716559
140g.h1x11 3.35409
141g.h1x12 1.9805406
142g.l1x4 6.471428
143g.h2x9 1.8955404
144g.h2x11 8.1024106
145g.ctx3 6.1196559
146g.ctx6 2.91433656
147g.ctx14 5.9105439
148g.ctx15 7.401439
149g.ctx16 4.609838
150NT.P110 2.688406
151NT.W112 5.1675417
152NT.D113 5.00067619
153NT.I115 5.907415
154NT.L116 5.0516515
155NT.W118 7.759619
156NT.V129 3.942415
157NT.P132 5.445419
158NT.Y134 5.503415
159NT.I135 6.0828517
160NT.Y136 5.8405414
161NT.F138 7.27514
162NT.R146 9.028518
163NT.V157 3.491414
164NT.W164 5.5732515
165NT.Y167 5.77867615
1661x39 3.5435415
1671x43 4.938517
1681x47 5.36371717
1691x54 4.081409
1701x64 4.916607
1712x45 4.43554227
1722x46 5.8928509
1732x54 3.4648509
1742x57 6.328718
1752x58 3.3805408
1762x60 7.147618
1772x71 3.969405
1783x30 8.2775408
1793x36 5.3092517
1803x37 4.5652517
1813x38 4.65733679
1823x39 7.9475405
1833x40 5.5655416
1843x44 7.21767617
1853x45 4.85576
1863x46 9.152679
1873x47 3.128419
1883x48 4.5332508
1893x50 8.354409
1903x53 6.39165228
1913x55 7.976498
1923x58 4.3295498
1933x59 7.055496
194I2.F314 3.50933687
1954x39 3.1645226
1964x50 8.265479
1974x52 3.1325474
1984x53 3.3092579
1994x60 5.697618
2004x64 7.3555418
201E2x51 10.912518
202E2x52 4.893415
2035x37 7.8855417
2045x38 5.932408
2055x54 7.27325149
2065x64 6.2145499
2075x65 3.9134208
2086x49 6.694676149
2096x52 8.7412518
2106x53 10.4433618
2116x56 6.80567617
2126x57 3.3195406
2137x34 7.40867615
2147x37 8.0865416
2157x40 6.9452514
2167x41 5.8412517
2177x45 7.306516
2187x47 4.477417
2197x49 5.865419
2208x60 1.692407
221Lig 11.45074810
222G.H1.11 1.7785400
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1b.l2x5 b.l4x2 13.476721.606NoYes054
2b.l4x2 g.ctx15 13.45211.13YesYes349
3b.l26x5 g.ctx15 20.4897.044NoYes059
4b.l26x5 g.ctx4 24.71854.358NoNo057
5g.ctx3 g.ctx4 25.30654.83YesNo097
6g.ctx3 g.ctx5 24.52732.986YesNo599
7b.lhb1x11 g.ctx5 24.86735.372YesNo549
8b.b28x6 b.lhb1x11 46.99643.026YesYes594
9b.b27x3 b.b28x6 24.16588.248NoYes089
10b.b27x3 b.l25x3 75.87466.848NoYes089
11b.l25x3 b.l27x2 99.4045.544YesYes599
12b.l25x4 b.l27x2 99.75663.192NoYes059
13I1x49 b.l25x4 99.879313.578NoNo075
148x53 I1x49 99.88998.374NoNo097
151x64 8x53 99.900411.426YesNo079
161x60 1x64 1002.51NoYes087
171x60 7x58 99.66722.946NoNo089
181x57 7x58 99.6763.61NoNo099
191x57 2x54 99.68492.77NoYes099
201x54 2x54 25.59025.846YesYes099
211x54 2x57 25.65383.654YesYes098
22b.b28x4 b.b28x6 23.6165.336YesYes569
23b.b28x4 b.l25x3 23.73379.694YesYes569
242x54 7x53 25.12092.358YesNo099
252x57 7x53 25.09762.358YesNo089
261x61 2x54 49.31142.682NoYes079
271x61 2x47 49.14694.12NoNo079
282x46 2x47 49.04316.03YesNo099
292x46 G.H5.23 48.93529.88YesNo094
30G.H5.23 G.H5.25 32.85863.516NoYes049
315x61 G.H5.25 33.65034.706NoYes089
325x61 G.H5.20 33.56443.598NoNo088
333x58 G.H5.20 32.55985.138YesNo088
343x58 G.H5.16 16.6154.39YesNo086
355x64 G.H5.16 16.46667.594YesNo096
365x64 G.H5.13 33.25546.362YesYes998
37G.H5.13 G.S6.02 32.132110.114YesYes988
38G.H5.10 G.S6.02 62.582111.262NoYes078
39G.H5.10 G.S5.03 29.57429.796NoNo079
40G.S5.03 G.S5.05 28.4333.518NoYes099
41G.S4.03 G.S5.05 19.38372.762NoYes089
423x58 5x60 15.9562.766YesNo988
435x60 5x64 51.46842.734NoYes989
443x54 G.H5.23 16.0819.848NoNo094
453x54 5x57 26.20353.998NoNo099
463x55 5x57 26.10813.18YesNo089
473x55 3x59 36.046411.312YesYes986
483x59 5x60 35.71833.668YesNo968
495x64 G.H5.17 34.40038.168YesYes996
50G.H5.17 G.S6.02 32.13732.882YesYes968
51G.H5.10 G.S6.04 32.440411.598NoNo079
52G.S5.05 G.S6.04 28.43194.982YesNo099
53G.S1.06 G.S4.03 13.69012.85YesNo088
54G.S3.06 b.l5x5 11.204915.434YesYes269
55G.S1.05 G.h2s4.01 17.108316.564NoYes099
56G.S4.07 G.s5hg.01 10.19816.816NoYes089
57G.S5.07 G.s5hg.01 15.93915.318YesYes099
58G.S5.07 G.s6h5.01 31.81374.388YesYes099
59G.S5.05 G.s6h5.01 32.95126.746YesYes1299
60G.H2.06 b.l17x6 11.94417.188YesYes299
61G.H2.06 b.l9x6 24.18873.58YesYes298
62b.b2x1 b.l27x1 52.42727.716YesYes289
63G.H2.10 b.b2x1 19.34924.032YesYes288
64b.l25x6 b.l27x1 55.8820.59YesYes289
65b.l17x5 b.l17x6 12.01795.302NoYes269
66b.b19x6 b.l17x5 23.53352.608NoNo296
67b.b19x6 b.l17x3 21.519310.6NoYes299
68b.b20x6 b.l17x3 17.27763.168YesYes269
69b.b17x7 b.b20x6 13.95029.858YesYes286
70b.b17x7 b.b21x1 10.82794.538YesYes287
71G.H2.06 b.l19x1 11.8353.594YesYes299
72b.l17x5 b.l19x1 11.73495.3NoYes269
73b.l22x5 b.lhb1x3 10.22334.76YesYes092
74b.h2x1 b.h2x5 16.73713.244YesNo055
75b.b21x5 b.h2x1 11.79786.218YesYes045
76b.l22x5 b.l24x2 13.68047.774YesNo096
77b.lhb1x11 b.lhb1x9 22.06612.92YesYes043
78b.lhb1x6 b.lhb1x9 21.15083.686YesYes033
79b.b22x1 b.l25x6 56.22475.95NoYes288
80b.b26x3 b.b27x3 53.33183.536NoNo068
81b.b22x2 b.b26x3 56.92424.806NoNo086
822x57 3x43 40.770516.914YesNo088
832x60 3x43 37.807811.33YesNo088
842x60 Lig 33.96527.21YesYes180
85Lig NT.W164 10.69413.742YesYes105
866x53 7x49 11.91547.44YesYes189
873x48 5x50 12.18724.12YesNo089
883x47 5x50 25.27073.116YesNo099
893x48 3x52 10.71174.428YesNo085
905x50 6x49 13.078610.872NoYes099
913x52 5x53 10.54873.046NoNo057
92G.H1.03 G.s6h5.03 11.29942.238YesNo099
93G.S5.07 G.s6h5.03 12.44771.788YesNo099
94b.b22x1 b.b22x2 56.86932.88NoNo088
95b.b2x1 b.b6x1 29.84595.986YesYes289
96b.b6x1 b.l9x6 29.74975.028YesYes298
97G.H2.10 G.h2s4.01 16.13283.072YesYes289
98b.l22x5 b.lhb1x6 19.09646.28YesYes593
993x47 7x49 15.63162.742YesYes199
1003x55 5x53 10.38918.486YesNo087
1013x54 6x49 10.32783.412NoYes099
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
LigNT.V317.1241YesNo0001
NT.E36NT.M325.6840NoNo0021
NT.M32NT.Y1365.031NoYes0011
LigNT.M323.4741YesNo0001
NT.E35NT.T336.491NoNo0011
NT.E36NT.T337.620NoNo0021
LigNT.K349.2161YesNo0001
NT.I135NT.Q373.841YesNo0011
NT.L40NT.Y1343.2820NoYes0022
NT.H114NT.W1122.751NoYes0012
NT.D113NT.I1155.321YesYes0011
NT.D113NT.L1163.5281YesYes0012
NT.D113NT.W1187.8161YesYes0012
NT.D113NT.Y1675.7481YesYes0011
LigNT.D1134.4741YesYes0001
LigNT.H1147.211YesNo0001
NT.I115NT.L1163.141YesYes0012
NT.I115NT.Y1675.561YesYes0011
LigNT.I1159.6081YesYes0001
NT.L116NT.W1189.341YesYes0022
NT.L116NT.P1326.5681YesYes0022
NT.W118NT.Y1673.8581YesYes0021
NT.P132NT.Y1346.9541YesYes0022
NT.I135NT.P1325.081YesYes0012
NT.F138NT.P1323.1781YesYes0012
NT.I135NT.Y1344.8361YesYes0012
NT.F138NT.I13513.5641YesYes0011
LigNT.I1353.0941YesYes0001
NT.D137NT.Y1364.141NoYes0011
LigNT.Y1369.9021YesYes0001
LigNT.D13720.631YesNo0001
NT.C170NT.F1385.5840NoYes0021
NT.F138NT.V1714.981YesNo0011
LigNT.F1389.0441YesYes0001
NT.A144NT.Y1673.2040NoYes0021
NT.E155NT.R14711.8641NoNo0022
NT.R147NT.W16412.9961NoYes0021
NT.E155NT.W1644.7961NoYes0021
NT.V157NT.W1642.9421YesYes0021
NT.N166NT.W1643.390NoYes0021
NT.A165NT.Y1674.5380NoYes0021
LigNT.Y16711.7641YesYes0001
LigNT.V1714.081YesNo0001
1x301x333.6220NoNo2221
1x32E3.V4324.2781NoNo6011
1x32Lig6.6341NoYes6010
1x331x376.4321NoNo2412
1x33Lig5.1741NoYes2010
1x367x344.0081NoYes5611
1x36Lig17.8681NoYes5010
1x397x383.3921YesNo7611
1x397x394.6281YesNo7512
1x397x423.111YesNo7911
1x39Lig3.0441YesYes7010
1x431x474.7661YesYes7721
1x432x642.6621YesNo7522
1x437x425.7481YesNo7921
1x472x609.6721YesYes7711
1x472x613.7341YesNo7812
1x472x647.4941YesNo7512
1x472x652.6781YesNo7412
1x477x463.8161YesNo7912
1x47Lig5.3861YesYes7010
2x603x406.81YesYes7711
2x603x4311.331YesNo7912
2x603x444.7341YesYes7811
2x607x453.1361YesYes7911
2x60Lig7.211YesYes7010
2x643x363.5181NoYes5621
2x672x713.6661NoYes0012
2x67Lig3.4261NoYes0010
2x71E2x525.1560YesYes0521
3x363x374.8721YesYes6611
3x363x403.6561YesYes6711
3x36Lig7.0561YesYes6010
3x374x606.6061YesYes6812
3x375x395.711YesNo6412
3x403x445.1581YesYes7811
3x40Lig6.6481YesYes7010
3x445x4310.8821YesNo8711
3x446x5315.6861YesYes8512
3x44Lig3.71YesYes8010
4x605x398.4561YesNo8422
E2x50E2x523.4260NoYes9521
E2x52Lig8.0061YesYes5010
E2.L354Lig6.3141NoYes0010
5x37E2.S3553.6721YesNo0011
E2.S355Lig9.5381NoYes0010
5x375x388.5841YesYes0612
5x37E3.Y42914.571YesNo0011
5x37Lig4.7161YesYes0010
5x385x407.230YesNo6321
5x40E3.Y4296.5381NoNo3011
5x40Lig16.5081NoYes3010
5x43Lig3.9941NoYes7010
5x476x535.081NoYes7522
6x526x5318.2941YesYes6522
6x527x403.9221YesYes6522
6x527x456.3761YesYes6921
6x537x4513.261YesYes5921
6x566x595.1881YesNo0022
6x567x3714.991YesYes0721
6x567x407.221YesYes0522
6x567x413.7341YesYes0621
6x597x378.5061NoYes0721
E3.Y429Lig23.591NoYes0010
7x34E3.T4303.3961YesNo6012
E3.V432Lig4.681NoYes0010
7x347x352.8521YesNo6512
7x347x3814.891YesNo6611
7x34Lig12.931YesYes6010
7x377x412.81YesYes7611
7x37Lig6.051YesYes7010
7x38Lig14.4321NoYes6010
7x407x414.7141YesYes5621
7x417x458.4161YesYes6911
7x41Lig9.5421YesYes6010
7x42Lig10.6961NoYes9010
7x45Lig5.3421YesYes9010
3x37Lig3.2541YesYes6010
2x72Lig16.8321NoYes0010
LigNT.T336.8861YesNo0001
LigNT.E352.9341YesNo0001
LigNT.Q376.891YesNo0001
LigNT.I383.421YesNo0001
LigNT.L413.3621YesNo0001
NT.V31NT.Y1364.291NoYes0011
NT.E35NT.K343.511NoNo0011
NT.L40NT.Q373.460NoNo0021
NT.D113NT.E1113.1181YesNo0012
2x673x367.4441NoYes0611
2x712x725.8620YesNo0021
3x445x473.1461YesNo8712
E2.L354E2x522.9841NoYes0511
7x34E3.V4326.3761YesNo6011
LigNT.W1643.7421YesYes0001
NT.H114NT.L413.61NoNo0011
1x26NT.V1712.3840NoNo3021
3x333x372.3840NoYes7621
1x32E3.S4332.0121NoNo6012
1x29Lig1.0820NoYes3010
1x27Lig1.0340NoYes3010

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
88.89Consensuspth1_onOrthosteric Ligand6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
63.33Consensuspac1_onOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
63.33Consensuspac1_on_gpOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
61.29Consensussecretin_on_gpOrthosteric Ligand7D3S-Secretin-Secretin-Gs/β1/γ2
58.06Consensussecretin_onOrthosteric Ligand7D3S-Secretin-Secretin-Gs/β1/γ2
58.06Consensusvpac1_on_gpOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
56.76Consensuspth2_on_gpOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
54.84Consensusvpac1_onOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
54.55Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
54.55Consensusvpac2_on_gpOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
54.29Consensusglp1_on_gpOrthosteric Ligand7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
52.94Consensusgip_onOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
52.94Consensusgip_on_gpOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
52.78Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
51.52Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
51.52Consensusglp2_on_gpOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
51.43Consensusglp1_onOrthosteric Ligand7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
46.15Consensusgluc_on_gpOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
45.71Consensusctlike_on_gpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
43.59Consensusgluc_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
42.42Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
42.11Consensuscrf1_on_gpOrthosteric Ligand6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF1-Corticoliberin-Gs/β1/γ2
40.54Single7RBTTirzepatide7RBT-GIP-Tirzepatide-LSN3556672-chim(NtGi1-Gs)/β1/γ2
40.54Consensuscrf1_onOrthosteric Ligand6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF1-Corticoliberin-Gs/β1/γ2
40.00Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
40.00Consensuscrf2_on_gpOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
40.00Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
38.89Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
38.24Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ2
37.84Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
37.14Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
37.14Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
37.14Consensuspac_onOrthosteric Ligandpac1_on
36.36Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
36.11Single6FJ3PTH6FJ3-PTH1-PTH
36.11Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
36.11Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
36.11Consensuspac_on_gpOrthosteric Ligandpac1_on_gp
35.90Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
35.90Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
35.14Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
35.14Single9BUCCagrilintide9BUC-CT-Cagrilintide-Gs/β1/γ2
34.29Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
34.29Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
34.29Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
34.29Single9BLCCagrilintide backbone (non-acylated)9BLC-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
34.29Single9EBOGLP-1 (ACPC18)9EBO-GLP-1-GLP-1 (ACPC18)-Gs/β1/γ2
34.21Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
34.21Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
34.21Single9BYOExendin-39BYO-GLP-1-Exendin-3-Gs/β1/γ2
34.21Consensusvip-pacap_onOrthosteric Ligandvpac_on pac_on
34.21Consensusvip-pacap_on_gpOrthosteric Ligandvpac_on_gp pac_on_gp
34.15Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
34.09Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
33.33Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
33.33Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
33.33Consensuscalcitonin_onOrthosteric Ligandctlike_on
32.50Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
32.43Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
32.43Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
32.43Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
32.43Single9BLBCagrilintide backbone (non-acylated)9BLB-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
32.43Single9BLWCagrilintide backbone (non-acylated)9BLW-CT (AMY1)-Cagrilintide backbone (non-acylated)-Gs/β1/γ2; RAMP1
32.43Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
32.43Consensuscalcitonin_on_gpOrthosteric Ligandctlike_on_gp
32.43Consensusvpac_on_gpOrthosteric Ligandvpac1_on_gp vpac2_on_gp
31.71Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
31.71Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
31.71Consensuscrf_on_gpOrthosteric Ligandcrf2_on_gp crf1_on_gp
31.58Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
31.58Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
31.58Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
31.58Consensusglp_onOrthosteric Ligandglp1_on glp2_on
31.58Consensusglp_on_gpOrthosteric Ligandglp1_on_gp glp2_on_gp
30.95Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
30.95Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
30.95Consensusclass-a_class-b1_cons_on_gpOrthosteric Ligandclass-a_on_gp class-b1_on_gp
30.95Consensusglucagon_onOrthosteric Ligandglp_on gluc_on secretin_on gip_on
30.77Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
30.77Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
30.77Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
30.77Single9BQ3Cagrilintide9BQ3-CT (AMY2)-Cagrilintide-Gs/β1/γ2; RAMP2
30.77Single9BTWCagrilintide9BTW-CT (AMY3)-Cagrilintide-Gs/β1/γ2; RAMP3
30.56Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
30.56Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
30.56Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
30.56Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
30.56Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
30.56Single8ZBISomatostatin-148ZBI-SST3-Somatostatin-14-Gi1/β1/γ2
30.56Single9BUDCagrilintide9BUD-CT-Cagrilintide-Gs/β1/γ2
30.56Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
30.43Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
30.43Consensuspth_on_gpOrthosteric Ligandpth1_on_gp pth2_on_gp
30.30Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
30.23Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
30.23Consensusglucagon_on_gpOrthosteric Ligandglp_on_gp gluc_on_gp secretin_on_gp gip_on_gp
30.00Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
30.00Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
30.00Consensusclass-a_class-b1_cons_onOrthosteric Ligandclass-a_on class-b1_on
29.73Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
29.73Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
29.73Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
29.73Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
29.73Consensusvpac_onOrthosteric Ligandvpac1_on vpac2_on
29.41Single8YWFRetatrutide8YWF-GLP-1-Retatrutide-chim(NtGi1-Gs)/β1/γ2
29.41Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
29.27Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
29.27Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
29.27Single9AUCCalcitonin gene-related peptide-19AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
29.17Consensusclass-b1_on_gpOrthosteric Ligandglucagon_on_gp vip-pacap_on_gp pth_on_gp crf_on_gp calcitonin_on_gp
29.03Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
29.03Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
28.95Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
28.95Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
28.95Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
28.95Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
28.95Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
28.95Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
28.95Single9BP3Cagrilintide9BP3-CT (AMY1)-Cagrilintide-Gs/β1/γ2; RAMP1
28.95Single9BUBCagrilintide9BUB-CT-Cagrilintide-Gs/β1/γ2
28.95Single9KFKRelaxin-39KFK-RXFP4-Relaxin-3-Gi2/β1/γ2
28.95Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
28.89Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
28.89Consensusclass-b1_onOrthosteric Ligandglucagon_on vip-pacap_on pth_on crf_on calcitonin_on
28.57Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
28.57Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
28.57Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
28.57Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
28.57Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
28.57Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
28.21Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
28.21Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
28.21Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
28.21Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
28.21Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
28.21Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
28.12Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
28.12Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
28.12Single9EBIPiclidenoson9EBI-A3A-Piclidenoson-chim(NtGi1L-Gs-CtGi1)/β1/γ2
27.91Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
27.91Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
27.91Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
27.78Single5WF5UK-4320975WF5-A2A-UK-432097
27.78Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
27.78Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
27.78Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
27.78Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
27.78Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
27.78Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
27.78Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
27.50Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
27.50Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
27.50Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
27.50Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
27.50Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
27.50Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
27.27Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
27.27Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
27.27Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
27.27Single9C0KExendin-49C0K-GLP-1-Exendin-4-Gs/β1/γ2
27.27Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
27.27Consensuspth_onOrthosteric Ligandpth1_on pth2_on
27.03Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
27.03Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
27.03Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
27.03Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
27.03Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
27.03Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
26.83Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
26.83Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
26.83Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
26.83Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
26.67Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
26.47Single4UG2CGS216804UG2-A2A-CGS21680
26.47Single5WF6UK-4320975WF6-A2A-UK-432097
26.47Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
26.47Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
26.32Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
26.32Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
26.32Single9JFYhNPSF9JFY-NPFF2-hNPSF-Gi1/β1/γ2
26.32Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
26.32Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
26.19Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
25.81Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
25.81Single7LD3Adenosine7LD3-A1-Adenosine-MIPS521-Gi2/β1/γ2
25.81Single8XYKVUF106618XYK-CXCR3-VUF10661-Go/β1/γ2
25.81Consensusa3_on_gpOrthosteric Liganda3a_on_gp
25.81Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
25.81Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
25.71Single7QA8Peptide7QA8-STE2-Peptide
25.71Single7QA8Peptide7QA8-STE2-Peptide
25.71Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
25.71Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
25.71Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
25.71Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
25.71Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
25.64Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
25.64Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
25.58Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
25.00Single3QAKUK-4320973QAK-A2A-UK-432097
25.00Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
25.00Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
25.00Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
25.00Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
25.00Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
25.00Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
25.00Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
25.00Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
25.00Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
25.00Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
25.00Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
25.00Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
25.00Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
25.00Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
25.00Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
25.00Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
25.00Consensusa2_onOrthosteric Liganda2b_on
25.00Consensusa2_on_gpOrthosteric Liganda2b_on_gp
25.00Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
25.00Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
25.00Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
25.00Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
25.00Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
25.00Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
25.00Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
25.00Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
25.00Consensusrelaxin_onOrthosteric Ligandrxfp4_on
25.00Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
25.00Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
25.00Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
24.39Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
24.39Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
24.39Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
24.39Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
24.39Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
24.39Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
24.39Consensusbradykinin_onOrthosteric Ligandbk2_on
24.39Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
24.39Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
24.32Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
24.32Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
24.32Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
24.32Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
24.32Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
24.32Single9B5YLong-Acting PTH9B5Y-PTH1-Long-Acting PTH-chim(NtGi1-Gq)/β1/γ2
24.32Consensusangiotensin_onOrthosteric Ligandat1_on
24.32Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
24.32Consensusclass-b1_class-b2_cons_onOrthosteric Ligandclass-b1_on class-b2_on
24.32Consensusclass-b1_class-b2_cons_on_gpOrthosteric Ligandclass-b1_on_gp class-b2_on_gp
24.24Single8XYIVUF106618XYI-CXCR3-VUF10661
24.24Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
23.68Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
23.68Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
23.68Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
23.68Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
23.68Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
23.68Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
23.68Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
23.68Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
23.68Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
23.68Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
23.53Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
23.53Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
23.53Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
23.53Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
23.33Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
23.33Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
23.08Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
23.08Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
23.08Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
23.08Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
23.08Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
23.08Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
23.08Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
23.08Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
23.08Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
23.08Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
23.08Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
23.08Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
22.86Single3NY9ICI118-5513NY9-β2-ICI118-551
22.86Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
22.86Single7SK9CCX6627SK9-ACKR3-CCX662
22.86Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
22.86Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
22.86Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
22.86Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
22.86Single9M0RNeuropeptide VF9M0R-NPFF1-Neuropeptide VF-Gi1/β1/γ2
22.86Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
22.86Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
22.86Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
22.73Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
22.58Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
22.58Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
22.58Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
22.58Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
22.58Consensusa3_onOrthosteric Liganda3a_on
22.58Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
22.58Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
22.58Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
22.50Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
22.50Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
22.50Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
22.50Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
22.50Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
22.22Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
22.22Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
22.22Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
22.22Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
22.22Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
22.22Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
22.22Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
22.22Single8WDTphotoNECA8WDT-A2A-photoNECA
22.22Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
22.22Single9BUECagrilintide9BUE-CT-Cagrilintide-Gs/β1/γ2
22.22Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
22.22Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
22.22Consensuslpl_onOrthosteric Ligands1p_on lpa_on
22.22Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
22.22Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
21.95Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
21.95Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
21.95Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
21.95Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
21.95Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
21.95Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
21.95Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
21.95Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
21.95Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
21.88Single5C1MBU725C1M-μ-BU72
21.88Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
21.88Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
21.88Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
21.88Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
21.88Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
21.88Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
21.88Single9EE8Adenosine9EE8-A2A-Adenosine-Gs/β1/γ2
21.88Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
21.88Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
21.88Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
21.88Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
21.88Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
21.62Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
21.62Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
21.62Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
21.62Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
21.62Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
21.62Single9E82SDF-1-beta9E82-ACKR3-SDF-1-β-Arrestin2
21.62Single9IK8SST analogue9IK8-SST1-SST analogue-Gi1/β1/γ2
21.62Single9IQVMuscarinic toxin 39IQV-Alpha1A-Muscarinic toxin 3
21.62Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
21.43Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
21.43Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
21.43Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
21.28Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
21.28Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
21.21Single2YDVNECA2YDV-A2A-NECA
21.21Single4UHRCGS216804UHR-A2A-CGS21680
21.21Single5G53NECA5G53-A2A-NECA-Gs
21.21Single5V54Methiothepin5V54-5-HT1B-Methiothepin
21.21Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
21.21Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
21.21Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
21.21Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
21.21Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
21.21Single8E0GBU728E0G-μ-BU72
21.21Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
21.21Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
21.21Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
21.21Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
21.21Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
21.21Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
21.21Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
21.21Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
21.21Single9IK9SST analogue9IK9-SST1-SST analogue-Gi1/β1/γ2
21.21Consensus5ht1_offOrthosteric Ligand5ht1b_off
21.21Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
21.21Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
21.21Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
21.21Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
21.21Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
21.05Single6PT2KGCHM076PT2-δ-KGCHM07
21.05Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.05Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
21.05Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
21.05Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
21.05Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
21.05Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
21.05Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
21.05Single9U4WGonadoliberin-19U4W-GnRH1-Gonadoliberin-1-chim(NtGi1L-Gs-CtGq)/β1/γ2
21.05Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
21.05Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
21.05Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
21.05Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
21.05Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
21.05Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
20.93Single5GLHEndothelin-15GLH-ETB-Endothelin-1
20.93Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
20.69Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
20.69Single8K5BNiacin8K5B-HCA2-Niacin
20.69Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
20.59Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
20.59Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
20.59Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
20.59Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
20.59Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
20.59Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
20.59Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
20.59Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
20.59Single7YITNalfurafine7YIT-κ-Nalfurafine
20.59Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
20.59Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
20.59Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
20.59Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
20.59Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
20.59Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
20.59Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
20.59Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
20.51Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
20.51Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
20.51Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
20.51Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
20.51Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
20.51Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
20.51Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
20.51Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
20.51Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
20.51Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
20.51Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
20.51Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
20.51Consensusvasop-oxy_onOrthosteric Ligandv2_on
20.51Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
20.45Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
20.45Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
20.00Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
20.00Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
20.00Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
20.00Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
20.00Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
20.00Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
20.00Single7EZCUKA7EZC-A2A-UKA
20.00Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
20.00Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
20.00Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
20.00Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
20.00Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
20.00Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
20.00Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
20.00Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
20.00Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
20.00Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
20.00Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
20.00Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
20.00Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
20.00Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
20.00Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
20.00Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
20.00Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
20.00Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
20.00Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
20.00Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
20.00Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
20.00Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
20.00Single8XVUCXCL28XVU-CXCR2-CXCL2
20.00Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
20.00Single9EBHAdenosine9EBH-A3A-Adenosine-Gi1/β1/γ2
20.00Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
20.00Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
20.00Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
20.00Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
20.00Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
19.51Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
19.51Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
19.51Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
19.51Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
19.51Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
19.51Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
19.51Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
19.44Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
19.44Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
19.44Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
19.44Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
19.44Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
19.44Single7XN9L-054,5227XN9-SST2-L-054,522
19.44Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
19.44Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
19.44Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
19.44Single8QJ2pN1628QJ2-MC4-pN162-Gs
19.44Single9IZASCH9002719IZA-HCA2-SCH900271-Gi1/β1/γ2
19.44Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
19.44Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
19.44Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
19.44Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
19.44Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
19.44Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
19.35Single2YDOAdenosine2YDO-A2A-Adenosine
19.35Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
19.35Single5IU7Q274563465IU7-A2A-Q27456346-Na
19.35Single5IUBQ274563445IUB-A2A-Q27456344-Na
19.35Single5JTBZM-2413855JTB-A2A-ZM-241385
19.35Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
19.35Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
19.35Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
19.35Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
19.35Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
19.35Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
19.35Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
19.35Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
19.35Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
19.35Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.35Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
19.35Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
19.35Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
19.35Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
19.35Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
19.35Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
19.35Single8K5CAcipimox8K5C-HCA2-Acipimox
19.35Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
19.35Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
19.35Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
19.35Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.35Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
19.35Consensusa2_offOrthosteric Liganda2a_off
19.35Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
19.35Consensushca_onOrthosteric Ligandhca2_on
19.05Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
19.05Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
19.05Single8W8XBeta-MSH8W8X-MC3-β-MSH-Ca-Gs/β1/γ2
19.05Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
18.92Single4IARErgotamine4IAR-5-HT1B-Ergotamine
18.92Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
18.92Single4XT1Fractalkine4XT1-US28-Fractalkine
18.92Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
18.92Single7F8XNN90567F8X-CCKA-NN9056
18.92Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
18.92Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
18.92Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
18.92Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
18.92Single8U4OCXCL128U4O-CXCR4-CXCL12-Gi1/β1/γ2
18.92Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
18.92Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
18.92Single9BUYLM1899BUY-β2-LM189-Gi1/β1/γ2
18.92Single9HB3Mambaquaretin-19HB3-V2-Mambaquaretin-1
18.92Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
18.92Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
18.92Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
18.87Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
18.75Single3EMLZM-2413853EML-A2A-ZM-241385
18.75Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
18.75Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
18.75Single5IU8Q274563475IU8-A2A-Q27456347-Na
18.75Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
18.75Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
18.75Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
18.75Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
18.75Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
18.75Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
18.75Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
18.75Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
18.75Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
18.75Single6S0LZM-2413856S0L-A2A-ZM-241385
18.75Single6TOTLemborexant6TOT-OX1-Lemborexant
18.75Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.75Single6XBM5LWE6XBM-SMO-5LWE-Gi1/β1/γ2
18.75Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
18.75Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
18.75Single7PYRPSB-21157PYR-A2A-PSB-2115
18.75Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
18.75Single7UL4Alvimopan7UL4-μ-Alvimopan
18.75Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
18.75Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
18.75Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
18.75Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
18.75Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
18.75Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
18.75Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
18.75Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
18.75Single8T1WCVN4248T1W-GPR6-CVN424
18.75Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
18.75Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
18.75Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
18.75Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
18.75Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
18.75Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
18.75Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
18.75Single9H37A1IR09H37-A2A-A1IR0-Na
18.75Single9IVGGLP-1 (Truncated)9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
18.75Single9KFJPubChem 1383196749KFJ-RXFP3-PubChem 138319674-Gi2/β1/γ2
18.75Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
18.75Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
18.75Consensusblt_onOrthosteric Ligandblt1_on
18.75Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
18.75Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
18.75Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
18.75Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
18.75Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
18.75Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
18.75Consensushca_on_gpOrthosteric Ligandhca2_on_gp
18.75Consensusleukotriene_onOrthosteric Ligandblt_on
18.75Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
18.60Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
18.42Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
18.42Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
18.42Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
18.42Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
18.42Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
18.42Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
18.42Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
18.42Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
18.42Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
18.42Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
18.42Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
18.42Single9IQSMuscarinic toxin 39IQS-M4-Muscarinic toxin 3
18.42Single9KFIRelaxin-39KFI-RXFP3-Relaxin-3-Gi2/β1/γ2
18.42Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
18.42Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
18.42Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
18.42Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
18.42Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
18.42Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
18.18Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
18.18Single5IUAQ274563485IUA-A2A-Q27456348-Na
18.18Single5N2RPSB-365N2R-A2A-PSB-36-Na
18.18Single5N2SPSB365N2S-A1-PSB36
18.18Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
18.18Single5X7DS-Carazolol5X7D-β2-S-Carazolol-Cmpd-15
18.18Single6IGKEndothelin-36IGK-ETB-Endothelin-3
18.18Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
18.18Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
18.18Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
18.18Single6S0QZM-2413856S0Q-A2A-ZM-241385
18.18Single6TP6Filorexant6TP6-OX1-Filorexant
18.18Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
18.18Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
18.18Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
18.18Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
18.18Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
18.18Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
18.18Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.18Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
18.18Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
18.18Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
18.18Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
18.18Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
18.18Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
18.18Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
18.18Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
18.18Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
18.18Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
18.18Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
18.18Single8GNEKW-63568GNE-A2A-KW-6356-Na
18.18Single8TF5Oleic acid8TF5-GPR6-Oleic acid
18.18Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
18.18Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
18.18Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
18.18Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
18.18Single8WGBVU01550418WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
18.18Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
18.18Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
18.18Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
18.18Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
18.18Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
18.18Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
18.18Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Single9CIBFCH-22964139CIB-HCA2-FCH-2296413
18.18Single9DYDAsenapine9DYD-5-HT1A-Asenapine-Go/β1/γ2
18.18Single9DYFAsenapine9DYF-5-HT1A-Asenapine-Gi1/β1/γ2
18.18Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
18.18Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
18.18Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
18.18Consensusadenosine_offOrthosteric Liganda1_off a2_off
18.18Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
18.18Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
18.18Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
18.18Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
18.18Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
18.18Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
18.18Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
18.18Consensustrace-amine_onOrthosteric Ligandta1_on
17.95Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
17.95Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
17.95Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
17.95Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
17.95Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
17.95Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
17.95Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
17.95Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
17.95Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
17.86Single9EE9Adenosine9EE9-A2A-Adenosine-Gs/β1/γ2
17.78Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
17.65Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
17.65Single4U15Tiotropium4U15-M3-Tiotropium
17.65Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
17.65Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
17.65Single6J21Aprepitant6J21-NK1-Aprepitant
17.65Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
17.65Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
17.65Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
17.65Single6OL9Tiotropium6OL9-M5-Tiotropium
17.65Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
17.65Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
17.65Single7P2L4YI7P2L-mGlu5-4YI
17.65Single7PX4PSB-21137PX4-A2A-PSB-2113
17.65Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
17.65Single7T9NDPPC7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
17.65Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
17.65Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
17.65Single7TUYGSK682753A7TUY-GPR183-GSK682753A
17.65Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
17.65Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
17.65Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
17.65Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
17.65Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
17.65Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
17.65Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
17.65Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
17.65Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
17.65Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
17.65Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
17.65Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
17.65Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
17.65Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
17.65Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
17.65Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
17.65Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
17.65Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
17.65Single8Y73Peptide8Y73-μ-Peptide-MPAM-15-Gi1/β1/γ2
17.65Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
17.65Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
17.65Single9BJKNaloxone9BJK-μ-Naloxone-NAM
17.65Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
17.65Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
17.65Single9JMCDS-3801b9JMC-Motilin-DS-3801b-chim(Gs-CtGq)/β1/γ2
17.65Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
17.65Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
17.65Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
17.65Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
17.65Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
17.65Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
17.65Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
17.65Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
17.65Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
17.65Consensuslpa_onOrthosteric Ligandlpa1_on
17.65Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
17.65Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
17.65Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
17.65Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
17.65Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
17.50Single6JODAngiotensin II6JOD-AT2-Angiotensin II
17.50Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
17.50Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
17.50Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
17.50Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
17.50Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
17.50Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
17.39Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
17.24Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
17.24Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
17.14Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
17.14Single3D4STimolol3D4S-β2-Timolol
17.14Single4N4WSANT-14N4W-SMO-SANT-1
17.14Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
17.14Single4RWADIPP-NH24RWA-δ-DIPP-NH2
17.14Single5CXVTiotropium5CXV-M1-Tiotropium
17.14Single6A93Risperidone6A93-5-HT2A-Risperidone
17.14Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
17.14Single6OS2TRV0266OS2-AT1-TRV026
17.14Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
17.14Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
17.14Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
17.14Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
17.14Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
17.14Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
17.14Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
17.14Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
17.14Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
17.14Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
17.14Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
17.14Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
17.14Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
17.14Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
17.14Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
17.14Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
17.14Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
17.14Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
17.14Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
17.14Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
17.14Single8JJ8Formoterol8JJ8-β2-Formoterol
17.14Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
17.14Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
17.14Single8XWMCXCL68XWM-CXCR2-CXCL6
17.14Single9DGIZ85267113509DGI-CB1-Z8526711350
17.14Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
17.14Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
17.14Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
17.14Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
17.14Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
17.14Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
17.14Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
17.14Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
17.14Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
17.14Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
17.14Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
17.14Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
17.14Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
17.14Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
17.14Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
17.14Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
17.14Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
17.14Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
17.14Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
17.14Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
17.14Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
17.14Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
17.14Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
17.07Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
17.07Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
17.07Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
17.07Single8ZRTET-18ZRT-ETB-ET-1
17.07Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
17.07Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
17.07Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
17.07Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
16.67Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
16.67Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
16.67Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
16.67Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
16.67Single4XT3Fractalkine4XT3-US28-Fractalkine
16.67Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
16.67Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
16.67Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
16.67Single6LI0C176LI0-GPR52-C17
16.67Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
16.67Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
16.67Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
16.67Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
16.67Single7UM4AS26747237UM4-5-HT5A-AS2674723
16.67Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
16.67Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
16.67Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
16.67Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
16.67Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
16.67Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
16.67Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
16.67Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
16.67Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
16.67Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
16.67Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
16.67Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
16.67Single8S2TIsoprenaline8S2T-β1-Isoprenaline-chim(NtGi1-Gs)/β1/γ2
16.67Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
16.67Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
16.67Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
16.67Single8XWFCXCL38XWF-CXCR2-CXCL3
16.67Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
16.67Single8ZWGJR14a8ZWG-C3aB-JR14a-Gi1/β1/γ2
16.67Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
16.67Single9DYEBuspirone9DYE-5-HT1A-Buspirone-Go/β1/γ2
16.67Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
16.67Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
16.67Single9M54Neuropeptide VF9M54-NPFF2-Neuropeptide VF-Gi1/β1/γ2
16.67Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
16.67Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg4_on
16.67Consensusadgrg_on_gpOrthosteric Ligandadgrg2_on_gp adgrg4_on_gp
16.67Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
16.67Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
16.67Consensuscck_onOrthosteric Ligandccka_on cckb_on
16.67Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
16.67Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
16.67Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
16.67Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
16.67Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
16.67Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
16.67Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
16.28Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
16.28Single8W8WAlpha-MSH8W8W-MC3-α-MSH-Ca-Gs/β1/γ2
16.28Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
16.28Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
16.22Single5ZTYAM102575ZTY-CB2-AM10257
16.22Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
16.22Single6PT3DPI-2876PT3-δ-DPI-287
16.22Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
16.22Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
16.22Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
16.22Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
16.22Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
16.22Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
16.22Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
16.22Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
16.22Single8X5YAstemizole8X5Y-H1-Astemizole
16.22Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
16.22Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
16.22Single8Y72Peptide8Y72-μ-Peptide-BMS-986122-Gi1/β1/γ2
16.22Single9CGKC5-Quino9CGK-δ-C5-Quino-Gi1/β1/γ2
16.22Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
16.22Single9IPVJR14a9IPV-C3aB-JR14a-Gi1/β1/γ2
16.22Single9IPYJR14a9IPY-C3aB-JR14a
16.22Single9MD1Buspirone9MD1-5-HT1A-Buspirone-Gz/β1/γ2
16.22Single9V2NMacimorelin9V2N-Ghrelin-Macimorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
16.22Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
16.22Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
16.22Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
16.22Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
16.13Single3PWHZM-2413853PWH-A2A-ZM-241385
16.13Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
16.13Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
16.13Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
16.13Single5U09Taranabant5U09-CB1-Taranabant
16.13Single5ZKQABT-4915ZKQ-PAF-ABT-491
16.13Single6AKXA4R6AKX-CCR5-A4R
16.13Single6AKYMaraviroc6AKY-CCR5-Maraviroc
16.13Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
16.13Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
16.13Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
16.13Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
16.13Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
16.13Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
16.13Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
16.13Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
16.13Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.13Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
16.13Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
16.13Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
16.13Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
16.13Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
16.13Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
16.13Single8IWESpermidine8IWE-TA9-Spermidine
16.13Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
16.13Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
16.13Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
16.13Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
16.13Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.13Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
16.13Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
16.13Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
16.13Single8Y0HVUF114188Y0H-CXCR3-VUF11418
16.13Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go/β1/γ2
16.13Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
16.13Single9EEAAdenosine9EEA-A2A-Adenosine-Gs/β1/γ2
16.13Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
16.13Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
16.13Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
16.13Consensusangiotensin_offOrthosteric Ligandat1_off
16.13Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
16.13Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
16.13Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
16.13Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
16.13Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
15.91Single6IGLIRL16206IGL-ETB-IRL1620
15.91Consensusendothelin_onOrthosteric Ligandetb_on eta_on
15.79Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
15.79Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
15.79Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
15.79Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
15.79Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
15.79Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
15.79Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
15.79Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
15.79Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
15.79Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
15.79Single8PKMBefiradol8PKM-5-HT1A-Befiradol-Gi1/β1/γ1
15.79Single8XWNCXCL88XWN-CXCR2-CXCL8
15.79Single8ZBJSomatostatin-148ZBJ-SST5-Somatostatin-14-Gi1/β1/γ2
15.79Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
15.79Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
15.79Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
15.79Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
15.79Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
15.79Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
15.79Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
15.79Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
15.79Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
15.79Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
15.62Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
15.62Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
15.62Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
15.62Single4MBSMaraviroc4MBS-CCR5-Maraviroc
15.62Single4ZJCSB-6740424ZJC-OX1-SB-674042
15.62Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
15.62Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
15.62Single5UVIZM-2413855UVI-A2A-ZM-241385
15.62Single6AQFZM-2413856AQF-A2A-ZM-241385
15.62Single6FFIMMPEP6FFI-mGlu5-MMPEP
15.62Single6MH8ZM-2413856MH8-A2A-ZM-241385
15.62Single6PS0S-Carazolol6PS0-β2-S-Carazolol
15.62Single6PS4ICI118-5516PS4-β2-ICI118-551
15.62Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
15.62Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
15.62Single6TPGEMPA6TPG-OX2-EMPA
15.62Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
15.62Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
15.62Single7AROLUF58337ARO-A2A-LUF5833-Na
15.62Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
15.62Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
15.62Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
15.62Single7T32ZM-2413857T32-A2A-ZM-241385
15.62Single7T94LY21196207T94-M2-Acetylcholine-LY2119620-chim(NtGi1-Go)/β1/γ2
15.62Single7UL3Famotidine7UL3-H2-Famotidine
15.62Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
15.62Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
15.62Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
15.62Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
15.62Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
15.62Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
15.62Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
15.62Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
15.62Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
15.62Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
15.62Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.62Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
15.62Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
15.62Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
15.62Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
15.62Single8IHKAcifran8IHK-HCA3-Acifran
15.62Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
15.62Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
15.62Single8K2WAMG4878K2W-CXCR3-AMG487
15.62Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
15.62Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
15.62Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.62Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.62Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
15.62Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
15.62Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
15.62Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
15.62Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
15.62Single8ZPMAMD0708ZPM-CXCR4-AMD070
15.62Single8ZPNAMD31008ZPN-CXCR4-AMD3100
15.62Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
15.62Single9JH3CMF-0199JH3-Apelin-CMF-019-Gi1/β1/γ2
15.62Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
15.62Single9K0KUTP9K0K-P2Y4-UTP-chim(NtGi1-Gs-CtGq)/β1/γ2
15.62Single9K0XATP9K0X-P2Y2-ATP-chim(NtGi1-Gs-CtGq)/β1/γ2
15.62Single9K20ATP9K20-P2Y2-ATP-chim(NtGi1-Go)/β1/γ2
15.62Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
15.62Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
15.62Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
15.62Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
15.62Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
15.56Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
15.56Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
15.56Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
15.56Consensusbombesin_onOrthosteric Ligandbb2_on
15.56Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
15.56Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
15.56Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
15.38Single6HLOAprepitant6HLO-NK1-Aprepitant
15.38Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
15.38Single7SK5CXCL127SK5-ACKR3-CXCL12
15.38Single7XNACYN1548067XNA-SST2-CYN154806
15.38Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
15.38Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
15.38Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
15.38Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
15.38Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
15.22Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
15.22Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
15.15Single2Y04Salbutamol2Y04-β1-Salbutamol
15.15Single3NY8ICI118-5513NY8-β2-ICI118-551
15.15Single4EJ4Naltrindole4EJ4-δ-Naltrindole
15.15Single4GBRS-Carazolol4GBR-β2-S-Carazolol
15.15Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
15.15Single4QKX35V4QKX-β2-35V
15.15Single4YAYZD-71554YAY-AT1-ZD-7155
15.15Single5TGZAM65385TGZ-CB1-AM6538
15.15Single5UENDU1725UEN-A1-DU172
15.15Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
15.15Single6FFHFenobam6FFH-mGlu5-Fenobam
15.15Single6H7MSalbutamol6H7M-β1-Salbutamol
15.15Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
15.15Single6PS1Timolol6PS1-β2-Timolol
15.15Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
15.15Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
15.15Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
15.15Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
15.15Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
15.15Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
15.15Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
15.15Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
15.15Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
15.15Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
15.15Single7V3ZCP559407V3Z-CB1-CP55940
15.15Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
15.15Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
15.15Single8CU6LJ-45178CU6-A2A-LJ-4517
15.15Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
15.15Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
15.15Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
15.15Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
15.15Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
15.15Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
15.15Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.15Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.15Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.15Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.15Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.15Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.15Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.15Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.15Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.15Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.15Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
15.15Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
15.15Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
15.15Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
15.15Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
15.15Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
15.15Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
15.15Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
15.15Single8JXRLSD8JXR-D1-LSD
15.15Single8K5DGSK2560738K5D-HCA2-GSK256073
15.15Single8PJKST1718PJK-5-HT1A-ST171-Gi1/β1/γ1
15.15Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
15.15Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
15.15Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.15Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.15Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
15.15Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
15.15Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
15.15Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
15.15Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
15.15Single9CHXS-Carazolol9CHX-β2-S-Carazolol
15.15Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
15.15Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
15.15Single9IZCMK19039IZC-HCA2-MK1903-Gi1/β1/γ2
15.15Single9JEAAtropine9JEA-M1-Atropine
15.15Single9PQD(6m)-1-methyl-6-(1,2,5,6-tetrahydropyridin-3-yl)-1h-indole9PQD-α2a-(6m)-1-methyl-6-(1,2,5,6-tetrahydropyridin-3-yl)-1h-indole
15.15Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
15.15Consensus5ht5_onOrthosteric Ligand5ht5a_on
15.15Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
15.15Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
15.15Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
15.15Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
15.15Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
15.15Consensusdopamine_offOrthosteric Ligandd2_off d3_off
15.15Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
15.15Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
15.15Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
15.15Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
15.15Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
15.15Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
15.15Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
15.15Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
15.15Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
15.00Single3OE0CVX153OE0-CXCR4-CVX15
15.00Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
15.00Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
15.00Single8W8YGamma-MSH8W8Y-MC3-γ-MSH-Ca-Gs/β1/γ2
15.00Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
15.00Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
15.00Single9M1OMorphine-Modulating Neuropeptide B9M1O-NPFF2-Morphine-Modulating Neuropeptide B-Gi1/β1/γ2
15.00Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
15.00Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
14.71Single2RH1S-Carazolol2RH1-β2-S-Carazolol
14.71Single2Y03Isoprenaline2Y03-β1-Isoprenaline
14.71Single2YCWS-Carazolol2YCW-β1-S-Carazolol
14.71Single4JKVTaladegib4JKV-SMO-Taladegib
14.71Single5D6LS-Carazolol5D6L-β2-S-Carazolol
14.71Single5JQHS-Carazolol5JQH-β2-S-Carazolol
14.71Single5WIUNemonapride5WIU-D4-Nemonapride
14.71Single5WIVNemonapride5WIV-D4-Nemonapride-Na
14.71Single5WQCEMPA5WQC-OX2-EMPA
14.71Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
14.71Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
14.71Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
14.71Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
14.71Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
14.71Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
14.71Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
14.71Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
14.71Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
14.71Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
14.71Single7C61Ergotamine7C61-5-HT1B-Ergotamine
14.71Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
14.71Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
14.71Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
14.71Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
14.71Single7SINNPS-21437SIN-CaS-NPS-2143
14.71Single7SINNPS-21437SIN-CaS-NPS-2143
14.71Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
14.71Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
14.71Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
14.71Single7WC6LSD7WC6-5-HT2A-LSD
14.71Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
14.71Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.71Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
14.71Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.71Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
14.71Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
14.71Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
14.71Single8JXSPF-61428JXS-D1-PF-6142
14.71Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
14.71Single8QOTNanobody-E8QOT-μ-Nanobody-E
14.71Single8S4DCMF-0198S4D-Apelin-CMF-019
14.71Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
14.71Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
14.71Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
14.71Single8ZMFA1L108ZMF-5-HT2C-A1L10
14.71Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
14.71Single8ZVZBW245C8ZVZ-DP1-BW245C-Gs/β1/γ2
14.71Single8ZYTNeurotensin peptide 8-138ZYT-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
14.71Single9ARYSerotonin9ARY-5-HT2A-Serotonin-chim(NtGi1-Gs-CtGq)/β1/γ2
14.71Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
14.71Single9B9ZA1AKO9B9Z-CB1-A1AKO
14.71Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
14.71Single9GE2ML1849GE2-GPR55-ML184-chim(NtGi1-G13)/β1/γ2
14.71Single9HC04YI9HC0-mGlu5-4YI
14.71Single9I52A1IZU9I52-D1-A1IZU-Gs/β1/γ2
14.71Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
14.71Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
14.71Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
14.71Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
14.71Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
14.71Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
14.71Consensusadgrg2_onOrthosteric Ligand7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
14.71Consensusadgrg2_on_gpOrthosteric Ligand7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
14.71Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
14.71Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
14.71Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
14.71Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
14.71Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
14.71Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
14.71Consensusamine_offonOrthosteric Ligandamine_off amine_on
14.71Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
14.71Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
14.71Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
14.71Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
14.71Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
14.71Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
14.71Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
14.71Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
14.71Consensusep_offOrthosteric Ligandep4_off
14.71Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
14.71Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
14.71Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
14.71Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
14.71Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
14.71Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.71Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.71Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
14.71Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
14.63Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
14.63Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
14.63Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
14.63Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
14.29Single3P0GBI1671073P0G-β2-BI167107
14.29Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
14.29Single4DJHJDTic4DJH-κ-JDTic
14.29Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
14.29Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
14.29Single5D5AS-Carazolol5D5A-β2-S-Carazolol
14.29Single5D5BS-Carazolol5D5B-β2-S-Carazolol
14.29Single5V56TC1145V56-SMO-TC114
14.29Single5V57TC1145V57-SMO-TC114
14.29Single5XR8AM8415XR8-CB1-AM841
14.29Single5XRAAM115425XRA-CB1-AM11542
14.29Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
14.29Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
14.29Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
14.29Single6H7JIsoprenaline6H7J-β1-Isoprenaline
14.29Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
14.29Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
14.29Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
14.29Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
14.29Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
14.29Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
14.29Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single7FEECP559407FEE-CB1-CP55940-ZCZ011
14.29Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
14.29Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
14.29Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
14.29Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29Single7XKDBeta-Hydroxyandrosterone7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
14.29Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
14.29Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
14.29Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
14.29Single8EA0Iperoxo8EA0-M3-Iperoxo
14.29Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
14.29Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
14.29Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
14.29Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
14.29Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
14.29Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
14.29Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
14.29Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
14.29Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
14.29Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
14.29Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
14.29Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
14.29Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
14.29Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
14.29Single8X9S5alpha-DHT8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
14.29Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
14.29Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
14.29Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
14.29Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
14.29Single9AS9RS130-1809AS9-5-HT2A-RS130-180
14.29Single9ASARS130-1809ASA-5-HT2A-RS130-180-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
14.29Single9EGOYVF9EGO-CB1-YVF-Gi1/β1/γ2
14.29Single9I54A1IZV9I54-D1-A1IZV-Gs/β1/γ2
14.29Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
14.29Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
14.29Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
14.29Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
14.29Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
14.29Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
14.29Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
14.29Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
14.29Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
14.29Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
14.29Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
14.29Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
14.29Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
13.95Single7SK3CXCL127SK3-ACKR3-CXCL12
13.95Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
13.89Single4AMIBucindolol4AMI-β1-Bucindolol
13.89Single4LDEBI1671074LDE-β2-BI167107
13.89Single4XEENeurotensin4XEE-NTS1-Neurotensin
13.89Single4XESNeurotensin4XES-NTS1-Neurotensin
13.89Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
13.89Single5TZYMK8666; AP85TZY-FFA1-MK8666; AP8
13.89Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
13.89Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
13.89Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
13.89Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
13.89Single6KQICP559406KQI-CB1-CP55940-Org27569
13.89Single6MXTSalmeterol6MXT-β2-Salmeterol
13.89Single6YVRNTS8-136YVR-NTS1-NTS8-13
13.89Single6ZG4HTL00099366ZG4-M1-HTL0009936
13.89Single7DFPSpiperone7DFP-D2-Spiperone
13.89Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
13.89Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
13.89Single7K15MKD0467K15-BLT1-MKD046-Na
13.89Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
13.89Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
13.89Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
13.89Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
13.89Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
13.89Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.89Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
13.89Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
13.89Single8JD3JNJ-404118138JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
13.89Single8JJLOlodaterol8JJL-β2-Olodaterol
13.89Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
13.89Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
13.89Single8JWY2-1188JWY-A2A-2-118
13.89Single8JWZAB9288JWZ-A2A-AB928-Na
13.89Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.89Single8XJNCloprosetnol8XJN-TXA2-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
13.89Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
13.89Single8XWACXCL18XWA-CXCR2-CXCL1
13.89Single8XWSCXCL58XWS-CXCR2-CXCL5
13.89Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
13.89Single9AU0BW245C9AU0-DP1-BW245C-Gs/β1/γ2
13.89Single9GGGI-BOP9GGG-TXA2-I-BOP-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.89Single9GL2Befiradol9GL2-5-HT1A-Befiradol-Gs/β1/γ2
13.89Single9M4QDoxazosin9M4Q-Alpha1A-Doxazosin
13.89Consensusalpha1_offOrthosteric Ligandalpha1a_off
13.89Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
13.89Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
13.89Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
13.89Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
13.89Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
13.89Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
13.89Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
13.89Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
13.89Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
13.89Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
13.89Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
13.89Consensuslpa_offOrthosteric Ligandlpa1_off
13.89Consensuslpl_offOrthosteric Ligands1p_off lpa_off
13.89Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
13.89Consensusorexin_onOrthosteric Ligandox2_on
13.89Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
13.79Single3RFMCaffeine3RFM-A2A-Caffeine
13.79Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
13.79Single8A2OTheophylline8A2O-A2A-Theophylline-Na
13.79Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
13.64Single9KDFRES-701-39KDF-ETB-RES-701-3
13.64Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
13.51Single4BUONeurotensin4BUO-NTS1-Neurotensin
13.51Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
13.51Single5CGDHTL142425CGD-mGlu5-HTL14242
13.51Single5X93K-87945X93-ETB-K-8794
13.51Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
13.51Single6H7LDobutamine6H7L-β1-Dobutamine
13.51Single6IBLArformoterol6IBL-β1-Arformoterol
13.51Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
13.51Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
13.51Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
13.51Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.51Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
13.51Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
13.51Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-SBI-553-chim(NtGi1-Go)/β1/γ2
13.51Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
13.51Single8JPFNeurotensin8JPF-NTS1-Neurotensin-SBI-553
13.51Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
13.51Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
13.51Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
13.51Single8XJOU466198XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
13.51Single8XVJMacitentan8XVJ-ETA-Macitentan
13.51Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
13.51Single8ZPLHF511168ZPL-CXCR4-HF51116
13.51Single9AS02-bromo-LSD9AS0-5-HT2A-2-bromo-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
13.51Single9CGJC6-Quino9CGJ-δ-C6-Quino-Gi1/β1/γ2
13.51Single9M1HProstaglandin E29M1H-EP1-Prostaglandin E2-chim(NtGi1-Gs-CtGq)/β1/γ2
13.51Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
13.51Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
13.51Consensusendothelin_offOrthosteric Ligandetb_off
13.51Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
13.51Consensusfp-alpha_onOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
13.51Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
13.51Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.51Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.51Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
13.51Consensusprostanoid_offOrthosteric Ligandep_off dp_off
13.51Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
13.51Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
13.51Consensustp_onOrthosteric Ligand8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
13.51Consensustp_on_gpOrthosteric Ligand8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
13.33Single3UZAGTPL92363UZA-A2A-GTPL9236
13.33Single4XNWMRS25004XNW-P2Y1-MRS2500
13.33Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
13.33Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
13.33Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
13.33Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
13.33Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
13.33Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.33Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
13.33Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
13.33Single8IW72-Phenylethylamine8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
13.33Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
13.33Single8IY6Endothelin-18IY6-ETB-Endothelin-1
13.33Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
13.33Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
13.33Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
13.33Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
13.33Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
13.33Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
13.33Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
13.33Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
13.33Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
13.33Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
13.33Single9LRCHistamine9LRC-H4-Histamine
13.33Single9LREHistamine9LRE-H4-Histamine-Gi1/β1/γ2
13.33Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
13.33Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
13.33Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
13.33Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
13.33Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
13.33Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
13.16Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
13.16Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
13.16Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
13.16Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
13.16Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
13.16Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
13.16Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
13.16Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
13.16Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
13.16Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
13.16Single9JH6C20:0 Ceramide9JH6-CysLT2-C20:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
13.04Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
12.90Single3OE9IT1t3OE9-CXCR4-IT1t
12.90Single5L7IVismodegib5L7I-SMO-Vismodegib
12.90Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
12.90Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
12.90Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
12.90Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
12.90Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
12.90Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
12.90Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
12.90Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
12.90Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
12.90Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
12.90Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
12.90Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
12.90Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab
12.90Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
12.90Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
12.90Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
12.90Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
12.90Single8YN7Immethridine8YN7-H3-Immethridine-Go/β1/γ2
12.90Single9EPRRetinal9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
12.90Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
12.90Single9LMPNE52-QQ579LMP-GPR4-NE52-QQ57
12.90Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
12.82Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
12.82Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
12.82Single8IEIA1LYA8IEI-GPR156-A1LYA
12.82Single8IEPA1LYA8IEP-GPR156-A1LYA
12.82Single8IEPA1LYA8IEP-GPR156-A1LYA
12.82Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
12.82Single8KIGSHU91198KIG-MC3-SHU9119-Ca
12.82Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
12.82Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
12.82Single9J0IUDP-Glucuronic acid9J0I-P2Y14-UDP-Glucuronic acid-Gi1/β1/γ2
12.82Single9M4TSilodosin9M4T-Alpha1A-Silodosin
12.82Consensussomatostatin_offOrthosteric Ligandsst2_off
12.77Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
12.50Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
12.50Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
12.50Single4BWBNeurotensin4BWB-NTS1-Neurotensin
12.50Single4S0VSuvorexant4S0V-OX2-Suvorexant
12.50Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
12.50Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
12.50Single5WS3EMPA5WS3-OX2-EMPA
12.50Single6B73MP11046B73-κ-MP1104
12.50Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
12.50Single6ME2Ramelteon6ME2-MT1-Ramelteon
12.50Single6ME9Ramelteon6ME9-MT2-Ramelteon
12.50Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
12.50Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
12.50Single6TODEMPA6TOD-OX1-EMPA-Na
12.50Single6TPJSuvorexant6TPJ-OX2-Suvorexant
12.50Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
12.50Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
12.50Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
12.50Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
12.50Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
12.50Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
12.50Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
12.50Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
12.50Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
12.50Single7VVOPTH7VVO-PTH1-PTH-Gs/β1/γ2
12.50Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
12.50Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
12.50Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Single8GNGIstradefylline8GNG-A2A-Istradefylline
12.50Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
12.50Single8IEBA1LYA8IEB-GPR156-A1LYA
12.50Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
12.50Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
12.50Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
12.50Single8U4PAMD31008U4P-CXCR4-AMD3100-Gi1/β1/γ2
12.50Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
12.50Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
12.50Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
12.50Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
12.50Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
12.50Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ2
12.50Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
12.50Single8YYWAlpha-ketoglutarate8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
12.50Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
12.50Single9H2XA1IR19H2X-A2A-A1IR1-Na
12.50Single9IQRMuscarinic toxin 39IQR-α2a-Muscarinic toxin 3
12.50Single9J0FNADH9J0F-P2Y14-NADH-Gi1/β1/γ2
12.50Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
12.50Single9KPESA09KPE-TAS2R16-SA0-Gi1/β1/γ2
12.50Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
12.50Consensusalpha2_offOrthosteric Ligandalpha2c_off
12.50Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
12.50Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
12.50Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
12.50Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
12.50Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
12.50Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
12.50Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
12.50Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
12.50Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
12.50Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
12.50Consensusorexin_offOrthosteric Ligandox2_off ox1_off
12.50Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
12.50Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
12.50Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
12.50Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
12.50Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
12.20Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
12.20Single6W25SHU91196W25-MC4-SHU9119-Ca
12.20Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
12.20Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
12.20Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
12.20Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
12.12Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
12.12Single3REYXAC3REY-A2A-XAC
12.12Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
12.12Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
12.12Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
12.12Single6KUXRS-799486KUX-α2a-RS-79948
12.12Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
12.12Single6PS5S-Propranolol6PS5-β2-S-Propranolol
12.12Single6TP3Nemorexant6TP3-OX1-Nemorexant
12.12Single6V9SGTPL114036V9S-OX1-GTPL11403
12.12Single6VI4JDTic6VI4-κ-JDTic
12.12Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
12.12Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
12.12Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
12.12Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
12.12Single6ZG9GSK10347026ZG9-M1-GSK1034702
12.12Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
12.12Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
12.12Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
12.12Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
12.12Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
12.12Single7F61PF-036547467F61-H3-PF-03654746
12.12Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
12.12Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.12Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
12.12Single7T94Acetylcholine7T94-M2-Acetylcholine-LY2119620-chim(NtGi1-Go)/β1/γ2
12.12Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
12.12Single7UTZDPPC7UTZ-TSH-TR1402-DPPC-Gs/β1/γ2
12.12Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
12.12Single7VV6C48/807VV6-MRGPRX2-C48/80
12.12Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
12.12Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
12.12Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.12Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
12.12Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
12.12Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
12.12Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
12.12Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
12.12Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
12.12Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
12.12Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
12.12Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
12.12Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
12.12Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
12.12Single8K9LDamgo8K9L-μ-Damgo-BMS-986122-Gi3/β1/γ1
12.12Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
12.12Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.12Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.12Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
12.12Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
12.12Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
12.12Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
12.12Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
12.12Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
12.12Single8Y6YGLPG09748Y6Y-FFA2-GLPG0974
12.12Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
12.12Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
12.12Single9AS5Mescaline9AS5-5-HT2A-Mescaline
12.12Single9AS6Mescaline9AS6-5-HT2A-Mescaline-chim(NtGi1-Gs-CtGq)/β1/γ2
12.12Single9JFUNE52-QQ579JFU-GPR4-NE52-QQ57
12.12Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
12.12Consensusalpha1_onOrthosteric Ligandalpha1a_on
12.12Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
12.12Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
12.12Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
12.12Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
12.12Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
12.12Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
12.12Consensusgrh_offOrthosteric Ligandgnrh1_off
12.12Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
11.90Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
11.90Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
11.90Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
11.90Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
11.90Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
11.90Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
11.90Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
11.76Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
11.76Single2Y01Dobutamine2Y01-β1-Dobutamine
11.76Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
11.76Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
11.76Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
11.76Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
11.76Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
11.76Single4MQSIperoxo4MQS-M2-Iperoxo
11.76Single4QIMANTA XV4QIM-SMO-ANTA XV
11.76Single4U14Tiotropium4U14-M3-Tiotropium
11.76Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
11.76Single5DHHSB-6121115DHH-NOP-SB-612111
11.76Single5DSGTiotropium5DSG-M4-Tiotropium
11.76Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
11.76Single5UIGCmpd-15UIG-A2A-Cmpd-1
11.76Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
11.76Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
11.76Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
11.76Single6D27CAY104716D27-DP2-CAY10471
11.76Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
11.76Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
11.76Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/β1/γ2
11.76Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
11.76Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
11.76Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
11.76Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
11.76Single7BU7BI1671077BU7-β1-BI167107
11.76Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
11.76Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
11.76Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
11.76Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
11.76Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
11.76Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
11.76Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
11.76Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
11.76Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
11.76Single7WC7Lisuride7WC7-5-HT2A-Lisuride
11.76Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
11.76Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
11.76Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
11.76Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
11.76Single7YXAONO-54306087YXA-S1P5-ONO-5430608
11.76Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
11.76Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
11.76Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
11.76Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
11.76Single8JJOAlprenolol8JJO-β2-Alprenolol
11.76Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
11.76Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
11.76Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
11.76Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
11.76Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
11.76Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
11.76Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
11.76Single8X64Desloratadine8X64-H1-Desloratadine
11.76Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
11.76Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
11.76Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
11.76Single8YN8Proxyfan8YN8-H3-Proxyfan-Go/β1/γ2
11.76Single9AS1DMT9AS1-5-HT2A-DMT
11.76Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
11.76Single9IYAONO-97105319IYA-GPR55-ONO-9710531
11.76Single9PLNN-(5-methylnaphthalen-1-yl)pyridin-4-amine9PLN-α2a-N-(5-methylnaphthalen-1-yl)pyridin-4-amine
11.76Single9PLON-(5-methylnaphthalen-1-yl)pyridin-4-amine9PLO-α2a-N-(5-methylnaphthalen-1-yl)pyridin-4-amine-Go/β1/γ2
11.76Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
11.76Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
11.76Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
11.76Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
11.76Consensusalpha2_onOrthosteric Ligandalpha2b_on
11.76Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
11.76Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
11.76Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
11.76Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
11.76Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
11.76Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
11.76Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
11.76Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
11.76Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
11.76Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
11.63Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.43Single2Y00Dobutamine2Y00-β1-Dobutamine
11.43Single4NTJAZD12834NTJ-P2Y12-AZD1283
11.43Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
11.43Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
11.43Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
11.43Single5CGCHTL142425CGC-mGlu5-HTL14242
11.43Single5T1ABMS-6815T1A-CCR2-BMS-681-PubChem 12093170
11.43Single5TVNLSD5TVN-5-HT2B-LSD
11.43Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
11.43Single6D26Fevipiprant6D26-DP2-Fevipiprant
11.43Single6E67BI1671076E67-β2-BI167107-Gs(CT)
11.43Single6LUQHaloperidol6LUQ-D2-Haloperidol
11.43Single6PS6Timolol6PS6-β2-Timolol
11.43Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
11.43Single7C4SS1P7C4S-S1P3-S1P
11.43Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
11.43Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
11.43Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
11.43Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
11.43Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
11.43Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
11.43Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
11.43Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
11.43Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
11.43Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
11.43Single9ARZ2-bromo-LSD9ARZ-5-HT2A-2-bromo-LSD
11.43Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
11.43Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
11.43Single9EHSLUF76029EHS-A3A-LUF7602
11.43Single9F33FOB02-04A9F33-D3-FOB02-04A-Go/β1/γ2
11.43Single9F34FOB02-04A9F34-D3-FOB02-04A-Go/β1/γ2
11.43Single9HAPTolvaptan9HAP-V2-Tolvaptan
11.43Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
11.43Single9K07DSO-5a9K07-BB3-DSO-5a-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.43Single9KPFSA09KPF-TAS2R16-SA0-Gi1/β1/γ2
11.43Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
11.43Consensusblt_offOrthosteric Ligandblt1_off
11.43Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
11.43Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
11.43Consensusdp_offOrthosteric Liganddp2_off
11.43Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
11.43Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
11.11Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
11.11Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
11.11Single4BV0Neurotensin4BV0-NTS1-Neurotensin
11.11Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
11.11Single5TZRMK86665TZR-FFA1-MK8666
11.11Single6OS1TRV0266OS1-AT1-TRV026
11.11Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
11.11Single6TQ7SB-3348676TQ7-OX1-SB-334867
11.11Single6WGTLSD6WGT-5-HT2A-LSD
11.11Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
11.11Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
11.11Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
11.11Single7F1TMIP-1a7F1T-CCR5-MIP-1a
11.11Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
11.11Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
11.11Single7R0CAVP7R0C-V2-AVP-Arrestin2
11.11Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
11.11Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
11.11Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
11.11Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.11Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
11.11Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
11.11Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single8JD5JNJ-40411813; ADX881788JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
11.11Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
11.11Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
11.11Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
11.11Single8YNTSNAP-948478YNT-MCH1-SNAP-94847
11.11Single8ZW0PGD28ZW0-DP1-PGD2-Gs/β1/γ2
11.11Single8ZWFJR14a8ZWF-C3aB-JR14a
11.11Single9UY3Anamorelin9UY3-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
11.11Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
11.11Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
11.11Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
11.11Consensusneurotensin_onOrthosteric Ligandnts1_on
11.11Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
11.11Consensustachykinin_offOrthosteric Ligandnk1_off
10.87Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
10.81Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
10.81Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
10.81Single4PY02MeSATP4PY0-P2Y12-2MeSATP
10.81Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
10.81Single5X33BIIL2605X33-BLT1-BIIL260
10.81Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
10.81Single6CM4Risperidone6CM4-D2-Risperidone
10.81Single6IIURamatroban6IIU-TXA2-Ramatroban
10.81Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
10.81Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
10.81Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
10.81Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
10.81Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
10.81Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
10.81Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.81Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
10.81Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
10.81Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.81Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
10.81Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
10.81Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
10.81Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
10.81Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
10.81Single8Y6WTUG-13758Y6W-FFA2-TUG-1375-4-CMTB-Gi1/β1/γ2
10.81Single9BJKNAM9BJK-μ-Naloxone-NAM
10.81Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
10.81Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
10.81Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
10.81Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
10.81Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
10.71Single8GEJConstrained Epinephrine8GEJ-β2-Constrained Epinephrine-Gs/β1/γ2
10.53Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
10.53Single6K1QIRL25006K1Q-ETB-IRL2500
10.53Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
10.53Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
10.53Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
10.53Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
10.53Single9GG5U466199GG5-TXA2-U46619-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.53Single9JH5C16:0 Ceramide9JH5-CysLT2-C16:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
10.53Consensuschemerin_onOrthosteric Ligandcml1_on
10.53Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
10.53Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
10.53Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
10.34Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
10.34Single7V68LY21196207V68-M4-Iperoxo-LY2119620-Gi1/β1/γ2
10.34Single8PWNTheophylline8PWN-A2A-Theophylline
10.34Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
10.26Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
10.26Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.26Single8XQJJN2418XQJ-Apelin-JN241
10.26Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
10.26Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
10.26Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
10.26Consensuskisspeptin_onOrthosteric Ligandkiss1_on
10.00Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
10.00Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
10.00Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
10.00Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.00Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.00Single8IEBA1LYA8IEB-GPR156-A1LYA
10.00Single8IEIA1LYA8IEI-GPR156-A1LYA
10.00Single8IWM2-Phenylethylamine8IWM-TA9-2-Phenylethylamine
10.00Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
10.00Single8WC5Tetramethylammonium Ion8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
10.00Single8WKYPG-9348WKY-MC4-PG-934
10.00Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
10.00Single8Y02Retinal8Y02-OPN1SW-Retinal-Gi1/β1/γ2
10.00Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
10.00Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
10.00Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
10.00Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
10.00Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
10.00Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
10.00Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
10.00Consensusp2y_offOrthosteric Ligandp2y1_off
10.00Consensussensory_onOrthosteric Ligandopsins_on
9.76Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
9.76Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
9.76Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
9.76Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
9.76Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
9.68Single3OE6IT1t3OE6-CXCR4-IT1t
9.68Single3PQRAll-trans-Retinal3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
9.68Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
9.68Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
9.68Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
9.68Single6ME5Agomelatine6ME5-MT1-Agomelatine
9.68Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
9.68Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
9.68Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
9.68Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
9.68Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.68Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
9.68Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
9.68Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
9.68Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
9.68Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
9.68Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
9.68Single9JHJC18:0 Ceramide9JHJ-FPR2-ALX-C18:0 Ceramide-Gi1/β1/γ2
9.68Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
9.68Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
9.68Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
9.68Consensusgi_sensoryOrthosteric Ligandgi_opsins
9.68Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
9.68Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
9.38Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
9.38Single3PBLEticlopride3PBL-D3-Eticlopride
9.38Single4O9RCyclopamine4O9R-SMO-Cyclopamine
9.38Single6HLLCP999946HLL-NK1-CP99994
9.38Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
9.38Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
9.38Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
9.38Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
9.38Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
9.38Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
9.38Single7SRQLSD7SRQ-5-HT2B-LSD
9.38Single7UL2SR486927UL2-NTS1-SR48692-Na
9.38Single7V68Iperoxo7V68-M4-Iperoxo-LY2119620-Gi1/β1/γ2
9.38Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
9.38Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
9.38Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
9.38Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
9.38Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
9.38Single8HSCFab0468HSC-GPR20-Fab046-Gi1/β1/γ2
9.38Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
9.38Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
9.38Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
9.38Single8YKDDehydroepiandrosterone8YKD-ADGRG2-Dehydroepiandrosterone-chim(NtGi1-Gs)/β1/γ2
9.38Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
9.38Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
9.38Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
9.38Single8ZYUNeurotensin peptide 8-138ZYU-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
9.38Single9B9Y7DY9B9Y-CB1-7DY
9.38Single9E7RGB889E7R-PAR2-GB88-chim(NtGi1L-Gs-CtGq)/β1/γ2
9.38Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
9.38Single9IXJHistamine9IXJ-H2-Histamine-Gs/β1/γ2
9.38Single9IZDCHBA9IZD-HCA1-CHBA-Gi1/β1/γ2
9.38Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
9.38Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
9.38Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
9.38Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
9.38Consensusneurotensin_offOrthosteric Ligandnts1_off
9.38Consensusnts1_offOrthosteric Ligand7UL2-NTS1-SR48692-Na
9.30Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
9.09Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
9.09Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
9.09Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
9.09Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
9.09Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
9.09Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
9.09Single3ODUIT1t3ODU-CXCR4-IT1t
9.09Single4QINSAG1.54QIN-SMO-SAG1.5
9.09Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
9.09Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
9.09Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
9.09Single7BR3Elagolix7BR3-GnRH1-Elagolix
9.09Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
9.09Single7F8ULintitript7F8U-CCKA-Lintitript
9.09Single7F8YDevazepide7F8Y-CCKA-Devazepide
9.09Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
9.09Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
9.09Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
9.09Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
9.09Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
9.09Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
9.09Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
9.09Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
9.09Single7XRRLemborexant7XRR-OX2-Lemborexant
9.09Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
9.09Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
9.09Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.09Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
9.09Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
9.09Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.09Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
9.09Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
9.09Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
9.09Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
9.09Single8YYWAlpha-ketoglutarate8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
9.09Single9K6LSA09K6L-TAS2R16-SA0-Gi2/β1/γ2
9.09Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
9.09Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
9.09Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
9.09Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
9.09Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
8.82Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
8.82Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
8.82Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
8.82Single6A94Zotepine6A94-5-HT2A-Zotepine
8.82Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
8.82Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
8.82Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
8.82Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
8.82Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
8.82Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
8.82Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
8.82Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
8.82Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
8.82Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
8.82Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
8.82Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
8.82Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
8.82Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
8.82Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
8.82Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
8.82Single8YRGFospropofol8YRG-MRGPRX4-Fospropofol-chim(NtGi1-Gs-CtGq)/β1/γ2
8.82Single9ARXSerotonin9ARX-5-HT2A-Serotonin
8.82Single9AS3LSD9AS3-5-HT2A-LSD
8.82Single9AS4LSD9AS4-5-HT2A-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
8.82Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
8.82Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
8.82Single9BA0A1AKN9BA0-CB1-A1AKN
8.82Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
8.82Single9JMDAzithromycin9JMD-Motilin-Azithromycin-chim(Gs-CtGq)/β1/γ2
8.82Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Gi1/β1/γ2
8.82Single9KPDSA09KPD-TAS2R16-SA0-chim(Gs-CtGt3)/β1/γ2
8.82Single9LRDHistamine9LRD-H1-Histamine-Gi1/β1/γ2
8.82Single9M2FNeuropeptide FF9M2F-NPFF1-Neuropeptide FF-Gi1/β1/γ2
8.82Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
8.82Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
8.82Consensusopsins_offOrthosteric Ligandrhodopsin_off
8.82Consensussensory_offOrthosteric Ligandopsins_off
8.57Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
8.57Single2Y02Carmoterol2Y02-β1-Carmoterol
8.57Single4DAJTiotropium4DAJ-M3-Tiotropium
8.57Single5DHGC-355DHG-NOP-C-35
8.57Single5T04Neurotensin5T04-NTS1-Neurotensin
8.57Single6DRXLisuride6DRX-5-HT2B-Lisuride
8.57Single6GPSMK08126GPS-CCR2-MK0812
8.57Single6IIVDaltroban6IIV-TXA2-Daltroban
8.57Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
8.57Single7F83PF-051904577F83-Ghrelin-PF-05190457
8.57Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
8.57Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
8.57Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
8.57Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
8.57Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
8.57Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
8.57Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
8.57Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
8.57Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
8.57Single8TH3AT118-H Nanobody8TH3-AT1-AT118-H Nanobody
8.57Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
8.57Single8X63Mepyramine8X63-H1-Mepyramine
8.57Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
8.57Single8ZYYNeurotensin peptide 8-138ZYY-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
8.57Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
8.57Single9IMATalquetamab9IMA-GPRC5D-Talquetamab
8.57Single9JGKBalovaptan9JGK-5-HT2B-Balovaptan
8.57Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
8.57Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
8.57Consensuscck_offOrthosteric Ligandccka_off
8.57Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
8.57Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
8.57Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
8.57Consensushistamine_offOrthosteric Ligandh1_off
8.33Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
8.33Single6GPXMK08126GPX-CCR2-MK0812
8.33Single6HLPNetupitant6HLP-NK1-Netupitant
8.33Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
8.33Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
8.33Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
8.33Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
8.33Single7W41PD1762527W41-BB2-PD176252
8.33Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
8.33Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
8.33Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
8.33Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
8.33Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
8.33Consensusbombesin_offOrthosteric Ligandbb2_off
8.11Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
8.11Single6J20Aprepitant6J20-NK1-Aprepitant
8.11Single7B6WCyclazosin7B6W-α1b-Cyclazosin
8.11Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
8.11Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
8.11Single8GDBPGE28GDB-EP4-PGE2-Gs/β1/γ2
8.11Single8JD5JNJ-40411813; ADX881788JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
8.11Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
8.11Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Gi1/β1/γ1
8.11Single8XVLZibotentan8XVL-ETA-Zibotentan
8.11Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
7.89Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
7.89Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
7.89Single8XQJJN2418XQJ-Apelin-JN241
7.89Single9CM3TUG-13759CM3-FFA2-TUG-1375-Compound 187-chim(NtGi1L-Gs-CtGq)/β1/γ2
7.89Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
7.89Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
7.69Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
7.69Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
7.69Single8T3OTUG-8918T3O-FFA4-TUG-891-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.50Single6KNMJN241-96KNM-Apelin-JN241-9
7.50Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
7.50Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
7.50Single9CM7TUG-13759CM7-FFA2-TUG-1375-AZ-1729-Gi1/β1/γ2
7.50Single9JF4PD1683689JF4-BB1-PD168368
7.50Single9NS9TUG-13759NS9-FFA2-TUG-1375-Compound 187-Gi1/β1/γ2
7.41Consensusclass-b2_onOrthosteric Ligandadgrg_on adgrf_on adgrl_on adgre_on adgrd_on
7.41Consensusclass-b2_on_gpOrthosteric Ligandadgrg_on_gp adgrf_on_gp adgrl_on_gp adgre_on_gp adgrd_on_gp
7.32Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
7.14Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
6.90Single4A4MAll-trans-Retinal4A4M-Rhodopsin-All-trans-Retinal-Gt(CT)
6.90Single5EN0All-trans-Retinal5EN0-Rhodopsin-All-trans-Retinal-Gt(CT)
6.90Single5MZPCaffeine5MZP-A2A-Caffeine-Na
6.67Single3PXOAll-trans-Retinal3PXO-Rhodopsin-All-trans-Retinal
6.67Single5DYSAll-trans-Retinal5DYS-Rhodopsin-All-trans-Retinal
6.67Single6VCBLSN31604406VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
6.67Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
6.67Single8HS2Fab0468HS2-GPR20-Fab046
6.67Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
6.45Single2HPYAll-trans-Retinal2HPY-Rhodopsin-All-trans-Retinal
6.45Single3OE8IT1t3OE8-CXCR4-IT1t
6.45Single6OY9All-trans-Retinal6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
6.45Single6TQ9SB-4081246TQ9-OX1-SB-408124
6.45Single6XBM5LWE6XBM-SMO-5LWE-Gi1/β1/γ2
6.45Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Gi1/β1/γ2
6.45Single9CHUNoradrenaline9CHU-β2-Noradrenaline
6.45Single9IVMLSN33188399IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
6.45Consensusgs_histamineOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
6.45Consensush2_onOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
6.25Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
6.25Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
6.25Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
6.25Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/β1/γ2
6.25Single8JPSCCL78JPS-ACKR1-CCL7
6.25Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
6.25Consensus5ht2_onOrthosteric Ligand5ht2b_on
6.25Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.25Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
6.06Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
6.06Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
6.06Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
6.06Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
6.06Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
6.06Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.06Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
6.06Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
6.06Single7XP6Strychnine7XP6-TAS2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
6.06Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
6.06Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
6.06Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.06Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
6.06Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
6.06Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.06Single8YN2Histamine8YN2-H1-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
6.06Single9AS2DMT9AS2-5-HT2A-DMT-chim(NtGi1-Gs-CtGq)/β1/γ2
6.06Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
6.06Consensusgq_nucleotideOrthosteric Ligandgq_p2y
6.06Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
5.88Single6C1QNDT95137276C1Q-C5a1-PMX53-NDT9513727
5.88Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
5.88Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.88Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
5.88Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
5.88Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.88Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
5.88Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
5.88Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
5.88Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
5.88Single8T3VDocosa-4,7,10,13,16,19-Hexaenoic acid8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.88Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
5.88Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
5.88Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
5.88Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
5.88Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
5.88Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.88Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
5.71Single3RZECidoxepin3RZE-H1-Cidoxepin
5.71Single6IQLL7458706IQL-D4-L745870
5.71Single6TPKRetosiban6TPK-OT-Retosiban
5.71Single6TPNHTL66416TPN-OX2-HTL6641
5.71Single8JD6VU03647708JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
5.71Single8RLNLUF58348RLN-A2A-LUF5834
5.71Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.71Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
5.71Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.71Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
5.71Single9IXXLTD49IXX-CysLT2-LTD4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.71Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
5.71Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
5.71Consensusvasop-oxy_offOrthosteric Ligandot_off
5.56Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
5.41Single5XPRBosentan5XPR-ETB-Bosentan
5.41Single6Z4SSR486926Z4S-NTS1-SR48692
5.41Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
5.41Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
5.41Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
5.26Single6E59L-7607356E59-NK1-L-760735
5.26Single9CLWTUG-13759CLW-FFA2-TUG-1375-4-CMTB-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.13Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
5.13Single8GTMBMK-C2038GTM-CRF1-BMK-C203
3.70Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
3.70Single6D35Cholesterol6D35-SMO-Cholesterol
3.70Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
3.70Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
3.70Single6UO8SKF975416UO8-GABAB1, GABAB2-SKF97541-GS39783
3.70Single6UO9SKF975416UO9-GABAB1, GABAB2-SKF97541
3.70Single6W2XPubChem 53110426W2X-GABAB1, GABAB2-PubChem 5311042
3.70Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042
3.70Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042
3.70Single7C7QBaclofen7C7Q-GABAB1, GABAB2-Baclofen-BHFF
3.70Single7C7SCGP546267C7S-GABAB1, GABAB2-CGP54626
3.70Single7CUMCGP546267CUM-GABAB1, GABAB2-CGP54626
3.70Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
3.70Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
3.70Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
3.70Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
3.70Single7DGEQuisqualate7DGE-mGlu1; mGlu1-Quisqualate
3.70Single7DTTCa7DTT-CaS-Ca-Ca
3.70Single7DTTCa7DTT-CaS-Ca-Ca
3.70Single7DTUTryptophan7DTU-CaS-Tryptophan
3.70Single7DTUTryptophan7DTU-CaS-Tryptophan
3.70Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
3.70Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
3.70Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
3.70Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
3.70Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
3.70Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
3.70Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
3.70Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
3.70Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
3.70Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
3.70Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
3.70Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
3.70Single7EB2Baclofen7EB2-GABAB2; GABAB1-Baclofen-rac-BHFF-Gi1/β1/γ2
3.70Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
3.70Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
3.70Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
3.70Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
3.70Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
3.70Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
3.70Single7FIHhCG7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
3.70Single7FIIhCG7FII-LH-hCG-chim(NtGi1-Gs)/β1/γ2
3.70Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
3.70Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
3.70Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
3.70Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
3.70Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
3.70Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
3.70Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
3.70Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
3.70Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
3.70Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
3.70Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
3.70Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
3.70Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
3.70Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
3.70Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
3.70Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
3.70Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
3.70Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
3.70Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
3.70Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
3.70Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
3.70Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
3.70Single7T9NM22 Fab7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
3.70Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
3.70Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
3.70Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
3.70Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
3.70Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
3.70Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
3.70Single7XW6M22 Fab7XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
3.70Single7XW7K1-707XW7-TSH-K1-70
3.70Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
3.70Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
3.70Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
3.70Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
3.70Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
3.70Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
3.70Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
3.70Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
3.70Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
3.70Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
3.70Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
3.70Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
3.70Single8JD0Glutamate8JD0-mGlu2; mGlu3-Glutamate-NAM563
3.70Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
3.70Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
3.70Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
3.70Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
3.70Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
3.70Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
3.70Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
3.70Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
3.70Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
3.70Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
3.70Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
3.70Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
3.70Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
3.70Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
3.70Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
3.70Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
3.70Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
3.70Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
3.70Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
3.70Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
3.70Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
3.70Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
3.70Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
3.70Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
3.70Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
3.70Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
3.70Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
3.70Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
3.70Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
3.70Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
3.70Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
3.70Single8WG9(2S)-2-amino-4-phosphonobutanoic acid8WG9-mGlu4; mGlu2-(2S)-2-amino-4-phosphonobutanoic acid
3.70Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
3.70Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
3.70Single8WGCLY3792688WGC-mGlu4; mGlu2-LY379268
3.70Single8WGDWAG; WA68WGD-mGlu4; mGlu2-WAG; WA6
3.70Single8WGDWAG; WA68WGD-mGlu4; mGlu2-WAG; WA6
3.70Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
3.70Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
3.70Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.70Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.70Single8WVXNorrin8WVX-LGR4-Norrin
3.70Single8WVYNorrin8WVY-LGR4-Norrin
3.70Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
3.70Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
3.70Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
3.70Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
3.70Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
3.70Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
3.70Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
3.70Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
3.70Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
3.70Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
3.70Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
3.70Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
3.70Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
3.70Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
3.70Single8XUMR-spondin-28XUM-LGR4-R-spondin-2
3.70Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
3.70Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
3.70Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
3.70Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
3.70Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
3.70Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
3.70Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
3.70Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
3.70Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
3.70Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
3.70Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
3.70Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
3.70Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
3.70Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
3.70Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
3.70Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
3.70Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
3.70Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
3.70Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
3.70Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
3.70Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
3.70Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
3.70Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
3.70Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
3.70Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
3.70Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
3.70Single9KHHNorrin9KHH-LGR4-Norrin
3.70Single9S37NB219S37-LGR4-NB21
3.70Single9UTBSucralose9UTB-TAS1R2; TAS1R3-Sucralose
3.57Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
3.57Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
3.57Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
3.57Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
3.57Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
3.57Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
3.57Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
3.57Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
3.57Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
3.57Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
3.57Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
3.57Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
3.57Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
3.57Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
3.57Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
3.57Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
3.45Single7KNUCalcitonin gene-related peptide-17KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
3.45Single7T9MCS-17 Antibody7T9M-TSH-CS-17 Antibody
3.45Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
3.45Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
3.33Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
3.33Single7FIGhCG7FIG-LH-hCG-chim(NtGi1L-Gs)/β1/γ2
3.33Single7UTZTR14027UTZ-TSH-TR1402-DPPC-Gs/β1/γ2
3.33Single7XW5TSH7XW5-TSH-TSH-ML109-Gs/β1/γ2
3.33Single7ZI0Cholesterol7ZI0-SMO-SAG-Cholesterol
3.33Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
3.33Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
3.23Single5L7DCholesterol5L7D-SMO-Cholesterol
3.23Single7T9ITSH7T9I-TSH-TSH-Gs/β1/γ2
3.23Single8I2GGlycoprotein hormones alpha chain8I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
3.12Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
3.12Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
3.12Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
3.12Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
3.03Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
3.03Single6OBAGTPL110746OBA-β2-S-Alprenolol-GTPL11074
3.03Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
3.03Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.03Single8J6QCompound 9n8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
3.03Single8XQPAristolochic acid A8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
2.94Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
2.94Single6TP4ACT-4622066TP4-OX1-ACT-462206
2.94Single7CKZMevidalen7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
2.94Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
2.94Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
2.94Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/β1/γ2
2.94Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
2.94Single8K9LBMS-9861228K9L-μ-Damgo-BMS-986122-Gi3/β1/γ1
2.94Single9AS7Psilocin9AS7-5-HT2A-Psilocin
2.86Single4K5YCP-3763954K5Y-CRF1-CP-376395
2.86Single4XNVBPTU4XNV-P2Y1-BPTU
2.86Single6DS0Ly2660976DS0-5-HT2B-Ly266097
2.86Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
2.86Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
2.86Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
2.86Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
2.86Single8Y72BMS-9861228Y72-μ-Peptide-BMS-986122-Gi1/β1/γ2
2.86Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
2.86Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
2.86Single9LRBHistamine9LRB-H1-Histamine-Gs/β1/γ2
2.78Single5O9HNDT95137275O9H-C5a1-NDT9513727
2.78Single6ZINSR486926ZIN-NTS1-SR48692
2.78Single7VODCariprazine7VOD-5-HT2A-Cariprazine
2.78Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ2
2.78Single8IYXYL-3658IYX-GPR34-YL-365
2.78Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
2.78Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
2.70Single4Z9GCP-3763954Z9G-CRF1-CP-376395
2.70Single6C1RAvacopan; Na6C1R-C5a1-PMX53-Avacopan; Na
2.70Single7RBTLSN35566727RBT-GIP-Tirzepatide-LSN3556672-chim(NtGi1-Gs)/β1/γ2
2.70Single8GTIBMK-C2058GTI-CRF1-BMK-C205
2.63Single8GTGBMK-I1528GTG-CRF1-BMK-I152
2.63Single8YYXLeukotriene e48YYX-Oxoglutarate-Leukotriene e4-chim(Gi1-CtGq)/β1/γ2
2.63Single9CM7AZ-17299CM7-FFA2-TUG-1375-AZ-1729-Gi1/β1/γ2
2.63Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
2.63Single9IYBA1D5Q9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
2.56Single8XXVA1D5Q8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
2.38Single5TZYMK8666; AP85TZY-FFA1-MK8666; AP8
2.33Single8XFTR-spondin-28XFT-LGR4-R-spondin-2-ZNRF3
2.33Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-ZNRF3
2.22Single8WVUR-spondin-18WVU-LGR4-R-spondin-1-RNF43
2.22Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-ZNRF3
2.17Single8XFPR-spondin-28XFP-LGR4-R-spondin-2-ZNRF3
2.04Single8XFSR-spondin-28XFS-LGR4-R-spondin-2-ZNRF3

Consensus Members
Id Members
6NBF 6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
8HA0 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
8HAF 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
7Y36 7Y36-PTH1-Teriparatide-Gs/β1/γ2
7Y35 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
Net Summary
Imin 2.65
Number of Linked Nodes 995
Number of Links 1279
Number of Hubs 222
Number of Links mediated by Hubs 844
Number of Communities 22
Number of Nodes involved in Communities 316
Number of Links involved in Communities 499
Path Summary
Number Of Nodes in MetaPath 102
Number Of Links MetaPath 101
Number of Shortest Paths 3164024
Length Of Smallest Path 3
Average Path Length 31.5172
Length of Longest Path 65
Minimum Path Strength 0.271
Average Path Strength 6.0725
Maximum Path Strength 21.202
Minimum Path Correlation 0.7
Average Path Correlation 0.990064
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.17391
Average % Of Corr. Nodes 48.7591
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 51.5554
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following consensuses:
IdComponents
pth_on_gppth1_on_gp
pth2_on_gp



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