Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
1G.HN.36 5.56604454
2G.hns1.01 6.52021404
3G.S1.06 3.933964138
4G.H1.01 3.211335139
5G.S3.03 4.96264608
6G.S3.04 7.796874147
7G.S3.06 8.620624147
8G.H2.06 4.932084159
9G.s4h3.04 3.08967508
10G.H3.01 2.4295509
11G.H3.08 3.21896408
12G.H3.09 3.90333509
13G.H3.13 7.77875406
14G.H3.17 7.75278635
15G.S5.07 2.67569609
16G.hgh4.01 4.66437406
17G.hgh4.05 8.58771406
18G.hgh4.20 4.84292403
19G.hgh4.21 4.55229404
20G.H4.03 2.65458404
21G.H4.08 5.15367573
22G.H4.10 8.55854407
23G.H4.12 4.90333574
24G.H4.15 6.10396408
25G.h4s6.12 4.87417402
26G.S6.05 6.95688475
27G.H5.03 4.201254169
28G.H5.04 2.06479408
29G.H5.17 6.01055175
30b.1x4 2.55667408
31b.l1x3 7.46667409
32b.l1x6 7.90933539
33b.b2x1 5.75433538
34b.b2x5 4.98722607
35b.l3x1 6.54313439
36b.b4x3 4.08407
37b.b4x6 8.48533559
38b.b5x3 4.0981759
39b.b5x5 3.81458405
40b.l5x1 3.44167408
41b.l5x5 7.192509
42b.b6x5 3.05267506
43b.b7x1 5.17125404
44b.l7x4 3.05958409
45b.b8x4 4.47937406
46b.l9x3 6.81854449
47b.l9x6 5.5945548
48b.b10x5 3.71764609
49b.b11x2 3.83104407
50b.l11x2 6.64167449
51b.b12x6 6.07571748
52b.b13x7 6.45417467
53b.l13x3 6.80067569
54b.b15x1 5.54562469
55b.l15x2 5.14167469
56b.b16x4 8.08021466
57b.b16x6 7.1055568
58b.l17x3 6.92847629
59b.l17x6 6.562714159
60b.b18x3 3.83083428
61b.b18x5 4.18667405
62b.l18x1 5.422027116
63b.b19x2 5.4575526
64b.b19x4 4.42917428
65b.l19x2 6.57875429
66b.b20x4 9.4025428
67b.b20x6 6.17896426
68b.b21x1 6.422924197
69b.b21x5 4.51083404
70b.b21x7 5.21567505
71b.b22x5 4.650634117
72b.l22x5 5.919584209
73b.b23x6 5.73583607
74b.l23x1 5.14771436
75b.l24x3 4.08167405
76b.l25x3 8.36625489
77b.l25x6 10.235538
78b.l27x1 7.5769739
79b.l27x2 6.36854489
80b.b28x4 6.73625486
81b.b28x6 7.97146489
82g.h1x8 2.21896407
83g.l1x4 5.067714198
84g.h2x7 2.22542405
85g.h2x11 7.698964116
86g.ctx3 4.95567509
87g.ctx6 3.01625406
88g.ctx14 4.20167409
89g.ctx16 4.335487108
90Lig 9.182444110
91NT.W39 7.67125415
92NT.Y42 6.3355516
93NT.F61 4.283544223
94NT.R64 5.40979404
95NT.W72 5.00583709
96NT.D74 5.618334223
97NT.P77 1.89271404
98NT.P86 4.7745518
99NT.W87 5.31646403
100NT.Y88 7.00267515
101NT.L89 4.43208415
102NT.W91 6.84187414
103NT.Y101 6.127714125
104NT.R102 8.99375498
105NT.F103 5.70417404
106NT.W110 6.51383599
107NT.P119 3.64542496
1081x40 5.80167515
1091x43 5.2455517
1101x47 5.93083717
1111x54 4.08542409
1121x64 6.666464237
1132x46 4.806536189
1142x57 8.19683508
1152x60 7.67486618
116E1.Y220 3.249335253
1173x33 3.29896415
1183x38 4.02833509
1193x44 8.81187418
1203x45 5.638124266
1213x46 12.09235249
1223x50 8.47062409
1233x53 7.78292408
1244x46 5.023507
1254x50 8.695424249
1264x52 3.565424263
1274x53 3.674269
1284x60 7.46792618
1294x68 5.77229406
130E2x51 8.51861618
1315x36 7.45458404
1325x37 10.8558416
1335x40 6.45767506
1346x33 1.18117507
1356x34 1.4625405
1366x52 9.51208418
1376x53 7.93479418
1386x56 3.61319617
1397x34 3.98042415
1407x49 6.92583409
1418x53 9.113754238
1428x56 3.6765507
143H.hahb.04 1.41708400
144H.HB.05 2.7785500
145H.hbhc.04 3.23208600
146H.HC.06 3.16396400
147H.hchd.01 1.53967500
148H.hdhe.01 1.79833500
149H.HE.04 3.94708400
150H.HE.05 2.05317500
151G.hfs2.03 1.93771400
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1b.l2x5 b.l4x2 15.317317.9192NoNo054
2b.l4x2 g.ctx16 15.51223.7825NoYes1048
3b.l4x1 g.ctx16 22.30643.85083NoYes058
4b.b2x5 b.l4x1 22.56063.5YesNo075
5b.b2x5 b.l26x1 41.37878.18833YesNo077
6b.l26x1 b.l26x3 41.55984.94NoNo2177
7b.l26x3 b.l26x5 42.56955.42833NoNo075
8b.l26x5 g.ctx4 42.8073.21417NoNo057
9g.ctx3 g.ctx4 43.28133.6225YesNo097
10g.ctx3 g.ctx6 46.10755.65417YesYes096
11b.l22x5 g.ctx6 47.04223.745YesYes096
12b.l22x5 b.l24x2 49.59366.175YesNo096
13b.h2x5 b.l24x2 50.05453.195NoNo056
14b.h2x1 b.h2x5 50.74413.07167NoNo055
15b.b21x5 b.h2x1 51.43164.9475YesNo045
16b.b21x5 b.b21x7 52.80058.38083YesYes045
17b.b21x7 b.b24x6 60.57349.16333YesNo058
18b.b23x6 b.b24x6 61.56274.66333YesNo078
19b.b23x6 b.l23x2 64.21352.875YesNo078
20b.l21x7 b.l23x2 65.0735.185NoNo058
21b.l21x7 b.l23x1 65.29042.8525NoYes056
22b.l23x1 b.l25x6 54.20739.82667YesYes368
23b.b22x1 b.l25x6 97.79345.17417NoYes088
24b.b22x1 b.b22x2 97.89052.8NoNo088
25b.b22x2 b.b26x3 97.92584.12917NoNo086
26b.b26x3 b.b27x3 98.02352.4575NoNo068
27b.b27x3 b.l25x3 97.96895.59083NoYes089
28b.l25x3 b.l27x2 98.95196.51083YesYes899
29b.l25x4 b.l27x2 1003.99083NoYes059
30I1x49 b.l25x4 49.583613.9717NoNo075
318x53 I1x49 49.59712.4125YesNo087
328x53 I1x50 98.05654.30917YesNo2389
338x50 I1x50 98.88063.10417NoNo099
348x47 8x50 98.7966.65083NoNo099
358x47 8x49 98.54085.91417NoNo099
362x46 8x49 98.45534.36333YesNo099
372x46 G.H5.22 29.74615.06167YesNo094
38G.H5.18 G.H5.22 29.58574.08NoNo034
39G.H5.18 G.H5.19 29.42564.15917NoNo038
40G.H5.15 G.H5.19 41.34532.76333NoNo088
41b.b3x2 b.b4x6 17.53424.26833NoYes059
42b.b2x5 b.b3x2 17.79288.63583YesNo075
438x56 b.l25x4 50.44684.49417YesNo075
448x53 8x56 50.44627.2YesYes087
45G.H3.17 b.l23x1 11.42766.235YesYes356
46G.H3.17 b.l27x1 11.47145.15417YesYes359
47b.l25x6 b.l27x1 65.271115.2425YesYes389
48b.b2x1 b.l27x1 71.40535.305YesYes389
49G.H3.01 G.s4h3.03 23.88144.71667YesNo098
50G.S4.07 G.s4h3.03 24.08161.58333NoNo088
51G.S4.07 G.s5hg.01 24.32382.165NoNo089
52G.S5.07 G.s5hg.01 25.15182.56667YesNo099
53G.S5.07 G.s6h5.01 27.20183.53417YesNo099
54G.S5.05 G.s6h5.01 27.40716.70083NoNo1699
55G.S5.05 G.S6.04 28.42984.9975NoNo099
56G.H5.10 G.S6.04 30.08988.30083NoNo079
57G.H5.10 G.S6.02 30.787611.0142NoNo078
58G.H5.13 G.S6.02 31.4277.85167NoNo088
595x64 G.H5.13 31.57286.79917NoNo1798
605x64 G.H5.16 33.19686.1025NoNo096
61G.H5.12 G.H5.16 33.41592.92083NoNo076
623x60 G.H5.12 34.00735.43333NoNo057
633x60 G.H5.15 34.22533.97833NoNo058
64G.H3.01 G.s1h1.04 23.05084.19667YesNo099
65b.b2x1 b.b6x1 67.91783.99083YesNo089
66b.b6x1 b.l9x6 67.44555.3875NoYes098
67G.H2.07 b.l9x6 25.19273.93833NoYes098
68G.H2.04 G.H2.07 24.83247NoNo099
69G.H2.04 G.H3.08 24.65156.06583NoYes098
70G.H3.08 G.S4.04 24.05664.0575YesNo089
71G.H3.09 G.S4.04 23.8423.48333YesNo099
72G.H3.09 G.H4.15 20.15915.98333YesYes098
73G.H4.10 G.H4.14 18.22077.19083YesNo075
74G.H3.06 G.H4.14 18.71413.09417NoNo065
75G.H3.06 G.H4.15 18.96057.3075NoYes068
76G.H4.10 G.hgh4.08 11.84169.6275YesNo076
773x57 G.H5.19 13.143413.3917NoNo088
786x45 6x49 13.76384.96NoNo099
795x50 6x49 14.14435.95NoNo099
803x48 5x50 14.52473.89083NoNo089
813x48 5x46 15.66433.545NoNo087
823x45 5x46 16.04374.44583YesNo067
833x45 4x53 17.5325.67583YesYes2669
843x38 4x53 20.20213.59083YesYes099
853x38 4x50 22.45865.30417YesYes099
863x46 4x50 23.201722.9617YesYes2499
872x56 3x46 18.04596.58833NoYes099
882x56 3x43 18.20546.58083NoNo099
892x57 3x43 54.697316.5133YesNo089
902x53 2x57 56.125.8875NoYes098
912x53 3x50 57.91947.06917NoYes099
922x50 3x50 65.883111.3875NoYes099
932x46 2x50 66.31834.325YesNo099
943x46 3x49 17.62586.74417YesNo098
953x49 4x46 17.77553.89333NoYes087
963x53 4x46 20.11957.365YesYes087
972x49 3x53 19.50125.2375NoYes088
982x49 3x50 19.66156.14917NoYes089
99b.l11x1 b.l9x6 42.75366.3975NoYes498
100b.b11x6 b.l11x1 42.89552.62833NoNo499
101b.b11x6 b.l9x3 41.274611.5067NoYes499
102b.b12x6 b.l9x3 40.73964.32YesYes489
103b.b11x2 b.b12x6 39.25862.24917YesYes078
104b.b10x3 b.b11x2 32.77723.13667NoYes087
105b.b10x3 b.b6x2 32.54363.8025NoNo088
106b.b10x2 b.b6x2 32.31382.1125NoNo068
107b.b10x2 b.b14x3 32.07763.57083NoNo065
108b.b11x3 b.b14x3 31.90852.73167NoNo055
109b.b11x3 b.b15x1 31.67343.16583NoYes059
110b.b15x1 b.l16x1 22.11541.6375YesNo094
111b.l16x1 b.l16x2 21.87131.635NoNo049
112b.l14x5 b.l16x2 21.6274.79833NoNo059
113b.l14x3 b.l14x5 21.38258.04083NoNo055
114b.l14x1 b.l14x3 21.13781.93NoNo045
115b.b18x5 b.l14x1 20.89283.81417YesNo054
116b.b15x2 b.b18x5 19.91036.99333NoYes065
117b.b15x2 b.b19x2 16.08975.245NoYes266
118b.b17x7 b.b19x2 14.19658.6625NoYes286
119b.b17x5 b.b17x7 14.10047.0275NoNo078
120b.b17x5 b.b21x1 11.83016.74417NoYes077
121b.1x19 b.b21x1 10.30628.33667NoYes067
122b.l2x3 b.l2x5 10.97354.1675NoNo085
123b.b3x1 b.l2x3 10.70684.52417NoNo058
124b.b3x1 b.b6x5 10.43982.63583NoYes056
1252x60 3x43 51.214610.4467YesNo089
1262x60 Lig 47.71474.36083YesYes180
127Lig NT.Y88 19.63354.71667YesYes105
128NT.P86 NT.Y88 16.44986.8375YesYes185
129NT.P86 NT.Y69 14.69923.70917YesNo086
130NT.L123 NT.Y69 14.53373.42NoNo056
131NT.L123 NT.R121 14.12997.08583NoNo056
132NT.D67 NT.R121 13.89133.87083NoNo096
133NT.D67 NT.W72 13.65265.77083NoYes099
134NT.R102 NT.W72 12.288916.4092YesYes089
1355x54 6x45 11.47556.7NoNo099
136G.s1h1.04 H.hehf.07 22.64993.23333NoNo090
137H.HF.03 H.hehf.07 22.44942.69917NoNo000
138H.HF.03 H.hehf.04 18.64112.10833NoNo000
139H.HE.12 H.hehf.04 16.03532.21583NoNo000
140H.HC.04 H.HE.12 15.83491.00833NoNo000
141H.HC.03 H.HC.04 14.83272.9225NoNo000
142H.HC.03 H.hbhc.04 14.63224.01833NoYes000
143H.HB.12 H.hbhc.04 11.42522.73083NoYes000
144H.HB.08 H.HB.12 11.02433.04917NoNo000
145H.HB.08 H.HC.06 10.4233.53917NoYes000
1463x53 3x57 12.795812.6008YesNo088
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
3x37Lig4.535831NoYes6010
3x40Lig9.310831NoYes8010
5x37Lig6.575831YesYes5010
7x38Lig7.523330NoYes7010
7x41Lig4.778331NoYes6010
1x47Lig4.094171YesYes7010
2x60Lig4.360831YesYes6010
3x36Lig3.280831NoYes6010
7x42Lig7.31251NoYes9010
E2.N300Lig4.383331NoYes0010
E3.D372Lig4.696671NoYes0010
7x34Lig8.4851YesYes5010
1x36Lig9.76750NoYes5010
1x39Lig4.691NoYes7010
1x40Lig3.731YesYes7010
1x43Lig5.91751YesYes7010
2x67Lig9.738331NoYes3010
2x71Lig6.3650NoYes0010
3x33Lig4.323331YesYes7010
E2x52Lig8.528331NoYes5010
E2.R299Lig15.40331NoYes0010
2x75Lig14.021NoYes0010
1x33Lig6.561671NoYes3010
LigNT.L324.620831YesNo0001
LigNT.P903.231YesNo0001
LigNT.W3911.29581YesYes0001
E1.W214Lig22.03331NoYes0010
LigNT.W915.6551YesYes0001
LigNT.Y884.716671YesYes0001
LigNT.E685.810831YesNo0001
NT.E34NT.S314.910NoNo0021
NT.Q37NT.W339.6750NoNo0021
NT.P90NT.T354.516671NoNo0012
NT.R43NT.W397.831670NoYes0021
NT.W39NT.Y889.323331YesYes0011
NT.P86NT.Y426.141671YesYes0022
NT.Y42NT.Y889.349171YesYes0021
NT.P86NT.Y886.83751YesYes0021
NT.L89NT.Y884.786671YesYes0021
NT.P90NT.W916.081NoYes0011
NT.E128NT.W919.17750NoYes0021
1x357x357.026670NoNo6621
1x397x394.770831NoNo7512
1x401x436.28751YesYes7711
1x401x446.451YesNo7612
1x402x6810.72581YesNo7312
1x431x473.39251YesYes7711
1x432x686.03751YesNo7312
1x437x424.59251YesNo7911
1x472x607.201671YesYes7611
1x472x614.22751YesNo7712
1x472x649.881671YesNo7712
1x477x4610.91581YesNo7912
2x603x4010.89581YesNo6811
2x603x4310.44671YesNo6912
2x603x448.83251YesYes6812
2x607x454.311671YesNo6912
2x633x363.706670NoNo4621
2x672x686.91251NoNo3312
2x673x367.081NoNo3611
2x742x754.988330NoNo0021
2x74E1.Q2214.759170NoNo0022
E1.Q211E1.W2145.840830NoNo0021
3x33E2x525.619171YesNo7511
3x374x609.49251NoYes6812
3x375x396.746671NoNo6312
4x605x3913.01581YesNo8322
5x37E2.N30016.47921YesNo5011
5x375x394.20751YesNo5312
5x375x4016.16081YesYes5412
6x567x374.756671YesNo0822
6x567x414.95751YesNo0621
7x34E3.D3724.268331YesNo5011
7x377x416.0751NoNo8621
LigNT.S313.310831YesNo0001
E1.Q221NT.W333.468330NoNo0021
LigNT.W337.001671YesNo0001
LigNT.V364.80251YesNo0001
NT.L89NT.P864.5151YesYes0022
NT.L89NT.W916.4551YesYes0021
E1.H212E1.Q2103.400830NoNo0021
7x35Lig4.7451NoYes6010
2x72Lig3.338330NoYes0010
2x75NT.L323.419171NoNo0011
NT.E68NT.F662.81751NoNo0012
E1.Q210Lig2.571671NoYes0010
E1.L218NT.V362.2350NoNo0021
E1.D215NT.W392.234170NoYes0021
7x34E3.R3762.04251YesNo5012
E2.G295E2.R29920NoNo0021
LigNT.V301.98251YesNo0001
1x401x411.8151YesNo7512
1x472x651.80251YesNo7412
1x33NT.S1361.676671NoNo3012
3x323x331.63750NoYes6721
2x703x331.615830NoYes0721
LigNT.P1371.455831YesNo0001
2x76E1.A2091.4251NoNo0012
7x317x341.125830NoYes4521
2x76Lig1.061671NoYes0010
NT.P137NT.T291.021NoNo0012

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
96.30Consensusglp1_onOrthosteric Ligand7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
75.00Consensusvpac1_on_gpOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
71.43Consensusvpac1_onOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
68.97Consensuspac1_onOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
68.97Consensuspac1_on_gpOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
66.67Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
66.67Consensusglp2_on_gpOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
63.33Consensussecretin_onOrthosteric Ligand7D3S-Secretin-Secretin-Gs/β1/γ2
61.29Consensussecretin_on_gpOrthosteric Ligand7D3S-Secretin-Secretin-Gs/β1/γ2
57.58Consensusgip_onOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
57.58Consensusgip_on_gpOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
54.55Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
54.55Consensusvpac2_on_gpOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
54.29Consensuspth1_on_gpOrthosteric Ligand6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
52.78Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
52.63Consensuspth2_on_gpOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
51.35Consensusgluc_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
50.00Consensusgluc_on_gpOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
45.71Consensuspth1_onOrthosteric Ligand6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
38.89Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
38.46Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
38.24Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ2
37.84Consensusctlike_on_gpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
37.14Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
37.14Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
36.84Single7RBTTirzepatide7RBT-GIP-Tirzepatide-LSN3556672-chim(NtGi1-Gs)/β1/γ2
36.11Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
36.11Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
36.11Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
36.11Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
36.11Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
35.90Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
35.29Single5WF5UK-4320975WF5-A2A-UK-432097
35.14Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
35.14Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
35.14Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
34.29Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
34.29Single9EBOGLP-1 (ACPC18)9EBO-GLP-1-GLP-1 (ACPC18)-Gs/β1/γ2
34.29Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
34.29Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
34.29Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
34.21Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
34.21Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
34.21Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
34.21Single9BYOExendin-39BYO-GLP-1-Exendin-3-Gs/β1/γ2
34.21Consensusvip-pacap_onOrthosteric Ligandvpac_on pac_on
34.21Consensusvip-pacap_on_gpOrthosteric Ligandvpac_on_gp pac_on_gp
33.33Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
33.33Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
33.33Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
32.50Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
32.43Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
32.43Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
32.43Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
32.43Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
32.43Single9BLBCagrilintide backbone (non-acylated)9BLB-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
32.43Single9BLWCagrilintide backbone (non-acylated)9BLW-CT (AMY1)-Cagrilintide backbone (non-acylated)-Gs/β1/γ2; RAMP1
32.43Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
32.43Consensuspac_on_gpOrthosteric Ligandpac1_on_gp
32.43Consensusvpac_on_gpOrthosteric Ligandvpac1_on_gp vpac2_on_gp
32.35Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
32.35Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
32.26Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
31.71Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
31.71Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
31.58Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
31.58Single9BUCCagrilintide9BUC-CT-Cagrilintide-Gs/β1/γ2
31.58Consensusglp_onOrthosteric Ligandglp1_on glp2_on
31.58Consensusglp_on_gpOrthosteric Ligandglp1_on_gp glp2_on_gp
31.43Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
31.43Consensusangiotensin_onOrthosteric Ligandat1_on
31.43Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
31.11Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
30.95Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
30.95Consensusglucagon_onOrthosteric Ligandglp_on gluc_on secretin_on gip_on
30.77Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
30.56Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
30.56Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
30.56Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
30.56Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
30.56Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
30.43Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
30.30Single7SK9CCX6627SK9-ACKR3-CCX662
30.30Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
30.23Consensusglucagon_on_gpOrthosteric Ligandglp_on_gp gluc_on_gp secretin_on_gp gip_on_gp
30.00Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
30.00Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
30.00Consensuscrf1_onOrthosteric Ligand6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF1-Corticoliberin-Gs/β1/γ2
29.73Consensuspac_onOrthosteric Ligandpac1_on
29.73Consensusvpac_onOrthosteric Ligandvpac1_on vpac2_on
29.41Consensuslpl_onOrthosteric Ligands1p_on lpa_on
29.41Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
29.27Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
29.27Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
29.17Consensusclass-b1_on_gpOrthosteric Ligandglucagon_on_gp vip-pacap_on_gp pth_on_gp crf_on_gp calcitonin_on_gp
29.03Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
28.95Single6FJ3PTH6FJ3-PTH1-PTH
28.95Consensuscrf2_on_gpOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
28.57Single3QAKUK-4320973QAK-A2A-UK-432097
28.57Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
28.57Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
28.57Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
28.57Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
28.57Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
28.57Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
28.57Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
28.57Consensuscrf1_on_gpOrthosteric Ligand6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF1-Corticoliberin-Gs/β1/γ2
28.57Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
28.21Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
28.21Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
28.21Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
28.21Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
28.21Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
28.12Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
28.12Single9EBIPiclidenoson9EBI-A3A-Piclidenoson-chim(NtGi1L-Gs-CtGi1)/β1/γ2
27.91Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
27.91Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
27.91Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
27.78Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
27.78Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
27.50Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
27.50Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
27.50Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
27.50Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
27.27Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
27.27Single7EZCUKA7EZC-A2A-UKA
27.27Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
27.27Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
27.27Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
27.27Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
27.27Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
27.03Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
27.03Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
27.03Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
27.03Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
27.03Single9BLCCagrilintide backbone (non-acylated)9BLC-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
27.03Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
27.03Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
27.03Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
26.67Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
26.67Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
26.67Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
26.67Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
26.67Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
26.47Single4UG2CGS216804UG2-A2A-CGS21680
26.47Single5WF6UK-4320975WF6-A2A-UK-432097
26.32Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
26.32Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
26.32Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
26.32Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
26.32Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
26.32Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
26.32Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
26.32Consensuscalcitonin_onOrthosteric Ligandctlike_on
26.32Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
26.32Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
26.19Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
26.09Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
26.09Consensusclass-b1_onOrthosteric Ligandglucagon_on vip-pacap_on pth_on crf_on calcitonin_on
25.81Single7LD3Adenosine7LD3-A1-Adenosine-MIPS521-Gi2/β1/γ2
25.81Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
25.81Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
25.81Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
25.81Single9CIBFCH-22964139CIB-HCA2-FCH-2296413
25.81Consensusa3_on_gpOrthosteric Liganda3a_on_gp
25.81Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
25.81Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
25.71Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
25.71Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
25.71Single8WDTphotoNECA8WDT-A2A-photoNECA
25.71Single8YWFRetatrutide8YWF-GLP-1-Retatrutide-chim(NtGi1-Gs)/β1/γ2
25.71Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
25.71Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
25.64Single4XT3Fractalkine4XT3-US28-Fractalkine
25.64Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
25.64Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
25.64Single9BP3Cagrilintide9BP3-CT (AMY1)-Cagrilintide-Gs/β1/γ2; RAMP1
25.64Single9KFKRelaxin-39KFK-RXFP4-Relaxin-3-Gi2/β1/γ2
25.64Consensuscalcitonin_on_gpOrthosteric Ligandctlike_on_gp
25.64Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
25.64Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
25.64Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
25.58Consensuscrf_on_gpOrthosteric Ligandcrf2_on_gp crf1_on_gp
25.58Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
25.00Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
25.00Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
25.00Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
25.00Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
25.00Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
25.00Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
25.00Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
25.00Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
25.00Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
25.00Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
25.00Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
25.00Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
25.00Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
25.00Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
25.00Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
25.00Single9IQSMuscarinic toxin 39IQS-M4-Muscarinic toxin 3
25.00Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
25.00Consensusclass-a_class-b1_cons_on_gpOrthosteric Ligandclass-a_on_gp class-b1_on_gp
25.00Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
25.00Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
25.00Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
25.00Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
25.00Consensuspth_on_gpOrthosteric Ligandpth1_on_gp pth2_on_gp
25.00Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
25.00Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
25.00Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
25.00Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
24.39Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
24.39Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
24.39Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
24.39Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
24.39Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
24.39Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
24.39Single9BQ3Cagrilintide9BQ3-CT (AMY2)-Cagrilintide-Gs/β1/γ2; RAMP2
24.39Single9BTWCagrilintide9BTW-CT (AMY3)-Cagrilintide-Gs/β1/γ2; RAMP3
24.39Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
24.39Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
24.39Consensusbradykinin_onOrthosteric Ligandbk2_on
24.39Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
24.39Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
24.32Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
24.32Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
24.32Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
24.32Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
24.32Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
24.32Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
24.32Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
24.32Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
24.32Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
24.32Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
24.32Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
24.32Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
24.24Single6A93Risperidone6A93-5-HT2A-Risperidone
24.24Single6OS2TRV0266OS2-AT1-TRV026
24.24Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
24.24Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
24.24Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
24.24Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
24.24Consensuslpl_offOrthosteric Ligands1p_off lpa_off
24.14Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
24.14Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
24.14Single9EBHAdenosine9EBH-A3A-Adenosine-Gi1/β1/γ2
23.91Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
23.91Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
23.81Single5GLHEndothelin-15GLH-ETB-Endothelin-1
23.81Single6IGKEndothelin-36IGK-ETB-Endothelin-3
23.81Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
23.81Consensusclass-a_class-b1_cons_onOrthosteric Ligandclass-a_on class-b1_on
23.68Single6JODAngiotensin II6JOD-AT2-Angiotensin II
23.68Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
23.68Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
23.68Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
23.68Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
23.68Single8ZBISomatostatin-148ZBI-SST3-Somatostatin-14-Gi1/β1/γ2
23.68Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
23.68Single9BUDCagrilintide9BUD-CT-Cagrilintide-Gs/β1/γ2
23.68Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
23.68Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
23.53Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
23.53Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
23.53Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
23.53Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
23.53Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
23.53Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
23.33Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
23.33Single7T32ZM-2413857T32-A2A-ZM-241385
23.33Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
23.33Single8K5CAcipimox8K5C-HCA2-Acipimox
23.33Single9K0KUTP9K0K-P2Y4-UTP-chim(NtGi1-Gs-CtGq)/β1/γ2
23.33Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
23.33Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
23.26Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
23.26Single9AUCCalcitonin gene-related peptide-19AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
23.08Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
23.08Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
23.08Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
23.08Single8ZRTET-18ZRT-ETB-ET-1
23.08Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
23.08Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
23.08Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
23.08Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
23.08Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
23.08Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
23.08Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
23.08Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
22.86Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
22.86Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
22.86Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
22.86Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
22.86Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
22.86Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
22.86Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
22.86Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
22.86Single9IZASCH9002719IZA-HCA2-SCH900271-Gi1/β1/γ2
22.86Single9M0RNeuropeptide VF9M0R-NPFF1-Neuropeptide VF-Gi1/β1/γ2
22.86Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
22.86Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
22.86Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
22.86Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
22.73Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
22.58Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
22.58Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
22.58Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
22.58Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
22.58Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
22.58Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
22.58Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
22.58Single9IZCMK19039IZC-HCA2-MK1903-Gi1/β1/γ2
22.58Consensusa3_onOrthosteric Liganda3a_on
22.58Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
22.58Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
22.58Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
22.58Consensusblt_onOrthosteric Ligandblt1_on
22.58Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
22.58Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
22.58Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
22.58Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
22.58Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
22.58Consensushca_on_gpOrthosteric Ligandhca2_on_gp
22.58Consensusleukotriene_onOrthosteric Ligandblt_on
22.58Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
22.50Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
22.50Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
22.50Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
22.50Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
22.50Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
22.50Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
22.50Single9BUBCagrilintide9BUB-CT-Cagrilintide-Gs/β1/γ2
22.50Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
22.50Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
22.50Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
22.22Single4IARErgotamine4IAR-5-HT1B-Ergotamine
22.22Single4XT1Fractalkine4XT1-US28-Fractalkine
22.22Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
22.22Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
22.22Single7QA8Peptide7QA8-STE2-Peptide
22.22Single7QA8Peptide7QA8-STE2-Peptide
22.22Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
22.22Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
22.22Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
22.22Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
22.22Single8U4OCXCL128U4O-CXCR4-CXCL12-Gi1/β1/γ2
22.22Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
22.22Single9BUYLM1899BUY-β2-LM189-Gi1/β1/γ2
22.22Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
22.22Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
22.22Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
22.22Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
22.22Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
22.22Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
21.95Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
21.95Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
21.95Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
21.95Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
21.95Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
21.95Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
21.95Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
21.95Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
21.95Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
21.95Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
21.88Single5C1MBU725C1M-μ-BU72
21.88Single5N2RPSB-365N2R-A2A-PSB-36-Na
21.88Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
21.88Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
21.88Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
21.88Single7C61Ergotamine7C61-5-HT1B-Ergotamine
21.88Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
21.88Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.88Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
21.88Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
21.88Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
21.88Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
21.88Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
21.88Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
21.88Single9EE8Adenosine9EE8-A2A-Adenosine-Gs/β1/γ2
21.88Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
21.88Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
21.88Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
21.88Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
21.88Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
21.88Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
21.74Consensuspth_onOrthosteric Ligandpth1_on pth2_on
21.62Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
21.62Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
21.62Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
21.62Single9E82SDF-1-beta9E82-ACKR3-SDF-1-β-Arrestin2
21.62Single9IQVMuscarinic toxin 39IQV-Alpha1A-Muscarinic toxin 3
21.62Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
21.43Single6IGLIRL16206IGL-ETB-IRL1620
21.43Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
21.43Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
21.43Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
21.43Consensusendothelin_onOrthosteric Ligandetb_on eta_on
21.21Single2YDVNECA2YDV-A2A-NECA
21.21Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
21.21Single4UHRCGS216804UHR-A2A-CGS21680
21.21Single5G53NECA5G53-A2A-NECA-Gs
21.21Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
21.21Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
21.21Single6OS1TRV0266OS1-AT1-TRV026
21.21Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
21.21Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
21.21Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
21.21Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
21.21Single7TUYGSK682753A7TUY-GPR183-GSK682753A
21.21Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
21.21Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
21.21Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
21.21Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
21.21Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
21.21Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
21.21Single8E0GBU728E0G-μ-BU72
21.21Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
21.21Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
21.21Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
21.21Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
21.21Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
21.21Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
21.21Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
21.21Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
21.21Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
21.21Single9JMCDS-3801b9JMC-Motilin-DS-3801b-chim(Gs-CtGq)/β1/γ2
21.21Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
21.21Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
21.21Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
21.21Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
21.21Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
21.21Consensuslpa_onOrthosteric Ligandlpa1_on
21.21Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
21.21Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
21.21Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
21.21Consensusrelaxin_onOrthosteric Ligandrxfp4_on
21.21Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
21.21Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
21.21Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
21.15Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
21.05Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
21.05Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
21.05Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
21.05Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
21.05Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
21.05Single9U4WGonadoliberin-19U4W-GnRH1-Gonadoliberin-1-chim(NtGi1L-Gs-CtGq)/β1/γ2
21.05Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
21.05Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
21.05Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
21.05Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
21.05Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
21.05Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
20.93Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
20.93Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
20.93Consensusbombesin_onOrthosteric Ligandbb2_on
20.93Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
20.93Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
20.93Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
20.93Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
20.93Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
20.93Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
20.69Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
20.69Single8K5BNiacin8K5B-HCA2-Niacin
20.69Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
20.59Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
20.59Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
20.59Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
20.59Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
20.59Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
20.59Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
20.59Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
20.59Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
20.59Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
20.59Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
20.59Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
20.59Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
20.59Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
20.59Single8JJ8Formoterol8JJ8-β2-Formoterol
20.59Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
20.59Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
20.59Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
20.59Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
20.59Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
20.59Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
20.59Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
20.59Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
20.59Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
20.59Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
20.59Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
20.59Consensuslpa_offOrthosteric Ligandlpa1_off
20.59Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
20.59Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
20.59Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
20.59Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
20.51Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
20.51Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
20.51Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
20.51Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
20.51Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
20.51Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
20.51Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
20.51Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
20.51Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
20.51Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
20.51Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
20.51Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
20.51Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
20.51Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
20.51Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
20.51Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
20.51Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
20.51Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
20.51Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
20.51Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
20.51Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
20.51Consensusvasop-oxy_onOrthosteric Ligandv2_on
20.51Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
20.45Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
20.45Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
20.45Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
20.00Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
20.00Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
20.00Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
20.00Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
20.00Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
20.00Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
20.00Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
20.00Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
20.00Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
20.00Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
20.00Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
20.00Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
20.00Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
20.00Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
20.00Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
20.00Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
20.00Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
20.00Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
20.00Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
20.00Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
20.00Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
20.00Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
20.00Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
20.00Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
20.00Single8IWESpermidine8IWE-TA9-Spermidine
20.00Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
20.00Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
20.00Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
20.00Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
20.00Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
20.00Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
20.00Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
20.00Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
20.00Single9C0KExendin-49C0K-GLP-1-Exendin-4-Gs/β1/γ2
20.00Single9DYEBuspirone9DYE-5-HT1A-Buspirone-Go/β1/γ2
20.00Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
20.00Single9JFYhNPSF9JFY-NPFF2-hNPSF-Gi1/β1/γ2
20.00Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
20.00Single9M1HProstaglandin E29M1H-EP1-Prostaglandin E2-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single9M54Neuropeptide VF9M54-NPFF2-Neuropeptide VF-Gi1/β1/γ2
20.00Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
20.00Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
20.00Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
20.00Consensusangiotensin_offOrthosteric Ligandat1_off
20.00Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
20.00Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
20.00Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
20.00Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
20.00Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
20.00Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Consensusprostanoid_offOrthosteric Ligandep_off dp_off
20.00Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
20.00Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
20.00Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
19.57Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
19.51Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
19.51Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
19.44Single3NY9ICI118-5513NY9-β2-ICI118-551
19.44Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
19.44Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
19.44Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
19.44Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
19.44Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
19.44Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
19.44Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
19.44Single8QJ2pN1628QJ2-MC4-pN162-Gs
19.44Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
19.44Single8X5YAstemizole8X5Y-H1-Astemizole
19.44Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
19.44Single9IPVJR14a9IPV-C3aB-JR14a-Gi1/β1/γ2
19.44Single9MD1Buspirone9MD1-5-HT1A-Buspirone-Gz/β1/γ2
19.44Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
19.44Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
19.44Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
19.35Single2YDOAdenosine2YDO-A2A-Adenosine
19.35Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
19.35Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
19.35Single5IUBQ274563445IUB-A2A-Q27456344-Na
19.35Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
19.35Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
19.35Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
19.35Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
19.35Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
19.35Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
19.35Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
19.35Single7F61PF-036547467F61-H3-PF-03654746
19.35Single7T94LY21196207T94-M2-Acetylcholine-LY2119620-chim(NtGi1-Go)/β1/γ2
19.35Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
19.35Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
19.35Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
19.35Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
19.35Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
19.35Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
19.35Single8K2WAMG4878K2W-CXCR3-AMG487
19.35Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
19.35Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.35Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
19.35Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
19.35Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
19.35Single8ZPMAMD0708ZPM-CXCR4-AMD070
19.35Single9JFUNE52-QQ579JFU-GPR4-NE52-QQ57
19.35Single9JH3CMF-0199JH3-Apelin-CMF-019-Gi1/β1/γ2
19.35Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
19.35Single9K0XATP9K0X-P2Y2-ATP-chim(NtGi1-Gs-CtGq)/β1/γ2
19.35Single9K20ATP9K20-P2Y2-ATP-chim(NtGi1-Go)/β1/γ2
19.35Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
19.35Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
19.35Consensushca_onOrthosteric Ligandhca2_on
19.05Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
19.05Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
19.05Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
19.05Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
18.92Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
18.92Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
18.92Single7F8XNN90567F8X-CCKA-NN9056
18.92Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
18.92Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
18.92Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
18.92Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
18.92Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
18.92Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
18.92Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
18.92Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
18.92Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
18.92Single9HB3Mambaquaretin-19HB3-V2-Mambaquaretin-1
18.92Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
18.92Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
18.92Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
18.92Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
18.75Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
18.75Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
18.75Single4YAYZD-71554YAY-AT1-ZD-7155
18.75Single5IU8Q274563475IU8-A2A-Q27456347-Na
18.75Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
18.75Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
18.75Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
18.75Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
18.75Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
18.75Single6PS1Timolol6PS1-β2-Timolol
18.75Single6XBM5LWE6XBM-SMO-5LWE-Gi1/β1/γ2
18.75Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
18.75Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
18.75Single7PYRPSB-21157PYR-A2A-PSB-2115
18.75Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
18.75Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
18.75Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
18.75Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
18.75Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
18.75Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
18.75Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
18.75Single8K5DGSK2560738K5D-HCA2-GSK256073
18.75Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
18.75Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
18.75Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
18.75Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
18.75Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
18.75Single9IVGGLP-1 (Truncated)9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
18.75Single9JEAAtropine9JEA-M1-Atropine
18.75Single9KFJPubChem 1383196749KFJ-RXFP3-PubChem 138319674-Gi2/β1/γ2
18.75Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
18.75Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
18.75Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
18.75Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
18.75Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
18.75Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
18.75Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
18.60Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
18.60Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
18.60Single8IY6Endothelin-18IY6-ETB-Endothelin-1
18.60Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
18.42Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
18.42Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
18.42Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
18.42Single7SK5CXCL127SK5-ACKR3-CXCL12
18.42Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
18.42Single7XNACYN1548067XNA-SST2-CYN154806
18.42Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
18.42Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
18.42Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
18.42Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
18.42Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
18.42Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
18.42Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
18.42Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
18.42Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
18.42Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
18.42Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
18.42Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
18.18Single5IUAQ274563485IUA-A2A-Q27456348-Na
18.18Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
18.18Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
18.18Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
18.18Single6D26Fevipiprant6D26-DP2-Fevipiprant
18.18Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
18.18Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
18.18Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
18.18Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
18.18Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
18.18Single6S0QZM-2413856S0Q-A2A-ZM-241385
18.18Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
18.18Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
18.18Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
18.18Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
18.18Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
18.18Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
18.18Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
18.18Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
18.18Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.18Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
18.18Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
18.18Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
18.18Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
18.18Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
18.18Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
18.18Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
18.18Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
18.18Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
18.18Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
18.18Single8S4DCMF-0198S4D-Apelin-CMF-019
18.18Single8TF5Oleic acid8TF5-GPR6-Oleic acid
18.18Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
18.18Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
18.18Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
18.18Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
18.18Single8WGBVU01550418WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
18.18Single8XYKVUF106618XYK-CXCR3-VUF10661-Go/β1/γ2
18.18Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
18.18Single8ZYTNeurotensin peptide 8-138ZYT-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
18.18Single9B9ZA1AKO9B9Z-CB1-A1AKO
18.18Single9DYDAsenapine9DYD-5-HT1A-Asenapine-Go/β1/γ2
18.18Single9DYFAsenapine9DYF-5-HT1A-Asenapine-Gi1/β1/γ2
18.18Single9EHSLUF76029EHS-A3A-LUF7602
18.18Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
18.18Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
18.18Consensusadenosine_offOrthosteric Liganda1_off a2_off
18.18Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
18.18Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
18.18Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
18.18Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
18.18Consensusdp_offOrthosteric Liganddp2_off
18.18Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
18.18Consensusep_offOrthosteric Ligandep4_off
18.18Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
18.18Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
18.18Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
18.18Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
18.18Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.18Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.18Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
18.18Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
18.18Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
18.18Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
18.18Consensustrace-amine_onOrthosteric Ligandta1_on
17.95Single3OE0CVX153OE0-CXCR4-CVX15
17.95Single6PT2KGCHM076PT2-δ-KGCHM07
17.95Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
17.95Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
17.95Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
17.95Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
17.95Single9B5YLong-Acting PTH9B5Y-PTH1-Long-Acting PTH-chim(NtGi1-Gq)/β1/γ2
17.95Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
17.95Consensusclass-b1_class-b2_cons_onOrthosteric Ligandclass-b1_on class-b2_on
17.95Consensusclass-b1_class-b2_cons_on_gpOrthosteric Ligandclass-b1_on_gp class-b2_on_gp
17.86Single9EE9Adenosine9EE9-A2A-Adenosine-Gs/β1/γ2
17.78Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
17.78Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
17.65Single3P0GBI1671073P0G-β2-BI167107
17.65Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
17.65Single4U15Tiotropium4U15-M3-Tiotropium
17.65Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
17.65Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
17.65Single5V54Methiothepin5V54-5-HT1B-Methiothepin
17.65Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
17.65Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
17.65Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
17.65Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
17.65Single6OL9Tiotropium6OL9-M5-Tiotropium
17.65Single7F1TMIP-1a7F1T-CCR5-MIP-1a
17.65Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
17.65Single7PX4PSB-21137PX4-A2A-PSB-2113
17.65Single7T9NDPPC7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
17.65Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
17.65Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
17.65Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
17.65Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
17.65Single8EA0Iperoxo8EA0-M3-Iperoxo
17.65Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
17.65Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
17.65Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
17.65Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
17.65Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
17.65Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
17.65Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
17.65Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
17.65Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
17.65Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
17.65Single8ZWFJR14a8ZWF-C3aB-JR14a
17.65Single9IK9SST analogue9IK9-SST1-SST analogue-Gi1/β1/γ2
17.65Consensus5ht1_offOrthosteric Ligand5ht1b_off
17.65Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
17.65Consensusa2_onOrthosteric Liganda2b_on
17.65Consensusa2_on_gpOrthosteric Liganda2b_on_gp
17.65Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
17.65Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
17.65Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
17.65Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
17.65Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
17.65Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
17.65Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
17.65Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
17.65Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
17.65Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
17.65Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
17.65Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
17.65Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
17.65Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
17.50Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
17.50Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
17.24Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
17.24Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
17.24Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
17.24Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
17.24Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
17.24Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
17.24Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
17.24Single9LRCHistamine9LRC-H4-Histamine
17.24Single9LREHistamine9LRE-H4-Histamine-Gi1/β1/γ2
17.24Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
17.24Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
17.14Single3D4STimolol3D4S-β2-Timolol
17.14Single4LDEBI1671074LDE-β2-BI167107
17.14Single4N4WSANT-14N4W-SMO-SANT-1
17.14Single4XEENeurotensin4XEE-NTS1-Neurotensin
17.14Single4XESNeurotensin4XES-NTS1-Neurotensin
17.14Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
17.14Single5CXVTiotropium5CXV-M1-Tiotropium
17.14Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
17.14Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
17.14Single6CM4Risperidone6CM4-D2-Risperidone
17.14Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
17.14Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
17.14Single6MXTSalmeterol6MXT-β2-Salmeterol
17.14Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
17.14Single6YVRNTS8-136YVR-NTS1-NTS8-13
17.14Single6ZG4HTL00099366ZG4-M1-HTL0009936
17.14Single7DFPSpiperone7DFP-D2-Spiperone
17.14Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
17.14Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
17.14Single7K15MKD0467K15-BLT1-MKD046-Na
17.14Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
17.14Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
17.14Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
17.14Single7YITNalfurafine7YIT-κ-Nalfurafine
17.14Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.14Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
17.14Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
17.14Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
17.14Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
17.14Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
17.14Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
17.14Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
17.14Single8JJLOlodaterol8JJL-β2-Olodaterol
17.14Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
17.14Single8JWY2-1188JWY-A2A-2-118
17.14Single8JWZAB9288JWZ-A2A-AB928-Na
17.14Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
17.14Single8XJNCloprosetnol8XJN-TXA2-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
17.14Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
17.14Single8XYIVUF106618XYI-CXCR3-VUF10661
17.14Single9AU0BW245C9AU0-DP1-BW245C-Gs/β1/γ2
17.14Single9GL2Befiradol9GL2-5-HT1A-Befiradol-Gs/β1/γ2
17.14Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
17.14Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
17.14Single9M4QDoxazosin9M4Q-Alpha1A-Doxazosin
17.14Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
17.14Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
17.14Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
17.14Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
17.14Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
17.14Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
17.14Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
17.14Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
17.14Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
17.14Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
17.14Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
17.14Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
17.14Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
17.14Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
17.14Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
17.14Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
17.14Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
17.14Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
17.14Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
17.14Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
17.07Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
17.07Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
17.07Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
17.07Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
17.07Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
17.07Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
17.07Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
17.07Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
16.67Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
16.67Single4BUONeurotensin4BUO-NTS1-Neurotensin
16.67Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
16.67Single4O9RCyclopamine4O9R-SMO-Cyclopamine
16.67Single5L7IVismodegib5L7I-SMO-Vismodegib
16.67Single6H7LDobutamine6H7L-β1-Dobutamine
16.67Single6IBLArformoterol6IBL-β1-Arformoterol
16.67Single6LI0C176LI0-GPR52-C17
16.67Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
16.67Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
16.67Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
16.67Single7SK3CXCL127SK3-ACKR3-CXCL12
16.67Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
16.67Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
16.67Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
16.67Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
16.67Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
16.67Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
16.67Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-SBI-553-chim(NtGi1-Go)/β1/γ2
16.67Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
16.67Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
16.67Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
16.67Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
16.67Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
16.67Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
16.67Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
16.67Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
16.67Single8S2TIsoprenaline8S2T-β1-Isoprenaline-chim(NtGi1-Gs)/β1/γ2
16.67Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
16.67Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
16.67Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
16.67Single8XJOU466198XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
16.67Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
16.67Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
16.67Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
16.67Single8YN7Immethridine8YN7-H3-Immethridine-Go/β1/γ2
16.67Single8ZWGJR14a8ZWG-C3aB-JR14a-Gi1/β1/γ2
16.67Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
16.67Single9AS02-bromo-LSD9AS0-5-HT2A-2-bromo-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
16.67Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
16.67Single9LMPNE52-QQ579LMP-GPR4-NE52-QQ57
16.67Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
16.67Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
16.67Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
16.67Consensuscck_onOrthosteric Ligandccka_on cckb_on
16.67Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
16.67Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
16.67Consensusfp-alpha_onOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
16.67Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
16.67Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
16.67Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
16.67Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
16.67Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
16.67Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
16.67Consensustp_onOrthosteric Ligand8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Consensustp_on_gpOrthosteric Ligand8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
16.28Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
16.28Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
16.28Single8W8XBeta-MSH8W8X-MC3-β-MSH-Ca-Gs/β1/γ2
16.22Single5ZTYAM102575ZTY-CB2-AM10257
16.22Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
16.22Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
16.22Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
16.22Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
16.22Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
16.22Single7XN9L-054,5227XN9-SST2-L-054,522
16.22Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
16.22Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
16.22Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
16.22Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
16.22Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
16.22Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
16.22Single8Y72Peptide8Y72-μ-Peptide-BMS-986122-Gi1/β1/γ2
16.22Single9IPYJR14a9IPY-C3aB-JR14a
16.22Single9V2NMacimorelin9V2N-Ghrelin-Macimorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
16.22Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
16.22Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
16.22Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
16.22Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
16.22Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
16.13Single3PWHZM-2413853PWH-A2A-ZM-241385
16.13Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
16.13Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
16.13Single4BWBNeurotensin4BWB-NTS1-Neurotensin
16.13Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
16.13Single4QINSAG1.54QIN-SMO-SAG1.5
16.13Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
16.13Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
16.13Single5U09Taranabant5U09-CB1-Taranabant
16.13Single6AKXA4R6AKX-CCR5-A4R
16.13Single6AKYMaraviroc6AKY-CCR5-Maraviroc
16.13Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
16.13Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
16.13Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
16.13Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
16.13Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
16.13Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
16.13Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
16.13Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
16.13Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
16.13Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
16.13Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
16.13Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
16.13Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
16.13Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.13Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
16.13Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
16.13Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
16.13Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
16.13Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
16.13Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
16.13Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
16.13Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
16.13Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
16.13Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
16.13Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
16.13Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
16.13Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
16.13Single8Y0HVUF114188Y0H-CXCR3-VUF11418
16.13Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go/β1/γ2
16.13Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ2
16.13Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
16.13Single8YYWAlpha-ketoglutarate8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
16.13Single9EEAAdenosine9EEA-A2A-Adenosine-Gs/β1/γ2
16.13Single9KPESA09KPE-TAS2R16-SA0-Gi1/β1/γ2
16.13Consensusalpha2_offOrthosteric Ligandalpha2c_off
16.13Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
16.13Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
16.13Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
16.13Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
16.13Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
16.13Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
16.13Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
15.91Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
15.91Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
15.79Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
15.79Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
15.79Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
15.79Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
15.79Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
15.79Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
15.79Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
15.79Single8PKMBefiradol8PKM-5-HT1A-Befiradol-Gi1/β1/γ1
15.79Single8XWNCXCL88XWN-CXCR2-CXCL8
15.79Single8ZBJSomatostatin-148ZBJ-SST5-Somatostatin-14-Gi1/β1/γ2
15.79Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
15.79Single9BUECagrilintide9BUE-CT-Cagrilintide-Gs/β1/γ2
15.79Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
15.79Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
15.79Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
15.79Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
15.79Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
15.79Consensussomatostatin_offOrthosteric Ligandsst2_off
15.62Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
15.62Single4MBSMaraviroc4MBS-CCR5-Maraviroc
15.62Single5IU7Q274563465IU7-A2A-Q27456346-Na
15.62Single5JTBZM-2413855JTB-A2A-ZM-241385
15.62Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
15.62Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
15.62Single6AQFZM-2413856AQF-A2A-ZM-241385
15.62Single6PS0S-Carazolol6PS0-β2-S-Carazolol
15.62Single6PS4ICI118-5516PS4-β2-ICI118-551
15.62Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
15.62Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
15.62Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
15.62Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
15.62Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
15.62Single7AROLUF58337ARO-A2A-LUF5833-Na
15.62Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
15.62Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
15.62Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
15.62Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
15.62Single7T94Acetylcholine7T94-M2-Acetylcholine-LY2119620-chim(NtGi1-Go)/β1/γ2
15.62Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
15.62Single7UL3Famotidine7UL3-H2-Famotidine
15.62Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
15.62Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
15.62Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
15.62Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
15.62Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
15.62Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
15.62Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
15.62Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
15.62Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
15.62Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
15.62Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
15.62Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.62Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.62Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
15.62Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
15.62Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
15.62Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
15.62Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
15.62Single8IHKAcifran8IHK-HCA3-Acifran
15.62Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
15.62Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
15.62Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
15.62Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
15.62Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
15.62Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
15.62Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
15.62Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
15.62Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
15.62Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
15.62Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
15.62Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
15.62Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
15.62Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
15.62Single9AS5Mescaline9AS5-5-HT2A-Mescaline
15.62Single9AS6Mescaline9AS6-5-HT2A-Mescaline-chim(NtGi1-Gs-CtGq)/β1/γ2
15.62Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
15.62Consensusa2_offOrthosteric Liganda2a_off
15.62Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
15.62Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
15.62Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
15.62Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
15.38Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
15.38Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
15.38Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
15.38Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
15.38Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
15.38Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
15.38Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
15.38Single9IK8SST analogue9IK8-SST1-SST analogue-Gi1/β1/γ2
15.38Single9IQRMuscarinic toxin 39IQR-α2a-Muscarinic toxin 3
15.38Single9KFIRelaxin-39KFI-RXFP3-Relaxin-3-Gi2/β1/γ2
15.38Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
15.38Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
15.38Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
15.22Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
15.15Single2Y01Dobutamine2Y01-β1-Dobutamine
15.15Single2Y04Salbutamol2Y04-β1-Salbutamol
15.15Single3EMLZM-2413853EML-A2A-ZM-241385
15.15Single3NY8ICI118-5513NY8-β2-ICI118-551
15.15Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
15.15Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
15.15Single4GBRS-Carazolol4GBR-β2-S-Carazolol
15.15Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
15.15Single4MQSIperoxo4MQS-M2-Iperoxo
15.15Single4QKX35V4QKX-β2-35V
15.15Single4U14Tiotropium4U14-M3-Tiotropium
15.15Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
15.15Single5DHHSB-6121115DHH-NOP-SB-612111
15.15Single5DSGTiotropium5DSG-M4-Tiotropium
15.15Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
15.15Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
15.15Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
15.15Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
15.15Single5TGZAM65385TGZ-CB1-AM6538
15.15Single5UENDU1725UEN-A1-DU172
15.15Single5UIGCmpd-15UIG-A2A-Cmpd-1
15.15Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
15.15Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
15.15Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
15.15Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
15.15Single6D27CAY104716D27-DP2-CAY10471
15.15Single6GPSMK08126GPS-CCR2-MK0812
15.15Single6H7MSalbutamol6H7M-β1-Salbutamol
15.15Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
15.15Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/β1/γ2
15.15Single6S0LZM-2413856S0L-A2A-ZM-241385
15.15Single6TOTLemborexant6TOT-OX1-Lemborexant
15.15Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.15Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
15.15Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
15.15Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
15.15Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
15.15Single7BU7BI1671077BU7-β1-BI167107
15.15Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
15.15Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
15.15Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
15.15Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
15.15Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
15.15Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
15.15Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
15.15Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
15.15Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
15.15Single7UL4Alvimopan7UL4-μ-Alvimopan
15.15Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
15.15Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
15.15Single7V3ZCP559407V3Z-CB1-CP55940
15.15Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
15.15Single7YXAONO-54306087YXA-S1P5-ONO-5430608
15.15Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
15.15Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
15.15Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
15.15Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
15.15Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
15.15Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.15Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.15Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.15Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.15Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.15Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.15Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.15Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.15Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.15Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.15Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
15.15Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
15.15Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
15.15Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
15.15Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
15.15Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
15.15Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
15.15Single8JJOAlprenolol8JJO-β2-Alprenolol
15.15Single8JXRLSD8JXR-D1-LSD
15.15Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
15.15Single8PJKST1718PJK-5-HT1A-ST171-Gi1/β1/γ1
15.15Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
15.15Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
15.15Single8T1WCVN4248T1W-GPR6-CVN424
15.15Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
15.15Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
15.15Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.15Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.15Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.15Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.15Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
15.15Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
15.15Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
15.15Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
15.15Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
15.15Single8YN8Proxyfan8YN8-H3-Proxyfan-Go/β1/γ2
15.15Single9AS1DMT9AS1-5-HT2A-DMT
15.15Single9CHXS-Carazolol9CHX-β2-S-Carazolol
15.15Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
15.15Single9H37A1IR09H37-A2A-A1IR0-Na
15.15Single9IMATalquetamab9IMA-GPRC5D-Talquetamab
15.15Single9JGKBalovaptan9JGK-5-HT2B-Balovaptan
15.15Single9PQD(6m)-1-methyl-6-(1,2,5,6-tetrahydropyridin-3-yl)-1h-indole9PQD-α2a-(6m)-1-methyl-6-(1,2,5,6-tetrahydropyridin-3-yl)-1h-indole
15.15Consensus5ht5_onOrthosteric Ligand5ht5a_on
15.15Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
15.15Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
15.15Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
15.15Consensusalpha2_onOrthosteric Ligandalpha2b_on
15.15Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
15.15Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
15.15Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
15.15Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
15.15Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
15.15Consensusdopamine_offOrthosteric Ligandd2_off d3_off
15.15Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
15.15Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
15.15Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
15.15Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
15.15Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
15.15Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
15.15Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
15.00Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
15.00Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
15.00Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
15.00Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.00Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
15.00Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
15.00Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
15.00Single9M1OMorphine-Modulating Neuropeptide B9M1O-NPFF2-Morphine-Modulating Neuropeptide B-Gi1/β1/γ2
15.00Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
15.00Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
14.71Single2RH1S-Carazolol2RH1-β2-S-Carazolol
14.71Single2Y00Dobutamine2Y00-β1-Dobutamine
14.71Single2Y03Isoprenaline2Y03-β1-Isoprenaline
14.71Single2YCWS-Carazolol2YCW-β1-S-Carazolol
14.71Single4JKVTaladegib4JKV-SMO-Taladegib
14.71Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
14.71Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
14.71Single5D6LS-Carazolol5D6L-β2-S-Carazolol
14.71Single5JQHS-Carazolol5JQH-β2-S-Carazolol
14.71Single5N2SPSB365N2S-A1-PSB36
14.71Single5T1ABMS-6815T1A-CCR2-BMS-681-PubChem 12093170
14.71Single5WIUNemonapride5WIU-D4-Nemonapride
14.71Single5WIVNemonapride5WIV-D4-Nemonapride-Na
14.71Single5X7DS-Carazolol5X7D-β2-S-Carazolol-Cmpd-15
14.71Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
14.71Single6E67BI1671076E67-β2-BI167107-Gs(CT)
14.71Single6GPXMK08126GPX-CCR2-MK0812
14.71Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
14.71Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
14.71Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
14.71Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
14.71Single6PS6Timolol6PS6-β2-Timolol
14.71Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
14.71Single6TP6Filorexant6TP6-OX1-Filorexant
14.71Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
14.71Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
14.71Single7C4SS1P7C4S-S1P3-S1P
14.71Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
14.71Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
14.71Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
14.71Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
14.71Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
14.71Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
14.71Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
14.71Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
14.71Single8GNEKW-63568GNE-A2A-KW-6356-Na
14.71Single8JXSPF-61428JXS-D1-PF-6142
14.71Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
14.71Single8QOTNanobody-E8QOT-μ-Nanobody-E
14.71Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
14.71Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
14.71Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
14.71Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
14.71Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
14.71Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
14.71Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
14.71Single8ZMFA1L108ZMF-5-HT2C-A1L10
14.71Single8ZVZBW245C8ZVZ-DP1-BW245C-Gs/β1/γ2
14.71Single9ARZ2-bromo-LSD9ARZ-5-HT2A-2-bromo-LSD
14.71Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
14.71Single9F33FOB02-04A9F33-D3-FOB02-04A-Go/β1/γ2
14.71Single9F34FOB02-04A9F34-D3-FOB02-04A-Go/β1/γ2
14.71Single9I52A1IZU9I52-D1-A1IZU-Gs/β1/γ2
14.71Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
14.71Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
14.71Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
14.71Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
14.71Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
14.71Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
14.71Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
14.71Consensusadgrg2_onOrthosteric Ligand7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
14.71Consensusadgrg2_on_gpOrthosteric Ligand7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
14.71Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
14.71Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
14.71Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
14.71Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
14.71Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
14.71Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
14.71Consensusamine_offonOrthosteric Ligandamine_off amine_on
14.71Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
14.71Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
14.71Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
14.71Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
14.71Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
14.71Consensusblt_offOrthosteric Ligandblt1_off
14.71Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
14.71Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
14.71Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
14.71Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
14.71Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
14.71Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
14.71Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
14.63Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
14.63Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
14.63Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
14.63Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
14.63Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
14.29Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
14.29Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
14.29Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
14.29Single4BV0Neurotensin4BV0-NTS1-Neurotensin
14.29Single4DJHJDTic4DJH-κ-JDTic
14.29Single5D5AS-Carazolol5D5A-β2-S-Carazolol
14.29Single5D5BS-Carazolol5D5B-β2-S-Carazolol
14.29Single5V56TC1145V56-SMO-TC114
14.29Single5V57TC1145V57-SMO-TC114
14.29Single5XR8AM8415XR8-CB1-AM841
14.29Single5XRAAM115425XRA-CB1-AM11542
14.29Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
14.29Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
14.29Single6H7JIsoprenaline6H7J-β1-Isoprenaline
14.29Single6J21Aprepitant6J21-NK1-Aprepitant
14.29Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
14.29Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
14.29Single6TQ7SB-3348676TQ7-OX1-SB-334867
14.29Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
14.29Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
14.29Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
14.29Single7FEECP559407FEE-CB1-CP55940-ZCZ011
14.29Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
14.29Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
14.29Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
14.29Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
14.29Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
14.29Single7P2L4YI7P2L-mGlu5-4YI
14.29Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
14.29Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
14.29Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
14.29Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
14.29Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
14.29Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
14.29Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
14.29Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
14.29Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
14.29Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
14.29Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
14.29Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
14.29Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
14.29Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
14.29Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
14.29Single8Y73Peptide8Y73-μ-Peptide-MPAM-15-Gi1/β1/γ2
14.29Single8ZW0PGD28ZW0-DP1-PGD2-Gs/β1/γ2
14.29Single9AS9RS130-1809AS9-5-HT2A-RS130-180
14.29Single9ASARS130-1809ASA-5-HT2A-RS130-180-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
14.29Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
14.29Single9BJKNaloxone9BJK-μ-Naloxone-NAM
14.29Single9I54A1IZV9I54-D1-A1IZV-Gs/β1/γ2
14.29Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
14.29Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
14.29Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
14.29Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
14.29Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
14.29Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
14.29Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
14.29Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
14.29Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
14.29Consensusneurotensin_onOrthosteric Ligandnts1_on
14.29Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
14.29Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
13.89Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
13.89Single4AMIBucindolol4AMI-β1-Bucindolol
13.89Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
13.89Single4RWADIPP-NH24RWA-δ-DIPP-NH2
13.89Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
13.89Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
13.89Single6IIURamatroban6IIU-TXA2-Ramatroban
13.89Single6KQICP559406KQI-CB1-CP55940-Org27569
13.89Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
13.89Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
13.89Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
13.89Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
13.89Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.89Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
13.89Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.89Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
13.89Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
13.89Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
13.89Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
13.89Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
13.89Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
13.89Single9BJKNAM9BJK-μ-Naloxone-NAM
13.89Single9DGIZ85267113509DGI-CB1-Z8526711350
13.89Single9GGGI-BOP9GGG-TXA2-I-BOP-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.89Consensusalpha1_offOrthosteric Ligandalpha1a_off
13.89Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
13.89Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
13.89Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
13.89Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
13.89Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
13.89Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
13.89Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
13.89Consensusorexin_onOrthosteric Ligandox2_on
13.89Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.89Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.79Single8A2OTheophylline8A2O-A2A-Theophylline-Na
13.79Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.79Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
13.64Single8W8WAlpha-MSH8W8W-MC3-α-MSH-Ca-Gs/β1/γ2
13.64Single9KDFRES-701-39KDF-ETB-RES-701-3
13.64Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
13.51Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
13.51Single5X93K-87945X93-ETB-K-8794
13.51Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
13.51Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
13.51Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
13.51Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
13.51Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
13.51Single7UM4AS26747237UM4-5-HT5A-AS2674723
13.51Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
13.51Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
13.51Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
13.51Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
13.51Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
13.51Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
13.51Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
13.51Single8JPFNeurotensin8JPF-NTS1-Neurotensin-SBI-553
13.51Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
13.51Single8XVUCXCL28XVU-CXCR2-CXCL2
13.51Single8XWFCXCL38XWF-CXCR2-CXCL3
13.51Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
13.51Single8ZPLHF511168ZPL-CXCR4-HF51116
13.51Single9GG5U466199GG5-TXA2-U46619-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.51Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
13.51Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
13.51Consensuschemerin_onOrthosteric Ligandcml1_on
13.51Consensusendothelin_offOrthosteric Ligandetb_off
13.51Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
13.51Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
13.51Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
13.51Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
13.33Single4XNWMRS25004XNW-P2Y1-MRS2500
13.33Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
13.33Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
13.33Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.33Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
13.33Single8IW72-Phenylethylamine8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
13.33Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
13.33Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
13.33Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
13.33Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
13.33Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
13.33Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
13.33Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
13.33Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
13.33Single9JHJC18:0 Ceramide9JHJ-FPR2-ALX-C18:0 Ceramide-Gi1/β1/γ2
13.33Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
13.16Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
13.16Single6PT3DPI-2876PT3-δ-DPI-287
13.16Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
13.16Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
13.16Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
13.16Single8XQJJN2418XQJ-Apelin-JN241
13.16Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
13.16Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
13.16Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
13.16Single9CGKC5-Quino9CGK-δ-C5-Quino-Gi1/β1/γ2
13.16Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
13.16Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
13.04Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
12.90Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
12.90Single3OE9IT1t3OE9-CXCR4-IT1t
12.90Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
12.90Single7SRQLSD7SRQ-5-HT2B-LSD
12.90Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
12.90Single7V68Iperoxo7V68-M4-Iperoxo-LY2119620-Gi1/β1/γ2
12.90Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
12.90Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
12.90Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
12.90Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
12.90Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
12.90Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
12.90Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
12.90Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
12.90Single9IZDCHBA9IZD-HCA1-CHBA-Gi1/β1/γ2
12.90Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
12.82Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
12.82Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
12.82Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
12.82Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
12.82Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
12.82Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
12.82Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
12.82Single9M4TSilodosin9M4T-Alpha1A-Silodosin
12.82Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
12.82Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
12.82Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
12.50Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
12.50Single4S0VSuvorexant4S0V-OX2-Suvorexant
12.50Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
12.50Single5ZKQABT-4915ZKQ-PAF-ABT-491
12.50Single6B73MP11046B73-κ-MP1104
12.50Single6HLOAprepitant6HLO-NK1-Aprepitant
12.50Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
12.50Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
12.50Single6ME2Ramelteon6ME2-MT1-Ramelteon
12.50Single6ME9Ramelteon6ME9-MT2-Ramelteon
12.50Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
12.50Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
12.50Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
12.50Single6TPJSuvorexant6TPJ-OX2-Suvorexant
12.50Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
12.50Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
12.50Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
12.50Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
12.50Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
12.50Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
12.50Single7VVOPTH7VVO-PTH1-PTH-Gs/β1/γ2
12.50Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
12.50Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
12.50Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
12.50Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
12.50Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
12.50Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
12.50Single8GNGIstradefylline8GNG-A2A-Istradefylline
12.50Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
12.50Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
12.50Single8U4PAMD31008U4P-CXCR4-AMD3100-Gi1/β1/γ2
12.50Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
12.50Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
12.50Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
12.50Single8YYWAlpha-ketoglutarate8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
12.50Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
12.50Single9J0FNADH9J0F-P2Y14-NADH-Gi1/β1/γ2
12.50Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
12.50Single9K6LSA09K6L-TAS2R16-SA0-Gi2/β1/γ2
12.50Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
12.50Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
12.50Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
12.50Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
12.50Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
12.50Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
12.50Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
12.50Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
12.50Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
12.20Single6W25SHU91196W25-MC4-SHU9119-Ca
12.20Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
12.20Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
12.12Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
12.12Single3REYXAC3REY-A2A-XAC
12.12Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
12.12Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
12.12Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
12.12Single4ZJCSB-6740424ZJC-OX1-SB-674042
12.12Single5UVIZM-2413855UVI-A2A-ZM-241385
12.12Single6FFIMMPEP6FFI-mGlu5-MMPEP
12.12Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
12.12Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
12.12Single6KUXRS-799486KUX-α2a-RS-79948
12.12Single6MH8ZM-2413856MH8-A2A-ZM-241385
12.12Single6PS5S-Propranolol6PS5-β2-S-Propranolol
12.12Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
12.12Single6TP3Nemorexant6TP3-OX1-Nemorexant
12.12Single6TPGEMPA6TPG-OX2-EMPA
12.12Single6V9SGTPL114036V9S-OX1-GTPL11403
12.12Single6VI4JDTic6VI4-κ-JDTic
12.12Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
12.12Single6ZG9GSK10347026ZG9-M1-GSK1034702
12.12Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
12.12Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
12.12Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
12.12Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
12.12Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
12.12Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
12.12Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.12Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
12.12Single7UTZDPPC7UTZ-TSH-TR1402-DPPC-Gs/β1/γ2
12.12Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
12.12Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
12.12Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.12Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
12.12Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
12.12Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
12.12Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
12.12Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
12.12Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
12.12Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
12.12Single8K9LDamgo8K9L-μ-Damgo-BMS-986122-Gi3/β1/γ1
12.12Single8RLNLUF58348RLN-A2A-LUF5834
12.12Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.12Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.12Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
12.12Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
12.12Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
12.12Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
12.12Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
12.12Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
12.12Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
12.12Single8Y6YGLPG09748Y6Y-FFA2-GLPG0974
12.12Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
12.12Single8ZPNAMD31008ZPN-CXCR4-AMD3100
12.12Single9AS3LSD9AS3-5-HT2A-LSD
12.12Single9AS4LSD9AS4-5-HT2A-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
12.12Single9BA0A1AKN9BA0-CB1-A1AKN
12.12Single9JMDAzithromycin9JMD-Motilin-Azithromycin-chim(Gs-CtGq)/β1/γ2
12.12Single9KPDSA09KPD-TAS2R16-SA0-chim(Gs-CtGt3)/β1/γ2
12.12Single9LRDHistamine9LRD-H1-Histamine-Gi1/β1/γ2
12.12Single9M2FNeuropeptide FF9M2F-NPFF1-Neuropeptide FF-Gi1/β1/γ2
12.12Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
12.12Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
12.12Consensusalpha1_onOrthosteric Ligandalpha1a_on
12.12Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
12.12Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
12.12Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
12.12Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
12.12Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
12.12Consensusgrh_offOrthosteric Ligandgnrh1_off
12.12Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
12.12Consensusopsins_offOrthosteric Ligandrhodopsin_off
12.12Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
12.12Consensussensory_offOrthosteric Ligandopsins_off
11.90Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
11.76Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
11.76Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
11.76Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
11.76Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
11.76Single4DAJTiotropium4DAJ-M3-Tiotropium
11.76Single4EJ4Naltrindole4EJ4-δ-Naltrindole
11.76Single4QIMANTA XV4QIM-SMO-ANTA XV
11.76Single5DHGC-355DHG-NOP-C-35
11.76Single5T04Neurotensin5T04-NTS1-Neurotensin
11.76Single6DRXLisuride6DRX-5-HT2B-Lisuride
11.76Single6FFHFenobam6FFH-mGlu5-Fenobam
11.76Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
11.76Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
11.76Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
11.76Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
11.76Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
11.76Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
11.76Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
11.76Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
11.76Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
11.76Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
11.76Single7WC7Lisuride7WC7-5-HT2A-Lisuride
11.76Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
11.76Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
11.76Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
11.76Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
11.76Single8CU6LJ-45178CU6-A2A-LJ-4517
11.76Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
11.76Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
11.76Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
11.76Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
11.76Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
11.76Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
11.76Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
11.76Single8TH3AT118-H Nanobody8TH3-AT1-AT118-H Nanobody
11.76Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
11.76Single8X63Mepyramine8X63-H1-Mepyramine
11.76Single8X64Desloratadine8X64-H1-Desloratadine
11.76Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
11.76Single8ZYYNeurotensin peptide 8-138ZYY-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
11.76Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
11.76Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
11.76Single9IYAONO-97105319IYA-GPR55-ONO-9710531
11.76Single9PLNN-(5-methylnaphthalen-1-yl)pyridin-4-amine9PLN-α2a-N-(5-methylnaphthalen-1-yl)pyridin-4-amine
11.76Single9PLON-(5-methylnaphthalen-1-yl)pyridin-4-amine9PLO-α2a-N-(5-methylnaphthalen-1-yl)pyridin-4-amine-Go/β1/γ2
11.76Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
11.76Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
11.76Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
11.76Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
11.76Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
11.76Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
11.76Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
11.76Consensushistamine_offOrthosteric Ligandh1_off
11.63Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
11.43Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
11.43Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
11.43Single5TVNLSD5TVN-5-HT2B-LSD
11.43Single5WQCEMPA5WQC-OX2-EMPA
11.43Single6LUQHaloperidol6LUQ-D2-Haloperidol
11.43Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
11.43Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
11.43Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
11.43Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
11.43Single7SINNPS-21437SIN-CaS-NPS-2143
11.43Single7SINNPS-21437SIN-CaS-NPS-2143
11.43Single7WC6LSD7WC6-5-HT2A-LSD
11.43Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
11.43Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.43Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
11.43Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
11.43Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
11.43Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
11.43Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
11.43Single9ARYSerotonin9ARY-5-HT2A-Serotonin-chim(NtGi1-Gs-CtGq)/β1/γ2
11.43Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
11.43Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
11.43Single9GE2ML1849GE2-GPR55-ML184-chim(NtGi1-G13)/β1/γ2
11.43Single9HC04YI9HC0-mGlu5-4YI
11.43Single9K07DSO-5a9K07-BB3-DSO-5a-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.43Single9KPFSA09KPF-TAS2R16-SA0-Gi1/β1/γ2
11.43Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
11.43Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
11.11Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
11.11Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
11.11Single5TZRMK86665TZR-FFA1-MK8666
11.11Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
11.11Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
11.11Single6WGTLSD6WGT-5-HT2A-LSD
11.11Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
11.11Single7B6WCyclazosin7B6W-α1b-Cyclazosin
11.11Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
11.11Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
11.11Single7R0CAVP7R0C-V2-AVP-Arrestin2
11.11Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
11.11Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
11.11Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
11.11Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.11Single8GDBPGE28GDB-EP4-PGE2-Gs/β1/γ2
11.11Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
11.11Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
11.11Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
11.11Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
11.11Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
11.11Single8YNTSNAP-948478YNT-MCH1-SNAP-94847
11.11Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
11.11Single9EGOYVF9EGO-CB1-YVF-Gi1/β1/γ2
11.11Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
11.11Single9UY3Anamorelin9UY3-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
11.11Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
11.11Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
10.87Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
10.81Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
10.81Single5TZYMK8666; AP85TZY-FFA1-MK8666; AP8
10.81Single5X33BIIL2605X33-BLT1-BIIL260
10.81Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
10.81Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
10.81Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
10.81Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
10.81Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
10.81Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
10.81Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
10.81Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
10.81Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
10.81Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
10.81Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
10.81Single8JD3JNJ-404118138JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
10.81Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.81Single8XQJJN2418XQJ-Apelin-JN241
10.81Single8XWACXCL18XWA-CXCR2-CXCL1
10.81Single8XWMCXCL68XWM-CXCR2-CXCL6
10.81Single8XWSCXCL58XWS-CXCR2-CXCL5
10.81Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
10.81Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
10.81Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
10.71Single8GEJConstrained Epinephrine8GEJ-β2-Constrained Epinephrine-Gs/β1/γ2
10.53Single5CGDHTL142425CGD-mGlu5-HTL14242
10.53Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
10.53Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
10.53Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
10.53Single8XVJMacitentan8XVJ-ETA-Macitentan
10.53Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
10.53Single9CGJC6-Quino9CGJ-δ-C6-Quino-Gi1/β1/γ2
10.34Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
10.34Single7V68LY21196207V68-M4-Iperoxo-LY2119620-Gi1/β1/γ2
10.34Single7XKDBeta-Hydroxyandrosterone7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
10.34Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
10.34Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
10.34Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
10.34Single8PWNTheophylline8PWN-A2A-Theophylline
10.34Single8X9S5alpha-DHT8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
10.34Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
10.26Single6KNMJN241-96KNM-Apelin-JN241-9
10.26Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
10.26Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
10.26Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
10.26Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
10.26Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
10.26Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
10.26Single9JH6C20:0 Ceramide9JH6-CysLT2-C20:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
10.26Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
10.26Consensuskisspeptin_onOrthosteric Ligandkiss1_on
10.00Single2HPYAll-trans-Retinal2HPY-Rhodopsin-All-trans-Retinal
10.00Single3RFMCaffeine3RFM-A2A-Caffeine
10.00Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
10.00Single6XBM5LWE6XBM-SMO-5LWE-Gi1/β1/γ2
10.00Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
10.00Single8IWM2-Phenylethylamine8IWM-TA9-2-Phenylethylamine
10.00Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
10.00Single8KIGSHU91198KIG-MC3-SHU9119-Ca
10.00Single8WC5Tetramethylammonium Ion8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
10.00Single8WKYPG-9348WKY-MC4-PG-934
10.00Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
10.00Single8Y02Retinal8Y02-OPN1SW-Retinal-Gi1/β1/γ2
10.00Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
10.00Single9CHUNoradrenaline9CHU-β2-Noradrenaline
10.00Single9J0IUDP-Glucuronic acid9J0I-P2Y14-UDP-Glucuronic acid-Gi1/β1/γ2
10.00Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
10.00Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
10.00Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
10.00Consensusp2y_offOrthosteric Ligandp2y1_off
9.76Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
9.76Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
9.76Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
9.76Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
9.68Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
9.68Single3OE6IT1t3OE6-CXCR4-IT1t
9.68Single3UZAGTPL92363UZA-A2A-GTPL9236
9.68Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
9.68Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
9.68Single6ME5Agomelatine6ME5-MT1-Agomelatine
9.68Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
9.68Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
9.68Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
9.68Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
9.68Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
9.68Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
9.68Consensus5ht2_onOrthosteric Ligand5ht2b_on
9.68Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.68Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
9.68Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
9.68Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
9.52Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
9.52Single8W8YGamma-MSH8W8Y-MC3-γ-MSH-Ca-Gs/β1/γ2
9.52Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
9.52Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
9.38Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
9.38Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
9.38Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
9.38Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
9.38Single3PBLEticlopride3PBL-D3-Eticlopride
9.38Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
9.38Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
9.38Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
9.38Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
9.38Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
9.38Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
9.38Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
9.38Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.38Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
9.38Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
9.38Single8HSCFab0468HSC-GPR20-Fab046-Gi1/β1/γ2
9.38Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab
9.38Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
9.38Single8YKDDehydroepiandrosterone8YKD-ADGRG2-Dehydroepiandrosterone-chim(NtGi1-Gs)/β1/γ2
9.38Single8YN2Histamine8YN2-H1-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
9.38Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
9.38Single9AS2DMT9AS2-5-HT2A-DMT-chim(NtGi1-Gs-CtGq)/β1/γ2
9.38Single9B9Y7DY9B9Y-CB1-7DY
9.38Single9E7RGB889E7R-PAR2-GB88-chim(NtGi1L-Gs-CtGq)/β1/γ2
9.38Single9EPRRetinal9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
9.38Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
9.38Single9IXJHistamine9IXJ-H2-Histamine-Gs/β1/γ2
9.38Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
9.38Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
9.38Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg4_on
9.38Consensusadgrg_on_gpOrthosteric Ligandadgrg2_on_gp adgrg4_on_gp
9.38Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
9.30Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
9.30Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
9.30Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
9.09Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
9.09Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
9.09Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
9.09Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
9.09Single3ODUIT1t3ODU-CXCR4-IT1t
9.09Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
9.09Single5WS3EMPA5WS3-OX2-EMPA
9.09Single6DS0Ly2660976DS0-5-HT2B-Ly266097
9.09Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
9.09Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
9.09Single6TODEMPA6TOD-OX1-EMPA-Na
9.09Single7BR3Elagolix7BR3-GnRH1-Elagolix
9.09Single7F8ULintitript7F8U-CCKA-Lintitript
9.09Single7F8YDevazepide7F8Y-CCKA-Devazepide
9.09Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
9.09Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.09Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
9.09Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
9.09Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
9.09Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
9.09Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
9.09Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
9.09Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
9.09Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
9.09Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
9.09Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
9.09Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
9.09Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
9.09Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.09Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.09Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
9.09Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
9.09Single9H2XA1IR19H2X-A2A-A1IR1-Na
9.09Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
9.09Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.09Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
9.09Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
9.09Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
9.09Consensusorexin_offOrthosteric Ligandox2_off ox1_off
9.09Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
9.09Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
9.09Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
9.09Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
8.82Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
8.82Single3RZECidoxepin3RZE-H1-Cidoxepin
8.82Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
8.82Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
8.82Single6A94Zotepine6A94-5-HT2A-Zotepine
8.82Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
8.82Single6IQLL7458706IQL-D4-L745870
8.82Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
8.82Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
8.82Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
8.82Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
8.82Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
8.82Single7VV6C48/807VV6-MRGPRX2-C48/80
8.82Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
8.82Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
8.82Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
8.82Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
8.82Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
8.82Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
8.82Single8YRGFospropofol8YRG-MRGPRX4-Fospropofol-chim(NtGi1-Gs-CtGq)/β1/γ2
8.82Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
8.82Single9IXXLTD49IXX-CysLT2-LTD4-chim(NtGi1-Gs-CtGq)/β1/γ2
8.82Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
8.82Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
8.57Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
8.57Single2Y02Carmoterol2Y02-β1-Carmoterol
8.57Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
8.57Single6IIVDaltroban6IIV-TXA2-Daltroban
8.57Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
8.57Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
8.57Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
8.57Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
8.57Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
8.57Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
8.57Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
8.57Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
8.57Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
8.57Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
8.57Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
8.57Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
8.57Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
8.57Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
8.57Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
8.57Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
8.57Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
8.57Consensuscck_offOrthosteric Ligandccka_off
8.57Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
8.57Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
8.33Single4NTJAZD12834NTJ-P2Y12-AZD1283
8.33Single5CGCHTL142425CGC-mGlu5-HTL14242
8.33Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
8.33Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
8.33Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
8.33Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
8.33Single7W41PD1762527W41-BB2-PD176252
8.33Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
8.33Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
8.33Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
8.33Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
8.33Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
8.33Single9HAPTolvaptan9HAP-V2-Tolvaptan
8.33Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
8.33Consensusbombesin_offOrthosteric Ligandbb2_off
8.11Single6J20Aprepitant6J20-NK1-Aprepitant
8.11Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
8.11Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
8.11Single8JD5JNJ-40411813; ADX881788JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
8.11Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
8.11Single8XVLZibotentan8XVL-ETA-Zibotentan
8.11Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
8.11Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
8.11Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
8.11Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
8.11Consensustachykinin_offOrthosteric Ligandnk1_off
7.89Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
7.89Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
7.89Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
7.89Single4PY02MeSATP4PY0-P2Y12-2MeSATP
7.89Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
7.89Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
7.89Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.89Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
7.89Single8Y6WTUG-13758Y6W-FFA2-TUG-1375-4-CMTB-Gi1/β1/γ2
7.89Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
7.89Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
7.69Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
7.69Single6K1QIRL25006K1Q-ETB-IRL2500
7.69Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
7.69Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
7.50Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.50Single9JF4PD1683689JF4-BB1-PD168368
7.41Consensusclass-b2_onOrthosteric Ligandadgrg_on adgrf_on adgrl_on adgre_on adgrd_on
7.41Consensusclass-b2_on_gpOrthosteric Ligandadgrg_on_gp adgrf_on_gp adgrl_on_gp adgre_on_gp adgrd_on_gp
7.32Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
7.32Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.32Single8IEBA1LYA8IEB-GPR156-A1LYA
6.90Single5MZPCaffeine5MZP-A2A-Caffeine-Na
6.90Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
6.82Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
6.67Single6VCBLSN31604406VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
6.67Single8HS2Fab0468HS2-GPR20-Fab046
6.45Single3OE8IT1t3OE8-CXCR4-IT1t
6.45Single6TQ9SB-4081246TQ9-OX1-SB-408124
6.45Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
6.45Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Gi1/β1/γ2
6.45Single9IVMLSN33188399IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
6.45Consensusgs_histamineOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
6.45Consensush2_onOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
6.45Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
6.45Consensussensory_onOrthosteric Ligandopsins_on
6.25Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
6.25Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
6.25Single3PQRAll-trans-Retinal3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
6.25Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
6.25Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
6.25Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
6.25Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
6.25Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/β1/γ2
6.25Single7WC5Psilocin7WC5-5-HT2A-Psilocin
6.25Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.25Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
6.25Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
6.25Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
6.25Single8JPSCCL78JPS-ACKR1-CCL7
6.25Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
6.25Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
6.25Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
6.25Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
6.25Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
6.25Consensusgi_sensoryOrthosteric Ligandgi_opsins
6.25Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
6.25Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
6.25Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
6.06Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
6.06Single6HLLCP999946HLL-NK1-CP99994
6.06Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
6.06Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
6.06Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
6.06Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
6.06Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
6.06Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
6.06Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
6.06Single7UL2SR486927UL2-NTS1-SR48692-Na
6.06Single7XP6Strychnine7XP6-TAS2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
6.06Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
6.06Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
6.06Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.06Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
6.06Single8ZYUNeurotensin peptide 8-138ZYU-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
6.06Single9AS7Psilocin9AS7-5-HT2A-Psilocin
6.06Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
6.06Consensusgq_nucleotideOrthosteric Ligandgq_p2y
6.06Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
6.06Consensusneurotensin_offOrthosteric Ligandnts1_off
6.06Consensusnts1_offOrthosteric Ligand7UL2-NTS1-SR48692-Na
5.88Single4XNVBPTU4XNV-P2Y1-BPTU
5.88Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
5.88Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
5.88Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
5.88Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.88Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
5.88Single7XRRLemborexant7XRR-OX2-Lemborexant
5.88Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.88Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.88Single8T3VDocosa-4,7,10,13,16,19-Hexaenoic acid8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.88Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
5.88Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
5.88Single9LRBHistamine9LRB-H1-Histamine-Gs/β1/γ2
5.71Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
5.71Single6TPNHTL66416TPN-OX2-HTL6641
5.71Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
5.71Single8IYXYL-3658IYX-GPR34-YL-365
5.71Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
5.71Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
5.71Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
5.71Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
5.71Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
5.71Single9ARXSerotonin9ARX-5-HT2A-Serotonin
5.71Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.71Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
5.71Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
5.71Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Gi1/β1/γ2
5.56Single7F83PF-051904577F83-Ghrelin-PF-05190457
5.56Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
5.56Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
5.56Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
5.41Single5XPRBosentan5XPR-ETB-Bosentan
5.41Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
5.41Single6HLPNetupitant6HLP-NK1-Netupitant
5.41Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
5.41Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
5.41Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
5.41Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
5.41Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
5.41Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26Single6E59L-7607356E59-NK1-L-760735
5.26Single8JD5JNJ-40411813; ADX881788JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
5.26Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
5.13Single9CM3TUG-13759CM3-FFA2-TUG-1375-Compound 187-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.00Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
5.00Single8T3OTUG-8918T3O-FFA4-TUG-891-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.00Single9JH5C16:0 Ceramide9JH5-CysLT2-C16:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
4.88Single9CM7TUG-13759CM7-FFA2-TUG-1375-AZ-1729-Gi1/β1/γ2
4.88Single9NS9TUG-13759NS9-FFA2-TUG-1375-Compound 187-Gi1/β1/γ2
4.76Single8IEIA1LYA8IEI-GPR156-A1LYA
4.76Single8IEIA1LYA8IEI-GPR156-A1LYA
4.76Single8IEPA1LYA8IEP-GPR156-A1LYA
4.76Single8IEPA1LYA8IEP-GPR156-A1LYA
4.65Single8IEBA1LYA8IEB-GPR156-A1LYA
3.70Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
3.70Single6D35Cholesterol6D35-SMO-Cholesterol
3.70Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
3.70Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
3.70Single6UO8SKF975416UO8-GABAB1, GABAB2-SKF97541-GS39783
3.70Single6UO9SKF975416UO9-GABAB1, GABAB2-SKF97541
3.70Single6W2XPubChem 53110426W2X-GABAB1, GABAB2-PubChem 5311042
3.70Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042
3.70Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042
3.70Single7C7QBaclofen7C7Q-GABAB1, GABAB2-Baclofen-BHFF
3.70Single7C7SCGP546267C7S-GABAB1, GABAB2-CGP54626
3.70Single7CUMCGP546267CUM-GABAB1, GABAB2-CGP54626
3.70Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
3.70Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
3.70Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
3.70Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
3.70Single7DGEQuisqualate7DGE-mGlu1; mGlu1-Quisqualate
3.70Single7DTTCa7DTT-CaS-Ca-Ca
3.70Single7DTTCa7DTT-CaS-Ca-Ca
3.70Single7DTUTryptophan7DTU-CaS-Tryptophan
3.70Single7DTUTryptophan7DTU-CaS-Tryptophan
3.70Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
3.70Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
3.70Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
3.70Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
3.70Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
3.70Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
3.70Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
3.70Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
3.70Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
3.70Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
3.70Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
3.70Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
3.70Single7EB2Baclofen7EB2-GABAB2; GABAB1-Baclofen-rac-BHFF-Gi1/β1/γ2
3.70Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
3.70Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
3.70Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
3.70Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
3.70Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
3.70Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
3.70Single7FIHhCG7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
3.70Single7FIIhCG7FII-LH-hCG-chim(NtGi1-Gs)/β1/γ2
3.70Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
3.70Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
3.70Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
3.70Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
3.70Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
3.70Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
3.70Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
3.70Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
3.70Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
3.70Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
3.70Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
3.70Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
3.70Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
3.70Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
3.70Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
3.70Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
3.70Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
3.70Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
3.70Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
3.70Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
3.70Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
3.70Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
3.70Single7T9NM22 Fab7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
3.70Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
3.70Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
3.70Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
3.70Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
3.70Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
3.70Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
3.70Single7XW6M22 Fab7XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
3.70Single7XW7K1-707XW7-TSH-K1-70
3.70Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
3.70Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
3.70Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
3.70Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
3.70Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
3.70Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
3.70Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
3.70Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
3.70Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
3.70Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
3.70Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
3.70Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
3.70Single8JD0Glutamate8JD0-mGlu2; mGlu3-Glutamate-NAM563
3.70Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
3.70Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
3.70Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
3.70Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
3.70Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
3.70Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
3.70Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
3.70Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
3.70Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
3.70Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
3.70Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
3.70Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
3.70Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
3.70Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
3.70Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
3.70Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
3.70Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
3.70Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
3.70Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
3.70Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
3.70Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
3.70Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
3.70Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
3.70Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
3.70Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
3.70Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
3.70Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
3.70Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
3.70Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
3.70Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
3.70Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
3.70Single8WG9(2S)-2-amino-4-phosphonobutanoic acid8WG9-mGlu4; mGlu2-(2S)-2-amino-4-phosphonobutanoic acid
3.70Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
3.70Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
3.70Single8WGCLY3792688WGC-mGlu4; mGlu2-LY379268
3.70Single8WGDWAG; WA68WGD-mGlu4; mGlu2-WAG; WA6
3.70Single8WGDWAG; WA68WGD-mGlu4; mGlu2-WAG; WA6
3.70Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
3.70Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
3.70Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.70Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.70Single8WVXNorrin8WVX-LGR4-Norrin
3.70Single8WVYNorrin8WVY-LGR4-Norrin
3.70Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
3.70Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
3.70Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
3.70Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
3.70Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
3.70Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
3.70Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
3.70Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
3.70Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
3.70Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
3.70Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
3.70Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
3.70Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
3.70Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
3.70Single8XUMR-spondin-28XUM-LGR4-R-spondin-2
3.70Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
3.70Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
3.70Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
3.70Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
3.70Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
3.70Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
3.70Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
3.70Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
3.70Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
3.70Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
3.70Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
3.70Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
3.70Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
3.70Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
3.70Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
3.70Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
3.70Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
3.70Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
3.70Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
3.70Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
3.70Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
3.70Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
3.70Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
3.70Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
3.70Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
3.70Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
3.70Single9KHHNorrin9KHH-LGR4-Norrin
3.70Single9S37NB219S37-LGR4-NB21
3.70Single9UTBSucralose9UTB-TAS1R2; TAS1R3-Sucralose
3.57Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
3.57Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
3.57Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
3.57Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
3.57Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
3.57Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
3.57Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
3.57Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
3.57Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
3.57Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
3.57Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
3.57Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
3.57Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
3.57Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
3.57Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
3.57Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
3.45Single7KNUCalcitonin gene-related peptide-17KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
3.45Single7T9MCS-17 Antibody7T9M-TSH-CS-17 Antibody
3.45Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
3.45Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
3.33Single4A4MAll-trans-Retinal4A4M-Rhodopsin-All-trans-Retinal-Gt(CT)
3.33Single5EN0All-trans-Retinal5EN0-Rhodopsin-All-trans-Retinal-Gt(CT)
3.33Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
3.33Single7FIGhCG7FIG-LH-hCG-chim(NtGi1L-Gs)/β1/γ2
3.33Single7UTZTR14027UTZ-TSH-TR1402-DPPC-Gs/β1/γ2
3.33Single7XW5TSH7XW5-TSH-TSH-ML109-Gs/β1/γ2
3.33Single7ZI0Cholesterol7ZI0-SMO-SAG-Cholesterol
3.33Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
3.23Single3PXOAll-trans-Retinal3PXO-Rhodopsin-All-trans-Retinal
3.23Single5DYSAll-trans-Retinal5DYS-Rhodopsin-All-trans-Retinal
3.23Single5L7DCholesterol5L7D-SMO-Cholesterol
3.23Single7T9ITSH7T9I-TSH-TSH-Gs/β1/γ2
3.23Single7WC4Serotonin7WC4-5-HT2A-Serotonin
3.23Single8I2GGlycoprotein hormones alpha chain8I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
3.12Single6OY9All-trans-Retinal6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
3.12Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
3.12Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
3.12Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
3.12Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
3.03Single8J6QCompound 9n8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
2.94Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
2.94Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
2.94Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
2.94Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
2.94Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/β1/γ2
2.94Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
2.94Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
2.94Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
2.86Single4K5YCP-3763954K5Y-CRF1-CP-376395
2.86Single6C1QNDT95137276C1Q-C5a1-PMX53-NDT9513727
2.86Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
2.86Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
2.86Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
2.86Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
2.86Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
2.86Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
2.86Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
2.86Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
2.78Single6TPKRetosiban6TPK-OT-Retosiban
2.78Single6ZINSR486926ZIN-NTS1-SR48692
2.78Single7VODCariprazine7VOD-5-HT2A-Cariprazine
2.78Single8JD6VU03647708JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
2.78Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
2.78Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
2.78Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
2.78Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
2.78Consensusvasop-oxy_offOrthosteric Ligandot_off
2.70Single4Z9GCP-3763954Z9G-CRF1-CP-376395
2.70Single8GTIBMK-C2058GTI-CRF1-BMK-C205
2.63Single6Z4SSR486926Z4S-NTS1-SR48692
2.63Single8GTGBMK-I1528GTG-CRF1-BMK-I152
2.56Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Gi1/β1/γ1
2.56Single9CLWTUG-13759CLW-FFA2-TUG-1375-4-CMTB-chim(NtGi1L-Gs-CtGq)/β1/γ2
2.50Single8GTMBMK-C2038GTM-CRF1-BMK-C203
2.33Single8XFTR-spondin-28XFT-LGR4-R-spondin-2-ZNRF3
2.33Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-ZNRF3
2.22Single8WVUR-spondin-18WVU-LGR4-R-spondin-1-RNF43
2.22Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-ZNRF3
2.17Single8XFPR-spondin-28XFP-LGR4-R-spondin-2-ZNRF3
2.04Single8XFSR-spondin-28XFS-LGR4-R-spondin-2-ZNRF3

Consensus Members
Id Members
7S1M 7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
7X8R 7X8R-GLP-1-BOC5-Gs/β1/γ2
6X19 6X19-GLP-1-CHU-128-Gs/β1/γ2
6X1A 6X1A-GLP-1-Danuglipron-Gs/β1/γ2
6X18 6X18-GLP-1-GLP-1-Gs/β1/γ2
8JIP 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
7C2E 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
7KI0 7KI0-GLP-1-Semaglutide-Gs/β1/γ2
7KI1 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
7X8S 7X8S-GLP-1-WB4-24-Gs/β1/γ2
8JIS 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
7VBI 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
Net Summary
Imin 3.19333
Number of Linked Nodes 1143
Number of Links 1253
Number of Hubs 151
Number of Links mediated by Hubs 621
Number of Communities 26
Number of Nodes involved in Communities 182
Number of Links involved in Communities 239
Path Summary
Number Of Nodes in MetaPath 147
Number Of Links MetaPath 146
Number of Shortest Paths 1392647
Length Of Smallest Path 3
Average Path Length 40.3602
Length of Longest Path 102
Minimum Path Strength 0.1925
Average Path Strength 5.62227
Maximum Path Strength 17.1625
Minimum Path Correlation 0.7
Average Path Correlation 0.8409
Maximum Path Correlation 0.993333
Minimum % Of Corr. Nodes 1.04167
Average % Of Corr. Nodes 19.2827
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 38.5445
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following consensuses:
IdComponents
glp_on_gpglp1_on_gp
glp2_on_gp



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