Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
1G.HN.11 2.22422502
2G.S1.01 4.45409416
3G.S1.02 5.09273535
4G.S1.06 3.90575438
5G.H1.01 3.55484439
6G.H1.07 4.67702439
7G.S2.05 4.71083413
8G.S2.06 5.16647439
9G.S2.08 6.96972435
10G.S3.03 8.50913437
11G.S3.04 5.91073516
12G.S3.05 3.10005637
13G.S3.06 6.75754615
14G.S3.07 3.01901439
15G.s3h2.03 4.30991519
16G.H2.04 3.29825409
17G.H2.06 5.11857619
18G.H2.07 4.48667619
19G.H2.09 4.396674128
20G.S4.03 3.1331437
21G.S4.06 3.31357407
22G.s4h3.04 6.4668678
23G.s4h3.05 8.09036479
24G.H3.01 6.24968479
25G.H3.09 5.002596139
26G.H3.13 3.427655135
27G.H3.17 6.91324505
28G.H3.18 5.817784119
29G.S5.03 3.16248538
30G.S5.05 3.57257639
31G.S5.06 5.03163408
32G.S5.07 4.20567439
33G.HG.03 3.156314156
34G.HG.04 5.05273579
35G.hgh4.01 4.50321406
36G.hgh4.02 5.33347697
37G.hgh4.05 7.8821497
38G.H4.03 5.60032404
39G.H4.05 4.58575494
40G.H4.10 9.78433496
41G.H4.15 3.99821408
42G.h4s6.02 4.968174138
43G.h4s6.11 4.770244137
44G.h4s6.12 5.42988404
45G.S6.02 5.198766147
46G.H5.03 4.18908538
47G.H5.08 5.94937438
48G.H5.13 4.863785148
49G.H5.20 3.96103429
50G.H5.26 2.46127405
51b.1x1 2.09975504
52b.1x11 2.68774408
53b.lhb1x3 3.62849402
54b.b1x4 2.83524407
55b.b1x6 6.67071459
56b.l1x3 7.04862659
57b.b2x1 6.349875128
58b.b2x5 5.49899657
59b.l3x2 4.78115409
60b.b4x2 4.16389408
61b.b4x6 8.38864759
62b.b5x3 5.4624759
63b.b5x5 4.3381405
64b.b5x7 4.68306407
65b.l5x1 4.276914178
66b.l5x5 6.26526719
67b.b6x5 4.09992406
68b.b7x1 5.51314504
69b.b7x4 2.719214178
70b.l7x2 2.84567419
71b.l7x4 2.39571409
72b.b8x4 4.86905406
73b.l8x5 2.944255183
74b.l9x3 6.88876619
75b.l9x6 4.10224918
76b.b10x5 3.43812609
77b.l10x1 3.70988403
78b.b11x4 5.27595419
79b.l11x2 7.6075419
80b.b12x6 8.2546718
81b.b13x7 7.16822547
82b.l13x3 7.08415649
83b.b14x3 3.85044445
84b.b15x1 5.31577649
85b.b15x2 5.90575416
86b.l15x2 5.09325449
87b.b16x4 9.965446
88b.b16x5 4.00346505
89b.b16x6 8.32066648
90b.b17x5 5.50278417
91b.b17x7 7.10643418
92b.l17x3 7.08108619
93b.l17x6 5.49035519
94b.b18x3 3.69869418
95b.l18x1 5.472797106
96b.l18x2 6.071234107
97b.b19x2 5.0525716
98b.b19x4 4.86013518
99b.l19x2 5.6947519
100b.b20x4 7.91423618
101b.b20x6 6.41562516
102b.b20x7 3.26694409
103b.l20x2 7.48492409
104b.b21x1 5.98102517
105b.b21x2 4.0794406
106b.b21x5 4.81405464
107b.b21x7 4.92384665
108b.b22x5 5.138355107
109b.l22x5 6.87686409
110b.b23x6 6.76997667
111b.l23x1 6.46611406
112b.b24x4 7.69163466
113b.b24x6 5.77484468
114b.l24x3 4.36248505
115b.b25x3 5.27806565
116b.l25x3 7.56571589
117b.b26x3 3.47829406
118b.l27x1 9.37826129
119b.l27x2 7.4898489
120b.b28x3 4.27071457
121b.b28x4 5.28218486
122b.b28x6 7.24487689
123g.h1x1 2.58448502
124g.h1x11 2.22579409
125g.l1x2 4.0452412
126g.l1x4 5.41262418
127g.h2x11 6.809374106
128g.ctx3 6.149846209
129g.ctx6 3.44563406
130g.ctx16 4.9813508
131Lig 5.876761620
132NT 17.51026
1331x39 3.69222406
1341x50 5.45349409
1351x57 2.32544407
136I1x49 2.65905406
1372x38 3.848534227
1382x39 3.06242408
1392x40 5.32448509
1402x42 4.69689508
1412x46 3.88052429
1422x50 5.75734409
1432x57 5.31614606
1443x25 8.85254529
1453x28 5.32508626
1463x29 8.61194425
1473x32 3.23333426
1483x33 5.33635525
1493x43 3.64028429
1503x44 3.90698407
1513x49 4.4344409
1523x50 4.33844629
1533x56 3.49579406
1544x41 3.57754225
1554x50 3.555364239
156E2 14.37641924
1575x39 7.2782627
1585x58 3.65206609
1595x62 6.38187406
1606x33 3.58508428
1616x44 4.57726429
1626x48 5.68254728
1636x52 6.26579406
164E3 4.49018722
1657x31 5.01508423
1667x45 8.17024429
1677x53 4.52814429
1686x26 3.21417400
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1b.l2x5 b.l4x2 11.626122.8827NoNo054
2b.l4x2 g.ctx15 25.542210.9298NoNo049
3b.l26x5 g.ctx15 26.10364.50048NoNo059
4b.l26x5 g.ctx4 53.79144.31095NoNo057
5g.ctx3 g.ctx4 54.34934.03778YesNo097
6g.ctx3 g.ctx6 57.70357.51778YesYes096
7b.l22x5 g.ctx6 59.99823.47063YesYes096
8b.l22x5 b.lhb1x3 31.22334.67175YesYes092
9b.h2x5 b.lhb1x3 35.11963.3054NoYes052
10b.h2x1 b.h2x5 66.73653.67429NoNo055
11b.b21x5 b.h2x1 67.41125.78841YesNo045
12b.b21x5 b.b21x7 68.228.62968YesYes645
13b.b21x7 b.b24x6 80.03584.49984YesYes658
14b.b23x6 b.b24x6 79.10317.55YesYes678
15b.b23x6 b.l23x2 81.73934.58175YesNo078
16b.l21x7 b.l23x2 82.69135.92778NoNo058
17b.l21x7 b.l23x1 82.87876.24841NoYes056
18b.b22x1 b.l23x1 1002.34349NoYes086
19b.b22x1 b.b22x2 99.82463.73333NoNo088
20b.b22x2 b.b26x3 99.64863.38286NoYes086
21b.b26x3 b.b27x3 97.46022.73714YesNo068
22b.b27x3 b.l25x3 94.75118.01905NoYes089
23b.l25x3 b.l27x2 94.3764.98YesYes899
24b.l25x4 b.l27x2 94.07966.59NoYes059
25I1x49 b.l25x4 93.68142.91889YesNo065
268x49 I1x49 92.44593.15NoYes076
272x40 8x49 92.25114.20444YesNo097
282x37 2x40 88.82054.57032NoYes079
292x37 2x39 88.60762.97603NoYes078
302x39 3x49 10.83784.14587YesYes089
31b.l22x5 b.l24x2 30.86846.18889YesNo096
32b.h2x5 b.l24x2 31.40434.98429NoNo056
33G.HN.47 b.b5x3 13.48392.82NoYes069
34G.HN.47 b.b4x2 13.29944.65524NoYes068
35b.l23x1 b.l25x6 83.605912.8548YesNo068
36b.l25x6 b.l27x1 80.994315.0414NoYes089
37b.b2x1 b.l27x1 80.53665.85YesYes1289
38b.b2x1 b.l3x1 83.47449.94968YesNo089
39b.l3x1 b.l5x5 83.53657.19921NoYes099
40G.S3.06 b.l5x5 54.902511.1043YesYes159
41G.S1.03 G.S3.06 51.08596.94952NoYes195
42G.S1.03 I2x53 51.06892.52111NoNo097
43I2x52 I2x53 50.31282.31127NoNo047
44G.S1.02 I2x52 47.64794.59873YesNo054
45G.S1.02 G.S3.03 40.63827.84762YesYes357
46G.S2.06 G.S3.03 40.384613.4884YesYes397
47G.S2.06 G.S3.05 38.77252.70587YesYes397
48G.S1.04 G.S3.05 15.58382.93857NoYes077
49G.S1.04 G.S4.03 15.17123.41746NoYes077
50G.S1.06 G.S3.05 21.52444.91381YesYes387
51G.S1.06 G.S4.03 15.2332.98762YesYes387
52G.H2.04 G.H2.07 72.95584.25397YesYes099
53G.H2.07 b.l7x2 40.01942.47857YesYes199
54b.l5x5 b.l7x2 86.40753.14714YesYes199
55b.l7x2 b.l9x6 45.02522.69587YesYes198
56b.l17x5 b.l17x6 73.70463.5973NoYes169
57b.l17x5 b.l19x2 74.80192.80381NoYes169
58b.l17x3 b.l19x2 64.39552.64YesYes199
59b.b19x4 b.l17x3 54.10046.45556YesYes189
60b.b18x3 b.b19x4 15.35514.80127YesYes188
61b.b15x2 b.b18x3 15.07933.75619YesYes168
62b.b15x2 b.b18x5 23.71410.5524YesNo065
63b.b18x5 b.l14x1 21.91483.83NoNo054
64b.l14x1 b.l14x3 20.13143.1873NoNo045
65b.l14x3 b.l14x5 19.5394.70587NoNo055
66b.l14x5 b.l16x2 18.94748.89905NoNo059
67b.l16x1 b.l16x2 18.35943.90381NoNo049
68b.b15x1 b.l16x1 14.66262.49524YesNo094
69b.b14x3 b.b15x1 16.28812.82206YesYes459
70b.b10x2 b.b14x3 15.65156.09762NoYes065
71b.b10x2 b.b10x4 15.28224.1127NoNo066
72b.b10x4 b.b2x4 14.91328.2954NoNo066
73b.b2x4 b.b6x5 14.56213.70254NoYes066
74b.b3x3 b.b6x5 13.47014.16571NoYes086
75b.b3x3 b.b4x3 11.39654.18619NoNo087
76b.b4x3 b.b5x7 10.70223.21429NoYes077
77b.b5x7 b.b5x8 14.32843.39YesNo075
78b.b4x2 b.b5x8 14.33022.60365YesNo085
79b.b19x2 b.b19x4 29.56962.52857YesYes168
80b.b15x2 b.b19x2 15.58065.22286YesYes166
81G.H2.04 G.H3.08 71.85833.14333YesNo099
82G.H2.06 b.l9x6 74.19543.41YesYes198
83G.H2.06 b.l17x6 72.6927.68048YesYes199
84G.S4.03 G.S5.03 21.05213.57619YesYes378
85G.H3.08 G.S4.04 71.49813.57778NoNo099
86G.S4.04 G.S4.06 50.60882.49524NoYes097
87G.H3.09 G.S4.04 20.618913.5097YesNo099
88G.S4.06 G.S5.06 20.22162.60159YesYes078
89G.H4.15 G.S4.06 28.40476.15746YesYes087
90G.S5.06 G.s4h3.01 18.92087.31556YesNo087
91G.HG.04 G.s4h3.01 18.537710.8251YesNo097
92G.HG.04 G.s4h3.04 10.29044.46889YesYes798
93G.HG.07 G.s4h3.04 14.21545.45841NoYes798
94G.HG.07 G.s4h3.06 13.35772.48429NoNo798
95G.H3.02 G.H4.15 11.63693.21825NoYes088
96G.H3.02 G.hgh4.01 11.20853.06NoYes086
97G.hgh4.01 G.s4h3.04 10.22463.73159YesYes068
98G.H3.01 G.s4h3.06 10.68964.39635YesNo798
99G.H3.06 G.hgh4.02 15.85853.62825NoYes067
100G.H5.10 G.S5.03 18.61973.25NoYes068
101G.H5.10 G.S6.02 17.76873.55651NoYes067
102G.H4.10 G.hgh4.02 10.47556.72762YesYes967
1032x39 3x50 77.88172.61778YesYes089
104b.b16x6 b.b17x3 10.84075.03619YesNo485
105b.b17x3 g.h1x10 15.39386.73286NoNo059
106g.h1x10 g.h1x13 16.93034.38222NoNo091
107b.b17x2 g.h1x13 17.42612.88794NoNo031
108b.b17x2 b.b17x4 18.34122.97254NoNo035
109b.b16x5 b.b17x4 19.86812.87175YesNo055
110b.b16x5 b.b17x5 11.61144.26556YesYes057
111b.1x19 b.b21x1 30.89456.04952NoYes067
112b.1x15 b.1x19 28.07184.41587NoNo076
113b.1x15 g.h1x15 26.64972.83603NoNo078
114b.1x11 g.h1x15 25.22530.926825YesNo088
115b.1x11 g.h1x12 13.7462.48429YesNo086
116g.h1x12 g.h1x9 13.02352.55NoNo066
117g.h1x5 g.h1x9 11.57693.17651NoNo066
118g.h1x1 g.h1x5 10.12793.85825YesNo026
119b.b20x5 b.b21x7 25.16655.13476NoYes075
120b.b20x5 b.b21x4 24.92314.63524NoNo075
121b.b20x7 b.b21x4 24.70853.21048YesNo095
122b.b20x7 b.l20x2 25.80053.36381YesYes099
123b.l20x2 g.l1x5 31.68455.41048YesNo094
124g.l1x3 g.l1x5 32.49130.2NoNo014
125g.l1x2 g.l1x3 33.30370.2YesNo021
126b.b21x1 g.l1x2 15.57393.4YesYes172
127b.l4x2 g.ctx16 13.59137.82492NoYes048
128b.b4x6 b.b5x3 15.004610.4768YesYes599
129b.b3x2 b.b4x6 19.99876.14397NoYes559
130b.b2x5 b.b3x2 20.34666.68905YesNo575
131b.b2x5 b.l26x1 24.37829.76381YesNo577
132b.l26x1 b.l26x3 24.79194.06206NoNo577
133b.l26x3 b.l26x5 27.17773.87206NoNo075
134b.l11x1 b.l9x6 24.20924.80714NoYes198
135b.b11x6 b.l11x1 23.79312.74095NoNo199
136b.b11x6 b.l9x3 20.474614.9003NoYes199
137b.b12x6 b.l9x3 16.26856.93651YesYes189
138b.b11x2 b.b12x6 13.96973.20317NoYes078
139b.b10x5 b.b11x2 13.49624.66603YesNo097
140b.b10x5 b.b8x3 11.11982.53206YesNo096
141b.b17x7 b.b19x2 10.499210.003YesYes186
142b.b20x4 b.b20x6 20.01134.25714YesYes186
143b.b20x2 b.b20x4 10.78076.65349NoYes068
1443x50 7x53 66.7815.14381YesYes299
1453x43 7x53 66.61524.56032YesYes299
1463x43 6x44 49.73262.84476YesYes299
1476x44 6x48 47.92826.90571YesYes298
1486x48 Lig 43.15813.01302YesYes280
149E2 Lig 10.62873.73825YesYes240
1502x46 2x50 14.20782.47698YesYes099
1512x46 3x43 16.58013.42778YesYes299
1521x39 2x57 12.61824.27444YesYes066
153b.b17x5 g.l1x2 17.58344.46746YesYes172
154b.b15x2 b.b16x5 11.07064.09159YesYes065
155b.b17x7 b.b21x1 31.3395.17429YesYes187
156b.b19x4 b.b20x6 10.0026.75143YesYes186
157b.b20x4 b.l17x3 10.77814.2044YesYes189
158b.b20x2 b.l19x2 10.8658.78492NoYes069
159G.H2.07 b.l9x6 33.61032.89397YesYes198
160b.b17x7 b.b20x6 29.40956.49905YesYes186
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
LigNT6.778892YesYes0601
2x60Lig9.003812NoYes5010
2x64Lig4.223970NoYes4010
3x29Lig7.779052YesYes5010
3x32Lig3.510482YesYes6010
3x33Lig11.76032YesYes5010
3x36Lig8.788732NoYes6010
3x37Lig6.001430NoYes6010
E2Lig3.738252YesYes4010
5x47Lig4.975242NoYes7010
6x48Lig3.013022YesYes8010
6x51Lig4.992062NoYes6010
6x55Lig4.044922NoYes6010
7x38Lig6.566190NoYes5010
NTNT30.64872YesYes6611
3x22NT6.50462NoYes3621
3x25NT4.055712YesYes9621
E2NT69.37892YesYes4611
E1x50NT2.795242NoYes5621
E1x501NT15.70222NoYes5621
E3NT6.430322YesYes2621
2x573x324.332380YesYes6621
2x577x387.851750YesNo6521
2x603x286.851432NoYes5612
2x603x323.628252NoYes5611
2x643x282.929050NoYes4612
E1x50E1x5013.59812NoNo5522
3x28E1x504.413972YesNo6522
3x253x287.619052YesYes9622
3x253x2910.76572YesYes9521
3x25E217.79672YesYes9421
3x26E215.90272NoYes6421
3x283x293.120792YesYes6521
3x29E212.78222YesYes5411
3x33E23.573172YesYes5411
3x335x397.760162YesYes5712
3x335x432.461592YesNo5611
3x366x485.096512NoYes6811
3x374x532.586670NoNo6812
3x405x502.834132NoNo7812
3x406x483.775712NoYes7811
4x594x602.761432NoNo5522
4x59E24.120952NoYes5421
4x595x395.040952NoYes5722
4x60E28.929842NoYes5421
4x605x3914.10862NoYes5722
5x36E26.606032NoYes4421
5x38E26.850322NoYes4421
5x39E29.915562YesYes7421
E2E242.02032YesYes4411
5x37E24.620160NoYes3421
5x40E22.512NoYes6421
6x58E212.66922NoYes4421
7x31E26.693332YesYes3421
5x365x386.304292NoNo4422
5x395x434.352222YesNo7621
5x406x552.621112NoNo6621
5x476x486.489212NoYes7811
5x476x5214.51192NoYes7612
6x446x486.905712YesYes9821
6x447x455.446512YesYes9922
6x487x4512.64522YesYes8912
6x516x555.143022NoNo6611
6x587x316.935712NoYes4322
E3E33.844292YesYes2222
7x31E34.386982YesYes3222
3x40Lig3.710162NoYes7010
3x253x264.025562YesNo9622
5x43Lig5.141592NoYes6010
7x32NT2.056190NoYes1621
6x487x411.852382YesNo8712
7x34E21.648890NoYes4421
2x563x321.462220NoYes4621
2x533x361.429520NoNo8621
4x63E21.37460NoYes5421
3x303x331.126510NoYes6521
2x64E1x471.119840NoNo4412

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
93.75Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
87.50Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
87.50Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
82.35Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
81.25Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
78.95Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
76.47Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
76.47Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
73.68Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
72.22Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
70.59Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
70.59Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
70.59Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
68.75Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
64.71Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
64.71Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
61.11Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
60.00Single5ZTYAM102575ZTY-CB2-AM10257
60.00Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
58.82Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
57.89Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
57.89Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
57.89Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
57.89Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
57.89Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
57.89Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
57.89Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
57.14Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
57.14Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
57.14Consensuslpl_onOrthosteric Ligands1p_on lpa_on
57.14Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
56.25Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
55.56Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
55.56Single9I52A1IZU9I52-D1-A1IZU-Gs/β1/γ2
55.00Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
55.00Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
55.00Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
55.00Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
52.94Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
52.63Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
52.63Single8E0GBU728E0G-μ-BU72
52.63Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
52.63Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
52.17Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
50.00Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
50.00Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
50.00Single7DFPSpiperone7DFP-D2-Spiperone
50.00Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
50.00Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
50.00Single7V68Iperoxo7V68-M4-Iperoxo-LY2119620-Gi1/β1/γ2
50.00Single7YITNalfurafine7YIT-κ-Nalfurafine
50.00Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
50.00Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
50.00Single9CHXS-Carazolol9CHX-β2-S-Carazolol
50.00Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
50.00Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
50.00Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
50.00Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
50.00Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
50.00Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
50.00Consensuslpa_offOrthosteric Ligandlpa1_off
50.00Consensuslpl_offOrthosteric Ligands1p_off lpa_off
48.00Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
47.62Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
47.62Single5X93K-87945X93-ETB-K-8794
47.62Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
47.62Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
47.62Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
47.62Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
47.62Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
47.62Single8S2TIsoprenaline8S2T-β1-Isoprenaline-chim(NtGi1-Gs)/β1/γ2
47.62Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
47.62Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
47.62Consensusendothelin_offOrthosteric Ligandetb_off
47.62Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
47.37Single5C1MBU725C1M-μ-BU72
47.37Single7C4SS1P7C4S-S1P3-S1P
47.37Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
47.37Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
47.37Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
47.37Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
47.37Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
47.37Single8TF5Oleic acid8TF5-GPR6-Oleic acid
47.37Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
47.37Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
47.37Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
47.37Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
47.37Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
47.37Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
47.37Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
47.37Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
47.37Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
47.37Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
47.37Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
47.06Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
47.06Single6AKXA4R6AKX-CCR5-A4R
47.06Single6B73MP11046B73-κ-MP1104
47.06Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
47.06Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
47.06Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
47.06Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
47.06Consensusorexin_offOrthosteric Ligandox2_off ox1_off
47.06Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
47.06Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
46.15Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
45.83Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
45.83Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
45.83Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
45.45Single4UG2CGS216804UG2-A2A-CGS21680
45.45Single7SK9CCX6627SK9-ACKR3-CCX662
45.45Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
45.45Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
45.45Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
45.45Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
45.45Single8X5YAstemizole8X5Y-H1-Astemizole
45.45Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
45.45Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
45.00Single2YDVNECA2YDV-A2A-NECA
45.00Single4DJHJDTic4DJH-κ-JDTic
45.00Single4UHRCGS216804UHR-A2A-CGS21680
45.00Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
45.00Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
45.00Single5G53NECA5G53-A2A-NECA-Gs
45.00Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
45.00Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
45.00Single6TQ7SB-3348676TQ7-OX1-SB-334867
45.00Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
45.00Single7FEECP559407FEE-CB1-CP55940-ZCZ011
45.00Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
45.00Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
45.00Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
45.00Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
45.00Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
45.00Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
45.00Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
45.00Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
45.00Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
45.00Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
45.00Single9I54A1IZV9I54-D1-A1IZV-Gs/β1/γ2
45.00Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
45.00Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
45.00Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
45.00Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
45.00Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
45.00Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
45.00Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
45.00Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
45.00Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
45.00Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
45.00Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
44.44Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
44.44Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
44.44Single4MBSMaraviroc4MBS-CCR5-Maraviroc
44.44Single4ZJCSB-6740424ZJC-OX1-SB-674042
44.44Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
44.44Single6TPGEMPA6TPG-OX2-EMPA
44.44Single6TPNHTL66416TPN-OX2-HTL6641
44.44Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
44.44Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
44.44Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
44.44Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
44.44Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
44.44Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
44.44Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
44.44Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
44.44Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
44.44Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
44.44Single9M2FNeuropeptide FF9M2F-NPFF1-Neuropeptide FF-Gi1/β1/γ2
44.44Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
44.44Consensusalpha1_onOrthosteric Ligandalpha1a_on
44.44Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
44.44Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
44.44Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
44.44Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
44.44Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
44.44Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
44.00Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
44.00Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
43.48Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
43.48Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
43.48Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
43.48Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
43.48Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
43.48Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
42.86Single3D4STimolol3D4S-β2-Timolol
42.86Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
42.86Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
42.86Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
42.86Single6KQICP559406KQI-CB1-CP55940-Org27569
42.86Single6ZG4HTL00099366ZG4-M1-HTL0009936
42.86Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
42.86Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
42.86Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
42.86Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
42.86Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
42.86Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
42.86Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
42.86Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
42.86Single8JD3JNJ-404118138JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
42.86Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
42.86Single9DGIZ85267113509DGI-CB1-Z8526711350
42.86Single9EBIPiclidenoson9EBI-A3A-Piclidenoson-chim(NtGi1L-Gs-CtGi1)/β1/γ2
42.86Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
42.86Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
42.86Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
42.86Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
42.86Consensusalpha1_offOrthosteric Ligandalpha1a_off
42.86Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
42.86Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
42.86Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
42.86Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
42.86Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
42.86Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
42.86Consensusorexin_onOrthosteric Ligandox2_on
42.31Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
42.31Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
42.11Single3NY8ICI118-5513NY8-β2-ICI118-551
42.11Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
42.11Single4EJ4Naltrindole4EJ4-δ-Naltrindole
42.11Single4GBRS-Carazolol4GBR-β2-S-Carazolol
42.11Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
42.11Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
42.11Single6TOTLemborexant6TOT-OX1-Lemborexant
42.11Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
42.11Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
42.11Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
42.11Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
42.11Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
42.11Single7UL4Alvimopan7UL4-μ-Alvimopan
42.11Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
42.11Single7V3ZCP559407V3Z-CB1-CP55940
42.11Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
42.11Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
42.11Single8T1WCVN4248T1W-GPR6-CVN424
42.11Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
42.11Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
42.11Single8X63Mepyramine8X63-H1-Mepyramine
42.11Single8X64Desloratadine8X64-H1-Desloratadine
42.11Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
42.11Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
42.11Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
42.11Single9PLNN-(5-methylnaphthalen-1-yl)pyridin-4-amine9PLN-α2a-N-(5-methylnaphthalen-1-yl)pyridin-4-amine
42.11Single9PLON-(5-methylnaphthalen-1-yl)pyridin-4-amine9PLO-α2a-N-(5-methylnaphthalen-1-yl)pyridin-4-amine-Go/β1/γ2
42.11Single9PQD(6m)-1-methyl-6-(1,2,5,6-tetrahydropyridin-3-yl)-1h-indole9PQD-α2a-(6m)-1-methyl-6-(1,2,5,6-tetrahydropyridin-3-yl)-1h-indole
42.11Consensus5ht5_onOrthosteric Ligand5ht5a_on
42.11Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
42.11Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
42.11Consensusalpha2_onOrthosteric Ligandalpha2b_on
42.11Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
42.11Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
42.11Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
42.11Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
42.11Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
42.11Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
42.11Consensusblt_onOrthosteric Ligandblt1_on
42.11Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
42.11Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
42.11Consensusdopamine_offOrthosteric Ligandd2_off d3_off
42.11Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
42.11Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
42.11Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
42.11Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
42.11Consensushistamine_offOrthosteric Ligandh1_off
42.11Consensusleukotriene_onOrthosteric Ligandblt_on
42.11Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
41.67Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
41.18Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
41.18Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
41.18Single7SRQLSD7SRQ-5-HT2B-LSD
41.18Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
41.18Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
41.18Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
41.18Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
40.91Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
40.91Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
40.91Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
40.91Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
40.91Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
40.91Single7UM4AS26747237UM4-5-HT5A-AS2674723
40.91Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
40.91Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
40.91Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
40.91Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
40.91Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
40.91Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
40.91Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
40.91Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
40.91Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
40.91Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
40.91Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
40.91Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
40.91Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
40.91Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
40.74Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
40.00Single2RH1S-Carazolol2RH1-β2-S-Carazolol
40.00Single2YCWS-Carazolol2YCW-β1-S-Carazolol
40.00Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
40.00Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
40.00Single5D6LS-Carazolol5D6L-β2-S-Carazolol
40.00Single5WQCEMPA5WQC-OX2-EMPA
40.00Single5X7DS-Carazolol5X7D-β2-S-Carazolol-Cmpd-15
40.00Single5XPRBosentan5XPR-ETB-Bosentan
40.00Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
40.00Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
40.00Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
40.00Single6TP6Filorexant6TP6-OX1-Filorexant
40.00Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
40.00Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
40.00Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
40.00Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
40.00Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
40.00Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
40.00Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
40.00Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
40.00Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
40.00Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
40.00Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
40.00Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
40.00Single8JXSPF-61428JXS-D1-PF-6142
40.00Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
40.00Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
40.00Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
40.00Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
40.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
40.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
40.00Single9DYDAsenapine9DYD-5-HT1A-Asenapine-Go/β1/γ2
40.00Single9DYFAsenapine9DYF-5-HT1A-Asenapine-Gi1/β1/γ2
40.00Single9EE8Adenosine9EE8-A2A-Adenosine-Gs/β1/γ2
40.00Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
40.00Single9K07DSO-5a9K07-BB3-DSO-5a-chim(NtGi2L-Gs-CtGq)/β1/γ2
40.00Single9U4WGonadoliberin-19U4W-GnRH1-Gonadoliberin-1-chim(NtGi1L-Gs-CtGq)/β1/γ2
40.00Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
40.00Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
40.00Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
40.00Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
40.00Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
40.00Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
40.00Consensusamine_offonOrthosteric Ligandamine_off amine_on
40.00Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
40.00Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
40.00Consensusangiotensin_onOrthosteric Ligandat1_on
40.00Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
40.00Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
40.00Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
40.00Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
40.00Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
40.00Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
40.00Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
40.00Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
40.00Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
40.00Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
40.00Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
40.00Consensustrace-amine_onOrthosteric Ligandta1_on
39.29Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
39.29Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
39.13Single3NY9ICI118-5513NY9-β2-ICI118-551
39.13Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
39.13Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
39.13Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
39.13Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
39.13Single8QJ2pN1628QJ2-MC4-pN162-Gs
39.13Single8Y72Peptide8Y72-μ-Peptide-BMS-986122-Gi1/β1/γ2
39.13Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
38.89Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
38.89Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
38.89Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
38.89Single5WS3EMPA5WS3-OX2-EMPA
38.89Single6AKYMaraviroc6AKY-CCR5-Maraviroc
38.89Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
38.89Single6TODEMPA6TOD-OX1-EMPA-Na
38.89Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
38.89Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
38.89Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
38.89Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
38.89Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
38.89Single7XRRLemborexant7XRR-OX2-Lemborexant
38.89Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
38.89Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
38.89Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
38.89Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
38.89Single8Y0HVUF114188Y0H-CXCR3-VUF11418
38.89Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go/β1/γ2
38.89Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
38.89Single8YYWAlpha-ketoglutarate8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
38.89Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
38.89Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
38.89Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
38.89Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
38.89Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
38.89Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
38.89Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
38.89Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
38.46Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
38.46Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
38.46Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
38.46Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
38.46Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
38.46Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
38.46Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
38.46Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
38.10Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
38.10Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
38.10Single4U15Tiotropium4U15-M3-Tiotropium
38.10Single5D5AS-Carazolol5D5A-β2-S-Carazolol
38.10Single5D5BS-Carazolol5D5B-β2-S-Carazolol
38.10Single5V54Methiothepin5V54-5-HT1B-Methiothepin
38.10Single5XR8AM8415XR8-CB1-AM841
38.10Single5XRAAM115425XRA-CB1-AM11542
38.10Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
38.10Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
38.10Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
38.10Single6H7JIsoprenaline6H7J-β1-Isoprenaline
38.10Single6J21Aprepitant6J21-NK1-Aprepitant
38.10Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
38.10Single6OL9Tiotropium6OL9-M5-Tiotropium
38.10Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
38.10Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
38.10Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
38.10Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
38.10Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
38.10Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
38.10Single8EA0Iperoxo8EA0-M3-Iperoxo
38.10Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
38.10Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
38.10Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
38.10Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
38.10Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
38.10Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
38.10Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
38.10Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
38.10Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
38.10Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
38.10Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
38.10Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
38.10Single8XVLZibotentan8XVL-ETA-Zibotentan
38.10Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
38.10Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
38.10Single9BJKNaloxone9BJK-μ-Naloxone-NAM
38.10Single9EGOYVF9EGO-CB1-YVF-Gi1/β1/γ2
38.10Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
38.10Consensus5ht1_offOrthosteric Ligand5ht1b_off
38.10Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
38.10Consensusa2_onOrthosteric Liganda2b_on
38.10Consensusa2_on_gpOrthosteric Liganda2b_on_gp
38.10Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
38.10Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
38.10Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
38.10Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
38.10Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
38.10Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
38.10Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
38.10Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
38.10Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
38.10Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
37.93Single6IGLIRL16206IGL-ETB-IRL1620
37.50Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
37.50Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
37.50Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
37.50Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
37.50Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
37.50Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
37.50Single8PKMBefiradol8PKM-5-HT1A-Befiradol-Gi1/β1/γ1
37.50Single8WDTphotoNECA8WDT-A2A-photoNECA
37.50Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
37.50Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
37.04Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
37.04Single8ZRTET-18ZRT-ETB-ET-1
37.04Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
37.04Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
36.84Single2YDOAdenosine2YDO-A2A-Adenosine
36.84Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
36.84Single3RZECidoxepin3RZE-H1-Cidoxepin
36.84Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
36.84Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
36.84Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
36.84Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
36.84Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
36.84Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
36.84Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
36.84Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
36.84Single6PS0S-Carazolol6PS0-β2-S-Carazolol
36.84Single6PS4ICI118-5516PS4-β2-ICI118-551
36.84Single6PS5S-Propranolol6PS5-β2-S-Propranolol
36.84Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
36.84Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
36.84Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
36.84Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
36.84Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
36.84Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
36.84Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
36.84Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
36.84Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
36.84Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
36.84Single7F61PF-036547467F61-H3-PF-03654746
36.84Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
36.84Single7UL3Famotidine7UL3-H2-Famotidine
36.84Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
36.84Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
36.84Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
36.84Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
36.84Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
36.84Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
36.84Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
36.84Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
36.84Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
36.84Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
36.84Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
36.84Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
36.84Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
36.84Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
36.84Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
36.84Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
36.84Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
36.84Single8K5CAcipimox8K5C-HCA2-Acipimox
36.84Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
36.84Single8RLNLUF58348RLN-A2A-LUF5834
36.84Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
36.84Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
36.84Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
36.84Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
36.84Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
36.84Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
36.84Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
36.84Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
36.84Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
36.84Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
36.84Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
36.84Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
36.84Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
36.84Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
36.84Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
36.84Single9JMDAzithromycin9JMD-Motilin-Azithromycin-chim(Gs-CtGq)/β1/γ2
36.84Single9LRDHistamine9LRD-H1-Histamine-Gi1/β1/γ2
36.84Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
36.84Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
36.84Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
36.84Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
36.84Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
36.84Consensushca_onOrthosteric Ligandhca2_on
36.84Consensusopsins_offOrthosteric Ligandrhodopsin_off
36.84Consensussensory_offOrthosteric Ligandopsins_off
36.67Single5GLHEndothelin-15GLH-ETB-Endothelin-1
36.67Single6IGKEndothelin-36IGK-ETB-Endothelin-3
36.67Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
36.67Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
36.67Consensusbombesin_onOrthosteric Ligandbb2_on
36.67Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
36.67Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
36.36Single4AMIBucindolol4AMI-β1-Bucindolol
36.36Single4LDEBI1671074LDE-β2-BI167107
36.36Single4RWADIPP-NH24RWA-δ-DIPP-NH2
36.36Single5CXVTiotropium5CXV-M1-Tiotropium
36.36Single6A93Risperidone6A93-5-HT2A-Risperidone
36.36Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
36.36Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
36.36Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
36.36Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
36.36Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
36.36Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
36.36Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
36.36Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
36.36Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
36.36Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
36.36Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
36.36Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
36.36Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
36.36Single8JWY2-1188JWY-A2A-2-118
36.36Single8JWZAB9288JWZ-A2A-AB928-Na
36.36Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
36.36Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
36.36Single8XYIVUF106618XYI-CXCR3-VUF10661
36.36Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
36.36Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
36.36Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
36.36Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
36.36Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
36.36Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
36.00Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
36.00Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
36.00Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
36.00Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
36.00Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
35.71Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
35.48Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
35.48Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
35.29Single3PQRAll-trans-Retinal3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
35.29Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
35.29Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
35.29Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
35.29Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
35.29Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
35.29Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
35.29Consensus5ht2_onOrthosteric Ligand5ht2b_on
35.29Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
35.29Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
35.00Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
35.00Single2Y04Salbutamol2Y04-β1-Salbutamol
35.00Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
35.00Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
35.00Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
35.00Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
35.00Single4MQSIperoxo4MQS-M2-Iperoxo
35.00Single4U14Tiotropium4U14-M3-Tiotropium
35.00Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
35.00Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
35.00Single5TGZAM65385TGZ-CB1-AM6538
35.00Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
35.00Single6DRXLisuride6DRX-5-HT2B-Lisuride
35.00Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
35.00Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
35.00Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
35.00Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
35.00Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
35.00Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
35.00Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
35.00Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
35.00Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
35.00Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
35.00Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
35.00Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
35.00Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
35.00Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
35.00Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
35.00Single7WC7Lisuride7WC7-5-HT2A-Lisuride
35.00Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
35.00Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
35.00Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
35.00Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
35.00Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
35.00Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
35.00Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
35.00Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
35.00Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
35.00Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
35.00Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
35.00Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
35.00Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
35.00Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
35.00Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
35.00Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
35.00Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
35.00Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
35.00Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
35.00Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
35.00Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
35.00Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
35.00Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
35.00Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
35.00Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
35.00Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
35.00Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
35.00Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
35.00Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
35.00Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
35.00Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
35.00Single8JJOAlprenolol8JJO-β2-Alprenolol
35.00Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
35.00Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
35.00Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
35.00Single8JXRLSD8JXR-D1-LSD
35.00Single8PJKST1718PJK-5-HT1A-ST171-Gi1/β1/γ1
35.00Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
35.00Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
35.00Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
35.00Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
35.00Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
35.00Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
35.00Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
35.00Single9AS1DMT9AS1-5-HT2A-DMT
35.00Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
35.00Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
35.00Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
35.00Single9JEAAtropine9JEA-M1-Atropine
35.00Single9KFJPubChem 1383196749KFJ-RXFP3-PubChem 138319674-Gi2/β1/γ2
35.00Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
35.00Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
35.00Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
35.00Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
35.00Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
35.00Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
35.00Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
35.00Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
35.00Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
35.00Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
35.00Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
35.00Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
35.00Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
35.00Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
35.00Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
35.00Consensushca_on_gpOrthosteric Ligandhca2_on_gp
35.00Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
35.00Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
34.78Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
34.78Single6K1QIRL25006K1Q-ETB-IRL2500
34.78Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
34.78Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
34.78Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
34.78Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
34.78Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
34.78Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
34.78Single8ZWGJR14a8ZWG-C3aB-JR14a-Gi1/β1/γ2
34.78Single9AS02-bromo-LSD9AS0-5-HT2A-2-bromo-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
34.78Single9CGJC6-Quino9CGJ-δ-C6-Quino-Gi1/β1/γ2
34.78Single9DYEBuspirone9DYE-5-HT1A-Buspirone-Go/β1/γ2
34.78Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
34.78Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
34.62Single5WF5UK-4320975WF5-A2A-UK-432097
34.62Single6PT2KGCHM076PT2-δ-KGCHM07
34.62Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
34.62Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
34.62Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
34.62Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
34.62Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
34.62Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
34.62Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
34.48Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
34.48Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
34.48Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
34.48Single9KDFRES-701-39KDF-ETB-RES-701-3
34.38Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
34.38Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
34.29Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
33.33Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
33.33Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
33.33Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
33.33Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
33.33Single2Y03Isoprenaline2Y03-β1-Isoprenaline
33.33Single5JQHS-Carazolol5JQH-β2-S-Carazolol
33.33Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
33.33Single5TVNLSD5TVN-5-HT2B-LSD
33.33Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
33.33Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
33.33Single6E67BI1671076E67-β2-BI167107-Gs(CT)
33.33Single6JODAngiotensin II6JOD-AT2-Angiotensin II
33.33Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
33.33Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
33.33Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
33.33Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
33.33Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
33.33Single6PS6Timolol6PS6-β2-Timolol
33.33Single6PT3DPI-2876PT3-δ-DPI-287
33.33Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
33.33Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
33.33Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
33.33Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
33.33Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
33.33Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
33.33Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
33.33Single7LD3Adenosine7LD3-A1-Adenosine-MIPS521-Gi2/β1/γ2
33.33Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
33.33Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
33.33Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
33.33Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
33.33Single7W41PD1762527W41-BB2-PD176252
33.33Single7WC6LSD7WC6-5-HT2A-LSD
33.33Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
33.33Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
33.33Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
33.33Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
33.33Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
33.33Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
33.33Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
33.33Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
33.33Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
33.33Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
33.33Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
33.33Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
33.33Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
33.33Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
33.33Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
33.33Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
33.33Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
33.33Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
33.33Single8K5BNiacin8K5B-HCA2-Niacin
33.33Single8S4DCMF-0198S4D-Apelin-CMF-019
33.33Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
33.33Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
33.33Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
33.33Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
33.33Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
33.33Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
33.33Single8XYKVUF106618XYK-CXCR3-VUF10661-Go/β1/γ2
33.33Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
33.33Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
33.33Single8ZBISomatostatin-148ZBI-SST3-Somatostatin-14-Gi1/β1/γ2
33.33Single8ZMFA1L108ZMF-5-HT2C-A1L10
33.33Single9ARYSerotonin9ARY-5-HT2A-Serotonin-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single9ARZ2-bromo-LSD9ARZ-5-HT2A-2-bromo-LSD
33.33Single9BYOExendin-39BYO-GLP-1-Exendin-3-Gs/β1/γ2
33.33Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
33.33Single9CGKC5-Quino9CGK-δ-C5-Quino-Gi1/β1/γ2
33.33Single9CIBFCH-22964139CIB-HCA2-FCH-2296413
33.33Single9EHSLUF76029EHS-A3A-LUF7602
33.33Single9F33FOB02-04A9F33-D3-FOB02-04A-Go/β1/γ2
33.33Single9GE2ML1849GE2-GPR55-ML184-chim(NtGi1-G13)/β1/γ2
33.33Single9HAPTolvaptan9HAP-V2-Tolvaptan
33.33Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
33.33Single9IPVJR14a9IPV-C3aB-JR14a-Gi1/β1/γ2
33.33Single9IXJHistamine9IXJ-H2-Histamine-Gs/β1/γ2
33.33Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
33.33Single9M0RNeuropeptide VF9M0R-NPFF1-Neuropeptide VF-Gi1/β1/γ2
33.33Consensusa3_on_gpOrthosteric Liganda3a_on_gp
33.33Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
33.33Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
33.33Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
33.33Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
33.33Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
33.33Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
33.33Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
33.33Consensusbombesin_offOrthosteric Ligandbb2_off
33.33Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
33.33Consensusendothelin_onOrthosteric Ligandetb_on eta_on
33.33Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
33.33Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
33.33Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
33.33Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
33.33Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
33.33Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
33.33Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
33.33Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
33.33Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
33.33Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
33.33Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
33.33Consensusvasop-oxy_onOrthosteric Ligandv2_on
33.33Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
32.43Consensuspth_on_gpOrthosteric Ligandpth1_on_gp pth2_on_gp
32.35Consensuspth_onOrthosteric Ligandpth1_on pth2_on
32.14Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
32.14Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
32.14Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
32.14Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
32.14Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
32.14Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
32.14Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
32.14Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
32.14Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
32.14Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
32.00Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
32.00Single4IARErgotamine4IAR-5-HT1B-Ergotamine
32.00Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
32.00Single4XT1Fractalkine4XT1-US28-Fractalkine
32.00Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
32.00Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
32.00Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
32.00Single8IEBA1LYA8IEB-GPR156-A1LYA
32.00Single8WKYPG-9348WKY-MC4-PG-934
32.00Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
32.00Single9BUYLM1899BUY-β2-LM189-Gi1/β1/γ2
32.00Single9M4TSilodosin9M4T-Alpha1A-Silodosin
32.00Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
32.00Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
32.00Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
32.00Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
31.82Single3P0GBI1671073P0G-β2-BI167107
31.82Single6E59L-7607356E59-NK1-L-760735
31.82Single6J20Aprepitant6J20-NK1-Aprepitant
31.82Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
31.82Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
31.82Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
31.82Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
31.82Single6WGTLSD6WGT-5-HT2A-LSD
31.82Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
31.82Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
31.82Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
31.82Single7TUYGSK682753A7TUY-GPR183-GSK682753A
31.82Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
31.82Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
31.82Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
31.82Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
31.82Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
31.82Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
31.82Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
31.82Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
31.82Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
31.82Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
31.82Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
31.82Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
31.82Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
31.82Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
31.82Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
31.82Single8Y73Peptide8Y73-μ-Peptide-MPAM-15-Gi1/β1/γ2
31.82Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
31.82Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
31.82Single9JMCDS-3801b9JMC-Motilin-DS-3801b-chim(Gs-CtGq)/β1/γ2
31.82Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
31.82Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
31.82Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
31.82Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
31.82Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
31.82Consensuslpa_onOrthosteric Ligandlpa1_on
31.82Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
31.82Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
31.82Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
31.58Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
31.58Single4S0VSuvorexant4S0V-OX2-Suvorexant
31.58Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
31.58Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
31.58Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
31.58Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
31.58Single6TPJSuvorexant6TPJ-OX2-Suvorexant
31.58Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
31.58Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
31.58Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
31.58Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
31.58Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
31.58Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
31.58Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
31.58Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
31.58Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
31.58Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
31.58Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
31.58Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
31.58Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
31.58Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
31.58Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
31.58Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
31.58Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
31.58Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
31.58Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
31.58Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
31.58Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
31.58Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
31.58Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.58Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.58Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
31.58Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
31.58Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
31.58Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
31.58Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
31.58Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
31.58Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
31.58Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
31.58Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.58Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.58Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.58Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
31.58Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
31.58Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
31.58Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ2
31.58Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
31.58Single9EEAAdenosine9EEA-A2A-Adenosine-Gs/β1/γ2
31.58Single9KPESA09KPE-TAS2R16-SA0-Gi1/β1/γ2
31.58Single9LRBHistamine9LRB-H1-Histamine-Gs/β1/γ2
31.58Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
31.58Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
31.58Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
31.58Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
31.58Consensusalpha2_offOrthosteric Ligandalpha2c_off
31.58Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
31.58Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
31.58Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
31.58Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
31.58Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
31.58Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
31.58Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
31.58Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
31.58Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
31.58Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
31.43Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
31.43Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
31.25Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
31.25Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
31.03Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
31.03Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
31.03Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
31.03Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
31.03Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
30.77Single3QAKUK-4320973QAK-A2A-UK-432097
30.77Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
30.77Single6HLOAprepitant6HLO-NK1-Aprepitant
30.77Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
30.77Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
30.77Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
30.77Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
30.77Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
30.77Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
30.77Single9E82SDF-1-beta9E82-ACKR3-SDF-1-β-Arrestin2
30.77Single9IK8SST analogue9IK8-SST1-SST analogue-Gi1/β1/γ2
30.77Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
30.77Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
30.77Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
30.77Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
30.77Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
30.77Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
30.77Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
30.77Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
30.43Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
30.43Single4N4WSANT-14N4W-SMO-SANT-1
30.43Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
30.43Single6CM4Risperidone6CM4-D2-Risperidone
30.43Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
30.43Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
30.43Single6MXTSalmeterol6MXT-β2-Salmeterol
30.43Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
30.43Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
30.43Single7K15MKD0467K15-BLT1-MKD046-Na
30.43Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
30.43Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
30.43Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
30.43Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
30.43Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
30.43Single8JJ8Formoterol8JJ8-β2-Formoterol
30.43Single8JJLOlodaterol8JJL-β2-Olodaterol
30.43Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
30.43Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
30.43Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
30.43Single9GL2Befiradol9GL2-5-HT1A-Befiradol-Gs/β1/γ2
30.43Single9M4QDoxazosin9M4Q-Alpha1A-Doxazosin
30.43Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
30.43Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
30.43Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
30.43Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
30.43Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
30.43Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
30.43Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
30.43Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
30.43Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
30.43Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
30.30Consensuscrf_on_gpOrthosteric Ligandcrf2_on_gp crf1_on_gp
30.00Single6A94Zotepine6A94-5-HT2A-Zotepine
30.00Single6IQLL7458706IQL-D4-L745870
30.00Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
30.00Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
30.00Single6TP3Nemorexant6TP3-OX1-Nemorexant
30.00Single6TPKRetosiban6TPK-OT-Retosiban
30.00Single6V9SGTPL114036V9S-OX1-GTPL11403
30.00Single6VI4JDTic6VI4-κ-JDTic
30.00Single6ZG9GSK10347026ZG9-M1-GSK1034702
30.00Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
30.00Single7T94Acetylcholine7T94-M2-Acetylcholine-LY2119620-chim(NtGi1-Go)/β1/γ2
30.00Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
30.00Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
30.00Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
30.00Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
30.00Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
30.00Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
30.00Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
30.00Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
30.00Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
30.00Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
30.00Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
30.00Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
30.00Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
30.00Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
30.00Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.00Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
30.00Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
30.00Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
30.00Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
30.00Single8IHKAcifran8IHK-HCA3-Acifran
30.00Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
30.00Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
30.00Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
30.00Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
30.00Single8K9LDamgo8K9L-μ-Damgo-BMS-986122-Gi3/β1/γ1
30.00Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
30.00Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
30.00Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.00Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.00Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
30.00Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
30.00Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
30.00Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
30.00Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
30.00Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
30.00Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
30.00Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
30.00Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
30.00Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
30.00Single9ARXSerotonin9ARX-5-HT2A-Serotonin
30.00Single9AS5Mescaline9AS5-5-HT2A-Mescaline
30.00Single9AS6Mescaline9AS6-5-HT2A-Mescaline-chim(NtGi1-Gs-CtGq)/β1/γ2
30.00Single9BUCCagrilintide9BUC-CT-Cagrilintide-Gs/β1/γ2
30.00Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
30.00Single9KPDSA09KPD-TAS2R16-SA0-chim(Gs-CtGt3)/β1/γ2
30.00Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
30.00Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
30.00Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
30.00Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
30.00Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
30.00Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
30.00Consensusvasop-oxy_offOrthosteric Ligandot_off
29.63Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
29.63Single6W25SHU91196W25-MC4-SHU9119-Ca
29.63Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
29.63Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
29.63Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
29.63Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
29.63Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
29.63Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
29.41Single2HPYAll-trans-Retinal2HPY-Rhodopsin-All-trans-Retinal
29.41Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
29.41Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
29.41Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
29.41Single8IWM2-Phenylethylamine8IWM-TA9-2-Phenylethylamine
29.41Single8WC5Tetramethylammonium Ion8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
29.41Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
29.41Single9CHUNoradrenaline9CHU-β2-Noradrenaline
29.41Consensusclass-a_class-b1_cons_on_gpOrthosteric Ligandclass-a_on_gp class-b1_on_gp
29.41Consensusgs_histamineOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
29.41Consensush2_onOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
29.17Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
29.17Single6H7LDobutamine6H7L-β1-Dobutamine
29.17Single6IBLArformoterol6IBL-β1-Arformoterol
29.17Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
29.17Single7EZCUKA7EZC-A2A-UKA
29.17Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
29.17Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
29.17Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
29.17Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
29.17Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
29.17Single8T3OTUG-8918T3O-FFA4-TUG-891-chim(NtGi2L-Gs-CtGq)/β1/γ2
29.17Single8XVJMacitentan8XVJ-ETA-Macitentan
29.17Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
29.17Single9C0KExendin-49C0K-GLP-1-Exendin-4-Gs/β1/γ2
29.17Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
29.17Single9M54Neuropeptide VF9M54-NPFF2-Neuropeptide VF-Gi1/β1/γ2
29.17Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
29.17Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
29.17Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
29.17Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
29.17Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
29.17Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
29.17Consensusprostanoid_offOrthosteric Ligandep_off dp_off
29.03Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
29.03Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
29.03Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
29.03Single8IY6Endothelin-18IY6-ETB-Endothelin-1
29.03Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
29.03Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
29.03Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
29.03Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
29.03Consensusbradykinin_onOrthosteric Ligandbk2_on
29.03Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
29.03Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
28.57Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
28.57Single2Y02Carmoterol2Y02-β1-Carmoterol
28.57Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
28.57Single4DAJTiotropium4DAJ-M3-Tiotropium
28.57Single4QKX35V4QKX-β2-35V
28.57Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
28.57Single4YAYZD-71554YAY-AT1-ZD-7155
28.57Single5DHGC-355DHG-NOP-C-35
28.57Single5DHHSB-6121115DHH-NOP-SB-612111
28.57Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
28.57Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
28.57Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
28.57Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
28.57Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
28.57Single6H7MSalbutamol6H7M-β1-Salbutamol
28.57Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
28.57Single6PS1Timolol6PS1-β2-Timolol
28.57Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
28.57Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
28.57Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
28.57Single6XBM5LWE6XBM-SMO-5LWE-Gi1/β1/γ2
28.57Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
28.57Single7BU7BI1671077BU7-β1-BI167107
28.57Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
28.57Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
28.57Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
28.57Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
28.57Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
28.57Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
28.57Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
28.57Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
28.57Single8CU6LJ-45178CU6-A2A-LJ-4517
28.57Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
28.57Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
28.57Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
28.57Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
28.57Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
28.57Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
28.57Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
28.57Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
28.57Single8K5DGSK2560738K5D-HCA2-GSK256073
28.57Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
28.57Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
28.57Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
28.57Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
28.57Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
28.57Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
28.57Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
28.57Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Single9H37A1IR09H37-A2A-A1IR0-Na
28.57Single9IYAONO-97105319IYA-GPR55-ONO-9710531
28.57Single9IZCMK19039IZC-HCA2-MK1903-Gi1/β1/γ2
28.57Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
28.57Consensusa3_onOrthosteric Liganda3a_on
28.57Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
28.57Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
28.57Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
28.12Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
28.12Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
28.12Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
28.12Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
28.12Consensusclass-a_class-b1_cons_onOrthosteric Ligandclass-a_on class-b1_on
28.12Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
28.12Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
28.12Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
28.12Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
28.00Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
28.00Single5WF6UK-4320975WF6-A2A-UK-432097
28.00Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
28.00Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
28.00Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
28.00Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
28.00Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
28.00Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
28.00Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
28.00Single9IPYJR14a9IPY-C3aB-JR14a
28.00Single9IZASCH9002719IZA-HCA2-SCH900271-Gi1/β1/γ2
28.00Single9MD1Buspirone9MD1-5-HT1A-Buspirone-Gz/β1/γ2
28.00Single9V2NMacimorelin9V2N-Ghrelin-Macimorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
28.00Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
28.00Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
28.00Consensuskisspeptin_onOrthosteric Ligandkiss1_on
27.78Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
27.78Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
27.78Single3OE6IT1t3OE6-CXCR4-IT1t
27.78Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
27.78Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
27.78Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
27.78Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
27.78Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
27.78Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.78Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.78Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
27.78Single8IW72-Phenylethylamine8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
27.78Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
27.78Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
27.78Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
27.78Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
27.78Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
27.78Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
27.78Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
27.78Single9LRCHistamine9LRC-H4-Histamine
27.78Single9LREHistamine9LRE-H4-Histamine-Gi1/β1/γ2
27.78Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
27.78Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
27.78Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
27.78Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
27.78Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
27.59Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
27.59Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
27.59Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
27.59Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
27.59Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
27.59Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
27.59Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
27.59Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
27.59Single9JFYhNPSF9JFY-NPFF2-hNPSF-Gi1/β1/γ2
27.59Consensusvpac1_onOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
27.27Single5N2RPSB-365N2R-A2A-PSB-36-Na
27.27Single5N2SPSB365N2S-A1-PSB36
27.27Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
27.27Single5WIUNemonapride5WIU-D4-Nemonapride
27.27Single5WIVNemonapride5WIV-D4-Nemonapride-Na
27.27Single6D26Fevipiprant6D26-DP2-Fevipiprant
27.27Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
27.27Single6HLPNetupitant6HLP-NK1-Netupitant
27.27Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
27.27Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
27.27Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
27.27Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
27.27Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
27.27Single7C61Ergotamine7C61-5-HT1B-Ergotamine
27.27Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
27.27Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
27.27Single7SINNPS-21437SIN-CaS-NPS-2143
27.27Single7SINNPS-21437SIN-CaS-NPS-2143
27.27Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
27.27Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
27.27Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
27.27Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
27.27Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
27.27Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
27.27Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
27.27Single8WGBVU01550418WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
27.27Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
27.27Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
27.27Single9F34FOB02-04A9F34-D3-FOB02-04A-Go/β1/γ2
27.27Single9KPFSA09KPF-TAS2R16-SA0-Gi1/β1/γ2
27.27Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
27.27Consensusadenosine_offOrthosteric Liganda1_off a2_off
27.27Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
27.27Consensusblt_offOrthosteric Ligandblt1_off
27.27Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
27.27Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
27.27Consensusdp_offOrthosteric Liganddp2_off
27.27Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
27.27Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
27.27Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
27.27Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
27.27Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
27.27Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
27.27Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
27.03Consensuspth2_on_gpOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
26.92Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
26.92Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
26.92Single7QA8Peptide7QA8-STE2-Peptide
26.92Single7QA8Peptide7QA8-STE2-Peptide
26.92Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
26.92Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
26.92Single8IEIA1LYA8IEI-GPR156-A1LYA
26.92Single8IEIA1LYA8IEI-GPR156-A1LYA
26.92Single8IEPA1LYA8IEP-GPR156-A1LYA
26.92Single8IEPA1LYA8IEP-GPR156-A1LYA
26.92Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
26.92Single8U4OCXCL128U4O-CXCR4-CXCL12-Gi1/β1/γ2
26.92Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
26.92Single8ZBJSomatostatin-148ZBJ-SST5-Somatostatin-14-Gi1/β1/γ2
26.92Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
26.92Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
26.92Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
26.92Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
26.92Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
26.92Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
26.92Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
26.92Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
26.92Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
26.92Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
26.92Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
26.83Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
26.67Single4XT3Fractalkine4XT3-US28-Fractalkine
26.67Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
26.67Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
26.67Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
26.67Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
26.67Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
26.67Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
26.67Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
26.67Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
26.67Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
26.67Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
26.67Single9BLWCagrilintide backbone (non-acylated)9BLW-CT (AMY1)-Cagrilintide backbone (non-acylated)-Gs/β1/γ2; RAMP1
26.67Single9KFKRelaxin-39KFK-RXFP4-Relaxin-3-Gi2/β1/γ2
26.67Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
26.67Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
26.67Consensuspac_on_gpOrthosteric Ligandpac1_on_gp
26.67Consensusvpac1_on_gpOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
26.47Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
26.47Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
26.47Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
26.32Single3OE9IT1t3OE9-CXCR4-IT1t
26.32Single3PBLEticlopride3PBL-D3-Eticlopride
26.32Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
26.32Single6HLLCP999946HLL-NK1-CP99994
26.32Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
26.32Single6TP4ACT-4622066TP4-OX1-ACT-462206
26.32Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
26.32Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
26.32Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
26.32Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
26.32Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
26.32Single7XP6Strychnine7XP6-TAS2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
26.32Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
26.32Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
26.32Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
26.32Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
26.32Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
26.32Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
26.32Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
26.32Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
26.32Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
26.32Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
26.32Single8YN2Histamine8YN2-H1-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
26.32Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
26.32Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
26.32Single8YN7Immethridine8YN7-H3-Immethridine-Go/β1/γ2
26.32Single9AS2DMT9AS2-5-HT2A-DMT-chim(NtGi1-Gs-CtGq)/β1/γ2
26.32Single9B9Y7DY9B9Y-CB1-7DY
26.32Single9EPRRetinal9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
26.32Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
26.32Single9IZDCHBA9IZD-HCA1-CHBA-Gi1/β1/γ2
26.32Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
26.32Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
26.32Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
26.32Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
26.09Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
26.09Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
26.09Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
26.09Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
26.09Single7B6WCyclazosin7B6W-α1b-Cyclazosin
26.09Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
26.09Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
26.09Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
26.09Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
26.09Single8JD5JNJ-40411813; ADX881788JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
26.09Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
26.09Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
26.09Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
26.09Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
26.09Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
26.09Single8ZWFJR14a8ZWF-C3aB-JR14a
26.09Single9AS9RS130-1809AS9-5-HT2A-RS130-180
26.09Single9ASARS130-1809ASA-5-HT2A-RS130-180-chim(NtGi1-Gs-CtGq)/β1/γ2
26.09Single9IK9SST analogue9IK9-SST1-SST analogue-Gi1/β1/γ2
26.09Single9UY3Anamorelin9UY3-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
26.09Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
26.09Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
26.09Consensustachykinin_offOrthosteric Ligandnk1_off
25.93Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
25.93Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
25.93Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
25.93Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
25.93Single8IEBA1LYA8IEB-GPR156-A1LYA
25.93Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
25.93Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
25.93Single9IQVMuscarinic toxin 39IQV-Alpha1A-Muscarinic toxin 3
25.93Single9J0FNADH9J0F-P2Y14-NADH-Gi1/β1/γ2
25.93Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
25.93Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
25.93Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
25.81Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
25.81Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
25.81Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
25.81Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
25.81Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
25.81Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
25.81Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
25.81Single8W8WAlpha-MSH8W8W-MC3-α-MSH-Ca-Gs/β1/γ2
25.81Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
25.81Consensusglp_onOrthosteric Ligandglp1_on glp2_on
25.81Consensusglp_on_gpOrthosteric Ligandglp1_on_gp glp2_on_gp
25.81Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
25.71Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
25.71Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
25.00Single3ODUIT1t3ODU-CXCR4-IT1t
25.00Single3PWHZM-2413853PWH-A2A-ZM-241385
25.00Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
25.00Single5TZYMK8666; AP85TZY-FFA1-MK8666; AP8
25.00Single5X33BIIL2605X33-BLT1-BIIL260
25.00Single5ZKQABT-4915ZKQ-PAF-ABT-491
25.00Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
25.00Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
25.00Single6DS0Ly2660976DS0-5-HT2B-Ly266097
25.00Single6ME2Ramelteon6ME2-MT1-Ramelteon
25.00Single6ME9Ramelteon6ME9-MT2-Ramelteon
25.00Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
25.00Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
25.00Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
25.00Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
25.00Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
25.00Single7BR3Elagolix7BR3-GnRH1-Elagolix
25.00Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
25.00Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
25.00Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
25.00Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
25.00Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
25.00Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
25.00Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
25.00Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
25.00Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
25.00Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
25.00Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
25.00Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
25.00Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
25.00Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
25.00Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
25.00Single8GNGIstradefylline8GNG-A2A-Istradefylline
25.00Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
25.00Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
25.00Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
25.00Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
25.00Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
25.00Single8IWESpermidine8IWE-TA9-Spermidine
25.00Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
25.00Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
25.00Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
25.00Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
25.00Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
25.00Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
25.00Single8W8YGamma-MSH8W8Y-MC3-γ-MSH-Ca-Gs/β1/γ2
25.00Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
25.00Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
25.00Single9EBHAdenosine9EBH-A3A-Adenosine-Gi1/β1/γ2
25.00Single9H2XA1IR19H2X-A2A-A1IR1-Na
25.00Single9K6LSA09K6L-TAS2R16-SA0-Gi2/β1/γ2
25.00Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
25.00Single9M1OMorphine-Modulating Neuropeptide B9M1O-NPFF2-Morphine-Modulating Neuropeptide B-Gi1/β1/γ2
25.00Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
25.00Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
25.00Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
25.00Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
25.00Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
25.00Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
25.00Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
25.00Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
25.00Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
25.00Consensusvip-pacap_onOrthosteric Ligandvpac_on pac_on
25.00Consensusvip-pacap_on_gpOrthosteric Ligandvpac_on_gp pac_on_gp
24.24Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
24.24Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
24.14Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
24.14Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
24.14Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
24.14Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
24.14Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
24.14Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
24.14Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
24.14Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
24.14Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
24.00Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
24.00Single5CGDHTL142425CGD-mGlu5-HTL14242
24.00Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
24.00Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
24.00Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
24.00Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
24.00Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
24.00Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
24.00Consensuscck_onOrthosteric Ligandccka_on cckb_on
24.00Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
24.00Consensuschemerin_onOrthosteric Ligandcml1_on
23.81Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
23.81Single5IU7Q274563465IU7-A2A-Q27456346-Na
23.81Single5JTBZM-2413855JTB-A2A-ZM-241385
23.81Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
23.81Single6AQFZM-2413856AQF-A2A-ZM-241385
23.81Single6KUXRS-799486KUX-α2a-RS-79948
23.81Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
23.81Single6MH8ZM-2413856MH8-A2A-ZM-241385
23.81Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
23.81Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
23.81Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
23.81Single7AROLUF58337ARO-A2A-LUF5833-Na
23.81Single7T32ZM-2413857T32-A2A-ZM-241385
23.81Single7VODCariprazine7VOD-5-HT2A-Cariprazine
23.81Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
23.81Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
23.81Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.81Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
23.81Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
23.81Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
23.81Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
23.81Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
23.81Single8Y6YGLPG09748Y6Y-FFA2-GLPG0974
23.81Single9AS3LSD9AS3-5-HT2A-LSD
23.81Single9AS4LSD9AS4-5-HT2A-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
23.81Single9BA0A1AKN9BA0-CB1-A1AKN
23.81Single9JH3CMF-0199JH3-Apelin-CMF-019-Gi1/β1/γ2
23.81Consensusa2_offOrthosteric Liganda2a_off
23.81Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
23.81Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
23.81Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
23.81Consensusgrh_offOrthosteric Ligandgnrh1_off
23.81Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
23.81Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
23.53Single3PXOAll-trans-Retinal3PXO-Rhodopsin-All-trans-Retinal
23.53Single5DYSAll-trans-Retinal5DYS-Rhodopsin-All-trans-Retinal
23.53Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
23.53Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
23.53Single8PWNTheophylline8PWN-A2A-Theophylline
23.53Single9AUCCalcitonin gene-related peptide-19AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
23.53Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
23.33Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
23.33Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
23.33Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
23.33Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
23.33Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
23.33Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
23.33Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
23.33Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.33Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
23.33Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
23.33Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
23.33Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
23.33Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
23.33Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
23.33Consensuspac_onOrthosteric Ligandpac1_on
23.08Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
23.08Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
23.08Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
23.08Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
23.08Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
23.08Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.08Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
23.08Single7XN9L-054,5227XN9-SST2-L-054,522
23.08Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
23.08Single9JF4PD1683689JF4-BB1-PD168368
23.08Single9JH6C20:0 Ceramide9JH6-CysLT2-C20:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
23.08Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
23.08Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
23.08Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
23.08Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
22.86Consensusglp1_on_gpOrthosteric Ligand7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
22.86Consensuspth1_on_gpOrthosteric Ligand6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
22.73Single2Y01Dobutamine2Y01-β1-Dobutamine
22.73Single3EMLZM-2413853EML-A2A-ZM-241385
22.73Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
22.73Single5DSGTiotropium5DSG-M4-Tiotropium
22.73Single5IU8Q274563475IU8-A2A-Q27456347-Na
22.73Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
22.73Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
22.73Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
22.73Single5UENDU1725UEN-A1-DU172
22.73Single5UIGCmpd-15UIG-A2A-Cmpd-1
22.73Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
22.73Single6GPSMK08126GPS-CCR2-MK0812
22.73Single6S0LZM-2413856S0L-A2A-ZM-241385
22.73Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
22.73Single7F83PF-051904577F83-Ghrelin-PF-05190457
22.73Single7PYRPSB-21157PYR-A2A-PSB-2115
22.73Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
22.73Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
22.73Single7YXAONO-54306087YXA-S1P5-ONO-5430608
22.73Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
22.73Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
22.73Single8YN8Proxyfan8YN8-H3-Proxyfan-Go/β1/γ2
22.73Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
22.73Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
22.73Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
22.73Consensuscck_offOrthosteric Ligandccka_off
22.73Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
22.73Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
22.73Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
22.73Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
22.58Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
22.58Single6FJ3PTH6FJ3-PTH1-PTH
22.58Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
22.58Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
22.58Single9BP3Cagrilintide9BP3-CT (AMY1)-Cagrilintide-Gs/β1/γ2; RAMP1
22.58Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
22.58Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
22.58Consensuspac1_onOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
22.58Consensuspac1_on_gpOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
22.58Consensussecretin_onOrthosteric Ligand7D3S-Secretin-Secretin-Gs/β1/γ2
22.50Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
22.22Single3OE8IT1t3OE8-CXCR4-IT1t
22.22Single6OY9All-trans-Retinal6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
22.22Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
22.22Single6TQ9SB-4081246TQ9-OX1-SB-408124
22.22Single7F8XNN90567F8X-CCKA-NN9056
22.22Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
22.22Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
22.22Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
22.22Single8A2OTheophylline8A2O-A2A-Theophylline-Na
22.22Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
22.22Single8KIGSHU91198KIG-MC3-SHU9119-Ca
22.22Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
22.22Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Single8YWFRetatrutide8YWF-GLP-1-Retatrutide-chim(NtGi1-Gs)/β1/γ2
22.22Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
22.22Single9HB3Mambaquaretin-19HB3-V2-Mambaquaretin-1
22.22Single9J0IUDP-Glucuronic acid9J0I-P2Y14-UDP-Glucuronic acid-Gi1/β1/γ2
22.22Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
22.22Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
22.22Consensussensory_onOrthosteric Ligandopsins_on
21.88Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
21.88Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
21.88Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
21.88Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
21.88Single8W8XBeta-MSH8W8X-MC3-β-MSH-Ca-Gs/β1/γ2
21.88Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
21.88Consensussecretin_on_gpOrthosteric Ligand7D3S-Secretin-Secretin-Gs/β1/γ2
21.74Single2Y00Dobutamine2Y00-β1-Dobutamine
21.74Single4NTJAZD12834NTJ-P2Y12-AZD1283
21.74Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
21.74Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
21.74Single5CGCHTL142425CGC-mGlu5-HTL14242
21.74Single5IUAQ274563485IUA-A2A-Q27456348-Na
21.74Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
21.74Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
21.74Single6GPXMK08126GPX-CCR2-MK0812
21.74Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
21.74Single6LUQHaloperidol6LUQ-D2-Haloperidol
21.74Single6S0QZM-2413856S0Q-A2A-ZM-241385
21.74Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
21.74Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
21.74Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
21.74Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
21.74Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
21.74Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
21.74Single8GNEKW-63568GNE-A2A-KW-6356-Na
21.74Single8QOTNanobody-E8QOT-μ-Nanobody-E
21.74Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
21.74Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
21.74Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
21.74Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
21.74Single9B9ZA1AKO9B9Z-CB1-A1AKO
21.74Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
21.74Single9HC04YI9HC0-mGlu5-4YI
21.74Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
21.74Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
21.74Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
21.74Consensusep_offOrthosteric Ligandep4_off
21.74Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
21.74Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
21.62Consensusglucagon_on_gpOrthosteric Ligandglp_on_gp gluc_on_gp secretin_on_gp gip_on_gp
21.43Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
21.43Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
21.43Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
21.43Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
21.43Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
21.43Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
21.43Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
21.43Single9KFIRelaxin-39KFI-RXFP3-Relaxin-3-Gi2/β1/γ2
21.43Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
21.21Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
21.21Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
21.21Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
21.21Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
21.21Consensuspth1_onOrthosteric Ligand6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
21.21Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
21.21Consensusvpac2_on_gpOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
21.05Single6ME5Agomelatine6ME5-MT1-Agomelatine
21.05Single7WC5Psilocin7WC5-5-HT2A-Psilocin
21.05Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.05Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
21.05Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
21.05Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
21.05Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
21.05Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
21.05Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
21.05Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
21.05Single9JHJC18:0 Ceramide9JHJ-FPR2-ALX-C18:0 Ceramide-Gi1/β1/γ2
21.05Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
21.05Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
21.05Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
21.05Consensusgi_sensoryOrthosteric Ligandgi_opsins
21.05Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
21.05Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
20.83Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
20.83Single4BV0Neurotensin4BV0-NTS1-Neurotensin
20.83Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
20.83Single5TZRMK86665TZR-FFA1-MK8666
20.83Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
20.83Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
20.83Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
20.83Single7P2L4YI7P2L-mGlu5-4YI
20.83Single7PX4PSB-21137PX4-A2A-PSB-2113
20.83Single7R0CAVP7R0C-V2-AVP-Arrestin2
20.83Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
20.83Single7T9NDPPC7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
20.83Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.83Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
20.83Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
20.83Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
20.83Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
20.83Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
20.83Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
20.83Single8YNTSNAP-948478YNT-MCH1-SNAP-94847
20.83Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
20.83Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
20.83Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
20.83Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
20.83Consensusneurotensin_onOrthosteric Ligandnts1_on
20.83Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
20.83Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
20.83Consensusrelaxin_onOrthosteric Ligandrxfp4_on
20.83Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
20.69Single3OE0CVX153OE0-CXCR4-CVX15
20.69Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
20.69Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
20.69Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
20.69Single9B5YLong-Acting PTH9B5Y-PTH1-Long-Acting PTH-chim(NtGi1-Gq)/β1/γ2
20.69Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
20.69Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
20.69Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
20.69Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
20.69Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
20.69Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
20.69Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
20.59Consensuscrf1_onOrthosteric Ligand6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF1-Corticoliberin-Gs/β1/γ2
20.59Consensusgip_onOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
20.59Consensusgip_on_gpOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
20.00Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
20.00Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
20.00Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
20.00Single4XEENeurotensin4XEE-NTS1-Neurotensin
20.00Single4XESNeurotensin4XES-NTS1-Neurotensin
20.00Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
20.00Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
20.00Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
20.00Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
20.00Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
20.00Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
20.00Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
20.00Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
20.00Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
20.00Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
20.00Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
20.00Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
20.00Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab
20.00Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
20.00Single8XJNCloprosetnol8XJN-TXA2-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
20.00Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
20.00Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ2
20.00Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
20.00Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
20.00Single9AS7Psilocin9AS7-5-HT2A-Psilocin
20.00Single9BJKNAM9BJK-μ-Naloxone-NAM
20.00Single9BLCCagrilintide backbone (non-acylated)9BLC-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
20.00Single9BUDCagrilintide9BUD-CT-Cagrilintide-Gs/β1/γ2
20.00Single9EBOGLP-1 (ACPC18)9EBO-GLP-1-GLP-1 (ACPC18)-Gs/β1/γ2
20.00Single9GGGI-BOP9GGG-TXA2-I-BOP-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Single9LMPNE52-QQ579LMP-GPR4-NE52-QQ57
20.00Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
20.00Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
20.00Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
20.00Consensusglp1_onOrthosteric Ligand7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
20.00Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
20.00Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
19.44Consensuscrf1_on_gpOrthosteric Ligand6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF1-Corticoliberin-Gs/β1/γ2
19.35Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
19.35Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
19.35Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
19.35Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
19.35Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
19.35Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
19.35Consensusvpac_onOrthosteric Ligandvpac1_on vpac2_on
19.23Single4BUONeurotensin4BUO-NTS1-Neurotensin
19.23Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
19.23Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
19.23Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
19.23Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
19.23Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
19.23Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
19.23Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
19.23Single8JPFNeurotensin8JPF-NTS1-Neurotensin-SBI-553
19.23Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
19.23Single8XJOU466198XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
19.23Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
19.23Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
19.23Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
19.23Consensusfp-alpha_onOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
19.23Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
19.23Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
19.23Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
19.23Consensustp_onOrthosteric Ligand8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
19.23Consensustp_on_gpOrthosteric Ligand8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
19.05Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
19.05Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
19.05Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
19.05Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
19.05Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
19.05Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
19.05Single5U09Taranabant5U09-CB1-Taranabant
19.05Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
19.05Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
19.05Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
19.05Single7F8ULintitript7F8U-CCKA-Lintitript
19.05Single7F8YDevazepide7F8Y-CCKA-Devazepide
19.05Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
19.05Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
19.05Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
19.05Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
19.05Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
19.05Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
19.05Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
19.05Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
19.05Consensusangiotensin_offOrthosteric Ligandat1_off
19.05Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
18.92Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
18.92Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
18.92Consensusglucagon_onOrthosteric Ligandglp_on gluc_on secretin_on gip_on
18.75Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
18.75Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
18.75Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
18.75Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
18.75Single7SK3CXCL127SK3-ACKR3-CXCL12
18.75Single9BLBCagrilintide backbone (non-acylated)9BLB-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
18.75Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
18.75Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
18.75Consensuscrf2_on_gpOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
18.75Consensusvpac_on_gpOrthosteric Ligandvpac1_on_gp vpac2_on_gp
18.52Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
18.52Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
18.52Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
18.52Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
18.52Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
18.52Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
18.42Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
18.42Consensusgluc_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
18.18Single3REYXAC3REY-A2A-XAC
18.18Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
18.18Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
18.18Single5IUBQ274563445IUB-A2A-Q27456344-Na
18.18Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
18.18Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
18.18Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
18.18Single5UVIZM-2413855UVI-A2A-ZM-241385
18.18Single6FFIMMPEP6FFI-mGlu5-MMPEP
18.18Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
18.18Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
18.18Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
18.18Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
18.18Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
18.18Single7UTZDPPC7UTZ-TSH-TR1402-DPPC-Gs/β1/γ2
18.18Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
18.18Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
18.18Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
18.18Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
18.18Single9JFUNE52-QQ579JFU-GPR4-NE52-QQ57
18.18Single9K0KUTP9K0K-P2Y4-UTP-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Single9K0XATP9K0X-P2Y2-ATP-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Gi1/β1/γ2
18.18Single9K20ATP9K20-P2Y2-ATP-chim(NtGi1-Go)/β1/γ2
18.18Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
18.18Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
18.18Consensusglp2_on_gpOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
17.95Consensusgluc_on_gpOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
17.86Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
17.86Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
17.86Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
17.86Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
17.86Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
17.86Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
17.86Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
17.86Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
17.86Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
17.86Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
17.86Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
17.65Single4A4MAll-trans-Retinal4A4M-Rhodopsin-All-trans-Retinal-Gt(CT)
17.65Single5EN0All-trans-Retinal5EN0-Rhodopsin-All-trans-Retinal-Gt(CT)
17.65Single5MZPCaffeine5MZP-A2A-Caffeine-Na
17.65Single8GEJConstrained Epinephrine8GEJ-β2-Constrained Epinephrine-Gs/β1/γ2
17.65Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
17.65Single9BQ3Cagrilintide9BQ3-CT (AMY2)-Cagrilintide-Gs/β1/γ2; RAMP2
17.65Single9BTWCagrilintide9BTW-CT (AMY3)-Cagrilintide-Gs/β1/γ2; RAMP3
17.50Consensusclass-b1_onOrthosteric Ligandglucagon_on vip-pacap_on pth_on crf_on calcitonin_on
17.39Single4QIMANTA XV4QIM-SMO-ANTA XV
17.39Single5T04Neurotensin5T04-NTS1-Neurotensin
17.39Single6D27CAY104716D27-DP2-CAY10471
17.39Single6FFHFenobam6FFH-mGlu5-Fenobam
17.39Single6IIVDaltroban6IIV-TXA2-Daltroban
17.39Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
17.39Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
17.39Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
17.39Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
17.39Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
17.39Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
17.39Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
17.39Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
17.39Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
17.39Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
17.39Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
17.39Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
17.39Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
17.39Single9JGKBalovaptan9JGK-5-HT2B-Balovaptan
17.39Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
17.39Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
17.39Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
17.24Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
17.24Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
17.24Single7XNACYN1548067XNA-SST2-CYN154806
17.24Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
17.24Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
17.24Single9IQRMuscarinic toxin 39IQR-α2a-Muscarinic toxin 3
17.24Single9IQSMuscarinic toxin 39IQS-M4-Muscarinic toxin 3
17.24Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
17.14Single7RBTTirzepatide7RBT-GIP-Tirzepatide-LSN3556672-chim(NtGi1-Gs)/β1/γ2
16.67Single5T1ABMS-6815T1A-CCR2-BMS-681-PubChem 12093170
16.67Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
16.67Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
16.67Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
16.67Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single7WC4Serotonin7WC4-5-HT2A-Serotonin
16.67Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
16.67Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
16.67Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
16.67Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
16.67Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
16.67Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
16.67Consensusadgrg2_onOrthosteric Ligand7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
16.67Consensusadgrg2_on_gpOrthosteric Ligand7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
16.67Consensusclass-b1_class-b2_cons_onOrthosteric Ligandclass-b1_on class-b2_on
16.67Consensusclass-b1_class-b2_cons_on_gpOrthosteric Ligandclass-b1_on_gp class-b2_on_gp
16.67Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
16.67Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
16.67Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
16.22Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
16.22Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
16.22Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
16.13Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
16.13Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
16.13Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
16.13Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
16.00Single5V56TC1145V56-SMO-TC114
16.00Single6OS1TRV0266OS1-AT1-TRV026
16.00Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
16.00Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.00Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
16.00Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
16.00Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
16.00Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
15.91Consensusclass-b1_on_gpOrthosteric Ligandglucagon_on_gp vip-pacap_on_gp pth_on_gp crf_on_gp calcitonin_on_gp
15.79Single3RFMCaffeine3RFM-A2A-Caffeine
15.79Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
15.79Single8Y02Retinal8Y02-OPN1SW-Retinal-Gi1/β1/γ2
15.79Single9EE9Adenosine9EE9-A2A-Adenosine-Gs/β1/γ2
15.62Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
15.62Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
15.62Consensuscalcitonin_onOrthosteric Ligandctlike_on
15.38Single4PY02MeSATP4PY0-P2Y12-2MeSATP
15.38Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
15.38Single6IIURamatroban6IIU-TXA2-Ramatroban
15.38Single6OS2TRV0266OS2-AT1-TRV026
15.38Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
15.38Single6YVRNTS8-136YVR-NTS1-NTS8-13
15.38Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
15.38Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.38Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
15.38Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
15.38Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
15.38Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
15.38Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
15.38Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
15.38Single8Y6WTUG-13758Y6W-FFA2-TUG-1375-4-CMTB-Gi1/β1/γ2
15.38Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
15.38Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
15.38Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
15.38Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
15.38Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
15.15Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
15.15Single9BUBCagrilintide9BUB-CT-Cagrilintide-Gs/β1/γ2
15.15Consensuscalcitonin_on_gpOrthosteric Ligandctlike_on_gp
15.00Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
15.00Single3UZAGTPL92363UZA-A2A-GTPL9236
15.00Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
15.00Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
14.81Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
14.81Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
14.81Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-SBI-553-chim(NtGi1-Go)/β1/γ2
14.81Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
14.81Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
14.81Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
14.81Single8ZPLHF511168ZPL-CXCR4-HF51116
14.81Single9GG5U466199GG5-TXA2-U46619-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.81Single9M1HProstaglandin E29M1H-EP1-Prostaglandin E2-chim(NtGi1-Gs-CtGq)/β1/γ2
14.81Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.81Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29Single6LI0C176LI0-GPR52-C17
14.29Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
14.29Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
14.29Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
14.29Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
14.29Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
14.29Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
14.29Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
14.29Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
14.29Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
14.29Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
14.29Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
14.29Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
14.29Single8XQJJN2418XQJ-Apelin-JN241
14.29Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
14.29Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
14.29Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
14.29Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
14.29Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
14.29Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single9NS9TUG-13759NS9-FFA2-TUG-1375-Compound 187-Gi1/β1/γ2
14.29Consensusctlike_on_gpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
14.29Consensusgq_nucleotideOrthosteric Ligandgq_p2y
14.29Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
14.29Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
13.79Single8XWNCXCL88XWN-CXCR2-CXCL8
13.79Single9BUECagrilintide9BUE-CT-Cagrilintide-Gs/β1/γ2
13.79Consensussomatostatin_offOrthosteric Ligandsst2_off
13.64Single4BWBNeurotensin4BWB-NTS1-Neurotensin
13.64Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
13.64Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
13.64Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
13.64Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.64Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
13.64Single7VVOPTH7VVO-PTH1-PTH-Gs/β1/γ2
13.64Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
13.64Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
13.64Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.64Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
13.64Single8U4PAMD31008U4P-CXCR4-AMD3100-Gi1/β1/γ2
13.64Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
13.64Single8YYWAlpha-ketoglutarate8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
13.64Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
13.33Single7SK5CXCL127SK5-ACKR3-CXCL12
13.33Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
13.33Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
13.04Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
13.04Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
13.04Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
13.04Single7T94LY21196207T94-M2-Acetylcholine-LY2119620-chim(NtGi1-Go)/β1/γ2
13.04Single7VV6C48/807VV6-MRGPRX2-C48/80
13.04Single8K2WAMG4878K2W-CXCR3-AMG487
13.04Single8YRGFospropofol8YRG-MRGPRX4-Fospropofol-chim(NtGi1-Gs-CtGq)/β1/γ2
13.04Single8ZPMAMD0708ZPM-CXCR4-AMD070
13.04Single8ZPNAMD31008ZPN-CXCR4-AMD3100
13.04Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
13.04Single9IXXLTD49IXX-CysLT2-LTD4-chim(NtGi1-Gs-CtGq)/β1/γ2
13.04Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
13.04Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
12.82Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
12.82Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
12.50Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/β1/γ2
12.50Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
12.50Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
12.50Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
12.50Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
12.50Single8ZYYNeurotensin peptide 8-138ZYY-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
12.50Single9IVGGLP-1 (Truncated)9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
12.50Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
12.50Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
12.12Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
12.00Single4JKVTaladegib4JKV-SMO-Taladegib
12.00Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
12.00Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
12.00Single8ZVZBW245C8ZVZ-DP1-BW245C-Gs/β1/γ2
12.00Single8ZYTNeurotensin peptide 8-138ZYT-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
12.00Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
11.76Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
11.54Single5V57TC1145V57-SMO-TC114
11.54Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
11.54Single7F1TMIP-1a7F1T-CCR5-MIP-1a
11.54Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.54Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
11.54Single8ZW0PGD28ZW0-DP1-PGD2-Gs/β1/γ2
11.54Single9CLWTUG-13759CLW-FFA2-TUG-1375-4-CMTB-chim(NtGi1L-Gs-CtGq)/β1/γ2
11.54Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
11.54Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
11.11Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
11.11Single8XQJJN2418XQJ-Apelin-JN241
11.11Single9AU0BW245C9AU0-DP1-BW245C-Gs/β1/γ2
11.11Single9CM3TUG-13759CM3-FFA2-TUG-1375-Compound 187-chim(NtGi1L-Gs-CtGq)/β1/γ2
10.71Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
10.71Single8XVUCXCL28XVU-CXCR2-CXCL2
10.71Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
10.71Single9JH5C16:0 Ceramide9JH5-CysLT2-C16:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
10.53Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
10.34Single6KNMJN241-96KNM-Apelin-JN241-9
10.34Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
10.34Single9CM7TUG-13759CM7-FFA2-TUG-1375-AZ-1729-Gi1/β1/γ2
10.00Single6XBM5LWE6XBM-SMO-5LWE-Gi1/β1/γ2
10.00Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
10.00Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
10.00Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.00Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Gi1/β1/γ2
10.00Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
10.00Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
10.00Consensusp2y_offOrthosteric Ligandp2y1_off
9.52Single4XNWMRS25004XNW-P2Y1-MRS2500
9.52Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
9.52Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
9.52Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/β1/γ2
9.52Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
9.52Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
9.52Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
9.52Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
9.09Single4O9RCyclopamine4O9R-SMO-Cyclopamine
9.09Single5L7IVismodegib5L7I-SMO-Vismodegib
9.09Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
9.09Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.09Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
9.09Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
9.09Single8HSCFab0468HSC-GPR20-Fab046-Gi1/β1/γ2
9.09Single8ZYUNeurotensin peptide 8-138ZYU-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
9.09Single9E7RGB889E7R-PAR2-GB88-chim(NtGi1L-Gs-CtGq)/β1/γ2
9.09Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg4_on
9.09Consensusadgrg_on_gpOrthosteric Ligandadgrg2_on_gp adgrg4_on_gp
8.70Single4K5YCP-3763954K5Y-CRF1-CP-376395
8.70Single4QINSAG1.54QIN-SMO-SAG1.5
8.70Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
8.70Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
8.70Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
8.70Single8T3VDocosa-4,7,10,13,16,19-Hexaenoic acid8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.70Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
8.70Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
8.70Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
8.70Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
8.70Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
8.33Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
8.33Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
8.33Single6ZINSR486926ZIN-NTS1-SR48692
8.33Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
8.33Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Single8IYXYL-3658IYX-GPR34-YL-365
8.33Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
8.00Single4Z9GCP-3763954Z9G-CRF1-CP-376395
8.00Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
8.00Single8GTIBMK-C2058GTI-CRF1-BMK-C205
7.69Single6Z4SSR486926Z4S-NTS1-SR48692
7.69Single8GTGBMK-I1528GTG-CRF1-BMK-I152
7.69Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
7.69Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
7.69Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
7.69Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
7.41Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
7.41Single8GDBPGE28GDB-EP4-PGE2-Gs/β1/γ2
7.41Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
7.41Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Gi1/β1/γ1
7.41Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
7.14Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.14Single8GTMBMK-C2038GTM-CRF1-BMK-C203
7.14Single8XWACXCL18XWA-CXCR2-CXCL1
7.14Single8XWMCXCL68XWM-CXCR2-CXCL6
7.14Single8XWSCXCL58XWS-CXCR2-CXCL5
7.14Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
6.90Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
6.90Single8XWFCXCL38XWF-CXCR2-CXCL3
6.90Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
6.45Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
6.25Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
6.25Single6D35Cholesterol6D35-SMO-Cholesterol
6.25Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
6.25Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
6.25Single6UO8SKF975416UO8-GABAB1, GABAB2-SKF97541-GS39783
6.25Single6UO9SKF975416UO9-GABAB1, GABAB2-SKF97541
6.25Single6W2XPubChem 53110426W2X-GABAB1, GABAB2-PubChem 5311042
6.25Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042
6.25Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042
6.25Single7C7QBaclofen7C7Q-GABAB1, GABAB2-Baclofen-BHFF
6.25Single7C7SCGP546267C7S-GABAB1, GABAB2-CGP54626
6.25Single7CUMCGP546267CUM-GABAB1, GABAB2-CGP54626
6.25Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
6.25Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
6.25Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
6.25Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
6.25Single7DGEQuisqualate7DGE-mGlu1; mGlu1-Quisqualate
6.25Single7DTTCa7DTT-CaS-Ca-Ca
6.25Single7DTTCa7DTT-CaS-Ca-Ca
6.25Single7DTUTryptophan7DTU-CaS-Tryptophan
6.25Single7DTUTryptophan7DTU-CaS-Tryptophan
6.25Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
6.25Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
6.25Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
6.25Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
6.25Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
6.25Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
6.25Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
6.25Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
6.25Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
6.25Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
6.25Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
6.25Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
6.25Single7EB2Baclofen7EB2-GABAB2; GABAB1-Baclofen-rac-BHFF-Gi1/β1/γ2
6.25Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
6.25Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
6.25Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
6.25Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
6.25Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
6.25Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
6.25Single7FIHhCG7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
6.25Single7FIIhCG7FII-LH-hCG-chim(NtGi1-Gs)/β1/γ2
6.25Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
6.25Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
6.25Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
6.25Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
6.25Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
6.25Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
6.25Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
6.25Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
6.25Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
6.25Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
6.25Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
6.25Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
6.25Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
6.25Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
6.25Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
6.25Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
6.25Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
6.25Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
6.25Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
6.25Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
6.25Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
6.25Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
6.25Single7T9NM22 Fab7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
6.25Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
6.25Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
6.25Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
6.25Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
6.25Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
6.25Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
6.25Single7XW6M22 Fab7XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
6.25Single7XW7K1-707XW7-TSH-K1-70
6.25Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
6.25Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
6.25Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
6.25Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
6.25Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
6.25Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
6.25Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
6.25Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
6.25Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
6.25Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
6.25Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
6.25Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
6.25Single8JD0Glutamate8JD0-mGlu2; mGlu3-Glutamate-NAM563
6.25Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
6.25Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
6.25Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
6.25Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
6.25Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
6.25Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
6.25Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
6.25Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
6.25Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
6.25Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
6.25Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
6.25Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
6.25Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
6.25Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
6.25Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
6.25Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
6.25Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
6.25Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
6.25Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
6.25Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
6.25Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
6.25Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
6.25Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
6.25Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
6.25Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
6.25Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
6.25Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
6.25Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
6.25Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
6.25Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
6.25Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
6.25Single8WG9(2S)-2-amino-4-phosphonobutanoic acid8WG9-mGlu4; mGlu2-(2S)-2-amino-4-phosphonobutanoic acid
6.25Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
6.25Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
6.25Single8WGCLY3792688WGC-mGlu4; mGlu2-LY379268
6.25Single8WGDWAG; WA68WGD-mGlu4; mGlu2-WAG; WA6
6.25Single8WGDWAG; WA68WGD-mGlu4; mGlu2-WAG; WA6
6.25Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
6.25Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
6.25Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.25Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.25Single8WVXNorrin8WVX-LGR4-Norrin
6.25Single8WVYNorrin8WVY-LGR4-Norrin
6.25Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
6.25Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
6.25Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
6.25Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
6.25Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
6.25Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
6.25Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
6.25Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
6.25Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
6.25Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
6.25Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
6.25Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
6.25Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
6.25Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
6.25Single8XUMR-spondin-28XUM-LGR4-R-spondin-2
6.25Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
6.25Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
6.25Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
6.25Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
6.25Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
6.25Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
6.25Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
6.25Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
6.25Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
6.25Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
6.25Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
6.25Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
6.25Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
6.25Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
6.25Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
6.25Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
6.25Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
6.25Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
6.25Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
6.25Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
6.25Single9KHHNorrin9KHH-LGR4-Norrin
6.25Single9S37NB219S37-LGR4-NB21
6.25Single9UTBSucralose9UTB-TAS1R2; TAS1R3-Sucralose
5.88Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
5.88Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
5.88Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
5.88Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
5.88Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
5.88Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
5.88Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
5.88Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
5.88Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
5.88Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
5.88Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
5.88Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
5.88Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
5.88Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
5.88Consensusclass-b2_onOrthosteric Ligandadgrg_on adgrf_on adgrl_on adgre_on adgrd_on
5.88Consensusclass-b2_on_gpOrthosteric Ligandadgrg_on_gp adgrf_on_gp adgrl_on_gp adgre_on_gp adgrd_on_gp
5.56Single7KNUCalcitonin gene-related peptide-17KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
5.56Single7T9MCS-17 Antibody7T9M-TSH-CS-17 Antibody
5.56Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
5.26Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
5.26Single7FIGhCG7FIG-LH-hCG-chim(NtGi1L-Gs)/β1/γ2
5.26Single7UTZTR14027UTZ-TSH-TR1402-DPPC-Gs/β1/γ2
5.26Single7XW5TSH7XW5-TSH-TSH-ML109-Gs/β1/γ2
5.26Single7ZI0Cholesterol7ZI0-SMO-SAG-Cholesterol
5.26Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/β1/γ2
5.00Single5L7DCholesterol5L7D-SMO-Cholesterol
5.00Single7T9ITSH7T9I-TSH-TSH-Gs/β1/γ2
5.00Single7V68LY21196207V68-M4-Iperoxo-LY2119620-Gi1/β1/γ2
5.00Single7XKDBeta-Hydroxyandrosterone7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
5.00Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
5.00Single8HS2Fab0468HS2-GPR20-Fab046
5.00Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
5.00Single8I2GGlycoprotein hormones alpha chain8I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
5.00Single8X9S5alpha-DHT8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
4.76Single7Y14Beta-Alanine7Y14-MRGPRD-β-Alanine
4.76Single9IVMLSN33188399IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
4.55Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
4.55Single7Y12Beta-Alanine7Y12-MRGPRD-β-Alanine-Gi1/β1/γ2
4.55Single8J6QCompound 9n8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
4.55Single8JPSCCL78JPS-ACKR1-CCL7
4.35Single8HNNSCH5467388HNN-CXCR3-SCH546738
4.35Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
4.35Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/β1/γ2
4.35Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
4.35Single8YKDDehydroepiandrosterone8YKD-ADGRG2-Dehydroepiandrosterone-chim(NtGi1-Gs)/β1/γ2
4.17Single6C1QNDT95137276C1Q-C5a1-PMX53-NDT9513727
3.85Single8TH3AT118-H Nanobody8TH3-AT1-AT118-H Nanobody
3.85Single9IMATalquetamab9IMA-GPRC5D-Talquetamab
3.70Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
3.70Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
3.70Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
3.12Single8XFTR-spondin-28XFT-LGR4-R-spondin-2-ZNRF3
3.12Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-ZNRF3
2.94Single8WVUR-spondin-18WVU-LGR4-R-spondin-1-RNF43
2.94Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-ZNRF3
2.86Single8XFPR-spondin-28XFP-LGR4-R-spondin-2-ZNRF3
2.63Single8XFSR-spondin-28XFS-LGR4-R-spondin-2-ZNRF3

Consensus Members
Id Members
s1p1_on_gp 7VIE-S1P1-S1P-Gi1/β1/γ2
7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
7VIG-S1P1-CBP-307-Gi1/β1/γ2
7EVY-S1P1-Siponimod-Gi1/β1/γ2
7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
7EW0-S1P1-Ozanimod-Gi1/β1/γ2
7EW7-S1P1-SEW2871-Gi1/β1/γ2
s1p3_on_gp 7EW3-S1P3-S1P-Gi1/β1/γ2
7EW4-S1P3-CYM5541-Gi1/β1/γ2
7EW2-S1P3-Fingolimod-Gi1/β1/γ2
s1p5_on_gp 7EW1-S1P5-Siponimod-Gi1/β1/γ2
Net Summary
Imin 2.43714
Number of Linked Nodes 884
Number of Links 1084
Number of Hubs 168
Number of Links mediated by Hubs 662
Number of Communities 23
Number of Nodes involved in Communities 229
Number of Links involved in Communities 338
Path Summary
Number Of Nodes in MetaPath 161
Number Of Links MetaPath 160
Number of Shortest Paths 924678
Length Of Smallest Path 3
Average Path Length 27.6802
Length of Longest Path 61
Minimum Path Strength 0.2
Average Path Strength 4.99757
Maximum Path Strength 42.6408
Minimum Path Correlation 0.7
Average Path Correlation 0.974952
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2
Average % Of Corr. Nodes 46.6401
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 54.8135
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following differences:
Id1st Network2nd Network
s1p_off_on_gps1p_on_gps1p_off
This network is also present in following consensuses:
IdComponents
lpl_on_gps1p_on_gp
lpa_on_gp



You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download s1p_on_gp.zip



You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.



You can also  read or  download a guide explaining the meaning of all files and numerical data.