Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
11x39 4.15194407
21x46 4.5125407
31x50 5.86194409
41x60 4.66417406
52x42 6.07978508
62x46 4.52133519
72x50 6.73933519
82x53 3.58833408
92x57 4.46956517
102x60 5.19933516
11E1x50 5.59682718
12E1x52 4.84089516
133x24 4.08806415
143x28 5.62222415
153x32 8.5417
163x43 5.20889419
173x50 7.76583419
183x51 8.26861408
19I2x51 6.71978567
20I2x53 6.620445157
214x50 3.74056619
224x58 5.106674165
23E2 6.57881214
245x39 5.55463617
255x47 8.61426618
265x50 3.08667409
275x54 5.46972418
285x58 5.12944619
295x62 5.268675177
305x81 1.45889401
316x41 2.98156518
326x44 4.56148619
336x48 6.00264818
346x51 6.78944617
356x52 10.5944517
366x55 4.96639416
37E3 4.14762713
387x34 4.67861414
397x38 4.8025416
407x39 7.44644515
417x42 7.18889717
427x49 6.24583419
437x53 5.63622519
448x50 5.29733509
458x54 3.67911507
46G.HN.33 2.63722404
47G.hns1.01 7.038334194
48G.S1.02 7.02533566
49G.S2.02 1.32356505
50G.S2.03 5.286944139
51G.S2.06 5.64694409
52G.S3.03 5.90722668
53G.S3.04 7.54754137
54G.S3.06 8.053054137
55G.s3h2.03 4.77429
56G.H2.06 6.04852629
57G.H2.07 5.89244529
58G.h2s4.01 10.0111409
59G.S4.03 3.99472407
60G.S4.04 4.97409
61G.S4.05 3.39833487
62G.H3.01 3.4413609
63G.H3.03 4.45333404
64G.H3.09 5.02277129
65G.H3.13 9.901785126
66G.H3.17 9.98733525
67G.H3.18 5.40194409
68G.S5.05 4.33756589
69G.S5.07 4.19578589
70G.HG.07 3.47978509
71G.HG.14 3.55333406
72G.HG.16 3.76278404
73G.hgh4.01 5.18444406
74G.hgh4.04 2.91796646
75G.hgh4.05 10.0196506
76G.hgh4.11 3.67222545
77G.hgh4.20 4.68044503
78G.hgh4.21 5.3575404
79G.H4.03 2.98444404
80G.H4.08 5.77089543
81G.H4.10 9.37244547
82G.H4.12 6.244544
83G.H4.13 4.95543
84G.H4.14 6.38361445
85G.H4.15 7.65833408
86G.h4s6.12 5.23333402
87G.S6.02 9.86056408
88G.S6.05 6.81778545
89G.H5.03 3.83056489
90G.H5.05 4.7025465
91G.H5.08 5.94741668
92G.H5.15 3.79444568
93G.H5.17 9.622675185
94G.H5.25 3.36278408
95b.1x1 2.7975404
96b.1x15 4.24806407
97b.b1x6 8.9025439
98b.l1x3 8.30704639
99b.l1x6 11.7728429
100b.b2x1 5.82444428
101b.b2x5 6.3637637
102b.l2x5 10.2578435
103b.b3x3 4.30361408
104b.l3x1 6.71583429
105b.l3x2 7.191394199
106b.b4x6 9.25524739
107b.l4x3 5.32917436
108b.b5x3 5.69333739
109b.b5x5 4.73611405
110b.b5x7 5.22611407
111b.l5x1 4.715785148
112b.l5x5 8.73622509
113b.b6x1 5.09167429
114b.b6x5 4.63333406
115b.b8x4 5.588445146
116b.b9x3 2.79306406
117b.l9x3 7.01022579
118b.l9x6 5.91296628
119b.b10x5 4.76907609
120b.l11x2 7.14911579
121b.b12x6 8.39413778
122b.b13x7 7.85511557
123b.l13x3 7.71093659
124b.l13x6 6.69667429
125b.l13x7 5.08306459
126b.b14x3 4.40861455
127b.b15x1 6.35722659
128b.b15x2 7.40528426
129b.l15x1 5.49133527
130b.l15x2 6.05559
131b.b16x4 8.90083456
132b.b16x5 5.70056405
133b.b16x6 8.56571758
134b.b16x7 7.996394239
135b.b17x5 7.37194427
136b.b17x7 8.51111428
137b.l17x3 8.51381729
138b.l17x6 7.71511529
139b.b18x3 4.96611428
140b.b18x5 5.96333425
141b.l18x1 6.43467106
142b.l18x2 5.534724107
143b.l18x3 8.038064105
144b.b19x2 7.19815626
145b.b19x4 6.28083428
146b.l19x1 6.51694429
147b.l19x2 7.81289529
148b.b20x4 11.0144528
149b.b20x6 6.61413726
150b.b20x7 4.51222409
151b.l20x2 6.79722409
152b.b21x1 7.86956527
153b.b21x5 6.13639404
154b.b21x7 5.99333605
155b.b22x5 5.554816107
156b.l22x5 7.223335209
157b.b23x6 7.13876117
158b.l23x1 6.2725426
159b.l23x2 5.077784118
160b.b24x4 7.931944116
161b.b24x5 3.40056405
162b.b24x6 7.151674118
163b.l24x3 4.486505
164b.l25x3 9.30111499
165b.l25x6 13.0529528
166b.b27x3 5.79722408
167b.l28x1 10.8383729
168b.l28x2 8.34139499
169b.b28x3 4.31333537
170b.b28x4 6.40156596
171b.b28x6 10.4161499
172g.l1x2 3.54861422
173g.l1x4 5.70711528
174g.h2x11 9.237224106
175g.ctx3 5.965936219
176g.ctx6 3.07556406
177g.ctx14 6.40178539
178g.ctx15 7.17306439
179g.ctx16 5.3746738
180Lig 7.077691310
181H.HA.12 1.13083404
182H.HB.13 0.534722403
183H.HC.03 0.786945404
184H.HC.04 1.27403
185H.HC.11 1.51083409
186H.hchd.01 0.3125409
187H.HE.04 0.865278409
188H.hehf.06 0.375409
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
12x57 7x39 11.40314.39556YesYes175
21x43 2x57 15.35084.37222NoYes067
31x43 1x44 15.56180.316667NoNo065
41x44 1x48 15.77350.316667NoNo054
51x48 1x52 15.98572.15333NoNo047
61x52 8x54 16.09246.49333NoYes077
78x50 8x54 16.84983.57333YesYes097
88x50 I1x50 17.62799.33778YesNo099
9I1x49 I1x50 17.86447.57111NoNo069
10I1x49 b.l25x4 18.70374.34NoNo065
11b.l25x4 b.l28x2 19.38555.61667NoYes059
122x46 2x50 15.43044.67556YesYes199
132x46 7x53 16.38653.38889YesYes199
143x50 7x53 46.4056.97111YesYes199
153x50 G.H5.23 76.172814.9756YesNo094
167x42 Lig 17.75823.08333YesYes170
173x36 6x48 15.25123.70667NoYes178
186x44 6x48 46.84545.79111YesYes198
193x43 6x44 29.18433.92222YesYes199
203x36 Lig 10.82726.80889NoYes170
216x48 6x51 20.52973.67556YesYes187
226x51 Lig 10.766512.75YesYes170
236x52 Lig 21.48267.77YesYes170
246x48 6x52 11.06086.34889YesYes187
255x47 6x52 10.982823.6956YesYes187
265x47 6x44 12.49233.33444YesYes189
272x60 3x28 32.51736.44444YesYes165
283x28 E1x50 17.80747.39333YesYes158
29E2 Lig 12.058110.0478YesYes140
305x54 6x44 31.90526.63444YesYes189
315x54 5x58 30.66774.25778YesYes189
32G.H5.22 G.H5.23 76.10545.13444NoNo044
33G.H5.19 G.H5.22 76.16933.29778NoNo084
34G.H5.15 G.H5.19 78.98483.97778YesNo088
35G.H5.15 G.S1.02 78.76274.56778YesYes686
36G.S1.02 G.S3.03 79.14845.53222YesYes668
37G.S1.04 G.S3.03 80.46525.54778NoYes078
38G.S1.04 G.S4.03 80.54344.75778NoYes077
39G.H5.07 G.S4.03 81.59953.81222NoYes097
40G.H5.07 G.S5.05 81.68233.83222NoYes099
41G.S4.05 G.S5.05 46.08723.20222YesYes879
42G.S4.05 G.S5.07 46.22633.94222YesYes879
43G.S5.07 G.s5hg.01 92.69466.06333YesNo099
44G.HG.03 G.s5hg.01 92.8446.11NoNo069
45G.HG.03 G.s4h3.02 92.89923.66889NoNo069
46G.HG.07 G.s4h3.02 92.91813.4YesNo099
47G.HG.07 G.s4h3.04 89.55296.10444YesNo098
48G.S5.05 G.s6h5.01 46.0036.48556YesNo899
49G.S5.07 G.s6h5.01 46.38075.84889YesNo899
50b.l25x3 b.l28x2 19.55165.88222YesYes999
51b.b27x3 b.l25x3 13.24397.75778YesYes089
52b.b25x7 b.b28x6 14.160917.5889NoYes079
53b.b25x7 b.lhb1x11 21.38454.71111NoNo074
54b.lhb1x11 g.ctx5 21.4123.76667NoNo049
55g.ctx3 g.ctx5 21.39074.22444YesNo2199
56g.ctx3 g.ctx4 21.8174.83YesNo097
57b.l27x5 g.ctx4 21.83334.84333NoNo057
58b.l27x5 g.ctx15 12.27246.33444NoYes059
59b.b28x5 g.ctx16 11.08444.46444NoYes358
60b.b1x6 b.b28x5 11.10653.33YesNo395
61b.b1x6 b.b4x6 11.041621.0067YesYes399
62b.b4x6 b.l1x3 19.92315.52444YesYes399
63b.b3x6 b.l1x3 20.06259.91778NoYes099
64b.b3x6 b.l3x2 20.03999.32556NoYes099
65G.hns1.01 b.l3x2 22.88133.32222YesYes1949
66G.S1.03 G.hns1.01 23.048416.12NoYes094
67G.S1.03 G.h2s4.03 23.0533.17667NoNo096
68G.h2s4.03 b.l3x1 19.53484.64222NoYes269
69G.hgh4.01 G.s4h3.04 86.3143.2YesNo068
70G.hgh4.01 G.s4h3.15 86.38310.5956YesNo069
71G.H3.03 G.s4h3.15 86.38693.08YesNo049
72G.H3.03 G.H3.06 86.48675.17444YesNo046
73G.H3.06 G.H4.15 88.17558.52778NoYes068
74G.H4.15 G.S4.06 45.01786.11667YesNo087
75G.S4.04 G.S4.06 45.01044.36889YesNo097
76G.H3.09 G.H4.15 45.36.78667YesYes098
77G.H3.09 G.S4.04 45.25955.24YesYes099
78G.H3.08 G.S4.04 90.16416.21NoYes089
79G.H2.04 G.H3.08 90.08566.99444NoNo098
80G.H2.04 G.H2.07 90.01827.66667NoYes099
81b.b2x1 b.l3x1 17.10315.88556YesYes289
82b.b2x1 b.b6x1 23.22116.65222YesYes289
83b.b6x1 b.l9x6 23.35196.65111YesYes298
84G.H2.07 b.l9x6 86.90344.50222YesYes298
85G.H2.06 b.l9x6 1003.71556YesYes298
86G.H2.06 b.l17x6 49.85657.68444YesYes299
87G.H2.06 b.l19x1 49.7784.76222YesYes299
88G.H5.10 G.S6.02 10.130111.2378NoYes078
89G.H5.10 G.S6.04 10.358112.1867NoNo079
90G.S5.05 G.S6.04 10.48254.27444YesNo099
91b.l17x5 b.l17x6 49.78073.92778NoYes269
92b.l17x5 b.l19x2 99.353.26889NoYes269
93b.l17x3 b.l19x2 98.10845.18111YesYes299
94b.b20x6 b.l17x3 94.68673.26889YesYes269
95b.b17x7 b.b20x6 91.623612.1467YesYes286
96b.b17x7 b.b21x1 89.3294.38YesYes287
97b.1x19 b.b21x1 44.55938.33778NoYes067
98b.1x15 b.1x19 43.94266.96111YesNo076
99b.1x15 g.h1x15 11.7512.52556YesNo078
100b.1x14 g.h1x15 11.11371.68556NoNo048
101b.1x11 b.1x14 10.47631.92111NoNo084
102b.l17x5 b.l19x1 49.71834.90778NoYes269
103b.b21x1 g.l1x4 44.401410.3222YesYes278
104b.1x15 g.l1x4 43.9944.31667YesYes078
105b.1x15 g.h1x14 76.08793.18889YesNo079
106b.b17x6 g.h1x14 39.78587.05667NoNo079
107b.b16x4 b.b17x6 39.47111.1789YesNo067
108b.b16x4 b.b16x6 35.35917.60444YesYes568
109b.b15x1 b.b16x6 10.115511.5822YesYes598
110g.h1x10 g.h1x14 35.98895.94667NoNo099
111b.b17x3 g.h1x10 35.67435.25556NoNo059
112b.b16x6 b.b17x3 35.35957.83667YesNo585
113b.b13x7 b.b16x6 58.718716.9289YesYes578
114b.b13x5 b.b13x7 56.83695.33333NoYes047
115b.b12x5 b.b13x5 56.20493.92889NoNo064
116b.b12x5 b.b13x4 53.04944.25778NoNo064
117b.b12x7 b.b13x4 52.41723.21333NoNo094
118b.b12x7 b.l12x3 50.53058.35111NoNo095
119b.b13x1 b.l12x3 48.65022.42667NoNo045
120b.b13x1 b.b9x2 48.01772.16667NoNo045
121H.HB.14 b.b9x2 47.38410.535556NoNo015
122H.HB.13 H.HB.14 46.76880.311111YesNo031
123H.HA.16 H.HB.13 41.23040.16NoYes043
124H.HA.16 H.HC.03 38.76881.10333NoYes044
125H.HC.03 H.HC.07 26.46130.307778YesNo046
126H.HC.07 H.HC.11 25.84590.287778NoYes069
127H.HC.08 H.HC.11 23.38440.515556NoYes039
128H.HC.08 H.HE.09 22.15360.323333NoNo034
129H.HC.04 H.HE.09 21.53820.94YesNo034
130H.HC.04 H.hbhc.14 20.30750.802222YesNo034
131H.HA.12 H.hbhc.14 19.69212.06778YesNo044
132H.HA.09 H.HA.12 17.8460.452222NoYes034
133H.HA.06 H.HA.09 16.61520.157778NoNo033
134H.HA.06 H.HA.07 15.99980.166667NoNo035
135H.HA.07 H.HF.04 13.53830.156667NoNo057
136H.HF.04 H.hehf.06 12.92290.73NoYes079
1372x57 7x42 11.25765.68778YesYes177
1382x60 7x42 29.33265.8YesYes167
1393x50 5x58 30.28984.80111YesYes199
1403x43 7x53 29.59465.73111YesYes199
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
2x563x327.301111NoYes8721
2x567x425.311111NoYes8721
2x577x394.395561YesYes7522
2x577x425.687781YesYes7721
2x607x395.542221YesYes6522
2x607x425.81YesYes6721
3x26E23.787781NoYes6421
3x323x363.273331YesNo7711
3x327x4211.291YesYes7711
3x32Lig12.13561YesYes7010
3x334x574.302220NoNo6712
3x335x394.968890NoYes6712
3x33Lig10.20NoYes6010
3x366x483.706671NoYes7812
3x36Lig6.808891NoYes7010
3x375x4617.106670NoNo6621
4x60E23.903331NoYes6421
4x605x397.881111NoYes6722
4x61E28.148891NoYes5421
4x63E29.110NoYes4421
E2E29.854441YesYes4411
5x39E27.231111YesYes7421
E2E2x517.913331YesNo4512
6x55E23.062221YesYes6411
E2Lig10.04781YesYes4010
5x395x4310.31561YesNo7721
5x43Lig7.824450NoYes7010
5x446x525.868890NoYes7721
5x446x554.138890NoYes7621
5x461Lig4.237780NoYes6010
5x476x483.118891YesYes8822
5x476x5223.69561YesYes8721
6x486x513.675561YesYes8721
6x486x526.348891YesYes8721
6x516x529.288891YesYes7711
6x516x555.772221YesYes7611
6x517x344.883331YesYes7412
6x517x384.366671YesYes7611
6x51Lig12.751YesYes7010
6x52Lig7.771YesYes7010
6x55Lig6.892221YesYes6010
7x347x383.785561YesYes4621
7x387x427.902221YesYes6711
7x397x4211.24781YesYes5721
7x42Lig3.083331YesYes7010
3x29Lig3.475560NoYes5010
4x64E23.578890NoYes5421
E2x52Lig3.628890NoYes5010
7x38Lig3.155561YesYes6010
5x40E22.453330NoYes5421

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
92.31Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRR-D1-Rotigotine-Gs/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
85.71Single6H7JIsoprenaline6H7J-β1-Isoprenaline
85.71Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
85.71Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2
85.71Single7JVPSKF839597JVP-D1-SKF83959-Gs/&β;1/&γ;2
84.62Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
84.62Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
84.62Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
84.62Single8GE3Epinephrine8GE3-β2-Epinephrine-Gs/&β;1/&γ;2
84.62Single8GEEEpinephrine8GEE-β2-Epinephrine-Gs/&β;1/&γ;2
84.62Single8GFWEpinephrine8GFW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
84.62Single8GFXEpinephrine8GFX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
84.62Single8GFYEpinephrine8GFY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
84.62Single8GFZEpinephrine8GFZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
84.62Single8GG0Epinephrine8GG0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
84.62Single8GG1Epinephrine8GG1-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
84.62Single8GG2Epinephrine8GG2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
84.62Single8GG6Epinephrine8GG6-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
84.62Single8GGJEpinephrine8GGJ-β2-Epinephrine
84.62Single8GGNEpinephrine8GGN-β2-Epinephrine
84.62Single8GGOEpinephrine8GGO-β2-Epinephrine
84.62Single8GGUEpinephrine8GGU-β2-Epinephrine
84.62Single8UNNEpinephrine8UNN-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
84.62Single8UNPEpinephrine8UNP-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
84.62Consensusadrenergic_onOrthosteric Ligandbeta_on alpha_on
84.62Consensusdopamine_onOrthosteric Ligandd3_on d2_on d5_on d1_on
80.00Single4LDEBI1671074LDE-β2-BI167107
80.00Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
78.57Single2RH1(S)-Carazolol2RH1-β2-(S)-Carazolol
78.57Single2Y03Isoprenaline2Y03-β1-Isoprenaline
78.57Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
78.57Single6PS3(S)-Carvedilol6PS3-β2-(S)-Carvedilol
78.57Single7BVQ(S)-Carazolol7BVQ-β1-(S)-Carazolol
78.57Single7CKXA776367CKX-D1-A77636-Gs/&β;1/&γ;2
78.57Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2
78.57Single7XKAEpinephrine7XKA-β2-Epinephrine
78.57Single8UNYEpinephrine8UNY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
78.57Consensusadrenergic_offOrthosteric Ligandbeta_off alpha_off
78.57Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
78.57Consensusamine_offOrthosteric Ligandadrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
78.57Consensusbeta2_offOrthosteric Ligand6PS2-β2-(S)-Alprenolol 6PS3-β2-(S)-Carvedilol 6PS5-β2-(S)-Propranolol 6PS6-β2-Timolol 2RH1-β2-(S)-Carazolol 6PS4-β2-ICI 118-551 3NY9-β2-PubChem 913103
78.57Consensusbeta2_onOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
78.57Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
78.57Consensusgi_adrenergicOrthosteric Ligand7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
78.57Consensusgs_adrenergicOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJI-β3-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
78.57Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
76.92Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
76.92Single6PS4ICI 118-5516PS4-β2-ICI 118-551
76.92Single6PS5(S)-Propranolol6PS5-β2-(S)-Propranolol
76.92Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
76.92Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
76.92Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
76.92Single7JOZVFP7JOZ-D1-VFP-Gs/&β;1/&γ;2
76.92Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
76.92Single8GE1Epinephrine8GE1-β2-Epinephrine-Gs/&β;1/&γ;2
76.92Single8GE4Epinephrine8GE4-β2-Epinephrine-Gs/&β;1/&γ;2
76.92Single8GE6Epinephrine8GE6-β2-Epinephrine-Gs/&β;1/&γ;2
76.92Single8GE7Epinephrine8GE7-β2-Epinephrine-Gs/&β;1/&γ;2
76.92Single8GE8Epinephrine8GE8-β2-Epinephrine-Gs/&β;1/&γ;2
76.92Single8GE9Epinephrine8GE9-β2-Epinephrine-Gs/&β;1/&γ;2
76.92Single8GEGEpinephrine8GEG-β2-Epinephrine-Gs/&β;1/&γ;2
76.92Single8GFVEpinephrine8GFV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
76.92Single8GG3Epinephrine8GG3-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
76.92Single8GG4Epinephrine8GG4-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
76.92Single8GG5Epinephrine8GG5-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
76.92Single8GGIEpinephrine8GGI-β2-Epinephrine
76.92Single8GGKEpinephrine8GGK-β2-Epinephrine
76.92Single8GGMEpinephrine8GGM-β2-Epinephrine
76.92Single8GGPEpinephrine8GGP-β2-Epinephrine
76.92Single8GGQEpinephrine8GGQ-β2-Epinephrine
76.92Single8UNQEpinephrine8UNQ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
76.92Single8UNREpinephrine8UNR-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
76.92Single8UNSEpinephrine8UNS-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
76.92Single8UNZEpinephrine8UNZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
76.92Consensusd1_on_alloOrthosteric Ligand7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
76.92Consensusd3_onOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
75.00Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
75.00Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
75.00Consensusbeta1_off_alloOrthosteric Ligand4BVN-β1-Cyanopindolol-Na
73.33Single2YDVNECA2YDV-A2A-NECA
73.33Single3SN6BI1671073SN6-β2-BI167107-Gs/&β;1/&γ;2
73.33Single4UHRCGS216804UHR-A2A-CGS21680
73.33Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
73.33Single5D5A(S)-Carazolol5D5A-β2-(S)-Carazolol
73.33Single5D5B(S)-Carazolol5D5B-β2-(S)-Carazolol
73.33Single5G53NECA5G53-A2A-NECA-Gs
73.33Single7JV5SKF812977JV5-D1-SKF81297-Gs/&β;1/&γ;2
73.33Single7W6PW967W6P-α2a-W96-Go/&β;1/&γ;2
73.33Single7W7EW587W7E-α2a-W58-Go/&β;1/&γ;2
73.33Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/&β;1/&γ;2
73.33Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/&β;1/&γ;2
73.33Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
73.33Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCZ-β1-Iodocyanopindolol
73.33Consensusgi_amineOrthosteric Ligandgi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
73.33Consensusgi_dopamineOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
71.43Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
71.43Single2Y04Salbutamol2Y04-β1-Salbutamol
71.43Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
71.43Single3NY8ICI 118-5513NY8-β2-ICI 118-551
71.43Single3NYA(S)-Alprenolol3NYA-β2-(S)-Alprenolol
71.43Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
71.43Single4GBR(S)-Carazolol4GBR-β2-(S)-Carazolol
71.43Single5JQH(S)-Carazolol5JQH-β2-(S)-Carazolol
71.43Single6H7MSalbutamol6H7M-β1-Salbutamol
71.43Single6PRZ(S)-Alprenolol6PRZ-β2-(S)-Alprenolol
71.43Single6PS0(S)-Carazolol6PS0-β2-(S)-Carazolol
71.43Single6PS1Timolol6PS1-β2-Timolol
71.43Single6PS2(S)-Alprenolol6PS2-β2-(S)-Alprenolol
71.43Single7CRHSKF839597CRH-D1-SKF83959-Gs/&β;1/&γ;2
71.43Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
71.43Single7LJCPubChem 867641037LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
71.43Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
71.43Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
71.43Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
71.43Single8GEBEpinephrine8GEB-β2-Epinephrine-Gs/&β;1/&γ;2
71.43Single8GEHEpinephrine8GEH-β2-Epinephrine-Gs/&β;1/&γ;2
71.43Single8GGBEpinephrine8GGB-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
71.43Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2
71.43Single8JJOAlprenolol8JJO-β2-Alprenolol
71.43Single8UNMEpinephrine8UNM-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
71.43Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
71.43Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
71.43Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
71.43Consensusalpha2_onOrthosteric Ligandalpha2a_on alpha2b_on
71.43Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
71.43Consensusamine_onOrthosteric Ligandadrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on
71.43Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
71.43Consensusgi_5htOrthosteric Ligand7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
71.43Consensustar_onOrthosteric Ligandta1_on
70.59Single3NY9PubChem 9131033NY9-β2-PubChem 913103
70.59Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
69.23Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2
69.23Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/&β;1/&γ;2
69.23Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
69.23Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2
69.23Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
69.23Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2
69.23Single8GEAEpinephrine8GEA-β2-Epinephrine-Gs/&β;1/&γ;2
69.23Single8GECEpinephrine8GEC-β2-Epinephrine-Gs/&β;1/&γ;2
69.23Single8GEDEpinephrine8GED-β2-Epinephrine-Gs/&β;1/&γ;2
69.23Single8GEFEpinephrine8GEF-β2-Epinephrine-Gs/&β;1/&γ;2
69.23Single8GG7Epinephrine8GG7-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
69.23Single8GG9Epinephrine8GG9-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
69.23Single8GGAEpinephrine8GGA-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
69.23Single8GGVEpinephrine8GGV-β2-Epinephrine
69.23Single8GGWEpinephrine8GGW-β2-Epinephrine
69.23Single8GGXEpinephrine8GGX-β2-Epinephrine
69.23Single8GH0Epinephrine8GH0-β2-Epinephrine
69.23Single8UNLEpinephrine8UNL-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
69.23Single8UNOEpinephrine8UNO-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
69.23Single8UNTEpinephrine8UNT-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
69.23Single8UNUEpinephrine8UNU-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
69.23Single8UNWEpinephrine8UNW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
69.23Single8UO0Epinephrine8UO0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
69.23Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
69.23Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
69.23Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
69.23Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
69.23Consensusgi_nucleotideOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
68.75Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
68.75Single3D4STimolol Maleate3D4S-β2-Timolol Maleate
68.75Single4AMIBucindolol4AMI-β1-Bucindolol
68.75Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
68.75Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
68.75Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
68.75Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
68.75Single8JJ8Formoterol8JJ8-β2-Formoterol
68.75Consensusopioid_offOrthosteric Ligandkop_off mop_off nop_off dop_off
66.67Single2YCW(S)-Carazolol2YCW-β1-(S)-Carazolol
66.67Single5D6L(S)-Carazolol5D6L-β2-(S)-Carazolol
66.67Single5X7D(S)-Carazolol5X7D-β2-(S)-Carazolol-PubChem 129318963
66.67Single6E67BI1671076E67-β2-BI167107-Gs (fused)
66.67Single7WC6LSD7WC6-5-HT2A-LSD
66.67Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
66.67Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
66.67Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
66.67Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
66.67Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
64.71Single6H7LDobutamine6H7L-β1-Dobutamine
64.71Single6IBLArformoterol6IBL-β1-Arformoterol
64.71Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/&β;1/&γ;2
64.71Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
64.71Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
64.29Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
64.29Single6TPGEMPA6TPG-OX2-EMPA
64.29Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/&β;1/&γ;2
64.29Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
64.29Single7F0TDopamine7F0T-D1-Dopamine-Gs/&β;1/&γ;2
64.29Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/&β;1/&γ;2
64.29Single8GDZEpinephrine8GDZ-β2-Epinephrine-Gs/&β;1/&γ;2
64.29Single8GG8Epinephrine8GG8-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
64.29Single8GGLEpinephrine8GGL-β2-Epinephrine
64.29Single8GGTEpinephrine8GGT-β2-Epinephrine
64.29Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
64.29Single8JLNT1AM8JLN-TA1-T1AM-Gs/&β;1/&γ;2
64.29Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
64.29Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
64.29Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
64.29Single8UHBRO52563908UHB-TA1-RO5256390-Gs/&β;1/&γ;2
64.29Single8UO2Epinephrine8UO2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
64.29Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/&β;1/&γ;2
64.29Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
64.29Consensusalpha2b_onOrthosteric Ligand6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
64.29Consensusgs_tarOrthosteric Ligand8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
62.50Single3P0GBI1671073P0G-β2-BI167107
62.50Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
62.50Single4RWADIPP-NH24RWA-δ-DIPP-NH2
62.50Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
62.50Single6J21Aprepitant6J21-NK1-Aprepitant
62.50Single6TQ7SB-3348676TQ7-OX1-SB-334867
62.50Single6WGTLSD6WGT-5-HT2A-LSD
62.50Single7CKYPW04647CKY-D1-PW0464-Gs/&β;1/&γ;2
62.50Single8E0GBU728E0G-μ-BU72
62.50Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
62.50Consensus5ht5_offOrthosteric Ligand5ht5a_off
62.50Consensus5ht_offOrthosteric Ligand5ht2_off 5ht5_off 5ht1_off
62.50Consensusa2_onOrthosteric Liganda2a_on a2b_on
62.50Consensusdopamine_offOrthosteric Ligandd3_off d2_off d4_off
62.50Consensusgo_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
62.50Consensush1_offOrthosteric Ligand3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole 8X63-H1-Mepyramine 8X64-H1-Desloratadine
62.50Consensushistamine_offOrthosteric Ligandh1_off
61.54Single3PBLEticlopride3PBL-D3-Eticlopride
61.54Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
61.54Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/&β;1/&γ;2
61.54Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2
61.54Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2
61.54Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/&β;1/&γ;2
61.54Single8GEIEpinephrine8GEI-β2-Epinephrine-Gs/&β;1/&γ;2
61.54Single8GGSEpinephrine8GGS-β2-Epinephrine
61.54Single8GGYEpinephrine8GGY-β2-Epinephrine
61.54Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
61.54Single8UNVEpinephrine8UNV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
61.54Single8UNXEpinephrine8UNX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
61.54Consensus5ht4_onOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
61.54Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
61.11Single4UG2CGS216804UG2-A2A-CGS21680
60.00Single2Y02Carmoterol2Y02-β1-Carmoterol
60.00Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
60.00Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
60.00Single4QKXPubChem 762106284QKX-β2-PubChem 76210628
60.00Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
60.00Single7BU7BI1671077BU7-β1-BI167107
60.00Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/&β;1/&γ;2
60.00Single7UL4Alvimopan7UL4-μ-Alvimopan
60.00Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2
60.00Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
60.00Single7WC7Lisuride7WC7-5-HT2A-Lisuride
60.00Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
60.00Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2
60.00Single8JLZST19368JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
60.00Single8UO4Epinephrine8UO4-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
60.00Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/&β;1/&γ;2
60.00Single8X64Desloratadine8X64-H1-Desloratadine
60.00Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
60.00Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
58.82Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
58.82Single6H7N(S)-Xamoterol6H7N-β1-(S)-Xamoterol
58.82Single6MXTSalmeterol6MXT-β2-Salmeterol
58.82Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
58.82Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/&β;1/&γ;2
58.82Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
58.82Single7YITNalfurafine7YIT-κ-Nalfurafine
58.82Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
58.82Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
58.82Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
58.82Consensusbeta1_onOrthosteric Ligand7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
58.82Consensusgo_5htOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
58.82Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
57.89Single4AMJ(S)-Carvedilol4AMJ-β1-(S)-Carvedilol
57.89Single4IARErgotamine4IAR-5-HT1B-Ergotamine
57.89Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
57.89Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
57.89Consensusmop_offOrthosteric Ligand7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
57.14Single6KUXRS-799486KUX-α2a-RS-79948
57.14Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
57.14Single6OBA(S)-Alprenolol6OBA-β2-(S)-Alprenolol-GTPL11074
57.14Single6TODEMPA6TOD-OX1-EMPA-Na
57.14Single7C61Ergotamine7C61-5-HT1B-Ergotamine
57.14Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
57.14Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;1
57.14Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
57.14Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
57.14Single8EFOPZM218EFO-μ-PZM21-Gi1/&β;1/&γ;2
57.14Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/&β;1/&γ;2
57.14Single8UO1Epinephrine8UO1-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
57.14Single8UO3Epinephrine8UO3-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
57.14Consensus5ht2_onOrthosteric Ligand5ht2a_on 5ht2c_on
57.14Consensusalpha1_onOrthosteric Ligandalpha1a_on
57.14Consensusalpha1a_onOrthosteric Ligand7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
57.14Consensusalpha2_offOrthosteric Ligandalpha2a_off alpha2c_off
57.14Consensusalpha2a_offOrthosteric Ligand6KUX-α2a-RS-79948
57.14Consensusbeta2_off_alloOrthosteric Ligand6OBA-β2-(S)-Alprenolol-GTPL11074
57.14Consensusgs_5htOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2 7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2 7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
56.25Single5C1MBU725C1M-μ-BU72
56.25Single5TVNLSD5TVN-5-HT2B-LSD
56.25Single5WIUNemonapride5WIU-D4-Nemonapride
56.25Single5WIVNemonapride5WIV-D4-Nemonapride-Na
56.25Single5WQCEMPA5WQC-OX2-EMPA
56.25Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
56.25Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
56.25Single6PS6Timolol6PS6-β2-Timolol
56.25Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
56.25Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
56.25Single7SBFPZM217SBF-μ-PZM21-Gi1/&β;1/&γ;2
56.25Single8DZQmomSalB8DZQ-κ-momSalB-Go/&β;1/&γ;2
56.25Consensusa1_on_alloOrthosteric Ligand7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
56.25Consensusalpha2a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
56.25Consensusd4_offOrthosteric Ligand5WIU-D4-Nemonapride
56.25Consensusd4_off_alloOrthosteric Ligand5WIV-D4-Nemonapride-Na
56.25Consensusgo_amineOrthosteric Ligandgo_adrenergic go_muscarinic go_5ht
56.25Consensusgo_opioidOrthosteric Ligand8DZQ-κ-momSalB-Go/&β;1/&γ;2
55.56Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
55.56Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
55.56Single7UM4AS26747237UM4-5-HT5A-AS2674723
55.56Single7XJISolabegron7XJI-β3-Solabegron-Gs/&β;1/&γ;2
55.56Single8E9YPubChem 4466038E9Y-M3-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
55.56Consensus5ht5a_offOrthosteric Ligand7UM4-5-HT5A-AS2674723
55.56Consensusendothelin_offOrthosteric Ligandetb_off
55.56Consensusetb_offOrthosteric Ligand5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500 5X93-ETB-K-8794
55.56Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
55.00Single6HLOAprepitant6HLO-NK1-Aprepitant
55.00Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
53.85Single8GGREpinephrine8GGR-β2-Epinephrine
53.85Single8GGZEpinephrine8GGZ-β2-Epinephrine
53.85Single8J6QBeta-hydroxybutyrate8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
53.85Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
53.85Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
53.33Single2YDOAdenosine2YDO-A2A-Adenosine
53.33Single4ZJCSB-6740424ZJC-OX1-SB-674042
53.33Single6A94Zotepine6A94-5-HT2A-Zotepine
53.33Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
53.33Single6TPNHTL66416TPN-OX2-HTL6641
53.33Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
53.33Single7CMVPD1289077CMV-D3-PD128907-Gi1/&β;1/&γ;2
53.33Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2
53.33Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
53.33Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
53.33Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2
53.33Consensus5ht2a_onOrthosteric Ligand7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
53.33Consensus5ht5_onOrthosteric Ligand5ht5a_on
53.33Consensus5ht5a_onOrthosteric Ligand7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
53.33Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
53.33Consensusox1_offOrthosteric Ligand6TOT-OX1-Lemborexant 6TP4-OX1-ACT-462206 6TP6-OX1-Filorexant 6V9S-OX1-GTPL11403 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ7-OX1-SB-334867 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant
53.33Consensusox2_offOrthosteric Ligand6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant
52.94Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
52.94Single4U15Tiotropium4U15-M3-Tiotropium
52.94Single5X93K-87945X93-ETB-K-8794
52.94Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
52.94Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
52.94Single6J20Aprepitant6J20-NK1-Aprepitant
52.94Single6NI3BI1671076NI3-β2-BI167107-Gs/&β;1/&γ;2
52.94Single6OL9Tiotropium6OL9-M5-Tiotropium
52.94Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2
52.94Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
52.94Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2
52.94Single8DZPmomSalB8DZP-κ-momSalB-Gi1/&β;1/&γ;2
52.94Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
52.94Single8JXVClozapine8JXV-H4-Clozapine-Gi1/&β;1/&γ;2
52.94Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
52.94Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A2A-NECA-Gs/&β;1/&γ;1 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
52.94Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
52.94Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
52.94Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
52.94Consensusnk1_offOrthosteric Ligand6J20-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
52.63Single8X5YAstemizole8X5Y-H1-Astemizole
52.63Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
50.00Single2Y01Dobutamine2Y01-β1-Dobutamine
50.00Single4EJ4Naltrindole4EJ4-δ-Naltrindole
50.00Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
50.00Single4U16N-Methyl Scopolamine4U16-M3-N-Methyl Scopolamine
50.00Single4X1HNonyl Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
50.00Single5CXVTiotropium5CXV-M1-Tiotropium
50.00Single5DHGPubChem 250014125DHG-NOP-PubChem 25001412
50.00Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
50.00Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
50.00Single5YC8N-Methyl Scopolamine5YC8-M2-N-Methyl Scopolamine
50.00Single5ZK8N-Methyl Scopolamine5ZK8-M2-N-Methyl Scopolamine
50.00Single5ZKCN-Methyl Scopolamine5ZKC-M2-N-Methyl Scopolamine
50.00Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
50.00Single6HLPNetupitant6HLP-NK1-Netupitant
50.00Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
50.00Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
50.00Single6TOTLemborexant6TOT-OX1-Lemborexant
50.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
50.00Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2
50.00Single7SRQLSD7SRQ-5-HT2B-LSD
50.00Single7T2GMitragynine pseudoindoxyl7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
50.00Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/&β;1/&γ;2
50.00Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
50.00Single7XMTJ-21567XMT-SST4-J-2156-Gi1/&β;1/&γ;2
50.00Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
50.00Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
50.00Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
50.00Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
50.00Single8EF6Morphine8EF6-μ-Morphine-Gi1/&β;1/&γ;2
50.00Single8G59TUG-8918G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
50.00Single8GGCEpinephrine8GGC-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
50.00Single8GGEEpinephrine8GGE-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
50.00Single8GH1Epinephrine8GH1-β2-Epinephrine
50.00Single8I95EP548I95-C3aB-EP54-Go/&β;1/&γ;2
50.00Single8IJDMK68928IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
50.00Single8JJLOlodaterol8JJL-β2-Olodaterol
50.00Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
50.00Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
50.00Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
50.00Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/&β;1/&γ;2
50.00Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
50.00Single8X63Mepyramine8X63-H1-Mepyramine
50.00Consensus5ht1a_onOrthosteric Ligand8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
50.00Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
50.00Consensusadenosine_onOrthosteric Liganda1_on a2_on
50.00Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
50.00Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
50.00Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
50.00Consensusgi_hcaOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
50.00Consensusgi_hcarOrthosteric Ligandgi_hca
50.00Consensusgo_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
50.00Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
50.00Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
50.00Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
50.00Consensushca2_onOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
50.00Consensushistamine_onOrthosteric Ligandh1_on h4_on
50.00Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
50.00Consensusnucleotide_onOrthosteric Ligandadenosine_on
50.00Consensusox1_off_alloOrthosteric Ligand6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na 6TO7-OX1-Suvorexant-Na
47.83Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
47.62Single3QAKUK-4320973QAK-A2A-UK-432097
47.62Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
47.37Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
47.37Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
47.37Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
47.37Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
47.37Single6DDFDamgo6DDF-μ-Damgo-Gi1/&β;1/&γ;2
47.37Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
47.37Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
47.37Single7EZCUKA7EZC-A2A-UKA
47.37Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
47.37Single7XK2MK68927XK2-HCA2-MK6892-Gi1/&β;1/&γ;2
47.37Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
47.37Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
47.37Consensusffa4_on_alloOrthosteric Ligand8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
47.06Single2Y00Dobutamine2Y00-β1-Dobutamine
47.06Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
47.06Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
47.06Single5XPRBosentan5XPR-ETB-Bosentan
47.06Single5ZK3Quinuclidinyl benzilate hydrobromide5ZK3-M2-Quinuclidinyl benzilate hydrobromide
47.06Single6DDEDamgo6DDE-μ-Damgo-Gi1/&β;1/&γ;2
47.06Single6GDGNECA6GDG-A2A-NECA-Gs/&β;1/&γ;1
47.06Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
47.06Single6TP6Filorexant6TP6-OX1-Filorexant
47.06Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
47.06Single7CFNINT-7777CFN-GPBA-INT-777-Gs/&β;1/&γ;2
47.06Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
47.06Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
47.06Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
47.06Single8J19PubChem 1270454228J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
47.06Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
47.06Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
47.06Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
47.06Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide 6DRX-5-HT2B-Lisuride
47.06Consensusa2a_onOrthosteric Ligand6GDG-A2A-NECA-Gs/&β;1/&γ;1
47.06Consensusgs_muscarinicOrthosteric Ligand8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
47.06Consensusm2_offOrthosteric Ligand5ZKB-M2-AF-DX 384 5ZKC-M2-N-Methyl Scopolamine 5ZK3-M2-Quinuclidinyl benzilate hydrobromide
47.06Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
46.67Single2X72All-trans-retinal2X72-Rhodopsin-All-trans-retinal-Gt(CT)
46.67Single3VGAZM2413853VGA-A2A-ZM241385-Antibody
46.67Single5WS3EMPA5WS3-OX2-EMPA
46.67Single6AKXA4R6AKX-CCR5-A4R
46.67Single6B73PubChem 1319551386B73-κ-PubChem 131955138
46.67Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/&β;1/&γ;2
46.67Single6ME2Ramelteon6ME2-MT1-Ramelteon
46.67Single6NWEOctyl Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
46.67Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
46.67Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2
46.67Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
46.67Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
46.67Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2
46.67Single8GGFEpinephrine8GGF-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
46.67Single8IW4Spermidine8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2
46.67Single8IWESpermidine8IWE-TAAR9-Spermidine
46.67Consensus5ht2c_onOrthosteric Ligand8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
46.67Consensusorexin_offOrthosteric Ligandox2_off ox1_off
46.15Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
46.15Consensushca2_on_alloOrthosteric Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
45.83Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
45.45Single5WF5UK-4320975WF5-A2A-UK-432097
45.45Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
45.45Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
45.00Single5WF6UK-4320975WF6-A2A-UK-432097
45.00Single5ZTYAM102575ZTY-CB2-AM10257
45.00Single6PT3DPI-2876PT3-δ-DPI-287
45.00Single7XY6PubChem 117178317XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
45.00Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
45.00Single8IYHMK68928IYH-HCA2-MK6892-Go/&β;1/&γ;2
45.00Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
45.00Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
45.00Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
45.00Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
44.44Single3UONQuinuclidinyl benzilate hydrobromide3UON-M2-Quinuclidinyl benzilate hydrobromide
44.44Single4DJHJDTic4DJH-κ-JDTic
44.44Single5V54Methiothepin5V54-5-HT1B-Methiothepin
44.44Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
44.44Single6E59L-7607356E59-NK1-L-760735
44.44Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
44.44Single7B6WCyclazosin7B6W-α1b-Cyclazosin
44.44Single7EW7PubChem 40774607EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
44.44Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
44.44Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
44.44Single7W41PD1762527W41-BB2-PD176252
44.44Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
44.44Single8EFLSR170188EFL-μ-SR17018-Gi1/&β;1/&γ;2
44.44Single8G056-OAU8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
44.44Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
44.44Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
44.44Single8JXWVUF68848JXW-H4-VUF6884-Gi1/&β;1/&γ;2
44.44Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
44.44Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
44.44Consensus5ht1_offOrthosteric Ligand5ht1b_off
44.44Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
44.44Consensus5ht1b_onOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
44.44Consensusalpha1b_offOrthosteric Ligand7B6W-α1b-Cyclazosin
44.44Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
44.44Consensusbombesin_offOrthosteric Ligandbb2_off
44.44Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
44.44Consensusffa4_onOrthosteric Ligand8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
44.44Consensusgs_compl-peptideOrthosteric Ligand8I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
44.44Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
44.44Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl Scopolamine 5ZHP-M3-PubChem 134828589
44.44Consensussst4_onOrthosteric Ligand7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
43.75Single3RZECidoxepin3RZE-H1-Cidoxepin
43.75Single3UZCPubChem 1355666093UZC-A2A-PubChem 135566609
43.75Single4DKLBeta-funaltrexamine4DKL-μ-Beta-funaltrexamine
43.75Single4MBSMaraviroc4MBS-CCR5-Maraviroc
43.75Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
43.75Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
43.75Single5TE3Octyl Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
43.75Single6IQLL7458706IQL-D4-L745870
43.75Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
43.75Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
43.75Single6V9SGTPL114036V9S-OX1-GTPL11403
43.75Single6VI4JDTic6VI4-κ-JDTic
43.75Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
43.75Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
43.75Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
43.75Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2
43.75Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
43.75Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
43.75Single8GURPubChem 1048958GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2
43.75Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
43.75Single8JERAcipimox8JER-HCA2-Acipimox-Go/&β;1/&γ;2
43.75Single8JIMMMF8JIM-HCA2-MMF-Gi1/&β;1/&γ;2
43.75Single8K5CAcipimox8K5C-HCA2-Acipimox
43.75Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
43.75Consensusdop_off_alloOrthosteric Ligand4N6H-δ-Naltrindole-Na
43.75Consensushca_onOrthosteric Ligandhca2_on hca3_on
43.75Consensushcar_onOrthosteric Ligandhca_on
43.75Consensusm1_off_alloOrthosteric Ligand6WJC-M1-Atropine-Muscarinic toxin 7
43.48Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
43.48Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
43.48Single8IHFMK68928IHF-HCA2-MK6892-Gi1/&β;1/&γ;2
43.48Single8J6IMK68928J6I-HCA2-MK6892-Gi1/&β;1/&γ;2
42.86Single3UZAGTPL92363UZA-A2A-GTPL9236
42.86Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
42.86Single6FUFAll-trans-retinal6FUF-Rhodopsin-All-trans-retinal-Go/&β;1/&γ;2
42.86Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/&β;1/&γ;2
42.86Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
42.86Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
42.86Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
42.86Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
42.86Single8J6RMK68928J6R-HCA2-MK6892-Gi1/&β;1/&γ;2
42.86Single8POKHistamine8POK-H2-Histamine-Gs/&β;1/&γ;2
42.86Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
42.86Consensussst_onOrthosteric Ligandsst2_on sst4_on
42.31Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
42.11Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
42.11Single6CM4Risperidone6CM4-D2-Risperidone
42.11Single6ZG4HTL00099366ZG4-M1-HTL0009936
42.11Single7DFPSpiperone7DFP-D2-Spiperone
42.11Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/&β;1/&γ;2
42.11Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
42.11Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
42.11Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
42.11Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
42.11Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
42.11Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2
42.11Single8JWYPubChem 1684517108JWY-A2A-PubChem 168451710
42.11Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/&β;1/&γ;2
42.11Single8WU1KCA8WU1-CB1-KCA-Arrestin1
42.11Consensusat2_offOrthosteric Ligand7JNI-AT2-Olodanrigan
42.11Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
42.11Consensusgs_bileacidOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
42.11Consensusgs_steroidOrthosteric Ligandgs_bileacid
42.11Consensusgs_trhOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
42.11Consensusleuko_offOrthosteric Ligandblt_off cyslt_off
42.11Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
42.11Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
41.67Consensusbombesin_onOrthosteric Ligandbb2_on bb1_on
41.18Single4DAJTiotropium4DAJ-M3-Tiotropium
41.18Single4MQSIperoxo4MQS-M2-Iperoxo
41.18Single4U14Tiotropium4U14-M3-Tiotropium
41.18Single5DSGTiotropium5DSG-M4-Tiotropium
41.18Single6DRXLisuride6DRX-5-HT2B-Lisuride
41.18Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
41.18Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
41.18Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
41.18Single7SCGFH2107SCG-μ-FH210-Gi1/&β;1/&γ;2
41.18Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
41.18Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
41.18Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
41.18Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
41.18Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
41.18Single8CU6LJ-45178CU6-A2A-LJ-4517
41.18Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
41.18Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/&β;1/&γ;2
41.18Single8J18(3R)-3-hydroxydodecanoic acid8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
41.18Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
41.18Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
41.18Consensusm2_on_alloOrthosteric Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
41.18Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
41.18Consensusm4_on_alloOrthosteric Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
41.18Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
41.18Consensustachykinin_offOrthosteric Ligandnk1_off
40.91Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
40.91Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
40.91Consensusalpha1_offOrthosteric Ligandalpha1a_off alpha1b_off
40.91Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
40.74Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
40.74Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
40.74Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
40.00Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
40.00Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
40.00Single6HLLCP999946HLL-NK1-CP99994
40.00Single6QNOAll-trans-retinal6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
40.00Single6TP4ACT-4622066TP4-OX1-ACT-462206
40.00Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
40.00Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
40.00Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
40.00Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
40.00Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
40.00Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
40.00Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2
40.00Single8IJANiacin8IJA-HCA2-Niacin-Gi1/&β;1/&γ;2
40.00Single8IY9Niacin8IY9-HCA2-Niacin-Go/&β;1/&γ;2
40.00Single8K5BNiacin8K5B-HCA2-Niacin
40.00Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
40.00Consensusbb1_onOrthosteric Ligand8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
40.00Consensusbileacid_onOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
40.00Consensusgs_orexinOrthosteric Ligand7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
40.00Consensusorexin_onOrthosteric Ligandox2_on
40.00Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
40.00Consensussteroid_onOrthosteric Ligandbileacid_on
39.13Single6PT2KGCHM076PT2-δ-KGCHM07
39.13Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
39.13Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
38.89Single5NM2ZM2413855NM2-A2A-ZM241385-Na
38.89Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
38.89Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
38.89Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
38.89Single7SINNPS-21437SIN-CaS-NPS-2143
38.89Single7SINNPS-21437SIN-CaS-NPS-2143
38.89Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2
38.89Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
38.89Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
38.89Single8EA0Iperoxo8EA0-M3-Iperoxo
38.89Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2
38.89Single8ID9Eicosapentaenoic acid8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
38.89Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
38.89Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
38.89Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
38.89Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
38.89Consensuscb2_onOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
38.46Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
38.46Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
38.46Single8GEJEpinephrine8GEJ-β2-Epinephrine-Gs/&β;1/&γ;2
38.46Single8PWNTheophylline8PWN-A2A-Theophylline
38.10Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
38.10Single7SK9CCX6627SK9-ACKR3-CCX662
38.10Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
38.10Single7XN9L-054,5227XN9-SST2-L-054,522
38.10Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
38.10Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2 8I95-C3aB-EP54-Go/&β;1/&γ;2
38.10Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
38.10Consensuslpl_offOrthosteric Ligands1p_off lpa_off
38.10Consensuslpl_onOrthosteric Ligands1p_on lpa_on
37.50Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
37.50Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
37.50Single4S0VSuvorexant4S0V-OX2-Suvorexant
37.50Single5DHHSB-6121115DHH-NOP-SB-612111
37.50Single5K2DZM2413855K2D-A2A-ZM241385
37.50Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
37.50Single6AKYMaraviroc6AKY-CCR5-Maraviroc
37.50Single6JZHZM2413856JZH-A2A-ZM241385-Na
37.50Single6OYAAll-trans-retinal6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
37.50Single6PS7ZM2413856PS7-A2A-ZM241385-Na
37.50Single6TPJSuvorexant6TPJ-OX2-Suvorexant
37.50Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
37.50Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
37.50Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
37.50Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
37.50Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
37.50Single7XRRLemborexant7XRR-OX2-Lemborexant
37.50Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
37.50Single8GNGIstradefylline8GNG-A2A-Istradefylline
37.50Single8HOCImetit8HOC-H4-Imetit-Gi1/&β;1/&γ;2
37.50Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2
37.50Consensusa2a_off_alloOrthosteric Ligand6ZDR-A2A-HMS1413f12-Na 6GT3-A2A-Imaradenant-Na 8CU7-A2A-LJ-4517-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PubChem 92460631; psb36-Na 5MZJ-A2A-Theophylline-Na 5OLO-A2A-Tozadenant-Na 5OLH-A2A-Vipadenant-Na 5NM4-A2A-ZM241385-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5MZP-A2A-Caffeine-Na 8CIC-A2A-Etrumadenant-Na
37.50Consensusgi_histamineOrthosteric Ligand8HN8-H4-Histamine-Gi1/&β;1/&γ;2 8HOC-H4-Imetit-Gi1/&β;1/&γ;2
37.50Consensusgi_somatostatinOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
37.50Consensusgs_histamineOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
37.50Consensusgt_class-aOrthosteric Ligandgt_opsin
37.50Consensusgt_opsinOrthosteric Ligandgt_sensory
37.50Consensusgt_sensoryOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
37.50Consensush4_onOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
37.50Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
37.50Consensusmelatonin_onOrthosteric Ligandmt1_on mt2_on
37.04Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
36.84Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
36.84Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
36.84Single5XR8AM8415XR8-CB1-AM841
36.84Single5XRAAM115425XRA-CB1-AM11542
36.84Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
36.84Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
36.84Single7TUYGSK682753A7TUY-GPR183-GSK682753A
36.84Single7WV9PubMed 1048957WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
36.84Single7XTQR3997XTQ-GPBA-R399-Gs/&β;1/&γ;2
36.84Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2
36.84Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
36.84Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
36.84Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2
36.84Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2
36.84Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/&β;1/&γ;2
36.84Single8JD0J9R8JD0-mGlu2; mGlu3-Glutamate-J9R
36.84Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/&β;1/&γ;2
36.84Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
36.84Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
36.84Consensusadenosine_offOrthosteric Liganda1_off a2_off
36.84Consensusangiotensin_offOrthosteric Ligandat1_off at2_off
36.84Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
36.84Consensusgi_ffaOrthosteric Ligand8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
36.84Consensusgs_ffaOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2 8GDB-EP4-PGE2-Gs/&β;1/&γ;2
36.84Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
36.84Consensuslpa_offOrthosteric Ligandlpa1_off
36.84Consensuslpa_onOrthosteric Ligandlpa1_on
36.84Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
36.84Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
36.36Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
36.36Single7F8XNN90567F8X-CCKA-NN9056
36.36Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
36.36Single8GHVPubChem 1459649038GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
36.36Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
36.36Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
36.00Single7KH0Acyclovir triphosphate7KH0-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
36.00Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
35.71Single6OY9All-trans-retinal6OY9-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
35.71Single7MTBAll-trans-retinal7MTB-Rhodopsin-All-trans-retinal-GRK1
35.71Single8A2OTheophylline8A2O-A2A-Theophylline-Na
35.71Single8IWM2-Phenylethylamine8IWM-TAAR9-2-Phenylethylamine
35.71Single8WC5Tetramethylammonium ion8WC5-TA1-Tetramethylammonium ion-chim(NtGi1-Gs)/&β;1/&γ;2
35.71Consensussensory_onOrthosteric Ligandopsin_on
35.29Single5IU4ZM2413855IU4-A2A-ZM241385-Na
35.29Single5IU7Q274563465IU7-A2A-Q27456346-Na
35.29Single5IUBQ274563445IUB-A2A-Q27456344-Na
35.29Single5JTBZM2413855JTB-A2A-ZM241385
35.29Single5K2BZM2413855K2B-A2A-ZM241385-Na
35.29Single5K2CZM2413855K2C-A2A-ZM241385-Na
35.29Single5NLXZM2413855NLX-A2A-ZM241385-Na
35.29Single5NM4ZM2413855NM4-A2A-ZM241385-Na
35.29Single6AQFZM2413856AQF-A2A-ZM241385
35.29Single6DS0Ly2660976DS0-5-HT2B-Ly266097
35.29Single6TP3Nemorexant6TP3-OX1-Nemorexant
35.29Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
35.29Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
35.29Single7AROLUF58337ARO-A2A-LUF5833-Na
35.29Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
35.29Single7T32ZM2413857T32-A2A-ZM241385
35.29Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
35.29Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
35.29Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
35.29Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2
35.29Single8JHNMMF8JHN-HCA2-MMF-Go/&β;1/&γ;2
35.29Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
35.29Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6WH4-5-HT2A-Methiothepin 7VOE-5-HT2A-Aripiprazole 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 6A93-5-HT2A-Risperidone
35.29Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
35.29Consensusgi_melatoninOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
35.29Consensush3_on_alloOrthosteric Ligand7F61-H3-PF-03654746-Cholesterol
35.29Consensussensory_offOrthosteric Ligandopsin_off
35.00Single6A93Risperidone6A93-5-HT2A-Risperidone
35.00Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
35.00Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
35.00Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
35.00Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
35.00Single7Y24Octreotide7Y24-SST2-Octreotide-Go/&β;1/&γ;2
35.00Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2
35.00Single8JWZAB9288JWZ-A2A-AB928-Na
35.00Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
35.00Consensuscannabinoid_onOrthosteric Ligandcb1_on cb2_on
35.00Consensuscb1_onOrthosteric Ligand8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
35.00Consensusgi_cannabinoidOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
35.00Consensusgi_class-fOther Ligandgi_frizzled
35.00Consensusgi_frizzledOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
35.00Consensuspeptide_offOrthosteric Ligandopioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
35.00Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
34.78Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
34.78Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
34.78Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
34.78Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
34.62Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
33.33Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
33.33Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
33.33Single3EMLZM2413853EML-A2A-ZM241385
33.33Single4EIYZM2413854EIY-A2A-ZM241385-Na
33.33Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
33.33Single4YAYZD-71554YAY-AT1-ZD-7155
33.33Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
33.33Single5IU8Q274563475IU8-A2A-Q27456347-Na
33.33Single5K2AZM2413855K2A-A2A-ZM241385-Na
33.33Single5OLGZM2413855OLG-A2A-ZM241385-Na
33.33Single5TGZAM65385TGZ-CB1-AM6538
33.33Single5UENDU1725UEN-A1-DU172
33.33Single5UIGJ3.651.884G5UIG-A2A-J3.651.884G
33.33Single5VRAZM2413855VRA-A2A-ZM241385-Na
33.33Single5WKTOctyl Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
33.33Single6LPJZM2413856LPJ-A2A-ZM241385-Na
33.33Single6LPKZM2413856LPK-A2A-ZM241385-Na
33.33Single6ME5Agomelatine6ME5-MT1-Agomelatine
33.33Single6ME9Ramelteon6ME9-MT2-Ramelteon
33.33Single6S0LZM2413856S0L-A2A-ZM241385
33.33Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
33.33Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
33.33Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1
33.33Single7MT8All-trans-retinal7MT8-Rhodopsin-All-trans-retinal-GRK1
33.33Single7MT9All-trans-retinal7MT9-Rhodopsin-All-trans-retinal-GRK1
33.33Single7MTAAll-trans-retinal7MTA-Rhodopsin-All-trans-retinal-GRK1
33.33Single7PYRPSB-21157PYR-A2A-PSB-2115
33.33Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
33.33Single7V3ZPubMed 1048957V3Z-CB1-PubMed 104895
33.33Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
33.33Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
33.33Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;2
33.33Single7XZ6APD6687XZ6-GPR119-APD668-Gs/&β;1/&γ;2
33.33Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
33.33Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
33.33Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
33.33Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
33.33Single8EFQDamgo8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
33.33Single8GAGYVF8GAG-CB1-YVF-Gi1/&β;1/&γ;2
33.33Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/&β;1/&γ;2
33.33Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/&β;1/&γ;2
33.33Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
33.33Single8ID8TUG-8918ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
33.33Single8IW72-Phenylethylamine8IW7-TAAR9-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
33.33Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/&β;1/&γ;2
33.33Single8K5DGSK2560738K5D-HCA2-GSK256073
33.33Single8WRZ8D08WRZ-CB1-8D0-Arrestin1
33.33Consensusa2_offOrthosteric Liganda2a_off
33.33Consensusa2a_offOrthosteric Ligand8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 5UIG-A2A-J3.651.884G 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-PubChem 168451710 5K2D-A2A-ZM241385
33.33Consensusangiotensin_onOrthosteric Ligandat1_on
33.33Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
33.33Consensuscb1_on_alloOrthosteric Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
33.33Consensusgi_formylpeptideOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
33.33Consensushca3_onOrthosteric Ligand8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
33.33Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
33.33Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
33.33Consensusopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
32.14Single6IGLIRL16206IGL-ETB-IRL1620
32.14Single8FEGPRD_0025178FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
32.14Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
32.14Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
32.00Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
32.00Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
32.00Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
32.00Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
32.00Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
32.00Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
31.82Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
31.82Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.82Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
31.82Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
31.82Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
31.82Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
31.82Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
31.82Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
31.82Consensusgs_bombesinOrthosteric Ligand8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.58Single5IUAQ274563485IUA-A2A-Q27456348-Na
31.58Single5N2RPubChem 92460631; psb365N2R-A2A-PubChem 92460631; psb36-Na
31.58Single5N2SPSB365N2S-A1-PSB36
31.58Single6D26Fevipiprant6D26-DP2-Fevipiprant
31.58Single6LPLZM2413856LPL-A2A-ZM241385-Na
31.58Single6LUQHaloperidol6LUQ-D2-Haloperidol
31.58Single6S0QZM2413856S0Q-A2A-ZM241385
31.58Single6WQAZM2413856WQA-A2A-ZM241385-Na
31.58Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
31.58Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
31.58Single7RM5ZM2413857RM5-A2A-ZM241385-Na
31.58Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
31.58Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
31.58Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
31.58Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
31.58Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
31.58Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
31.58Single8FYNZM2413858FYN-A2A-ZM241385-Na
31.58Single8GNEKW-63568GNE-A2A-KW-6356-Na
31.58Single8QOTNanobody E8QOT-μ-Nanobody E
31.58Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
31.58Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
31.58Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
31.58Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
31.25Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
31.25Single2G87All-trans-retinal2G87-Rhodopsin-All-trans-retinal
31.25Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
31.25Single3OE9IT1t3OE9-CXCR4-IT1t
31.25Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
31.25Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
31.25Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
31.25Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
31.25Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
31.25Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.25Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.25Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
31.25Single8HN8Histamine8HN8-H4-Histamine-Gi1/&β;1/&γ;2
31.25Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2
31.25Single8ITFDMCHA8ITF-TAAR9-DMCHA-chim(NtGi1-Gs)/&β;1/&γ;2
31.25Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
31.25Consensusmt1_onOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
31.25Consensusmt2_onOrthosteric Ligand7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
31.03Single5GLHEndothelin-15GLH-ETB-Endothelin-1
31.03Single6IGKEndothelin-36IGK-ETB-Endothelin-3
30.77Single5MZPCaffeine5MZP-A2A-Caffeine-Na
30.77Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
30.77Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
30.77Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
30.77Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
30.77Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
30.77Single8WCBCyclohexylammonium ion8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.77Single8WCCCyclohexylammonium ion8WCC-TA1-Cyclohexylammonium ion
30.77Consensusbk1_onOrthosteric Ligand7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.77Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
30.77Consensusgs_bradykininOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.77Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
30.43Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
30.43Single7QA8Peptide7QA8-STE2-Peptide
30.43Single7QA8Peptide7QA8-STE2-Peptide
30.43Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
30.43Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
30.43Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
30.43Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
30.43Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
30.43Consensusclass-d_offOrthosteric Ligandste2_off
30.43Consensusfpr-alx_onOrthosteric Ligandfpr1-alx_on fpr2-alx_on
30.43Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
30.43Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
30.43Consensussst2_onOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
30.00Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
30.00Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
30.00Single7EPENAM5637EPE-mGlu-NAM563
30.00Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2
30.00Single7FEEPubMed 1048957FEE-CB1-PubMed 104895-ZCZ011
30.00Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
30.00Single7PX4PSB-21137PX4-A2A-PSB-2113
30.00Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
30.00Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
30.00Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
30.00Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
30.00Single8GUSHU-3088GUS-CB2-HU-308-Gi1/&β;1/&γ;2
30.00Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
30.00Consensuscck_onOrthosteric Ligandccka_on cckb_on
30.00Consensuscyslt1_off_ortoalloOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
30.00Consensusgi_muscarinicOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
30.00Consensusrelaxin_onOrthosteric Ligandrxfp4_on
29.63Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
29.63Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
29.63Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
29.63Consensusgi_neuromedinOrthosteric Ligand7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
29.63Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
29.63Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
29.41Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
29.41Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
29.41Single3PWHZM2413853PWH-A2A-ZM241385
29.41Single3VG9ZM2413853VG9-A2A-ZM241385-Antibody
29.41Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
29.41Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
29.41Single7F8ULintitript7F8U-CCKA-Lintitript
29.41Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
29.41Single7TUZ7alpha,25-dihydroxycholesterol7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
29.41Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
29.41Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
29.41Single8IHKAcifran8IHK-HCA3-Acifran
29.41Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/&β;1/&γ;2
29.41Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
29.41Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
29.41Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
29.41Consensusmglu_onOther Ligandmglu2_on mglu4_on
29.41Consensusopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
29.17Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
29.17Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
29.17Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
29.17Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
29.17Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
29.17Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
29.17Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
29.17Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
29.03Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
28.57Single3PXOAll-trans-retinal3PXO-Rhodopsin-All-trans-retinal
28.57Single4N4WSANT-14N4W-SMO-SANT-1
28.57Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
28.57Single5DYSAll-trans-retinal5DYS-Rhodopsin-All-trans-retinal
28.57Single6KQIPubMed 1048956KQI-CB1-PubMed 104895-ORG27569
28.57Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
28.57Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
28.57Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.57Single7K15MKD0467K15-BLT1-MKD046-Na
28.57Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.57Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
28.57Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
28.57Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
28.57Single7WCNAR2314537WCN-GPR119-AR231453-Gs/&β;1/&γ;2
28.57Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
28.57Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.57Consensusblt1_offOrthosteric Ligand7K15-BLT1-MKD046-Na
28.57Consensusblt_offOrthosteric Ligandblt1_off
28.57Consensuscb1_off_alloOrthosteric Ligand6KQI-CB1-PubMed 104895-ORG27569
28.57Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
28.57Consensusdp_offOrthosteric Liganddp2_off
28.57Consensusendothelin_onOrthosteric Ligandetb_on eta_on
28.57Consensusgabab_offOther Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
28.57Consensusgpr119_onOrthosteric Ligand7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
28.57Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
28.12Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
28.12Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
28.12Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
28.00Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
28.00Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
28.00Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
28.00Consensusgi_chemerinOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
27.78Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
27.78Single3REYPubChem 56973REY-A2A-PubChem 5697
27.78Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
27.78Single5UVIZM2413855UVI-A2A-ZM241385
27.78Single6MH8ZM2413856MH8-A2A-ZM241385
27.78Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
27.78Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
27.78Single6TPKRetosiban6TPK-OT-Retosiban
27.78Single6ZDVPubChem 9840736ZDV-A2A-PubChem 984073-Na
27.78Single6ZG9GSK10347026ZG9-M1-GSK1034702
27.78Single7BB6Acyclovir triphosphate7BB6-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
27.78Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
27.78Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
27.78Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2
27.78Consensusffa2_onOrthosteric Ligand8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
27.78Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
27.78Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
27.78Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
27.78Consensuss1p_offOrthosteric Ligands1p1_off
27.78Consensusvasopressin-ot_offOrthosteric Ligandot_off
27.59Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
27.59Single7VGXNeuropeptide Y7VGX-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
27.59Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
27.59Consensusgs_endothelinOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
27.27Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
27.27Single6K1QIRL25006K1Q-ETB-IRL2500
27.27Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2
27.27Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
27.27Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
27.27Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.27Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
27.27Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
27.27Consensuscckb_onOrthosteric Ligand7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
27.27Consensusfpa_onOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.27Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
26.92Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
26.92Single6JODAngiotensin II6JOD-AT2-Angiotensin II
26.92Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
26.92Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
26.92Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
26.92Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
26.92Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
26.67Single3RFMCaffeine3RFM-A2A-Caffeine
26.67Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
26.67Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
26.67Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
26.32Single6GPSMK08126GPS-CCR2-MK0812
26.32Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2
26.32Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
26.32Single7CFMP3957CFM-GPBA-P395-Gs/&β;1/&γ;2
26.32Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
26.32Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
26.32Single7VKTLTB47VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
26.32Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
26.32Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
26.32Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
26.32Consensusblt_onOrthosteric Ligandblt1_on
26.32Consensuscck_offOrthosteric Ligandccka_off
26.32Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
26.32Consensusffa_onOrthosteric Ligandffa4_on ffa1_on ffa2_on ffa3_on
26.32Consensusfsh_on_alloOther Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
26.32Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
26.32Consensusleuko_onOrthosteric Ligandblt_on
26.09Single5EE7MK08935EE7-Glucagon-MK0893
26.09Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
26.09Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
26.09Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.09Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.09Single8XZFWN5618XZF-Apelin-WN561-Gi1/&β;1/&γ;2
26.09Consensusclass-d_offOrthosteric Ligandste2_off
26.09Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
26.09Consensusfpr2-alx_onOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
26.09Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
26.09Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
25.93Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
25.93Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
25.93Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
25.93Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.93Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
25.93Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
25.81Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
25.81Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
25.81Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
25.00Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
25.00Single3OE6IT1t3OE6-CXCR4-IT1t
25.00Single3PQRAll-trans-retinal3PQR-Rhodopsin-All-trans-retinal-Gt(CT)
25.00Single4WW3All-trans-retinal4WW3-Rhodopsin-All-trans-retinal
25.00Single4XT1Fractalkine4XT1-US28-Fractalkine
25.00Single5CGCHTL142425CGC-mGlu5-HTL14242
25.00Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
25.00Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
25.00Single6GPXMK08126GPX-CCR2-MK0812
25.00Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
25.00Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
25.00Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
25.00Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
25.00Single7C4SS1P7C4S-S1P3-S1P
25.00Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
25.00Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
25.00Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single7WC5Psilocin7WC5-5-HT2A-Psilocin
25.00Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Single7Y27Somatostatin-147Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Single7YXAONO-54306087YXA-S1P5-ONO-5430608
25.00Single8F76-8F76-OR51E2-Gs/&β;1/&γ;2
25.00Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2
25.00Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/&β;1/&γ;2
25.00Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
25.00Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
25.00Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
25.00Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
25.00Consensusclass-d_onOrthosteric Ligandste2_on
25.00Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
25.00Consensusgs_sstOrthosteric Ligand7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
25.00Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
24.24Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
24.24Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
24.14Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
24.14Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
24.14Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
24.14Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
24.14Consensusetb_onOrthosteric Ligand8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
24.14Consensusgi_class-dOrthosteric Ligandgi_ste
24.14Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
24.14Consensusgo_class-b1Orthosteric Ligandgo_crf
24.14Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
24.00Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/&β;1/&γ;2
24.00Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
24.00Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
24.00Consensuscx3cr_onOrthosteric Ligandcx3cr1_on
23.81Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
23.81Single7XOWGastrin7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
23.81Single7XOXCholecystokinin-87XOX-CCKB-Cholecystokinin-8-Gq/&β;1/&γ;2
23.81Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
23.81Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
23.81Single8X79MRE-2698X79-I2-MRE-269-Gs/&β;1/&γ;2
23.81Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
23.81Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
23.81Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
23.81Consensusnpy_offOrthosteric Ligandnpy2_off npy1_off
23.53Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
23.53Single3AYMAll-trans-retinal3AYM-Rhodopsin-All-trans-retinal
23.53Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
23.53Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
23.53Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
23.53Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
23.53Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
23.53Single8JILNiacin8JIL-HCA2-Niacin-Gi1/&β;1/&γ;2
23.53Consensuspth_onOrthosteric Ligandpth1_on pth2_on
23.33Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
23.33Consensuscrf1_onOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
23.08Single3OE0CVX153OE0-CXCR4-CVX15
23.08Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
23.08Single6W25SHU91196W25-MC4-SHU9119-Ca
23.08Single7F4DAlpha-MSH7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
23.08Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
23.08Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
23.08Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
23.08Consensuscx3cr1_onOrthosteric Ligand7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
23.08Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
22.73Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
22.73Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
22.73Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
22.73Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
22.73Single7Y66BM2137Y66-C5a1-BM213-Gi1/&β;1/&γ;2
22.73Single8GCPPGE28GCP-EP4-PGE2-Gi1/&β;1/&γ;2
22.73Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2
22.73Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
22.73Single8J6DEP1418J6D-C3aB-EP141-Go/&β;1/&γ;2
22.73Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
22.73Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg3_on
22.73Consensusclass-b2_onOrthosteric Ligandadgrg_on
22.73Consensusgi_prostanoidOrthosteric Ligand8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GDC-EP3-PGE2-Gi1/&β;1/&γ;2 8GCM-EP4-L902688-Gi1/&β;1/&γ;2
22.73Consensusprostanoid_onOrthosteric Ligandep_on fpa_on
22.73Consensustsh_on_alloOther Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
22.58Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
22.58Consensusgs_crfOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
22.22Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
22.22Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
22.22Single3ODUIT1t3ODU-CXCR4-IT1t
22.22Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
22.22Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
22.22Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
22.22Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
22.22Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
22.22Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.22Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
22.22Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
22.22Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
22.22Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
22.22Single7W0OElabela7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
22.22Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
22.22Single8A6CAll-trans-retinal8A6C-Rhodopsin-All-trans-retinal
22.22Single8A6DAll-trans-retinal8A6D-Rhodopsin-All-trans-retinal
22.22Single8A6EAll-trans-retinal8A6E-Rhodopsin-All-trans-retinal
22.22Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
22.22Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
22.22Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
22.22Consensusclass-d_onOrthosteric Ligandste2_on
22.22Consensusffa3_on_alloOrthosteric Ligand8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
22.22Consensusgi_class-dOrthosteric Ligandgi_ste
22.22Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
22.22Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
22.22Consensusnmur_onOrthosteric Ligandnmur1_on nmur2_on
21.88Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
21.88Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
21.74Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
21.74Single5CGDHTL142425CGD-mGlu5-HTL14242
21.74Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
21.74Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
21.74Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.74Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
21.74Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.74Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.74Consensusc5a1_off_ortoalloOrthosteric Ligand6C1Q-C5a1-PMX53-NDT9513727 6C1R-C5a1-PMX53-Avacopan; Na
21.74Consensusep4_onOrthosteric Ligand7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2
21.74Consensusgs_lipidOrthosteric Ligandgs_ffa gs_prostanoid
21.74Consensusgs_prostanoidOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.74Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.74Consensusot_onOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
21.43Single4A4MAll-trans-retinal4A4M-Rhodopsin-All-trans-retinal-Gt(CT)
21.43Single5EN0All-trans-retinal5EN0-Rhodopsin-All-trans-retinal-Gt(CT)
21.43Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
21.43Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.43Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
21.43Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
21.43Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
21.43Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
21.43Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.43Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
21.43Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.43Consensusgs_melanocortinOrthosteric Ligand7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2
21.43Consensusgs_neuromedinOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.05Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
21.05Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
21.05Single7VODCariprazine7VOD-5-HT2A-Cariprazine
21.05Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
21.05Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
21.05Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.05Single8GCML9026888GCM-EP4-L902688-Gi1/&β;1/&γ;2
21.05Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.05Single8HQN9(S)-HODE8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
21.05Single8K4NVF08K4N-GPR34-VF0-Gi1/&β;1/&γ;2
21.05Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
20.83Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
20.83Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.83Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
20.83Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
20.83Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.83Consensusgo_vasopressinOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
20.83Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
20.83Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.69Single4XT3Fractalkine4XT3-US28-Fractalkine
20.69Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
20.69Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
20.69Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/&β;1/&γ;2
20.69Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
20.69Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
20.69Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
20.59Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
20.59Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
20.51Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
20.00Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
20.00Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
20.00Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
20.00Single6D27CAY104716D27-DP2-CAY10471
20.00Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
20.00Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
20.00Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
20.00Single6IIVDaltroban6IIV-TP-Daltroban
20.00Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
20.00Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
20.00Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
20.00Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
20.00Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
20.00Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
20.00Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
20.00Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Single7WC4Serotonin7WC4-5-HT2A-Serotonin
20.00Single7XKEBetahydroxyandrosterone7XKE-ADGRG2-Betahydroxyandrosterone-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
20.00Single8EJCTAK-8758EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
20.00Single8EJKTAK-8758EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
20.00Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
20.00Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
20.00Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-alpha-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
20.00Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
20.00Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
20.00Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
20.00Consensushcar_offOrthosteric Ligandsuccinate_off
20.00Consensusnmur1_onOrthosteric Ligand7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Consensusp2y12_offOrthosteric Ligand4NTJ-P2Y12-AZD1283 7PP1-P2Y12-Selatogrel
20.00Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
20.00Consensusprostanoid_offOrthosteric Ligandep_off tp_off dp_off
20.00Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
20.00Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
20.00Consensustp_offOrthosteric Ligand6IIV-TP-Daltroban 6IIU-TP-Ramatroban
19.35Single6LMLGlucagon6LML-Glucagon-Glucagon
19.35Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
19.35Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
19.35Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
19.35Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
19.35Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
19.35Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
19.35Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
19.35Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
19.35Single8IY6Endothelin-18IY6-ETB-Endothelin-1
19.35Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
19.35Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
19.23Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
19.23Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
19.23Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
19.23Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.23Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.23Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
19.05Single4NTJAZD12834NTJ-P2Y12-AZD1283
19.05Single4PHUFasiglifam4PHU-FFA1 (GPR40)-Fasiglifam
19.05Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
19.05Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
19.05Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
19.05Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
19.05Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
19.05Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
19.05Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
19.05Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
19.05Single8FN1Neurotensin/neuromedin N8FN1-NTS1-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
19.05Single8GDAL9026888GDA-EP4-L902688-Gs/&β;1/&γ;2
19.05Single8GDCPGE28GDC-EP3-PGE2-Gi1/&β;1/&γ;2
19.05Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
19.05Consensusccr2_off_alloOther Ligand5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
19.05Consensusep3_onOrthosteric Ligand8GDC-EP3-PGE2-Gi1/&β;1/&γ;2
19.05Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
19.05Consensusep_offOrthosteric Ligandep4_off
18.75Single2HPYAll-trans-retinal2HPY-Rhodopsin-All-trans-retinal
18.75Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
18.75Single6TQ9SB-4081246TQ9-OX1-SB-408124
18.75Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
18.52Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
18.52Single7XNACYN1548067XNA-SST2-CYN154806
18.52Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
18.52Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.52Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.52Consensusmc5_onOrthosteric Ligand8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
18.52Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
18.52Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
18.18Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
18.18Single5TZR-5TZR-FFA1 (GPR40)-MK8666
18.18Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
18.18Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
18.18Single7P2L4YI7P2L-mGlu5-4YI
18.18Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
18.18Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
18.18Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.18Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2
18.18Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
18.18Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.18Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
18.18Consensuschemerin_onOrthosteric Ligandcml1_on
18.18Consensuscml1_onOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
18.18Consensusglp_onOrthosteric Ligandglp1_on glp2_on
18.18Consensuss1p2_onOrthosteric Ligand7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
17.86Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
17.86Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
17.86Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
17.86Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
17.86Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
17.86Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
17.86Consensusnmur2_onOrthosteric Ligand7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.86Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
17.86Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
17.65Single3OE8IT1t3OE8-CXCR4-IT1t
17.65Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
17.65Single8EITDoconexent8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
17.65Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
17.65Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
17.65Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
17.50Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
17.39Single4PY02MeSATP4PY0-P2Y12-2MeSATP
17.39Single4XEENeurotensin4XEE-NTS1-Neurotensin
17.39Single4XESNeurotensin4XES-NTS1-Neurotensin
17.39Single5X33BIIL2605X33-BLT1-BIIL260
17.39Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
17.39Single6IIURamatroban6IIU-TP-Ramatroban
17.39Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
17.39Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2
17.39Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/&β;1/γ1
17.39Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
17.39Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
17.39Single8IBUErythromycin A8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.39Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
17.39Consensusep_onOrthosteric Ligandep4_on ep2_on ep3_on
17.24Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
17.24Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
17.24Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
17.24Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
17.24Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.24Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
17.14Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
17.14Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
16.67Single4BUONeurotensin4BUO-NTS1-Neurotensin
16.67Single5L7IVismodegib5L7I-SMO-Vismodegib
16.67Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
16.67Single6FJ3PTH6FJ3-PTH1-PTH
16.67Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
16.67Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
16.67Single7D3SSecretin7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
16.67Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
16.67Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
16.67Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
16.67Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
16.67Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
16.67Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/&β;1/&γ;2
16.67Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
16.67Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
16.67Single8X2K5YM8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Consensusadgrg2_onOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
16.67Consensusclass-t_onOrthosteric Ligandtaste2_on
16.67Consensuscyslt2_offOrthosteric Ligand6RZ6-CysLT2-ONO-2570366 6RZ9-CysLT2-ONO-2770372 6RZ8-CysLT2-ONO-2080365
16.67Consensuscyslt_offOrthosteric Ligandcyslt2_off
16.67Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
16.67Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
16.67Consensusgs_class-tOrthosteric Ligandgs_taste
16.67Consensusgs_tasteOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
16.67Consensustaste2_onOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
16.13Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
16.13Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
16.13Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
16.13Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
16.13Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
16.00Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
16.00Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
16.00Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.00Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
16.00Single8SAI1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
16.00Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
16.00Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
16.00Consensusgs_adgrOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
16.00Consensusgs_class-b2Orthosteric Ligandgs_adgr
16.00Consensusmotilin_onOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.00Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
15.79Single5U09Taranabant5U09-CB1-Taranabant
15.79Single5ZKQABT-4915ZKQ-PAF-ABT-491
15.79Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
15.79Single7BR3Elagolix7BR3-GnRH1-Elagolix
15.79Single7F8YDevazepide7F8Y-CCKA-Devazepide
15.79Single8HMPPubChem 699214798HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
15.79Single8U8FPML8U8F-GPR3-PML-Gs/&β;1/&γ;2
15.79Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
15.79Consensusp2y_offOrthosteric Ligandp2y1_off p2y12_off
15.62Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
15.38Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/&β;1/&γ;1
15.38Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
15.38Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
15.00Single6FFIMMPEP6FFI-mGlu5-MMPEP
15.00Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
15.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
15.00Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
15.00Single7XOVSR1461317XOV-CCKA-SR146131-Gs/&β;1/&γ;2
15.00Single8K2WAMG4878K2W-CXCR3-AMG487
15.00Single8T3VDHA8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.00Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
15.00Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/&β;1/&γ;2
15.00Consensusgnrh_offOrthosteric Ligandgnrh1_off
15.00Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
15.00Consensuslh_on_alloOther Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
14.81Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
14.81Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
14.81Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
14.81Consensussst_offOrthosteric Ligandsst2_off
14.71Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
14.29Single4QIMPubChem 249053754QIM-SMO-PubChem 24905375
14.29Single6FFHFenobam6FFH-mGlu5-Fenobam
14.29Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
14.29Single7F83PF-051904577F83-Ghrelin-PF-05190457
14.29Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
14.29Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
14.29Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/&β;1/&γ;2
14.29Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
14.29Consensusffa1_onOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.29Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
13.89Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
13.79Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
13.79Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
13.79Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
13.64Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
13.64Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
13.64Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
13.64Single8JPCNeurotensin 8-138JPC-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
13.51Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
13.33Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
13.33Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
13.04Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
13.04Single4BV0Neurotensin4BV0-NTS1-Neurotensin
13.04Single5V56TC1145V56-SMO-TC114
13.04Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
13.04Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2
13.04Single7F1TMIP-1a7F1T-CCR5-MIP-1a
13.04Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1
13.04Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/&β;1/&γ;1
13.04Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.04Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.04Single8FMZNeurotensin/neuromedin N8FMZ-NTS1-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.04Single8GDBPGE28GDB-EP4-PGE2-Gs/&β;1/&γ;2
13.04Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
13.04Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
13.04Consensusmglu2_onOther Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
13.04Consensusnts1_on_alloOrthosteric Ligand8JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
12.90Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
12.90Single7SK3CXCL127SK3-ACKR3-CXCL12
12.90Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
12.90Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
12.90Consensusghrh_onOrthosteric Ligand7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
12.82Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
12.50Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
12.50Single4GRVNeurotensin 8-134GRV-NTS1-Neurotensin 8-13
12.50Single6OS2TRV0266OS2-AT1-TRV026
12.50Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/&β;1/&γ;2
12.50Single6YVRNTS8-136YVR-NTS1-NTS8-13
12.50Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1
12.50Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
12.50Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
12.50Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/&β;1/&γ;2
12.50Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/&β;1/&γ;2
12.50Single8JPBNeurotensin 8-138JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
12.50Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
12.50Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
12.50Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
12.50Consensuschemokine_offOrthosteric Ligandcxcr_off
12.50Consensusclass-c_onOther Ligandgabab_on mglu_on
12.50Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II
12.50Consensuscxcr_offOrthosteric Ligandcxcr4_off
12.50Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
12.50Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
12.50Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
12.50Consensusnts1_offOrthosteric Ligand6Z4Q-NTS1-SR142948A 6Z4S-NTS1-SR48692
12.50Consensusnts_offOrthosteric Ligandnts1_off
12.12Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
12.12Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
12.12Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
12.12Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
12.00Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
12.00Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2
12.00Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
12.00Consensusep2_onOrthosteric Ligand7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
12.00Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.00Consensusgi_neurotensinOrthosteric Ligand7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
12.00Consensusgs_galaninOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.76Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
11.76Single7VDMSubstance P7VDM-MRGPRX2-Substance P-Gi1/&β;1/&γ;2
11.76Single7XKDBetahydroxyandrosterone7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
11.76Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/&β;1/&γ;2
11.76Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
11.76Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
11.54Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
11.54Single8INRAlpha-MSH8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
11.43Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
11.11Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
11.11Single6LI0GTPL98046LI0-GPR52-GTPL9804
11.11Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
11.11Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
11.11Single7S8O(R)-Zinc-35737S8O-MRGPRX2-(R)-Zinc-3573-Gi1/&β;1/&γ;2
11.11Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
11.11Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/&β;1/&γ;2
11.11Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
11.11Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
11.11Consensusgip_on_alloOther Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
11.11Consensussmo_off_alloOrthosteric Ligand6D32-SMO-Cyclopamine-Cyclopamine
10.81Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
10.71Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
10.71Single7SK5CXCL127SK5-ACKR3-CXCL12
10.71Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.71Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
10.53Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
10.53Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
10.53Single7S8N(R)-Zinc-35737S8N-MRGPRX2-(R)-Zinc-3573-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.53Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
10.53Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
10.53Consensusgo_adhesionOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
10.53Consensusgo_class-b2Orthosteric Ligandgo_adhesion
10.53Consensussmo_on_alloOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
10.34Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.26Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
10.00Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
10.00Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
10.00Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
10.00Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
10.00Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
10.00Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
10.00Single8DWHCompound-168DWH-MRGPRX1-Compound-16-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.00Single8FN0Neurotensin/neuromedin N8FN0-NTS1-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
10.00Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
10.00Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
10.00Consensusm2_on_alloOther Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
10.00Consensussmo_on_alloOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
9.52Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
9.52Single6ZINSR486926ZIN-NTS1-SR48692
9.52Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
9.52Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.52Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
9.52Single7VV6C48/807VV6-MRGPRX2-C48/80
9.52Single7VVOPTH7VVO-PTH1-PTH-Gs/&β;1/&γ;2
9.52Single7XJJGalanin7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
9.52Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.52Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
9.52Consensuscxcr_onOrthosteric Ligandcxcr1_on cxcr2_on
9.52Consensusgo_galaninOrthosteric Ligand7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
9.52Consensusm1_off_alloOther Ligand6WJC-M1-Atropine-Muscarinic toxin 7
9.09Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
9.09Single5T04Neurotensin5T04-NTS1-Neurotensin
9.09Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
9.09Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
9.09Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
9.09Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
9.09Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
9.09Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
9.09Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/&β;1/&γ;2
9.09Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
9.09Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
9.09Consensussmo_offOrthosteric Ligand5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
8.82Consensuscalcitonin_onOrthosteric Ligandct_on ctlike_on
8.70Single4JKVTaladegib (LY2940680)4JKV-SMO-Taladegib (LY2940680)
8.70Single6Z4SSR486926Z4S-NTS1-SR48692
8.70Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
8.33Single5V57TC1145V57-SMO-TC114
8.33Single6OS1TRV0266OS1-AT1-TRV026
8.33Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
8.00Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
8.00Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.00Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.00Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.00Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.00Consensusnts1_onOrthosteric Ligand6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
8.00Consensusnts_onOrthosteric Ligandnts1_on
7.69Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/&β;1/&γ;2
7.69Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
7.69Single7CX2PGE27CX2-EP2-PGE2-Gs/&β;1/&γ;2
7.69Consensusclass-c_offOther Ligandgabab_off mglu_off
7.41Single6KNMJN241-96KNM-Apelin-JN241-9
7.14Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
6.90Single7SHEPI; PE7SHE-GPR158-PI; PE
6.25Single6W25Ca6W25-MC4-SHU9119-Ca
6.25Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
6.25Consensusccr8_offOrthosteric Ligand8TLM-CCR8-Anti-murine CCR8 antibody
5.88Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
5.56Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
5.56Single7Y14Beta-alanine7Y14-MRGPRD-Beta-alanine
5.56Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/&β;1/&γ;2
5.26Single4XNWMRS25004XNW-P2Y1-MRS2500
5.26Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
5.26Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
5.26Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2
5.26Single7Y12Beta-alanine7Y12-MRGPRD-Beta-alanine-Gi1/&β;1/&γ;2
5.26Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
5.00Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
5.00Single4O9RCyclopamine4O9R-SMO-Cyclopamine
5.00Single7XKFBetahydroxyandrosterone7XKF-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
5.00Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
5.00Consensusgo_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
5.00Consensusgo_proteinOrthosteric Ligandgo_chemokine
5.00Consensusm4_on_alloOther Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
4.76Single4BWBNeurotensin4BWB-NTS1-Neurotensin
4.76Single4QINSAG1.54QIN-SMO-SAG1.5
4.76Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
4.76Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
4.76Single6WWZCCL206WWZ-CCR6-CCL20-Go/&β;1/&γ;2
4.76Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
4.76Consensusclass-f_offOrthosteric Ligandsmo_off
4.55Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
4.55Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
4.55Single8IYXYL-3658IYX-GPR34-YL-365
4.55Single8JD6N-(3-chlorophenyl)pyridine-2-carboxamide8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
4.55Consensusgi_class-fOrthosteric Ligandgi_frizzled
4.55Consensusgi_frizzledOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
4.55Consensusgs_ctOrthosteric Ligand7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
4.35Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/&β;1/&γ;2
4.35Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
4.35Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
4.00Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
4.00Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
3.85Single7SHEPI; PE7SHE-GPR158-PI; PE
3.70Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
3.70Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
3.45Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
3.33Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
2.78Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
2.70Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
2.70Single7TYIAmylin7TYI-CT-Amylin-Gs/&β;1/&γ;2
2.70Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
2.63Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
2.56Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
2.56Single8F0KPramlintide analogue san3858F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.50Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
2.50Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
2.38Single8F2APramlintide analogue san3858F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.27Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
2.22Single8F2BPramlintide analogue san458F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
2.13Single8F0JPramlintide analogue san458F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2

Consensus Members
Id Members
7F0T 7F0T-D1-Dopamine-Gs/&β;1/&γ;2
7CKX 7CKX-D1-A77636-Gs/&β;1/&γ;2
7JVQ 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
7CKY 7CKY-D1-PW0464-Gs/&β;1/&γ;2
8IRV 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
7JV5 7JV5-D1-SKF81297-Gs/&β;1/&γ;2
7JVP 7JVP-D1-SKF83959-Gs/&β;1/&γ;2
7X2D 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2
7JOZ 7JOZ-D1-VFP-Gs/&β;1/&γ;2
Net Summary
Imin 3.02111
Number of Linked Nodes 1004
Number of Links 1201
Number of Hubs 188
Number of Links mediated by Hubs 725
Number of Communities 24
Number of Nodes involved in Communities 233
Number of Links involved in Communities 345
Path Summary
Number Of Nodes in MetaPath 141
Number Of Links MetaPath 140
Number of Shortest Paths 10345831
Length Of Smallest Path 3
Average Path Length 51.3418
Length of Longest Path 88
Minimum Path Strength 0.316667
Average Path Strength 5.31564
Maximum Path Strength 21.2061
Minimum Path Correlation 0.7
Average Path Correlation 0.987969
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.21951
Average % Of Corr. Nodes 20.505
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 56.5307
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following consensuses:
IdComponents
gs_aminegs_5ht
gs_adrenergic
gs_dopamine
gs_histamine
gs_muscarinic
gs_tar



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