Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
1NT 20.9214714
21x28 7.3075444
31x35 3.885606
41x39 5.398507
51x46 1.8025408
61x53 2.73409
71x60 6.816534
82x41 3.2175406
92x42 5.04507
102x46 4.3125459
112x50 5.61559
122x57 5.73408
132x60 7.2025417
142x63 7.5575415
15E1 8.076514
16E1x50 11.054519
17E1x52 7.568506
183x34 4.4075405
193x37 5.62517
203x51 7.086528
21I2x57 5.82506
224x50 5.7175409
23E2 29.8431013
24E2x52 8.0725414
255x43 11.98415
265x47 5.795468
275x50 3.1325408
285x58 5.368509
295x62 5.268525
30I3 3.99875823
316x34 6.678526
326x43 7.275476
336x45 8.585465
346x48 4.906508
356x49 5.2025465
366x51 6.46616
377x53 5.706559
388x50 4.1075438
398x53 7.37635
40Lig 13.04242110
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
17x35 Lig 10.74527.63NoYes150
2E2 Lig 11.577734.3YesYes130
32x57 7x42 11.30378.21YesNo087
43x36 7x42 10.99297.03NoNo077
53x36 Lig 69.40024.87NoYes170
61x50 2x50 1006.73NoYes099
72x46 2x50 53.59974.07YesYes599
82x46 7x53 54.59553.52YesYes599
93x50 7x53 55.20937.2NoYes099
103x50 5x58 55.52018.23NoYes099
113x47 5x58 90.79585.09NoYes099
123x47 5x54 90.23744.64NoNo098
135x54 6x44 89.97395.02NoNo089
146x44 6x48 82.05535.01NoYes098
153x36 6x48 76.35213.42NoYes078
162x50 7x49 53.46286.73YesNo599
177x49 7x53 54.57713.49NoYes599
186x40 7x53 55.98648.46NoYes089
195x58 6x40 57.37734.84YesNo098
201x50 7x50 80.927811.4NoNo099
211x53 7x55 46.72692.62YesNo096
221x53 7x50 73.68883.53YesNo099
231x53 1x57 20.46053.07YesNo097
241x60 8x53 21.967310.92YesYes345
258x50 8x53 32.04874.13YesYes385
267x55 8x50 39.58545.36NoYes068
271x57 2x44 17.9214.28NoNo075
282x40 I1x50 10.27113NoNo087
292x44 I1x50 12.82635.54NoNo057
302x45 4x50 12.96336.78NoYes099
313x34 4x50 15.34217.02YesYes059
323x34 4x53 19.31982.77YesNo058
333x41 4x53 20.1972.77NoNo058
343x37 3x41 21.95156.19YesNo075
353x37 Lig 24.0514.13YesYes170
362x42 4x45 12.08875.19YesNo075
373x51 5x61 30.5553.63YesNo288
385x61 5x65 31.19252.85NoNo288
395x65 6x34 32.82324.87NoYes286
405x62 6x34 45.478310.02YesYes256
415x62 6x37 49.27955.87YesNo057
425x58 6x37 49.91443.63YesNo097
433x52 I2x57 24.01153.64NoYes056
442x38 I2x57 14.47272.62NoYes076
454x41 4x45 10.49231.59NoNo045
465x51 6x44 11.34063.22NoNo069
471x46 1x50 17.9211.7YesNo089
481x45 1x46 10.27111.84NoYes058
493x51 3x52 25.0313.52YesNo085
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
E2NT74.911YesYes3411
NTNT171YesYes4411
LigNT16.751YesYes0401
7x24NT7.281NoYes7421
7x31NT6.311NoYes4411
E1NT7.21YesYes4411
1x32E14.130NoYes4421
1x351x396.040YesYes6722
1x357x355.080YesNo6521
1x397x386.040YesNo7621
2x562x604.850NoYes7721
2x602x633.861YesYes7511
2x603x283.891YesNo7612
2x60Lig16.211YesYes7010
2x63E110.921YesYes5411
2x63E1x5010.611YesYes5912
2x63Lig4.841YesYes5010
2x64E17.490NoYes5421
E1Lig10.641YesYes4010
E1x49E25.011NoYes5321
E1x50E2x5015.671YesNo9922
3x22E212.721NoYes3321
3x327x423.791NoNo6712
3x32Lig3.931NoYes6010
3x334x576.521NoNo4712
3x334x613.421NoNo4412
3x33Lig5.281NoYes4010
3x366x483.421NoYes7812
3x367x427.031NoNo7712
3x36Lig4.871NoYes7010
3x373x416.191YesNo7512
3x374x568.011YesNo7512
3x375x424.991YesNo7312
3x375x434.781YesYes7511
3x37Lig4.131YesYes7010
4x65E2x5217.10NoYes5421
E2E265.491YesYes3311
E2E2x505.121YesNo3912
E2Lig34.31YesYes3010
E2x51Lig4.950NoYes5010
E2E2x524.131YesYes3411
5x39E2x524.870NoYes5421
E2x52Lig6.191YesYes4010
5x36E213.081NoYes3321
6x62E218.181NoYes3321
5x436x517.861YesYes5611
5x436x5510.511YesNo5612
5x43Lig24.771YesYes5010
6x516x556.851YesNo6612
6x517x343.941YesNo6411
6x517x378.211YesNo6712
6x517x383.981YesNo6611
6x51Lig7.921YesYes6010
6x58Lig14.050NoYes4010
6x61E35.891NoNo2112
6x617x304.611NoNo2412
6x61Lig5.011NoYes2010
7x31Lig22.071NoYes4010
7x34Lig13.981NoYes4010
7x35Lig7.631NoYes5010
7x38Lig6.411NoYes6010

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
95.00Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
95.00Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
95.00Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
95.00Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
85.00Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
73.68Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
69.57Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
65.00Single6OS2TRV0266OS2-AT1-TRV026
64.00Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
64.00Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
64.00Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
63.64Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
63.64Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
63.64Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
63.64Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
62.50Single6JODAngiotensin II6JOD-AT2-Angiotensin II
62.50Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
62.50Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
62.50Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
61.90Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
61.54Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
61.54Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
61.54Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
60.87Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
60.00Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
60.00Single6OS1TRV0266OS1-AT1-TRV026
60.00Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
59.26Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
59.26Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
59.26Consensusbradykinin_onOrthosteric Ligandbk2_on
59.26Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
59.26Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
58.33Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
57.69Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
57.14Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
56.52Single4IARErgotamine4IAR-5-HT1B-Ergotamine
56.52Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
56.52Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
56.52Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
56.00Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
55.56Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
55.00Single6D26Fevipiprant6D26-DP2-Fevipiprant
55.00Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
55.00Consensusdp_offOrthosteric Liganddp2_off
54.55Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
54.55Consensuschemerin_onOrthosteric Ligandcml1_on
54.55Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
54.17Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
54.17Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
54.17Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
53.85Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
53.85Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
53.85Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
53.85Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
53.85Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
53.57Single6IGLIRL16206IGL-ETB-IRL1620
52.63Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
52.17Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
52.00Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
52.00Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
51.85Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
51.85Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
51.72Single5GLHEndothelin-15GLH-ETB-Endothelin-1
51.72Single6IGKEndothelin-36IGK-ETB-Endothelin-3
51.72Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
50.00Single6D27CAY104716D27-DP2-CAY10471
50.00Single6MXTSalmeterol6MXT-β2-Salmeterol
50.00Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
50.00Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
50.00Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
50.00Single8JJLOlodaterol8JJL-β2-Olodaterol
50.00Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
50.00Single8WDTphotoNECA8WDT-A2A-photoNECA
50.00Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
50.00Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
50.00Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
50.00Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
50.00Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
50.00Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
50.00Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
50.00Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
50.00Consensuslpl_onOrthosteric Ligands1p_on lpa_on
50.00Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
48.39Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
48.28Single8IY6Endothelin-18IY6-ETB-Endothelin-1
48.28Consensusendothelin_onOrthosteric Ligandetb_on eta_on
48.15Single8ZRTET-18ZRT-ETB-ET-1
48.15Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
48.15Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
48.00Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
48.00Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
48.00Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
48.00Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
48.00Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
48.00Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
48.00Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
48.00Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
48.00Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
48.00Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
47.83Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
47.83Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
47.83Consensusprostanoid_offOrthosteric Ligandep_off dp_off
47.62Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
47.62Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
47.62Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
47.62Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
46.67Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
46.43Single4XT3Fractalkine4XT3-US28-Fractalkine
46.15Single5WF5UK-4320975WF5-A2A-UK-432097
46.15Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
46.15Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
46.15Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
46.15Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
46.15Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
46.15Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
46.15Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
46.15Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
45.83Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
45.83Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
45.83Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
45.83Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
45.83Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
45.83Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
45.83Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
45.83Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
45.45Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
45.45Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
45.45Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
45.45Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
45.45Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
45.45Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
45.45Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
45.16Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
45.00Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
45.00Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
45.00Single7UL3Famotidine7UL3-H2-Famotidine
44.83Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
44.83Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
44.83Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
44.83Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
44.83Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
44.83Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
44.44Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
44.44Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
44.44Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
44.44Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
44.44Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
44.44Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
44.00Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
44.00Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
44.00Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
44.00Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
44.00Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
44.00Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
43.48Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
43.48Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
43.48Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
43.48Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
43.48Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
43.48Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
43.48Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
43.48Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
43.48Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
43.48Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
43.48Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
43.48Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
43.48Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
43.48Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
43.48Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
43.48Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
43.48Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
43.48Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
43.48Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
43.48Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
43.48Consensuslpa_offOrthosteric Ligandlpa1_off
43.48Consensuslpl_offOrthosteric Ligands1p_off lpa_off
43.33Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
43.33Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
42.86Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
42.86Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
42.86Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
42.86Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
42.86Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
42.86Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
42.86Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
42.86Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
42.86Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
42.86Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
42.86Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
42.86Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
42.86Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
42.86Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
42.86Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
42.86Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
42.86Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
42.86Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
42.86Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
42.86Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
42.86Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
42.31Single3QAKUK-4320973QAK-A2A-UK-432097
42.31Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
42.31Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
42.31Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
42.31Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
42.31Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
42.31Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
42.31Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
42.31Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
42.11Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
42.11Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
41.94Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
41.94Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
41.94Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
41.94Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
41.67Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
41.67Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
41.67Single6IBLArformoterol6IBL-β1-Arformoterol
41.67Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
41.67Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
41.67Single7EZCUKA7EZC-A2A-UKA
41.67Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
41.67Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
41.67Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
41.67Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
41.67Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
41.67Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
41.67Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
41.67Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
41.67Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(CtGi1-G13)/β1/γ2
41.67Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
41.38Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
41.38Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
41.38Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
41.38Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
41.38Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
41.38Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
40.91Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
40.91Single5C1MBU725C1M-μ-BU72
40.91Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
40.91Single7C61Ergotamine7C61-5-HT1B-Ergotamine
40.91Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
40.91Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
40.91Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
40.91Single8TF5Oleic acid8TF5-GPR6-Oleic acid
40.91Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
40.91Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
40.91Consensusa3_on_gpOrthosteric Liganda3a_on_gp
40.91Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
40.91Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
40.91Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
40.91Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
40.91Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
40.74Single3OE0CVX153OE0-CXCR4-CVX15
40.74Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
40.74Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
40.74Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
40.74Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
40.74Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
40.74Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
40.74Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
40.74Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
40.62Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
40.62Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
40.00Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
40.00Single5WF6UK-4320975WF6-A2A-UK-432097
40.00Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
40.00Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
40.00Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
40.00Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
40.00Single7SK9CCX6627SK9-ACKR3-CCX662
40.00Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
40.00Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
40.00Single7XN9L-054,5227XN9-SST2-L-054,522
40.00Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
40.00Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
40.00Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
40.00Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
40.00Single8GNGIstradefylline8GNG-A2A-Istradefylline
40.00Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
40.00Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
40.00Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
40.00Single8QJ2pN1628QJ2-MC4-pN162-Gs
40.00Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
40.00Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
40.00Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
40.00Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
40.00Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
40.00Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
40.00Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
40.00Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
39.39Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
39.29Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
39.29Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
39.29Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
39.29Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
39.29Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
39.29Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
39.29Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
39.29Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
39.29Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
39.29Consensusvasop-oxy_onOrthosteric Ligandv2_on
39.29Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
39.13Single3P0GBI1671073P0G-β2-BI167107
39.13Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
39.13Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
39.13Single7F1TMIP-1a7F1T-CCR5-MIP-1a
39.13Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
39.13Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
39.13Single7TUYGSK682753A7TUY-GPR183-GSK682753A
39.13Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
39.13Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
39.13Single8E0GBU728E0G-μ-BU72
39.13Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
39.13Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
39.13Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
39.13Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
39.13Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
39.13Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
39.13Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
39.13Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
39.13Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
39.13Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
39.13Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
39.13Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
39.13Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
39.13Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
38.46Single4XT1Fractalkine4XT1-US28-Fractalkine
38.46Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
38.46Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
38.46Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
38.46Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
38.46Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
38.46Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
38.46Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
38.46Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
38.46Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
38.46Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
38.46Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
38.46Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
38.24Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
38.10Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
38.10Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
38.10Single7AROLUF58337ARO-A2A-LUF5833-Na
38.10Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
38.10Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
38.10Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
38.10Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
38.10Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
38.10Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
38.10Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
38.10Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
38.10Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
38.10Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
38.10Single8ZPMAMD0708ZPM-CXCR4-AMD070-Cholesterol
38.10Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
38.10Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
37.93Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
37.93Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
37.93Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
37.93Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
37.50Single4RWADIPP-NH24RWA-δ-DIPP-NH2
37.50Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
37.50Single6A93Risperidone6A93-5-HT2A-Risperidone
37.50Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
37.50Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
37.50Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
37.50Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
37.50Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
37.50Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
37.50Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
37.50Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
37.50Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
37.50Single8JJ8Formoterol8JJ8-β2-Formoterol
37.50Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
37.50Single8ZPLHF511168ZPL-CXCR4-HF51116-Cholesterol
37.50Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
37.50Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
37.50Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
37.50Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
37.50Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
37.50Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
37.50Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
37.50Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
37.50Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
37.50Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
37.50Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
37.50Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
37.50Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
37.50Consensusorexin_onOrthosteric Ligandox2_on
37.50Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
37.50Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
37.04Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
37.04Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
37.04Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
37.04Single7SK5CXCL127SK5-ACKR3-CXCL12
37.04Single7XNACYN1548067XNA-SST2-CYN154806
37.04Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
37.04Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
37.04Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
37.04Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
37.04Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
36.84Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
36.67Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
36.67Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
36.67Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
36.67Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
36.67Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
36.67Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
36.36Single4QKX35V4QKX-β2-35V
36.36Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
36.36Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
36.36Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
36.36Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
36.36Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
36.36Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
36.36Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
36.36Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
36.36Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
36.36Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
36.36Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
36.36Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
36.36Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
36.36Single8K5DGSK2560738K5D-HCA2-GSK256073
36.36Single8PJKST1718PJK-5-HT1A-ST171-t7m-Gi1/β1/γ1
36.36Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
36.36Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
36.36Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
36.36Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
36.36Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
36.36Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
36.36Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
36.36Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
36.36Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
36.36Single9CHXS-Carazolol9CHX-β2-S-Carazolol
36.36Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
36.36Consensus5ht5_onOrthosteric Ligand5ht5a_on
36.36Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
36.36Consensusa3_onOrthosteric Liganda3a_on
36.36Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
36.36Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
36.36Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
36.36Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
36.36Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
36.36Consensushca_on_gpOrthosteric Ligandhca2_on_gp
36.36Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
36.36Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
36.11Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
36.11Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
36.00Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
36.00Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
36.00Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
36.00Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
36.00Single6H7LDobutamine6H7L-β1-Dobutamine
36.00Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
36.00Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
36.00Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
36.00Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
36.00Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
36.00Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
36.00Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
36.00Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
36.00Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
36.00Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
36.00Consensuscck_onOrthosteric Ligandccka_on cckb_on
36.00Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
36.00Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
36.00Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
35.71Single6PT2KGCHM076PT2-δ-KGCHM07
35.71Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
35.71Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
35.71Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
35.71Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
35.71Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
35.71Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
35.71Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
35.71Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
35.48Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
35.00Single3OE9IT1t3OE9-CXCR4-IT1t
35.00Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
35.00Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
34.78Single2Y00Dobutamine2Y00-β1-Dobutamine
34.78Single5N2RPSB-365N2R-A2A-PSB-36-Na
34.78Single5N2SPSB365N2S-A1-PSB36
34.78Single5WIUNemonapride5WIU-D4-Nemonapride
34.78Single5WIVNemonapride5WIV-D4-Nemonapride-Na
34.78Single6E67BI1671076E67-β2-BI167107-Gs (fused)
34.78Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
34.78Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
34.78Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
34.78Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
34.78Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/β1/γ2
34.78Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
34.78Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
34.78Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
34.78Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
34.78Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
34.78Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
34.78Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
34.78Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
34.78Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
34.78Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
34.78Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
34.78Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
34.78Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
34.78Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
34.78Single8JXSPF-61428JXS-D1-PF-6142
34.78Single8S4DCMF-0198S4D-Apelin-CMF-019
34.78Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
34.78Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
34.78Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
34.78Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
34.78Single9F34FOB02-04A9F34-D3-FOB02-04A-Go1/β1/γ2
34.78Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
34.78Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
34.78Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
34.78Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
34.78Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
34.78Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
34.78Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
34.78Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
34.78Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
34.78Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
34.78Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
34.78Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
34.78Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
34.78Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
34.78Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
34.78Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
34.78Consensustrace-amine_onOrthosteric Ligandta1_on
34.62Single3NY9ICI118-5513NY9-β2-ICI118-551
34.62Single4UG2CGS216804UG2-A2A-CGS21680
34.62Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
34.62Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
34.62Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
34.62Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
34.62Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
34.62Single8X5YAstemizole8X5Y-H1-Astemizole
34.62Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
34.62Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
34.62Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
34.62Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
34.62Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
34.48Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
34.48Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
34.48Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
34.48Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
34.48Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
34.48Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
34.48Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
34.48Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
34.48Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
34.38Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
34.38Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
34.38Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
34.38Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
33.33Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
33.33Single2YDVNECA2YDV-A2A-NECA
33.33Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
33.33Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
33.33Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
33.33Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
33.33Single4UHRCGS216804UHR-A2A-CGS21680
33.33Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
33.33Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
33.33Single5G53NECA5G53-A2A-NECA-Gs
33.33Single6AKXA4R6AKX-CCR5-A4R
33.33Single6AKYMaraviroc6AKY-CCR5-Maraviroc
33.33Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
33.33Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
33.33Single6ME9Ramelteon6ME9-MT2-Ramelteon
33.33Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
33.33Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
33.33Single6WGTLSD6WGT-5-HT2A-LSD
33.33Single7B6WCyclazosin7B6W-α1b-Cyclazosin
33.33Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
33.33Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
33.33Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
33.33Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
33.33Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
33.33Single7F8XNN90567F8X-CCKA-NN9056
33.33Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
33.33Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
33.33Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
33.33Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
33.33Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
33.33Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
33.33Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
33.33Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
33.33Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
33.33Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
33.33Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
33.33Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
33.33Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
33.33Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
33.33Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
33.33Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
33.33Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
33.33Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
33.33Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
33.33Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
33.33Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
33.33Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
33.33Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
33.33Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
33.33Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
33.33Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
33.33Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
33.33Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
33.33Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
33.33Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
33.33Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
33.33Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
33.33Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
33.33Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
33.33Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
33.33Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
33.33Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
33.33Single8PKMBefiradol8PKM-5-HT1A-Befiradol-t7m-Gi1/β1/γ1
33.33Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
33.33Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
33.33Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
33.33Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/β1/γ2
33.33Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
33.33Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
33.33Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
33.33Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
33.33Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
33.33Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
33.33Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
33.33Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
33.33Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
33.33Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
33.33Single8XWNCXCL88XWN-CXCR2-CXCL8
33.33Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
33.33Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
33.33Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
33.33Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
33.33Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
33.33Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
33.33Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
33.33Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
33.33Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
33.33Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
33.33Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
33.33Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
33.33Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
33.33Consensusbombesin_onOrthosteric Ligandbb2_on
33.33Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
33.33Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
33.33Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
33.33Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
33.33Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
33.33Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
33.33Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
33.33Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
33.33Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
33.33Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
33.33Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
33.33Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
33.33Consensuslpa_onOrthosteric Ligandlpa1_on
33.33Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
33.33Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
33.33Consensusrelaxin_onOrthosteric Ligandrxfp4_on
33.33Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
33.33Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
33.33Consensussomatostatin_offOrthosteric Ligandsst2_off
32.35Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
32.26Single7SK3CXCL127SK3-ACKR3-CXCL12
32.26Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
32.26Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
32.14Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
32.14Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
32.14Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
32.14Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
32.00Single3D4STimolol3D4S-β2-Timolol
32.00Single4AMIBucindolol4AMI-β1-Bucindolol
32.00Single4LDEBI1671074LDE-β2-BI167107
32.00Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
32.00Single6ZG4HTL00099366ZG4-M1-HTL0009936
32.00Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
32.00Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
32.00Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
32.00Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
32.00Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
32.00Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
32.00Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
32.00Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
32.00Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
32.00Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
32.00Single7YITNalfurafine7YIT-κ-Nalfurafine
32.00Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
32.00Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
32.00Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
32.00Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
32.00Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
32.00Single8JWY2-1188JWY-A2A-2-118
32.00Single8JWZAB9288JWZ-A2A-AB928-Na
32.00Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
32.00Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
32.00Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
32.00Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
32.00Consensusalpha1_offOrthosteric Ligandalpha1a_off
32.00Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
32.00Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
32.00Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
32.00Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
32.00Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
32.00Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
32.00Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
32.00Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
31.82Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
31.82Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
31.82Single4MBSMaraviroc4MBS-CCR5-Maraviroc
31.82Single6KUXRS-799486KUX-α2a-RS-79948
31.82Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
31.82Single6MH8ZM-2413856MH8-A2A-ZM-241385
31.82Single6PS0S-Carazolol6PS0-β2-S-Carazolol
31.82Single6PS4ICI118-5516PS4-β2-ICI118-551
31.82Single6PS5S-Propranolol6PS5-β2-S-Propranolol
31.82Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
31.82Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
31.82Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
31.82Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
31.82Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
31.82Single7T32ZM-2413857T32-A2A-ZM-241385
31.82Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
31.82Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
31.82Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
31.82Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
31.82Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
31.82Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
31.82Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
31.82Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
31.82Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
31.82Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.82Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.82Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
31.82Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
31.82Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
31.82Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
31.82Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
31.82Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
31.82Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
31.82Single8IHKAcifran8IHK-HCA3-Acifran
31.82Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
31.82Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
31.82Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
31.82Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
31.82Single8K5CAcipimox8K5C-HCA2-Acipimox
31.82Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
31.82Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
31.82Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.82Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.82Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
31.82Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
31.82Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
31.82Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
31.82Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
31.82Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
31.82Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
31.82Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
31.82Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
31.82Consensushca_onOrthosteric Ligandhca2_on
31.82Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
31.25Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
31.25Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
31.25Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
31.03Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
31.03Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
31.03Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
31.03Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
31.03Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
31.03Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
31.03Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
31.03Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
30.95Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
30.77Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
30.77Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
30.77Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
30.77Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
30.77Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
30.77Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
30.77Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
30.77Single7UM4AS26747237UM4-5-HT5A-AS2674723
30.77Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
30.77Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
30.77Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
30.77Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
30.77Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
30.77Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
30.77Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
30.77Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
30.77Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
30.77Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
30.77Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
30.77Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
30.77Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
30.77Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
30.77Consensusendothelin_offOrthosteric Ligandetb_off
30.77Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
30.77Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
30.77Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
30.77Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
30.77Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
30.77Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
30.43Single2Y01Dobutamine2Y01-β1-Dobutamine
30.43Single2Y02Carmoterol2Y02-β1-Carmoterol
30.43Single2Y04Salbutamol2Y04-β1-Salbutamol
30.43Single3NY8ICI118-5513NY8-β2-ICI118-551
30.43Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
30.43Single4EJ4Naltrindole4EJ4-δ-Naltrindole
30.43Single4GBRS-Carazolol4GBR-β2-S-Carazolol
30.43Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
30.43Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
30.43Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
30.43Single5UENDU1725UEN-A1-DU172
30.43Single5UIGCmpd-15UIG-A2A-Cmpd-1
30.43Single6DRXLisuride6DRX-5-HT2B-Lisuride
30.43Single6H7MSalbutamol6H7M-β1-Salbutamol
30.43Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
30.43Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
30.43Single6PS1Timolol6PS1-β2-Timolol
30.43Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
30.43Single6TOTLemborexant6TOT-OX1-Lemborexant
30.43Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
30.43Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
30.43Single7BU7BI1671077BU7-β1-BI167107
30.43Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
30.43Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
30.43Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
30.43Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
30.43Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
30.43Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
30.43Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
30.43Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
30.43Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
30.43Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
30.43Single7UL4Alvimopan7UL4-μ-Alvimopan
30.43Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
30.43Single7V3ZCP559407V3Z-CB1-CP55940
30.43Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
30.43Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
30.43Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
30.43Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
30.43Single7WC7Lisuride7WC7-5-HT2A-Lisuride
30.43Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
30.43Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
30.43Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
30.43Single8CU6LJ-45178CU6-A2A-LJ-4517
30.43Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
30.43Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
30.43Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
30.43Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
30.43Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
30.43Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.43Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.43Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.43Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.43Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.43Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.43Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.43Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.43Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.43Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.43Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
30.43Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
30.43Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
30.43Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
30.43Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
30.43Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
30.43Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
30.43Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
30.43Single8JXRLSD8JXR-D1-LSD
30.43Single8T1WCVN4248T1W-GPR6-CVN424
30.43Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
30.43Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
30.43Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.43Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.43Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.43Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.43Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
30.43Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
30.43Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
30.43Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
30.43Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
30.43Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
30.43Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
30.43Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
30.43Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
30.43Consensusblt_onOrthosteric Ligandblt1_on
30.43Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
30.43Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
30.43Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
30.43Consensusdopamine_offOrthosteric Ligandd2_off d3_off
30.43Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
30.43Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
30.43Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
30.43Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
30.43Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
30.43Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
30.43Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
30.43Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
30.43Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
30.43Consensusleukotriene_onOrthosteric Ligandblt_on
30.43Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
30.43Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
30.30Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
30.30Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
30.30Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
30.00Single3OE6IT1t3OE6-CXCR4-IT1t
30.00Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
30.00Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
30.00Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
30.00Single6ME5Agomelatine6ME5-MT1-Agomelatine
30.00Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
30.00Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
30.00Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
30.00Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
30.00Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.00Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
30.00Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
30.00Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
30.00Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ22
30.00Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
29.63Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
29.63Single5ZTYAM102575ZTY-CB2-AM10257
29.63Single6KNMJN241-96KNM-Apelin-JN241-9
29.63Single6PT3DPI-2876PT3-δ-DPI-287
29.63Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
29.63Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
29.63Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
29.63Single8XQJJN2418XQJ-Apelin-JN241
29.63Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
29.63Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
29.63Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
29.41Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
29.17Single2RH1S-Carazolol2RH1-β2-S-Carazolol
29.17Single2Y03Isoprenaline2Y03-β1-Isoprenaline
29.17Single2YCWS-Carazolol2YCW-β1-S-Carazolol
29.17Single5D6LS-Carazolol5D6L-β2-S-Carazolol
29.17Single5IUAQ274563485IUA-A2A-Q27456348-Na
29.17Single5JQHS-Carazolol5JQH-β2-S-Carazolol
29.17Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
29.17Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
29.17Single5TVNLSD5TVN-5-HT2B-LSD
29.17Single5X7DS-Carazolol5X7D-β2-S-Carazolol-PubChem 129318963
29.17Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
29.17Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
29.17Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
29.17Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
29.17Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
29.17Single6S0QZM-2413856S0Q-A2A-ZM-241385
29.17Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
29.17Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
29.17Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
29.17Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
29.17Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
29.17Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
29.17Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
29.17Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
29.17Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
29.17Single8GNEKW-63568GNE-A2A-KW-6356-Na
29.17Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
29.17Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
29.17Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
29.17Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
29.17Single8XYKVUF106618XYK-CXCR3-VUF10661-Go1/β1/γ2
29.17Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
29.17Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
29.17Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
29.17Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
29.17Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
29.17Consensusadenosine_offOrthosteric Liganda1_off a2_off
29.17Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
29.17Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
29.17Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
29.17Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
29.17Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
29.17Consensusamine_offonOrthosteric Ligandamine_off amine_on
29.17Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
29.17Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
29.17Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
29.17Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
29.17Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
29.17Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
29.17Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
29.17Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
29.17Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
29.17Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
29.03Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
29.03Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
29.03Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
29.03Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
29.03Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
28.57Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
28.57Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
28.57Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
28.57Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
28.57Single7SRQLSD7SRQ-5-HT2B-LSD
28.57Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
28.57Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
28.57Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
28.57Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
28.57Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
28.57Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
28.57Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
28.57Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
28.57Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
28.57Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
28.57Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
28.57Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
28.57Single8K5BNiacin8K5B-HCA2-Niacin
28.57Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
28.57Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
28.57Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
28.57Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
28.57Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
28.57Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
28.57Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
28.57Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
28.57Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
28.57Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
28.57Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
28.21Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
28.12Single6FJ3PTH6FJ3-PTH1-PTH
28.12Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
28.12Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
28.12Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
28.12Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
28.00Single4U15Tiotropium4U15-M3-Tiotropium
28.00Single5D5AS-Carazolol5D5A-β2-S-Carazolol
28.00Single5D5BS-Carazolol5D5B-β2-S-Carazolol
28.00Single5V54Methiothepin5V54-5-HT1B-Methiothepin
28.00Single5XR8AM8415XR8-CB1-AM841
28.00Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
28.00Single6H7JIsoprenaline6H7J-β1-Isoprenaline
28.00Single6J21Aprepitant6J21-NK1-Aprepitant
28.00Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
28.00Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
28.00Single6OL9Tiotropium6OL9-M5-Tiotropium
28.00Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
28.00Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
28.00Single7PX4PSB-21137PX4-A2A-PSB-2113
28.00Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
28.00Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
28.00Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
28.00Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
28.00Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
28.00Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
28.00Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
28.00Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
28.00Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
28.00Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
28.00Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
28.00Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
28.00Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
28.00Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
28.00Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
28.00Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
28.00Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
28.00Single9F33FOB02-04A9F33-D3-FOB02-04A-Go1/β1/γ2
28.00Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
28.00Consensus5ht1_offOrthosteric Ligand5ht1b_off
28.00Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
28.00Consensusa2_onOrthosteric Liganda2b_on
28.00Consensusa2_on_gpOrthosteric Liganda2b_on_gp
28.00Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
28.00Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
28.00Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
28.00Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
28.00Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
28.00Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
28.00Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
28.00Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
28.00Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
27.59Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
27.59Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
27.59Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
27.59Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
27.59Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
27.59Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
27.27Single3ODUIT1t3ODU-CXCR4-IT1t
27.27Single3PWHZM-2413853PWH-A2A-ZM-241385
27.27Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
27.27Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
27.27Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
27.27Single6DS0Ly2660976DS0-5-HT2B-Ly266097
27.27Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
27.27Single6ME2Ramelteon6ME2-MT1-Ramelteon
27.27Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
27.27Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
27.27Single7BR3Elagolix7BR3-GnRH1-Elagolix
27.27Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
27.27Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
27.27Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
27.27Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
27.27Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
27.27Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
27.27Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
27.27Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
27.27Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
27.27Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
27.27Single7XRRLemborexant7XRR-OX2-Lemborexant
27.27Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
27.27Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
27.27Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
27.27Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
27.27Single8IWESpermidine8IWE-TA9-Spermidine
27.27Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
27.27Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/β1/γ2
27.27Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.27Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.27Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.27Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
27.27Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
27.27Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
27.27Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
27.27Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
27.27Consensusalpha2_offOrthosteric Ligandalpha2c_off
27.27Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
27.27Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
27.27Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
27.27Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
27.27Consensusorexin_offOrthosteric Ligandox2_off ox1_off
27.27Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
27.27Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
27.27Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
27.27Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
27.27Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
27.27Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
26.92Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
26.92Single4XEENeurotensin4XEE-NTS1-Neurotensin
26.92Single4XESNeurotensin4XES-NTS1-Neurotensin
26.92Single5CXVTiotropium5CXV-M1-Tiotropium
26.92Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
26.92Single5TZYMK8666; PubChem 1270535975TZY-FFA1-MK8666; PubChem 127053597
26.92Single6CM4Risperidone6CM4-D2-Risperidone
26.92Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
26.92Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
26.92Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
26.92Single6YVRNTS8-136YVR-NTS1-NTS8-13
26.92Single7DFPSpiperone7DFP-D2-Spiperone
26.92Single7K15MKD0467K15-BLT1-MKD046-Na
26.92Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
26.92Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
26.92Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
26.92Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
26.92Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
26.92Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
26.92Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
26.92Single8XQJJN2418XQJ-Apelin-JN241
26.92Single8XWACXCL18XWA-CXCR2-CXCL1
26.92Single8XWMCXCL68XWM-CXCR2-CXCL6
26.92Single8XWSCXCL58XWS-CXCR2-CXCL5
26.92Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
26.92Single8XYIVUF106618XYI-CXCR3-VUF10661
26.92Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
26.92Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
26.92Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
26.92Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
26.92Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
26.92Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
26.92Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
26.92Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
26.92Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
26.92Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
26.67Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
26.67Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
26.67Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
26.67Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
26.67Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
26.47Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
26.47Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
26.47Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
26.47Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
26.47Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
26.32Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
26.09Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
26.09Single2YDOAdenosine2YDO-A2A-Adenosine
26.09Single3REYXAC3REY-A2A-XAC
26.09Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
26.09Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
26.09Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
26.09Single4ZJCSB-6740424ZJC-OX1-SB-674042
26.09Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
26.09Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
26.09Single5IUBQ274563445IUB-A2A-Q27456344-Na
26.09Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
26.09Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
26.09Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
26.09Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
26.09Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
26.09Single6A94Zotepine6A94-5-HT2A-Zotepine
26.09Single6AQFZM-2413856AQF-A2A-ZM-241385
26.09Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
26.09Single6TPGEMPA6TPG-OX2-EMPA
26.09Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
26.09Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
26.09Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
26.09Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
26.09Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
26.09Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
26.09Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
26.09Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
26.09Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
26.09Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
26.09Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
26.09Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
26.09Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
26.09Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
26.09Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
26.09Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
26.09Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.09Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
26.09Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
26.09Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
26.09Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
26.09Single8K9LDamgo8K9L-μ-Damgo-VV9-Gi3/β1/γ1
26.09Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
26.09Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
26.09Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
26.09Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
26.09Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.09Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.09Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
26.09Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
26.09Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
26.09Single8ZPNAMD31008ZPN-CXCR4-AMD3100-Cholesterol
26.09Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
26.09Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
26.09Consensusalpha1_onOrthosteric Ligandalpha1a_on
26.09Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
26.09Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
26.09Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
26.09Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
26.09Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
26.09Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
26.09Consensusgrh_offOrthosteric Ligandgnrh1_off
25.93Single4BUONeurotensin4BUO-NTS1-Neurotensin
25.93Single5X93K-87945X93-ETB-K-8794
25.93Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
25.93Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
25.93Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.93Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-PubChem 118610427-chim(NtGi1-Go)/β1/γ2
25.93Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
25.93Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
25.93Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
25.93Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
25.93Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
25.93Single8XVUCXCL28XVU-CXCR2-CXCL2
25.93Single8XWFCXCL38XWF-CXCR2-CXCL3
25.93Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
25.93Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
25.93Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
25.81Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
25.81Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
25.81Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
25.81Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
25.81Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
25.00Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
25.00Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
25.00Single3EMLZM-2413853EML-A2A-ZM-241385
25.00Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
25.00Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
25.00Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
25.00Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
25.00Single4MQSIperoxo4MQS-M2-Iperoxo
25.00Single4QIMANTA XV4QIM-SMO-ANTA XV
25.00Single4U14Tiotropium4U14-M3-Tiotropium
25.00Single5DHHSB-6121115DHH-NOP-SB-612111
25.00Single5EE7MK08935EE7-Glucagon-MK0893
25.00Single5IU8Q274563475IU8-A2A-Q27456347-Na
25.00Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
25.00Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
25.00Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
25.00Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
25.00Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
25.00Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
25.00Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
25.00Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
25.00Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
25.00Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
25.00Single6S0LZM-2413856S0L-A2A-ZM-241385
25.00Single6TQ9SB-4081246TQ9-OX1-SB-408124
25.00Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
25.00Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
25.00Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
25.00Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
25.00Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
25.00Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
25.00Single7PYRPSB-21157PYR-A2A-PSB-2115
25.00Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
25.00Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
25.00Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
25.00Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
25.00Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
25.00Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
25.00Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
25.00Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
25.00Single8A2OTheophylline8A2O-A2A-Theophylline-Na
25.00Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
25.00Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
25.00Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
25.00Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
25.00Single8IWM2-Phenylethylamine8IWM-TA9-2-Phenylethylamine
25.00Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single8JJOAlprenolol8JJO-β2-Alprenolol
25.00Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
25.00Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
25.00Single8RLNLUF58348RLN-A2A-LUF5834
25.00Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
25.00Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
25.00Single9CHUNoradrenaline9CHU-β2-Noradrenaline
25.00Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
25.00Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
25.00Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
25.00Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
25.00Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
25.00Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
25.00Consensusalpha2_onOrthosteric Ligandalpha2b_on
25.00Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
25.00Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
25.00Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
25.00Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
25.00Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
25.00Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
25.00Consensusgs_histamineOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
25.00Consensush2_onOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
25.00Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
25.00Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
25.00Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
25.00Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
25.00Consensusp2y_offOrthosteric Ligandp2y1_off
24.32Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
24.32Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
24.32Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
24.32Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
24.24Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
24.24Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
24.24Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
24.14Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
24.14Single8WKYPG-9348WKY-MC4-PG-934
24.14Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
24.14Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
24.14Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
24.14Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
24.14Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
24.14Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
24.14Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
24.00Single4NTJAZD12834NTJ-P2Y12-AZD1283
24.00Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
24.00Single5WQCEMPA5WQC-OX2-EMPA
24.00Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
24.00Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
24.00Single6LUQHaloperidol6LUQ-D2-Haloperidol
24.00Single6PS6Timolol6PS6-β2-Timolol
24.00Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
24.00Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
24.00Single6TP6Filorexant6TP6-OX1-Filorexant
24.00Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
24.00Single7C4SS1P7C4S-S1P3-S1P
24.00Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
24.00Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
24.00Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
24.00Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
24.00Single7WC6LSD7WC6-5-HT2A-LSD
24.00Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
24.00Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
24.00Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
24.00Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
24.00Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
24.00Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
24.00Single8QOTNanobody-E8QOT-μ-Nanobody-E
24.00Single8WGBW9R8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
24.00Single8ZMFA1L108ZMF-5-HT2C-A1L10
24.00Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
24.00Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
24.00Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
24.00Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
24.00Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
24.00Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
23.81Single4XNWMRS25004XNW-P2Y1-MRS2500
23.81Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/β1/γ2
23.81Single7WC5Psilocin7WC5-5-HT2A-Psilocin
23.81Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
23.81Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
23.81Single8IW72-Phenylethylamine8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
23.81Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
23.81Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
23.81Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
23.81Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
23.81Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
23.81Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
23.81Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
23.81Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
23.81Consensus5ht2_onOrthosteric Ligand5ht2b_on
23.81Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.81Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
23.81Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
23.81Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
23.81Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
23.81Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
23.81Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
23.81Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
23.68Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
23.68Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
23.53Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
23.53Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
23.33Single6HLOAprepitant6HLO-NK1-Aprepitant
23.33Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
23.33Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
23.33Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
23.33Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
23.08Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
23.08Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
23.08Single4DJHJDTic4DJH-κ-JDTic
23.08Single5TZRMK86665TZR-FFA1-MK8666
23.08Single5XRAAM115425XRA-CB1-AM11542
23.08Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
23.08Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
23.08Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
23.08Single6TQ7SB-3348676TQ7-OX1-SB-334867
23.08Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
23.08Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
23.08Single7FEECP559407FEE-CB1-CP55940-ZCZ011
23.08Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
23.08Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
23.08Single7R0CAVP7R0C-V2-AVP-Arrestin2
23.08Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
23.08Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
23.08Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
23.08Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.08Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
23.08Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
23.08Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
23.08Single8XVLZibotentan8XVL-ETA-Zibotentan
23.08Single9GE2ML1849GE2-GPR55-ML184-Cholesterol-chim(CtGi1-G13)/β1/γ2
23.08Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
23.08Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
23.08Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
23.08Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
23.08Consensusneurotensin_onOrthosteric Ligandnts1_on
23.08Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
23.08Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
22.86Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
22.86Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
22.86Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
22.73Single3PBLEticlopride3PBL-D3-Eticlopride
22.73Single4O9RCyclopamine4O9R-SMO-Cyclopamine
22.73Single6HLLCP999946HLL-NK1-CP99994
22.73Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
22.73Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
22.73Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
22.73Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
22.73Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
22.73Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
22.73Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.73Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
22.73Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
22.73Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
22.73Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
22.73Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
22.73Single8YN2Histamine8YN2-H1-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
22.73Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
22.73Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
22.73Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
22.73Single8YN7Immethridine8YN7-H3-Immethridine-Go1/β1/γ2
22.73Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
22.73Single9B9Y7DY9B9Y-CB1-7DY
22.73Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
22.73Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
22.73Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
22.73Consensusgq_nucleotideOrthosteric Ligandgq_p2y
22.73Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
22.73Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
22.58Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
22.58Single6W25SHU91196W25-MC4-SHU9119-Ca
22.58Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
22.58Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
22.22Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
22.22Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
22.22Single4N4WSANT-14N4W-SMO-SANT-1
22.22Single6KQICP559406KQI-CB1-CP55940-Org27569
22.22Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
22.22Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
22.22Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
22.22Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
22.22Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/β1/γ2
22.22Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
22.22Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
22.22Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
22.22Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.22Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
22.22Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
22.22Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
21.88Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
21.88Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
21.88Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
21.88Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
21.88Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
21.88Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
21.74Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
21.74Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
21.74Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
21.74Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
21.74Single4BWBNeurotensin4BWB-NTS1-Neurotensin
21.74Single4QINSAG1.54QIN-SMO-SAG1.5
21.74Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
21.74Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
21.74Single5WS3EMPA5WS3-OX2-EMPA
21.74Single5ZKQABT-4915ZKQ-PAF-ABT-491
21.74Single6B73MP11046B73-κ-MP1104
21.74Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
21.74Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
21.74Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
21.74Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
21.74Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
21.74Single6TODEMPA6TOD-OX1-EMPA-Na
21.74Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
21.74Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
21.74Single7F8ULintitript7F8U-CCKA-Lintitript
21.74Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
21.74Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
21.74Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.74Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
21.74Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
21.74Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
21.74Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
21.74Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
21.74Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
21.74Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.74Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
21.74Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
21.74Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
21.74Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
21.74Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
21.74Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
21.74Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
21.74Single8Y0HVUF114188Y0H-CXCR3-VUF11418
21.74Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
21.74Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ
21.74Single9BA0A1AKN9BA0-CB1-A1AKN
21.74Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
21.74Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
21.74Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.74Consensusangiotensin_offOrthosteric Ligandat1_off
21.74Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
21.74Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
21.74Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
21.74Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
21.74Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
21.74Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
21.74Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
21.74Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
21.74Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
21.62Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
21.62Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
21.43Single6K1QIRL25006K1Q-ETB-IRL2500
21.43Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
21.43Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
21.43Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
21.43Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.43Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
21.43Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
21.43Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
21.21Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
21.05Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
21.05Single8GEJConstrained Epinephrine8GEJ-β2-Constrained Epinephrine-Gs/β1/γ2
21.05Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
21.05Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
20.83Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
20.83Single3RZECidoxepin3RZE-H1-Cidoxepin
20.83Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
20.83Single5IU7Q274563465IU7-A2A-Q27456346-Na
20.83Single5JTBZM-2413855JTB-A2A-ZM-241385
20.83Single5UVIZM-2413855UVI-A2A-ZM-241385
20.83Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
20.83Single6IQLL7458706IQL-D4-L745870
20.83Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
20.83Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
20.83Single6TPNHTL66416TPN-OX2-HTL6641
20.83Single6V9SGTPL114036V9S-OX1-GTPL11403
20.83Single6VI4JDTic6VI4-κ-JDTic
20.83Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
20.83Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
20.83Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
20.83Single6ZG9GSK10347026ZG9-M1-GSK1034702
20.83Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
20.83Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
20.83Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
20.83Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
20.83Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
20.83Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
20.83Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
20.83Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
20.83Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
20.83Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
20.83Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
20.83Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
20.83Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
20.83Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
20.83Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
20.83Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
20.83Single8YN8Proxyfan8YN8-H3-Proxyfan-Go1/β1/γ2
20.83Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
20.83Single9BJKNaloxone9BJK-μ-Naloxone-NAM
20.83Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Cholesterol-Gi1/β1/γ2
20.83Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
20.83Consensusa2_offOrthosteric Liganda2a_off
20.83Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
20.83Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
20.83Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
20.83Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
20.83Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
20.83Consensusopsins_offOrthosteric Ligandrhodopsin_off
20.83Consensussensory_offOrthosteric Ligandopsins_off
20.69Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
20.69Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
20.69Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
20.69Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
20.69Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
20.69Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
20.69Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
20.69Consensuskisspeptin_onOrthosteric Ligandkiss1_on
20.59Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
20.59Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
20.51Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
20.51Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
20.00Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
20.00Single4DAJTiotropium4DAJ-M3-Tiotropium
20.00Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
20.00Single4YAYZD-71554YAY-AT1-ZD-7155
20.00Single5DHGC-355DHG-NOP-C-35
20.00Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
20.00Single5TGZAM65385TGZ-CB1-AM6538
20.00Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
20.00Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
20.00Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
20.00Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
20.00Single6GPSMK08126GPS-CCR2-MK0812
20.00Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
20.00Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
20.00Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
20.00Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
20.00Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
20.00Single7QA8Peptide7QA8-STE2-Peptide
20.00Single7QA8Peptide7QA8-STE2-Peptide
20.00Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
20.00Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
20.00Single7WC4Serotonin7WC4-5-HT2A-Serotonin
20.00Single7YXAONO-54306087YXA-S1P5-ONO-5430608
20.00Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
20.00Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
20.00Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
20.00Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
20.00Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
20.00Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
20.00Single8IEBA1LYA8IEB-GPR156-A1LYA
20.00Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
20.00Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
20.00Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
20.00Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
20.00Single8PWNTheophylline8PWN-A2A-Theophylline
20.00Single8X63Mepyramine8X63-H1-Mepyramine
20.00Single8X64Desloratadine8X64-H1-Desloratadine
20.00Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
20.00Single9B9ZA1AKO9B9Z-CB1-A1AKO
20.00Single9IYAONO-97105319IYA-GPR55-ONO-9710531
20.00Consensuscck_offOrthosteric Ligandccka_off
20.00Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
20.00Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
20.00Consensushistamine_offOrthosteric Ligandh1_off
19.44Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
19.44Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
19.44Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
19.44Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
19.35Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
19.35Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
19.35Single8IEBA1LYA8IEB-GPR156-A1LYA
19.35Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
19.23Single4JKVTaladegib4JKV-SMO-Taladegib
19.23Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
19.23Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
19.23Single5XPRBosentan5XPR-ETB-Bosentan
19.23Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
19.23Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
19.23Single6GPXMK08126GPX-CCR2-MK0812
19.23Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
19.23Single7W41PD1762527W41-BB2-PD176252
19.23Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
19.23Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
19.23Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
19.23Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
19.23Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
19.23Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
19.23Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
19.23Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
19.23Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
19.23Consensusblt_offOrthosteric Ligandblt1_off
19.23Consensusbombesin_offOrthosteric Ligandbb2_off
19.23Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
19.23Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
19.23Consensusep_offOrthosteric Ligandep4_off
19.23Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
19.05Single3OE8IT1t3OE8-CXCR4-IT1t
19.05Single3RFMCaffeine3RFM-A2A-Caffeine
19.05Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
19.05Single8WC5Tetramethylammonium Ion8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
19.05Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
19.05Consensussensory_onOrthosteric Ligandopsins_on
18.75Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
18.75Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
18.60Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
18.52Single4BV0Neurotensin4BV0-NTS1-Neurotensin
18.52Single5V56TC1145V56-SMO-TC114
18.52Single5V57TC1145V57-SMO-TC114
18.52Single6J20Aprepitant6J20-NK1-Aprepitant
18.52Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
18.52Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
18.52Single8EA0Iperoxo8EA0-M3-Iperoxo
18.52Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.52Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
18.52Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
18.52Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
18.52Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
18.52Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
18.52Single9BJKNAM9BJK-μ-Naloxone-NAM
18.52Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
18.52Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
18.52Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
18.52Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
18.52Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
18.52Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
18.52Consensustachykinin_offOrthosteric Ligandnk1_off
18.42Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
18.42Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
18.18Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
18.18Single3PQRAll-trans-Retinal3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
18.18Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
18.18Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
18.18Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
18.18Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
18.18Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
18.18Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.18Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
18.18Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
18.18Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
18.18Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
18.18Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
18.18Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
17.86Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
17.86Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
17.86Single4PY02MeSATP4PY0-P2Y12-2MeSATP
17.86Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
17.86Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
17.86Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
17.86Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
17.86Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
17.86Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
17.86Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
17.86Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
17.65Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
17.65Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
17.65Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
17.65Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
17.50Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
17.50Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
17.50Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
17.39Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
17.39Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
17.39Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
17.39Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
17.39Single5L7IVismodegib5L7I-SMO-Vismodegib
17.39Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
17.39Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
17.39Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
17.39Single6LI0C176LI0-GPR52-C17
17.39Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
17.39Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
17.39Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
17.39Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
17.39Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
17.39Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
17.39Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go1/β1/γ2
17.39Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
17.39Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
17.24Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
17.24Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
17.24Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
17.24Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
17.24Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
17.24Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
17.24Single8XVJMacitentan8XVJ-ETA-Macitentan
17.24Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
17.14Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
17.14Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
17.14Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
16.67Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
16.67Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
16.67Single4S0VSuvorexant4S0V-OX2-Suvorexant
16.67Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
16.67Single5U09Taranabant5U09-CB1-Taranabant
16.67Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
16.67Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
16.67Single6TPJSuvorexant6TPJ-OX2-Suvorexant
16.67Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
16.67Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
16.67Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
16.67Single7F8YDevazepide7F8Y-CCKA-Devazepide
16.67Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
16.67Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
16.67Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
16.67Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
16.67Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
16.67Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
16.67Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
16.67Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
16.67Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
16.67Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
16.67Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
16.67Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
16.67Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
16.67Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
16.67Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
16.67Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
16.67Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
16.22Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
16.22Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
16.22Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
16.13Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
16.13Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
16.13Single8IEIA1LYA8IEI-GPR156-A1LYA
16.13Single8IEPA1LYA8IEP-GPR156-A1LYA
16.13Single8IEPA1LYA8IEP-GPR156-A1LYA
16.13Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
16.13Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
16.13Single8KIGSHU91198KIG-MC3-SHU9119-Ca
16.00Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
16.00Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
16.00Single6TP3Nemorexant6TP3-OX1-Nemorexant
16.00Single6ZINSR486926ZIN-NTS1-SR48692
16.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
16.00Single7VODCariprazine7VOD-5-HT2A-Cariprazine
16.00Single8K2WAMG4878K2W-CXCR3-AMG487
16.00Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
16.00Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
16.00Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
16.00Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
15.79Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
15.62Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
15.62Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
15.38Single5DSGTiotropium5DSG-M4-Tiotropium
15.38Single5T04Neurotensin5T04-NTS1-Neurotensin
15.38Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
15.38Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/β1/γ2
15.38Single7F83PF-051904577F83-Ghrelin-PF-05190457
15.38Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
15.38Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
15.38Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
15.38Single8TH3AT118-H Nanobody8TH3-AT1-AT118-H Nanobody
15.38Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
15.38Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
15.38Single9IMATalquetamab9IMA-GPRC5D-Talquetamab
15.38Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
15.00Single5MZPCaffeine5MZP-A2A-Caffeine-Na
15.00Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
15.00Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
14.81Single5CGCHTL142425CGC-mGlu5-HTL14242
14.81Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
14.81Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
14.81Single6HLPNetupitant6HLP-NK1-Netupitant
14.81Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
14.81Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
14.81Single6Z4SSR486926Z4S-NTS1-SR48692
14.81Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
14.81Single7SINNPS-21437SIN-CaS-NPS-2143
14.81Single7SINNPS-21437SIN-CaS-NPS-2143
14.81Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
14.81Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
14.81Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
14.81Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
14.71Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
14.29Single3PXOAll-trans-Retinal3PXO-Rhodopsin-All-trans-Retinal
14.29Single5DYSAll-trans-Retinal5DYS-Rhodopsin-All-trans-Retinal
14.29Single6E59L-7607356E59-NK1-L-760735
14.29Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
14.29Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
14.29Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
14.29Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
14.29Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
14.29Single8YNTSNAP-948478YNT-MCH1-SNAP-94847
14.29Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
13.79Single5X33BIIL2605X33-BLT1-BIIL260
13.79Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
13.79Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
13.79Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
13.79Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
13.79Single8XJNCloprosetnol8XJN-TP-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
13.79Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
13.79Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
13.64Single2HPYAll-trans-Retinal2HPY-Rhodopsin-All-trans-Retinal
13.64Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
13.64Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
13.64Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
13.64Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/β1/γ2
13.51Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
13.33Single5CGDHTL142425CGD-mGlu5-HTL14242
13.33Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
13.33Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
13.33Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
13.33Consensustp_onOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
13.33Consensustp_on_gpOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
13.04Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
13.04Single3UZAGTPL92363UZA-A2A-GTPL9236
13.04Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
13.04Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
13.04Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
13.04Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
13.04Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
13.04Single8JPSCCL78JPS-ACKR1-CCL7
13.04Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
13.04Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
13.04Consensusgi_sensoryOrthosteric Ligandgi_opsins
13.04Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
13.04Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
12.90Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.90Single8IEIA1LYA8IEI-GPR156-A1LYA
12.50Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
12.50Single6TP4ACT-4622066TP4-OX1-ACT-462206
12.50Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
12.50Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
12.50Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
12.50Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
12.50Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
12.50Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
12.50Single9EPRRetinal9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
12.00Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
12.00Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
12.00Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
12.00Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
12.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
12.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
12.00Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
12.00Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
12.00Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
12.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
12.00Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
11.54Single6TPKRetosiban6TPK-OT-Retosiban
11.54Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
11.54Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.54Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
11.54Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
11.54Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
11.54Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
11.54Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
11.54Consensusvasop-oxy_offOrthosteric Ligandot_off
11.43Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
11.43Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
11.43Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
11.11Single6IIVDaltroban6IIV-TP-Daltroban
11.11Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
11.11Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
11.11Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
11.11Single9IVGGLP-1 (Truncated)9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
11.11Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
11.11Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
10.71Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
10.71Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
10.71Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
10.71Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
10.71Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
10.71Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
10.71Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
10.71Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
10.34Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
10.34Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
10.34Single8GDBPGE28GDB-EP4-PGE2-Gs/β1/γ2
10.34Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
10.00Single6IIURamatroban6IIU-TP-Ramatroban
9.68Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
9.52Single4A4MAll-trans-Retinal4A4M-Rhodopsin-All-trans-Retinal-Gt(CT)
9.52Single5EN0All-trans-Retinal5EN0-Rhodopsin-All-trans-Retinal-Gt(CT)
9.38Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
9.09Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
9.09Single7XKDBeta-Hydroxyandrosterone7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
9.09Single8HS2Fab0468HS2-GPR20-Fab046
9.09Single8X9S5alpha-DHT8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
8.70Single6OY9All-trans-Retinal6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
8.70Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
8.33Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
8.33Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
8.33Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
8.33Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
8.00Single7UL2SR486927UL2-NTS1-SR48692-Na
8.00Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
8.00Single8HSCFab0468HSC-GPR20-Fab046-Gi1/β1/γ2
8.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.00Single8YRGFospropofol8YRG-MRGPRX4-Fospropofol-chim(NtGi1-Gs-CtGq)/β1/γ2
8.00Consensusneurotensin_offOrthosteric Ligandnts1_off
8.00Consensusnts1_offOrthosteric Ligand7UL2-NTS1-SR48692-Na
7.69Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
7.69Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
7.69Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
7.69Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.69Single8T3VDocosa-4,7,10,13,16,19-Hexaenoic acid8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.69Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
7.41Single6FFIMMPEP6FFI-mGlu5-MMPEP
7.41Single7VV6C48/807VV6-MRGPRX2-C48/80
7.41Single8IYXYL-3658IYX-GPR34-YL-365
7.41Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
7.14Single6FFHFenobam6FFH-mGlu5-Fenobam
6.90Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
6.90Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
6.90Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
6.90Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67Single7P2L4YI7P2L-mGlu5-4YI
6.67Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
6.67Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
6.67Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
6.45Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.45Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
6.25Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
5.88Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.71Single7SHEPI; PE7SHE-GPR158-PI; PE
5.26Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
5.26Single6D35Cholesterol6D35-SMO-Cholesterol
5.26Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
5.26Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
5.26Single6UO8SKF975416UO8-GABAB1, GABAB2-SKF97541-GS39783
5.26Single6UO9SKF975416UO9-GABAB1, GABAB2-SKF97541
5.26Single6W2XPubChem 53110426W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
5.26Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
5.26Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
5.26Single7C7QBaclofen7C7Q-GABAB1, GABAB2-Baclofen-PubChem 7023848
5.26Single7C7SCGP546267C7S-GABAB1, GABAB2-CGP54626
5.26Single7CUMCGP546267CUM-GABAB1, GABAB2-CGP54626-Phospholipid
5.26Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.26Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.26Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.26Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.26Single7DGEQuisqualate7DGE-mGlu1; mGlu1-Quisqualate
5.26Single7DTTCa7DTT-CaS-Ca-Ca
5.26Single7DTTCa7DTT-CaS-Ca-Ca
5.26Single7DTUTryptophan7DTU-CaS-Tryptophan
5.26Single7DTUTryptophan7DTU-CaS-Tryptophan
5.26Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
5.26Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
5.26Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
5.26Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
5.26Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.26Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.26Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.26Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.26Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
5.26Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
5.26Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
5.26Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
5.26Single7EB2Baclofen7EB2-GABAB2; GABAB1-Baclofen-rac-BHFF-Gi1/β1/γ2
5.26Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
5.26Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
5.26Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
5.26Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
5.26Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
5.26Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
5.26Single7FIHhCG7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
5.26Single7FIIhCG7FII-LH-hCG-chim(NtGi1-Gs)/β1/γ2
5.26Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
5.26Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
5.26Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
5.26Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
5.26Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.26Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.26Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.26Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.26Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
5.26Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
5.26Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
5.26Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
5.26Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
5.26Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
5.26Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
5.26Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
5.26Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
5.26Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
5.26Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.26Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.26Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.26Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.26Single7T9NM22 Fab7T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
5.26Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
5.26Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
5.26Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
5.26Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
5.26Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
5.26Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
5.26Single7XW6M22 Fab7XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
5.26Single7XW7K1-707XW7-TSH-K1-70
5.26Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
5.26Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
5.26Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
5.26Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
5.26Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
5.26Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
5.26Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
5.26Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
5.26Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
5.26Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
5.26Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
5.26Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
5.26Single8JD0Glutamate8JD0-mGlu2; mGlu3-Glutamate-NAM563
5.26Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
5.26Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
5.26Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
5.26Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
5.26Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
5.26Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
5.26Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
5.26Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
5.26Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
5.26Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
5.26Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
5.26Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
5.26Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
5.26Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
5.26Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
5.26Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
5.26Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
5.26Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
5.26Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
5.26Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
5.26Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
5.26Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
5.26Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
5.26Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
5.26Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
5.26Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
5.26Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
5.26Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
5.26Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
5.26Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
5.26Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
5.26Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
5.26Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
5.26Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
5.26Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
5.26Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
5.26Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
5.26Single8WG9(2S)-2-amino-4-phosphonobutanoic acid8WG9-mGlu4; mGlu2-(2S)-2-amino-4-phosphonobutanoic acid
5.26Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
5.26Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
5.26Single8WGCLY3792688WGC-mGlu4; mGlu2-LY379268
5.26Single8WGDWAG/WA68WGD-mGlu4; mGlu2-WAG/WA6
5.26Single8WGDWAG/WA68WGD-mGlu4; mGlu2-WAG/WA6
5.26Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
5.26Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
5.26Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.26Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.26Single8WVXNorrin8WVX-LGR4-Norrin
5.26Single8WVYNorrin8WVY-LGR4-Norrin
5.26Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
5.26Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
5.26Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
5.26Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
5.26Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
5.26Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
5.26Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
5.26Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
5.26Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
5.26Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
5.26Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
5.26Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
5.26Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
5.26Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
5.26Single8XUMR-spondin-28XUM-LGR4-R-spondin-2
5.26Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
5.26Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
5.26Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
5.26Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
5.26Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
5.26Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
5.26Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
5.26Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
5.26Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
5.26Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
5.26Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
5.26Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
5.26Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
5.26Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
5.26Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
5.26Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
5.26Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
5.26Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
5.26Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
5.26Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
5.00Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
5.00Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
5.00Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
5.00Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
5.00Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
5.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
5.00Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
5.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
5.00Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
5.00Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
5.00Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
5.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
4.76Single7KNUCalcitonin gene-related peptide-17KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
4.76Single7T9MCS-17 Antibody7T9M-TSH-CS-17 Antibody
4.76Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
4.55Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
4.55Single7FIGhCG7FIG-LH-hCG-chim(NtGi1L-Gs)/β1/γ2
4.55Single7UTZTR14027UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
4.55Single7XW5TSH7XW5-TSH-TSH-ML109-Gs/β1/γ2
4.55Single7ZI0Cholesterol7ZI0-SMO-SAG-Cholesterol
4.35Single5L7DCholesterol5L7D-SMO-Cholesterol
4.35Single7T9ITSH7T9I-TSH-TSH-Gs/β1/γ2
4.35Single8I2GGlycoprotein hormones alpha chain8I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
4.35Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
4.17Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
4.00Single7F61Cholesterol7F61-H3-PF-03654746-Cholesterol
4.00Single8J6QCompound 9n8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
4.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
3.85Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.85Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
3.85Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
3.85Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
3.85Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/β1/γ2
3.85Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
3.85Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
3.70Single7VVOPTH7VVO-PTH1-PTH-Gs/β1/γ2
3.45Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
3.33Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
3.33Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
3.33Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
3.23Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
3.23Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Cholesterol-Gi1/β1/γ1
3.12Single7SHEPI; PE7SHE-GPR158-PI; PE
2.86Single8XFTR-spondin-28XFT-LGR4-R-spondin-2-ZNRF3
2.86Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-Cholesterol-ZNRF3
2.78Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
2.70Single8WVUR-spondin-18WVU-LGR4-R-spondin-1-RNF43
2.70Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-Cholesterol-ZNRF3
2.63Single8XFPR-spondin-28XFP-LGR4-R-spondin-2-ZNRF3
2.44Single8XFSR-spondin-28XFS-LGR4-R-spondin-2-ZNRF3

Consensus Members
Id Members
at1_on 7F6G-AT1-SAR1-AngII-Gq/β1/γ2
Net Summary
Imin 3.07
Number of Linked Nodes 253
Number of Links 294
Number of Hubs 40
Number of Links mediated by Hubs 178
Number of Communities 7
Number of Nodes involved in Communities 63
Number of Links involved in Communities 88
Path Summary
Number Of Nodes in MetaPath 50
Number Of Links MetaPath 49
Number of Shortest Paths 68830
Length Of Smallest Path 3
Average Path Length 15.3139
Length of Longest Path 33
Minimum Path Strength 1.21
Average Path Strength 5.63724
Maximum Path Strength 46.545
Minimum Path Correlation 0.7
Average Path Correlation 0.93226
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 4.34783
Average % Of Corr. Nodes 46.8589
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 42.1279
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following differences:
Id1st Network2nd Network
angiotensin_off_onangiotensin_offangiotensin_on
This network is also present in following consensuses:
IdComponents
peptide_oncck_on
angiotensin_on
apelin_on
bombesin_on
bradykinin_on
compl-peptide_on
endothelin_on
formylpeptide_on
galanin_on
ghrelin_on
kisspeptin_on
melanocortin_on
motilin_on
neuromedin-u_on
npy_on
neurotensin_on
opioid_on
orexin_on
relaxin_on
somatostatin_on
tachykinin_on
trh_on
vasop-oxy_on



You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download angiotensin_on.zip



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