Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
1G.S1.02 4.38475535
2G.H1.01 4.008509
3G.H1.04 3.17906407
4G.H1.07 3.60094409
5G.H1.08 3.59125438
6G.S2.08 7.965435
7G.S3.01 5.56219434
8G.S3.03 7.26525537
9G.S3.04 7.96312416
10G.S3.05 3.3385537
11G.S3.06 7.00075515
12G.H2.03 4.97469419
13G.H2.04 3.30219409
14G.H2.06 5.38104619
15G.H2.07 4.8775519
16G.H2.09 4.37406418
17G.h2s4.01 6.14525519
18G.S4.04 6.59188449
19G.S4.06 4.12313407
20G.s4h3.04 7.331874138
21G.s4h3.05 6.938444139
22G.H3.01 5.339064199
23G.H3.09 5.30062649
24G.H3.13 3.49563445
25G.H3.15 3.82562418
26G.H3.17 7.07812615
27G.H3.18 5.30969419
28G.S5.04 3.56175549
29G.S5.05 3.7795539
30G.S5.06 4.96031408
31G.HG.04 5.55355139
32G.hgh4.02 5.40854647
33G.hgh4.05 7.89594407
34G.H4.03 5.013504
35G.H4.15 4.2595548
36G.h4s6.02 4.47375448
37G.S6.02 6.69219437
38G.s6h5.01 5.53719439
39G.s6h5.05 2.15232739
40G.H5.03 4.67225538
41G.H5.08 5.19563638
42G.H5.13 5.74094438
43G.H5.21 2.47312405
44G.H5.26 6.56025535
45b.1x11 3.69187408
46b.1x19 4.97062456
47b.lh12x2 5.65531408
48b.h2x1 3.96094405
49b.lhb1x6 3.771874163
50b.l1x3 8.36917699
51b.l1x6 9.39419
52b.b2x1 5.79125518
53b.b2x5 5.528336127
54b.l3x2 5.90656499
55b.b4x3 3.72938467
56b.b4x6 10.4035599
57b.b5x2 5.17781407
58b.b5x3 6.53275599
59b.b5x5 4.75969465
60b.b5x7 5.12594467
61b.l5x1 4.045468
62b.l5x5 6.35268719
63b.b6x5 3.7015506
64b.b7x1 6.01969404
65b.b7x4 3.4355568
66b.b8x3 3.59438406
67b.b8x4 4.18393766
68b.l8x8 4.30031464
69b.b9x3 5.18466
70b.l9x3 5.94854619
71b.l9x6 4.46333918
72b.b10x5 3.97125609
73b.l10x1 3.58281403
74b.l11x2 6.986519
75b.b12x6 7.05911718
76b.b12x7 4.733754229
77b.b13x7 7.1575577
78b.l13x3 8.09375579
79b.l13x6 4.6635519
80b.b14x3 4.24125475
81b.b15x1 7.15781479
82b.l15x2 5.85375479
83b.b16x4 8.246576
84b.b16x6 8.61525578
85b.b17x4 6.012194175
86b.b17x7 7.53969458
87b.l17x3 8.37083659
88b.l17x6 6.61438419
89b.b18x3 5.24781458
90b.l18x1 5.541876146
91b.l18x2 5.352194147
92b.b19x2 5.77375656
93b.l19x2 6.02325559
94b.b20x4 8.534558
95b.b20x6 6.9105556
96b.b21x1 9.87437457
97b.b21x2 2.10313406
98b.b21x5 4.64375484
99b.b21x7 4.83729685
100b.l21x2 5.67344404
101b.b22x5 4.295426147
102b.l22x5 5.322086169
103b.b23x6 5.74018787
104b.l23x1 7.84531406
105b.b24x4 6.14656486
106b.b24x6 5.78719488
107b.l24x3 4.04469405
108b.b25x3 6.44156485
109b.l25x3 8.201755119
110b.l26x1 6.07754127
111b.l27x1 8.69946719
112b.b28x4 7.454374116
113b.b28x6 8.9395119
114g.h1x11 2.54575509
115g.h1x12 2.32469406
116g.l1x4 4.36425558
117g.h2x11 8.2354146
118g.ctx3 6.49625409
119g.ctx6 2.928336166
120g.ctx14 4.529255109
121g.ctx16 4.616098108
122Lig 23.64862120
123NT 7.5745525
1241x43 4.5025406
1251x50 5.26531409
126I1 1.69687406
1272x42 5.195607
1282x50 5.90175509
1292x64 2.8675405
130E1x52 5.40938407
1313x50 4.73688409
1323x54 3.31125408
1333x55 6.058444187
134I2x53 3.280944155
135I2x57 6.167255157
1364x65 6.93062425
137E2 18.9711923
138E2x52 5.71313425
1395x35 3.01375523
1405x36 4.754524
1415x50 3.22375409
1425x58 5.64396628
1435x60 4.02754183
144I3 5.982631034
1456x47 3.94575508
1466x48 5.90021629
1476x51 7.92313427
148E3 8.83031423
1497x30 3.09375404
1507x47 2.41719407
1518x50 5.70594409
1528x53 2.77175504
153b.1x1 1.08469400
154b.1x4 1.68406400
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1b.b2x3 b.b2x5 17.02092.7625NoYes1267
2b.b26x2 b.b2x3 17.37595.67125NoNo076
3b.b26x1 b.b26x2 17.72673.44NoNo097
4b.b26x1 b.l27x1 17.90415.25NoYes099
5b.l1x6 b.l27x1 20.842221.4675YesYes199
6b.l1x6 b.l3x1 21.15193.39YesNo199
7b.l3x1 b.l5x5 42.38196.025NoYes199
8b.b2x1 b.l27x1 20.84214.70125YesYes189
9b.b2x1 b.l3x1 21.147510.145YesNo189
10G.h2s4.01 b.l5x5 55.01959.2725YesYes199
11G.H2.07 G.h2s4.01 56.11883.3825YesYes199
12G.H2.04 G.H2.07 89.52335.5YesYes099
13G.H2.04 G.H3.08 99.96072.4275YesNo099
14G.H3.08 G.S4.04 1004.87375NoYes099
15G.S4.04 G.S4.06 49.14893.275YesYes097
16G.S4.06 G.S5.06 48.26343.16625YesYes078
17G.S5.06 G.s4h3.01 49.47785.8825YesNo087
18G.HG.04 G.s4h3.01 49.365810.0475YesNo097
19G.H4.03 G.HG.04 47.8623.225YesYes049
20G.H4.03 G.HG.01 94.59876.26875YesNo045
21G.HG.01 G.s6h5.02 94.46736.66875NoNo057
22G.s6h5.02 G.s6h5.05 94.20432.5275NoYes079
23G.S4.04 G.S5.04 49.18673.3475YesYes499
24G.S5.04 G.S5.06 48.37853.635YesYes098
25G.S5.06 G.S6.05 47.1317.1575YesNo084
26G.H4.07 G.S6.05 47.19453.1175NoNo054
27G.H4.03 G.H4.07 47.13852.6675YesNo045
28G.H5.03 G.s6h5.05 88.04652.69375YesYes389
29G.H5.03 G.S6.04 82.42293.03YesNo389
30G.H5.06 G.S6.04 82.362619.3725NoNo339
31G.H5.06 I3 82.22733.75NoYes334
32G.H3.15 G.H3.18 10.05943.77375YesYes189
33G.H3.18 G.S4.02 10.25766.75375YesNo198
34G.S1.07 G.S4.02 10.46882.675NoNo098
35G.H3.12 G.S1.07 10.52435.3525NoNo089
36G.H2.07 b.l9x6 49.7862.6525YesYes198
37b.l11x1 b.l9x6 10.88365.61375NoYes198
38b.b11x6 b.l11x1 10.80593.71NoNo199
39G.H2.06 b.l9x6 40.753.43125YesYes198
40G.H2.06 b.l17x6 20.26647.7775YesYes199
41G.H2.06 b.b18x1 20.27093.4975YesNo099
42b.l25x6 b.l27x1 23.667917.3662NoYes189
432x42 3x46 12.64494.8425YesNo078
443x46 3x50 12.79844.85375NoYes089
453x50 G.H5.25 43.61553.79625YesNo097
466x33 G.H5.25 44.04546.07875NoNo077
476x33 I3 44.1892.68NoYes374
48b.l17x6 b.l19x1 20.24332.9925YesNo099
49b.l17x5 b.l19x1 40.23993.49625NoNo069
50b.l17x5 b.l19x2 40.0553.49375NoYes069
51b.l17x3 b.l19x2 27.53733.9375YesYes599
52b.b19x4 b.l17x3 15.20929.06875NoYes089
53b.b19x4 b.b20x6 11.01456.64625NoYes086
54b.b17x7 b.b20x6 26.74648.43875YesYes586
55b.b17x7 b.b21x1 25.05556.11875YesYes587
56b.1x19 b.b21x1 22.7668.78375YesYes567
57b.1x15 b.1x19 17.04774.69875NoYes076
58b.1x15 g.h1x11 15.90251.6075NoYes079
59b.1x11 g.h1x11 13.61155.36375YesYes089
60b.b18x1 b.l19x1 20.18158.91875NoNo099
61b.b20x4 b.l17x3 11.585115.2337YesYes589
62b.b20x4 b.b20x6 22.02473.61YesYes586
63b.b20x2 b.l19x2 11.95818.31NoYes069
64b.b20x2 b.b20x4 11.58087.76125NoYes068
65b.1x11 g.h1x12 11.89274.5825YesYes086
66b.b9x3 b.l7x5 12.77015.635YesNo066
67b.l7x3 b.l7x5 12.92626.65NoNo096
68b.l5x3 b.l7x3 13.00928.09375NoNo089
69b.l5x3 b.l5x5 13.09642.78125NoYes089
70b.l23x1 b.l25x6 33.205620.695YesNo068
71b.l21x7 b.l23x1 18.04744.86NoYes056
72b.b23x6 b.l21x7 16.74043.52625YesNo875
73b.b21x7 b.b24x6 12.34756.63125YesYes858
74b.b23x6 b.b24x6 12.84195.54625YesYes878
75b.b22x1 b.l23x1 14.74582.89125NoYes086
76b.b22x2 b.b26x3 14.23293.9425NoNo086
777x45 7x49 15.12167.8325NoNo099
786x48 7x45 19.06477.91YesNo099
796x44 6x48 57.26657.1425NoYes299
805x54 6x44 59.69134.79375NoNo289
815x54 5x58 59.87173.68625NoYes288
823x50 5x58 30.75126.81625YesYes098
835x58 6x37 30.64038.7825YesNo087
845x62 6x37 30.78483.085NoNo057
855x62 5x66 31.21843.29NoNo054
865x66 I3 31.36423.24875NoYes344
876x48 6x51 37.91374.46125YesYes297
886x51 Lig 26.690817.9813YesYes270
89g.h1x12 g.h1x8 10.17351.32875YesNo067
90G.H2.04 G.H3.12 10.60572.975YesNo098
91b.b22x1 b.b22x2 14.48513.4NoNo088
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
E2Lig45.6352YesYes3010
LigNT11.99752YesYes0501
E2x51Lig3.48250NoYes4010
5x36Lig3.98252YesYes4010
E1Lig5.816252NoYes4010
7x31Lig3.92752NoYes4010
4x65Lig2.841252YesYes5010
E2x52Lig3.082YesYes5010
7x34Lig17.47252NoYes4010
7x35Lig3.25752NoYes4010
2x60Lig3.97750NoYes6010
3x29Lig2.8752NoYes6010
3x32Lig3.038752NoYes6010
6x51Lig17.98132YesYes7010
6x55Lig4.448750NoYes5010
7x38Lig8.501252NoYes5010
NTNT10.34382YesYes5511
2x67NT3.06750NoYes2521
2x563x322.746250NoNo6621
2x63E12.683752NoNo4411
2x647x353.411250YesNo5421
E1x49E212.72NoYes4321
3x283x292.9250NoNo5621
3x294x659.908752NoYes6511
4x64E25.298752NoYes4321
4x645x355.64752NoYes4322
4x65E2x503.656252YesNo5912
4x65E2x5211.31622YesYes5511
E2E241.10752YesYes3311
E2E2x525.818752YesYes3511
5x36E211.81252YesYes4311
5x366x593.526252YesNo4512
6x486x514.461252YesYes9721
6x516x527.19252YesNo7812
6x547x303.413752NoYes4412
6x547x376.87252NoNo4612
E3E311.68882YesYes3311
7x277x313.10NoNo3421
7x347x382.67752NoNo4511
E3Lig9.782YesYes3010
5x35E23.19752YesYes3321
2x63Lig3.391252NoYes4010
3x22E24.06252NoYes3321
5x36E2x522.63752YesYes4511
6x54Lig2.3252NoYes4010
7x24E32.163752NoYes4321
1x33NT2.122NoYes5521
5x436x512.05750NoYes6721
5x335x361.811250NoYes2421

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
94.74Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
86.36Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
78.95Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
73.68Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
66.67Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
66.67Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
66.67Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
65.00Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
65.00Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
62.50Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
62.50Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
61.90Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
60.00Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
60.00Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
60.00Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
60.00Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
58.33Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
58.33Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
58.33Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
58.33Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
58.33Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
58.33Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
57.89Single6D27CAY104716D27-DP2-CAY10471
57.69Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
57.69Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
57.69Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
57.14Single5GLHEndothelin-15GLH-ETB-Endothelin-1
57.14Single6IGKEndothelin-36IGK-ETB-Endothelin-3
57.14Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
57.14Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
56.52Single9HB3Mambaquaretin-19HB3-V2-Mambaquaretin-1
56.00Single8ZBISomatostatin-148ZBI-SST3-Somatostatin-14-Gi1/β1/γ2
56.00Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
55.56Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
55.56Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
55.56Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
55.56Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
55.00Single6D26Fevipiprant6D26-DP2-Fevipiprant
55.00Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
55.00Consensusdp_offOrthosteric Liganddp2_off
54.55Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
54.55Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
54.17Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
54.17Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
53.85Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
53.85Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
53.85Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
53.57Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
53.57Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
53.57Consensusbradykinin_onOrthosteric Ligandbk2_on
53.57Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
53.57Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
52.38Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
52.38Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
52.38Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
52.38Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
52.17Single8QJ2pN1628QJ2-MC4-pN162-Gs
52.17Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
52.17Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
52.17Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
52.00Consensusangiotensin_onOrthosteric Ligandat1_on
52.00Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
52.00Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
52.00Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
52.00Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
52.00Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
51.72Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
50.00Single6OS2TRV0266OS2-AT1-TRV026
50.00Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
50.00Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
50.00Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
50.00Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
50.00Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
50.00Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
50.00Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
50.00Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
50.00Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
50.00Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
50.00Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
50.00Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
50.00Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
50.00Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
50.00Consensuslpl_offOrthosteric Ligands1p_off lpa_off
48.39Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
48.28Single6IGLIRL16206IGL-ETB-IRL1620
48.28Single8IY6Endothelin-18IY6-ETB-Endothelin-1
48.28Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
48.28Consensusendothelin_onOrthosteric Ligandetb_on eta_on
48.15Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
48.15Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
48.15Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
48.15Single8ZRTET-18ZRT-ETB-ET-1
48.15Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
48.00Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
48.00Single7XNACYN1548067XNA-SST2-CYN154806
48.00Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
48.00Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
48.00Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
48.00Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
48.00Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
48.00Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
48.00Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
48.00Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
47.83Single4BUONeurotensin4BUO-NTS1-Neurotensin
47.83Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
47.83Consensusprostanoid_offOrthosteric Ligandep_off dp_off
47.37Single8GNGIstradefylline8GNG-A2A-Istradefylline
47.37Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
46.43Single4XT3Fractalkine4XT3-US28-Fractalkine
46.43Single7SK3CXCL127SK3-ACKR3-CXCL12
46.43Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
46.43Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
46.43Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
46.15Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
46.15Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
45.83Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
45.83Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
45.83Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
45.83Single7XN9L-054,5227XN9-SST2-L-054,522
45.83Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
45.83Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
45.83Single9IPVJR14a9IPV-C3aB-JR14a-Gi1/β1/γ2
45.83Single9IPYJR14a9IPY-C3aB-JR14a
45.45Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
45.45Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
45.45Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
45.45Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
45.45Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
45.45Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
45.45Single8ZWFJR14a8ZWF-C3aB-JR14a
45.45Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
45.00Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
45.00Single7AROLUF58337ARO-A2A-LUF5833-Na
45.00Single7T94LY21196207T94-M2-Acetylcholine-LY2119620-chim(NtGi1-Go)/β1/γ2
45.00Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
45.00Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
45.00Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
44.83Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
44.83Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
44.83Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
44.44Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
44.44Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
44.44Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
44.44Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
44.44Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
44.44Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
44.44Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
44.44Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
44.44Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
44.00Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
44.00Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
44.00Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
44.00Single8ZBJSomatostatin-148ZBJ-SST5-Somatostatin-14-Gi1/β1/γ2
44.00Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
44.00Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
44.00Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
44.00Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
44.00Consensussomatostatin_offOrthosteric Ligandsst2_off
44.00Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
43.48Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
43.48Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
43.48Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
43.48Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
43.48Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
43.48Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
43.48Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
43.48Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
43.48Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
43.48Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
43.48Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
43.48Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
43.48Consensuslpa_offOrthosteric Ligandlpa1_off
43.48Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
43.48Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
43.48Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
43.33Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
42.86Single5UENDU1725UEN-A1-DU172
42.86Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
42.86Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
42.86Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
42.86Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
42.86Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
42.86Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
42.86Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
42.86Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
42.86Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
42.86Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
42.86Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
42.86Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
42.86Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
42.42Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
42.31Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
42.31Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
42.31Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
42.31Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
42.31Single9IK8SST analogue9IK8-SST1-SST analogue-Gi1/β1/γ2
42.31Single9IQRMuscarinic toxin 39IQR-α2a-Muscarinic toxin 3
42.31Single9IQSMuscarinic toxin 39IQS-M4-Muscarinic toxin 3
42.31Single9IQVMuscarinic toxin 39IQV-Alpha1A-Muscarinic toxin 3
42.31Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
42.11Single3OE9IT1t3OE9-CXCR4-IT1t
41.94Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
41.94Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
41.94Consensusbombesin_onOrthosteric Ligandbb2_on
41.94Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
41.94Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
41.94Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
41.94Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
41.94Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
41.94Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
41.67Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
41.67Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
41.67Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-SBI-553-chim(NtGi1-Go)/β1/γ2
41.67Single8ZPLHF511168ZPL-CXCR4-HF51116
41.67Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
41.38Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
41.38Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
41.38Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
41.38Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
41.38Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
41.38Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
41.38Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
40.91Single5IUAQ274563485IUA-A2A-Q27456348-Na
40.91Single5N2RPSB-365N2R-A2A-PSB-36-Na
40.91Single5N2SPSB365N2S-A1-PSB36
40.91Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
40.91Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
40.91Single6S0QZM-2413856S0Q-A2A-ZM-241385
40.91Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
40.91Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
40.91Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
40.91Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
40.91Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
40.91Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
40.91Single8ZYTNeurotensin peptide 8-138ZYT-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
40.91Single9CIBFCH-22964139CIB-HCA2-FCH-2296413
40.91Single9EHSLUF76029EHS-A3A-LUF7602
40.91Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
40.91Consensusadenosine_offOrthosteric Liganda1_off a2_off
40.91Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
40.74Single3OE0CVX153OE0-CXCR4-CVX15
40.74Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
40.74Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
40.74Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
40.74Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
40.74Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
40.74Single9U4WGonadoliberin-19U4W-GnRH1-Gonadoliberin-1-chim(NtGi1L-Gs-CtGq)/β1/γ2
40.74Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
40.74Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
40.74Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
40.74Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
40.74Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
40.62Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
40.62Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
40.00Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
40.00Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
40.00Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
40.00Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
40.00Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
40.00Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
40.00Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
40.00Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
40.00Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
40.00Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
40.00Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
40.00Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
40.00Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
40.00Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
40.00Single8XQJJN2418XQJ-Apelin-JN241
40.00Single8YYWAlpha-ketoglutarate8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
40.00Single8YYWAlpha-ketoglutarate8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
40.00Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
40.00Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
40.00Single9V2NMacimorelin9V2N-Ghrelin-Macimorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
40.00Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
40.00Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
40.00Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
40.00Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
40.00Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
40.00Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
40.00Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
40.00Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
40.00Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
39.39Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
39.29Single6JODAngiotensin II6JOD-AT2-Angiotensin II
39.29Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
39.29Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
39.29Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
39.29Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
39.29Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
39.29Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
39.29Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
39.29Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
39.29Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
39.29Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
39.29Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
39.29Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
39.29Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
39.29Consensusvasop-oxy_onOrthosteric Ligandv2_on
39.29Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
39.13Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
39.13Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
39.13Single6OS1TRV0266OS1-AT1-TRV026
39.13Single7PX4PSB-21137PX4-A2A-PSB-2113
39.13Single7TUYGSK682753A7TUY-GPR183-GSK682753A
39.13Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
39.13Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
39.13Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
39.13Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
39.13Single9IK9SST analogue9IK9-SST1-SST analogue-Gi1/β1/γ2
39.13Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
39.13Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
39.13Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
39.13Consensusneurotensin_onOrthosteric Ligandnts1_on
39.13Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
39.13Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
39.13Consensusrelaxin_onOrthosteric Ligandrxfp4_on
39.13Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
38.71Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
38.71Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
38.71Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
38.46Single4XT1Fractalkine4XT1-US28-Fractalkine
38.46Single7F8XNN90567F8X-CCKA-NN9056
38.46Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
38.46Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
38.46Single8U4OCXCL128U4O-CXCR4-CXCL12-Gi1/β1/γ2
38.46Single8WDTphotoNECA8WDT-A2A-photoNECA
38.46Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
38.46Single9BUYLM1899BUY-β2-LM189-Gi1/β1/γ2
38.46Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
38.46Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
38.46Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
38.46Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
38.46Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
38.46Consensuslpl_onOrthosteric Ligands1p_on lpa_on
38.46Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
38.46Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
38.46Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
38.46Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
38.10Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
38.10Single5IUBQ274563445IUB-A2A-Q27456344-Na
38.10Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
38.10Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
38.10Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
38.10Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
38.10Single6MH8ZM-2413856MH8-A2A-ZM-241385
38.10Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
38.10Single7F61PF-036547467F61-H3-PF-03654746
38.10Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
38.10Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
38.10Single8ZPMAMD0708ZPM-CXCR4-AMD070
38.10Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
38.10Consensusgrh_offOrthosteric Ligandgnrh1_off
38.10Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
38.10Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
37.93Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
37.93Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
37.93Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
37.93Single9JFYhNPSF9JFY-NPFF2-hNPSF-Gi1/β1/γ2
37.93Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
37.93Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
37.93Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
37.50Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
37.50Single4XEENeurotensin4XEE-NTS1-Neurotensin
37.50Single4XESNeurotensin4XES-NTS1-Neurotensin
37.50Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
37.50Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
37.50Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
37.50Single6YVRNTS8-136YVR-NTS1-NTS8-13
37.50Single7K15MKD0467K15-BLT1-MKD046-Na
37.50Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
37.50Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
37.50Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
37.50Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
37.50Single8JJLOlodaterol8JJL-β2-Olodaterol
37.50Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
37.50Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
37.50Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
37.50Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
37.50Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
37.50Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
37.50Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
37.50Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
37.50Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
37.50Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
37.50Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
37.50Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
37.50Consensusorexin_onOrthosteric Ligandox2_on
37.04Single3QAKUK-4320973QAK-A2A-UK-432097
37.04Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
37.04Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
37.04Single7SK5CXCL127SK5-ACKR3-CXCL12
37.04Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
37.04Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
37.04Single9E82SDF-1-beta9E82-ACKR3-SDF-1-β-Arrestin2
37.04Single9KFIRelaxin-39KFI-RXFP3-Relaxin-3-Gi2/β1/γ2
37.04Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
37.04Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
37.04Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
37.04Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
37.04Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
37.04Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
36.84Single3OE6IT1t3OE6-CXCR4-IT1t
36.67Single9KFKRelaxin-39KFK-RXFP4-Relaxin-3-Gi2/β1/γ2
36.67Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
36.67Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
36.67Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
36.36Single3EMLZM-2413853EML-A2A-ZM-241385
36.36Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
36.36Single5IU8Q274563475IU8-A2A-Q27456347-Na
36.36Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
36.36Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
36.36Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
36.36Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
36.36Single6S0LZM-2413856S0L-A2A-ZM-241385
36.36Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
36.36Single7PYRPSB-21157PYR-A2A-PSB-2115
36.36Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
36.36Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
36.36Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
36.36Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
36.36Single8CU6LJ-45178CU6-A2A-LJ-4517
36.36Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
36.36Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
36.36Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
36.36Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
36.36Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
36.36Single8K5DGSK2560738K5D-HCA2-GSK256073
36.36Single9H37A1IR09H37-A2A-A1IR0-Na
36.36Single9IZCMK19039IZC-HCA2-MK1903-Gi1/β1/γ2
36.36Consensuscck_offOrthosteric Ligandccka_off
36.36Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
36.36Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
36.36Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
36.36Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
36.36Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
36.36Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
36.36Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
36.36Consensushca_on_gpOrthosteric Ligandhca2_on_gp
36.36Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
36.36Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
36.36Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
36.36Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
36.36Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
36.11Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
36.00Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
36.00Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
36.00Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
36.00Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
36.00Single7EZCUKA7EZC-A2A-UKA
36.00Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
36.00Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
36.00Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
36.00Single8JPFNeurotensin8JPF-NTS1-Neurotensin-SBI-553
36.00Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
36.00Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
36.00Single8ZWGJR14a8ZWG-C3aB-JR14a-Gi1/β1/γ2
36.00Consensuscck_onOrthosteric Ligandccka_on cckb_on
36.00Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
36.00Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
36.00Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
35.71Single5WF5UK-4320975WF5-A2A-UK-432097
35.71Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
35.71Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
35.71Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
35.71Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
35.71Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
35.71Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
35.71Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
35.71Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
35.48Single8W8WAlpha-MSH8W8W-MC3-α-MSH-Ca-Gs/β1/γ2
35.48Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
35.48Single9KDFRES-701-39KDF-ETB-RES-701-3
35.00Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
35.00Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
35.00Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
34.78Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
34.78Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
34.78Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
34.78Single7C61Ergotamine7C61-5-HT1B-Ergotamine
34.78Single7W41PD1762527W41-BB2-PD176252
34.78Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
34.78Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
34.78Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
34.78Single8GNEKW-63568GNE-A2A-KW-6356-Na
34.78Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
34.78Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
34.78Single8S4DCMF-0198S4D-Apelin-CMF-019
34.78Single8TF5Oleic acid8TF5-GPR6-Oleic acid
34.78Single8WGBVU01550418WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
34.78Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
34.78Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
34.78Consensusbombesin_offOrthosteric Ligandbb2_off
34.78Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
34.78Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
34.62Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
34.62Single5WF6UK-4320975WF6-A2A-UK-432097
34.62Single6KNMJN241-96KNM-Apelin-JN241-9
34.62Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
34.62Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
34.62Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
34.62Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
34.62Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
34.62Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
34.62Single8Y72Peptide8Y72-μ-Peptide-BMS-986122-Gi1/β1/γ2
34.62Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
34.62Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
34.62Single9IZASCH9002719IZA-HCA2-SCH900271-Gi1/β1/γ2
34.62Single9M0RNeuropeptide VF9M0R-NPFF1-Neuropeptide VF-Gi1/β1/γ2
34.62Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
34.62Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
34.48Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
34.48Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
34.48Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
34.48Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
33.33Single3ODUIT1t3ODU-CXCR4-IT1t
33.33Single3PWHZM-2413853PWH-A2A-ZM-241385
33.33Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
33.33Single4BV0Neurotensin4BV0-NTS1-Neurotensin
33.33Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
33.33Single4IARErgotamine4IAR-5-HT1B-Ergotamine
33.33Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
33.33Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
33.33Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
33.33Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
33.33Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
33.33Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
33.33Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
33.33Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
33.33Single7BR3Elagolix7BR3-GnRH1-Elagolix
33.33Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
33.33Single7F8YDevazepide7F8Y-CCKA-Devazepide
33.33Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
33.33Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
33.33Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
33.33Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
33.33Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
33.33Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
33.33Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
33.33Single7XRRLemborexant7XRR-OX2-Lemborexant
33.33Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
33.33Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
33.33Single8E0GBU728E0G-μ-BU72
33.33Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
33.33Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
33.33Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
33.33Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
33.33Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
33.33Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
33.33Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
33.33Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
33.33Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
33.33Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
33.33Single8XWNCXCL88XWN-CXCR2-CXCL8
33.33Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
33.33Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
33.33Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
33.33Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single9JMCDS-3801b9JMC-Motilin-DS-3801b-chim(Gs-CtGq)/β1/γ2
33.33Single9UY3Anamorelin9UY3-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
33.33Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
33.33Consensuslpa_onOrthosteric Ligandlpa1_on
33.33Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
33.33Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
33.33Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
33.33Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
33.33Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
33.33Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
33.33Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
33.33Consensuspac_onOrthosteric Ligandpac1_on
32.26Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
32.26Consensuspac_on_gpOrthosteric Ligandpac1_on_gp
32.14Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
32.14Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
32.14Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
32.14Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
32.14Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
32.14Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
32.14Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
32.00Single6MXTSalmeterol6MXT-β2-Salmeterol
32.00Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
32.00Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
32.00Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
32.00Single8XQJJN2418XQJ-Apelin-JN241
32.00Single9M4QDoxazosin9M4Q-Alpha1A-Doxazosin
32.00Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
32.00Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
32.00Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
32.00Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
31.82Single3REYXAC3REY-A2A-XAC
31.82Single5IU7Q274563465IU7-A2A-Q27456346-Na
31.82Single5JTBZM-2413855JTB-A2A-ZM-241385
31.82Single5UVIZM-2413855UVI-A2A-ZM-241385
31.82Single6AQFZM-2413856AQF-A2A-ZM-241385
31.82Single6V9SGTPL114036V9S-OX1-GTPL11403
31.82Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
31.82Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
31.82Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
31.82Single7T32ZM-2413857T32-A2A-ZM-241385
31.82Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
31.82Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
31.82Single8IHKAcifran8IHK-HCA3-Acifran
31.82Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
31.82Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
31.82Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
31.82Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
31.82Single8K5CAcipimox8K5C-HCA2-Acipimox
31.82Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
31.82Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
31.82Single8Y6YGLPG09748Y6Y-FFA2-GLPG0974
31.82Single9JFUNE52-QQ579JFU-GPR4-NE52-QQ57
31.82Single9JMDAzithromycin9JMD-Motilin-Azithromycin-chim(Gs-CtGq)/β1/γ2
31.82Single9K0KUTP9K0K-P2Y4-UTP-chim(NtGi1-Gs-CtGq)/β1/γ2
31.82Single9K0XATP9K0X-P2Y2-ATP-chim(NtGi1-Gs-CtGq)/β1/γ2
31.82Single9K20ATP9K20-P2Y2-ATP-chim(NtGi1-Go)/β1/γ2
31.82Consensusa2_offOrthosteric Liganda2a_off
31.82Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
31.82Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
31.82Consensushca_onOrthosteric Ligandhca2_on
31.58Single8A2OTheophylline8A2O-A2A-Theophylline-Na
31.25Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
31.25Single8W8XBeta-MSH8W8X-MC3-β-MSH-Ca-Gs/β1/γ2
31.03Single6PT2KGCHM076PT2-δ-KGCHM07
31.03Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
31.03Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
31.03Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
31.03Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
31.03Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
31.03Single9M1OMorphine-Modulating Neuropeptide B9M1O-NPFF2-Morphine-Modulating Neuropeptide B-Gi1/β1/γ2
31.03Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
31.03Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
30.95Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
30.77Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
30.77Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
30.77Single6IBLArformoterol6IBL-β1-Arformoterol
30.77Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
30.77Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
30.77Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
30.77Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
30.77Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
30.77Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
30.77Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
30.77Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
30.77Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
30.77Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
30.77Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
30.77Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
30.77Single8XVUCXCL28XVU-CXCR2-CXCL2
30.77Single8XWFCXCL38XWF-CXCR2-CXCL3
30.77Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
30.77Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
30.77Single9M54Neuropeptide VF9M54-NPFF2-Neuropeptide VF-Gi1/β1/γ2
30.77Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
30.77Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
30.77Consensuschemerin_onOrthosteric Ligandcml1_on
30.77Consensusendothelin_offOrthosteric Ligandetb_off
30.77Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
30.77Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
30.77Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
30.77Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
30.56Consensusclass-a_class-b1_cons_on_gpOrthosteric Ligandclass-a_on_gp class-b1_on_gp
30.43Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
30.43Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
30.43Single5UIGCmpd-15UIG-A2A-Cmpd-1
30.43Single6TOTLemborexant6TOT-OX1-Lemborexant
30.43Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
30.43Single6XBM5LWE6XBM-SMO-5LWE-Gi1/β1/γ2
30.43Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
30.43Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
30.43Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
30.43Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
30.43Single7UL4Alvimopan7UL4-μ-Alvimopan
30.43Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
30.43Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
30.43Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
30.43Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
30.43Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
30.43Single8TH3AT118-H Nanobody8TH3-AT1-AT118-H Nanobody
30.43Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
30.43Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
30.43Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
30.43Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
30.00Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
30.00Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
30.00Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
30.00Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
30.00Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/β1/γ2
30.00Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
30.00Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
30.00Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
30.00Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
29.63Single4UG2CGS216804UG2-A2A-CGS21680
29.63Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
29.63Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
29.63Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
29.63Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
29.63Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
29.63Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
29.63Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
29.63Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
29.63Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
29.41Consensusclass-a_class-b1_cons_onOrthosteric Ligandclass-a_on class-b1_on
29.17Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
29.17Single5C1MBU725C1M-μ-BU72
29.17Single5WQCEMPA5WQC-OX2-EMPA
29.17Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
29.17Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
29.17Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
29.17Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
29.17Single7LD3Adenosine7LD3-A1-Adenosine-MIPS521-Gi2/β1/γ2
29.17Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
29.17Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
29.17Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
29.17Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
29.17Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
29.17Single8QOTNanobody-E8QOT-μ-Nanobody-E
29.17Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
29.17Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
29.17Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
29.17Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
29.17Single9I52A1IZU9I52-D1-A1IZU-Gs/β1/γ2
29.17Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
29.17Consensusblt_offOrthosteric Ligandblt1_off
29.17Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
29.17Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
29.17Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
29.17Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
29.17Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
29.03Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
29.03Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
29.03Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
29.03Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
28.57Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
28.57Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
28.57Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
28.57Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
28.57Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
28.57Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
28.57Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
28.57Single8IEBA1LYA8IEB-GPR156-A1LYA
28.57Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
28.57Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
28.57Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
28.57Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
28.57Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
28.57Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
28.57Single9LMPNE52-QQ579LMP-GPR4-NE52-QQ57
28.57Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
28.57Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
28.57Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
28.57Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
28.57Consensusgq_nucleotideOrthosteric Ligandgq_p2y
28.57Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
28.57Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
28.57Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
28.12Single6FJ3PTH6FJ3-PTH1-PTH
28.12Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
28.12Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
28.12Consensuspac1_onOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
28.12Consensuspac1_on_gpOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
28.00Single3P0GBI1671073P0G-β2-BI167107
28.00Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
28.00Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
28.00Single5V56TC1145V56-SMO-TC114
28.00Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
28.00Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
28.00Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
28.00Single7B6WCyclazosin7B6W-α1b-Cyclazosin
28.00Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
28.00Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
28.00Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
28.00Single7F1TMIP-1a7F1T-CCR5-MIP-1a
28.00Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
28.00Single7R0CAVP7R0C-V2-AVP-Arrestin2
28.00Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
28.00Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
28.00Single7T9NDPPC7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
28.00Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
28.00Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
28.00Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
28.00Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
28.00Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
28.00Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
28.00Single8XVLZibotentan8XVL-ETA-Zibotentan
28.00Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
28.00Single8Y73Peptide8Y73-μ-Peptide-MPAM-15-Gi1/β1/γ2
28.00Single9I54A1IZV9I54-D1-A1IZV-Gs/β1/γ2
28.00Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
28.00Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
28.00Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
28.00Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
28.00Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
28.00Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
28.00Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
28.00Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
27.59Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
27.59Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
27.59Single9J0FNADH9J0F-P2Y14-NADH-Gi1/β1/γ2
27.59Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
27.59Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
27.59Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
27.27Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
27.27Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
27.27Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
27.27Single4BWBNeurotensin4BWB-NTS1-Neurotensin
27.27Single4S0VSuvorexant4S0V-OX2-Suvorexant
27.27Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
27.27Single5WS3EMPA5WS3-OX2-EMPA
27.27Single6DS0Ly2660976DS0-5-HT2B-Ly266097
27.27Single6TPJSuvorexant6TPJ-OX2-Suvorexant
27.27Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
27.27Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
27.27Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
27.27Single7F8ULintitript7F8U-CCKA-Lintitript
27.27Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
27.27Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
27.27Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
27.27Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
27.27Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
27.27Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
27.27Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
27.27Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
27.27Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
27.27Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
27.27Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
27.27Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
27.27Single9EEAAdenosine9EEA-A2A-Adenosine-Gs/β1/γ2
27.27Single9H2XA1IR19H2X-A2A-A1IR1-Na
27.27Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
27.27Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
27.27Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
27.27Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
27.27Consensusorexin_offOrthosteric Ligandox2_off ox1_off
27.27Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
27.27Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
27.27Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
26.92Single4LDEBI1671074LDE-β2-BI167107
26.92Single4RWADIPP-NH24RWA-δ-DIPP-NH2
26.92Single6A93Risperidone6A93-5-HT2A-Risperidone
26.92Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
26.92Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
26.92Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
26.92Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
26.92Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
26.92Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
26.92Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
26.92Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
26.92Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
26.92Single7YITNalfurafine7YIT-κ-Nalfurafine
26.92Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
26.92Single8JJ8Formoterol8JJ8-β2-Formoterol
26.92Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
26.92Single8JWY2-1188JWY-A2A-2-118
26.92Single8JWZAB9288JWZ-A2A-AB928-Na
26.92Single8XWACXCL18XWA-CXCR2-CXCL1
26.92Single8XWMCXCL68XWM-CXCR2-CXCL6
26.92Single8XWSCXCL58XWS-CXCR2-CXCL5
26.92Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
26.92Single9GL2Befiradol9GL2-5-HT1A-Befiradol-Gs/β1/γ2
26.92Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
26.92Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
26.92Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
26.92Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
26.92Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
26.92Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
26.92Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
26.92Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
26.92Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
26.92Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
26.67Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
26.67Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
26.47Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
26.47Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
26.47Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
26.47Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
26.47Single9BYOExendin-39BYO-GLP-1-Exendin-3-Gs/β1/γ2
26.47Consensusvip-pacap_onOrthosteric Ligandvpac_on pac_on
26.47Consensusvip-pacap_on_gpOrthosteric Ligandvpac_on_gp pac_on_gp
26.32Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
26.32Single7V68LY21196207V68-M4-Iperoxo-LY2119620-Gi1/β1/γ2
26.32Single8PWNTheophylline8PWN-A2A-Theophylline
26.09Single2YDOAdenosine2YDO-A2A-Adenosine
26.09Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
26.09Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
26.09Single4MBSMaraviroc4MBS-CCR5-Maraviroc
26.09Single4ZJCSB-6740424ZJC-OX1-SB-674042
26.09Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
26.09Single6IQLL7458706IQL-D4-L745870
26.09Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
26.09Single6TP3Nemorexant6TP3-OX1-Nemorexant
26.09Single6TPGEMPA6TPG-OX2-EMPA
26.09Single6ZINSR486926ZIN-NTS1-SR48692
26.09Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
26.09Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
26.09Single7UTZDPPC7UTZ-TSH-TR1402-DPPC-Gs/β1/γ2
26.09Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
26.09Single8RLNLUF58348RLN-A2A-LUF5834
26.09Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.09Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
26.09Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
26.09Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
26.09Single9BA0A1AKN9BA0-CB1-A1AKN
26.09Single9JH3CMF-0199JH3-Apelin-CMF-019-Gi1/β1/γ2
26.09Single9KPDSA09KPD-TAS2R16-SA0-chim(Gs-CtGt3)/β1/γ2
26.09Single9M2FNeuropeptide FF9M2F-NPFF1-Neuropeptide FF-Gi1/β1/γ2
26.09Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
26.09Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
26.09Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
25.93Single5X93K-87945X93-ETB-K-8794
25.93Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
25.93Single6H7LDobutamine6H7L-β1-Dobutamine
25.93Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
25.93Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
25.93Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
25.93Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
25.93Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
25.93Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
25.93Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
25.93Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
25.93Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
25.93Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
25.93Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
25.93Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
25.93Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
25.93Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
25.93Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
25.81Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
25.81Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
25.81Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
25.71Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
25.00Single2Y02Carmoterol2Y02-β1-Carmoterol
25.00Single3NY9ICI118-5513NY9-β2-ICI118-551
25.00Single3OE8IT1t3OE8-CXCR4-IT1t
25.00Single3RFMCaffeine3RFM-A2A-Caffeine
25.00Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
25.00Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
25.00Single4QIMANTA XV4QIM-SMO-ANTA XV
25.00Single4YAYZD-71554YAY-AT1-ZD-7155
25.00Single5T04Neurotensin5T04-NTS1-Neurotensin
25.00Single5TGZAM65385TGZ-CB1-AM6538
25.00Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
25.00Single5ZTYAM102575ZTY-CB2-AM10257
25.00Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
25.00Single6PS1Timolol6PS1-β2-Timolol
25.00Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
25.00Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
25.00Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
25.00Single7BU7BI1671077BU7-β1-BI167107
25.00Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
25.00Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
25.00Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
25.00Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
25.00Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
25.00Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
25.00Single7V3ZCP559407V3Z-CB1-CP55940
25.00Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
25.00Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
25.00Single7YXAONO-54306087YXA-S1P5-ONO-5430608
25.00Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
25.00Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
25.00Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
25.00Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
25.00Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
25.00Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
25.00Single8X5YAstemizole8X5Y-H1-Astemizole
25.00Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
25.00Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
25.00Single8ZYYNeurotensin peptide 8-138ZYY-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
25.00Single9CHXS-Carazolol9CHX-β2-S-Carazolol
25.00Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
25.00Single9JGKBalovaptan9JGK-5-HT2B-Balovaptan
25.00Single9KFJPubChem 1383196749KFJ-RXFP3-PubChem 138319674-Gi2/β1/γ2
25.00Consensusa3_onOrthosteric Liganda3a_on
25.00Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
25.00Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
25.00Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
25.00Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
25.00Consensusglp1_onOrthosteric Ligand7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
25.00Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
25.00Consensuskisspeptin_onOrthosteric Ligandkiss1_on
24.32Consensuscrf_on_gpOrthosteric Ligandcrf2_on_gp crf1_on_gp
24.32Consensusglp1_on_gpOrthosteric Ligand7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
24.24Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
24.24Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
24.24Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
24.14Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
24.14Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
24.14Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
24.14Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
24.14Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
24.14Single8IEIA1LYA8IEI-GPR156-A1LYA
24.14Single8IEIA1LYA8IEI-GPR156-A1LYA
24.14Single8IEPA1LYA8IEP-GPR156-A1LYA
24.14Single8IEPA1LYA8IEP-GPR156-A1LYA
24.14Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
24.14Single8PKMBefiradol8PKM-5-HT1A-Befiradol-Gi1/β1/γ1
24.14Single8WKYPG-9348WKY-MC4-PG-934
24.14Single9J0IUDP-Glucuronic acid9J0I-P2Y14-UDP-Glucuronic acid-Gi1/β1/γ2
24.00Single2Y00Dobutamine2Y00-β1-Dobutamine
24.00Single4JKVTaladegib4JKV-SMO-Taladegib
24.00Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
24.00Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
24.00Single6E67BI1671076E67-β2-BI167107-Gs(CT)
24.00Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
24.00Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
24.00Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
24.00Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
24.00Single6TP6Filorexant6TP6-OX1-Filorexant
24.00Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
24.00Single6Z4SSR486926Z4S-NTS1-SR48692
24.00Single7SINNPS-21437SIN-CaS-NPS-2143
24.00Single7SINNPS-21437SIN-CaS-NPS-2143
24.00Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
24.00Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
24.00Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
24.00Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
24.00Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
24.00Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
24.00Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
24.00Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
24.00Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
24.00Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
24.00Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
24.00Single8JXSPF-61428JXS-D1-PF-6142
24.00Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
24.00Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
24.00Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
24.00Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
24.00Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
24.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
24.00Single9B9ZA1AKO9B9Z-CB1-A1AKO
24.00Single9EE8Adenosine9EE8-A2A-Adenosine-Gs/β1/γ2
24.00Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
24.00Single9F34FOB02-04A9F34-D3-FOB02-04A-Go/β1/γ2
24.00Single9HAPTolvaptan9HAP-V2-Tolvaptan
24.00Single9KPFSA09KPF-TAS2R16-SA0-Gi1/β1/γ2
24.00Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
24.00Consensusa3_on_gpOrthosteric Liganda3a_on_gp
24.00Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
24.00Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
24.00Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
24.00Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
24.00Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
24.00Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
24.00Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
24.00Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
24.00Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
24.00Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
24.00Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
24.00Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
24.00Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
23.81Single4XNWMRS25004XNW-P2Y1-MRS2500
23.81Single7WC5Psilocin7WC5-5-HT2A-Psilocin
23.81Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
23.81Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
23.81Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
23.68Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
23.68Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
23.53Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
23.53Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
23.53Consensusglp_onOrthosteric Ligandglp1_on glp2_on
23.53Consensusglp_on_gpOrthosteric Ligandglp1_on_gp glp2_on_gp
23.33Single6HLOAprepitant6HLO-NK1-Aprepitant
23.33Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
23.33Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
23.33Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
23.33Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
23.33Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
23.33Single8IEBA1LYA8IEB-GPR156-A1LYA
23.33Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
23.08Single2YDVNECA2YDV-A2A-NECA
23.08Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
23.08Single4UHRCGS216804UHR-A2A-CGS21680
23.08Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
23.08Single5G53NECA5G53-A2A-NECA-Gs
23.08Single5V57TC1145V57-SMO-TC114
23.08Single5XRAAM115425XRA-CB1-AM11542
23.08Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
23.08Single6H7JIsoprenaline6H7J-β1-Isoprenaline
23.08Single6J20Aprepitant6J20-NK1-Aprepitant
23.08Single6J21Aprepitant6J21-NK1-Aprepitant
23.08Single6TQ7SB-3348676TQ7-OX1-SB-334867
23.08Single6WGTLSD6WGT-5-HT2A-LSD
23.08Single7FEECP559407FEE-CB1-CP55940-ZCZ011
23.08Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
23.08Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
23.08Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
23.08Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
23.08Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
23.08Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
23.08Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
23.08Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
23.08Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
23.08Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
23.08Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
23.08Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
23.08Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
23.08Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
23.08Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
23.08Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
23.08Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
23.08Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
23.08Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
23.08Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
23.08Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
23.08Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
23.08Consensusa2_onOrthosteric Liganda2b_on
23.08Consensusa2_on_gpOrthosteric Liganda2b_on_gp
23.08Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
23.08Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
23.08Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
23.08Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
23.08Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
23.08Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
23.08Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
23.08Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
23.08Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
23.08Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
23.08Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
23.08Consensuspth_onOrthosteric Ligandpth1_on pth2_on
22.86Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
22.86Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
22.86Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
22.86Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
22.73Single4O9RCyclopamine4O9R-SMO-Cyclopamine
22.73Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
22.73Single7XP6Strychnine7XP6-TAS2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
22.73Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
22.73Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
22.73Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
22.73Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
22.73Single8K5BNiacin8K5B-HCA2-Niacin
22.73Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab
22.73Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
22.73Single9B9Y7DY9B9Y-CB1-7DY
22.73Single9E7RGB889E7R-PAR2-GB88-chim(NtGi1L-Gs-CtGq)/β1/γ2
22.73Single9IZDCHBA9IZD-HCA1-CHBA-Gi1/β1/γ2
22.73Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
22.58Single6W25SHU91196W25-MC4-SHU9119-Ca
22.58Single8W8YGamma-MSH8W8Y-MC3-γ-MSH-Ca-Gs/β1/γ2
22.58Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
22.58Consensusclass-b1_class-b2_cons_onOrthosteric Ligandclass-b1_on class-b2_on
22.58Consensusclass-b1_class-b2_cons_on_gpOrthosteric Ligandclass-b1_on_gp class-b2_on_gp
22.22Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
22.22Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
22.22Single4AMIBucindolol4AMI-β1-Bucindolol
22.22Single4N4WSANT-14N4W-SMO-SANT-1
22.22Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
22.22Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
22.22Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
22.22Single6KQICP559406KQI-CB1-CP55940-Org27569
22.22Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
22.22Single6ZG4HTL00099366ZG4-M1-HTL0009936
22.22Single7DFPSpiperone7DFP-D2-Spiperone
22.22Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
22.22Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
22.22Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
22.22Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
22.22Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
22.22Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
22.22Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
22.22Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
22.22Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
22.22Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.22Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
22.22Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
22.22Single8XYIVUF106618XYI-CXCR3-VUF10661
22.22Single9BJKNAM9BJK-μ-Naloxone-NAM
22.22Single9EBIPiclidenoson9EBI-A3A-Piclidenoson-chim(NtGi1L-Gs-CtGi1)/β1/γ2
22.22Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
22.22Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
22.22Consensusalpha1_offOrthosteric Ligandalpha1a_off
22.22Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
22.22Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
22.22Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
22.22Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
22.22Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
22.22Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
22.22Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
22.22Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
22.22Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
22.22Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
21.95Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
21.95Consensusclass-b1_onOrthosteric Ligandglucagon_on vip-pacap_on pth_on crf_on calcitonin_on
21.88Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
21.88Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
21.88Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
21.88Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
21.88Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
21.88Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ2
21.88Single9EBOGLP-1 (ACPC18)9EBO-GLP-1-GLP-1 (ACPC18)-Gs/β1/γ2
21.74Single4QINSAG1.54QIN-SMO-SAG1.5
21.74Single5ZKQABT-4915ZKQ-PAF-ABT-491
21.74Single6AKXA4R6AKX-CCR5-A4R
21.74Single6AKYMaraviroc6AKY-CCR5-Maraviroc
21.74Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
21.74Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
21.74Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
21.74Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
21.74Single6TODEMPA6TOD-OX1-EMPA-Na
21.74Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
21.74Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
21.74Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
21.74Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
21.74Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
21.74Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
21.74Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
21.74Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
21.74Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
21.74Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
21.74Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
21.74Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
21.74Single8U4PAMD31008U4P-CXCR4-AMD3100-Gi1/β1/γ2
21.74Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
21.74Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
21.74Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
21.74Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
21.74Single8Y0HVUF114188Y0H-CXCR3-VUF11418
21.74Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go/β1/γ2
21.74Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
21.74Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
21.74Single9EBHAdenosine9EBH-A3A-Adenosine-Gi1/β1/γ2
21.74Single9KPESA09KPE-TAS2R16-SA0-Gi1/β1/γ2
21.74Consensusalpha2_offOrthosteric Ligandalpha2c_off
21.74Consensusangiotensin_offOrthosteric Ligandat1_off
21.74Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
21.74Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
21.74Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
21.74Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
21.74Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
21.74Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
21.62Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
21.62Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
21.62Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
21.62Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
21.43Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
21.43Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
21.43Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
21.43Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
21.43Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
21.43Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
21.43Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
21.43Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
21.43Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
21.43Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
21.43Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Single8S2TIsoprenaline8S2T-β1-Isoprenaline-chim(NtGi1-Gs)/β1/γ2
21.43Single8T3OTUG-8918T3O-FFA4-TUG-891-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.43Single9AS02-bromo-LSD9AS0-5-HT2A-2-bromo-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Single9C0KExendin-49C0K-GLP-1-Exendin-4-Gs/β1/γ2
21.43Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
21.21Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
21.21Consensuscalcitonin_onOrthosteric Ligandctlike_on
21.21Consensusvpac_onOrthosteric Ligandvpac1_on vpac2_on
21.05Single5MZPCaffeine5MZP-A2A-Caffeine-Na
21.05Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
21.05Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
20.93Consensuspth_on_gpOrthosteric Ligandpth1_on_gp pth2_on_gp
20.83Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
20.83Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
20.83Single6KUXRS-799486KUX-α2a-RS-79948
20.83Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
20.83Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
20.83Single6PS0S-Carazolol6PS0-β2-S-Carazolol
20.83Single6PS4ICI118-5516PS4-β2-ICI118-551
20.83Single6PS5S-Propranolol6PS5-β2-S-Propranolol
20.83Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
20.83Single6TPKRetosiban6TPK-OT-Retosiban
20.83Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
20.83Single6ZG9GSK10347026ZG9-M1-GSK1034702
20.83Single7UL3Famotidine7UL3-H2-Famotidine
20.83Single7VV6C48/807VV6-MRGPRX2-C48/80
20.83Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
20.83Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
20.83Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
20.83Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.83Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.83Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
20.83Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
20.83Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
20.83Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
20.83Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
20.83Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
20.83Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
20.83Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
20.83Single8K2WAMG4878K2W-CXCR3-AMG487
20.83Single8K9LDamgo8K9L-μ-Damgo-BMS-986122-Gi3/β1/γ1
20.83Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.83Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.83Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.83Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.83Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
20.83Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
20.83Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
20.83Single8ZPNAMD31008ZPN-CXCR4-AMD3100
20.83Single9AS5Mescaline9AS5-5-HT2A-Mescaline
20.83Single9AS6Mescaline9AS6-5-HT2A-Mescaline-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
20.83Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
20.83Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
20.83Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
20.83Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
20.83Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
20.83Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
20.83Consensusvasop-oxy_offOrthosteric Ligandot_off
20.69Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
20.69Single7SK9CCX6627SK9-ACKR3-CCX662
20.69Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
20.69Single9JF4PD1683689JF4-BB1-PD168368
20.69Single9MD1Buspirone9MD1-5-HT1A-Buspirone-Gz/β1/γ2
20.59Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
20.59Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
20.59Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
20.59Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
20.59Single9BLWCagrilintide backbone (non-acylated)9BLW-CT (AMY1)-Cagrilintide backbone (non-acylated)-Gs/β1/γ2; RAMP1
20.59Single9BP3Cagrilintide9BP3-CT (AMY1)-Cagrilintide-Gs/β1/γ2; RAMP1
20.59Consensuscalcitonin_on_gpOrthosteric Ligandctlike_on_gp
20.59Consensusvpac1_on_gpOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
20.59Consensusvpac_on_gpOrthosteric Ligandvpac1_on_gp vpac2_on_gp
20.51Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
20.51Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
20.51Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
20.51Consensusglucagon_onOrthosteric Ligandglp_on gluc_on secretin_on gip_on
20.00Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
20.00Single2Y01Dobutamine2Y01-β1-Dobutamine
20.00Single2Y04Salbutamol2Y04-β1-Salbutamol
20.00Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
20.00Single3NY8ICI118-5513NY8-β2-ICI118-551
20.00Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
20.00Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
20.00Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
20.00Single4GBRS-Carazolol4GBR-β2-S-Carazolol
20.00Single4QKX35V4QKX-β2-35V
20.00Single5DHGC-355DHG-NOP-C-35
20.00Single5DHHSB-6121115DHH-NOP-SB-612111
20.00Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
20.00Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
20.00Single6DRXLisuride6DRX-5-HT2B-Lisuride
20.00Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
20.00Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
20.00Single6GPSMK08126GPS-CCR2-MK0812
20.00Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/β1/γ2
20.00Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
20.00Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
20.00Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
20.00Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
20.00Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
20.00Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
20.00Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
20.00Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
20.00Single7F83PF-051904577F83-Ghrelin-PF-05190457
20.00Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
20.00Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
20.00Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
20.00Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
20.00Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
20.00Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
20.00Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
20.00Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
20.00Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
20.00Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
20.00Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
20.00Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
20.00Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
20.00Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
20.00Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
20.00Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
20.00Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
20.00Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
20.00Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
20.00Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
20.00Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
20.00Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
20.00Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
20.00Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
20.00Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
20.00Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
20.00Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
20.00Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
20.00Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
20.00Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
20.00Single8JJOAlprenolol8JJO-β2-Alprenolol
20.00Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
20.00Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
20.00Single8KIGSHU91198KIG-MC3-SHU9119-Ca
20.00Single8PJKST1718PJK-5-HT1A-ST171-Gi1/β1/γ1
20.00Single8T1WCVN4248T1W-GPR6-CVN424
20.00Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
20.00Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
20.00Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
20.00Single8YWFRetatrutide8YWF-GLP-1-Retatrutide-chim(NtGi1-Gs)/β1/γ2
20.00Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
20.00Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
20.00Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
20.00Single9BUCCagrilintide9BUC-CT-Cagrilintide-Gs/β1/γ2
20.00Single9BUECagrilintide9BUE-CT-Cagrilintide-Gs/β1/γ2
20.00Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
20.00Single9IMATalquetamab9IMA-GPRC5D-Talquetamab
20.00Single9M4TSilodosin9M4T-Alpha1A-Silodosin
20.00Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
20.00Consensus5ht5_onOrthosteric Ligand5ht5a_on
20.00Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
20.00Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
20.00Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
20.00Consensusclass-b1_on_gpOrthosteric Ligandglucagon_on_gp vip-pacap_on_gp pth_on_gp crf_on_gp calcitonin_on_gp
20.00Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
20.00Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
20.00Consensusdopamine_offOrthosteric Ligandd2_off d3_off
20.00Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
20.00Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
20.00Consensusglucagon_on_gpOrthosteric Ligandglp_on_gp gluc_on_gp secretin_on_gp gip_on_gp
19.44Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
19.44Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
19.44Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
19.44Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
19.44Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
19.44Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
19.44Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
19.44Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
19.44Consensuspth1_onOrthosteric Ligand6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
19.44Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
19.44Consensusvpac2_on_gpOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
19.35Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
19.23Single2RH1S-Carazolol2RH1-β2-S-Carazolol
19.23Single2Y03Isoprenaline2Y03-β1-Isoprenaline
19.23Single2YCWS-Carazolol2YCW-β1-S-Carazolol
19.23Single5D6LS-Carazolol5D6L-β2-S-Carazolol
19.23Single5JQHS-Carazolol5JQH-β2-S-Carazolol
19.23Single5T1ABMS-6815T1A-CCR2-BMS-681-PubChem 12093170
19.23Single5TVNLSD5TVN-5-HT2B-LSD
19.23Single5WIUNemonapride5WIU-D4-Nemonapride
19.23Single5WIVNemonapride5WIV-D4-Nemonapride-Na
19.23Single5X7DS-Carazolol5X7D-β2-S-Carazolol-Cmpd-15
19.23Single5XPRBosentan5XPR-ETB-Bosentan
19.23Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
19.23Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
19.23Single6GPXMK08126GPX-CCR2-MK0812
19.23Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
19.23Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
19.23Single6LUQHaloperidol6LUQ-D2-Haloperidol
19.23Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
19.23Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
19.23Single6PS6Timolol6PS6-β2-Timolol
19.23Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
19.23Single7C4SS1P7C4S-S1P3-S1P
19.23Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
19.23Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
19.23Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
19.23Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
19.23Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
19.23Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
19.23Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.23Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.23Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
19.23Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
19.23Single8XYKVUF106618XYK-CXCR3-VUF10661-Go/β1/γ2
19.23Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
19.23Single9GE2ML1849GE2-GPR55-ML184-chim(NtGi1-G13)/β1/γ2
19.23Single9K07DSO-5a9K07-BB3-DSO-5a-chim(NtGi2L-Gs-CtGq)/β1/γ2
19.23Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
19.23Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
19.23Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
19.23Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
19.23Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
19.23Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
19.23Consensusamine_offonOrthosteric Ligandamine_off amine_on
19.23Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
19.23Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
19.23Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
19.23Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
19.23Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
19.23Consensusep_offOrthosteric Ligandep4_off
19.23Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
19.23Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
19.23Consensustrace-amine_onOrthosteric Ligandta1_on
19.05Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
19.05Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
19.05Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
19.05Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
19.05Single9EE9Adenosine9EE9-A2A-Adenosine-Gs/β1/γ2
19.05Consensusp2y_offOrthosteric Ligandp2y1_off
18.92Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
18.92Single7RBTTirzepatide7RBT-GIP-Tirzepatide-LSN3556672-chim(NtGi1-Gs)/β1/γ2
18.92Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
18.92Consensusgip_onOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
18.92Consensusgip_on_gpOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
18.75Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
18.75Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
18.75Single9B5YLong-Acting PTH9B5Y-PTH1-Long-Acting PTH-chim(NtGi1-Gq)/β1/γ2
18.60Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
18.52Single4DJHJDTic4DJH-κ-JDTic
18.52Single5D5AS-Carazolol5D5A-β2-S-Carazolol
18.52Single5D5BS-Carazolol5D5B-β2-S-Carazolol
18.52Single5TZRMK86665TZR-FFA1-MK8666
18.52Single5XR8AM8415XR8-CB1-AM841
18.52Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
18.52Single6E59L-7607356E59-NK1-L-760735
18.52Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
18.52Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
18.52Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
18.52Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
18.52Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
18.52Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
18.52Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
18.52Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
18.52Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
18.52Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
18.52Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
18.52Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
18.52Single9BJKNaloxone9BJK-μ-Naloxone-NAM
18.52Single9EGOYVF9EGO-CB1-YVF-Gi1/β1/γ2
18.52Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
18.52Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
18.52Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
18.52Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
18.52Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
18.52Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
18.52Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
18.52Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
18.52Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
18.52Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
18.52Consensustachykinin_offOrthosteric Ligandnk1_off
18.52Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
18.42Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
18.18Single3UZAGTPL92363UZA-A2A-GTPL9236
18.18Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
18.18Single6ME5Agomelatine6ME5-MT1-Agomelatine
18.18Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
18.18Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
18.18Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
18.18Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
18.18Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
18.18Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
18.18Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
18.18Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
18.18Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
18.18Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
18.18Single9BLCCagrilintide backbone (non-acylated)9BLC-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
18.18Consensus5ht2_onOrthosteric Ligand5ht2b_on
18.18Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.95Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
17.95Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
17.95Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
17.95Consensuspth1_on_gpOrthosteric Ligand6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
17.86Single3D4STimolol3D4S-β2-Timolol
17.86Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
17.86Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
17.86Single5TZYMK8666; AP85TZY-FFA1-MK8666; AP8
17.86Single5X33BIIL2605X33-BLT1-BIIL260
17.86Single6CM4Risperidone6CM4-D2-Risperidone
17.86Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
17.86Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
17.86Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
17.86Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
17.86Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
17.86Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
17.86Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
17.86Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
17.86Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
17.86Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
17.86Single8Y6WTUG-13758Y6W-FFA2-TUG-1375-4-CMTB-Gi1/β1/γ2
17.86Single9DGIZ85267113509DGI-CB1-Z8526711350
17.86Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
17.86Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
17.86Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
17.86Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
17.65Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
17.65Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
17.65Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
17.65Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
17.65Consensusvpac1_onOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
17.39Single3PBLEticlopride3PBL-D3-Eticlopride
17.39Single5L7IVismodegib5L7I-SMO-Vismodegib
17.39Single6HLLCP999946HLL-NK1-CP99994
17.39Single6LI0C176LI0-GPR52-C17
17.39Single6TP4ACT-4622066TP4-OX1-ACT-462206
17.39Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
17.39Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
17.39Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
17.39Single7SRQLSD7SRQ-5-HT2B-LSD
17.39Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
17.39Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
17.39Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
17.39Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
17.39Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
17.39Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
17.39Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.39Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
17.39Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
17.39Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
17.39Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
17.39Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
17.39Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
17.24Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
17.24Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
17.24Single6K1QIRL25006K1Q-ETB-IRL2500
17.24Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
17.24Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
17.24Single7UM4AS26747237UM4-5-HT5A-AS2674723
17.24Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
17.24Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
17.24Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
17.24Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
17.24Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
17.24Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
17.24Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
17.24Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
17.24Single9DYEBuspirone9DYE-5-HT1A-Buspirone-Go/β1/γ2
17.24Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
17.24Consensusfp-alpha_onOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
17.24Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
17.14Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
17.14Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
17.14Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
17.14Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
17.14Single9BLBCagrilintide backbone (non-acylated)9BLB-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
17.14Consensussecretin_onOrthosteric Ligand7D3S-Secretin-Secretin-Gs/β1/γ2
16.67Single5U09Taranabant5U09-CB1-Taranabant
16.67Single6B73MP11046B73-κ-MP1104
16.67Single6ME9Ramelteon6ME9-MT2-Ramelteon
16.67Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
16.67Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
16.67Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
16.67Single6PT3DPI-2876PT3-δ-DPI-287
16.67Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
16.67Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
16.67Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
16.67Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
16.67Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
16.67Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
16.67Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
16.67Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
16.67Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
16.67Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
16.67Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
16.67Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
16.67Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
16.67Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
16.67Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
16.67Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
16.67Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.67Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
16.67Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
16.67Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
16.67Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
16.67Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
16.67Single8IWESpermidine8IWE-TA9-Spermidine
16.67Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
16.67Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
16.67Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
16.67Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
16.67Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
16.67Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
16.67Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
16.67Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
16.67Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
16.67Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
16.67Single9CGKC5-Quino9CGK-δ-C5-Quino-Gi1/β1/γ2
16.67Single9K6LSA09K6L-TAS2R16-SA0-Gi2/β1/γ2
16.67Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
16.67Single9NS9TUG-13759NS9-FFA2-TUG-1375-Compound 187-Gi1/β1/γ2
16.67Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
16.67Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
16.67Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
16.67Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
16.67Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
16.67Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
16.67Consensussecretin_on_gpOrthosteric Ligand7D3S-Secretin-Secretin-Gs/β1/γ2
16.28Consensuspth2_on_gpOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
16.22Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
16.22Single9BQ3Cagrilintide9BQ3-CT (AMY2)-Cagrilintide-Gs/β1/γ2; RAMP2
16.13Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
16.13Single7QA8Peptide7QA8-STE2-Peptide
16.13Single7QA8Peptide7QA8-STE2-Peptide
16.13Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
16.13Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.13Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
16.13Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
16.00Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
16.00Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
16.00Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
16.00Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
16.00Single6TPNHTL66416TPN-OX2-HTL6641
16.00Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
16.00Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
16.00Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
16.00Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
16.00Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
16.00Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
16.00Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
16.00Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
16.00Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
16.00Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.00Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
16.00Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
16.00Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
16.00Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
16.00Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
16.00Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
16.00Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
16.00Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.00Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
16.00Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
16.00Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
16.00Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
16.00Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
16.00Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
16.00Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
16.00Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.00Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
16.00Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
16.00Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
16.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
16.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.00Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
16.00Single8YRGFospropofol8YRG-MRGPRX4-Fospropofol-chim(NtGi1-Gs-CtGq)/β1/γ2
16.00Single9AS3LSD9AS3-5-HT2A-LSD
16.00Single9AS4LSD9AS4-5-HT2A-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
16.00Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
16.00Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
16.00Single9IXXLTD49IXX-CysLT2-LTD4-chim(NtGi1-Gs-CtGq)/β1/γ2
16.00Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Gi1/β1/γ2
16.00Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
16.00Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
16.00Consensusalpha1_onOrthosteric Ligandalpha1a_on
16.00Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
16.00Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
16.00Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
16.00Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
16.00Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
15.62Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
15.62Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
15.38Single4EJ4Naltrindole4EJ4-δ-Naltrindole
15.38Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
15.38Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
15.38Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
15.38Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
15.38Single6H7MSalbutamol6H7M-β1-Salbutamol
15.38Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
15.38Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
15.38Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
15.38Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
15.38Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
15.38Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
15.38Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
15.38Single7WC7Lisuride7WC7-5-HT2A-Lisuride
15.38Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
15.38Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
15.38Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
15.38Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
15.38Single8JXRLSD8JXR-D1-LSD
15.38Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
15.38Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
15.38Single8X63Mepyramine8X63-H1-Mepyramine
15.38Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
15.38Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
15.38Single9AS1DMT9AS1-5-HT2A-DMT
15.38Single9AUCCalcitonin gene-related peptide-19AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
15.38Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
15.38Single9IYAONO-97105319IYA-GPR55-ONO-9710531
15.38Single9PLNN-(5-methylnaphthalen-1-yl)pyridin-4-amine9PLN-α2a-N-(5-methylnaphthalen-1-yl)pyridin-4-amine
15.38Single9PLON-(5-methylnaphthalen-1-yl)pyridin-4-amine9PLO-α2a-N-(5-methylnaphthalen-1-yl)pyridin-4-amine-Go/β1/γ2
15.38Single9PQD(6m)-1-methyl-6-(1,2,5,6-tetrahydropyridin-3-yl)-1h-indole9PQD-α2a-(6m)-1-methyl-6-(1,2,5,6-tetrahydropyridin-3-yl)-1h-indole
15.38Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
15.38Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
15.38Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
15.38Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
15.38Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
15.38Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
15.38Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
15.38Consensusalpha2_onOrthosteric Ligandalpha2b_on
15.38Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
15.38Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
15.38Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
15.38Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
15.38Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
15.38Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
15.38Consensushistamine_offOrthosteric Ligandh1_off
15.38Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
15.15Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
15.15Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
15.00Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
15.00Single8GEJConstrained Epinephrine8GEJ-β2-Constrained Epinephrine-Gs/β1/γ2
15.00Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
15.00Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
14.81Single4NTJAZD12834NTJ-P2Y12-AZD1283
14.81Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
14.81Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
14.81Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
14.81Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
14.81Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
14.81Single7WC6LSD7WC6-5-HT2A-LSD
14.81Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
14.81Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
14.81Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
14.81Single9ARYSerotonin9ARY-5-HT2A-Serotonin-chim(NtGi1-Gs-CtGq)/β1/γ2
14.81Single9ARZ2-bromo-LSD9ARZ-5-HT2A-2-bromo-LSD
14.81Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
14.81Single9F33FOB02-04A9F33-D3-FOB02-04A-Go/β1/γ2
14.81Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
14.81Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
14.81Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
14.81Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
14.81Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
14.81Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
14.81Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
14.71Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
14.71Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
14.71Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
14.71Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
14.71Single9BUDCagrilintide9BUD-CT-Cagrilintide-Gs/β1/γ2
14.71Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
14.63Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
14.63Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
14.63Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
14.29Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
14.29Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
14.29Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
14.29Single7WC4Serotonin7WC4-5-HT2A-Serotonin
14.29Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
14.29Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
14.29Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
14.29Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
14.29Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
14.29Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
14.29Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
14.29Single8ZW0PGD28ZW0-DP1-PGD2-Gs/β1/γ2
14.29Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
14.29Consensusgluc_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
14.29Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
14.29Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
13.95Consensusgluc_on_gpOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
13.89Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
13.89Single9BUBCagrilintide9BUB-CT-Cagrilintide-Gs/β1/γ2
13.89Consensuscrf2_on_gpOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
13.89Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
13.79Single4PY02MeSATP4PY0-P2Y12-2MeSATP
13.79Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
13.79Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
13.79Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
13.79Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.79Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.79Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
13.79Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
13.79Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
13.79Single9CM3TUG-13759CM3-FFA2-TUG-1375-Compound 187-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.79Single9GGGI-BOP9GGG-TXA2-I-BOP-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.79Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
13.79Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
13.79Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
13.64Single6TQ9SB-4081246TQ9-OX1-SB-408124
13.64Single6XBM5LWE6XBM-SMO-5LWE-Gi1/β1/γ2
13.64Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
13.64Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
13.64Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.64Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Gi1/β1/γ2
13.64Single8WC5Tetramethylammonium Ion8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
13.64Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
13.64Single9CHUNoradrenaline9CHU-β2-Noradrenaline
13.64Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
13.64Consensussensory_onOrthosteric Ligandopsins_on
13.51Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
13.51Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
13.51Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
13.51Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
13.51Consensusglp2_on_gpOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
13.33Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
13.33Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
13.33Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.33Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
13.33Single9CGJC6-Quino9CGJ-δ-C6-Quino-Gi1/β1/γ2
13.33Single9GG5U466199GG5-TXA2-U46619-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.33Single9M1HProstaglandin E29M1H-EP1-Prostaglandin E2-chim(NtGi1-Gs-CtGq)/β1/γ2
13.33Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
13.16Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
13.16Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
13.16Single9BTWCagrilintide9BTW-CT (AMY3)-Cagrilintide-Gs/β1/γ2; RAMP3
13.16Consensusctlike_on_gpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
13.04Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
13.04Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
13.04Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
13.04Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
13.04Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
13.04Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
13.04Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
13.04Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
13.04Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
13.04Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
13.04Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
13.04Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
13.04Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
13.04Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
13.04Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
13.04Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
13.04Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
13.04Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
13.04Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
13.04Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
13.04Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
13.04Single9JHJC18:0 Ceramide9JHJ-FPR2-ALX-C18:0 Ceramide-Gi1/β1/γ2
13.04Single9LRCHistamine9LRC-H4-Histamine
13.04Single9LREHistamine9LRE-H4-Histamine-Gi1/β1/γ2
13.04Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
13.04Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
13.04Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
13.04Consensusgi_sensoryOrthosteric Ligandgi_opsins
13.04Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
13.04Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
13.04Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
13.04Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
13.04Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
13.04Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
13.04Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
12.90Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
12.90Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
12.90Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
12.90Single9CM7TUG-13759CM7-FFA2-TUG-1375-AZ-1729-Gi1/β1/γ2
12.50Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
12.50Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
12.50Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
12.50Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
12.50Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
12.50Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
12.50Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
12.50Single7UL2SR486927UL2-NTS1-SR48692-Na
12.50Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
12.50Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
12.50Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
12.50Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
12.50Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
12.50Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
12.50Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
12.50Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
12.50Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
12.50Single8YN7Immethridine8YN7-H3-Immethridine-Go/β1/γ2
12.50Single9AS2DMT9AS2-5-HT2A-DMT-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
12.50Single9IXJHistamine9IXJ-H2-Histamine-Gs/β1/γ2
12.50Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg4_on
12.50Consensusadgrg_on_gpOrthosteric Ligandadgrg2_on_gp adgrg4_on_gp
12.50Consensusneurotensin_offOrthosteric Ligandnts1_off
12.50Consensusnts1_offOrthosteric Ligand7UL2-NTS1-SR48692-Na
12.00Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
12.00Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
12.00Single6ME2Ramelteon6ME2-MT1-Ramelteon
12.00Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
12.00Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
12.00Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
12.00Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
12.00Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
12.00Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
12.00Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
12.00Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
12.00Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.00Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
12.00Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
12.00Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ2
12.00Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
12.00Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
12.00Single9LRBHistamine9LRB-H1-Histamine-Gs/β1/γ2
12.00Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
12.00Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
12.00Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
12.00Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
12.00Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
12.00Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
12.00Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
12.00Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
11.54Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
11.54Single3RZECidoxepin3RZE-H1-Cidoxepin
11.54Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
11.54Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
11.54Single6A94Zotepine6A94-5-HT2A-Zotepine
11.54Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
11.54Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
11.54Single6VI4JDTic6VI4-κ-JDTic
11.54Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
11.54Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
11.54Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
11.54Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
11.54Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
11.54Single7T94Acetylcholine7T94-M2-Acetylcholine-LY2119620-chim(NtGi1-Go)/β1/γ2
11.54Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
11.54Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
11.54Single7VODCariprazine7VOD-5-HT2A-Cariprazine
11.54Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
11.54Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ2
11.54Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
11.54Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
11.54Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
11.54Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.54Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
11.54Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
11.54Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
11.54Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
11.54Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
11.54Single9ARXSerotonin9ARX-5-HT2A-Serotonin
11.54Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
11.54Single9LRDHistamine9LRD-H1-Histamine-Gi1/β1/γ2
11.54Consensusopsins_offOrthosteric Ligandrhodopsin_off
11.54Consensussensory_offOrthosteric Ligandopsins_off
11.43Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
11.11Single4DAJTiotropium4DAJ-M3-Tiotropium
11.11Single4MQSIperoxo4MQS-M2-Iperoxo
11.11Single4U14Tiotropium4U14-M3-Tiotropium
11.11Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
11.11Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
11.11Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
11.11Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
11.11Single6IIVDaltroban6IIV-TXA2-Daltroban
11.11Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.11Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
11.11Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
11.11Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
11.11Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
11.11Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
11.11Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
11.11Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
11.11Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
11.11Single8X64Desloratadine8X64-H1-Desloratadine
11.11Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
11.11Single8YN8Proxyfan8YN8-H3-Proxyfan-Go/β1/γ2
11.11Single9IVGGLP-1 (Truncated)9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
11.11Single9JEAAtropine9JEA-M1-Atropine
11.11Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
11.11Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
11.11Consensusblt_onOrthosteric Ligandblt1_on
11.11Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
11.11Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
11.11Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
11.11Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
11.11Consensusleukotriene_onOrthosteric Ligandblt_on
11.11Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
11.11Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
11.11Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
10.71Single5CGCHTL142425CGC-mGlu5-HTL14242
10.71Single6HLPNetupitant6HLP-NK1-Netupitant
10.71Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
10.71Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
10.71Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
10.71Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
10.71Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.71Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
10.71Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
10.71Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
10.71Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
10.71Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
10.71Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
10.71Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
10.71Single8ZMFA1L108ZMF-5-HT2C-A1L10
10.71Single9DYDAsenapine9DYD-5-HT1A-Asenapine-Go/β1/γ2
10.71Single9DYFAsenapine9DYF-5-HT1A-Asenapine-Gi1/β1/γ2
10.71Consensusadgrg2_onOrthosteric Ligand7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
10.71Consensusadgrg2_on_gpOrthosteric Ligand7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
10.71Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
10.71Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
10.71Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
10.71Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.71Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.34Single4U15Tiotropium4U15-M3-Tiotropium
10.34Single5V54Methiothepin5V54-5-HT1B-Methiothepin
10.34Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
10.34Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
10.34Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
10.34Single6OL9Tiotropium6OL9-M5-Tiotropium
10.34Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
10.34Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
10.34Single8EA0Iperoxo8EA0-M3-Iperoxo
10.34Single8GDBPGE28GDB-EP4-PGE2-Gs/β1/γ2
10.34Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
10.34Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
10.34Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
10.34Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
10.34Single8YNTSNAP-948478YNT-MCH1-SNAP-94847
10.34Single9CLWTUG-13759CLW-FFA2-TUG-1375-4-CMTB-chim(NtGi1L-Gs-CtGq)/β1/γ2
10.34Consensus5ht1_offOrthosteric Ligand5ht1b_off
10.34Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
10.34Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
10.34Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
10.34Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
10.34Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
10.34Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
10.00Single5CXVTiotropium5CXV-M1-Tiotropium
10.00Single6IIURamatroban6IIU-TXA2-Ramatroban
10.00Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
10.00Single8JD3JNJ-404118138JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
10.00Single8XJNCloprosetnol8XJN-TXA2-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Single9AU0BW245C9AU0-DP1-BW245C-Gs/β1/γ2
10.00Consensuscrf1_onOrthosteric Ligand6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF1-Corticoliberin-Gs/β1/γ2
10.00Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
9.68Single5CGDHTL142425CGD-mGlu5-HTL14242
9.68Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
9.68Single8XJOU466198XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
9.68Single8XVJMacitentan8XVJ-ETA-Macitentan
9.68Single9JH5C16:0 Ceramide9JH5-CysLT2-C16:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
9.68Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
9.68Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
9.68Consensustp_onOrthosteric Ligand8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
9.68Consensustp_on_gpOrthosteric Ligand8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
9.52Consensuscrf1_on_gpOrthosteric Ligand6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF1-Corticoliberin-Gs/β1/γ2
9.38Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
9.38Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
9.38Single9JH6C20:0 Ceramide9JH6-CysLT2-C20:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single3PXOAll-trans-Retinal3PXO-Rhodopsin-All-trans-Retinal
9.09Single5DYSAll-trans-Retinal5DYS-Rhodopsin-All-trans-Retinal
9.09Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
9.09Single7XKDBeta-Hydroxyandrosterone7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
9.09Single8HS2Fab0468HS2-GPR20-Fab046
9.09Single8X9S5alpha-DHT8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
9.09Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
8.70Single6OY9All-trans-Retinal6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
8.70Single8IWM2-Phenylethylamine8IWM-TA9-2-Phenylethylamine
8.70Single8Y02Retinal8Y02-OPN1SW-Retinal-Gi1/β1/γ2
8.70Consensusgs_histamineOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
8.70Consensush2_onOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
8.33Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
8.33Single3PQRAll-trans-Retinal3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
8.33Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.33Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
8.33Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
8.33Single8IW72-Phenylethylamine8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
8.33Single8JPSCCL78JPS-ACKR1-CCL7
8.33Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
8.33Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
8.33Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
8.00Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
8.00Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
8.00Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
8.00Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
8.00Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
8.00Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
8.00Single7V68Iperoxo7V68-M4-Iperoxo-LY2119620-Gi1/β1/γ2
8.00Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
8.00Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
8.00Single8HSCFab0468HSC-GPR20-Fab046-Gi1/β1/γ2
8.00Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
8.00Single8YN2Histamine8YN2-H1-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
8.00Single8ZYUNeurotensin peptide 8-138ZYU-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
8.00Single9AS7Psilocin9AS7-5-HT2A-Psilocin
8.00Single9EPRRetinal9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
8.00Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
8.00Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
7.69Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
7.69Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
7.69Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
7.69Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
7.69Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
7.69Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
7.69Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
7.69Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
7.69Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
7.69Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
7.69Single8T3VDocosa-4,7,10,13,16,19-Hexaenoic acid8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.69Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
7.69Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
7.41Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
7.41Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
7.41Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
7.41Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.41Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
7.41Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
7.41Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
7.41Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
7.41Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
7.14Single5DSGTiotropium5DSG-M4-Tiotropium
7.14Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
7.14Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
6.90Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
6.90Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
6.90Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
6.90Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
6.90Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
6.90Single8ZVZBW245C8ZVZ-DP1-BW245C-Gs/β1/γ2
6.90Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
6.90Single9HC04YI9HC0-mGlu5-4YI
6.67Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
6.67Single7P2L4YI7P2L-mGlu5-4YI
6.67Single8JD5JNJ-40411813; ADX881788JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
6.67Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
6.67Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Gi1/β1/γ1
6.67Single9AS9RS130-1809AS9-5-HT2A-RS130-180
6.67Single9ASARS130-1809ASA-5-HT2A-RS130-180-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
5.26Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
5.26Single6D35Cholesterol6D35-SMO-Cholesterol
5.26Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
5.26Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
5.26Single6UO8SKF975416UO8-GABAB1, GABAB2-SKF97541-GS39783
5.26Single6UO9SKF975416UO9-GABAB1, GABAB2-SKF97541
5.26Single6W2XPubChem 53110426W2X-GABAB1, GABAB2-PubChem 5311042
5.26Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042
5.26Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042
5.26Single7C7QBaclofen7C7Q-GABAB1, GABAB2-Baclofen-BHFF
5.26Single7C7SCGP546267C7S-GABAB1, GABAB2-CGP54626
5.26Single7CUMCGP546267CUM-GABAB1, GABAB2-CGP54626
5.26Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.26Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.26Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.26Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.26Single7DGEQuisqualate7DGE-mGlu1; mGlu1-Quisqualate
5.26Single7DTTCa7DTT-CaS-Ca-Ca
5.26Single7DTTCa7DTT-CaS-Ca-Ca
5.26Single7DTUTryptophan7DTU-CaS-Tryptophan
5.26Single7DTUTryptophan7DTU-CaS-Tryptophan
5.26Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
5.26Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
5.26Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
5.26Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
5.26Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.26Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.26Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.26Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.26Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
5.26Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
5.26Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
5.26Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
5.26Single7EB2Baclofen7EB2-GABAB2; GABAB1-Baclofen-rac-BHFF-Gi1/β1/γ2
5.26Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
5.26Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
5.26Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
5.26Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
5.26Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
5.26Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
5.26Single7FIHhCG7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
5.26Single7FIIhCG7FII-LH-hCG-chim(NtGi1-Gs)/β1/γ2
5.26Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
5.26Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
5.26Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
5.26Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
5.26Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.26Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.26Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.26Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.26Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
5.26Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
5.26Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
5.26Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
5.26Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
5.26Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
5.26Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
5.26Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
5.26Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
5.26Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
5.26Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.26Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.26Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.26Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.26Single7T9NM22 Fab7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
5.26Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
5.26Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
5.26Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
5.26Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
5.26Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
5.26Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
5.26Single7XW6M22 Fab7XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
5.26Single7XW7K1-707XW7-TSH-K1-70
5.26Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
5.26Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
5.26Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
5.26Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
5.26Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
5.26Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
5.26Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
5.26Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
5.26Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
5.26Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
5.26Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
5.26Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
5.26Single8JD0Glutamate8JD0-mGlu2; mGlu3-Glutamate-NAM563
5.26Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
5.26Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
5.26Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
5.26Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
5.26Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
5.26Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
5.26Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
5.26Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
5.26Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
5.26Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
5.26Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
5.26Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
5.26Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
5.26Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
5.26Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
5.26Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
5.26Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
5.26Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
5.26Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
5.26Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
5.26Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
5.26Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
5.26Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
5.26Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
5.26Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
5.26Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
5.26Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
5.26Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
5.26Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
5.26Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
5.26Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
5.26Single8WG9(2S)-2-amino-4-phosphonobutanoic acid8WG9-mGlu4; mGlu2-(2S)-2-amino-4-phosphonobutanoic acid
5.26Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
5.26Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
5.26Single8WGCLY3792688WGC-mGlu4; mGlu2-LY379268
5.26Single8WGDWAG; WA68WGD-mGlu4; mGlu2-WAG; WA6
5.26Single8WGDWAG; WA68WGD-mGlu4; mGlu2-WAG; WA6
5.26Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
5.26Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
5.26Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.26Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.26Single8WVXNorrin8WVX-LGR4-Norrin
5.26Single8WVYNorrin8WVY-LGR4-Norrin
5.26Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
5.26Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
5.26Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
5.26Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
5.26Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
5.26Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
5.26Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
5.26Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
5.26Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
5.26Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
5.26Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
5.26Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
5.26Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
5.26Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
5.26Single8XUMR-spondin-28XUM-LGR4-R-spondin-2
5.26Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
5.26Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
5.26Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
5.26Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
5.26Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
5.26Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
5.26Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
5.26Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
5.26Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
5.26Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
5.26Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
5.26Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
5.26Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
5.26Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
5.26Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
5.26Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
5.26Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
5.26Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
5.26Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
5.26Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
5.26Single9KHHNorrin9KHH-LGR4-Norrin
5.26Single9S37NB219S37-LGR4-NB21
5.26Single9UTBSucralose9UTB-TAS1R2; TAS1R3-Sucralose
5.00Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
5.00Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
5.00Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
5.00Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
5.00Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
5.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
5.00Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
5.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
5.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
5.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
5.00Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
5.00Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
5.00Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
5.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
5.00Consensusclass-b2_onOrthosteric Ligandadgrg_on adgrf_on adgrl_on adgre_on adgrd_on
5.00Consensusclass-b2_on_gpOrthosteric Ligandadgrg_on_gp adgrf_on_gp adgrl_on_gp adgre_on_gp adgrd_on_gp
4.76Single7KNUCalcitonin gene-related peptide-17KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
4.76Single7T9MCS-17 Antibody7T9M-TSH-CS-17 Antibody
4.76Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
4.76Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
4.55Single4A4MAll-trans-Retinal4A4M-Rhodopsin-All-trans-Retinal-Gt(CT)
4.55Single5EN0All-trans-Retinal5EN0-Rhodopsin-All-trans-Retinal-Gt(CT)
4.55Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
4.55Single7FIGhCG7FIG-LH-hCG-chim(NtGi1L-Gs)/β1/γ2
4.55Single7UTZTR14027UTZ-TSH-TR1402-DPPC-Gs/β1/γ2
4.55Single7XW5TSH7XW5-TSH-TSH-ML109-Gs/β1/γ2
4.55Single7ZI0Cholesterol7ZI0-SMO-SAG-Cholesterol
4.55Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/β1/γ2
4.35Single5L7DCholesterol5L7D-SMO-Cholesterol
4.35Single7T9ITSH7T9I-TSH-TSH-Gs/β1/γ2
4.35Single8I2GGlycoprotein hormones alpha chain8I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
4.17Single2HPYAll-trans-Retinal2HPY-Rhodopsin-All-trans-Retinal
4.17Single7Y14Beta-Alanine7Y14-MRGPRD-β-Alanine
4.00Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
4.00Single7Y12Beta-Alanine7Y12-MRGPRD-β-Alanine-Gi1/β1/γ2
4.00Single8J6QCompound 9n8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
3.85Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
3.85Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
3.85Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
3.85Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/β1/γ2
3.85Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
3.57Single6FFIMMPEP6FFI-mGlu5-MMPEP
3.57Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
3.57Single8JD6VU03647708JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
3.45Single6FFHFenobam6FFH-mGlu5-Fenobam
3.33Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
3.23Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
2.86Single8XFTR-spondin-28XFT-LGR4-R-spondin-2-ZNRF3
2.86Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-ZNRF3
2.70Single8WVUR-spondin-18WVU-LGR4-R-spondin-1-RNF43
2.70Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-ZNRF3
2.63Single8XFPR-spondin-28XFP-LGR4-R-spondin-2-ZNRF3
2.44Single8XFSR-spondin-28XFS-LGR4-R-spondin-2-ZNRF3

Consensus Members
Id Members
c5a1_on_gp 8HK5-C5a1-Complement C5-Gi1/β1/γ2
7Y66-C5a1-BM213-Gi1/β1/γ2
7Y67-C5a1-C089 peptide-Gi1/β1/γ2
7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
c3a_on_gp 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
8IA8-C3aB-E7 peptide-Gi1/β1/γ2
Net Summary
Imin 2.6075
Number of Linked Nodes 874
Number of Links 1046
Number of Hubs 154
Number of Links mediated by Hubs 613
Number of Communities 24
Number of Nodes involved in Communities 233
Number of Links involved in Communities 324
Path Summary
Number Of Nodes in MetaPath 92
Number Of Links MetaPath 91
Number of Shortest Paths 4395575
Length Of Smallest Path 3
Average Path Length 35.7988
Length of Longest Path 66
Minimum Path Strength 0.33875
Average Path Strength 5.55424
Maximum Path Strength 31.8081
Minimum Path Correlation 0.70125
Average Path Correlation 0.989259
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.96078
Average % Of Corr. Nodes 32.8441
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 51.8935
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following consensuses:
IdComponents
peptide_on_gpcck_on_gp
angiotensin_on_gp
apelin_on_gp
bombesin_on_gp
bradykinin_on_gp
compl-peptide_on_gp
endothelin_on_gp
formylpeptide_on_gp
galanin_on_gp
ghrelin_on_gp
kisspeptin_on_gp
melanocortin_on_gp
motilin_on_gp
neuromedin-u_on_gp
npy_on_gp
neurotensin_on_gp
opioid_on_gp
orexin_on_gp
relaxin_on_gp
somatostatin_on_gp
tachykinin_on_gp
trh_on_gp
vasop-oxy_on_gp



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Download compl-peptide_on_gp.zip



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