Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
1G.HN.45 2.05417404
2G.S1.01 4.84083406
3G.S1.02 5.11917445
4G.S1.05 4.2325409
5G.H1.01 4.48233549
6G.H1.04 3.97367507
7G.H1.07 3.915424129
8G.H1.08 3.96542448
9G.S2.06 6.08333449
10G.S2.08 7.60292445
11G.s2s3.01 4.3775444
12G.S3.01 5.32125444
13G.S3.03 6.80267547
14G.S3.04 8.43917416
15G.S3.05 3.685447
16G.S3.06 7.60667515
17G.S3.07 4.23833449
18G.s3h2.03 3.61458419
19G.H2.04 2.61533519
20G.H2.06 5.26595719
21G.H2.07 4.552519
22G.H2.08 3.73167418
23G.H2.09 4.91542418
24G.h2s4.01 6.22419
25G.h2s4.02 4.59292417
26G.S4.04 4.79417409
27G.s4h3.03 3.15125408
28G.s4h3.04 4.49754185
29G.s4h3.08 1.52167408
30G.H3.09 3.91667609
31G.H3.15 3.39167418
32G.H3.17 5.653515
33G.H3.18 5.66458419
34G.S5.05 4.063335129
35G.S5.06 4.87408
36G.HG.04 2.95792409
37G.HG.14 1.79708405
38G.hgh4.01 3.49208406
39G.hgh4.02 5.157675197
40G.hgh4.05 6.72708407
41G.H4.10 5.282924196
42G.H4.12 4.091254205
43G.h4s6.12 4.07667444
44G.S6.02 5.35917407
45G.H5.03 5.523675128
46G.H5.05 4.5625445
47G.H5.08 4.83133548
48G.H5.17 3.79958445
49G.H5.25 4.67567507
50G.H5.26 5.57367505
51b.1x1 1.90792404
52b.1x11 4.27542408
53b.h2x1 4.39042405
54b.h2x5 3.2875405
55b.lhb1x3 2.83833502
56b.lhb1x6 3.74333593
57b.lhb1x9 3.0625403
58b.lhb1x11 4.311254104
59b.l1x3 8.95233539
60b.b2x1 6.568518
61b.b2x5 5.42476737
62b.b3x3 3.66167488
63b.l3x2 4.64533539
64b.b4x3 4.23333487
65b.b4x5 3.689587
66b.b4x6 9.58639639
67b.l4x2 11.1054434
68b.b5x2 4.1255177
69b.b5x3 5.92278639
70b.b5x5 5.4375485
71b.b5x7 5.2025407
72b.l5x1 3.95067588
73b.l5x5 7.25952719
74b.b6x1 3.225409
75b.b6x5 3.89438886
76b.l6x5 5.5654154
77b.b7x1 4.830675154
78b.b7x4 3.73375488
79b.l7x4 3.5275419
80b.b8x3 3.94083406
81b.b8x4 4.66889686
82b.l8x1 4.21375485
83b.l8x5 2.714174213
84b.b9x4 5.53708409
85b.l9x3 6.84778619
86b.l9x6 4.56952718
87b.b10x3 3.49417418
88b.b10x5 4.16167609
89b.b11x2 4.45083407
90b.b11x4 5.707519
91b.b11x5 4.11042456
92b.l11x2 8.02583419
93b.b12x3 3.27708458
94b.b12x6 7.60357718
95b.b13x7 7.31133557
96b.l13x3 6.95556659
97b.l13x7 4.2825459
98b.b14x3 4.15458455
99b.b15x1 5.81528659
100b.b15x2 6.43917466
101b.b15x3 4.58125459
102b.l15x2 5.281559
103b.b16x4 7.97167556
104b.b16x5 4.5025405
105b.b16x6 7.93056658
106b.l16x3 4.704174233
107b.b17x7 7.83625468
108b.l17x3 8.72361669
109b.l17x6 6.39417419
110b.b18x3 4.30433568
111b.b18x5 4.89708405
112b.l18x1 5.742627136
113b.l18x2 5.722084137
114b.b19x2 6.28786766
115b.b19x4 5.434568
116b.l19x2 6.332569
117b.b20x4 10.2007568
118b.b20x6 7.58566
119b.b21x1 7.94625467
120b.b21x5 4.995404
121b.b21x7 4.8605
122b.b22x5 5.218335137
123b.l22x5 6.19417699
124b.b23x1 3.88708405
125b.b23x6 6.856676147
126b.l23x1 6.66458416
127b.b24x4 7.746674146
128b.b24x6 6.152675148
129b.b24x7 6.57458499
130b.l24x3 3.98667495
131b.l25x3 8.399335109
132b.l25x6 11.8138418
133b.b26x3 3.45833406
134b.l27x1 10.336719
135b.l27x2 8.027084109
136b.b28x3 4.069537
137b.b28x4 7.727084106
138b.b28x6 7.740566109
139g.h1x1 3.91292402
140g.l1x4 5.36125408
141g.h2x11 7.146674136
142g.ctx3 6.86875409
143g.ctx4 3.72792407
144g.ctx6 3.16361696
145g.ctx14 3.72083439
146g.ctx15 6.02292439
147g.ctx16 5.17381738
148NT.F10 3.25708407
149NT.I13 2.97042403
150NT.K16 4.601335254
1511x30 3.49426
1521x31 3.62292425
1531x35 4.656525
1541x42 4.125407
1551x43 6.4775407
1561x50 4.456509
1572x41 2.24167407
1582x44 3.74967506
1592x50 5.876675119
1602x60 4.56708426
1612x64 6.00233526
162E1.W91 4.8269724
163E1x50 8.025566289
1643x30 6.174174166
1653x32 5.3175426
1663x34 5.108335165
1673x35 5.13417409
1683x36 5.66958428
1693x37 6.08208427
1703x40 4.5428
1713x51 7.212577
1723x52 4.31867575
1733x53 5.99472678
1743x55 6.76792478
175I2x51 4.94167446
1764x53 3.15417407
1774x54 2.560424164
1784x59 4.46167427
179E2.L176 3.50667424
180E2.F180 6.6525623
1815x40 6.00708425
1825x461 4.79525
1835x47 6.15472628
1845x51 4.10867527
1855x54 2.47083408
1865x60 4.90292474
1875x62 3.33833405
1885x65 3.42583408
1895x68 4.27792445
190I3.M220 4.803543
191I3.H223 3.55067544
1926x37 3.01583407
1936x44 4.51056629
1946x48 6.416528
1956x55 7.31233525
1966x59 4.80625425
1977x27 3.73233502
1987x34 7.61625424
1997x42 4.05907927
2007x49 5.133675119
2017x50 3.77067509
2027x52 2.338754118
2037x53 4.858817119
2047x54 4.882867117
205Lig 6.780911120
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1b.l1x3 b.l3x2 12.83663.78YesYes399
2b.b3x2 b.b4x6 23.87835.88167NoYes359
3b.b2x3 b.b3x2 23.72152.58833NoNo365
4b.b26x2 b.b2x3 46.26094.86NoNo076
5b.b26x1 b.b26x2 46.60752.58NoNo097
6b.b26x1 b.l27x1 46.96075.14667NoYes099
7b.b2x1 b.l27x1 21.00925.94833YesYes189
8b.b2x1 b.l3x1 10.187913.1517YesNo089
9b.l3x1 b.l5x5 10.24686.025NoYes099
10G.H2.09 b.l27x1 20.48654.05667YesYes189
11G.H2.09 G.H3.17 15.80286.34667YesYes185
12G.H3.15 G.H3.17 41.3284.14333YesYes185
13G.H2.08 G.H3.15 41.17752.83167YesYes188
14G.H2.04 G.H2.08 41.0672.71333YesYes198
15G.H2.04 G.H3.08 82.52193.23833YesNo099
16G.H3.08 G.S4.04 82.514.66833NoYes099
17G.H3.09 G.S4.04 99.80758.21667YesYes099
18G.H3.09 G.H4.15 99.48973.57333YesNo098
19G.H3.06 G.H4.15 99.98132.90333NoNo068
20G.H3.06 G.hgh4.02 99.94934.18833NoYes067
21G.H4.10 G.hgh4.02 99.99253.30833YesYes1967
22G.H4.10 G.hgh4.05 10010.4233YesYes067
23G.H4.05 G.hgh4.05 99.91733.74NoYes047
24G.H4.04 G.H4.05 99.83452.115NoNo044
25G.H4.03 G.H4.04 99.80692.43167NoNo044
26G.H4.03 G.HG.01 99.75182.39NoNo045
27G.HG.01 G.s6h5.02 99.72424.04167NoNo057
28G.s6h5.02 G.s6h5.05 99.6663.37NoNo079
29b.l25x6 b.l27x1 22.619124.1567YesYes189
30G.H3.17 b.l25x6 28.4254YesYes158
31G.h2s4.01 b.l5x5 17.39429.18667YesYes199
32G.S1.05 G.h2s4.01 18.78338.12167YesYes099
33G.S1.05 G.S1.07 19.2753.46YesNo099
34G.S1.07 G.S4.04 19.28253.24833NoYes099
35G.H5.03 G.s6h5.05 91.65874.48833YesNo1289
36G.H5.03 G.S5.05 91.52272.82YesYes1289
37G.H2.09 G.H2.10 17.48164.17833YesNo187
38G.H2.10 b.b6x1 28.83312.97NoYes079
39b.b6x1 b.l9x6 33.0734.59167YesYes098
40G.s3h2.03 b.l9x6 42.51152.81833YesYes198
41G.H2.10 b.b2x1 11.3654.48167NoYes178
42G.H2.06 b.l9x6 74.93713.58YesYes198
43G.H2.06 b.l17x6 37.25846.685YesYes199
44G.H2.06 b.b18x1 37.25853.03333YesNo099
45G.S5.03 G.S5.05 92.50273.34833NoYes089
46G.H5.10 G.S5.03 92.42343.25NoNo068
47G.H5.10 G.S6.02 92.3846.00667NoYes067
48G.S6.02 G.h4s6.12 89.89836.54667YesYes074
49G.H5.17 G.h4s6.12 88.66143.15YesYes454
50G.H5.17 G.H5.26 89.09023.1YesYes055
51G.H5.20 G.H5.26 89.72234.87NoYes095
52G.H5.20 G.H5.25 90.12163.46NoYes097
533x50 G.H5.25 94.2089.71833NoYes097
54b.l17x6 b.l19x1 37.21516.875YesNo099
55b.l17x5 b.l19x1 74.07842.94167NoNo069
56b.l17x5 b.l19x2 73.80935.39833NoYes069
57b.l17x3 b.l19x2 58.16884.2YesYes699
58b.b19x4 b.l17x3 42.80939.125YesYes689
59b.b19x2 b.b19x4 21.41812.59YesYes668
60b.b17x7 b.b19x2 13.157211.6117YesYes686
61b.b17x7 b.b21x1 50.22373.185YesYes687
62b.1x19 b.b21x1 44.55637.74NoYes067
63b.1x15 b.1x19 39.97762.50667NoNo076
64b.1x12 b.1x15 37.68762.90667NoNo067
65b.1x12 g.h1x11 27.37593.055NoNo069
66b.1x11 g.h1x11 23.93645.53667YesNo089
67b.b18x1 b.l19x1 37.132410.5467NoNo099
68b.b19x4 b.b20x6 13.40787.34833YesYes686
69b.b17x7 b.b20x6 39.35778.93333YesYes686
70b.b20x4 b.l17x3 14.256816.3617YesYes689
71b.b20x4 b.b20x6 26.80855.87833YesYes686
72b.b20x2 b.l19x2 14.81816.02167NoYes069
73b.b20x2 b.b20x4 14.25856.25167NoYes068
74b.lhb1x11 b.lhb1x9 11.14082.91833YesYes043
75b.b22x1 b.l25x6 16.96093.01833NoYes188
76b.b22x1 b.b22x2 16.86253.2NoNo088
77b.b22x2 b.b26x3 16.66884.50333NoYes086
78b.b2x4 b.b6x5 10.68083.45167NoYes066
79b.b10x4 b.b2x4 10.474513.5433NoNo066
80b.b8x2 b.b8x4 10.26885.30167NoYes086
81b.b8x2 b.b9x3 10.36045.03167NoNo086
82b.l5x3 b.l5x5 11.00442.68NoYes089
83b.b9x3 b.l7x5 10.5544.78333NoNo066
84b.l7x3 b.l7x5 10.76783.73333NoNo096
85b.l5x3 b.l7x3 10.88389.32333NoNo089
86b.l11x1 b.l9x6 10.84466.75667NoYes198
87b.b11x6 b.l11x1 10.73013.40167NoNo199
88b.b10x2 b.b10x4 10.26812.78667NoNo066
89b.b10x2 b.b14x3 10.06165.28833NoYes065
90b.l23x1 b.l25x6 15.171916.08YesYes168
91b.l21x7 b.l23x1 14.86913.88833NoYes056
92b.l21x7 b.l23x2 14.47317.26167NoNo058
93b.b23x6 b.l23x2 13.68894.6YesNo078
94b.b23x6 b.b24x6 11.92646.91333YesYes1478
95b.1x11 b.1x7 19.34862.65167YesNo088
96b.1x7 g.h1x8 17.0541.90167NoNo087
97b.1x4 g.h1x8 14.75881.49NoNo087
98b.1x4 g.h1x5 12.46322.42833NoNo086
99g.h1x1 g.h1x5 10.1676.265YesNo026
1003x50 7x53 94.10235.145NoYes099
1013x43 7x53 41.72994.68667NoYes099
1023x43 6x44 41.64152.64NoYes099
1033x40 6x44 15.78442.72333YesYes289
1043x40 5x461 15.48914.55833YesYes285
1053x36 Lig 26.77311.2083YesYes280
106E1.W91 Lig 32.06983.22833YesYes240
1076x44 6x48 24.33117.68167YesYes298
1086x48 7x41 48.66714.97167YesNo288
1093x36 7x41 17.97294.31YesNo288
1107x49 7x53 47.52594.40833YesYes1199
1117x45 7x49 24.62167.18NoYes099
1126x48 7x45 24.44079.06167YesNo089
1137x41 7x42 30.49073.32667NoYes287
1147x42 Lig 27.36227.67833YesYes270
1152x50 7x49 21.29876.87333YesYes1199
1162x50 7x46 20.69548.34333YesNo098
1172x53 7x46 20.59893.25167NoNo078
1182x53 7x42 15.87163.71NoYes077
119E2x51 Lig 10.0115.44667NoYes240
1203x32 7x42 10.04373.125YesYes267
1212x56 3x28 12.58922.7NoNo065
1222x63 E1x50 14.12027.72167NoYes059
1232x63 E1.W91 14.79114.70833NoYes054
1243x25 E1x50 11.21647.40167NoYes2899
1253x25 E2.P168 10.09593.13833NoNo094
126G.H2.07 G.s3h2.03 42.77644.93YesYes199
127G.H2.04 G.H2.07 41.50154YesYes199
128b.b2x3 b.b2x5 22.19764.26667NoYes367
129b.b21x7 b.b24x6 11.05356.43YesYes058
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
E1.W91NT.R223.666672YesNo0012
1x311x354.758332YesYes5522
1x312x643.831672YesYes5621
1x31E1.W913.5252YesYes5021
1x352x649.963332YesYes5621
1x427x425.051670YesYes7721
2x563x324.4950NoYes6621
2x577x424.688330NoYes8721
2x602x644.493332YesYes6611
2x603x324.613332YesYes6611
2x607x423.323332YesYes6711
2x63E1.W914.708330NoYes5021
2x64E1.W915.3052YesYes6011
2x64Lig6.418332YesYes6010
E1.W91E2x513.501672YesNo0411
7x35E1.W919.853330NoYes5021
E1.W91Lig3.228332YesYes0010
3x29E2.M1672.591672NoNo5012
3x29E2x522.752NoNo5411
3x29Lig6.768332NoYes5010
3x327x423.1252YesYes6711
3x32Lig9.036672YesYes6010
3x367x414.312YesNo8812
3x367x423.092YesYes8711
3x36Lig11.20832YesYes8010
E2x51Lig5.446672NoYes4010
E2x52Lig6.3152NoYes4010
5x44E2.F1808.573330NoYes6021
6x55E2.F1803.3852YesYes5021
7x34E2.F1808.396672YesYes4021
7x38E2.F1803.451672NoYes5011
E2.F180Lig7.058332YesYes0010
5x445x4613.693330NoYes6522
6x557x3412.82832YesYes5422
7x347x384.873332YesNo4521
7x38Lig5.593332NoYes5010
7x42Lig7.678332YesYes7010
2x537x423.710NoYes7721
2x60Lig5.838332YesYes6010
3x365x4614.072YesYes8512
E2.L176E2x513.003332YesNo0421
5x40E2x525.812YesNo5421
5x40E2.F1809.052YesYes5021
7x417x423.326672NoYes8721
1x397x422.538330NoYes8721

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
100.00Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
100.00Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
100.00Consensushca_on_gpOrthosteric Ligandhca2_on_gp
91.67Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
91.67Single9CIBFCH-22964139CIB-HCA2-FCH-2296413
90.91Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
90.91Consensushca_onOrthosteric Ligandhca2_on
84.62Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
84.62Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
83.33Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
83.33Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
83.33Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
83.33Single8K5DGSK2560738K5D-HCA2-GSK256073
83.33Single9IZCMK19039IZC-HCA2-MK1903-Gi1/β1/γ2
76.92Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
76.92Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
75.00Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
75.00Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
75.00Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
75.00Single8K5CAcipimox8K5C-HCA2-Acipimox
72.73Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
72.73Single8K5BNiacin8K5B-HCA2-Niacin
72.73Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
69.23Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
69.23Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
66.67Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
66.67Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
66.67Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
66.67Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
66.67Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
63.64Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
62.50Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
61.54Single8IHKAcifran8IHK-HCA3-Acifran
58.82Single9IZASCH9002719IZA-HCA2-SCH900271-Gi1/β1/γ2
58.33Single3OE9IT1t3OE9-CXCR4-IT1t
58.33Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
58.33Single9IZDCHBA9IZD-HCA1-CHBA-Gi1/β1/γ2
57.14Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
56.25Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
55.56Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
55.56Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
55.00Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
53.85Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
53.85Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
53.85Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
53.85Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
53.85Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
53.85Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
53.33Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
53.33Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
52.94Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
52.63Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
52.63Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
50.00Single3OE6IT1t3OE6-CXCR4-IT1t
50.00Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
50.00Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
50.00Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
50.00Single9M0RNeuropeptide VF9M0R-NPFF1-Neuropeptide VF-Gi1/β1/γ2
50.00Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
50.00Consensusrelaxin_onOrthosteric Ligandrxfp4_on
50.00Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
47.83Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
47.62Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
47.62Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
47.37Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
47.37Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
47.06Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
47.06Single7K15MKD0467K15-BLT1-MKD046-Na
47.06Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
47.06Single8XYIVUF106618XYI-CXCR3-VUF10661
46.67Single4YAYZD-71554YAY-AT1-ZD-7155
46.67Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
46.67Single7UL4Alvimopan7UL4-μ-Alvimopan
46.67Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
46.67Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
46.67Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
46.15Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
46.15Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
46.15Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
46.15Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
45.83Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
45.45Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
45.45Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
45.00Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
45.00Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
45.00Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
45.00Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
45.00Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
45.00Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
44.44Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
44.44Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
44.44Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
44.44Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
44.44Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
44.44Consensusprostanoid_offOrthosteric Ligandep_off dp_off
43.75Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
43.75Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
43.75Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
43.75Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
43.75Single8XYKVUF106618XYK-CXCR3-VUF10661-Go/β1/γ2
43.75Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
43.75Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
43.75Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
43.75Consensusblt_offOrthosteric Ligandblt1_off
43.75Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
43.75Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
43.48Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
42.86Single3ODUIT1t3ODU-CXCR4-IT1t
42.86Single5ZKQABT-4915ZKQ-PAF-ABT-491
42.86Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
42.86Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
42.86Single8Y0HVUF114188Y0H-CXCR3-VUF11418
42.86Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go/β1/γ2
42.86Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
42.86Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
42.86Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
42.11Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
42.11Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
42.11Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
42.11Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
42.11Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
41.67Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
41.67Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
41.67Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
41.67Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
41.67Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
41.18Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
41.18Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
41.18Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
41.18Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
41.18Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
41.18Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
41.18Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
40.91Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
40.91Single8ZBISomatostatin-148ZBI-SST3-Somatostatin-14-Gi1/β1/γ2
40.91Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
40.91Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
40.00Single2YDOAdenosine2YDO-A2A-Adenosine
40.00Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
40.00Single4XT1Fractalkine4XT1-US28-Fractalkine
40.00Single4ZJCSB-6740424ZJC-OX1-SB-674042
40.00Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
40.00Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
40.00Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
40.00Single6TPGEMPA6TPG-OX2-EMPA
40.00Single6V9SGTPL114036V9S-OX1-GTPL11403
40.00Single6ZG9GSK10347026ZG9-M1-GSK1034702
40.00Single7F61PF-036547467F61-H3-PF-03654746
40.00Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
40.00Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
40.00Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
40.00Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
40.00Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
40.00Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
40.00Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
40.00Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
40.00Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
40.00Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
40.00Single9JFUNE52-QQ579JFU-GPR4-NE52-QQ57
40.00Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
40.00Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
40.00Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
39.13Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
39.13Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
39.13Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
39.13Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
39.13Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
38.89Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
38.89Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
38.89Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
38.89Single7DFPSpiperone7DFP-D2-Spiperone
38.89Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
38.89Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
38.89Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
38.89Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
38.89Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
38.89Single9DGIZ85267113509DGI-CB1-Z8526711350
38.89Single9GL2Befiradol9GL2-5-HT1A-Befiradol-Gs/β1/γ2
38.89Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
38.89Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
38.89Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
38.89Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
38.89Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
38.89Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
38.89Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
38.46Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
38.46Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
38.46Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
38.46Consensusbombesin_onOrthosteric Ligandbb2_on
38.46Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
38.46Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
38.10Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
38.10Single7XNACYN1548067XNA-SST2-CYN154806
38.10Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
38.10Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
38.10Single9E82SDF-1-beta9E82-ACKR3-SDF-1-β-Arrestin2
38.10Single9IQVMuscarinic toxin 39IQV-Alpha1A-Muscarinic toxin 3
38.10Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
38.10Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
38.10Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
37.50Single2Y04Salbutamol2Y04-β1-Salbutamol
37.50Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
37.50Single4XT3Fractalkine4XT3-US28-Fractalkine
37.50Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
37.50Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
37.50Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
37.50Single6TOTLemborexant6TOT-OX1-Lemborexant
37.50Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
37.50Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
37.50Single7V3ZCP559407V3Z-CB1-CP55940
37.50Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
37.50Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
37.50Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
37.50Single8PJKST1718PJK-5-HT1A-ST171-Gi1/β1/γ1
37.50Single8T1WCVN4248T1W-GPR6-CVN424
37.50Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
37.50Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
37.50Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
37.50Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
37.50Single9KFJPubChem 1383196749KFJ-RXFP3-PubChem 138319674-Gi2/β1/γ2
37.50Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
37.50Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
37.50Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
37.50Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
36.84Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
36.84Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
36.84Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
36.84Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
36.84Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
36.84Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
36.84Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
36.84Single9AS02-bromo-LSD9AS0-5-HT2A-2-bromo-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
36.84Single9M54Neuropeptide VF9M54-NPFF2-Neuropeptide VF-Gi1/β1/γ2
36.84Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
36.84Consensuscck_onOrthosteric Ligandccka_on cckb_on
36.84Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
36.84Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
36.84Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
36.84Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
36.84Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
36.36Single8GEJConstrained Epinephrine8GEJ-β2-Constrained Epinephrine-Gs/β1/γ2
36.36Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
36.36Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
36.36Consensusangiotensin_onOrthosteric Ligandat1_on
36.36Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
36.36Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
36.36Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
36.36Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
36.36Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
36.36Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
36.36Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
36.36Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
36.00Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
36.00Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
36.00Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
35.71Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
35.71Single9LMPNE52-QQ579LMP-GPR4-NE52-QQ57
35.71Consensusgq_nucleotideOrthosteric Ligandgq_p2y
35.71Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
35.29Single2Y03Isoprenaline2Y03-β1-Isoprenaline
35.29Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
35.29Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
35.29Single5WQCEMPA5WQC-OX2-EMPA
35.29Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
35.29Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
35.29Single6D26Fevipiprant6D26-DP2-Fevipiprant
35.29Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
35.29Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
35.29Single6TP6Filorexant6TP6-OX1-Filorexant
35.29Single7C4SS1P7C4S-S1P3-S1P
35.29Single7C61Ergotamine7C61-5-HT1B-Ergotamine
35.29Single7LD3Adenosine7LD3-A1-Adenosine-MIPS521-Gi2/β1/γ2
35.29Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
35.29Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
35.29Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
35.29Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
35.29Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
35.29Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
35.29Single8WGBVU01550418WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
35.29Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
35.29Single9EE8Adenosine9EE8-A2A-Adenosine-Gs/β1/γ2
35.29Single9F33FOB02-04A9F33-D3-FOB02-04A-Go/β1/γ2
35.29Single9I52A1IZU9I52-D1-A1IZU-Gs/β1/γ2
35.29Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
35.29Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
35.29Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
35.29Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
35.29Consensusdp_offOrthosteric Liganddp2_off
35.29Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
35.29Consensusep_offOrthosteric Ligandep4_off
35.29Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
35.29Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
35.29Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
35.29Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
35.29Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
35.29Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
35.29Consensustrace-amine_onOrthosteric Ligandta1_on
35.00Single4UG2CGS216804UG2-A2A-CGS21680
35.00Single5ZTYAM102575ZTY-CB2-AM10257
35.00Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
35.00Single7SK9CCX6627SK9-ACKR3-CCX662
35.00Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
35.00Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
35.00Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
35.00Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
35.00Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
35.00Single8Y72Peptide8Y72-μ-Peptide-BMS-986122-Gi1/β1/γ2
35.00Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
35.00Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
35.00Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
35.00Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
35.00Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
35.00Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
34.78Single6JODAngiotensin II6JOD-AT2-Angiotensin II
34.78Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
34.78Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
34.78Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
34.78Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
34.78Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
34.78Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
34.78Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
34.78Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
34.78Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
34.78Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
34.78Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
34.78Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
34.78Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
34.78Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
34.78Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
34.62Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
34.62Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
34.62Consensusbradykinin_onOrthosteric Ligandbk2_on
34.62Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
34.62Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
33.33Single2YDVNECA2YDV-A2A-NECA
33.33Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
33.33Single4DJHJDTic4DJH-κ-JDTic
33.33Single4S0VSuvorexant4S0V-OX2-Suvorexant
33.33Single4UHRCGS216804UHR-A2A-CGS21680
33.33Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
33.33Single5G53NECA5G53-A2A-NECA-Gs
33.33Single5WS3EMPA5WS3-OX2-EMPA
33.33Single5XR8AM8415XR8-CB1-AM841
33.33Single6B73MP11046B73-κ-MP1104
33.33Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
33.33Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
33.33Single6H7JIsoprenaline6H7J-β1-Isoprenaline
33.33Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
33.33Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
33.33Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
33.33Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
33.33Single6TODEMPA6TOD-OX1-EMPA-Na
33.33Single6TPJSuvorexant6TPJ-OX2-Suvorexant
33.33Single6TQ7SB-3348676TQ7-OX1-SB-334867
33.33Single7B6WCyclazosin7B6W-α1b-Cyclazosin
33.33Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
33.33Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
33.33Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
33.33Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
33.33Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
33.33Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
33.33Single7F8XNN90567F8X-CCKA-NN9056
33.33Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
33.33Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
33.33Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
33.33Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
33.33Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
33.33Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
33.33Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
33.33Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
33.33Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
33.33Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
33.33Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
33.33Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
33.33Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
33.33Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
33.33Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
33.33Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
33.33Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
33.33Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
33.33Single8E0GBU728E0G-μ-BU72
33.33Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
33.33Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
33.33Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
33.33Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
33.33Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
33.33Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
33.33Single8GNGIstradefylline8GNG-A2A-Istradefylline
33.33Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
33.33Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
33.33Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
33.33Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
33.33Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
33.33Single8IWESpermidine8IWE-TA9-Spermidine
33.33Single8PKMBefiradol8PKM-5-HT1A-Befiradol-Gi1/β1/γ1
33.33Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
33.33Single8U4OCXCL128U4O-CXCR4-CXCL12-Gi1/β1/γ2
33.33Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
33.33Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
33.33Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
33.33Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
33.33Single8WDTphotoNECA8WDT-A2A-photoNECA
33.33Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
33.33Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
33.33Single8YYWAlpha-ketoglutarate8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
33.33Single8YYWAlpha-ketoglutarate8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
33.33Single8ZBJSomatostatin-148ZBJ-SST5-Somatostatin-14-Gi1/β1/γ2
33.33Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
33.33Single9BUYLM1899BUY-β2-LM189-Gi1/β1/γ2
33.33Single9EGOYVF9EGO-CB1-YVF-Gi1/β1/γ2
33.33Single9I54A1IZV9I54-D1-A1IZV-Gs/β1/γ2
33.33Single9IK9SST analogue9IK9-SST1-SST analogue-Gi1/β1/γ2
33.33Single9KPESA09KPE-TAS2R16-SA0-Gi1/β1/γ2
33.33Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
33.33Consensusa2_onOrthosteric Liganda2b_on
33.33Consensusa2_on_gpOrthosteric Liganda2b_on_gp
33.33Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
33.33Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
33.33Consensusalpha2_offOrthosteric Ligandalpha2c_off
33.33Consensusangiotensin_offOrthosteric Ligandat1_off
33.33Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
33.33Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
33.33Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
33.33Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
33.33Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
33.33Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
33.33Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
33.33Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
33.33Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
33.33Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
33.33Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
33.33Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
33.33Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
33.33Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
33.33Consensuslpl_onOrthosteric Ligands1p_on lpa_on
33.33Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
33.33Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
33.33Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Consensusorexin_offOrthosteric Ligandox2_off ox1_off
33.33Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
33.33Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
33.33Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
33.33Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
33.33Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
33.33Consensussomatostatin_offOrthosteric Ligandsst2_off
33.33Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
33.33Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
32.00Single6FJ3PTH6FJ3-PTH1-PTH
32.00Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
32.00Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
32.00Single9KFKRelaxin-39KFK-RXFP4-Relaxin-3-Gi2/β1/γ2
32.00Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
32.00Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
32.00Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
32.00Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
32.00Consensussecretin_onOrthosteric Ligand7D3S-Secretin-Secretin-Gs/β1/γ2
31.82Single3QAKUK-4320973QAK-A2A-UK-432097
31.82Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
31.82Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
31.82Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
31.82Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
31.82Single9KFIRelaxin-39KFI-RXFP3-Relaxin-3-Gi2/β1/γ2
31.82Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
31.82Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
31.58Single4AMIBucindolol4AMI-β1-Bucindolol
31.58Single4LDEBI1671074LDE-β2-BI167107
31.58Single4RWADIPP-NH24RWA-δ-DIPP-NH2
31.58Single5X33BIIL2605X33-BLT1-BIIL260
31.58Single6A93Risperidone6A93-5-HT2A-Risperidone
31.58Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
31.58Single6OS2TRV0266OS2-AT1-TRV026
31.58Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
31.58Single6ZG4HTL00099366ZG4-M1-HTL0009936
31.58Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
31.58Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
31.58Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
31.58Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
31.58Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
31.58Single7YITNalfurafine7YIT-κ-Nalfurafine
31.58Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
31.58Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
31.58Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
31.58Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
31.58Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
31.58Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
31.58Single9BJKNAM9BJK-μ-Naloxone-NAM
31.58Single9EBIPiclidenoson9EBI-A3A-Piclidenoson-chim(NtGi1L-Gs-CtGi1)/β1/γ2
31.58Single9GGGI-BOP9GGG-TXA2-I-BOP-chim(NtGi2L-Gs-CtGq)/β1/γ2
31.58Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
31.58Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
31.58Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
31.58Consensusalpha1_offOrthosteric Ligandalpha1a_off
31.58Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
31.58Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
31.58Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
31.58Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
31.58Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
31.58Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
31.58Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
31.58Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
31.58Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
31.58Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
31.58Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
31.58Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
31.58Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
31.58Consensuslpl_offOrthosteric Ligands1p_off lpa_off
31.58Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
31.58Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
31.58Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
31.58Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
31.25Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
31.25Single6KUXRS-799486KUX-α2a-RS-79948
31.25Single6PS0S-Carazolol6PS0-β2-S-Carazolol
31.25Single6PS4ICI118-5516PS4-β2-ICI118-551
31.25Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
31.25Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
31.25Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
31.25Single6TP3Nemorexant6TP3-OX1-Nemorexant
31.25Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
31.25Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
31.25Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
31.25Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
31.25Single7UL3Famotidine7UL3-H2-Famotidine
31.25Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
31.25Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
31.25Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
31.25Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
31.25Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
31.25Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
31.25Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
31.25Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
31.25Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
31.25Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.25Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
31.25Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
31.25Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
31.25Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
31.25Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
31.25Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
31.25Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
31.25Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
31.25Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
31.25Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.25Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.25Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.25Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
31.25Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
31.25Single8ZPMAMD0708ZPM-CXCR4-AMD070
31.25Single9AS5Mescaline9AS5-5-HT2A-Mescaline
31.25Single9AS6Mescaline9AS6-5-HT2A-Mescaline-chim(NtGi1-Gs-CtGq)/β1/γ2
31.25Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
31.25Single9JMDAzithromycin9JMD-Motilin-Azithromycin-chim(Gs-CtGq)/β1/γ2
31.25Single9K0KUTP9K0K-P2Y4-UTP-chim(NtGi1-Gs-CtGq)/β1/γ2
31.25Single9K0XATP9K0X-P2Y2-ATP-chim(NtGi1-Gs-CtGq)/β1/γ2
31.25Single9K20ATP9K20-P2Y2-ATP-chim(NtGi1-Go)/β1/γ2
31.25Single9M2FNeuropeptide FF9M2F-NPFF1-Neuropeptide FF-Gi1/β1/γ2
31.25Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
31.25Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
31.25Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
31.25Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
31.03Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
30.77Single3OE8IT1t3OE8-CXCR4-IT1t
30.77Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
30.77Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
30.77Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
30.77Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
30.77Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
30.77Single8WC5Tetramethylammonium Ion8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
30.77Single9BUCCagrilintide9BUC-CT-Cagrilintide-Gs/β1/γ2
30.77Single9EE9Adenosine9EE9-A2A-Adenosine-Gs/β1/γ2
30.77Consensusglp_onOrthosteric Ligandglp1_on glp2_on
30.77Consensusglp_on_gpOrthosteric Ligandglp1_on_gp glp2_on_gp
30.77Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
30.77Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
30.77Consensussecretin_on_gpOrthosteric Ligand7D3S-Secretin-Secretin-Gs/β1/γ2
30.43Single5WF5UK-4320975WF5-A2A-UK-432097
30.43Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
30.43Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
30.43Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
30.43Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
30.43Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
30.43Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
30.43Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
30.43Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
30.43Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
30.43Single9U4WGonadoliberin-19U4W-GnRH1-Gonadoliberin-1-chim(NtGi1L-Gs-CtGq)/β1/γ2
30.43Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
30.43Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
30.43Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
30.43Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
30.43Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
30.00Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
30.00Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
30.00Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
30.00Single5X93K-87945X93-ETB-K-8794
30.00Single6IBLArformoterol6IBL-β1-Arformoterol
30.00Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
30.00Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
30.00Single7EZCUKA7EZC-A2A-UKA
30.00Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
30.00Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
30.00Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
30.00Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
30.00Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
30.00Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
30.00Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
30.00Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
30.00Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
30.00Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
30.00Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
30.00Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
30.00Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
30.00Single8S2TIsoprenaline8S2T-β1-Isoprenaline-chim(NtGi1-Gs)/β1/γ2
30.00Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
30.00Single9DYEBuspirone9DYE-5-HT1A-Buspirone-Go/β1/γ2
30.00Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
30.00Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
30.00Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
30.00Consensuschemerin_onOrthosteric Ligandcml1_on
30.00Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
30.00Consensusendothelin_offOrthosteric Ligandetb_off
30.00Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
30.00Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
29.63Single6IGLIRL16206IGL-ETB-IRL1620
29.63Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
29.63Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
29.63Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
29.63Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
29.63Single9BYOExendin-39BYO-GLP-1-Exendin-3-Gs/β1/γ2
29.41Single3NY8ICI118-5513NY8-β2-ICI118-551
29.41Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
29.41Single4GBRS-Carazolol4GBR-β2-S-Carazolol
29.41Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
29.41Single4QKX35V4QKX-β2-35V
29.41Single5DHGC-355DHG-NOP-C-35
29.41Single5DHHSB-6121115DHH-NOP-SB-612111
29.41Single5TGZAM65385TGZ-CB1-AM6538
29.41Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
29.41Single6DRXLisuride6DRX-5-HT2B-Lisuride
29.41Single6GPSMK08126GPS-CCR2-MK0812
29.41Single6H7MSalbutamol6H7M-β1-Salbutamol
29.41Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
29.41Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/β1/γ2
29.41Single6PS1Timolol6PS1-β2-Timolol
29.41Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
29.41Single6XBM5LWE6XBM-SMO-5LWE-Gi1/β1/γ2
29.41Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
29.41Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
29.41Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
29.41Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
29.41Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
29.41Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
29.41Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
29.41Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
29.41Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
29.41Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
29.41Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
29.41Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
29.41Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
29.41Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
29.41Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
29.41Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
29.41Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
29.41Single7YXAONO-54306087YXA-S1P5-ONO-5430608
29.41Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
29.41Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
29.41Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
29.41Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
29.41Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
29.41Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
29.41Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
29.41Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.41Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.41Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.41Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.41Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.41Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.41Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.41Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.41Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.41Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.41Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
29.41Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
29.41Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
29.41Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
29.41Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
29.41Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
29.41Single8JJOAlprenolol8JJO-β2-Alprenolol
29.41Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
29.41Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
29.41Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
29.41Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
29.41Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.41Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.41Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.41Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.41Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.41Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.41Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.41Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
29.41Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
29.41Single9CHXS-Carazolol9CHX-β2-S-Carazolol
29.41Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
29.41Single9JGKBalovaptan9JGK-5-HT2B-Balovaptan
29.41Consensusa3_onOrthosteric Liganda3a_on
29.41Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
29.41Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
29.41Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
29.41Consensusblt_onOrthosteric Ligandblt1_on
29.41Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
29.41Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
29.41Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
29.41Consensusdopamine_offOrthosteric Ligandd2_off d3_off
29.41Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
29.41Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
29.41Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
29.41Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
29.41Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
29.41Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
29.41Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
29.41Consensusleukotriene_onOrthosteric Ligandblt_on
29.41Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
29.17Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
29.17Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
29.17Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
29.17Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
29.17Single9BLCCagrilintide backbone (non-acylated)9BLC-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
29.17Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
29.17Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
29.17Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
29.17Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
28.57Single3NY9ICI118-5513NY9-β2-ICI118-551
28.57Single5GLHEndothelin-15GLH-ETB-Endothelin-1
28.57Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
28.57Single5WF6UK-4320975WF6-A2A-UK-432097
28.57Single6IGKEndothelin-36IGK-ETB-Endothelin-3
28.57Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
28.57Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
28.57Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
28.57Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
28.57Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
28.57Single7XN9L-054,5227XN9-SST2-L-054,522
28.57Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
28.57Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
28.57Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
28.57Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
28.57Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
28.57Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
28.57Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
28.57Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
28.57Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
28.57Single9LRCHistamine9LRC-H4-Histamine
28.57Single9LREHistamine9LRE-H4-Histamine-Gi1/β1/γ2
28.57Single9MD1Buspirone9MD1-5-HT1A-Buspirone-Gz/β1/γ2
28.57Consensusclass-a_class-b1_cons_onOrthosteric Ligandclass-a_on class-b1_on
28.57Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
28.57Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
28.57Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
28.57Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
28.57Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
28.57Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
28.57Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
28.57Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
28.57Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
28.57Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
28.00Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
28.00Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
28.00Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
28.00Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
28.00Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
28.00Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
28.00Single8ZRTET-18ZRT-ETB-ET-1
28.00Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
28.00Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
28.00Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
28.00Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
28.00Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
28.00Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
28.00Consensuspac_onOrthosteric Ligandpac1_on
28.00Consensusvpac1_onOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
27.78Single2RH1S-Carazolol2RH1-β2-S-Carazolol
27.78Single2YCWS-Carazolol2YCW-β1-S-Carazolol
27.78Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
27.78Single5C1MBU725C1M-μ-BU72
27.78Single5D6LS-Carazolol5D6L-β2-S-Carazolol
27.78Single5JQHS-Carazolol5JQH-β2-S-Carazolol
27.78Single5T1ABMS-6815T1A-CCR2-BMS-681-PubChem 12093170
27.78Single5WIUNemonapride5WIU-D4-Nemonapride
27.78Single5WIVNemonapride5WIV-D4-Nemonapride-Na
27.78Single5X7DS-Carazolol5X7D-β2-S-Carazolol-Cmpd-15
27.78Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
27.78Single6GPXMK08126GPX-CCR2-MK0812
27.78Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
27.78Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
27.78Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
27.78Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
27.78Single6PS6Timolol6PS6-β2-Timolol
27.78Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
27.78Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
27.78Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
27.78Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
27.78Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
27.78Single7SINNPS-21437SIN-CaS-NPS-2143
27.78Single7SINNPS-21437SIN-CaS-NPS-2143
27.78Single7W41PD1762527W41-BB2-PD176252
27.78Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
27.78Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
27.78Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
27.78Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
27.78Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
27.78Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
27.78Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
27.78Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
27.78Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
27.78Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
27.78Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.78Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.78Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.78Single8JXSPF-61428JXS-D1-PF-6142
27.78Single8S4DCMF-0198S4D-Apelin-CMF-019
27.78Single8TF5Oleic acid8TF5-GPR6-Oleic acid
27.78Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
27.78Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.78Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.78Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
27.78Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
27.78Single9ARZ2-bromo-LSD9ARZ-5-HT2A-2-bromo-LSD
27.78Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
27.78Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
27.78Single9EHSLUF76029EHS-A3A-LUF7602
27.78Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
27.78Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
27.78Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
27.78Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
27.78Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
27.78Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
27.78Consensusa3_on_gpOrthosteric Liganda3a_on_gp
27.78Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
27.78Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
27.78Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
27.78Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
27.78Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
27.78Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
27.78Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
27.78Consensusamine_offonOrthosteric Ligandamine_off amine_on
27.78Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
27.78Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
27.78Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
27.78Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
27.78Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
27.78Consensusbombesin_offOrthosteric Ligandbb2_off
27.78Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
27.59Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
27.27Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
27.27Single4IARErgotamine4IAR-5-HT1B-Ergotamine
27.27Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
27.27Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
27.27Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
27.27Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
27.27Single7QA8Peptide7QA8-STE2-Peptide
27.27Single7QA8Peptide7QA8-STE2-Peptide
27.27Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
27.27Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
27.27Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
27.27Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
27.27Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
27.27Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
27.27Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
27.27Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
27.27Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
27.27Single9HB3Mambaquaretin-19HB3-V2-Mambaquaretin-1
27.27Single9M4TSilodosin9M4T-Alpha1A-Silodosin
27.27Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
26.92Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
26.92Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
26.92Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
26.92Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
26.92Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
26.92Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
26.92Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
26.92Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
26.92Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
26.92Single9BLWCagrilintide backbone (non-acylated)9BLW-CT (AMY1)-Cagrilintide backbone (non-acylated)-Gs/β1/γ2; RAMP1
26.92Single9BP3Cagrilintide9BP3-CT (AMY1)-Cagrilintide-Gs/β1/γ2; RAMP1
26.92Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
26.92Consensuscrf2_on_gpOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
26.92Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
26.92Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
26.92Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
26.92Consensuspac1_onOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
26.92Consensuspac1_on_gpOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
26.92Consensuspac_on_gpOrthosteric Ligandpac1_on_gp
26.92Consensusvpac1_on_gpOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
26.67Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
26.67Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
26.67Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
26.67Single7XP6Strychnine7XP6-TAS2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
26.67Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
26.67Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
26.67Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
26.67Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
26.67Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
26.67Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
26.67Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
26.67Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
26.67Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
26.67Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
26.67Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
26.67Single8YN7Immethridine8YN7-H3-Immethridine-Go/β1/γ2
26.67Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
26.67Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
26.32Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
26.32Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
26.32Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
26.32Single5D5AS-Carazolol5D5A-β2-S-Carazolol
26.32Single5D5BS-Carazolol5D5B-β2-S-Carazolol
26.32Single5XRAAM115425XRA-CB1-AM11542
26.32Single6J21Aprepitant6J21-NK1-Aprepitant
26.32Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
26.32Single6WGTLSD6WGT-5-HT2A-LSD
26.32Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
26.32Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
26.32Single7FEECP559407FEE-CB1-CP55940-ZCZ011
26.32Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
26.32Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
26.32Single7TUYGSK682753A7TUY-GPR183-GSK682753A
26.32Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
26.32Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
26.32Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
26.32Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
26.32Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
26.32Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
26.32Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
26.32Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
26.32Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
26.32Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
26.32Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
26.32Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
26.32Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
26.32Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
26.32Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
26.32Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
26.32Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
26.32Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
26.32Single8Y73Peptide8Y73-μ-Peptide-MPAM-15-Gi1/β1/γ2
26.32Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
26.32Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
26.32Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
26.32Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
26.32Single9JMCDS-3801b9JMC-Motilin-DS-3801b-chim(Gs-CtGq)/β1/γ2
26.32Single9UY3Anamorelin9UY3-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
26.32Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
26.32Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
26.32Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
26.32Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
26.32Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
26.32Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
26.32Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
26.32Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
26.32Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
26.32Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
26.09Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
26.09Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
26.09Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
26.09Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
26.09Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
26.09Single9IK8SST analogue9IK8-SST1-SST analogue-Gi1/β1/γ2
26.09Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
26.09Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
26.09Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
26.09Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
26.09Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
25.93Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
25.93Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
25.93Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
25.93Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
25.93Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
25.93Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
25.93Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
25.81Consensusclass-a_class-b1_cons_on_gpOrthosteric Ligandclass-a_on_gp class-b1_on_gp
25.00Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
25.00Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
25.00Single3D4STimolol3D4S-β2-Timolol
25.00Single3OE0CVX153OE0-CXCR4-CVX15
25.00Single3PWHZM-2413853PWH-A2A-ZM-241385
25.00Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
25.00Single4N4WSANT-14N4W-SMO-SANT-1
25.00Single4XEENeurotensin4XEE-NTS1-Neurotensin
25.00Single4XESNeurotensin4XES-NTS1-Neurotensin
25.00Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
25.00Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
25.00Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
25.00Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
25.00Single6AKXA4R6AKX-CCR5-A4R
25.00Single6AKYMaraviroc6AKY-CCR5-Maraviroc
25.00Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
25.00Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
25.00Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
25.00Single6KQICP559406KQI-CB1-CP55940-Org27569
25.00Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
25.00Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
25.00Single6MXTSalmeterol6MXT-β2-Salmeterol
25.00Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
25.00Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
25.00Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
25.00Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
25.00Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
25.00Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
25.00Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
25.00Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
25.00Single6YVRNTS8-136YVR-NTS1-NTS8-13
25.00Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
25.00Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
25.00Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
25.00Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
25.00Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
25.00Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
25.00Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
25.00Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
25.00Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
25.00Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
25.00Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
25.00Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
25.00Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
25.00Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
25.00Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
25.00Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
25.00Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
25.00Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
25.00Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
25.00Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
25.00Single7XRRLemborexant7XRR-OX2-Lemborexant
25.00Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
25.00Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
25.00Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
25.00Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
25.00Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
25.00Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
25.00Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
25.00Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
25.00Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
25.00Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
25.00Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
25.00Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
25.00Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
25.00Single8JJ8Formoterol8JJ8-β2-Formoterol
25.00Single8JJLOlodaterol8JJL-β2-Olodaterol
25.00Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
25.00Single8JWY2-1188JWY-A2A-2-118
25.00Single8JWZAB9288JWZ-A2A-AB928-Na
25.00Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
25.00Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
25.00Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
25.00Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
25.00Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
25.00Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
25.00Single8XJNCloprosetnol8XJN-TXA2-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
25.00Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
25.00Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ2
25.00Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
25.00Single9EBHAdenosine9EBH-A3A-Adenosine-Gi1/β1/γ2
25.00Single9EEAAdenosine9EEA-A2A-Adenosine-Gs/β1/γ2
25.00Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
25.00Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
25.00Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
25.00Single9K6LSA09K6L-TAS2R16-SA0-Gi2/β1/γ2
25.00Single9M4QDoxazosin9M4Q-Alpha1A-Doxazosin
25.00Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
25.00Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
25.00Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
25.00Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
25.00Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
25.00Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
25.00Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
25.00Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
25.00Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
25.00Consensusclass-b1_class-b2_cons_onOrthosteric Ligandclass-b1_on class-b2_on
25.00Consensusclass-b1_class-b2_cons_on_gpOrthosteric Ligandclass-b1_on_gp class-b2_on_gp
25.00Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
25.00Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
25.00Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
25.00Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
25.00Consensusglucagon_on_gpOrthosteric Ligandglp_on_gp gluc_on_gp secretin_on_gp gip_on_gp
25.00Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
25.00Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
25.00Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
25.00Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
25.00Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
25.00Consensuslpa_offOrthosteric Ligandlpa1_off
25.00Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
25.00Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
25.00Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
25.00Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
25.00Consensusorexin_onOrthosteric Ligandox2_on
25.00Consensuspth_onOrthosteric Ligandpth1_on pth2_on
25.00Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
25.00Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
25.00Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
25.00Consensusvip-pacap_onOrthosteric Ligandvpac_on pac_on
25.00Consensusvip-pacap_on_gpOrthosteric Ligandvpac_on_gp pac_on_gp
25.00Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
25.00Consensusvpac2_on_gpOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
24.14Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
24.14Consensuscrf1_onOrthosteric Ligand6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF1-Corticoliberin-Gs/β1/γ2
24.14Consensusgip_onOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
24.14Consensusgip_on_gpOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
24.00Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
24.00Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
24.00Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
24.00Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
24.00Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
24.00Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
24.00Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
24.00Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
24.00Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
24.00Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
24.00Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ2
24.00Single9BUDCagrilintide9BUD-CT-Cagrilintide-Gs/β1/γ2
24.00Single9EBOGLP-1 (ACPC18)9EBO-GLP-1-GLP-1 (ACPC18)-Gs/β1/γ2
24.00Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
24.00Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
24.00Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
24.00Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
24.00Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
24.00Consensusvasop-oxy_onOrthosteric Ligandv2_on
24.00Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
23.81Single4BUONeurotensin4BUO-NTS1-Neurotensin
23.81Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
23.81Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
23.81Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
23.81Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
23.81Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
23.81Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
23.81Single6H7LDobutamine6H7L-β1-Dobutamine
23.81Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
23.81Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
23.81Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
23.81Single7UM4AS26747237UM4-5-HT5A-AS2674723
23.81Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
23.81Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
23.81Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
23.81Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
23.81Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-SBI-553-chim(NtGi1-Go)/β1/γ2
23.81Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
23.81Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
23.81Single8XJOU466198XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
23.81Single8ZPLHF511168ZPL-CXCR4-HF51116
23.81Single8ZWGJR14a8ZWG-C3aB-JR14a-Gi1/β1/γ2
23.81Single9C0KExendin-49C0K-GLP-1-Exendin-4-Gs/β1/γ2
23.81Single9GG5U466199GG5-TXA2-U46619-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.81Single9M1HProstaglandin E29M1H-EP1-Prostaglandin E2-chim(NtGi1-Gs-CtGq)/β1/γ2
23.81Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
23.81Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
23.81Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
23.81Consensusfp-alpha_onOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
23.81Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
23.81Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
23.81Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
23.81Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
23.81Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
23.81Consensustp_onOrthosteric Ligand8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
23.81Consensustp_on_gpOrthosteric Ligand8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
23.53Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
23.53Single4MBSMaraviroc4MBS-CCR5-Maraviroc
23.53Single6IQLL7458706IQL-D4-L745870
23.53Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
23.53Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
23.53Single6MH8ZM-2413856MH8-A2A-ZM-241385
23.53Single6PS5S-Propranolol6PS5-β2-S-Propranolol
23.53Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
23.53Single6VI4JDTic6VI4-κ-JDTic
23.53Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
23.53Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
23.53Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
23.53Single7AROLUF58337ARO-A2A-LUF5833-Na
23.53Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
23.53Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
23.53Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
23.53Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
23.53Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
23.53Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
23.53Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.53Single7T94Acetylcholine7T94-M2-Acetylcholine-LY2119620-chim(NtGi1-Go)/β1/γ2
23.53Single7T94LY21196207T94-M2-Acetylcholine-LY2119620-chim(NtGi1-Go)/β1/γ2
23.53Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
23.53Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
23.53Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
23.53Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
23.53Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.53Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.53Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
23.53Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
23.53Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
23.53Single8K2WAMG4878K2W-CXCR3-AMG487
23.53Single8K9LDamgo8K9L-μ-Damgo-BMS-986122-Gi3/β1/γ1
23.53Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
23.53Single8RLNLUF58348RLN-A2A-LUF5834
23.53Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
23.53Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
23.53Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.53Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.53Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.53Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.53Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
23.53Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
23.53Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
23.53Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
23.53Single8Y6YGLPG09748Y6Y-FFA2-GLPG0974
23.53Single8ZPNAMD31008ZPN-CXCR4-AMD3100
23.53Single9AS3LSD9AS3-5-HT2A-LSD
23.53Single9AS4LSD9AS4-5-HT2A-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
23.53Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
23.53Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
23.53Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
23.53Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
23.53Single9JH3CMF-0199JH3-Apelin-CMF-019-Gi1/β1/γ2
23.53Single9KPDSA09KPD-TAS2R16-SA0-chim(Gs-CtGt3)/β1/γ2
23.53Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
23.53Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
23.53Consensusalpha1_onOrthosteric Ligandalpha1a_on
23.53Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
23.53Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
23.53Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
23.53Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
23.53Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
23.53Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
23.53Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
23.53Consensuspth2_on_gpOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
23.33Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
23.33Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
23.08Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
23.08Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
23.08Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
23.08Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
23.08Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
23.08Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
23.08Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
23.08Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
23.08Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
23.08Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
23.08Single8PWNTheophylline8PWN-A2A-Theophylline
23.08Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
23.08Single9JFYhNPSF9JFY-NPFF2-hNPSF-Gi1/β1/γ2
23.08Consensuscalcitonin_onOrthosteric Ligandctlike_on
23.08Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
23.08Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
23.08Consensusvpac_onOrthosteric Ligandvpac1_on vpac2_on
22.86Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
22.73Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
22.73Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
22.73Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
22.73Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
22.73Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.73Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
22.73Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
22.73Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
22.73Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73Single8QJ2pN1628QJ2-MC4-pN162-Gs
22.73Single8X5YAstemizole8X5Y-H1-Astemizole
22.73Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
22.73Single9IPVJR14a9IPV-C3aB-JR14a-Gi1/β1/γ2
22.73Single9IPYJR14a9IPY-C3aB-JR14a
22.73Single9JF4PD1683689JF4-BB1-PD168368
22.73Single9V2NMacimorelin9V2N-Ghrelin-Macimorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
22.58Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
22.58Consensuscrf1_on_gpOrthosteric Ligand6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF1-Corticoliberin-Gs/β1/γ2
22.58Consensuscrf_on_gpOrthosteric Ligandcrf2_on_gp crf1_on_gp
22.58Consensusglp1_on_gpOrthosteric Ligand7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
22.22Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
22.22Single2Y01Dobutamine2Y01-β1-Dobutamine
22.22Single2Y02Carmoterol2Y02-β1-Carmoterol
22.22Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
22.22Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
22.22Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
22.22Single4EJ4Naltrindole4EJ4-δ-Naltrindole
22.22Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
22.22Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
22.22Single5T04Neurotensin5T04-NTS1-Neurotensin
22.22Single5UENDU1725UEN-A1-DU172
22.22Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
22.22Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
22.22Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
22.22Single6D27CAY104716D27-DP2-CAY10471
22.22Single6IIVDaltroban6IIV-TXA2-Daltroban
22.22Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
22.22Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
22.22Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
22.22Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.22Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
22.22Single7BU7BI1671077BU7-β1-BI167107
22.22Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
22.22Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
22.22Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
22.22Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
22.22Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
22.22Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
22.22Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
22.22Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
22.22Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
22.22Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
22.22Single7SK3CXCL127SK3-ACKR3-CXCL12
22.22Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
22.22Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
22.22Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
22.22Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
22.22Single7WC7Lisuride7WC7-5-HT2A-Lisuride
22.22Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
22.22Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
22.22Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
22.22Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
22.22Single8CU6LJ-45178CU6-A2A-LJ-4517
22.22Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
22.22Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
22.22Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
22.22Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
22.22Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
22.22Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
22.22Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
22.22Single8JXRLSD8JXR-D1-LSD
22.22Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
22.22Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
22.22Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
22.22Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
22.22Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
22.22Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
22.22Single8YN8Proxyfan8YN8-H3-Proxyfan-Go/β1/γ2
22.22Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
22.22Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
22.22Single8ZYYNeurotensin peptide 8-138ZYY-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
22.22Single9AS1DMT9AS1-5-HT2A-DMT
22.22Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
22.22Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
22.22Single9H37A1IR09H37-A2A-A1IR0-Na
22.22Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
22.22Single9JEAAtropine9JEA-M1-Atropine
22.22Single9PLNN-(5-methylnaphthalen-1-yl)pyridin-4-amine9PLN-α2a-N-(5-methylnaphthalen-1-yl)pyridin-4-amine
22.22Single9PLON-(5-methylnaphthalen-1-yl)pyridin-4-amine9PLO-α2a-N-(5-methylnaphthalen-1-yl)pyridin-4-amine-Go/β1/γ2
22.22Single9PQD(6m)-1-methyl-6-(1,2,5,6-tetrahydropyridin-3-yl)-1h-indole9PQD-α2a-(6m)-1-methyl-6-(1,2,5,6-tetrahydropyridin-3-yl)-1h-indole
22.22Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
22.22Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
22.22Consensus5ht5_onOrthosteric Ligand5ht5a_on
22.22Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
22.22Consensusalpha2_onOrthosteric Ligandalpha2b_on
22.22Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
22.22Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
22.22Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
22.22Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
22.22Consensuscalcitonin_on_gpOrthosteric Ligandctlike_on_gp
22.22Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
22.22Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
22.22Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
22.22Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
22.22Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
22.22Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
22.22Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
22.22Consensuspth_on_gpOrthosteric Ligandpth1_on_gp pth2_on_gp
22.22Consensusvpac_on_gpOrthosteric Ligandvpac1_on_gp vpac2_on_gp
21.88Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
21.88Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
21.88Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
21.88Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
21.88Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
21.88Consensusglucagon_onOrthosteric Ligandglp_on gluc_on secretin_on gip_on
21.88Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
21.74Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
21.74Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
21.74Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
21.74Single8IEBA1LYA8IEB-GPR156-A1LYA
21.74Single8IEIA1LYA8IEI-GPR156-A1LYA
21.74Single8IEIA1LYA8IEI-GPR156-A1LYA
21.74Single8IEPA1LYA8IEP-GPR156-A1LYA
21.74Single8IEPA1LYA8IEP-GPR156-A1LYA
21.74Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
21.74Single8KIGSHU91198KIG-MC3-SHU9119-Ca
21.74Single8WKYPG-9348WKY-MC4-PG-934
21.74Single8YWFRetatrutide8YWF-GLP-1-Retatrutide-chim(NtGi1-Gs)/β1/γ2
21.74Single9BUECagrilintide9BUE-CT-Cagrilintide-Gs/β1/γ2
21.74Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
21.74Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
21.74Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
21.74Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
21.43Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
21.43Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
21.43Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
21.43Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
21.43Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
21.43Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
21.43Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
21.43Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
21.43Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
21.43Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
21.43Single8A2OTheophylline8A2O-A2A-Theophylline-Na
21.43Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
21.43Single8IWM2-Phenylethylamine8IWM-TA9-2-Phenylethylamine
21.43Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
21.43Single9CHUNoradrenaline9CHU-β2-Noradrenaline
21.43Single9KDFRES-701-39KDF-ETB-RES-701-3
21.43Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
21.43Consensusglp2_on_gpOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
21.43Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
21.43Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
21.43Consensussensory_onOrthosteric Ligandopsins_on
21.05Single2Y00Dobutamine2Y00-β1-Dobutamine
21.05Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
21.05Single5CGCHTL142425CGC-mGlu5-HTL14242
21.05Single5N2RPSB-365N2R-A2A-PSB-36-Na
21.05Single5N2SPSB365N2S-A1-PSB36
21.05Single5TVNLSD5TVN-5-HT2B-LSD
21.05Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
21.05Single6E67BI1671076E67-β2-BI167107-Gs(CT)
21.05Single6LUQHaloperidol6LUQ-D2-Haloperidol
21.05Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
21.05Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
21.05Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
21.05Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
21.05Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
21.05Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
21.05Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
21.05Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
21.05Single7WC6LSD7WC6-5-HT2A-LSD
21.05Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.05Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
21.05Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.05Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
21.05Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
21.05Single8ZMFA1L108ZMF-5-HT2C-A1L10
21.05Single8ZVZBW245C8ZVZ-DP1-BW245C-Gs/β1/γ2
21.05Single8ZYTNeurotensin peptide 8-138ZYT-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
21.05Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
21.05Single9DYDAsenapine9DYD-5-HT1A-Asenapine-Go/β1/γ2
21.05Single9DYFAsenapine9DYF-5-HT1A-Asenapine-Gi1/β1/γ2
21.05Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
21.05Single9F34FOB02-04A9F34-D3-FOB02-04A-Go/β1/γ2
21.05Single9GE2ML1849GE2-GPR55-ML184-chim(NtGi1-G13)/β1/γ2
21.05Single9HAPTolvaptan9HAP-V2-Tolvaptan
21.05Single9K07DSO-5a9K07-BB3-DSO-5a-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.05Single9KPFSA09KPF-TAS2R16-SA0-Gi1/β1/γ2
21.05Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
21.05Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
21.05Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
21.05Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
21.05Consensusadenosine_offOrthosteric Liganda1_off a2_off
21.05Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
21.05Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
21.05Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
21.05Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
21.05Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
21.05Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
21.05Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.05Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.05Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
20.83Single6HLOAprepitant6HLO-NK1-Aprepitant
20.83Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
20.83Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
20.83Single7SK5CXCL127SK5-ACKR3-CXCL12
20.83Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
20.83Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Single8IEBA1LYA8IEB-GPR156-A1LYA
20.83Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
20.83Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
20.83Single9IQSMuscarinic toxin 39IQS-M4-Muscarinic toxin 3
20.83Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
20.83Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
20.83Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
20.69Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
20.69Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
20.69Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
20.69Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
20.69Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
20.69Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
20.69Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
20.69Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
20.69Consensusendothelin_onOrthosteric Ligandetb_on eta_on
20.69Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
20.69Consensuspth1_onOrthosteric Ligand6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
20.00Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
20.00Single3P0GBI1671073P0G-β2-BI167107
20.00Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
20.00Single3UZAGTPL92363UZA-A2A-GTPL9236
20.00Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
20.00Single4BV0Neurotensin4BV0-NTS1-Neurotensin
20.00Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
20.00Single4U15Tiotropium4U15-M3-Tiotropium
20.00Single5V54Methiothepin5V54-5-HT1B-Methiothepin
20.00Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
20.00Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
20.00Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
20.00Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
20.00Single6J20Aprepitant6J20-NK1-Aprepitant
20.00Single6ME5Agomelatine6ME5-MT1-Agomelatine
20.00Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
20.00Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
20.00Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
20.00Single6OL9Tiotropium6OL9-M5-Tiotropium
20.00Single6OS1TRV0266OS1-AT1-TRV026
20.00Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
20.00Single6PT2KGCHM076PT2-δ-KGCHM07
20.00Single6W25SHU91196W25-MC4-SHU9119-Ca
20.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
20.00Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
20.00Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
20.00Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
20.00Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
20.00Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
20.00Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
20.00Single7PX4PSB-21137PX4-A2A-PSB-2113
20.00Single7RBTTirzepatide7RBT-GIP-Tirzepatide-LSN3556672-chim(NtGi1-Gs)/β1/γ2
20.00Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
20.00Single7T9NDPPC7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
20.00Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
20.00Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
20.00Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
20.00Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
20.00Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
20.00Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
20.00Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
20.00Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
20.00Single8EA0Iperoxo8EA0-M3-Iperoxo
20.00Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
20.00Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
20.00Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
20.00Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
20.00Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
20.00Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single8IW72-Phenylethylamine8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
20.00Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
20.00Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
20.00Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
20.00Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
20.00Single8W8YGamma-MSH8W8Y-MC3-γ-MSH-Ca-Gs/β1/γ2
20.00Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
20.00Single8XVLZibotentan8XVL-ETA-Zibotentan
20.00Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
20.00Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
20.00Single8YNTSNAP-948478YNT-MCH1-SNAP-94847
20.00Single8ZW0PGD28ZW0-DP1-PGD2-Gs/β1/γ2
20.00Single8ZWFJR14a8ZWF-C3aB-JR14a
20.00Single9B5YLong-Acting PTH9B5Y-PTH1-Long-Acting PTH-chim(NtGi1-Gq)/β1/γ2
20.00Single9BJKNaloxone9BJK-μ-Naloxone-NAM
20.00Single9JHJC18:0 Ceramide9JHJ-FPR2-ALX-C18:0 Ceramide-Gi1/β1/γ2
20.00Single9M1OMorphine-Modulating Neuropeptide B9M1O-NPFF2-Morphine-Modulating Neuropeptide B-Gi1/β1/γ2
20.00Consensus5ht1_offOrthosteric Ligand5ht1b_off
20.00Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
20.00Consensus5ht2_onOrthosteric Ligand5ht2b_on
20.00Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Consensusclass-b1_onOrthosteric Ligandglucagon_on vip-pacap_on pth_on crf_on calcitonin_on
20.00Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
20.00Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
20.00Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
20.00Consensusgi_sensoryOrthosteric Ligandgi_opsins
20.00Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
20.00Consensuslpa_onOrthosteric Ligandlpa1_on
20.00Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
20.00Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
20.00Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
20.00Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
20.00Consensusneurotensin_onOrthosteric Ligandnts1_on
20.00Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
20.00Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
20.00Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
20.00Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
20.00Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
20.00Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
20.00Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
19.35Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
19.35Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
19.35Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
19.35Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
19.35Single9AUCCalcitonin gene-related peptide-19AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
19.35Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
19.35Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
19.35Consensusglp1_onOrthosteric Ligand7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
19.35Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
19.35Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
19.23Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
19.23Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
19.23Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
19.23Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
19.23Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
19.23Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
19.23Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
19.05Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
19.05Single5CXVTiotropium5CXV-M1-Tiotropium
19.05Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
19.05Single6CM4Risperidone6CM4-D2-Risperidone
19.05Single6IIURamatroban6IIU-TXA2-Ramatroban
19.05Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
19.05Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
19.05Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
19.05Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
19.05Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
19.05Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
19.05Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
19.05Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
19.05Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
19.05Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
19.05Single9AU0BW245C9AU0-DP1-BW245C-Gs/β1/γ2
19.05Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
19.05Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
19.05Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
19.05Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
19.05Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
18.75Single3PBLEticlopride3PBL-D3-Eticlopride
18.75Single5L7IVismodegib5L7I-SMO-Vismodegib
18.75Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
18.75Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
18.75Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
18.75Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
18.75Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
18.75Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
18.75Single7SRQLSD7SRQ-5-HT2B-LSD
18.75Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
18.75Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
18.75Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
18.75Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
18.75Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
18.75Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
18.75Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.75Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
18.75Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
18.75Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
18.75Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab
18.75Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
18.75Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.75Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
18.75Single9AS2DMT9AS2-5-HT2A-DMT-chim(NtGi1-Gs-CtGq)/β1/γ2
18.75Single9B9Y7DY9B9Y-CB1-7DY
18.75Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
18.75Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
18.75Single9IXJHistamine9IXJ-H2-Histamine-Gs/β1/γ2
18.75Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
18.75Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
18.75Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
18.75Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
18.75Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
18.75Consensuspth1_on_gpOrthosteric Ligand6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
18.52Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
18.52Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
18.52Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.52Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
18.52Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
18.18Single5CGDHTL142425CGD-mGlu5-HTL14242
18.18Single6K1QIRL25006K1Q-ETB-IRL2500
18.18Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
18.18Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
18.18Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
18.18Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
18.18Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.18Single8JPFNeurotensin8JPF-NTS1-Neurotensin-SBI-553
18.18Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
18.18Single8XVJMacitentan8XVJ-ETA-Macitentan
18.18Single9CGJC6-Quino9CGJ-δ-C6-Quino-Gi1/β1/γ2
18.18Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
18.18Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
17.95Consensusclass-b1_on_gpOrthosteric Ligandglucagon_on_gp vip-pacap_on_gp pth_on_gp crf_on_gp calcitonin_on_gp
17.86Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
17.86Single9BLBCagrilintide backbone (non-acylated)9BLB-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
17.86Single9BUBCagrilintide9BUB-CT-Cagrilintide-Gs/β1/γ2
17.86Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
17.65Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
17.65Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
17.65Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
17.65Single4BWBNeurotensin4BWB-NTS1-Neurotensin
17.65Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
17.65Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
17.65Single5U09Taranabant5U09-CB1-Taranabant
17.65Single6DS0Ly2660976DS0-5-HT2B-Ly266097
17.65Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
17.65Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
17.65Single6ME2Ramelteon6ME2-MT1-Ramelteon
17.65Single6ME9Ramelteon6ME9-MT2-Ramelteon
17.65Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
17.65Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
17.65Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
17.65Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
17.65Single7F8YDevazepide7F8Y-CCKA-Devazepide
17.65Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
17.65Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
17.65Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
17.65Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
17.65Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.65Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
17.65Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
17.65Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.65Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
17.65Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
17.65Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
17.65Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.65Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.65Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
17.65Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
17.65Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
17.65Single8U4PAMD31008U4P-CXCR4-AMD3100-Gi1/β1/γ2
17.65Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
17.65Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
17.65Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
17.65Single9H2XA1IR19H2X-A2A-A1IR1-Na
17.65Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
17.65Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.65Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
17.65Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
17.65Consensusgluc_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
17.65Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
17.65Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
17.65Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
17.39Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
17.39Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
17.39Single6PT3DPI-2876PT3-δ-DPI-287
17.39Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
17.39Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
17.39Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
17.39Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
17.39Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
17.39Single9CGKC5-Quino9CGK-δ-C5-Quino-Gi1/β1/γ2
17.24Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
17.24Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
17.24Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
17.24Single8W8WAlpha-MSH8W8W-MC3-α-MSH-Ca-Gs/β1/γ2
17.24Single8W8XBeta-MSH8W8X-MC3-β-MSH-Ca-Gs/β1/γ2
17.24Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
17.14Consensusgluc_on_gpOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
17.14Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
17.14Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
16.67Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
16.67Single3REYXAC3REY-A2A-XAC
16.67Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
16.67Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
16.67Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
16.67Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
16.67Single5IU7Q274563465IU7-A2A-Q27456346-Na
16.67Single5IUBQ274563445IUB-A2A-Q27456344-Na
16.67Single5JTBZM-2413855JTB-A2A-ZM-241385
16.67Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
16.67Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
16.67Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
16.67Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
16.67Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
16.67Single6A94Zotepine6A94-5-HT2A-Zotepine
16.67Single6AQFZM-2413856AQF-A2A-ZM-241385
16.67Single6TPKRetosiban6TPK-OT-Retosiban
16.67Single6TPNHTL66416TPN-OX2-HTL6641
16.67Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
16.67Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
16.67Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
16.67Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
16.67Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
16.67Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
16.67Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
16.67Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
16.67Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
16.67Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
16.67Single7T32ZM-2413857T32-A2A-ZM-241385
16.67Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
16.67Single7VODCariprazine7VOD-5-HT2A-Cariprazine
16.67Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
16.67Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
16.67Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
16.67Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
16.67Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
16.67Single8IY6Endothelin-18IY6-ETB-Endothelin-1
16.67Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
16.67Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
16.67Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
16.67Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
16.67Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
16.67Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
16.67Single8XWNCXCL88XWN-CXCR2-CXCL8
16.67Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
16.67Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
16.67Single8YRGFospropofol8YRG-MRGPRX4-Fospropofol-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
16.67Single9BA0A1AKN9BA0-CB1-A1AKN
16.67Single9BQ3Cagrilintide9BQ3-CT (AMY2)-Cagrilintide-Gs/β1/γ2; RAMP2
16.67Single9BTWCagrilintide9BTW-CT (AMY3)-Cagrilintide-Gs/β1/γ2; RAMP3
16.67Single9LRDHistamine9LRD-H1-Histamine-Gi1/β1/γ2
16.67Consensusa2_offOrthosteric Liganda2a_off
16.67Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
16.67Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
16.67Consensusctlike_on_gpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
16.67Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
16.67Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
16.67Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
16.67Consensusopsins_offOrthosteric Ligandrhodopsin_off
16.67Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
16.67Consensussensory_offOrthosteric Ligandopsins_off
16.67Consensusvasop-oxy_offOrthosteric Ligandot_off
16.13Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
16.13Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
16.00Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
16.00Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
16.00Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
16.00Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
16.00Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
16.00Single9IQRMuscarinic toxin 39IQR-α2a-Muscarinic toxin 3
16.00Single9J0FNADH9J0F-P2Y14-NADH-Gi1/β1/γ2
16.00Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
16.00Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
15.79Single3EMLZM-2413853EML-A2A-ZM-241385
15.79Single4DAJTiotropium4DAJ-M3-Tiotropium
15.79Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
15.79Single4MQSIperoxo4MQS-M2-Iperoxo
15.79Single4QIMANTA XV4QIM-SMO-ANTA XV
15.79Single4U14Tiotropium4U14-M3-Tiotropium
15.79Single5DSGTiotropium5DSG-M4-Tiotropium
15.79Single5IU8Q274563475IU8-A2A-Q27456347-Na
15.79Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
15.79Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
15.79Single5UIGCmpd-15UIG-A2A-Cmpd-1
15.79Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
15.79Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
15.79Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
15.79Single6S0LZM-2413856S0L-A2A-ZM-241385
15.79Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
15.79Single7F83PF-051904577F83-Ghrelin-PF-05190457
15.79Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
15.79Single7PYRPSB-21157PYR-A2A-PSB-2115
15.79Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
15.79Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
15.79Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
15.79Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.79Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
15.79Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
15.79Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
15.79Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
15.79Single8X63Mepyramine8X63-H1-Mepyramine
15.79Single8X64Desloratadine8X64-H1-Desloratadine
15.79Single9IVGGLP-1 (Truncated)9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
15.79Single9IYAONO-97105319IYA-GPR55-ONO-9710531
15.79Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
15.79Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
15.79Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
15.79Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
15.79Consensuscck_offOrthosteric Ligandccka_off
15.79Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
15.79Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
15.79Consensushistamine_offOrthosteric Ligandh1_off
15.79Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
15.79Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
15.79Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
15.62Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
15.38Single5MZPCaffeine5MZP-A2A-Caffeine-Na
15.38Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.38Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
15.38Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
15.38Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
15.38Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
15.00Single4JKVTaladegib4JKV-SMO-Taladegib
15.00Single5IUAQ274563485IUA-A2A-Q27456348-Na
15.00Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
15.00Single5XPRBosentan5XPR-ETB-Bosentan
15.00Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
15.00Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
15.00Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
15.00Single6S0QZM-2413856S0Q-A2A-ZM-241385
15.00Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
15.00Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
15.00Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
15.00Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
15.00Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.00Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
15.00Single8GNEKW-63568GNE-A2A-KW-6356-Na
15.00Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
15.00Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
15.00Single8QOTNanobody-E8QOT-μ-Nanobody-E
15.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
15.00Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
15.00Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
15.00Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
15.00Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
15.00Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
15.00Single9ARYSerotonin9ARY-5-HT2A-Serotonin-chim(NtGi1-Gs-CtGq)/β1/γ2
15.00Single9B9ZA1AKO9B9Z-CB1-A1AKO
15.00Single9HC04YI9HC0-mGlu5-4YI
15.00Consensusadgrg2_onOrthosteric Ligand7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
15.00Consensusadgrg2_on_gpOrthosteric Ligand7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
15.00Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
15.00Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
15.00Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
15.00Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
14.81Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
14.81Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
14.81Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
14.81Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
14.81Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
14.71Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
14.71Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
14.71Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
14.63Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
14.29Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
14.29Single3PXOAll-trans-Retinal3PXO-Rhodopsin-All-trans-Retinal
14.29Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
14.29Single5DYSAll-trans-Retinal5DYS-Rhodopsin-All-trans-Retinal
14.29Single5TZRMK86665TZR-FFA1-MK8666
14.29Single5V56TC1145V56-SMO-TC114
14.29Single5V57TC1145V57-SMO-TC114
14.29Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
14.29Single6E59L-7607356E59-NK1-L-760735
14.29Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
14.29Single7F1TMIP-1a7F1T-CCR5-MIP-1a
14.29Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
14.29Single7P2L4YI7P2L-mGlu5-4YI
14.29Single7R0CAVP7R0C-V2-AVP-Arrestin2
14.29Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
14.29Single7V68LY21196207V68-M4-Iperoxo-LY2119620-Gi1/β1/γ2
14.29Single7WC4Serotonin7WC4-5-HT2A-Serotonin
14.29Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
14.29Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
14.29Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
14.29Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
14.29Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29Single8GDBPGE28GDB-EP4-PGE2-Gs/β1/γ2
14.29Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
14.29Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
14.29Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
14.29Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
14.29Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
14.29Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
14.29Single9AS9RS130-1809AS9-5-HT2A-RS130-180
14.29Single9ASARS130-1809ASA-5-HT2A-RS130-180-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
14.29Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
14.29Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
14.29Consensustachykinin_offOrthosteric Ligandnk1_off
13.64Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
13.64Single5TZYMK8666; AP85TZY-FFA1-MK8666; AP8
13.64Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
13.64Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
13.64Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
13.64Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
13.64Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.64Single8XQJJN2418XQJ-Apelin-JN241
13.33Single2HPYAll-trans-Retinal2HPY-Rhodopsin-All-trans-Retinal
13.33Single3RFMCaffeine3RFM-A2A-Caffeine
13.33Single6TQ9SB-4081246TQ9-OX1-SB-408124
13.33Single6XBM5LWE6XBM-SMO-5LWE-Gi1/β1/γ2
13.33Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
13.33Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Gi1/β1/γ2
13.33Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
13.33Single8Y02Retinal8Y02-OPN1SW-Retinal-Gi1/β1/γ2
13.33Consensusgs_histamineOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
13.33Consensush2_onOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
13.04Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
13.04Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
13.04Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
13.04Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
13.04Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
13.04Single8T3OTUG-8918T3O-FFA4-TUG-891-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.04Single8XVUCXCL28XVU-CXCR2-CXCL2
13.04Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
13.04Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
13.04Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
13.04Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
12.90Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
12.90Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
12.50Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
12.50Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
12.50Single3PQRAll-trans-Retinal3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
12.50Single6KNMJN241-96KNM-Apelin-JN241-9
12.50Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
12.50Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
12.50Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
12.50Single7WC5Psilocin7WC5-5-HT2A-Psilocin
12.50Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
12.50Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
12.50Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
12.50Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
12.50Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
12.50Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
12.50Single8XQJJN2418XQJ-Apelin-JN241
12.50Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
12.50Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
12.50Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
12.50Consensuskisspeptin_onOrthosteric Ligandkiss1_on
12.00Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
12.00Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
12.00Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
12.00Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
12.00Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
12.00Single9J0IUDP-Glucuronic acid9J0I-P2Y14-UDP-Glucuronic acid-Gi1/β1/γ2
12.00Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
12.00Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
12.00Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
12.00Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
12.00Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
11.76Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
11.76Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
11.76Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
11.76Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
11.76Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
11.76Single4O9RCyclopamine4O9R-SMO-Cyclopamine
11.76Single6HLLCP999946HLL-NK1-CP99994
11.76Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
11.76Single6LI0C176LI0-GPR52-C17
11.76Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
11.76Single6TP4ACT-4622066TP4-OX1-ACT-462206
11.76Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
11.76Single7V68Iperoxo7V68-M4-Iperoxo-LY2119620-Gi1/β1/γ2
11.76Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
11.76Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
11.76Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
11.76Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
11.76Single8HSCFab0468HSC-GPR20-Fab046-Gi1/β1/γ2
11.76Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
11.76Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
11.76Single8YN2Histamine8YN2-H1-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
11.76Single8ZYUNeurotensin peptide 8-138ZYU-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
11.76Single9AS7Psilocin9AS7-5-HT2A-Psilocin
11.76Single9E7RGB889E7R-PAR2-GB88-chim(NtGi1L-Gs-CtGq)/β1/γ2
11.76Single9EPRRetinal9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
11.76Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
11.76Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg4_on
11.76Consensusadgrg_on_gpOrthosteric Ligandadgrg2_on_gp adgrg4_on_gp
11.54Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
11.54Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
11.11Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
11.11Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
11.11Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
11.11Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
11.11Single4QINSAG1.54QIN-SMO-SAG1.5
11.11Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
11.11Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
11.11Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
11.11Single7BR3Elagolix7BR3-GnRH1-Elagolix
11.11Single7F8ULintitript7F8U-CCKA-Lintitript
11.11Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
11.11Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
11.11Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
11.11Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
11.11Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
11.11Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
11.11Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
11.11Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
11.11Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
11.11Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
11.11Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
11.11Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
11.11Single9LRBHistamine9LRB-H1-Histamine-Gs/β1/γ2
11.11Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
11.11Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
11.11Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
11.11Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
10.53Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
10.53Single3RZECidoxepin3RZE-H1-Cidoxepin
10.53Single5UVIZM-2413855UVI-A2A-ZM-241385
10.53Single6FFIMMPEP6FFI-mGlu5-MMPEP
10.53Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
10.53Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
10.53Single7UTZDPPC7UTZ-TSH-TR1402-DPPC-Gs/β1/γ2
10.53Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
10.53Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
10.53Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
10.53Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
10.53Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
10.53Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
10.53Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
10.53Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
10.53Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
10.53Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
10.53Single9ARXSerotonin9ARX-5-HT2A-Serotonin
10.53Consensusgrh_offOrthosteric Ligandgnrh1_off
10.00Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
10.00Single6FFHFenobam6FFH-mGlu5-Fenobam
10.00Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
10.00Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
10.00Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
10.00Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
10.00Single9IMATalquetamab9IMA-GPRC5D-Talquetamab
9.52Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
9.52Single6HLPNetupitant6HLP-NK1-Netupitant
9.52Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
9.52Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
9.52Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
9.52Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
9.52Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
9.52Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
9.52Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
9.52Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
9.52Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
9.09Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
9.09Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
9.09Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
9.09Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single8JD5JNJ-40411813; ADX881788JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
9.09Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
9.09Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
9.09Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Gi1/β1/γ1
9.09Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
9.09Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
9.09Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
9.09Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
8.70Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
8.70Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
8.70Single4PY02MeSATP4PY0-P2Y12-2MeSATP
8.70Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.70Single8JD3JNJ-404118138JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
8.70Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
8.70Single8XWACXCL18XWA-CXCR2-CXCL1
8.70Single8XWMCXCL68XWM-CXCR2-CXCL6
8.70Single8XWSCXCL58XWS-CXCR2-CXCL5
8.70Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
8.70Single8Y6WTUG-13758Y6W-FFA2-TUG-1375-4-CMTB-Gi1/β1/γ2
8.70Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
8.33Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
8.33Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
8.33Single8XWFCXCL38XWF-CXCR2-CXCL3
8.33Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
8.33Consensusclass-b2_onOrthosteric Ligandadgrg_on adgrf_on adgrl_on adgre_on adgrd_on
8.33Consensusclass-b2_on_gpOrthosteric Ligandadgrg_on_gp adgrf_on_gp adgrl_on_gp adgre_on_gp adgrd_on_gp
8.00Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
8.00Single9JH6C20:0 Ceramide9JH6-CysLT2-C20:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
8.00Single9NS9TUG-13759NS9-FFA2-TUG-1375-Compound 187-Gi1/β1/γ2
7.69Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
7.69Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.69Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
7.14Single4A4MAll-trans-Retinal4A4M-Rhodopsin-All-trans-Retinal-Gt(CT)
7.14Single5EN0All-trans-Retinal5EN0-Rhodopsin-All-trans-Retinal-Gt(CT)
6.67Single7XKDBeta-Hydroxyandrosterone7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
6.67Single8HS2Fab0468HS2-GPR20-Fab046
6.67Single8X9S5alpha-DHT8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
6.25Single6OY9All-trans-Retinal6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
6.25Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
6.25Single9IVMLSN33188399IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
6.25Consensusp2y_offOrthosteric Ligandp2y1_off
5.88Single4XNWMRS25004XNW-P2Y1-MRS2500
5.88Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
5.88Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
5.88Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/β1/γ2
5.88Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
5.88Single8J6QCompound 9n8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
5.88Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
5.56Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
5.56Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
5.56Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
5.56Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.56Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
5.56Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
5.56Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
5.56Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/β1/γ2
5.56Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
5.56Single8YKDDehydroepiandrosterone8YKD-ADGRG2-Dehydroepiandrosterone-chim(NtGi1-Gs)/β1/γ2
5.26Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
5.26Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
5.26Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
5.26Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
5.26Single7VVOPTH7VVO-PTH1-PTH-Gs/β1/γ2
5.26Single8T3VDocosa-4,7,10,13,16,19-Hexaenoic acid8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.26Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
5.26Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
5.26Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
5.00Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
5.00Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
5.00Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
5.00Single6ZINSR486926ZIN-NTS1-SR48692
5.00Single7VV6C48/807VV6-MRGPRX2-C48/80
5.00Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
5.00Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.00Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Gi1/β1/γ2
4.76Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
4.76Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
4.76Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
4.76Single8TH3AT118-H Nanobody8TH3-AT1-AT118-H Nanobody
4.76Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
4.55Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
4.55Single6Z4SSR486926Z4S-NTS1-SR48692
4.55Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.55Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
4.55Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
4.35Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
4.35Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35Single9CLWTUG-13759CLW-FFA2-TUG-1375-4-CMTB-chim(NtGi1L-Gs-CtGq)/β1/γ2
4.35Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
4.35Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
4.35Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
4.35Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
4.35Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
4.17Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
4.17Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
4.17Single9CM3TUG-13759CM3-FFA2-TUG-1375-Compound 187-chim(NtGi1L-Gs-CtGq)/β1/γ2
4.17Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
4.17Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
4.00Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
4.00Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
3.85Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
3.85Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
3.85Single9CM7TUG-13759CM7-FFA2-TUG-1375-AZ-1729-Gi1/β1/γ2
3.85Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2

Consensus Members
Id Members
8J6R 8J6R-HCA2-MK6892-Gi1/β1/γ2
8IHI 8IHI-HCA2-Acifran-Gi1/β1/γ2
8IHH 8IHH-HCA2-LUF6283-Gi1/β1/γ2
8I7V 8I7V-HCA2-Acipimox-Gi1/β1/γ2
8JIM 8JIM-HCA2-MMF-Gi1/β1/γ2
8I7W 8I7W-HCA2-GSK256073-Gi1/β1/γ2
Net Summary
Imin 2.55667
Number of Linked Nodes 913
Number of Links 1144
Number of Hubs 205
Number of Links mediated by Hubs 746
Number of Communities 29
Number of Nodes involved in Communities 277
Number of Links involved in Communities 401
Path Summary
Number Of Nodes in MetaPath 130
Number Of Links MetaPath 129
Number of Shortest Paths 2685685
Length Of Smallest Path 3
Average Path Length 37.737
Length of Longest Path 68
Minimum Path Strength 0.371667
Average Path Strength 4.98063
Maximum Path Strength 23.585
Minimum Path Correlation 0.7
Average Path Correlation 0.986438
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.69492
Average % Of Corr. Nodes 34.6774
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 53.7028
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following consensuses:
IdComponents
hca_on_gphca2_on_gp



You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download hca2_on_gp.zip



You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.



You can also  read or  download a guide explaining the meaning of all files and numerical data.