Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
1NT 31.8344935
21x38 8.56875404
31x39 2.356537
41x50 5.421254139
51x60 5.6525405
6I1x50 6.1375407
72x39 3.43568
82x42 5.57875407
92x45 5.7254149
102x50 5.0375409
112x54 3.1825406
122x57 4.25375437
132x60 2.92375437
14E1x50 5.08583638
153x28 4.195435
163x30 4.93436
173x37 5.157536
183x41 6.42167635
193x42 3.1285148
203x50 4.75167669
213x51 6.96125407
22I2x50 6.2754188
23I2x56 5.485467
244x49 3.0395147
254x50 4.65256149
264x56 6.935535
274x59 3.9725437
284x60 8.63125435
29E2 11.75553734
30E2x50 4.715439
31E2x52 3.511534
325x39 7.4075636
335x42 3.09434
345x43 5.73625435
355x46 5.3725434
365x461 5.1925636
375x58 5.80125469
385x62 3.124165
396x30 3.2245167
406x40 5.703568
416x44 5.726254179
426x48 6.4315178
436x51 9.185436
446x61 6.1433
45E3 4.52437832
467x37 3.99125436
477x48 2.43375405
487x49 3.53469
497x52 3.30125468
507x53 7.01167669
517x54 5.106254137
528x50 7.7415138
53Lig 6.84786700
54G.HN.43 3.03409
55G.S1.02 3.665585
56G.S1.05 5.1025409
57G.S1.06 4.3854209
58G.H1.01 3.33254209
59G.S2.01 4.242528
60G.S2.06 7.23125488
61G.S3.04 7.292527
62G.S3.06 7.17917626
63G.s3h2.03 4.96429
64G.H2.06 5.16917629
65G.H2.07 5.1825629
66G.H2.10 3.401527
67G.h2s4.01 5.495529
68G.S4.02 4.1675428
69G.S4.04 4.685629
70G.s4h3.01 6.86375407
71G.s4h3.03 3.95625408
72G.H3.03 3.625404
73G.H3.08 3.86429
74G.H3.09 6.14875429
75G.H3.13 3.279525
76G.H3.17 6.799504
77G.H3.18 4.99375429
78G.S5.02 3.36625426
79G.S5.03 3.14375409
80G.S5.04 2.989529
81G.S5.05 3.569176159
82G.S5.06 4.3675408
83G.s5hg.01 4.79409
84G.HG.01 5.325405
85G.HG.15 2.8575497
86G.hgh4.02 6.264599
87G.hgh4.05 8.1575497
88G.H4.05 6.10375494
89G.H4.10 9.573597
90G.H4.12 5.79625425
91G.H4.15 5.172528
92G.h4s6.02 4.205527
93G.h4s6.12 4.92674
94G.S6.02 6.72167678
95G.s6h5.01 4.8325159
96G.s6h5.05 5.60875409
97G.H5.08 6.25625488
98G.H5.13 5.635577
99G.H5.17 5.189576
100G.H5.20 3.464198
101G.H5.26 6.00375405
102b.1x10 2.5075401
103b.1x15 3.9407
104b.lh12x2 2.3425408
105b.h2x1 3.7075405
106b.h2x5 3.3654105
107b.lhb1x3 4.426254102
108b.lhb1x6 4.198754103
109b.lhb1x11 3.955404
110b.b1x4 4.66375407
111b.l1x3 5.965749
112b.l1x7 4.2525449
113b.b2x1 7.61375428
114b.b2x5 5.33214747
115b.b3x3 3.47558
116b.l3x1 8.105429
117b.l3x2 5.59833649
118b.b4x3 4.28417657
119b.b4x4 8.29125448
120b.b4x5 2.90667657
121b.b4x6 8.60071749
122b.l4x2 7.9235114
123b.b5x2 5.0775407
124b.b5x3 5.49083649
125b.b5x5 4.86875455
126b.b5x7 5.082557
127b.l5x1 3.12125458
128b.l5x5 6.46571729
129b.b6x5 4.32071756
130b.l6x5 3.60875414
131b.b7x1 6.25125414
132b.b7x2 2.913558
133b.l7x2 3.438529
134b.l7x4 3.995409
135b.b8x3 2.97375416
136b.b8x4 5.011556
137b.l8x3 3.30375403
138b.b9x3 5.22375456
139b.l9x3 6.15125419
140b.l9x6 4.50071728
141b.b10x3 3.4025418
142b.b10x5 4.71125409
143b.l10x1 4.31375413
144b.b11x2 3.45667617
145b.b11x3 2.79375415
146b.b11x4 4.46667619
147b.b11x5 3.22416
148b.b11x6 5.9325419
149b.l11x2 4.732519
150b.b12x2 2.8975417
151b.b12x3 3.42518
152b.b12x5 3.0125416
153b.b12x6 7.6975618
154b.b12x7 4.15375419
155b.l12x1 3.89625416
156b.b13x7 6.1617
157b.l13x3 6.75786719
158b.l13x7 4.061519
159b.b14x3 3.011515
160b.b14x5 3.15125415
161b.b15x1 5.20333619
162b.b15x2 5.50625426
163b.b15x3 3.856519
164b.l15x1 6.69427
165b.l15x2 6.2375419
166b.b16x4 11.8612416
167b.b16x5 4.31875405
168b.b16x6 7.04714718
169b.b17x3 3.5375415
170b.b17x5 7.55125427
171b.b17x7 7.5075428
172b.l17x3 7.19062829
173b.l17x6 6.179529
174b.l17x7 3.99427
175b.b18x3 3.861528
176b.b18x5 3.80417625
177b.l18x1 5.84562816
178b.l18x3 6.309515
179b.b19x2 4.94062826
180b.b19x4 4.22917628
181b.b19x6 6.6925429
182b.l19x1 3.42125429
183b.l19x2 6.859529
184b.b20x2 4.58625426
185b.b20x4 10.3875428
186b.b20x6 5.0975626
187b.b20x7 4.335409
188b.l20x2 5.505619
189b.b21x1 8.486527
190b.b21x2 3.26417606
191b.b21x5 4.591514
192b.b21x7 5.52357715
193b.l21x5 5.81875414
194b.b22x5 5.15333617
195b.l22x5 6.6125109
196b.b23x2 4.155416
197b.b23x3 2.92625447
198b.b23x6 8.83517
199b.b24x4 9.375416
200b.b24x5 1.97625405
201b.b24x6 6.595518
202b.b24x7 6.28254109
203b.l24x2 4.6655106
204b.l24x3 4.0655105
205b.b25x3 5.49625415
206b.l25x3 8.1695129
207b.l25x6 12.5925408
208b.b26x2 3.17875407
209b.b26x3 3.631546
210b.b26x4 3.12625445
211b.b27x1 3.24875446
212b.l27x1 10.6483629
213b.l27x2 7.893754129
214b.b28x4 5.8125126
215b.b28x6 9.653754129
216b.b28x7 4.181254119
217g.h2x11 6.05419
218g.l2x3 3.59375428
219g.l3x4 3.408509
220g.ctx3 2.9525404
221g.ctx9 2.8525117
222G.HN.11 1.64625400
223b.ntx3 2.49400
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
12x65 E2 18.3954.25NoYes344
21x39 2x65 19.42042.72YesNo374
31x39 2x57 23.16612.49YesYes377
42x54 2x57 35.87583.275YesYes067
51x50 2x50 66.17986.06YesYes099
62x50 7x46 42.92916.65YesNo099
72x54 7x46 42.14042.355YesNo069
81x50 7x50 67.6476.52YesNo1399
98x50 I1x50 91.568914.615YesYes087
107x54 8x50 68.37726.39YesYes1378
117x50 7x54 68.13112.54NoYes1397
121x57 I1x50 94.70733.685NoYes077
13I1x48 I1x51 95.33554.335NoNo066
141x57 I1x51 95.12641.94NoNo076
15I1x48 b.l25x4 95.50197.605NoNo065
162x39 G.H5.23 12.02432.38YesNo684
173x50 G.H5.23 12.22656.265YesNo694
187x45 7x49 15.69533.725NoYes099
196x47 7x45 15.45634.385NoNo089
206x47 6x48 14.8325.875NoYes088
216x48 Lig 11.65254.545YesYes080
222x39 G.H5.22 20.83214.075YesNo084
23G.s6h5.02 G.s6h5.05 45.24746.225NoYes079
24G.HG.02 G.s6h5.02 45.88332.335NoNo097
25G.HG.01 G.HG.02 46.51974.84YesNo059
26G.HG.01 G.s4h3.01 26.12354.935YesYes057
27G.S5.06 G.s4h3.01 27.32524.845YesYes087
28G.S5.04 G.S5.06 49.30343.46YesYes098
29G.S4.04 G.S5.04 55.2742.435YesYes299
30G.S1.07 G.S4.04 35.00462.44NoYes299
31G.S1.05 G.S1.07 35.3334.155YesNo099
32G.S1.05 G.h2s4.01 35.56479.74YesYes099
33G.H2.10 G.h2s4.01 31.51273.495YesYes279
34G.H2.10 b.b2x1 52.02044.705YesYes278
35b.b2x1 b.l27x1 61.43775.79YesYes289
36b.b26x1 b.l27x1 78.48265.56NoYes099
37b.b26x1 b.b26x2 78.36853.44NoYes097
38b.b26x2 b.b2x3 67.02134.86YesNo076
39b.b26x4 b.b2x3 59.22093.49YesNo456
40b.b26x3 b.b26x4 67.75713.42YesYes465
41b.b26x3 b.b27x3 1002.21YesNo068
42b.b27x3 b.l25x3 97.86515.48NoYes089
43b.l25x3 b.l27x2 96.22810.715YesYes1299
44b.l25x4 b.l27x2 95.71225.32NoYes059
45G.HG.01 G.S6.05 24.2368.54YesNo055
46G.S5.06 G.S6.05 24.8356.385YesNo085
47G.H5.10 G.S6.02 14.24114.67NoYes068
48G.H5.10 G.S5.03 14.91613.25NoYes069
49G.S5.03 G.S5.05 16.93953.77YesYes099
50G.S5.05 G.s6h5.01 37.32853.24YesYes1599
51G.s6h5.01 G.s6h5.05 39.00854.335YesYes099
528x47 8x50 21.72195.435NoYes088
53b.l1x3 b.l1x7 10.50887.95YesYes499
54b.b26x2 b.l1x7 14.48132.455YesYes079
55b.l3x1 b.l5x5 18.87528.76YesYes299
56G.S4.03 G.S5.05 19.28692.51NoYes079
57G.H3.18 G.S4.02 18.58515.65YesYes298
58G.H3.15 G.H3.18 18.49826.04NoYes089
59G.H3.15 G.H3.17 18.5512.825NoYes084
60G.H3.17 b.l25x6 16.75825YesYes048
61b.l25x6 b.l27x1 25.72821.99YesYes089
62G.S1.06 G.S4.03 11.17594.995YesNo097
63G.H2.04 G.H3.08 39.64716.075NoYes299
64G.H2.04 G.H2.07 40.26474.5NoYes299
65G.H2.10 b.l7x2 11.40872.38YesYes279
66G.HG.15 G.s4h3.03 10.81942.715YesYes078
67G.H4.11 G.HG.15 16.61372.855NoYes087
68G.H4.11 G.H4.15 19.05412.51NoYes088
69G.H3.09 G.H4.15 12.74537.5YesYes298
70G.s3h2.03 b.l7x4 12.63083.96YesYes099
71G.H2.07 G.s3h2.03 45.83288.765YesYes299
72b.b6x1 b.l7x2 19.43992.83NoYes099
73b.b6x1 b.l9x6 19.30545.385NoYes098
74G.H2.06 b.l17x6 18.31186.22YesYes299
75G.H2.06 b.l9x6 36.52392.985YesYes298
76b.b11x6 b.l11x1 24.21772.785YesNo099
77b.l11x1 b.l9x6 24.42874.345NoYes098
78b.l11x2 b.l9x5 11.39762.515YesNo098
79b.l7x4 b.l9x5 11.68723.395YesNo098
80G.H2.06 b.l19x1 17.89642.765YesYes299
81G.S4.02 G.S5.02 18.11042.94YesYes286
82G.H3.06 G.H4.15 10.42235.595NoYes068
83G.H3.13 G.S5.02 10.47922.455YesYes256
84b.b23x3 b.b26x3 46.31682.765YesYes476
85b.b23x3 b.b24x5 46.11062.235YesYes075
86b.b24x5 b.b25x4 46.92990.85YesNo054
87b.b25x4 b.lhb1x6 46.89570.85NoYes043
88b.l22x5 b.lhb1x6 31.12615.885YesYes1093
89b.l22x5 b.lhb1x3 15.25763.76YesYes1092
90b.h2x5 b.lhb1x3 15.3444.56YesYes1052
91b.h2x1 b.h2x5 47.11662.945YesYes055
92b.h2x1 g.h3x8 40.63262.435YesNo054
93b.l18x1 g.h3x8 45.52836.43YesNo064
94b.l18x1 g.h2x8 18.75553.045YesNo065
95b.1x5 g.h2x8 14.39472.325NoNo035
96b.1x4 b.1x5 11.67393.645NoNo083
97b.l22x5 b.l24x2 15.678712.755YesYes1096
98b.h2x5 b.l24x2 15.99492.95YesYes1056
99b.b24x7 b.lhb1x6 15.72787.3YesYes1093
100b.b24x7 b.l24x3 15.44664.84YesYes1095
101b.h2x5 b.l24x3 15.78043.005YesYes1055
102b.l18x1 b.l18x3 22.34857.25YesYes165
103b.l18x3 b.l18x4 26.69882.545YesNo057
104b.b18x5 b.l18x4 26.77983.01YesNo057
105b.b18x5 b.b19x2 22.1174.285YesYes256
106b.b17x7 b.b19x2 13.73176.965YesYes286
107b.b17x7 b.b21x1 19.27639.555YesYes287
108b.1x18 b.b21x1 11.46945.955NoYes047
109b.l23x1 b.l25x6 37.226921.44NoYes068
110b.l21x7 b.l23x1 37.03593.11NoNo056
111b.l21x7 b.l23x2 36.66486.22NoNo058
112b.b23x6 b.l23x2 35.78974.025YesNo078
113b.b23x6 b.l21x9 11.247110.275YesNo076
114b.b19x5 b.l21x9 11.86372.645NoNo056
115b.b19x4 b.b19x5 11.9032.73YesNo085
116b.b19x2 b.b19x4 14.4772.59YesYes268
117b.b17x7 b.b20x6 13.93535.895YesYes286
118b.1x19 g.l2x3 11.29713.73NoYes068
119b.1x15 b.1x19 10.03272.505YesNo076
120b.l5x3 b.l5x5 35.37822.475NoYes089
121b.l5x3 b.l7x3 34.93558.83NoNo089
122b.l7x3 b.l7x5 34.49262.1NoNo096
123b.b9x3 b.l7x5 33.60595.465YesNo066
124b.b8x2 b.b9x3 16.35413.595NoYes086
125b.b8x2 b.b8x4 15.90475.725NoYes086
126b.b4x3 b.b8x4 16.36413.515YesYes576
127b.b9x3 b.l8x10 16.3544.275YesNo564
128b.b8x4 b.l8x10 15.90965.05YesNo564
129b.b5x7 b.b8x4 10.91177.25YesYes576
130b.b11x6 b.l9x3 22.513511.855YesYes199
131b.b11x4 b.l9x3 14.70754.11YesYes199
132b.b11x2 b.b11x4 13.80233.04YesYes179
133b.b12x6 b.l9x3 18.2484.23YesYes189
134b.b11x2 b.b12x6 13.95052.345YesYes178
135b.b11x2 b.l12x1 17.62054.415YesYes176
136b.l18x1 g.h2x11 20.36293.61YesYes169
137b.b17x3 g.h2x11 21.80433.05YesYes159
138b.b16x6 b.b17x3 16.45063.915YesYes185
139b.b13x7 b.b16x6 10.5413.025YesYes178
140b.b12x5 b.b13x4 10.35362.21YesNo164
141b.b12x7 b.b13x4 17.09612.17YesNo194
142b.l10x4 b.l12x1 16.99864.245NoYes136
143b.b16x5 b.l14x6 11.14583.46YesNo053
144b.b19x4 b.l17x3 13.3828.9YesYes289
145b.l17x5 b.l17x6 18.21362.945NoYes269
146b.l17x5 b.l19x2 35.8065.155NoYes269
147b.l17x5 b.l19x1 17.85812.205NoYes269
148b.b22x5 b.l18x1 11.799411.255YesYes176
149b.b21x7 b.b24x6 23.925511.575YesYes158
150b.b23x6 b.b24x6 23.35486.27YesYes178
1518x47 8x49 21.18223.96NoNo086
1528x49 G.H5.22 20.99293.265NoNo064
1532x50 7x49 19.59963.37YesYes099
154G.H3.08 G.S4.04 39.30773.655YesYes299
155G.s3h2.03 b.l9x6 35.93192.815YesYes298
156b.b20x5 b.b21x7 12.18257.035NoYes075
157b.l17x3 b.l19x2 33.9813.78YesYes299
158b.b20x6 b.l17x3 20.01252.26YesYes269
159b.l11x2 b.l9x3 10.63314.41YesYes199
160b.b12x7 b.l10x4 16.24946.06YesNo193
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
1x392x572.493YesYes7722
1x397x422.163YesNo7721
2x577x425.773YesNo7721
3x32Lig3.0550NoYes5010
3x33E25.043NoYes4422
3x33E2x522.283NoYes4421
3x373x414.993YesYes6512
3x374x532.383YesNo6812
3x374x566.0753YesYes6512
3x375x4619.633YesYes6612
3x37Lig2.713YesYes6010
3x406x446.5417NoYes7922
3x406x4813.66517NoYes7821
3x415x4615.5353YesYes5622
4x565x433.333YesYes5521
4x565x4615.6453YesYes5622
4x60E219.1653YesYes5422
4x60E2x522.543YesYes5421
4x605x396.983YesYes5622
5x39E217.5753YesYes6422
E2E2102.6153YesYes4422
E2E2x523.813YesYes4421
6x51E29.4953YesYes6412
5x39E2x523.2053YesYes6421
E2x52Lig5.723YesYes4010
7x37E22.863YesYes6422
5x395x4310.913YesYes6521
5x435x4613.5553YesYes5612
5x43Lig5.153YesYes5010
6x446x485.47517YesYes9821
6x476x485.8750NoYes8821
6x487x412.59517YesNo8812
6x48Lig4.54517YesYes8010
6x517x376.2553YesYes6612
6x517x412.673YesNo6812
6x51Lig18.323YesYes6010
7x42Lig8.4353NoYes7010

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
100.00Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
85.71Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
85.71Consensussensory_onOrthosteric Ligandopsins_on
77.78Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
77.78Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
77.78Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
77.78Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
75.00Single3PQRAll-trans-Retinal3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
75.00Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
71.43Single3PXOAll-trans-Retinal3PXO-Rhodopsin-All-trans-Retinal
71.43Single5DYSAll-trans-Retinal5DYS-Rhodopsin-All-trans-Retinal
63.64Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
62.50Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
60.00Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
60.00Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
60.00Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
58.33Single9DYDAsenapine9DYD-5-HT1A-Asenapine-Go/β1/γ2
58.33Single9DYFAsenapine9DYF-5-HT1A-Asenapine-Gi1/β1/γ2
58.33Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
58.33Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
58.33Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
57.14Single4A4MAll-trans-Retinal4A4M-Rhodopsin-All-trans-Retinal-Gt(CT)
57.14Single5EN0All-trans-Retinal5EN0-Rhodopsin-All-trans-Retinal-Gt(CT)
55.56Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
55.56Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
55.56Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
55.56Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
55.56Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
55.56Consensusgi_sensoryOrthosteric Ligandgi_opsins
55.56Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
55.56Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
54.55Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
54.55Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
54.55Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
54.55Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
54.55Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
54.55Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
54.55Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
54.55Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
53.85Single5V54Methiothepin5V54-5-HT1B-Methiothepin
53.85Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
53.85Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
53.85Consensus5ht1_offOrthosteric Ligand5ht1b_off
53.85Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
53.85Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
53.85Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
53.85Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
53.85Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
50.00Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
50.00Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
50.00Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
50.00Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
50.00Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
50.00Single3D4STimolol3D4S-β2-Timolol
50.00Single3NY8ICI118-5513NY8-β2-ICI118-551
50.00Single3PBLEticlopride3PBL-D3-Eticlopride
50.00Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
50.00Single4GBRS-Carazolol4GBR-β2-S-Carazolol
50.00Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
50.00Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
50.00Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
50.00Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
50.00Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
50.00Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
50.00Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
50.00Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
50.00Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
50.00Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
50.00Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
50.00Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
50.00Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
50.00Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
50.00Consensusdopamine_offOrthosteric Ligandd2_off d3_off
46.67Single8S2TIsoprenaline8S2T-β1-Isoprenaline-chim(NtGi1-Gs)/β1/γ2
46.15Single2RH1S-Carazolol2RH1-β2-S-Carazolol
46.15Single2YCWS-Carazolol2YCW-β1-S-Carazolol
46.15Single5D6LS-Carazolol5D6L-β2-S-Carazolol
46.15Single5X7DS-Carazolol5X7D-β2-S-Carazolol-Cmpd-15
46.15Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
46.15Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
46.15Single8ZMFA1L108ZMF-5-HT2C-A1L10
46.15Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
46.15Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
46.15Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
46.15Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
46.15Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
46.15Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
46.15Consensusamine_offonOrthosteric Ligandamine_off amine_on
46.15Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
46.15Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
46.15Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
46.15Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
46.15Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
46.15Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
46.15Consensustrace-amine_onOrthosteric Ligandta1_on
45.45Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
45.45Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
45.45Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
45.45Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
45.45Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
45.45Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
45.45Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
45.45Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
45.45Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
45.45Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
45.45Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
45.45Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
45.45Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
45.45Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
44.44Single2HPYAll-trans-Retinal2HPY-Rhodopsin-All-trans-Retinal
44.44Single6OY9All-trans-Retinal6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
44.44Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
44.44Single8IWM2-Phenylethylamine8IWM-TA9-2-Phenylethylamine
44.44Single8WC5Tetramethylammonium Ion8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
43.75Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
42.86Single2YDVNECA2YDV-A2A-NECA
42.86Single4U15Tiotropium4U15-M3-Tiotropium
42.86Single4UHRCGS216804UHR-A2A-CGS21680
42.86Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
42.86Single5D5AS-Carazolol5D5A-β2-S-Carazolol
42.86Single5D5BS-Carazolol5D5B-β2-S-Carazolol
42.86Single5G53NECA5G53-A2A-NECA-Gs
42.86Single6J21Aprepitant6J21-NK1-Aprepitant
42.86Single6OL9Tiotropium6OL9-M5-Tiotropium
42.86Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
42.86Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
42.86Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
42.86Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
42.86Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
42.86Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
42.86Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
42.86Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
42.86Consensustachykinin_offOrthosteric Ligandnk1_off
41.67Single2YDOAdenosine2YDO-A2A-Adenosine
41.67Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
41.67Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
41.67Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
41.67Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
41.67Single6A94Zotepine6A94-5-HT2A-Zotepine
41.67Single6KUXRS-799486KUX-α2a-RS-79948
41.67Single6PS0S-Carazolol6PS0-β2-S-Carazolol
41.67Single6PS4ICI118-5516PS4-β2-ICI118-551
41.67Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
41.67Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
41.67Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
41.67Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
41.67Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
41.67Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
41.67Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
41.67Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
41.67Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
41.67Single7UL3Famotidine7UL3-H2-Famotidine
41.67Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
41.67Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
41.67Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
41.67Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
41.67Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
41.67Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
41.67Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
41.67Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
41.67Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
41.67Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
41.67Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
41.67Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
41.67Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
41.67Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
41.67Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
41.67Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
41.67Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
41.67Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
41.67Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
41.67Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
41.67Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
41.67Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
41.67Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
41.67Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
41.67Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
41.67Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
41.67Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
41.67Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
41.67Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
41.67Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
41.67Single9LRDHistamine9LRD-H1-Histamine-Gi1/β1/γ2
41.67Consensusalpha1_onOrthosteric Ligandalpha1a_on
41.67Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
41.67Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
41.67Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
41.67Consensusopsins_offOrthosteric Ligandrhodopsin_off
41.67Consensussensory_offOrthosteric Ligandopsins_off
41.18Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
41.18Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
41.18Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
40.00Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
40.00Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
40.00Single4AMIBucindolol4AMI-β1-Bucindolol
40.00Single5CXVTiotropium5CXV-M1-Tiotropium
40.00Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
40.00Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
40.00Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
40.00Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
40.00Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
40.00Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
40.00Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
40.00Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
40.00Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
40.00Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
40.00Single8IW72-Phenylethylamine8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
40.00Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
40.00Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
40.00Single9EBIPiclidenoson9EBI-A3A-Piclidenoson-chim(NtGi1L-Gs-CtGi1)/β1/γ2
40.00Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
40.00Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
40.00Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
40.00Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
40.00Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
40.00Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
40.00Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
38.46Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
38.46Single2Y01Dobutamine2Y01-β1-Dobutamine
38.46Single2Y04Salbutamol2Y04-β1-Salbutamol
38.46Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
38.46Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
38.46Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
38.46Single4EJ4Naltrindole4EJ4-δ-Naltrindole
38.46Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
38.46Single4QKX35V4QKX-β2-35V
38.46Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
38.46Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
38.46Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
38.46Single6H7MSalbutamol6H7M-β1-Salbutamol
38.46Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
38.46Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
38.46Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
38.46Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
38.46Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
38.46Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
38.46Single7BU7BI1671077BU7-β1-BI167107
38.46Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
38.46Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
38.46Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
38.46Single7UL4Alvimopan7UL4-μ-Alvimopan
38.46Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
38.46Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
38.46Single7WC7Lisuride7WC7-5-HT2A-Lisuride
38.46Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
38.46Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
38.46Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
38.46Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
38.46Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
38.46Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
38.46Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
38.46Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
38.46Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
38.46Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
38.46Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
38.46Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
38.46Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
38.46Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
38.46Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
38.46Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
38.46Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
38.46Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
38.46Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
38.46Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
38.46Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
38.46Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
38.46Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
38.46Single8JJOAlprenolol8JJO-β2-Alprenolol
38.46Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
38.46Single8JXRLSD8JXR-D1-LSD
38.46Single8PJKST1718PJK-5-HT1A-ST171-Gi1/β1/γ1
38.46Single8T1WCVN4248T1W-GPR6-CVN424
38.46Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
38.46Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
38.46Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
38.46Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
38.46Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
38.46Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
38.46Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
38.46Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
38.46Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
38.46Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
38.46Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
38.46Single8X64Desloratadine8X64-H1-Desloratadine
38.46Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
38.46Single9AS1DMT9AS1-5-HT2A-DMT
38.46Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
38.46Single9CHXS-Carazolol9CHX-β2-S-Carazolol
38.46Single9JEAAtropine9JEA-M1-Atropine
38.46Single9KFJPubChem 1383196749KFJ-RXFP3-PubChem 138319674-Gi2/β1/γ2
38.46Single9PLNN-(5-methylnaphthalen-1-yl)pyridin-4-amine9PLN-α2a-N-(5-methylnaphthalen-1-yl)pyridin-4-amine
38.46Single9PLON-(5-methylnaphthalen-1-yl)pyridin-4-amine9PLO-α2a-N-(5-methylnaphthalen-1-yl)pyridin-4-amine-Go/β1/γ2
38.46Single9PQD(6m)-1-methyl-6-(1,2,5,6-tetrahydropyridin-3-yl)-1h-indole9PQD-α2a-(6m)-1-methyl-6-(1,2,5,6-tetrahydropyridin-3-yl)-1h-indole
38.46Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
38.46Consensus5ht5_onOrthosteric Ligand5ht5a_on
38.46Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
38.46Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
38.46Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
38.46Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
38.46Consensusalpha2_onOrthosteric Ligandalpha2b_on
38.46Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
38.46Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
38.46Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
38.46Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
38.46Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
38.46Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
38.46Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
38.46Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
38.46Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
38.46Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
38.46Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
38.46Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
38.46Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
37.50Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
37.50Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
37.50Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
37.50Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
37.50Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
37.50Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
37.50Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
37.50Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
37.50Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
37.50Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
37.50Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
37.50Single9AS02-bromo-LSD9AS0-5-HT2A-2-bromo-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
37.50Single9DYEBuspirone9DYE-5-HT1A-Buspirone-Go/β1/γ2
37.50Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
36.84Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
36.36Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
36.36Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
36.36Single6HLLCP999946HLL-NK1-CP99994
36.36Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
36.36Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
36.36Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
36.36Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
36.36Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
36.36Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
36.36Single7V68Iperoxo7V68-M4-Iperoxo-LY2119620-Gi1/β1/γ2
36.36Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
36.36Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
36.36Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
36.36Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
36.36Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
36.36Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
36.36Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
36.36Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
36.36Single9AS2DMT9AS2-5-HT2A-DMT-chim(NtGi1-Gs-CtGq)/β1/γ2
36.36Single9EPRRetinal9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
36.36Single9IXJHistamine9IXJ-H2-Histamine-Gs/β1/γ2
36.36Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
35.71Single2Y00Dobutamine2Y00-β1-Dobutamine
35.71Single2Y03Isoprenaline2Y03-β1-Isoprenaline
35.71Single5JQHS-Carazolol5JQH-β2-S-Carazolol
35.71Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
35.71Single5WIUNemonapride5WIU-D4-Nemonapride
35.71Single5WIVNemonapride5WIV-D4-Nemonapride-Na
35.71Single6HLPNetupitant6HLP-NK1-Netupitant
35.71Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
35.71Single6LUQHaloperidol6LUQ-D2-Haloperidol
35.71Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
35.71Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
35.71Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
35.71Single6PS6Timolol6PS6-β2-Timolol
35.71Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
35.71Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
35.71Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
35.71Single7SINNPS-21437SIN-CaS-NPS-2143
35.71Single7SINNPS-21437SIN-CaS-NPS-2143
35.71Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
35.71Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
35.71Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
35.71Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
35.71Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
35.71Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
35.71Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
35.71Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
35.71Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
35.71Single8XYKVUF106618XYK-CXCR3-VUF10661-Go/β1/γ2
35.71Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
35.71Single9ARYSerotonin9ARY-5-HT2A-Serotonin-chim(NtGi1-Gs-CtGq)/β1/γ2
35.71Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
35.71Single9EE8Adenosine9EE8-A2A-Adenosine-Gs/β1/γ2
35.71Single9K07DSO-5a9K07-BB3-DSO-5a-chim(NtGi2L-Gs-CtGq)/β1/γ2
35.71Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
35.71Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
35.71Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
35.71Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
35.71Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
35.71Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
35.71Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
35.71Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
35.71Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
35.71Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
35.71Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
35.29Single3NY9ICI118-5513NY9-β2-ICI118-551
35.29Single4UG2CGS216804UG2-A2A-CGS21680
35.29Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
35.29Single7SK9CCX6627SK9-ACKR3-CCX662
33.33Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
33.33Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
33.33Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
33.33Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
33.33Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
33.33Single4IARErgotamine4IAR-5-HT1B-Ergotamine
33.33Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
33.33Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
33.33Single5WS3EMPA5WS3-OX2-EMPA
33.33Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
33.33Single6B73MP11046B73-κ-MP1104
33.33Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
33.33Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
33.33Single6H7JIsoprenaline6H7J-β1-Isoprenaline
33.33Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
33.33Single6ME9Ramelteon6ME9-MT2-Ramelteon
33.33Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
33.33Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
33.33Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
33.33Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
33.33Single6TODEMPA6TOD-OX1-EMPA-Na
33.33Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
33.33Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
33.33Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
33.33Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
33.33Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
33.33Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
33.33Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
33.33Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
33.33Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
33.33Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
33.33Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
33.33Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
33.33Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
33.33Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
33.33Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
33.33Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
33.33Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
33.33Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
33.33Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
33.33Single8IWESpermidine8IWE-TA9-Spermidine
33.33Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
33.33Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
33.33Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
33.33Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
33.33Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
33.33Single8PKMBefiradol8PKM-5-HT1A-Befiradol-Gi1/β1/γ1
33.33Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
33.33Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
33.33Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
33.33Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
33.33Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
33.33Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
33.33Single8WDTphotoNECA8WDT-A2A-photoNECA
33.33Single8XVLZibotentan8XVL-ETA-Zibotentan
33.33Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
33.33Single8Y0HVUF114188Y0H-CXCR3-VUF11418
33.33Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go/β1/γ2
33.33Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ2
33.33Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
33.33Single9AS9RS130-1809AS9-5-HT2A-RS130-180
33.33Single9ASARS130-1809ASA-5-HT2A-RS130-180-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single9BJKNaloxone9BJK-μ-Naloxone-NAM
33.33Single9EEAAdenosine9EEA-A2A-Adenosine-Gs/β1/γ2
33.33Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
33.33Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
33.33Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
33.33Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
33.33Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
33.33Consensusa2_onOrthosteric Liganda2b_on
33.33Consensusa2_on_gpOrthosteric Liganda2b_on_gp
33.33Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
33.33Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
33.33Consensusalpha2_offOrthosteric Ligandalpha2c_off
33.33Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
33.33Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
33.33Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
33.33Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
33.33Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
33.33Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
33.33Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
33.33Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
33.33Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
33.33Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
33.33Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
33.33Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
33.33Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
33.33Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
33.33Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
33.33Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
33.33Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
33.33Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
33.33Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
33.33Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
31.58Single6HLOAprepitant6HLO-NK1-Aprepitant
31.58Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
31.58Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
31.25Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
31.25Single4LDEBI1671074LDE-β2-BI167107
31.25Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
31.25Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
31.25Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
31.25Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
31.25Single6ZG4HTL00099366ZG4-M1-HTL0009936
31.25Single7K15MKD0467K15-BLT1-MKD046-Na
31.25Single7YITNalfurafine7YIT-κ-Nalfurafine
31.25Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
31.25Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
31.25Single8JJ8Formoterol8JJ8-β2-Formoterol
31.25Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
31.25Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
31.25Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
31.25Single8XYIVUF106618XYI-CXCR3-VUF10661
31.25Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
31.25Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
31.25Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
31.25Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
31.25Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
31.25Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
31.25Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
31.25Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
31.25Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
30.77Single3RZECidoxepin3RZE-H1-Cidoxepin
30.77Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
30.77Single4ZJCSB-6740424ZJC-OX1-SB-674042
30.77Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
30.77Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
30.77Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
30.77Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
30.77Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
30.77Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
30.77Single6PS5S-Propranolol6PS5-β2-S-Propranolol
30.77Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
30.77Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
30.77Single6TPGEMPA6TPG-OX2-EMPA
30.77Single6TPNHTL66416TPN-OX2-HTL6641
30.77Single6V9SGTPL114036V9S-OX1-GTPL11403
30.77Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
30.77Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
30.77Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
30.77Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
30.77Single7T94Acetylcholine7T94-M2-Acetylcholine-LY2119620-chim(NtGi1-Go)/β1/γ2
30.77Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
30.77Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
30.77Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.77Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.77Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
30.77Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
30.77Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
30.77Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
30.77Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
30.77Single8RLNLUF58348RLN-A2A-LUF5834
30.77Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.77Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.77Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
30.77Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
30.77Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
30.77Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
30.77Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
30.77Single9AS3LSD9AS3-5-HT2A-LSD
30.77Single9AS4LSD9AS4-5-HT2A-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
30.77Single9AS5Mescaline9AS5-5-HT2A-Mescaline
30.77Single9AS6Mescaline9AS6-5-HT2A-Mescaline-chim(NtGi1-Gs-CtGq)/β1/γ2
30.77Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
30.77Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
30.77Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
30.77Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
30.77Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
30.77Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
30.77Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
30.43Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
30.00Single5WF5UK-4320975WF5-A2A-UK-432097
30.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
30.00Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
30.00Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
30.00Single9EE9Adenosine9EE9-A2A-Adenosine-Gs/β1/γ2
30.00Consensusgs_histamineOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
30.00Consensush2_onOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
29.41Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
29.41Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
29.41Single5X93K-87945X93-ETB-K-8794
29.41Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
29.41Single6H7LDobutamine6H7L-β1-Dobutamine
29.41Single6IBLArformoterol6IBL-β1-Arformoterol
29.41Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
29.41Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
29.41Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
29.41Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
29.41Single7UM4AS26747237UM4-5-HT5A-AS2674723
29.41Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
29.41Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
29.41Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
29.41Single8T3OTUG-8918T3O-FFA4-TUG-891-chim(NtGi2L-Gs-CtGq)/β1/γ2
29.41Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
29.41Single9CGJC6-Quino9CGJ-δ-C6-Quino-Gi1/β1/γ2
29.41Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
29.41Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
29.41Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
29.41Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
29.41Consensusendothelin_offOrthosteric Ligandetb_off
29.41Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
29.41Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
28.57Single2Y02Carmoterol2Y02-β1-Carmoterol
28.57Single4MQSIperoxo4MQS-M2-Iperoxo
28.57Single4U14Tiotropium4U14-M3-Tiotropium
28.57Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
28.57Single5TGZAM65385TGZ-CB1-AM6538
28.57Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
28.57Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
28.57Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
28.57Single6PS1Timolol6PS1-β2-Timolol
28.57Single6TOTLemborexant6TOT-OX1-Lemborexant
28.57Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
28.57Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
28.57Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
28.57Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
28.57Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
28.57Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
28.57Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
28.57Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
28.57Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
28.57Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
28.57Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
28.57Single8CU6LJ-45178CU6-A2A-LJ-4517
28.57Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
28.57Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
28.57Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
28.57Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
28.57Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
28.57Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
28.57Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
28.57Single9JGKBalovaptan9JGK-5-HT2B-Balovaptan
28.57Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
28.57Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
28.57Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
28.57Consensusblt_onOrthosteric Ligandblt1_on
28.57Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
28.57Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
28.57Consensusleukotriene_onOrthosteric Ligandblt_on
28.57Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
27.78Single5WF6UK-4320975WF6-A2A-UK-432097
27.78Single6PT3DPI-2876PT3-δ-DPI-287
27.78Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
27.78Single7XN9L-054,5227XN9-SST2-L-054,522
27.78Single8X5YAstemizole8X5Y-H1-Astemizole
27.78Single9CGKC5-Quino9CGK-δ-C5-Quino-Gi1/β1/γ2
27.78Single9MD1Buspirone9MD1-5-HT1A-Buspirone-Gz/β1/γ2
27.78Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
27.78Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
27.78Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
27.78Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
27.78Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
27.78Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
27.27Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
27.27Single3UZAGTPL92363UZA-A2A-GTPL9236
27.27Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
27.27Single6ME5Agomelatine6ME5-MT1-Agomelatine
27.27Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
27.27Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.27Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
27.27Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
27.27Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
27.27Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
27.27Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
27.27Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
27.27Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
27.27Single9LRCHistamine9LRC-H4-Histamine
27.27Single9LREHistamine9LRE-H4-Histamine-Gi1/β1/γ2
27.27Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
27.27Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
26.67Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
26.67Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
26.67Single5C1MBU725C1M-μ-BU72
26.67Single5CGCHTL142425CGC-mGlu5-HTL14242
26.67Single5N2RPSB-365N2R-A2A-PSB-36-Na
26.67Single5N2SPSB365N2S-A1-PSB36
26.67Single5TVNLSD5TVN-5-HT2B-LSD
26.67Single5WQCEMPA5WQC-OX2-EMPA
26.67Single5XPRBosentan5XPR-ETB-Bosentan
26.67Single6E67BI1671076E67-β2-BI167107-Gs(CT)
26.67Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
26.67Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
26.67Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
26.67Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
26.67Single6TP6Filorexant6TP6-OX1-Filorexant
26.67Single7C61Ergotamine7C61-5-HT1B-Ergotamine
26.67Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
26.67Single7LD3Adenosine7LD3-A1-Adenosine-MIPS521-Gi2/β1/γ2
26.67Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
26.67Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
26.67Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
26.67Single7W41PD1762527W41-BB2-PD176252
26.67Single7WC6LSD7WC6-5-HT2A-LSD
26.67Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
26.67Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
26.67Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
26.67Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
26.67Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
26.67Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
26.67Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
26.67Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
26.67Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
26.67Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
26.67Single9ARZ2-bromo-LSD9ARZ-5-HT2A-2-bromo-LSD
26.67Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
26.67Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
26.67Single9F33FOB02-04A9F33-D3-FOB02-04A-Go/β1/γ2
26.67Single9F34FOB02-04A9F34-D3-FOB02-04A-Go/β1/γ2
26.67Single9HAPTolvaptan9HAP-V2-Tolvaptan
26.67Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
26.67Consensusa3_on_gpOrthosteric Liganda3a_on_gp
26.67Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
26.67Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
26.67Consensusadenosine_offOrthosteric Liganda1_off a2_off
26.67Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
26.67Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
26.67Consensusblt_offOrthosteric Ligandblt1_off
26.67Consensusbombesin_offOrthosteric Ligandbb2_off
26.67Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
26.67Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
26.67Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
26.67Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
26.67Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
26.67Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
26.32Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
26.32Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
26.32Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
26.32Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
26.32Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
26.32Single8ZBJSomatostatin-148ZBJ-SST5-Somatostatin-14-Gi1/β1/γ2
26.32Single9BUYLM1899BUY-β2-LM189-Gi1/β1/γ2
26.32Single9M4TSilodosin9M4T-Alpha1A-Silodosin
26.32Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
26.32Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
25.00Single3P0GBI1671073P0G-β2-BI167107
25.00Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
25.00Single3QAKUK-4320973QAK-A2A-UK-432097
25.00Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
25.00Single4DJHJDTic4DJH-κ-JDTic
25.00Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
25.00Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
25.00Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
25.00Single6J20Aprepitant6J20-NK1-Aprepitant
25.00Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
25.00Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
25.00Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
25.00Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
25.00Single6TP4ACT-4622066TP4-OX1-ACT-462206
25.00Single6TQ7SB-3348676TQ7-OX1-SB-334867
25.00Single6WGTLSD6WGT-5-HT2A-LSD
25.00Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
25.00Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
25.00Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
25.00Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
25.00Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
25.00Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
25.00Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
25.00Single7SRQLSD7SRQ-5-HT2B-LSD
25.00Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
25.00Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
25.00Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
25.00Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
25.00Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
25.00Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
25.00Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
25.00Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
25.00Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
25.00Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
25.00Single8E0GBU728E0G-μ-BU72
25.00Single8EA0Iperoxo8EA0-M3-Iperoxo
25.00Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
25.00Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
25.00Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
25.00Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
25.00Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
25.00Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
25.00Single8K5BNiacin8K5B-HCA2-Niacin
25.00Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
25.00Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
25.00Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
25.00Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
25.00Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
25.00Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
25.00Single8YN2Histamine8YN2-H1-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
25.00Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
25.00Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
25.00Single8YN7Immethridine8YN7-H3-Immethridine-Go/β1/γ2
25.00Single8YNTSNAP-948478YNT-MCH1-SNAP-94847
25.00Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
25.00Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
25.00Single9I54A1IZV9I54-D1-A1IZV-Gs/β1/γ2
25.00Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
25.00Single9IK8SST analogue9IK8-SST1-SST analogue-Gi1/β1/γ2
25.00Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
25.00Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
25.00Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
25.00Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
25.00Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
25.00Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
25.00Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
25.00Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
25.00Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
25.00Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
25.00Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
25.00Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
23.81Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
23.81Single6PT2KGCHM076PT2-δ-KGCHM07
23.81Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
23.81Consensusangiotensin_onOrthosteric Ligandat1_on
23.81Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
23.81Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
23.81Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
23.81Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
23.81Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
23.53Single4RWADIPP-NH24RWA-δ-DIPP-NH2
23.53Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
23.53Single6A93Risperidone6A93-5-HT2A-Risperidone
23.53Single6CM4Risperidone6CM4-D2-Risperidone
23.53Single6MXTSalmeterol6MXT-β2-Salmeterol
23.53Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
23.53Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
23.53Single7DFPSpiperone7DFP-D2-Spiperone
23.53Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
23.53Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
23.53Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
23.53Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
23.53Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
23.53Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
23.53Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
23.53Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
23.53Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
23.53Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
23.53Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
23.53Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
23.53Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
23.53Single8JD3JNJ-404118138JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
23.53Single8JJLOlodaterol8JJL-β2-Olodaterol
23.53Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
23.53Single9GL2Befiradol9GL2-5-HT1A-Befiradol-Gs/β1/γ2
23.53Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
23.53Single9M4QDoxazosin9M4Q-Alpha1A-Doxazosin
23.53Consensusalpha1_offOrthosteric Ligandalpha1a_off
23.53Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
23.53Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
23.53Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
23.53Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
23.53Consensuslpa_offOrthosteric Ligandlpa1_off
23.53Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
23.53Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
23.53Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
23.53Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
23.53Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
23.53Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
23.08Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
23.08Single4S0VSuvorexant4S0V-OX2-Suvorexant
23.08Single6AKXA4R6AKX-CCR5-A4R
23.08Single6AKYMaraviroc6AKY-CCR5-Maraviroc
23.08Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
23.08Single6ME2Ramelteon6ME2-MT1-Ramelteon
23.08Single6TPJSuvorexant6TPJ-OX2-Suvorexant
23.08Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
23.08Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
23.08Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
23.08Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
23.08Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
23.08Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
23.08Single7XRRLemborexant7XRR-OX2-Lemborexant
23.08Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
23.08Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
23.08Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
23.08Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
23.08Single8GNGIstradefylline8GNG-A2A-Istradefylline
23.08Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
23.08Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
23.08Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
23.08Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
23.08Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
23.08Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
23.08Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
23.08Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
23.08Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
23.08Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
23.08Single8YYWAlpha-ketoglutarate8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
23.08Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
23.08Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
23.08Single9EBHAdenosine9EBH-A3A-Adenosine-Gi1/β1/γ2
23.08Single9H2XA1IR19H2X-A2A-A1IR1-Na
23.08Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
23.08Single9LRBHistamine9LRB-H1-Histamine-Gs/β1/γ2
23.08Consensusangiotensin_offOrthosteric Ligandat1_off
23.08Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
23.08Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
23.08Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
23.08Consensusorexin_offOrthosteric Ligandox2_off ox1_off
23.08Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
23.08Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
23.08Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
22.73Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
22.73Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
22.73Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
22.73Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
22.73Single8ZBISomatostatin-148ZBI-SST3-Somatostatin-14-Gi1/β1/γ2
22.73Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
22.73Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
22.73Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
22.73Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
22.73Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
22.73Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
22.73Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
22.22Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
22.22Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
22.22Single5CGDHTL142425CGD-mGlu5-HTL14242
22.22Single5MZPCaffeine5MZP-A2A-Caffeine-Na
22.22Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
22.22Single7EZCUKA7EZC-A2A-UKA
22.22Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
22.22Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
22.22Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.22Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
22.22Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
22.22Single8GEJConstrained Epinephrine8GEJ-β2-Constrained Epinephrine-Gs/β1/γ2
22.22Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
22.22Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
22.22Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
22.22Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
22.22Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Single8XVJMacitentan8XVJ-ETA-Macitentan
22.22Single8ZWGJR14a8ZWG-C3aB-JR14a-Gi1/β1/γ2
22.22Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
22.22Consensuschemerin_onOrthosteric Ligandcml1_on
22.22Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
22.22Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
22.22Consensusprostanoid_offOrthosteric Ligandep_off dp_off
21.74Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
21.74Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
21.74Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
21.74Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
21.74Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
21.43Single4MBSMaraviroc4MBS-CCR5-Maraviroc
21.43Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
21.43Single5IU7Q274563465IU7-A2A-Q27456346-Na
21.43Single5JTBZM-2413855JTB-A2A-ZM-241385
21.43Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
21.43Single5UVIZM-2413855UVI-A2A-ZM-241385
21.43Single6AQFZM-2413856AQF-A2A-ZM-241385
21.43Single6FFIMMPEP6FFI-mGlu5-MMPEP
21.43Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
21.43Single6IQLL7458706IQL-D4-L745870
21.43Single6MH8ZM-2413856MH8-A2A-ZM-241385
21.43Single6TP3Nemorexant6TP3-OX1-Nemorexant
21.43Single6TPKRetosiban6TPK-OT-Retosiban
21.43Single6VI4JDTic6VI4-κ-JDTic
21.43Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
21.43Single6ZG9GSK10347026ZG9-M1-GSK1034702
21.43Single7AROLUF58337ARO-A2A-LUF5833-Na
21.43Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
21.43Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
21.43Single7T32ZM-2413857T32-A2A-ZM-241385
21.43Single7VODCariprazine7VOD-5-HT2A-Cariprazine
21.43Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
21.43Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
21.43Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
21.43Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
21.43Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
21.43Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
21.43Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
21.43Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
21.43Single8K5CAcipimox8K5C-HCA2-Acipimox
21.43Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
21.43Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
21.43Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
21.43Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
21.43Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.43Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
21.43Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
21.43Single9ARXSerotonin9ARX-5-HT2A-Serotonin
21.43Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
21.43Single9JH3CMF-0199JH3-Apelin-CMF-019-Gi1/β1/γ2
21.43Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
21.43Consensusa2_offOrthosteric Liganda2a_off
21.43Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
21.43Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
21.43Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
21.43Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
21.43Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
21.43Consensushca_onOrthosteric Ligandhca2_on
21.43Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
21.43Consensusvasop-oxy_offOrthosteric Ligandot_off
21.05Single5ZTYAM102575ZTY-CB2-AM10257
21.05Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
21.05Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
21.05Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
21.05Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
21.05Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
21.05Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
21.05Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
21.05Single8Y72Peptide8Y72-μ-Peptide-BMS-986122-Gi1/β1/γ2
21.05Single9IPVJR14a9IPV-C3aB-JR14a-Gi1/β1/γ2
21.05Single9IPYJR14a9IPY-C3aB-JR14a
21.05Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
21.05Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
20.83Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
20.83Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single3EMLZM-2413853EML-A2A-ZM-241385
20.00Single4DAJTiotropium4DAJ-M3-Tiotropium
20.00Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
20.00Single4YAYZD-71554YAY-AT1-ZD-7155
20.00Single5DSGTiotropium5DSG-M4-Tiotropium
20.00Single5IU8Q274563475IU8-A2A-Q27456347-Na
20.00Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
20.00Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
20.00Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
20.00Single5UENDU1725UEN-A1-DU172
20.00Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
20.00Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
20.00Single6D27CAY104716D27-DP2-CAY10471
20.00Single6DRXLisuride6DRX-5-HT2B-Lisuride
20.00Single6FFHFenobam6FFH-mGlu5-Fenobam
20.00Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
20.00Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
20.00Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
20.00Single6IIVDaltroban6IIV-TXA2-Daltroban
20.00Single6S0LZM-2413856S0L-A2A-ZM-241385
20.00Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
20.00Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
20.00Single7F83PF-051904577F83-Ghrelin-PF-05190457
20.00Single7F8XNN90567F8X-CCKA-NN9056
20.00Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
20.00Single7PYRPSB-21157PYR-A2A-PSB-2115
20.00Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
20.00Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
20.00Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
20.00Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
20.00Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
20.00Single7WC4Serotonin7WC4-5-HT2A-Serotonin
20.00Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
20.00Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
20.00Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
20.00Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
20.00Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
20.00Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
20.00Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
20.00Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
20.00Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
20.00Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
20.00Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
20.00Single8K5DGSK2560738K5D-HCA2-GSK256073
20.00Single8PWNTheophylline8PWN-A2A-Theophylline
20.00Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
20.00Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
20.00Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
20.00Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
20.00Single8X63Mepyramine8X63-H1-Mepyramine
20.00Single8YN8Proxyfan8YN8-H3-Proxyfan-Go/β1/γ2
20.00Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
20.00Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
20.00Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
20.00Single9H37A1IR09H37-A2A-A1IR0-Na
20.00Single9IYAONO-97105319IYA-GPR55-ONO-9710531
20.00Single9IZCMK19039IZC-HCA2-MK1903-Gi1/β1/γ2
20.00Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
20.00Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
20.00Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
20.00Consensusa3_onOrthosteric Liganda3a_on
20.00Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
20.00Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
20.00Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
20.00Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
20.00Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
20.00Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
20.00Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
20.00Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
20.00Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
20.00Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
20.00Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
20.00Consensushca_on_gpOrthosteric Ligandhca2_on_gp
20.00Consensushistamine_offOrthosteric Ligandh1_off
20.00Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
19.23Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
19.23Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
19.23Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
19.23Consensusbradykinin_onOrthosteric Ligandbk2_on
19.23Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
19.23Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
19.05Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
19.05Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
19.05Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
19.05Single9E82SDF-1-beta9E82-ACKR3-SDF-1-β-Arrestin2
19.05Single9KFIRelaxin-39KFI-RXFP3-Relaxin-3-Gi2/β1/γ2
18.75Single4NTJAZD12834NTJ-P2Y12-AZD1283
18.75Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
18.75Single5IUAQ274563485IUA-A2A-Q27456348-Na
18.75Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
18.75Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
18.75Single6D26Fevipiprant6D26-DP2-Fevipiprant
18.75Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
18.75Single6S0QZM-2413856S0Q-A2A-ZM-241385
18.75Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
18.75Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
18.75Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
18.75Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
18.75Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
18.75Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
18.75Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
18.75Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
18.75Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
18.75Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
18.75Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
18.75Single8GNEKW-63568GNE-A2A-KW-6356-Na
18.75Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
18.75Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
18.75Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
18.75Single8JXSPF-61428JXS-D1-PF-6142
18.75Single8QOTNanobody-E8QOT-μ-Nanobody-E
18.75Single8S4DCMF-0198S4D-Apelin-CMF-019
18.75Single8TF5Oleic acid8TF5-GPR6-Oleic acid
18.75Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
18.75Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
18.75Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
18.75Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
18.75Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
18.75Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
18.75Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
18.75Single9CIBFCH-22964139CIB-HCA2-FCH-2296413
18.75Single9EHSLUF76029EHS-A3A-LUF7602
18.75Single9I52A1IZU9I52-D1-A1IZU-Gs/β1/γ2
18.75Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
18.75Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
18.75Consensusdp_offOrthosteric Liganddp2_off
18.75Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
18.75Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
18.75Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
18.75Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
18.52Single5GLHEndothelin-15GLH-ETB-Endothelin-1
18.52Single6IGKEndothelin-36IGK-ETB-Endothelin-3
18.52Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
18.52Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
18.52Consensusbombesin_onOrthosteric Ligandbb2_on
18.52Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
18.52Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
18.18Single3RFMCaffeine3RFM-A2A-Caffeine
18.18Single6TQ9SB-4081246TQ9-OX1-SB-408124
18.18Single8A2OTheophylline8A2O-A2A-Theophylline-Na
18.18Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
18.18Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
18.18Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
18.18Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
18.18Single8Y02Retinal8Y02-OPN1SW-Retinal-Gi1/β1/γ2
18.18Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
18.18Single9CHUNoradrenaline9CHU-β2-Noradrenaline
18.18Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
18.18Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
18.18Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
17.65Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
17.65Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
17.65Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
17.65Single6E59L-7607356E59-NK1-L-760735
17.65Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
17.65Single7B6WCyclazosin7B6W-α1b-Cyclazosin
17.65Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
17.65Single7PX4PSB-21137PX4-A2A-PSB-2113
17.65Single7TUYGSK682753A7TUY-GPR183-GSK682753A
17.65Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
17.65Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
17.65Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
17.65Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
17.65Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
17.65Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
17.65Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
17.65Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
17.65Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
17.65Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
17.65Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
17.65Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
17.65Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
17.65Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
17.65Single8ZWFJR14a8ZWF-C3aB-JR14a
17.65Single9IK9SST analogue9IK9-SST1-SST analogue-Gi1/β1/γ2
17.65Single9JMCDS-3801b9JMC-Motilin-DS-3801b-chim(Gs-CtGq)/β1/γ2
17.65Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
17.65Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
17.65Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
17.65Consensusrelaxin_onOrthosteric Ligandrxfp4_on
17.65Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
17.39Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
17.39Single6JODAngiotensin II6JOD-AT2-Angiotensin II
17.39Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
17.39Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
17.39Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
17.39Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
17.39Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
17.39Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
17.39Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
17.39Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
17.39Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
17.39Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
17.39Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
17.39Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
17.39Consensusvasop-oxy_onOrthosteric Ligandv2_on
17.39Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
17.24Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
16.67Single5TZYMK8666; AP85TZY-FFA1-MK8666; AP8
16.67Single5X33BIIL2605X33-BLT1-BIIL260
16.67Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
16.67Single6IIURamatroban6IIU-TXA2-Ramatroban
16.67Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
16.67Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
16.67Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
16.67Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
16.67Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
16.67Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
16.67Single7WC5Psilocin7WC5-5-HT2A-Psilocin
16.67Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
16.67Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
16.67Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
16.67Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.67Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
16.67Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
16.67Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
16.67Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
16.67Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
16.67Single8JWY2-1188JWY-A2A-2-118
16.67Single8JWZAB9288JWZ-A2A-AB928-Na
16.67Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
16.67Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
16.67Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
16.67Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
16.67Single8XJNCloprosetnol8XJN-TXA2-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single9GGGI-BOP9GGG-TXA2-I-BOP-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
16.67Single9JHJC18:0 Ceramide9JHJ-FPR2-ALX-C18:0 Ceramide-Gi1/β1/γ2
16.67Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
16.67Consensus5ht2_onOrthosteric Ligand5ht2b_on
16.67Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
16.67Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
16.67Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
16.67Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
16.67Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
16.67Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
16.67Consensuslpl_offOrthosteric Ligands1p_off lpa_off
16.67Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
16.67Consensusorexin_onOrthosteric Ligandox2_on
16.00Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
16.00Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
16.00Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
16.00Single9BLWCagrilintide backbone (non-acylated)9BLW-CT (AMY1)-Cagrilintide backbone (non-acylated)-Gs/β1/γ2; RAMP1
16.00Single9BP3Cagrilintide9BP3-CT (AMY1)-Cagrilintide-Gs/β1/γ2; RAMP1
16.00Single9KFKRelaxin-39KFK-RXFP4-Relaxin-3-Gi2/β1/γ2
16.00Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
16.00Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
16.00Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
16.00Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
15.79Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
15.79Single6K1QIRL25006K1Q-ETB-IRL2500
15.79Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
15.79Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
15.79Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
15.79Single8XJOU466198XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
15.79Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
15.79Single9C0KExendin-49C0K-GLP-1-Exendin-4-Gs/β1/γ2
15.79Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
15.79Single9GG5U466199GG5-TXA2-U46619-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.79Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
15.79Consensusfp-alpha_onOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
15.79Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
15.79Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
15.79Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
15.79Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
15.79Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
15.79Consensustp_onOrthosteric Ligand8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
15.79Consensustp_on_gpOrthosteric Ligand8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Single3OE9IT1t3OE9-CXCR4-IT1t
15.38Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
15.38Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
15.38Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
15.38Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
15.38Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.38Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
15.38Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
15.38Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
15.38Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
15.38Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
15.38Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
15.38Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
15.38Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.38Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
15.38Single8YKDDehydroepiandrosterone8YKD-ADGRG2-Dehydroepiandrosterone-chim(NtGi1-Gs)/β1/γ2
15.38Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
15.38Single9AS7Psilocin9AS7-5-HT2A-Psilocin
15.38Single9B9Y7DY9B9Y-CB1-7DY
15.38Single9BUCCagrilintide9BUC-CT-Cagrilintide-Gs/β1/γ2
15.38Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
15.38Single9IZDCHBA9IZD-HCA1-CHBA-Gi1/β1/γ2
15.38Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
15.38Single9KDFRES-701-39KDF-ETB-RES-701-3
15.38Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
15.38Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
15.00Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
15.00Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
15.00Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
15.00Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
15.00Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
15.00Single9IZASCH9002719IZA-HCA2-SCH900271-Gi1/β1/γ2
15.00Single9JF4PD1683689JF4-BB1-PD168368
15.00Single9M0RNeuropeptide VF9M0R-NPFF1-Neuropeptide VF-Gi1/β1/γ2
15.00Single9V2NMacimorelin9V2N-Ghrelin-Macimorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
15.00Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
15.00Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
14.81Single6IGLIRL16206IGL-ETB-IRL1620
14.81Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
14.81Single8IY6Endothelin-18IY6-ETB-Endothelin-1
14.81Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
14.81Consensusendothelin_onOrthosteric Ligandetb_on eta_on
14.81Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
14.29Single3PWHZM-2413853PWH-A2A-ZM-241385
14.29Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
14.29Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
14.29Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
14.29Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
14.29Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
14.29Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
14.29Single6DS0Ly2660976DS0-5-HT2B-Ly266097
14.29Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
14.29Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
14.29Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
14.29Single7BR3Elagolix7BR3-GnRH1-Elagolix
14.29Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
14.29Single7F8ULintitript7F8U-CCKA-Lintitript
14.29Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
14.29Single7QA8Peptide7QA8-STE2-Peptide
14.29Single7QA8Peptide7QA8-STE2-Peptide
14.29Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
14.29Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
14.29Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
14.29Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
14.29Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
14.29Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
14.29Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
14.29Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
14.29Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
14.29Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
14.29Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
14.29Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
14.29Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
14.29Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
14.29Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
14.29Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
14.29Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
14.29Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
14.29Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
14.29Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
14.29Single9HB3Mambaquaretin-19HB3-V2-Mambaquaretin-1
14.29Single9K6LSA09K6L-TAS2R16-SA0-Gi2/β1/γ2
14.29Single9KPESA09KPE-TAS2R16-SA0-Gi1/β1/γ2
14.29Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
14.29Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29Consensuscrf1_onOrthosteric Ligand6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF1-Corticoliberin-Gs/β1/γ2
14.29Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
14.29Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
14.29Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
14.29Consensuslpl_onOrthosteric Ligands1p_on lpa_on
14.29Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
14.29Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
14.29Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
13.79Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
13.79Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
13.79Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
13.79Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
13.64Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
13.64Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
13.64Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
13.64Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
13.64Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
13.64Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
13.64Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
13.64Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
13.64Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
13.64Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
13.64Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
13.64Single9IQVMuscarinic toxin 39IQV-Alpha1A-Muscarinic toxin 3
13.64Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
13.64Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
13.64Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
13.33Single3REYXAC3REY-A2A-XAC
13.33Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
13.33Single5IUBQ274563445IUB-A2A-Q27456344-Na
13.33Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
13.33Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
13.33Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
13.33Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
13.33Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
13.33Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
13.33Single7F61PF-036547467F61-H3-PF-03654746
13.33Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
13.33Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
13.33Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
13.33Single8IHKAcifran8IHK-HCA3-Acifran
13.33Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.33Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
13.33Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
13.33Single8Y6YGLPG09748Y6Y-FFA2-GLPG0974
13.33Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
13.33Single8ZPMAMD0708ZPM-CXCR4-AMD070
13.33Single8ZPNAMD31008ZPN-CXCR4-AMD3100
13.33Single9BA0A1AKN9BA0-CB1-A1AKN
13.33Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Gi1/β1/γ2
13.33Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
13.33Consensuscrf1_on_gpOrthosteric Ligand6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF1-Corticoliberin-Gs/β1/γ2
13.33Consensuscrf_on_gpOrthosteric Ligandcrf2_on_gp crf1_on_gp
13.33Consensusgrh_offOrthosteric Ligandgnrh1_off
13.33Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
13.33Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
13.33Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
13.33Consensuspth1_on_gpOrthosteric Ligand6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
13.04Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.04Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
13.04Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
13.04Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
13.04Single8W8YGamma-MSH8W8Y-MC3-γ-MSH-Ca-Gs/β1/γ2
13.04Single9U4WGonadoliberin-19U4W-GnRH1-Gonadoliberin-1-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.04Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
13.04Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
12.90Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
12.90Consensusclass-a_class-b1_cons_on_gpOrthosteric Ligandclass-a_on_gp class-b1_on_gp
12.90Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
12.50Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
12.50Single5DHGC-355DHG-NOP-C-35
12.50Single5DHHSB-6121115DHH-NOP-SB-612111
12.50Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
12.50Single5UIGCmpd-15UIG-A2A-Cmpd-1
12.50Single6GPSMK08126GPS-CCR2-MK0812
12.50Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
12.50Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
12.50Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
12.50Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
12.50Single6XBM5LWE6XBM-SMO-5LWE-Gi1/β1/γ2
12.50Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
12.50Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
12.50Single7V3ZCP559407V3Z-CB1-CP55940
12.50Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
12.50Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
12.50Single7YXAONO-54306087YXA-S1P5-ONO-5430608
12.50Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
12.50Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
12.50Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
12.50Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
12.50Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
12.50Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
12.50Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
12.50Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
12.50Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
12.50Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
12.50Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
12.50Single9BLCCagrilintide backbone (non-acylated)9BLC-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
12.50Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
12.50Single9BUDCagrilintide9BUD-CT-Cagrilintide-Gs/β1/γ2
12.50Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
12.50Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
12.50Consensuscck_offOrthosteric Ligandccka_off
12.50Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
12.50Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
12.50Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
12.50Consensusgluc_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
12.50Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
12.50Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
12.50Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
12.50Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
12.12Consensusgluc_on_gpOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
12.00Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
12.00Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
12.00Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
12.00Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
12.00Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
12.00Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
12.00Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
12.00Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
12.00Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
12.00Single8ZRTET-18ZRT-ETB-ET-1
12.00Single9JFYhNPSF9JFY-NPFF2-hNPSF-Gi1/β1/γ2
12.00Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
12.00Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
12.00Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
12.00Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
12.00Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
12.00Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
12.00Consensusvpac1_onOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
11.76Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
11.76Single5T1ABMS-6815T1A-CCR2-BMS-681-PubChem 12093170
11.76Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
11.76Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
11.76Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
11.76Single6GPXMK08126GPX-CCR2-MK0812
11.76Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
11.76Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
11.76Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
11.76Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
11.76Single7C4SS1P7C4S-S1P3-S1P
11.76Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
11.76Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
11.76Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
11.76Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
11.76Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.76Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
11.76Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
11.76Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
11.76Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
11.76Single8WGBVU01550418WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
11.76Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
11.76Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
11.76Single8ZVZBW245C8ZVZ-DP1-BW245C-Gs/β1/γ2
11.76Single9B9ZA1AKO9B9Z-CB1-A1AKO
11.76Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
11.76Single9GE2ML1849GE2-GPR55-ML184-chim(NtGi1-G13)/β1/γ2
11.76Single9HC04YI9HC0-mGlu5-4YI
11.76Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
11.76Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
11.76Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
11.76Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
11.76Consensusep_offOrthosteric Ligandep4_off
11.76Consensuspth2_on_gpOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
11.76Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
11.54Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
11.54Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
11.54Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
11.54Single9BLBCagrilintide backbone (non-acylated)9BLB-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
11.54Single9BUBCagrilintide9BUB-CT-Cagrilintide-Gs/β1/γ2
11.54Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
11.54Consensuscrf2_on_gpOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
11.54Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
11.54Consensuspac1_onOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
11.54Consensuspac1_on_gpOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
11.54Consensussecretin_onOrthosteric Ligand7D3S-Secretin-Secretin-Gs/β1/γ2
11.54Consensusvpac1_on_gpOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
11.43Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
11.11Single5TZRMK86665TZR-FFA1-MK8666
11.11Single5XR8AM8415XR8-CB1-AM841
11.11Single5XRAAM115425XRA-CB1-AM11542
11.11Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
11.11Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
11.11Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
11.11Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
11.11Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
11.11Single7FEECP559407FEE-CB1-CP55940-ZCZ011
11.11Single7P2L4YI7P2L-mGlu5-4YI
11.11Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
11.11Single7T9NDPPC7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
11.11Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
11.11Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
11.11Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
11.11Single8GDBPGE28GDB-EP4-PGE2-Gs/β1/γ2
11.11Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
11.11Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
11.11Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single8JD5JNJ-40411813; ADX881788JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
11.11Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
11.11Single8W8WAlpha-MSH8W8W-MC3-α-MSH-Ca-Gs/β1/γ2
11.11Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
11.11Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
11.11Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
11.11Single8ZW0PGD28ZW0-DP1-PGD2-Gs/β1/γ2
11.11Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
11.11Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
11.11Single9CLWTUG-13759CLW-FFA2-TUG-1375-4-CMTB-chim(NtGi1L-Gs-CtGq)/β1/γ2
11.11Single9EGOYVF9EGO-CB1-YVF-Gi1/β1/γ2
11.11Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
11.11Single9UY3Anamorelin9UY3-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
11.11Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
11.11Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
11.11Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
11.11Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
11.11Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
11.11Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
11.11Consensusglp2_on_gpOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
11.11Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
11.11Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
11.11Consensussecretin_on_gpOrthosteric Ligand7D3S-Secretin-Secretin-Gs/β1/γ2
10.71Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
10.71Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
10.71Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
10.71Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
10.71Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
10.71Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
10.71Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
10.71Single9BTWCagrilintide9BTW-CT (AMY3)-Cagrilintide-Gs/β1/γ2; RAMP3
10.71Consensusctlike_on_gpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
10.71Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
10.71Consensuspth1_onOrthosteric Ligand6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
10.71Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
10.71Consensusvpac2_on_gpOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
10.53Single4N4WSANT-14N4W-SMO-SANT-1
10.53Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
10.53Single6KQICP559406KQI-CB1-CP55940-Org27569
10.53Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
10.53Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
10.53Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
10.53Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
10.53Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
10.53Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
10.53Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
10.53Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
10.53Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
10.53Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
10.53Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
10.53Single8Y6WTUG-13758Y6W-FFA2-TUG-1375-4-CMTB-Gi1/β1/γ2
10.53Single9AU0BW245C9AU0-DP1-BW245C-Gs/β1/γ2
10.53Single9BJKNAM9BJK-μ-Naloxone-NAM
10.53Single9CM3TUG-13759CM3-FFA2-TUG-1375-Compound 187-chim(NtGi1L-Gs-CtGq)/β1/γ2
10.53Single9DGIZ85267113509DGI-CB1-Z8526711350
10.53Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
10.53Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
10.53Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
10.53Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
10.53Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
10.53Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
10.53Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
10.53Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
10.53Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
10.53Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
10.34Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
10.34Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
10.34Consensusclass-a_class-b1_cons_onOrthosteric Ligandclass-a_on class-b1_on
10.34Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
10.34Consensusgip_onOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
10.34Consensusgip_on_gpOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
10.34Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
10.34Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
10.00Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
10.00Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
10.00Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
10.00Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
10.00Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
10.00Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
10.00Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
10.00Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
10.00Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
10.00Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
10.00Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
10.00Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
10.00Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
10.00Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
10.00Single9AUCCalcitonin gene-related peptide-19AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
10.00Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
10.00Single9JH5C16:0 Ceramide9JH5-CysLT2-C16:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Single9M1HProstaglandin E29M1H-EP1-Prostaglandin E2-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Single9M54Neuropeptide VF9M54-NPFF2-Neuropeptide VF-Gi1/β1/γ2
10.00Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
10.00Consensuscck_onOrthosteric Ligandccka_on cckb_on
10.00Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
10.00Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
10.00Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
10.00Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
10.00Consensusglp1_onOrthosteric Ligand7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
10.00Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
10.00Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
10.00Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
9.68Consensusglp1_on_gpOrthosteric Ligand7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
9.52Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
9.52Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
9.52Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
9.52Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
9.52Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
9.52Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
9.52Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
9.52Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
9.52Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
9.52Single8QJ2pN1628QJ2-MC4-pN162-Gs
9.52Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
9.52Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
9.52Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
9.52Single9CM7TUG-13759CM7-FFA2-TUG-1375-AZ-1729-Gi1/β1/γ2
9.52Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
9.52Single9JH6C20:0 Ceramide9JH6-CysLT2-C20:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
9.52Single9NS9TUG-13759NS9-FFA2-TUG-1375-Compound 187-Gi1/β1/γ2
9.52Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
9.52Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
9.52Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
9.52Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
9.52Consensuskisspeptin_onOrthosteric Ligandkiss1_on
9.38Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
9.09Single4XT1Fractalkine4XT1-US28-Fractalkine
9.09Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
9.09Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
9.09Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
9.09Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
9.09Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
9.09Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
9.09Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
9.09Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
9.09Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
9.09Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
9.09Single8IEBA1LYA8IEB-GPR156-A1LYA
9.09Single8IEIA1LYA8IEI-GPR156-A1LYA
9.09Single8IEIA1LYA8IEI-GPR156-A1LYA
9.09Single8IEPA1LYA8IEP-GPR156-A1LYA
9.09Single8IEPA1LYA8IEP-GPR156-A1LYA
9.09Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
9.09Single8KIGSHU91198KIG-MC3-SHU9119-Ca
9.09Single8U4OCXCL128U4O-CXCR4-CXCL12-Gi1/β1/γ2
9.09Single8WKYPG-9348WKY-MC4-PG-934
9.09Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
9.09Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
9.09Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
9.09Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
9.09Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
9.09Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
9.09Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
9.09Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
9.09Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
9.09Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
9.09Consensuspth_onOrthosteric Ligandpth1_on pth2_on
9.09Consensussomatostatin_offOrthosteric Ligandsst2_off
8.82Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
8.82Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
8.70Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
8.70Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
8.70Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
8.70Single7SK5CXCL127SK5-ACKR3-CXCL12
8.70Single7XNACYN1548067XNA-SST2-CYN154806
8.70Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
8.70Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
8.70Single8IEBA1LYA8IEB-GPR156-A1LYA
8.70Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
8.70Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
8.70Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
8.70Single9IQRMuscarinic toxin 39IQR-α2a-Muscarinic toxin 3
8.70Single9IQSMuscarinic toxin 39IQS-M4-Muscarinic toxin 3
8.70Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
8.70Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
8.70Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
8.70Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
8.70Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
8.70Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
8.70Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
8.70Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
8.70Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
8.57Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
8.33Single3OE0CVX153OE0-CXCR4-CVX15
8.33Single3OE8IT1t3OE8-CXCR4-IT1t
8.33Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
8.33Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
8.33Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
8.33Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
8.33Single6W25SHU91196W25-MC4-SHU9119-Ca
8.33Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
8.33Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
8.33Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
8.33Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
8.33Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
8.33Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
8.33Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
8.33Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
8.33Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
8.33Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
8.33Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
8.33Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
8.33Consensusclass-b1_class-b2_cons_onOrthosteric Ligandclass-b1_on class-b2_on
8.33Consensusclass-b1_class-b2_cons_on_gpOrthosteric Ligandclass-b1_on_gp class-b2_on_gp
8.33Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
8.33Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
8.33Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
8.33Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
8.33Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
8.11Consensuspth_on_gpOrthosteric Ligandpth1_on_gp pth2_on_gp
8.00Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
8.00Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
8.00Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
8.00Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
8.00Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
8.00Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
8.00Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
8.00Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
8.00Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
8.00Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
8.00Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
8.00Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
8.00Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
8.00Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
8.00Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
8.00Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
7.69Single3OE6IT1t3OE6-CXCR4-IT1t
7.69Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
7.69Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
7.69Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
7.69Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
7.69Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/β1/γ2
7.69Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
7.69Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
7.69Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
7.69Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
7.69Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
7.69Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
7.69Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
7.69Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
7.69Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
7.69Consensuscalcitonin_onOrthosteric Ligandctlike_on
7.69Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
7.69Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
7.69Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
7.69Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
7.69Consensuspac_onOrthosteric Ligandpac1_on
7.50Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
7.41Single4XT3Fractalkine4XT3-US28-Fractalkine
7.41Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
7.41Single6FJ3PTH6FJ3-PTH1-PTH
7.41Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
7.41Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
7.41Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
7.41Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
7.41Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
7.41Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
7.41Consensuscalcitonin_on_gpOrthosteric Ligandctlike_on_gp
7.41Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
7.41Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
7.41Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
7.41Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
7.41Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
7.41Consensuspac_on_gpOrthosteric Ligandpac1_on_gp
7.14Single5L7IVismodegib5L7I-SMO-Vismodegib
7.14Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
7.14Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
7.14Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
7.14Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
7.14Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
7.14Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
7.14Single7XP6Strychnine7XP6-TAS2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
7.14Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
7.14Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
7.14Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab
7.14Single8W8XBeta-MSH8W8X-MC3-β-MSH-Ca-Gs/β1/γ2
7.14Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
7.14Consensusglp_onOrthosteric Ligandglp1_on glp2_on
7.14Consensusglp_on_gpOrthosteric Ligandglp1_on_gp glp2_on_gp
7.14Consensusgq_nucleotideOrthosteric Ligandgq_p2y
7.14Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
7.14Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
7.14Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
6.90Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
6.90Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
6.90Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
6.90Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
6.90Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
6.90Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
6.90Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
6.90Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
6.90Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
6.90Single9BQ3Cagrilintide9BQ3-CT (AMY2)-Cagrilintide-Gs/β1/γ2; RAMP2
6.90Single9BYOExendin-39BYO-GLP-1-Exendin-3-Gs/β1/γ2
6.90Consensusvip-pacap_onOrthosteric Ligandvpac_on pac_on
6.90Consensusvip-pacap_on_gpOrthosteric Ligandvpac_on_gp pac_on_gp
6.67Single3ODUIT1t3ODU-CXCR4-IT1t
6.67Single4K5YCP-3763954K5Y-CRF1-CP-376395
6.67Single5U09Taranabant5U09-CB1-Taranabant
6.67Single5ZKQABT-4915ZKQ-PAF-ABT-491
6.67Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
6.67Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
6.67Single7F8YDevazepide7F8Y-CCKA-Devazepide
6.67Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
6.67Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.67Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
6.67Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
6.67Single7VVOPTH7VVO-PTH1-PTH-Gs/β1/γ2
6.67Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
6.67Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
6.67Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
6.67Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
6.67Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
6.67Single8U4PAMD31008U4P-CXCR4-AMD3100-Gi1/β1/γ2
6.67Single8YYWAlpha-ketoglutarate8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
6.67Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
6.67Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
6.45Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
6.45Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
6.45Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
6.45Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
6.25Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
6.25Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
6.25Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
6.25Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
6.25Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
6.25Single7UTZDPPC7UTZ-TSH-TR1402-DPPC-Gs/β1/γ2
6.25Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
6.25Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
6.25Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
6.25Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
6.25Single8IYXYL-3658IYX-GPR34-YL-365
6.25Single8K2WAMG4878K2W-CXCR3-AMG487
6.25Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
6.25Single8K9LDamgo8K9L-μ-Damgo-BMS-986122-Gi3/β1/γ1
6.25Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
6.25Single9IXXLTD49IXX-CysLT2-LTD4-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25Single9JMDAzithromycin9JMD-Motilin-Azithromycin-chim(Gs-CtGq)/β1/γ2
6.25Single9K0KUTP9K0K-P2Y4-UTP-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25Single9K0XATP9K0X-P2Y2-ATP-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25Single9K20ATP9K20-P2Y2-ATP-chim(NtGi1-Go)/β1/γ2
6.25Single9KPDSA09KPD-TAS2R16-SA0-chim(Gs-CtGt3)/β1/γ2
6.25Single9M2FNeuropeptide FF9M2F-NPFF1-Neuropeptide FF-Gi1/β1/γ2
6.25Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
6.25Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
6.06Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
6.06Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
6.06Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
6.06Consensusglucagon_onOrthosteric Ligandglp_on gluc_on secretin_on gip_on
5.88Single4Z9GCP-3763954Z9G-CRF1-CP-376395
5.88Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
5.88Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
5.88Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
5.88Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
5.88Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
5.88Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
5.88Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
5.88Single8GTIBMK-C2058GTI-CRF1-BMK-C205
5.88Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
5.88Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
5.88Single8ZYYNeurotensin peptide 8-138ZYY-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
5.88Consensusglucagon_on_gpOrthosteric Ligandglp_on_gp gluc_on_gp secretin_on_gp gip_on_gp
5.88Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
5.56Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
5.56Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
5.56Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
5.56Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
5.56Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
5.56Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
5.56Single8GTGBMK-I1528GTG-CRF1-BMK-I152
5.56Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
5.56Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
5.56Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
5.56Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
5.56Single8ZYTNeurotensin peptide 8-138ZYT-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
5.56Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
5.56Single9KPFSA09KPF-TAS2R16-SA0-Gi1/β1/γ2
5.56Consensusadgrg2_onOrthosteric Ligand7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
5.56Consensusadgrg2_on_gpOrthosteric Ligand7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
5.56Consensusclass-b1_onOrthosteric Ligandglucagon_on vip-pacap_on pth_on crf_on calcitonin_on
5.56Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
5.56Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
5.56Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
5.56Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
5.56Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
5.26Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
5.26Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
5.26Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
5.26Single7F1TMIP-1a7F1T-CCR5-MIP-1a
5.26Single7R0CAVP7R0C-V2-AVP-Arrestin2
5.26Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
5.26Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
5.26Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.26Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.26Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
5.26Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
5.26Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
5.26Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
5.26Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
5.26Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
5.26Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
5.26Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
5.26Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Gi1/β1/γ1
5.26Single8Y73Peptide8Y73-μ-Peptide-MPAM-15-Gi1/β1/γ2
5.26Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
5.26Consensuslpa_onOrthosteric Ligandlpa1_on
5.26Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
5.26Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
5.26Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
5.00Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
5.00Single4PY02MeSATP4PY0-P2Y12-2MeSATP
5.00Single4XEENeurotensin4XEE-NTS1-Neurotensin
5.00Single4XESNeurotensin4XES-NTS1-Neurotensin
5.00Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
5.00Single6OS2TRV0266OS2-AT1-TRV026
5.00Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
5.00Single6YVRNTS8-136YVR-NTS1-NTS8-13
5.00Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
5.00Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
5.00Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
5.00Single8GTMBMK-C2038GTM-CRF1-BMK-C203
5.00Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
5.00Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
5.00Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
5.00Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
5.00Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
5.00Consensusclass-b1_on_gpOrthosteric Ligandglucagon_on_gp vip-pacap_on_gp pth_on_gp crf_on_gp calcitonin_on_gp
5.00Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
5.00Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
5.00Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
5.00Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
4.76Single4BUONeurotensin4BUO-NTS1-Neurotensin
4.76Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
4.76Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
4.76Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
4.76Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-SBI-553-chim(NtGi1-Go)/β1/γ2
4.76Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
4.76Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
4.76Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.76Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.76Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55Single6KNMJN241-96KNM-Apelin-JN241-9
4.55Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
4.55Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
4.55Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
4.55Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
4.55Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.55Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
4.55Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
4.55Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
4.55Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
4.55Single8XQJJN2418XQJ-Apelin-JN241
4.55Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
4.55Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
4.55Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
4.55Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
4.35Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
4.35Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
4.35Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
4.35Single8YWFRetatrutide8YWF-GLP-1-Retatrutide-chim(NtGi1-Gs)/β1/γ2
4.35Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35Single9BUECagrilintide9BUE-CT-Cagrilintide-Gs/β1/γ2
4.35Single9J0IUDP-Glucuronic acid9J0I-P2Y14-UDP-Glucuronic acid-Gi1/β1/γ2
4.35Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
4.17Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
4.17Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
4.17Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
4.17Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17Single9J0FNADH9J0F-P2Y14-NADH-Gi1/β1/γ2
4.17Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
4.00Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
4.00Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
4.00Single9M1OMorphine-Modulating Neuropeptide B9M1O-NPFF2-Morphine-Modulating Neuropeptide B-Gi1/β1/γ2
3.85Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
3.85Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
3.85Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
3.85Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ2
3.85Single9EBOGLP-1 (ACPC18)9EBO-GLP-1-GLP-1 (ACPC18)-Gs/β1/γ2
3.85Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
3.85Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
3.70Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
3.70Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
3.70Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
3.70Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
3.70Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
3.70Consensusvpac_onOrthosteric Ligandvpac1_on vpac2_on
3.57Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
3.57Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
3.57Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
3.57Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
3.57Single7SK3CXCL127SK3-ACKR3-CXCL12
3.57Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
3.57Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
3.57Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
3.57Consensusvpac_on_gpOrthosteric Ligandvpac1_on_gp vpac2_on_gp
3.45Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
3.45Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
3.45Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
3.45Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
3.45Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
3.45Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
3.33Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
3.33Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
3.33Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
3.23Single7RBTTirzepatide7RBT-GIP-Tirzepatide-LSN3556672-chim(NtGi1-Gs)/β1/γ2
3.12Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
3.03Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
3.03Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
3.03Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
3.03Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
2.94Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
2.94Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
2.94Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2

Consensus Members
Id Members
opsins_on_gp rhodopsin_on_gp
opsin1lw_on_gp
Net Summary
Imin 2.15
Number of Linked Nodes 890
Number of Links 1162
Number of Hubs 223
Number of Links mediated by Hubs 820
Number of Communities 21
Number of Nodes involved in Communities 304
Number of Links involved in Communities 478
Path Summary
Number Of Nodes in MetaPath 161
Number Of Links MetaPath 160
Number of Shortest Paths 1779988
Length Of Smallest Path 3
Average Path Length 26.2076
Length of Longest Path 54
Minimum Path Strength 0.6825
Average Path Strength 5.02869
Maximum Path Strength 32.5025
Minimum Path Correlation 0.7
Average Path Correlation 0.974615
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.22222
Average % Of Corr. Nodes 41.4444
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 61.4587
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following consensuses:
IdComponents
class-a_on_gpsensory_on_gp
alicarboxylic_on_gp
amine_on_gp
lipid_on_gp
nucleotide_on_gp
peptide_on_gp
protein_on_gp
sensory_offon_gpsensory_on_gp
sensory_on



You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download sensory_on_gp.zip



You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.



You can also  read or  download a guide explaining the meaning of all files and numerical data.