Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
1NT 7.67751425
21x35 5.275425
31x39 3.581506
41x50 6.53688409
51x56 1.335407
6I1 3.42947
72x45 5.70156409
82x46 4.19187429
92x47 3.768509
102x50 5.435529
112x57 4.8795527
122x61 2.17125406
13E1x50 6.5795199
143x29 4.6275425
153x30 3.02813405
163x32 3.70125527
173x38 5.85375407
183x41 2.67406406
193x49 2.9425508
203x50 4.41792609
21E2 12.16211423
225x36 6.91031425
235x39 5.9405526
245x40 6.16042625
255x43 6.46688425
265x461 6.16937426
275x50 3.1725409
285x58 5.98521669
295x69 3.84875474
30I3 4.140451174
316x45 4.40589769
326x47 4.40656408
336x48 7.43725569
346x51 5.04031426
35E3 4.27771621
367x34 5.23225524
377x35 7.10344424
387x42 4.29125527
397x52 2.364694208
407x53 3.96125409
41G.HN.11 1.71225502
42G.S1.02 5.20725595
43G.S1.06 4.11455218
44G.S2.03 5.55469419
45G.S2.08 5.9405595
46G.S3.03 7.544597
47G.S3.04 8.22625416
48G.S3.06 7.71175515
49G.S3.07 3.858754219
50G.s3h2.03 4.57975519
51G.H2.02 3.96156418
52G.H2.03 6.1225419
53G.H2.04 3.70937409
54G.H2.06 5.13641819
55G.H2.07 4.41554719
56G.H2.09 6.03281418
57G.h2s4.01 6.58625519
58G.S4.02 4.27775518
59G.s4h3.04 6.6115128
60G.H3.01 6.50469409
61G.H3.09 6.02304719
62G.H3.13 3.82719415
63G.H3.14 4.81188408
64G.H3.17 8.035615
65G.H3.18 6.01969419
66G.S5.02 3.64281416
67G.S5.03 3.01375408
68G.S5.04 4.25125419
69G.S5.05 3.767589
70G.S5.06 5.87625408
71G.S5.07 3.78875489
72G.HG.03 3.462194126
73G.HG.04 4.88525509
74G.HG.07 4.464064129
75G.HG.14 2.82031405
76G.hgh4.02 6.245755157
77G.hgh4.05 7.22062407
78G.H4.03 5.78625614
79G.H4.15 4.93708618
80G.h4s6.02 4.73219418
81G.S6.02 6.38083677
82G.S6.05 4.231514
83G.s6h5.01 4.27575589
84G.s6h5.02 2.88407
85G.s6h5.05 3.13937489
86G.H5.03 6.32488
87G.H5.08 5.47844498
88G.H5.13 4.11188478
89G.H5.26 4.18969405
90b.1x1 1.43813401
91b.1x4 3.200634253
92b.h2x1 3.66125405
93b.h2x5 3.7775405
94b.lhb1x3 3.21344402
95b.lhb1x6 4.714694133
96b.b1x3 4.705314107
97b.l1x3 9.54925559
98b.b2x1 7.5445518
99b.b2x5 9.63625407
100b.l3x2 5.022559
101b.b4x3 3.911254177
102b.b4x5 4.371564147
103b.b4x6 8.94354659
104b.b5x2 6.00469407
105b.b5x3 6.50768759
106b.b5x5 5.669064145
107b.b5x7 5.55188407
108b.l5x1 4.430255178
109b.l5x5 6.91554719
110b.b6x5 3.919228146
111b.b7x1 5.473755244
112b.l7x2 4.53687419
113b.l7x4 3.09469409
114b.b8x3 3.663754246
115b.b8x4 5.4865176
116b.l8x1 3.494694145
117b.b9x4 6.43125409
118b.l9x3 6.85208619
119b.l9x6 5.07187818
120b.b10x5 4.21075509
121b.l10x1 3.83281403
122b.b11x4 5.33906419
123b.b11x5 4.87406436
124b.l11x2 7.81844419
125b.b12x3 3.45062438
126b.b12x6 8.87562618
127b.b12x7 4.15406439
128b.b13x7 7.952537
129b.l13x3 7.29083639
130b.l13x6 5.4835519
131b.l13x7 4.39437439
132b.b14x3 5.13063435
133b.b15x1 6.88525539
134b.b15x2 5.81562416
135b.b15x3 4.76469439
136b.l15x1 5.06575517
137b.l15x2 4.7925539
138b.b16x4 10.5066436
139b.b16x5 4.158505
140b.b16x6 8.67083638
141b.b17x4 5.534064185
142b.b17x5 6.41031417
143b.b17x7 9.06031418
144b.l17x3 8.96417619
145b.l17x6 6.24625519
146b.b18x3 4.62625518
147b.l18x1 6.127867166
148b.l18x2 4.927814167
149b.l18x3 7.015314165
150b.b19x2 6.61667616
151b.b19x4 6.15094418
152b.l19x1 6.16419
153b.l19x2 5.937519
154b.b20x4 9.54725518
155b.b20x6 7.7965516
156b.b21x1 7.66875517
157b.b21x5 4.78844404
158b.b21x7 6.226505
159b.l21x2 4.812814114
160b.l21x5 3.538134114
161b.b22x5 4.921886167
162b.l22x5 6.64155139
163b.b23x6 6.18757117
164b.l23x1 8.39281406
165b.b24x4 7.560634116
166b.b24x6 5.55254118
167b.l24x3 4.33031405
168b.b25x3 6.866884115
169b.l25x3 8.71475549
170b.b27x3 4.995448
171b.l28x1 10.4252719
172b.l28x2 7.97281449
173b.b28x3 4.54938457
174b.b28x4 7.70219446
175b.b28x6 7.17854649
176g.h2x11 7.941884166
177g.ctx3 5.988126139
178g.ctx6 3.38655136
179g.ctx14 5.763444109
180g.ctx15 5.714064109
181g.ctx16 4.596418108
182Lig 5.744041320
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1E2 Lig 13.02076.91125YesYes230
23x29 Lig 10.43312.97125YesYes250
36x48 7x41 28.63073.1YesNo098
46x51 7x41 28.40434.91375YesNo068
56x51 Lig 52.92348.95125YesYes260
63x43 7x53 41.44044.9825NoYes089
73x43 6x45 33.06143.655NoYes089
86x45 6x48 32.14093.71875YesYes699
95x47 6x45 29.57564.825NoYes089
105x47 6x52 28.909718NoNo087
116x51 6x52 28.2352.885YesNo067
123x50 5x58 36.49066.43YesYes099
135x54 5x58 33.11683.205NoYes689
145x54 6x45 33.33223.6525NoYes689
153x50 7x53 44.20953.75YesYes099
163x50 G.H5.25 82.67377.89375YesNo097
17G.H5.20 G.H5.25 82.94242.59625NoNo097
18G.H5.13 I3 82.61742.9525YesYes784
19G.H5.13 G.H5.17 84.26385.35375YesNo085
206x30 G.H5.17 84.08163.7425NoNo065
216x30 G.H5.26 83.9936.63625NoYes065
22G.H5.20 G.H5.26 83.21054.56875NoYes095
23G.S4.03 G.S5.03 10.70552.7575NoYes078
24G.H5.10 G.S5.03 16.52572.84375NoYes068
25G.H5.10 G.S6.02 16.76964.83625NoYes067
266x23 I3 91.4493.675NoYes724
276x23 6x26 99.60785.2175NoNo024
286x26 G.h4s6.08 99.75934.79625NoNo043
29E3 NT 12.63823.7675YesYes215
30G.h4s6.02 G.h4s6.08 1004.0225YesNo083
31G.h4s6.02 G.h4s6.11 29.57136.47125YesNo187
32G.S5.02 G.h4s6.11 29.68214.18125YesNo167
33G.S4.02 G.S5.02 60.60713.31125YesYes186
34G.H3.18 G.S4.02 23.80237.535YesYes198
35G.H3.15 G.H3.18 23.65754.3775NoYes189
36G.H3.15 G.H3.17 23.60766.92125NoYes185
37G.H3.17 b.l25x6 22.50164.625YesNo158
38b.l23x1 b.l25x6 32.760920.9925YesNo068
39b.l21x7 b.l23x1 28.33054.86NoYes056
40b.b23x6 b.l21x7 27.75383.19125YesNo1175
41b.b23x6 b.b24x6 26.21096.14875YesYes1178
42b.b21x7 b.b24x6 26.14366.8725YesYes058
43b.b21x5 b.b21x7 21.97299.28YesYes045
44b.b21x5 b.h2x1 21.36024.9475YesYes045
45b.h2x1 b.h2x5 20.71613.13375YesYes055
46b.h2x5 b.lhb1x3 10.07913.8YesYes052
47b.l22x5 g.ctx6 18.41244.0975YesYes1396
48g.ctx3 g.ctx6 17.58226.27625YesYes1396
49g.ctx3 g.ctx4 14.2924.22625YesNo097
50b.l27x5 g.ctx4 14.07397.7575NoNo057
51G.S6.01 G.h4s6.02 49.90545.485NoYes158
52G.S5.02 G.S6.01 29.57353.31125YesNo165
53G.H3.13 G.h4s6.02 20.60372.95YesYes158
54G.H3.09 G.H3.13 20.6145.58625YesYes195
55G.H3.09 G.S4.04 37.081715.0025YesNo099
56G.H3.08 G.S4.04 37.02695.025NoNo099
57G.H2.04 G.H3.08 37.00255.16YesNo099
58G.H2.04 G.H2.07 36.99313.75YesYes099
59G.H2.07 b.l9x6 78.41663.85875YesYes198
60b.l11x1 b.l9x6 23.94036.5175NoYes198
61b.b11x6 b.l11x1 25.37283.01625NoNo199
62b.b11x6 b.l9x3 24.380315.3437NoYes199
63b.b12x6 b.l9x3 23.12346.74375YesYes189
64b.b12x6 b.b9x4 22.530716.0863YesYes089
65b.b8x3 b.b9x4 22.09693.20875YesYes069
66b.b8x3 b.l12x1 19.77074.415YesNo066
67b.l10x4 b.l12x1 18.07094.955NoNo036
68b.b12x7 b.l10x4 17.75474.04YesNo393
69b.b12x7 b.b13x4 17.30462.89375YesNo394
70b.b12x5 b.b13x4 12.1384.0525NoNo364
71b.b11x1 b.b12x5 12.00254.49NoNo056
72b.b11x1 b.l10x1 11.71213.99125NoYes053
73b.b14x5 b.l10x1 11.59314.67125NoYes053
74b.b10x4 b.b14x5 11.45064.4025NoNo065
75b.b10x4 b.b2x4 11.312414.2463NoNo066
76b.b2x4 b.b6x5 11.19943.27NoYes066
77G.H3.09 G.S6.01 20.35663.61125YesNo195
78G.S1.05 G.S4.02 36.86274.45875NoYes198
79G.S1.05 G.h2s4.01 36.828210.3525NoYes199
80G.H2.07 G.h2s4.01 39.12573.885YesYes199
81G.H2.06 b.l9x6 63.51634.3275YesYes198
82G.H2.06 b.l17x6 31.40687.60625YesYes199
83G.H2.06 b.l19x1 31.38112.93875YesYes199
84b.l3x1 b.l5x5 11.50116.02625NoYes199
85b.b2x1 b.l3x1 11.112212.6825YesNo189
86b.b2x1 b.l28x1 10.76847.4775YesYes189
87b.l17x5 b.l17x6 32.85063.68125NoYes169
88b.l17x5 b.l19x2 63.79642.94375NoYes169
89b.l17x3 b.l19x2 44.36854.2525YesYes199
90b.b19x4 b.l17x3 25.25768.72875YesYes189
91b.b19x4 b.b20x6 16.87217.135YesYes186
92b.b17x7 b.b20x6 46.738210.985YesYes186
93b.b17x7 b.b21x1 42.88236.12YesYes187
94b.1x18 b.b21x1 33.38197.74125NoYes067
95b.1x14 b.1x18 29.50682.6625NoNo076
96b.1x11 b.1x14 27.56892.15NoNo067
97b.1x11 g.h1x11 26.59982.265NoNo069
98b.1x10 g.h1x11 24.66153.2875NoNo089
99b.1x10 g.h1x12 23.69222.99625NoNo086
100g.h1x12 g.h1x9 21.75354.725NoNo066
101g.h1x5 g.h1x9 20.7843.63375NoNo066
102g.h1x1 g.h1x5 18.02811.41NoNo026
103b.1x1 g.h1x1 16.24140.8925YesNo012
104b.l17x5 b.l19x1 31.26174.78375NoYes169
105b.b20x4 b.l17x3 17.83517.9125YesYes189
106b.b20x4 b.b20x6 33.73845.0775YesYes186
107b.b20x2 b.l19x2 18.47439.21375NoYes069
108b.b20x2 b.b20x4 17.83515.985NoYes068
109b.l25x6 b.l28x1 10.348819.99NoYes189
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
E2NT18.15622YesYes3512
E2x51NT5.176252NoYes4522
NTNT18.01632YesYes5522
6x58NT3.612NoYes5512
7x34NT10.31632YesYes4512
3x29NT5.092YesYes5512
2x60NT5.408752NoYes6522
7x38NT4.09752NoYes5522
2x533x323.821252NoYes7721
2x537x426.778752NoYes7722
2x603x325.152NoYes6721
E1E22.90NoYes4321
3x283x293.350NoYes6521
3x294x657.098752YesNo5512
3x327x423.3252YesYes7712
3x32Lig4.143752YesYes7010
3x334x614.05250NoNo5512
3x33Lig9.64250NoYes5010
3x375x433.052NoYes6521
3x375x4618.282NoYes6622
4x605x397.631250NoYes8612
4x615x394.41250NoYes5622
4x64E28.628752NoYes5321
4x65E2x527.460NoNo5522
E2E243.41372YesYes3311
E2E2x516.30752YesNo3412
E2E2x529.793752YesNo3512
5x36E214.17382YesYes5311
5x39E24.333752YesYes6321
E2Lig6.911252YesYes3010
5x365x403.963752YesYes5511
5x366x625.752YesNo5012
5x36Lig3.753752YesYes5010
5x395x403.491252YesYes6521
5x395x439.833752YesYes6521
5x406x557.493752YesNo5511
5x406x596.446252YesNo5412
5x40Lig11.30252YesYes5010
5x435x4617.588752YesYes5612
5x43Lig5.3952YesYes5010
6x516x522.8852YesNo6712
6x517x414.913752YesNo6812
6x51Lig8.951252YesYes6010
6x55Lig7.038752NoYes5010
6x58Lig5.042NoYes5010
7x347x383.42752YesNo4512
7x34Lig5.5452YesYes4010
7x387x423.152NoYes5722
3x26E22.940NoYes7321
3x29Lig2.971252YesYes5010
5x32E24.998752NoYes0321
6x516x553.411252YesNo6511
4x60Lig3.17750NoYes8010
5x407x344.2652YesYes5411
3x22E22.718752NoYes3321
6x547x342.60750NoYes5421
4x594x602.450NoNo5821
2x563x322.066250NoYes6721
E1x49E21.582NoYes5321
5x35Lig0.80NoYes3010

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
73.33Consensusffa4_onOrthosteric Ligand8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
64.29Consensusffa2_onOrthosteric Ligand8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
62.50Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
60.00Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
60.00Consensusffa_onOrthosteric Ligandffa4_on ffa1_on ffa2_on ffa3_on
60.00Consensusp2y12_offOrthosteric Ligand4NTJ-P2Y12-AZD1283 7PP1-P2Y12-Selatogrel
57.14Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
56.25Single8ID9Eicosapentaenoic acid8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
55.56Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
55.56Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
53.85Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
53.85Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
52.94Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
52.63Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
50.00Single4PY02MeSATP4PY0-P2Y12-2MeSATP
50.00Single7Y24Octreotide7Y24-SST2-Octreotide-Go/&β;1/&γ;2
50.00Single8G59TUG-8918G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
50.00Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
47.37Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
47.37Single8ID8TUG-8918ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
47.37Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
47.37Consensusffa4_on_alloOrthosteric Ligand8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
47.06Single4NTJAZD12834NTJ-P2Y12-AZD1283
47.06Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
47.06Single7CKXA776367CKX-D1-A77636-Gs/&β;1/&γ;2
47.06Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
47.06Single8QOTNanobody E8QOT-μ-Nanobody E
46.67Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
46.67Consensusffa3_on_alloOrthosteric Ligand8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
45.45Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
45.00Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
44.44Single4RWADIPP-NH24RWA-δ-DIPP-NH2
44.44Single6J21Aprepitant6J21-NK1-Aprepitant
44.44Single7JV5SKF812977JV5-D1-SKF81297-Gs/&β;1/&γ;2
44.44Single7JVPSKF839597JVP-D1-SKF83959-Gs/&β;1/&γ;2
44.44Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
44.44Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
44.44Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
44.44Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
44.44Consensus5ht1b_onOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
44.44Consensuscyslt1_off_ortoalloOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
44.44Consensusgs_compl-peptideOrthosteric Ligand8I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
43.75Single4DKLBeta-funaltrexamine4DKL-μ-Beta-funaltrexamine
43.75Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
43.75Single7JOZVFP7JOZ-D1-VFP-Gs/&β;1/&γ;2
43.75Single8K4NVF08K4N-GPR34-VF0-Gi1/&β;1/&γ;2
43.75Consensusdop_off_alloOrthosteric Ligand4N6H-δ-Naltrindole-Na
43.48Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
42.86Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
42.86Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
42.86Consensusmop_offOrthosteric Ligand7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
42.11Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
42.11Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/&β;1/&γ;2
42.11Single7YITNalfurafine7YIT-κ-Nalfurafine
42.11Single8I95EP548I95-C3aB-EP54-Go/&β;1/&γ;2
42.11Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
42.11Single8WU1KCA8WU1-CB1-KCA-Arrestin1
42.11Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
42.11Consensusopioid_offOrthosteric Ligandkop_off mop_off nop_off dop_off
42.11Consensuspeptide_offOrthosteric Ligandopioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
41.18Single4EJ4Naltrindole4EJ4-δ-Naltrindole
41.18Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
41.18Single7CRHSKF839597CRH-D1-SKF83959-Gs/&β;1/&γ;2
41.18Single7LJCPubChem 867641037LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
41.18Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
41.18Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
41.18Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
40.91Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
40.00Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
40.00Single6DDFDamgo6DDF-μ-Damgo-Gi1/&β;1/&γ;2
40.00Single6HLLCP999946HLL-NK1-CP99994
40.00Single6QNOAll-trans-retinal6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
40.00Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
40.00Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
40.00Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2
40.00Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
40.00Single8EF6Morphine8EF6-μ-Morphine-Gi1/&β;1/&γ;2
40.00Single8WRZ8D08WRZ-CB1-8D0-Arrestin1
39.13Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
38.89Single5N2SPSB365N2S-A1-PSB36
38.89Single6DDEDamgo6DDE-μ-Damgo-Gi1/&β;1/&γ;2
38.89Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
38.89Single7CFNINT-7777CFN-GPBA-INT-777-Gs/&β;1/&γ;2
38.89Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
38.89Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
38.89Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
38.89Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
38.89Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
38.89Single7Y27Somatostatin-147Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
38.89Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
38.89Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
38.89Single8DZQmomSalB8DZQ-κ-momSalB-Go/&β;1/&γ;2
38.89Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
38.89Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
38.89Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
38.89Consensusa1_on_alloOrthosteric Ligand7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
38.89Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRR-D1-Rotigotine-Gs/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
38.89Consensusgo_opioidOrthosteric Ligand8DZQ-κ-momSalB-Go/&β;1/&γ;2
38.89Consensusgs_sstOrthosteric Ligand7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
38.10Single3NY9PubChem 9131033NY9-β2-PubChem 913103
38.10Single6PT3DPI-2876PT3-δ-DPI-287
38.10Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
38.10Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
38.10Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
38.10Single8SAI1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
38.10Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
38.10Consensuslpl_offOrthosteric Ligands1p_off lpa_off
38.10Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
37.50Single2X72All-trans-retinal2X72-Rhodopsin-All-trans-retinal-Gt(CT)
37.50Single3VGAZM2413853VGA-A2A-ZM241385-Antibody
37.50Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
37.50Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
37.50Single7TUZ7alpha,25-dihydroxycholesterol7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
37.50Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
37.50Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
37.50Single8GGFEpinephrine8GGF-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
37.50Consensusgi_somatostatinOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
37.50Consensusp2y_offOrthosteric Ligandp2y1_off p2y12_off
37.04Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
36.84Single3SN6BI1671073SN6-β2-BI167107-Gs/&β;1/&γ;2
36.84Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
36.84Single5XRAAM115425XRA-CB1-AM11542
36.84Single6E59L-7607356E59-NK1-L-760735
36.84Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
36.84Single6J20Aprepitant6J20-NK1-Aprepitant
36.84Single7CKYPW04647CKY-D1-PW0464-Gs/&β;1/&γ;2
36.84Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
36.84Single7WV9PubMed 1048957WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
36.84Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
36.84Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/&β;1/&γ;2
36.84Single8E0GBU728E0G-μ-BU72
36.84Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
36.84Consensusa2_onOrthosteric Liganda2a_on a2b_on
36.84Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2
36.84Consensusgs_ffaOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2 8GDB-EP4-PGE2-Gs/&β;1/&γ;2
36.84Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
36.84Consensuslpa_offOrthosteric Ligandlpa1_off
36.84Consensuslpa_onOrthosteric Ligandlpa1_on
36.84Consensusnk1_offOrthosteric Ligand6J20-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
36.36Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
36.36Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
36.36Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
36.36Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
36.36Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
36.36Consensussst2_onOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
36.36Consensussst_onOrthosteric Ligandsst2_on sst4_on
36.00Single7KH0Acyclovir triphosphate7KH0-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
36.00Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
35.29Single4MBSMaraviroc4MBS-CCR5-Maraviroc
35.29Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
35.29Single6TPNHTL66416TPN-OX2-HTL6641
35.29Single7AROLUF58337ARO-A2A-LUF5833-Na
35.29Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/&β;1/&γ;2
35.29Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
35.29Single7F0TDopamine7F0T-D1-Dopamine-Gs/&β;1/&γ;2
35.29Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/&β;1/&γ;2
35.29Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
35.29Single8GURPubChem 1048958GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2
35.29Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
35.29Single8HQN9(S)-HODE8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
35.29Single8UO2Epinephrine8UO2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.29Consensusd1_on_alloOrthosteric Ligand7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
35.29Consensusox2_offOrthosteric Ligand6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant
35.00Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
35.00Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
35.00Single6HLPNetupitant6HLP-NK1-Netupitant
35.00Single6MXTSalmeterol6MXT-β2-Salmeterol
35.00Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
35.00Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2
35.00Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
35.00Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
35.00Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
35.00Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
35.00Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
35.00Single7Y66BM2137Y66-C5a1-BM213-Gi1/&β;1/&γ;2
35.00Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2
35.00Single8IJDMK68928IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
35.00Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
35.00Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
35.00Consensusgo_5htOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
35.00Consensusgs_trhOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
35.00Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
35.00Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
34.78Single3QAKUK-4320973QAK-A2A-UK-432097
34.78Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
34.78Single6HLOAprepitant6HLO-NK1-Aprepitant
34.78Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/&β;1/&γ;2
34.78Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
34.78Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
34.78Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
34.78Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
34.78Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
34.78Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
34.62Consensusgi_neuromedinOrthosteric Ligand7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
34.62Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
34.48Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
33.33Single3OE0CVX153OE0-CXCR4-CVX15
33.33Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
33.33Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
33.33Single5UENDU1725UEN-A1-DU172
33.33Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
33.33Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
33.33Single6PT2KGCHM076PT2-δ-KGCHM07
33.33Single6W25SHU91196W25-MC4-SHU9119-Ca
33.33Single7CFMP3957CFM-GPBA-P395-Gs/&β;1/&γ;2
33.33Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
33.33Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
33.33Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
33.33Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1
33.33Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
33.33Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
33.33Single7S8O(R)-Zinc-35737S8O-MRGPRX2-(R)-Zinc-3573-Gi1/&β;1/&γ;2
33.33Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/&β;1/&γ;2
33.33Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
33.33Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
33.33Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
33.33Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
33.33Single7V3ZPubMed 1048957V3Z-CB1-PubMed 104895
33.33Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
33.33Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/&β;1/&γ;2
33.33Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
33.33Single7XK2MK68927XK2-HCA2-MK6892-Gi1/&β;1/&γ;2
33.33Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
33.33Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
33.33Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
33.33Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
33.33Single8CU6LJ-45178CU6-A2A-LJ-4517
33.33Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
33.33Single8EITDoconexent8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
33.33Single8EJCTAK-8758EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
33.33Single8GEHEpinephrine8GEH-β2-Epinephrine-Gs/&β;1/&γ;2
33.33Single8JLZST19368JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
33.33Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
33.33Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
33.33Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
33.33Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
33.33Consensusadenosine_onOrthosteric Liganda1_on a2_on
33.33Consensuscb1_on_alloOrthosteric Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
33.33Consensuscck_offOrthosteric Ligandccka_off
33.33Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
33.33Consensusendothelin_onOrthosteric Ligandetb_on eta_on
33.33Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
33.33Consensusgs_orexinOrthosteric Ligand7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
33.33Consensusnucleotide_onOrthosteric Ligandadenosine_on
33.33Consensusorexin_onOrthosteric Ligandox2_on
33.33Consensustachykinin_offOrthosteric Ligandnk1_off
32.14Single6IGLIRL16206IGL-ETB-IRL1620
32.14Single8FEGPRD_0025178FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
32.14Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
32.14Single8IY6Endothelin-18IY6-ETB-Endothelin-1
32.14Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
32.14Consensusgs_endothelinOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
32.14Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
32.00Single7C61Ergotamine7C61-5-HT1B-Ergotamine
32.00Consensusnmur_onOrthosteric Ligandnmur1_on nmur2_on
31.82Single4UG2CGS216804UG2-A2A-CGS21680
31.82Single5ZTYAM102575ZTY-CB2-AM10257
31.82Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
31.82Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
31.82Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
31.82Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
31.82Single7XN9L-054,5227XN9-SST2-L-054,522
31.82Single7XY6PubChem 117178317XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
31.82Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
31.82Single8IYHMK68928IYH-HCA2-MK6892-Go/&β;1/&γ;2
31.82Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.82Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2 8I95-C3aB-EP54-Go/&β;1/&γ;2
31.82Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
31.82Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
31.82Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
31.82Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
31.82Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
31.82Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
31.82Consensuslpl_onOrthosteric Ligands1p_on lpa_on
31.82Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
31.58Single4PHUFasiglifam4PHU-FFA1 (GPR40)-Fasiglifam
31.58Single5C1MBU725C1M-μ-BU72
31.58Single5N2RPubChem 92460631; psb365N2R-A2A-PubChem 92460631; psb36-Na
31.58Single5NM2ZM2413855NM2-A2A-ZM241385-Na
31.58Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
31.58Single5X7D(S)-Carazolol5X7D-β2-(S)-Carazolol-PubChem 129318963
31.58Single5XPRBosentan5XPR-ETB-Bosentan
31.58Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
31.58Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
31.58Single7SBFPZM217SBF-μ-PZM21-Gi1/&β;1/&γ;2
31.58Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
31.58Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
31.58Single7WC6LSD7WC6-5-HT2A-LSD
31.58Single7XKAEpinephrine7XKA-β2-Epinephrine
31.58Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
31.58Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
31.58Single8GNEKW-63568GNE-A2A-KW-6356-Na
31.58Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
31.58Single8UNYEpinephrine8UNY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
31.58Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.58Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
31.58Consensusadrenergic_offOrthosteric Ligandbeta_off alpha_off
31.58Consensuscb2_onOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
31.25Single3PBLEticlopride3PBL-D3-Eticlopride
31.25Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
31.25Single6TP4ACT-4622066TP4-OX1-ACT-462206
31.25Single7S8N(R)-Zinc-35737S8N-MRGPRX2-(R)-Zinc-3573-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
31.25Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
31.25Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/&β;1/&γ;2
31.25Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2
31.25Single8GH1Epinephrine8GH1-β2-Epinephrine
31.25Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
31.25Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
31.25Consensusox1_off_alloOrthosteric Ligand6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na 6TO7-OX1-Suvorexant-Na
31.03Single5GLHEndothelin-15GLH-ETB-Endothelin-1
31.03Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
30.77Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
30.77Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
30.77Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
30.77Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
30.77Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
30.77Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.77Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
30.77Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
30.77Single8WCCCyclohexylammonium ion8WCC-TA1-Cyclohexylammonium ion
30.77Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
30.77Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.77Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
30.77Consensusgs_melanocortinOrthosteric Ligand7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2
30.77Consensusgs_neuromedinOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.77Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
30.43Single4IARErgotamine4IAR-5-HT1B-Ergotamine
30.43Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
30.43Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
30.43Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
30.43Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.43Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
30.43Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
30.43Single8GHVPubChem 1459649038GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
30.43Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
30.43Single8J6RMK68928J6R-HCA2-MK6892-Gi1/&β;1/&γ;2
30.43Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
30.43Consensusfpr-alx_onOrthosteric Ligandfpr1-alx_on fpr2-alx_on
30.43Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
30.43Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
30.00Single2YDVNECA2YDV-A2A-NECA
30.00Single3P0GBI1671073P0G-β2-BI167107
30.00Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
30.00Single4UHRCGS216804UHR-A2A-CGS21680
30.00Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
30.00Single5G53NECA5G53-A2A-NECA-Gs
30.00Single5TZR-5TZR-FFA1 (GPR40)-MK8666
30.00Single5X93K-87945X93-ETB-K-8794
30.00Single5XR8AM8415XR8-CB1-AM841
30.00Single6H7JIsoprenaline6H7J-β1-Isoprenaline
30.00Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
30.00Single6NI3BI1671076NI3-β2-BI167107-Gs/&β;1/&γ;2
30.00Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
30.00Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
30.00Single7EW7PubChem 40774607EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
30.00Single7FEEPubMed 1048957FEE-CB1-PubMed 104895-ZCZ011
30.00Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2
30.00Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
30.00Single7TUYGSK682753A7TUY-GPR183-GSK682753A
30.00Single7W41PD1762527W41-BB2-PD176252
30.00Single7XTQR3997XTQ-GPBA-R399-Gs/&β;1/&γ;2
30.00Single8DZPmomSalB8DZP-κ-momSalB-Gi1/&β;1/&γ;2
30.00Single8FMZNeurotensin/neuromedin N8FMZ-NTS1-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
30.00Single8GUSHU-3088GUS-CB2-HU-308-Gi1/&β;1/&γ;2
30.00Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
30.00Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
30.00Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
30.00Single8JXVClozapine8JXV-H4-Clozapine-Gi1/&β;1/&γ;2
30.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
30.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
30.00Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
30.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
30.00Consensus5ht5_offOrthosteric Ligand5ht5a_off
30.00Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
30.00Consensusadenosine_offOrthosteric Liganda1_off a2_off
30.00Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
30.00Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
30.00Consensusbombesin_offOrthosteric Ligandbb2_off
30.00Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
30.00Consensusgi_dopamineOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
30.00Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
30.00Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A2A-NECA-Gs/&β;1/&γ;1 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
30.00Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
30.00Consensusnts1_on_alloOrthosteric Ligand8JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
30.00Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
30.00Consensussst4_onOrthosteric Ligand7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
29.63Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.63Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
29.63Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
29.41Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
29.41Single3PWHZM2413853PWH-A2A-ZM241385
29.41Single5K2DZM2413855K2D-A2A-ZM241385
29.41Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
29.41Single5WS3EMPA5WS3-OX2-EMPA
29.41Single6AKXA4R6AKX-CCR5-A4R
29.41Single6AKYMaraviroc6AKY-CCR5-Maraviroc
29.41Single6B73PubChem 1319551386B73-κ-PubChem 131955138
29.41Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/&β;1/&γ;2
29.41Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
29.41Single6JZHZM2413856JZH-A2A-ZM241385-Na
29.41Single6NWEOctyl Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
29.41Single6PS7ZM2413856PS7-A2A-ZM241385-Na
29.41Single6TODEMPA6TOD-OX1-EMPA-Na
29.41Single7BR3Elagolix7BR3-GnRH1-Elagolix
29.41Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/&β;1/&γ;2
29.41Single7F8ULintitript7F8U-CCKA-Lintitript
29.41Single7F8YDevazepide7F8Y-CCKA-Devazepide
29.41Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
29.41Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
29.41Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
29.41Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
29.41Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2
29.41Single7XRRLemborexant7XRR-OX2-Lemborexant
29.41Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
29.41Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
29.41Single8EFOPZM218EFO-μ-PZM21-Gi1/&β;1/&γ;2
29.41Single8GNGIstradefylline8GNG-A2A-Istradefylline
29.41Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
29.41Single8UO0Epinephrine8UO0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
29.41Single8UO3Epinephrine8UO3-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
29.41Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
29.41Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
29.41Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
29.41Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
29.41Consensusa2a_off_alloOrthosteric Ligand6ZDR-A2A-HMS1413f12-Na 6GT3-A2A-Imaradenant-Na 8CU7-A2A-LJ-4517-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PubChem 92460631; psb36-Na 5MZJ-A2A-Theophylline-Na 5OLO-A2A-Tozadenant-Na 5OLH-A2A-Vipadenant-Na 5NM4-A2A-ZM241385-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5MZP-A2A-Caffeine-Na 8CIC-A2A-Etrumadenant-Na
29.41Consensusgi_nucleotideOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
29.41Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
29.41Consensusgs_5htOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2 7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2 7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
29.41Consensusmelatonin_onOrthosteric Ligandmt1_on mt2_on
29.41Consensusorexin_offOrthosteric Ligandox2_off ox1_off
29.17Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
29.17Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
29.17Consensuscx3cr_onOrthosteric Ligandcx3cr1_on
29.17Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
29.03Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
28.57Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
28.57Single4LDEBI1671074LDE-β2-BI167107
28.57Single6KQIPubMed 1048956KQI-CB1-PubMed 104895-ORG27569
28.57Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
28.57Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/&β;1/&γ;2
28.57Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
28.57Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
28.57Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/&β;1/γ1
28.57Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.57Single7XMTJ-21567XMT-SST4-J-2156-Gi1/&β;1/&γ;2
28.57Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
28.57Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
28.57Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
28.57Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2
28.57Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
28.57Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
28.57Single8JJ8Formoterol8JJ8-β2-Formoterol
28.57Single8JJLOlodaterol8JJL-β2-Olodaterol
28.57Single8JPBNeurotensin 8-138JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
28.57Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/&β;1/&γ;2
28.57Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
28.57Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
28.57Consensuscannabinoid_onOrthosteric Ligandcb1_on cb2_on
28.57Consensuscb1_off_alloOrthosteric Ligand6KQI-CB1-PubMed 104895-ORG27569
28.57Consensuscb1_onOrthosteric Ligand8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
28.57Consensusetb_onOrthosteric Ligand8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
28.57Consensusgi_cannabinoidOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
28.57Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
28.57Consensusgs_bileacidOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
28.57Consensusgs_steroidOrthosteric Ligandgs_bileacid
28.57Consensusleuko_offOrthosteric Ligandblt_off cyslt_off
28.57Consensusnts1_offOrthosteric Ligand6Z4Q-NTS1-SR142948A 6Z4S-NTS1-SR48692
28.57Consensusnts_offOrthosteric Ligandnts1_off
28.57Consensustsh_on_alloOther Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
28.12Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
28.12Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
28.12Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
28.12Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
28.00Single5WF5UK-4320975WF5-A2A-UK-432097
28.00Single7F4DAlpha-MSH7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
28.00Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
28.00Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;2
28.00Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
28.00Consensusangiotensin_onOrthosteric Ligandat1_on
28.00Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
28.00Consensuscx3cr1_onOrthosteric Ligand7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
28.00Consensusgi_formylpeptideOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
28.00Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
28.00Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
27.78Single3UZCPubChem 1355666093UZC-A2A-PubChem 135566609
27.78Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
27.78Single4ZJCSB-6740424ZJC-OX1-SB-674042
27.78Single5IU4ZM2413855IU4-A2A-ZM241385-Na
27.78Single5IU7Q274563465IU7-A2A-Q27456346-Na
27.78Single5IUBQ274563445IUB-A2A-Q27456344-Na
27.78Single5JTBZM2413855JTB-A2A-ZM241385
27.78Single5K2CZM2413855K2C-A2A-ZM241385-Na
27.78Single5NLXZM2413855NLX-A2A-ZM241385-Na
27.78Single5NM4ZM2413855NM4-A2A-ZM241385-Na
27.78Single5TE3Octyl Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
27.78Single5UVIZM2413855UVI-A2A-ZM241385
27.78Single6AQFZM2413856AQF-A2A-ZM241385
27.78Single6IQLL7458706IQL-D4-L745870
27.78Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
27.78Single6MH8ZM2413856MH8-A2A-ZM241385
27.78Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
27.78Single6PS4ICI 118-5516PS4-β2-ICI 118-551
27.78Single6PS5(S)-Propranolol6PS5-β2-(S)-Propranolol
27.78Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
27.78Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
27.78Single6TPGEMPA6TPG-OX2-EMPA
27.78Single6TPKRetosiban6TPK-OT-Retosiban
27.78Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
27.78Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
27.78Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
27.78Single7CMVPD1289077CMV-D3-PD128907-Gi1/&β;1/&γ;2
27.78Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
27.78Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
27.78Single7VV6C48/807VV6-MRGPRX2-C48/80
27.78Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
27.78Single8GDZEpinephrine8GDZ-β2-Epinephrine-Gs/&β;1/&γ;2
27.78Single8GEGEpinephrine8GEG-β2-Epinephrine-Gs/&β;1/&γ;2
27.78Single8GGKEpinephrine8GGK-β2-Epinephrine
27.78Single8GGLEpinephrine8GGL-β2-Epinephrine
27.78Single8GGMEpinephrine8GGM-β2-Epinephrine
27.78Single8GGPEpinephrine8GGP-β2-Epinephrine
27.78Single8GGQEpinephrine8GGQ-β2-Epinephrine
27.78Single8GGTEpinephrine8GGT-β2-Epinephrine
27.78Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2
27.78Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
27.78Single8T3VDHA8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
27.78Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
27.78Single8UNZEpinephrine8UNZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
27.78Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
27.78Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
27.78Consensus5ht5_onOrthosteric Ligand5ht5a_on
27.78Consensus5ht5a_onOrthosteric Ligand7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
27.78Consensusd3_onOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
27.78Consensusgi_melatoninOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
27.78Consensusgnrh_offOrthosteric Ligandgnrh1_off
27.78Consensusgs_tarOrthosteric Ligand8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
27.78Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
27.78Consensusox1_offOrthosteric Ligand6TOT-OX1-Lemborexant 6TP4-OX1-ACT-462206 6TP6-OX1-Filorexant 6V9S-OX1-GTPL11403 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ7-OX1-SB-334867 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant
27.78Consensusvasopressin-ot_offOrthosteric Ligandot_off
27.59Single7VGXNeuropeptide Y7VGX-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
27.59Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
27.27Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
27.27Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
27.27Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
27.27Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
27.27Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
27.27Single7EZCUKA7EZC-A2A-UKA
27.27Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2
27.27Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
27.27Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
27.27Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.27Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
27.27Single7UM4AS26747237UM4-5-HT5A-AS2674723
27.27Single7XJISolabegron7XJI-β3-Solabegron-Gs/&β;1/&γ;2
27.27Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
27.27Single8E9YPubChem 4466038E9Y-M3-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
27.27Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
27.27Single8GAGYVF8GAG-CB1-YVF-Gi1/&β;1/&γ;2
27.27Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/&β;1/&γ;2
27.27Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
27.27Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
27.27Consensus5ht5a_offOrthosteric Ligand7UM4-5-HT5A-AS2674723
27.27Consensusbeta1_off_alloOrthosteric Ligand4BVN-β1-Cyanopindolol-Na
27.27Consensusbileacid_onOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
27.27Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
27.27Consensuscyslt2_offOrthosteric Ligand6RZ6-CysLT2-ONO-2570366 6RZ9-CysLT2-ONO-2770372 6RZ8-CysLT2-ONO-2080365
27.27Consensuscyslt_offOrthosteric Ligandcyslt2_off
27.27Consensusendothelin_offOrthosteric Ligandetb_off
27.27Consensusetb_offOrthosteric Ligand5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500 5X93-ETB-K-8794
27.27Consensusgi_neurotensinOrthosteric Ligand7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
27.27Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
27.27Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
27.27Consensussteroid_onOrthosteric Ligandbileacid_on
26.92Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
26.92Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
26.92Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
26.92Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
26.92Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
26.92Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
26.92Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
26.92Single8IHFMK68928IHF-HCA2-MK6892-Gi1/&β;1/&γ;2
26.92Single8J6IMK68928J6I-HCA2-MK6892-Gi1/&β;1/&γ;2
26.92Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
26.92Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
26.92Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
26.92Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
26.92Consensusnmur2_onOrthosteric Ligand7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.92Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
26.67Single3RFMCaffeine3RFM-A2A-Caffeine
26.67Single6IGKEndothelin-36IGK-ETB-Endothelin-3
26.67Single8A2OTheophylline8A2O-A2A-Theophylline-Na
26.32Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
26.32Single2Y02Carmoterol2Y02-β1-Carmoterol
26.32Single2Y04Salbutamol2Y04-β1-Salbutamol
26.32Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
26.32Single3EMLZM2413853EML-A2A-ZM241385
26.32Single3NY8ICI 118-5513NY8-β2-ICI 118-551
26.32Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
26.32Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
26.32Single4EIYZM2413854EIY-A2A-ZM241385-Na
26.32Single4GBR(S)-Carazolol4GBR-β2-(S)-Carazolol
26.32Single4X1HNonyl Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
26.32Single5IU8Q274563475IU8-A2A-Q27456347-Na
26.32Single5JQH(S)-Carazolol5JQH-β2-(S)-Carazolol
26.32Single5K2AZM2413855K2A-A2A-ZM241385-Na
26.32Single5OLGZM2413855OLG-A2A-ZM241385-Na
26.32Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
26.32Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
26.32Single5UIGJ3.651.884G5UIG-A2A-J3.651.884G
26.32Single5VRAZM2413855VRA-A2A-ZM241385-Na
26.32Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
26.32Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
26.32Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2
26.32Single6LPJZM2413856LPJ-A2A-ZM241385-Na
26.32Single6LPKZM2413856LPK-A2A-ZM241385-Na
26.32Single6PRZ(S)-Alprenolol6PRZ-β2-(S)-Alprenolol
26.32Single6PS0(S)-Carazolol6PS0-β2-(S)-Carazolol
26.32Single6PS1Timolol6PS1-β2-Timolol
26.32Single6PS2(S)-Alprenolol6PS2-β2-(S)-Alprenolol
26.32Single6S0LZM2413856S0L-A2A-ZM241385
26.32Single6TOTLemborexant6TOT-OX1-Lemborexant
26.32Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
26.32Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
26.32Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
26.32Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
26.32Single7BU7BI1671077BU7-β1-BI167107
26.32Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
26.32Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
26.32Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
26.32Single7PYRPSB-21157PYR-A2A-PSB-2115
26.32Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
26.32Single7SCGFH2107SCG-μ-FH210-Gi1/&β;1/&γ;2
26.32Single7UL4Alvimopan7UL4-μ-Alvimopan
26.32Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2
26.32Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
26.32Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
26.32Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
26.32Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
26.32Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
26.32Single8EJKTAK-8758EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
26.32Single8GE3Epinephrine8GE3-β2-Epinephrine-Gs/&β;1/&γ;2
26.32Single8GEBEpinephrine8GEB-β2-Epinephrine-Gs/&β;1/&γ;2
26.32Single8GEEEpinephrine8GEE-β2-Epinephrine-Gs/&β;1/&γ;2
26.32Single8GFWEpinephrine8GFW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
26.32Single8GFXEpinephrine8GFX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
26.32Single8GFYEpinephrine8GFY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
26.32Single8GFZEpinephrine8GFZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
26.32Single8GG0Epinephrine8GG0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
26.32Single8GG1Epinephrine8GG1-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
26.32Single8GG2Epinephrine8GG2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
26.32Single8GG6Epinephrine8GG6-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
26.32Single8GGBEpinephrine8GGB-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
26.32Single8GGJEpinephrine8GGJ-β2-Epinephrine
26.32Single8GGNEpinephrine8GGN-β2-Epinephrine
26.32Single8GGOEpinephrine8GGO-β2-Epinephrine
26.32Single8GGUEpinephrine8GGU-β2-Epinephrine
26.32Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
26.32Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2
26.32Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/&β;1/&γ;2
26.32Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
26.32Single8UNMEpinephrine8UNM-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
26.32Single8UNNEpinephrine8UNN-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
26.32Single8UNPEpinephrine8UNP-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
26.32Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
26.32Single8X64Desloratadine8X64-H1-Desloratadine
26.32Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
26.32Consensusa2_offOrthosteric Liganda2a_off
26.32Consensusa2a_offOrthosteric Ligand8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 5UIG-A2A-J3.651.884G 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-PubChem 168451710 5K2D-A2A-ZM241385
26.32Consensusadrenergic_onOrthosteric Ligandbeta_on alpha_on
26.32Consensusalpha2_onOrthosteric Ligandalpha2a_on alpha2b_on
26.32Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
26.32Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
26.32Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
26.32Consensusdopamine_onOrthosteric Ligandd3_on d2_on d5_on d1_on
26.32Consensusffa1_onOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.32Consensusgi_5htOrthosteric Ligand7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
26.32Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
26.32Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
26.32Consensustar_onOrthosteric Ligandta1_on
26.09Single5WF6UK-4320975WF6-A2A-UK-432097
26.09Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.09Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
26.09Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
26.09Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
26.09Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
26.09Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
26.09Single8XZFWN5618XZF-Apelin-WN561-Gi1/&β;1/&γ;2
26.09Consensusclass-d_offOrthosteric Ligandste2_off
26.09Consensusfpr2-alx_onOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
26.09Consensusgo_vasopressinOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
26.09Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.93Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.93Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.93Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
25.93Consensusgs_bradykininOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.81Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
25.00Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
25.00Single2RH1(S)-Carazolol2RH1-β2-(S)-Carazolol
25.00Single2Y03Isoprenaline2Y03-β1-Isoprenaline
25.00Single2YCW(S)-Carazolol2YCW-β1-(S)-Carazolol
25.00Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
25.00Single5D6L(S)-Carazolol5D6L-β2-(S)-Carazolol
25.00Single5IUAQ274563485IUA-A2A-Q27456348-Na
25.00Single5TVNLSD5TVN-5-HT2B-LSD
25.00Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
25.00Single5WKTOctyl Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
25.00Single5WQCEMPA5WQC-OX2-EMPA
25.00Single6E67BI1671076E67-β2-BI167107-Gs (fused)
25.00Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
25.00Single6FUFAll-trans-retinal6FUF-Rhodopsin-All-trans-retinal-Go/&β;1/&γ;2
25.00Single6GDGNECA6GDG-A2A-NECA-Gs/&β;1/&γ;1
25.00Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
25.00Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
25.00Single6LPLZM2413856LPL-A2A-ZM241385-Na
25.00Single6ME5Agomelatine6ME5-MT1-Agomelatine
25.00Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
25.00Single6ME9Ramelteon6ME9-MT2-Ramelteon
25.00Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
25.00Single6PS3(S)-Carvedilol6PS3-β2-(S)-Carvedilol
25.00Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
25.00Single6S0QZM2413856S0Q-A2A-ZM241385
25.00Single6TP6Filorexant6TP6-OX1-Filorexant
25.00Single6WQAZM2413856WQA-A2A-ZM241385-Na
25.00Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
25.00Single6Z4SSR486926Z4S-NTS1-SR48692
25.00Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
25.00Single7BVQ(S)-Carazolol7BVQ-β1-(S)-Carazolol
25.00Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
25.00Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/&β;1/&γ;2
25.00Single7F8XNN90567F8X-CCKA-NN9056
25.00Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/&β;1/&γ;1
25.00Single7MT8All-trans-retinal7MT8-Rhodopsin-All-trans-retinal-GRK1
25.00Single7QA8Peptide7QA8-STE2-Peptide
25.00Single7QA8Peptide7QA8-STE2-Peptide
25.00Single7RM5ZM2413857RM5-A2A-ZM241385-Na
25.00Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
25.00Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2
25.00Single7SINNPS-21437SIN-CaS-NPS-2143
25.00Single7SINNPS-21437SIN-CaS-NPS-2143
25.00Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
25.00Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single7WC5Psilocin7WC5-5-HT2A-Psilocin
25.00Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
25.00Single8F76-8F76-OR51E2-Gs/&β;1/&γ;2
25.00Single8FN1Neurotensin/neuromedin N8FN1-NTS1-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
25.00Single8FYNZM2413858FYN-A2A-ZM241385-Na
25.00Single8GGREpinephrine8GGR-β2-Epinephrine
25.00Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
25.00Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/&β;1/&γ;2
25.00Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
25.00Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
25.00Single8POKHistamine8POK-H2-Histamine-Gs/&β;1/&γ;2
25.00Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
25.00Consensusa2a_onOrthosteric Ligand6GDG-A2A-NECA-Gs/&β;1/&γ;1
25.00Consensusalpha2a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
25.00Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
25.00Consensusamine_offOrthosteric Ligandadrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
25.00Consensusbb1_onOrthosteric Ligand8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Consensusbeta2_offOrthosteric Ligand6PS2-β2-(S)-Alprenolol 6PS3-β2-(S)-Carvedilol 6PS5-β2-(S)-Propranolol 6PS6-β2-Timolol 2RH1-β2-(S)-Carazolol 6PS4-β2-ICI 118-551 3NY9-β2-PubChem 913103
25.00Consensusbeta2_onOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
25.00Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
25.00Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
25.00Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
25.00Consensusclass-d_offOrthosteric Ligandste2_off
25.00Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
25.00Consensusgi_adrenergicOrthosteric Ligand7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
25.00Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
25.00Consensusgo_amineOrthosteric Ligandgo_adrenergic go_muscarinic go_5ht
25.00Consensusgs_adrenergicOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJI-β3-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
25.00Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Consensusnmur1_onOrthosteric Ligand7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
25.00Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
24.24Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
24.14Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
24.14Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
24.14Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
24.00Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
24.00Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
24.00Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
24.00Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
24.00Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
24.00Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
24.00Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
24.00Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
24.00Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
24.00Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
24.00Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
24.00Consensusalpha1_offOrthosteric Ligandalpha1a_off alpha1b_off
24.00Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
23.81Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
23.81Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
23.81Single4BV0Neurotensin4BV0-NTS1-Neurotensin
23.81Single4DJHJDTic4DJH-κ-JDTic
23.81Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
23.81Single5D5A(S)-Carazolol5D5A-β2-(S)-Carazolol
23.81Single5D5B(S)-Carazolol5D5B-β2-(S)-Carazolol
23.81Single5V54Methiothepin5V54-5-HT1B-Methiothepin
23.81Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
23.81Single6TQ7SB-3348676TQ7-OX1-SB-334867
23.81Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
23.81Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
23.81Single6WGTLSD6WGT-5-HT2A-LSD
23.81Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2
23.81Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1
23.81Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/&β;1/&γ;1
23.81Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
23.81Single7PX4PSB-21137PX4-A2A-PSB-2113
23.81Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
23.81Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
23.81Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2
23.81Single7W6PW967W6P-α2a-W96-Go/&β;1/&γ;2
23.81Single7W7EW587W7E-α2a-W58-Go/&β;1/&γ;2
23.81Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
23.81Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.81Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2
23.81Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
23.81Single8EFLSR170188EFL-μ-SR17018-Gi1/&β;1/&γ;2
23.81Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2
23.81Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/&β;1/&γ;2
23.81Single8JD0J9R8JD0-mGlu2; mGlu3-Glutamate-J9R
23.81Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
23.81Single8JXWVUF68848JXW-H4-VUF6884-Gi1/&β;1/&γ;2
23.81Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/&β;1/&γ;2
23.81Consensus5ht1_offOrthosteric Ligand5ht1b_off
23.81Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
23.81Consensus5ht_offOrthosteric Ligand5ht2_off 5ht5_off 5ht1_off
23.81Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCZ-β1-Iodocyanopindolol
23.81Consensuscck_onOrthosteric Ligandccka_on cckb_on
23.81Consensuschemerin_onOrthosteric Ligandcml1_on
23.81Consensuscml1_onOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
23.81Consensusdopamine_offOrthosteric Ligandd3_off d2_off d4_off
23.81Consensusgi_amineOrthosteric Ligandgi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
23.81Consensusgo_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
23.81Consensush1_offOrthosteric Ligand3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole 8X63-H1-Mepyramine 8X64-H1-Desloratadine
23.81Consensushistamine_offOrthosteric Ligandh1_off
23.81Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
23.81Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
23.81Consensusnpy_offOrthosteric Ligandnpy2_off npy1_off
23.68Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
23.53Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
23.53Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
23.53Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
23.53Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
23.53Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
23.53Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2
23.53Single7SRQLSD7SRQ-5-HT2B-LSD
23.53Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
23.53Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/&β;1/&γ;2
23.53Single8GEIEpinephrine8GEI-β2-Epinephrine-Gs/&β;1/&γ;2
23.53Single8GGCEpinephrine8GGC-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
23.53Single8GGEEpinephrine8GGE-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
23.53Single8GGSEpinephrine8GGS-β2-Epinephrine
23.53Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
23.53Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
23.53Single8UNVEpinephrine8UNV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
23.53Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
23.53Consensus5ht4_onOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
23.53Consensusclass-t_onOrthosteric Ligandtaste2_on
23.53Consensusgs_class-tOrthosteric Ligandgs_taste
23.53Consensusgs_tasteOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
23.53Consensusmt1_onOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
23.53Consensusmt2_onOrthosteric Ligand7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
23.53Consensustaste2_onOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
23.08Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
23.08Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
23.08Consensusgi_chemerinOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
23.08Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.08Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.08Consensusmc5_onOrthosteric Ligand8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
23.08Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
22.73Single3D4STimolol Maleate3D4S-β2-Timolol Maleate
22.73Single4AMIBucindolol4AMI-β1-Bucindolol
22.73Single4GRVNeurotensin 8-134GRV-NTS1-Neurotensin 8-13
22.73Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
22.73Single4XEENeurotensin4XEE-NTS1-Neurotensin
22.73Single4XESNeurotensin4XES-NTS1-Neurotensin
22.73Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
22.73Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
22.73Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
22.73Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
22.73Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/&β;1/&γ;2
22.73Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
22.73Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
22.73Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/&β;1/&γ;2
22.73Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
22.73Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
22.73Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
22.73Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
22.73Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.73Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.73Single8IBUErythromycin A8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.73Single8J6DEP1418J6D-C3aB-EP141-Go/&β;1/&γ;2
22.73Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.73Single8JWYPubChem 1684517108JWY-A2A-PubChem 168451710
22.73Consensusat2_offOrthosteric Ligand7JNI-AT2-Olodanrigan
22.73Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
22.73Consensusdp_offOrthosteric Liganddp2_off
22.73Consensusnts1_onOrthosteric Ligand6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
22.73Consensusnts_onOrthosteric Ligandnts1_on
22.73Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
22.22Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
22.22Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
22.22Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
22.22Single3VG9ZM2413853VG9-A2A-ZM241385-Antibody
22.22Single4S0VSuvorexant4S0V-OX2-Suvorexant
22.22Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
22.22Single5ZKQABT-4915ZKQ-PAF-ABT-491
22.22Single6JODAngiotensin II6JOD-AT2-Angiotensin II
22.22Single6KUXRS-799486KUX-α2a-RS-79948
22.22Single6ME2Ramelteon6ME2-MT1-Ramelteon
22.22Single6OBA(S)-Alprenolol6OBA-β2-(S)-Alprenolol-GTPL11074
22.22Single6OYAAll-trans-retinal6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
22.22Single6TPJSuvorexant6TPJ-OX2-Suvorexant
22.22Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
22.22Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
22.22Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2
22.22Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;1
22.22Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
22.22Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
22.22Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
22.22Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.22Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
22.22Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
22.22Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.22Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
22.22Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
22.22Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
22.22Single7W0OElabela7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
22.22Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
22.22Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
22.22Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2
22.22Single8DWHCompound-168DWH-MRGPRX1-Compound-16-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.22Single8GECEpinephrine8GEC-β2-Epinephrine-Gs/&β;1/&γ;2
22.22Single8GEDEpinephrine8GED-β2-Epinephrine-Gs/&β;1/&γ;2
22.22Single8GEFEpinephrine8GEF-β2-Epinephrine-Gs/&β;1/&γ;2
22.22Single8GG7Epinephrine8GG7-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.22Single8GG9Epinephrine8GG9-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.22Single8GGAEpinephrine8GGA-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.22Single8GGVEpinephrine8GGV-β2-Epinephrine
22.22Single8GGWEpinephrine8GGW-β2-Epinephrine
22.22Single8GGXEpinephrine8GGX-β2-Epinephrine
22.22Single8GH0Epinephrine8GH0-β2-Epinephrine
22.22Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/&β;1/&γ;2
22.22Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
22.22Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
22.22Single8UNLEpinephrine8UNL-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.22Single8UNOEpinephrine8UNO-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.22Single8UNTEpinephrine8UNT-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.22Single8UNUEpinephrine8UNU-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.22Single8UNWEpinephrine8UNW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.22Single8UO1Epinephrine8UO1-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
22.22Consensus5ht2c_onOrthosteric Ligand8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.22Consensusalpha1_onOrthosteric Ligandalpha1a_on
22.22Consensusalpha1a_onOrthosteric Ligand7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.22Consensusalpha2_offOrthosteric Ligandalpha2a_off alpha2c_off
22.22Consensusalpha2a_offOrthosteric Ligand6KUX-α2a-RS-79948
22.22Consensusbeta2_off_alloOrthosteric Ligand6OBA-β2-(S)-Alprenolol-GTPL11074
22.22Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
22.22Consensusgt_class-aOrthosteric Ligandgt_opsin
22.22Consensusgt_opsinOrthosteric Ligandgt_sensory
22.22Consensusgt_sensoryOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
22.22Consensusmglu_onOther Ligandmglu2_on mglu4_on
21.74Single4BUONeurotensin4BUO-NTS1-Neurotensin
21.74Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
21.74Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
21.74Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
21.74Single6H7LDobutamine6H7L-β1-Dobutamine
21.74Single6IBLArformoterol6IBL-β1-Arformoterol
21.74Single6K1QIRL25006K1Q-ETB-IRL2500
21.74Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
21.74Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
21.74Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
21.74Consensusc5a1_off_ortoalloOrthosteric Ligand6C1Q-C5a1-PMX53-NDT9513727 6C1R-C5a1-PMX53-Avacopan; Na
21.74Consensuscckb_onOrthosteric Ligand7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
21.74Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.74Consensusot_onOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
21.43Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
21.43Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
21.43Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
21.43Single8WCBCyclohexylammonium ion8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.05Single2YDOAdenosine2YDO-A2A-Adenosine
21.05Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
21.05Single3REYPubChem 56973REY-A2A-PubChem 5697
21.05Single3RZECidoxepin3RZE-H1-Cidoxepin
21.05Single5K2BZM2413855K2B-A2A-ZM241385-Na
21.05Single6A94Zotepine6A94-5-HT2A-Zotepine
21.05Single6DS0Ly2660976DS0-5-HT2B-Ly266097
21.05Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
21.05Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
21.05Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
21.05Single6TP3Nemorexant6TP3-OX1-Nemorexant
21.05Single6V9SGTPL114036V9S-OX1-GTPL11403
21.05Single6VI4JDTic6VI4-κ-JDTic
21.05Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
21.05Single6ZINSR486926ZIN-NTS1-SR48692
21.05Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
21.05Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
21.05Single7T32ZM2413857T32-A2A-ZM241385
21.05Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
21.05Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
21.05Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
21.05Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
21.05Single7XOVSR1461317XOV-CCKA-SR146131-Gs/&β;1/&γ;2
21.05Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
21.05Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
21.05Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.05Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.05Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
21.05Single8GE1Epinephrine8GE1-β2-Epinephrine-Gs/&β;1/&γ;2
21.05Single8GE4Epinephrine8GE4-β2-Epinephrine-Gs/&β;1/&γ;2
21.05Single8GE6Epinephrine8GE6-β2-Epinephrine-Gs/&β;1/&γ;2
21.05Single8GE7Epinephrine8GE7-β2-Epinephrine-Gs/&β;1/&γ;2
21.05Single8GE8Epinephrine8GE8-β2-Epinephrine-Gs/&β;1/&γ;2
21.05Single8GE9Epinephrine8GE9-β2-Epinephrine-Gs/&β;1/&γ;2
21.05Single8GFVEpinephrine8GFV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.05Single8GG3Epinephrine8GG3-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.05Single8GG4Epinephrine8GG4-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.05Single8GG5Epinephrine8GG5-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.05Single8GG8Epinephrine8GG8-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.05Single8GGIEpinephrine8GGI-β2-Epinephrine
21.05Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.05Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
21.05Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2
21.05Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.05Single8UHBRO52563908UHB-TA1-RO5256390-Gs/&β;1/&γ;2
21.05Single8UNQEpinephrine8UNQ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.05Single8UNREpinephrine8UNR-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.05Single8UNSEpinephrine8UNS-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.05Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/&β;1/&γ;2
21.05Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
21.05Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.05Consensusalpha2b_onOrthosteric Ligand6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
21.05Consensuscxcr_onOrthosteric Ligandcxcr1_on cxcr2_on
21.05Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
21.05Consensush3_on_alloOrthosteric Ligand7F61-H3-PF-03654746-Cholesterol
21.05Consensuslh_on_alloOther Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
21.05Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
21.05Consensussensory_offOrthosteric Ligandopsin_off
20.83Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
20.83Single6KNMJN241-96KNM-Apelin-JN241-9
20.83Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
20.83Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
20.83Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.83Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
20.83Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
20.83Single8INRAlpha-MSH8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
20.83Single8X5YAstemizole8X5Y-H1-Astemizole
20.83Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
20.83Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
20.83Consensusgs_bombesinOrthosteric Ligand8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.83Consensusmotilin_onOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.69Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
20.69Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
20.69Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
20.69Single7SK3CXCL127SK3-ACKR3-CXCL12
20.69Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
20.69Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
20.69Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
20.69Consensusclass-d_onOrthosteric Ligandste2_on
20.00Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
20.00Single2Y01Dobutamine2Y01-β1-Dobutamine
20.00Single3NYA(S)-Alprenolol3NYA-β2-(S)-Alprenolol
20.00Single3PXOAll-trans-retinal3PXO-Rhodopsin-All-trans-retinal
20.00Single4AMJ(S)-Carvedilol4AMJ-β1-(S)-Carvedilol
20.00Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
20.00Single4QIMPubChem 249053754QIM-SMO-PubChem 24905375
20.00Single4QKXPubChem 762106284QKX-β2-PubChem 76210628
20.00Single4XT1Fractalkine4XT1-US28-Fractalkine
20.00Single5DHGPubChem 250014125DHG-NOP-PubChem 25001412
20.00Single5DYSAll-trans-retinal5DYS-Rhodopsin-All-trans-retinal
20.00Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
20.00Single5TGZAM65385TGZ-CB1-AM6538
20.00Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
20.00Single6DRXLisuride6DRX-5-HT2B-Lisuride
20.00Single6H7MSalbutamol6H7M-β1-Salbutamol
20.00Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
20.00Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
20.00Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
20.00Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
20.00Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
20.00Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
20.00Single7T2GMitragynine pseudoindoxyl7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
20.00Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
20.00Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/&β;1/&γ;2
20.00Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
20.00Single7WC4Serotonin7WC4-5-HT2A-Serotonin
20.00Single7WC7Lisuride7WC7-5-HT2A-Lisuride
20.00Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
20.00Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
20.00Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
20.00Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
20.00Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
20.00Single8EFQDamgo8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
20.00Single8J18(3R)-3-hydroxydodecanoic acid8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
20.00Single8JJOAlprenolol8JJO-β2-Alprenolol
20.00Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
20.00Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/&β;1/&γ;2
20.00Single8PWNTheophylline8PWN-A2A-Theophylline
20.00Single8UO4Epinephrine8UO4-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
20.00Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
20.00Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single8X63Mepyramine8X63-H1-Mepyramine
20.00Consensus5ht1a_onOrthosteric Ligand8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
20.00Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
20.00Consensusamine_onOrthosteric Ligandadrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on
20.00Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
20.00Consensusfsh_on_alloOther Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
20.00Consensusgabab_offOther Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
20.00Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
20.00Consensusgi_class-dOrthosteric Ligandgi_ste
20.00Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
20.00Consensusgi_hcaOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
20.00Consensusgi_hcarOrthosteric Ligandgi_hca
20.00Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
20.00Consensushca2_onOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
20.00Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
19.35Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
19.35Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
19.23Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
19.23Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
19.23Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
19.23Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
19.05Single2Y00Dobutamine2Y00-β1-Dobutamine
19.05Single5WIUNemonapride5WIU-D4-Nemonapride
19.05Single5WIVNemonapride5WIV-D4-Nemonapride-Na
19.05Single5ZK3Quinuclidinyl benzilate hydrobromide5ZK3-M2-Quinuclidinyl benzilate hydrobromide
19.05Single6D26Fevipiprant6D26-DP2-Fevipiprant
19.05Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
19.05Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
19.05Single6PS6Timolol6PS6-β2-Timolol
19.05Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
19.05Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
19.05Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
19.05Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
19.05Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
19.05Single8J19PubChem 1270454228J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
19.05Single8JPCNeurotensin 8-138JPC-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
19.05Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
19.05Consensusd4_offOrthosteric Ligand5WIU-D4-Nemonapride
19.05Consensusd4_off_alloOrthosteric Ligand5WIV-D4-Nemonapride-Na
19.05Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
18.92Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
18.75Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
18.75Single6OY9All-trans-retinal6OY9-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
18.75Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
18.75Single6TQ9SB-4081246TQ9-OX1-SB-408124
18.75Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
18.75Single7MTBAll-trans-retinal7MTB-Rhodopsin-All-trans-retinal-GRK1
18.75Single7VDMSubstance P7VDM-MRGPRX2-Substance P-Gi1/&β;1/&γ;2
18.75Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.75Single8IWM2-Phenylethylamine8IWM-TAAR9-2-Phenylethylamine
18.75Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
18.75Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
18.75Consensussensory_onOrthosteric Ligandopsin_on
18.52Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.52Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
18.52Single7XNACYN1548067XNA-SST2-CYN154806
18.52Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
18.52Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
18.52Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
18.18Single3UONQuinuclidinyl benzilate hydrobromide3UON-M2-Quinuclidinyl benzilate hydrobromide
18.18Single4U15Tiotropium4U15-M3-Tiotropium
18.18Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
18.18Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
18.18Single6OL9Tiotropium6OL9-M5-Tiotropium
18.18Single6OS1TRV0266OS1-AT1-TRV026
18.18Single7B6WCyclazosin7B6W-α1b-Cyclazosin
18.18Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2
18.18Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
18.18Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
18.18Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
18.18Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.18Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.18Single7XOWGastrin7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
18.18Single7XOXCholecystokinin-87XOX-CCKB-Cholecystokinin-8-Gq/&β;1/&γ;2
18.18Single8G056-OAU8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
18.18Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
18.18Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
18.18Consensusalpha1b_offOrthosteric Ligand7B6W-α1b-Cyclazosin
18.18Consensusangiotensin_offOrthosteric Ligandat1_off at2_off
18.18Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
18.18Consensusgi_muscarinicOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
18.18Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl Scopolamine 5ZHP-M3-PubChem 134828589
18.18Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
18.18Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
18.18Consensusrelaxin_onOrthosteric Ligandrxfp4_on
18.18Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
17.86Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
17.86Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
17.86Consensusclass-d_onOrthosteric Ligandste2_on
17.86Consensusgi_class-dOrthosteric Ligandgi_ste
17.86Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
17.86Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
17.65Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
17.65Single3OE6IT1t3OE6-CXCR4-IT1t
17.65Single3PQRAll-trans-retinal3PQR-Rhodopsin-All-trans-retinal-Gt(CT)
17.65Single3UZAGTPL92363UZA-A2A-GTPL9236
17.65Single4XNWMRS25004XNW-P2Y1-MRS2500
17.65Single7MT9All-trans-retinal7MT9-Rhodopsin-All-trans-retinal-GRK1
17.65Single7MTAAll-trans-retinal7MTA-Rhodopsin-All-trans-retinal-GRK1
17.65Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.65Single8GGZEpinephrine8GGZ-β2-Epinephrine
17.65Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/&β;1/&γ;2
17.65Single8IW72-Phenylethylamine8IW7-TAAR9-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
17.65Single8J6QBeta-hydroxybutyrate8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
17.65Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/&β;1/&γ;2
17.65Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
17.65Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.65Consensusopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
17.65Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
17.39Single5CXVTiotropium5CXV-M1-Tiotropium
17.39Single6A93Risperidone6A93-5-HT2A-Risperidone
17.39Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
17.39Single6CM4Risperidone6CM4-D2-Risperidone
17.39Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
17.39Single6H7N(S)-Xamoterol6H7N-β1-(S)-Xamoterol
17.39Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
17.39Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
17.39Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
17.39Single6YVRNTS8-136YVR-NTS1-NTS8-13
17.39Single6ZG4HTL00099366ZG4-M1-HTL0009936
17.39Single7DFPSpiperone7DFP-D2-Spiperone
17.39Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
17.39Single7WCNAR2314537WCN-GPR119-AR231453-Gs/&β;1/&γ;2
17.39Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.39Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.39Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.39Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2
17.39Single8JWZAB9288JWZ-A2A-AB928-Na
17.39Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg3_on
17.39Consensusbeta1_onOrthosteric Ligand7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
17.39Consensusclass-b2_onOrthosteric Ligandadgrg_on
17.39Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
17.39Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
17.39Consensusgi_class-fOther Ligandgi_frizzled
17.39Consensusgi_frizzledOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
17.39Consensusgpr119_onOrthosteric Ligand7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
17.39Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
17.39Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
17.24Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
17.24Consensusbk1_onOrthosteric Ligand7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.24Consensusbombesin_onOrthosteric Ligandbb2_on bb1_on
17.24Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
16.67Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
16.67Single2G87All-trans-retinal2G87-Rhodopsin-All-trans-retinal
16.67Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
16.67Single3OE9IT1t3OE9-CXCR4-IT1t
16.67Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
16.67Single4XT3Fractalkine4XT3-US28-Fractalkine
16.67Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
16.67Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
16.67Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
16.67Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
16.67Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
16.67Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
16.67Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
16.67Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
16.67Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
16.67Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
16.67Single7UL2SR486927UL2-NTS1-SR48692-Na
16.67Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
16.67Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
16.67Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
16.67Single7XZ6APD6687XZ6-GPR119-APD668-Gs/&β;1/&γ;2
16.67Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
16.67Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67Single8GGYEpinephrine8GGY-β2-Epinephrine
16.67Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/&β;1/&γ;2
16.67Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2
16.67Single8ITFDMCHA8ITF-TAAR9-DMCHA-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single8UNXEpinephrine8UNX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
16.67Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
16.67Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single8X2K5YM8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
16.67Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
16.67Consensusgs_galaninOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67Consensusgs_lipidOrthosteric Ligandgs_ffa gs_prostanoid
16.67Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
16.67Consensusnts1_off_alloOrthosteric Ligand7UL2-NTS1-SR48692-Na
16.67Consensuspth_onOrthosteric Ligandpth1_on pth2_on
16.22Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
16.13Consensusgo_class-b1Orthosteric Ligandgo_crf
16.13Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
16.13Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
16.00Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
16.00Single7SK9CCX6627SK9-ACKR3-CCX662
16.00Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
16.00Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
15.79Single3ODUIT1t3ODU-CXCR4-IT1t
15.79Single5DHHSB-6121115DHH-NOP-SB-612111
15.79Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
15.79Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
15.79Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
15.79Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2
15.79Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
15.79Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
15.79Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
15.79Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
15.79Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
15.79Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2
15.79Single8A6CAll-trans-retinal8A6C-Rhodopsin-All-trans-retinal
15.79Single8A6DAll-trans-retinal8A6D-Rhodopsin-All-trans-retinal
15.79Single8A6EAll-trans-retinal8A6E-Rhodopsin-All-trans-retinal
15.79Single8FN0Neurotensin/neuromedin N8FN0-NTS1-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
15.79Single8GEAEpinephrine8GEA-β2-Epinephrine-Gs/&β;1/&γ;2
15.79Single8HOCImetit8HOC-H4-Imetit-Gi1/&β;1/&γ;2
15.79Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2
15.79Single8IW4Spermidine8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2
15.79Single8IWESpermidine8IWE-TAAR9-Spermidine
15.79Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
15.79Single8U8FPML8U8F-GPR3-PML-Gs/&β;1/&γ;2
15.79Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
15.79Consensus5ht2_onOrthosteric Ligand5ht2a_on 5ht2c_on
15.79Consensusclass-f_offOrthosteric Ligandsmo_off
15.79Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
15.79Consensusgi_histamineOrthosteric Ligand8HN8-H4-Histamine-Gi1/&β;1/&γ;2 8HOC-H4-Imetit-Gi1/&β;1/&γ;2
15.79Consensusgs_histamineOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.79Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
15.79Consensush4_onOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.79Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
15.79Consensusm2_on_alloOther Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
15.79Consensusopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
15.62Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
15.62Consensuscrf1_onOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
15.38Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
15.38Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
15.38Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
15.38Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
15.15Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
15.15Consensusgs_crfOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
15.00Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
15.00Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
15.00Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
15.00Single6ZDVPubChem 9840736ZDV-A2A-PubChem 984073-Na
15.00Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2
15.00Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
15.00Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.00Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
15.00Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2
15.00Single7XJJGalanin7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
15.00Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
15.00Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
15.00Single8JERAcipimox8JER-HCA2-Acipimox-Go/&β;1/&γ;2
15.00Single8JIMMMF8JIM-HCA2-MMF-Gi1/&β;1/&γ;2
15.00Single8JLNT1AM8JLN-TA1-T1AM-Gs/&β;1/&γ;2
15.00Single8K5CAcipimox8K5C-HCA2-Acipimox
15.00Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6WH4-5-HT2A-Methiothepin 7VOE-5-HT2A-Aripiprazole 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 6A93-5-HT2A-Risperidone
15.00Consensus5ht2a_onOrthosteric Ligand7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.00Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
15.00Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
15.00Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
15.00Consensusgo_galaninOrthosteric Ligand7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
15.00Consensushca_onOrthosteric Ligandhca2_on hca3_on
15.00Consensushcar_onOrthosteric Ligandhca_on
15.00Consensusm1_off_alloOrthosteric Ligand6WJC-M1-Atropine-Muscarinic toxin 7
15.00Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
15.00Consensuss1p_offOrthosteric Ligands1p1_off
14.81Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
14.81Consensussst_offOrthosteric Ligandsst2_off
14.71Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
14.71Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
14.29Single4DAJTiotropium4DAJ-M3-Tiotropium
14.29Single4MQSIperoxo4MQS-M2-Iperoxo
14.29Single4U14Tiotropium4U14-M3-Tiotropium
14.29Single4U16N-Methyl Scopolamine4U16-M3-N-Methyl Scopolamine
14.29Single4YAYZD-71554YAY-AT1-ZD-7155
14.29Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
14.29Single5T04Neurotensin5T04-NTS1-Neurotensin
14.29Single5YC8N-Methyl Scopolamine5YC8-M2-N-Methyl Scopolamine
14.29Single5ZK8N-Methyl Scopolamine5ZK8-M2-N-Methyl Scopolamine
14.29Single5ZKCN-Methyl Scopolamine5ZKC-M2-N-Methyl Scopolamine
14.29Single6D27CAY104716D27-DP2-CAY10471
14.29Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
14.29Single6GPSMK08126GPS-CCR2-MK0812
14.29Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
14.29Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.29Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
14.29Single7F83PF-051904577F83-Ghrelin-PF-05190457
14.29Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
14.29Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
14.29Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
14.29Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/&β;1/&γ;2
14.29Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
14.29Consensusgo_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
14.29Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
14.29Consensushca3_onOrthosteric Ligand8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
14.29Consensushistamine_onOrthosteric Ligandh1_on h4_on
14.29Consensusm2_on_alloOrthosteric Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
14.29Consensusm4_on_alloOrthosteric Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
14.29Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
13.89Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
13.89Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
13.89Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
13.79Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
13.79Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
13.79Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
13.79Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
13.64Single6GPXMK08126GPX-CCR2-MK0812
13.64Single6LUQHaloperidol6LUQ-D2-Haloperidol
13.64Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
13.64Single7C4SS1P7C4S-S1P3-S1P
13.64Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
13.64Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
13.64Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2
13.64Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
13.64Single7YXAONO-54306087YXA-S1P5-ONO-5430608
13.64Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.64Single8EA0Iperoxo8EA0-M3-Iperoxo
13.64Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2
13.64Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
13.64Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide 6DRX-5-HT2B-Lisuride
13.64Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
13.64Consensusgs_muscarinicOrthosteric Ligand8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.64Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
13.64Consensusm2_offOrthosteric Ligand5ZKB-M2-AF-DX 384 5ZKC-M2-N-Methyl Scopolamine 5ZK3-M2-Quinuclidinyl benzilate hydrobromide
13.64Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.51Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
13.33Single4A4MAll-trans-retinal4A4M-Rhodopsin-All-trans-retinal-Gt(CT)
13.33Single5EN0All-trans-retinal5EN0-Rhodopsin-All-trans-retinal-Gt(CT)
13.33Single5MZPCaffeine5MZP-A2A-Caffeine-Na
13.33Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
13.33Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
13.33Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
13.04Single5V56TC1145V56-SMO-TC114
13.04Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
13.04Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
13.04Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
13.04Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2
13.04Single7EPENAM5637EPE-mGlu-NAM563
13.04Single7F1TMIP-1a7F1T-CCR5-MIP-1a
13.04Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
13.04Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2
13.04Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2
13.04Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/&β;1/&γ;2
13.04Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
13.04Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
13.04Consensusmglu2_onOther Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
13.04Consensuss1p2_onOrthosteric Ligand7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
12.90Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
12.90Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
12.90Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
12.90Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
12.90Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
12.50Single4N4WSANT-14N4W-SMO-SANT-1
12.50Single6OS2TRV0266OS2-AT1-TRV026
12.50Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
12.50Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
12.50Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
12.50Single7K15MKD0467K15-BLT1-MKD046-Na
12.50Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
12.50Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
12.50Single8GEJEpinephrine8GEJ-β2-Epinephrine-Gs/&β;1/&γ;2
12.50Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
12.50Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
12.50Consensusblt1_offOrthosteric Ligand7K15-BLT1-MKD046-Na
12.50Consensusblt_offOrthosteric Ligandblt1_off
12.50Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
12.50Consensuschemokine_offOrthosteric Ligandcxcr_off
12.50Consensusclass-c_onOther Ligandgabab_on mglu_on
12.50Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II
12.50Consensuscxcr_offOrthosteric Ligandcxcr4_off
12.12Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
12.12Single6LMLGlucagon6LML-Glucagon-Glucagon
12.12Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
12.12Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
12.12Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
12.12Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
12.12Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
12.12Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
12.12Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
12.12Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
12.12Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
12.00Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
12.00Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
12.00Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
12.00Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
12.00Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.00Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.00Consensusadgrg2_onOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
12.00Consensusfpa_onOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.76Single2HPYAll-trans-retinal2HPY-Rhodopsin-All-trans-retinal
11.76Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
11.76Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
11.76Single8WC5Tetramethylammonium ion8WC5-TA1-Tetramethylammonium ion-chim(NtGi1-Gs)/&β;1/&γ;2
11.76Consensushca2_on_alloOrthosteric Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
11.54Single5EE7MK08935EE7-Glucagon-MK0893
11.54Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.54Consensusgs_adgrOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
11.54Consensusgs_class-b2Orthosteric Ligandgs_adgr
11.43Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
11.43Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
11.43Consensusglp_onOrthosteric Ligandglp1_on glp2_on
11.11Single3OE8IT1t3OE8-CXCR4-IT1t
11.11Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
11.11Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
11.11Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
11.11Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
11.11Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
11.11Consensussmo_off_alloOrthosteric Ligand6D32-SMO-Cyclopamine-Cyclopamine
10.81Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
10.71Single7SK5CXCL127SK5-ACKR3-CXCL12
10.53Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
10.53Single4O9RCyclopamine4O9R-SMO-Cyclopamine
10.53Single5L7IVismodegib5L7I-SMO-Vismodegib
10.53Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
10.53Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
10.53Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.53Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2
10.53Single8HN8Histamine8HN8-H4-Histamine-Gi1/&β;1/&γ;2
10.53Single8IJANiacin8IJA-HCA2-Niacin-Gi1/&β;1/&γ;2
10.53Single8IY9Niacin8IY9-HCA2-Niacin-Go/&β;1/&γ;2
10.53Single8JILNiacin8JIL-HCA2-Niacin-Gi1/&β;1/&γ;2
10.53Single8K5BNiacin8K5B-HCA2-Niacin
10.53Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
10.53Consensusgo_adhesionOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
10.53Consensusgo_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
10.53Consensusgo_class-b2Orthosteric Ligandgo_adhesion
10.53Consensusgo_proteinOrthosteric Ligandgo_chemokine
10.34Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
10.00Single4BWBNeurotensin4BWB-NTS1-Neurotensin
10.00Single4QINSAG1.54QIN-SMO-SAG1.5
10.00Single5U09Taranabant5U09-CB1-Taranabant
10.00Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
10.00Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
10.00Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
10.00Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
10.00Single6WWZCCL206WWZ-CCR6-CCL20-Go/&β;1/&γ;2
10.00Single8IHKAcifran8IHK-HCA3-Acifran
10.00Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/&β;1/&γ;2
10.00Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
10.00Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
10.00Consensussmo_on_alloOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
9.76Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
9.76Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
9.68Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
9.68Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
9.68Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
9.68Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
9.52Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
9.52Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
9.52Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
9.52Single6ZG9GSK10347026ZG9-M1-GSK1034702
9.52Single7BB6Acyclovir triphosphate7BB6-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
9.52Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
9.52Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
9.52Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
9.52Single7VODCariprazine7VOD-5-HT2A-Cariprazine
9.52Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
9.52Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
9.52Single8GCML9026888GCM-EP4-L902688-Gi1/&β;1/&γ;2
9.52Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2
9.52Single8IYXYL-3658IYX-GPR34-YL-365
9.52Single8JHNMMF8JHN-HCA2-MMF-Go/&β;1/&γ;2
9.52Single8K2WAMG4878K2W-CXCR3-AMG487
9.52Consensusgi_class-fOrthosteric Ligandgi_frizzled
9.52Consensusgi_frizzledOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
9.52Consensusm1_off_alloOther Ligand6WJC-M1-Atropine-Muscarinic toxin 7
9.38Single6FJ3PTH6FJ3-PTH1-PTH
9.38Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
9.38Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/&β;1/&γ;2
9.38Single7D3SSecretin7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
9.38Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
9.38Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
9.38Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
9.38Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
9.38Consensusghrh_onOrthosteric Ligand7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
9.30Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
9.09Single5DSGTiotropium5DSG-M4-Tiotropium
9.09Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
9.09Single6IIVDaltroban6IIV-TP-Daltroban
9.09Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
9.09Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
9.09Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
9.09Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
9.09Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
9.09Single7VKTLTB47VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
9.09Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
9.09Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
9.09Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
9.09Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/&β;1/&γ;2
9.09Single8K5DGSK2560738K5D-HCA2-GSK256073
9.09Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-alpha-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
9.09Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
9.09Consensusblt_onOrthosteric Ligandblt1_on
9.09Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
9.09Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
9.09Consensushcar_offOrthosteric Ligandsuccinate_off
9.09Consensusleuko_onOrthosteric Ligandblt_on
9.09Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
9.09Consensusprostanoid_offOrthosteric Ligandep_off tp_off dp_off
9.09Consensussmo_offOrthosteric Ligand5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
9.09Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
9.09Consensustp_offOrthosteric Ligand6IIV-TP-Daltroban 6IIU-TP-Ramatroban
8.82Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
8.70Single4JKVTaladegib (LY2940680)4JKV-SMO-Taladegib (LY2940680)
8.70Single5CGCHTL142425CGC-mGlu5-HTL14242
8.70Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
8.70Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
8.70Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
8.70Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
8.70Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
8.70Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2
8.70Single8GDAL9026888GDA-EP4-L902688-Gs/&β;1/&γ;2
8.70Single8GDCPGE28GDC-EP3-PGE2-Gi1/&β;1/&γ;2
8.70Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
8.70Consensusccr2_off_alloOther Ligand5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
8.70Consensusep3_onOrthosteric Ligand8GDC-EP3-PGE2-Gi1/&β;1/&γ;2
8.70Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
8.70Consensusep_offOrthosteric Ligandep4_off
8.33Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
8.33Single5V57TC1145V57-SMO-TC114
8.33Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
8.33Single8X79MRE-2698X79-I2-MRE-269-Gs/&β;1/&γ;2
8.11Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
8.11Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
8.11Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
8.00Single5X33BIIL2605X33-BLT1-BIIL260
8.00Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
8.00Single6IIURamatroban6IIU-TP-Ramatroban
8.00Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
8.00Single8GCPPGE28GCP-EP4-PGE2-Gi1/&β;1/&γ;2
8.00Consensusep_onOrthosteric Ligandep4_on ep2_on ep3_on
8.00Consensusgi_prostanoidOrthosteric Ligand8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GDC-EP3-PGE2-Gi1/&β;1/&γ;2 8GCM-EP4-L902688-Gi1/&β;1/&γ;2
8.00Consensusprostanoid_onOrthosteric Ligandep_on fpa_on
7.89Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
7.69Single5CGDHTL142425CGD-mGlu5-HTL14242
7.69Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/&β;1/&γ;2
7.69Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2
7.69Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
7.69Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.69Consensusep2_onOrthosteric Ligand7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
7.69Consensusep4_onOrthosteric Ligand7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2
7.69Consensusgs_prostanoidOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.41Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
7.41Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.32Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
7.14Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
7.14Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
6.98Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
6.90Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
6.90Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
6.90Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
6.25Single6W25Ca6W25-MC4-SHU9119-Ca
6.25Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
6.25Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
6.25Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
6.25Consensusccr8_offOrthosteric Ligand8TLM-CCR8-Anti-murine CCR8 antibody
6.25Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
6.06Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
6.06Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
6.06Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
5.88Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
5.88Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
5.88Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
5.88Single7XKEBetahydroxyandrosterone7XKE-ADGRG2-Betahydroxyandrosterone-chim(NtGi1-Gs)/&β;1/&γ;2
5.88Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/&β;1/&γ;2
5.88Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
5.71Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
5.71Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
5.71Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
5.56Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
5.56Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
5.56Single7XKDBetahydroxyandrosterone7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
5.56Single7Y14Beta-alanine7Y14-MRGPRD-Beta-alanine
5.56Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/&β;1/&γ;2
5.56Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/&β;1/&γ;2
5.56Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
5.56Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
5.26Single6LI0GTPL98046LI0-GPR52-GTPL9804
5.26Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2
5.26Single7Y12Beta-alanine7Y12-MRGPRD-Beta-alanine-Gi1/&β;1/&γ;2
5.26Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
5.26Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
5.26Single8WG8Peptide8WG8-Glucagon-Peptide-chim(NtGi1-Gs)/&β;1/&γ;2
5.26Consensusgip_on_alloOther Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
5.13Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
5.00Single3AYMAll-trans-retinal3AYM-Rhodopsin-All-trans-retinal
5.00Single7XKFBetahydroxyandrosterone7XKF-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
5.00Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
5.00Single8J6QCompound 9n8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
5.00Consensushca2_on_alloOther Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
5.00Consensusm4_on_alloOther Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
5.00Consensussmo_on_alloOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
4.76Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
4.76Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
4.76Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
4.76Single8HMPPubChem 699214798HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
4.76Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
4.76Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2
4.55Single6FFIMMPEP6FFI-mGlu5-MMPEP
4.55Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/&β;1/&γ;2
4.55Consensusgs_ctOrthosteric Ligand7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
4.35Single6FFHFenobam6FFH-mGlu5-Fenobam
4.35Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/&β;1/&γ;2
4.35Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
4.17Single4WW3All-trans-retinal4WW3-Rhodopsin-All-trans-retinal
4.00Single7P2L4YI7P2L-mGlu5-4YI
4.00Single8GDBPGE28GDB-EP4-PGE2-Gs/&β;1/&γ;2
4.00Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.00Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
4.00Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
3.85Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
3.85Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1
3.85Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
3.70Single7CX2PGE27CX2-EP2-PGE2-Gs/&β;1/&γ;2
3.45Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
3.45Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
3.33Single7SHEPI; PE7SHE-GPR158-PI; PE
3.12Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
3.12Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
3.12Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
3.03Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
2.86Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
2.78Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
2.78Consensuscalcitonin_onOrthosteric Ligandct_on ctlike_on
2.70Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
2.70Single7TYIAmylin7TYI-CT-Amylin-Gs/&β;1/&γ;2
2.70Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
2.63Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
2.56Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
2.56Single8F0KPramlintide analogue san3858F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.50Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
2.50Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
2.38Single8F2APramlintide analogue san3858F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.27Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
2.22Single8F2BPramlintide analogue san458F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
2.13Single8F0JPramlintide analogue san458F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2

Consensus Members
Id Members
8ID6 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
8G59 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
8ID3 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
8ID9 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
8ID4 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
8J22 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
8J24 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
8J21 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
Net Summary
Imin 2.8425
Number of Linked Nodes 907
Number of Links 1123
Number of Hubs 182
Number of Links mediated by Hubs 701
Number of Communities 25
Number of Nodes involved in Communities 276
Number of Links involved in Communities 409
Path Summary
Number Of Nodes in MetaPath 110
Number Of Links MetaPath 109
Number of Shortest Paths 3979813
Length Of Smallest Path 3
Average Path Length 35.4919
Length of Longest Path 59
Minimum Path Strength 0.18
Average Path Strength 5.46933
Maximum Path Strength 21.89
Minimum Path Correlation 0.7
Average Path Correlation 0.977609
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.92308
Average % Of Corr. Nodes 29.4824
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 53.676
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following consensuses:
IdComponents
gi_lipidgi_cannabinoid
gi_prostanoid
gi_ffa
gi_lpl
gi_leukotriene



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