Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
1G.S1.05 6.93625419
2G.S1.06 4.028754198
3G.S1.07 5.1875419
4G.H1.01 2.613754199
5G.S2.03 5.466519
6G.S2.08 7.6365105
7G.S3.03 5.231437107
8G.S3.04 6.51125416
9G.S3.06 8.839515
10G.S3.07 3.884199
11G.H2.06 6.345719
12G.H2.07 5.444519
13G.H2.09 5.39625418
14G.h2s4.01 7.573519
15G.h2s4.02 5.27417
16G.S4.02 5.502518
17G.S4.03 3.51625407
18G.S4.04 6.01833619
19G.s4h3.01 6.20254207
20G.s4h3.03 4.77418
21G.H3.17 7.6515
22G.H3.18 4.753519
23G.S5.02 4.76125406
24G.S5.04 5.008519
25G.S5.05 5.530717119
26G.S5.07 5.4409
27G.HG.05 5.15375405
28G.HG.07 6.6425409
29G.HG.08 3.0415206
30G.hgh4.02 5.9756217
31G.H4.10 10.66254216
32G.H4.15 6.90375418
33G.H4.16 3.68625413
34G.h4s6.11 5.5175407
35G.h4s6.12 7.79625494
36G.S6.01 3.92125415
37G.S6.02 6.523597
38G.H5.08 4.973336108
39G.H5.13 5.691598
40G.H5.17 5.602595
41G.H5.26 5.18875495
42b.lhb1x6 3.0735123
43b.b1x3 6.81875437
44b.l1x3 9.029539
45b.l1x6 12.5387419
46b.b2x1 5.71618
47b.b2x3 3.80625436
48b.b2x5 8.21083637
49b.l3x1 7.29625419
50b.l3x2 5.35125439
51b.b4x3 4.7415157
52b.b4x4 9.26625438
53b.b4x5 4.878754187
54b.b4x6 11.952539
55b.b5x2 5.6595177
56b.b5x3 7.32083639
57b.b5x5 5.2154185
58b.b5x7 5.8575407
59b.l5x1 5.2554158
60b.l5x5 7.42286719
61b.b6x3 2.60754158
62b.b6x5 5.84406
63b.b7x1 7.108754134
64b.b7x4 4.768754158
65b.b8x3 4.378754136
66b.b8x4 6.037506
67b.l8x3 3.73254263
68b.l8x5 4.201254263
69b.l9x3 7.011579
70b.l9x6 5.36188818
71b.b10x3 4.075478
72b.b10x5 6.3255139
73b.l10x1 4.86875403
74b.b11x4 5.9625479
75b.l11x2 6.385579
76b.b12x5 4.84125446
77b.b12x6 9.63678
78b.b12x7 5.50125449
79b.b13x7 7.791547
80b.l13x3 8.085649
81b.l13x6 7.4925419
82b.l13x7 4.393549
83b.b14x1 5.2225418
84b.b14x3 3.863545
85b.b15x1 7.3375449
86b.b15x2 8.0325416
87b.b15x3 3.8375449
88b.l15x1 5.42167617
89b.l15x2 6.282549
90b.b16x4 9.57546
91b.b16x5 5.4025405
92b.b16x6 8.27583648
93b.l16x3 4.00254163
94b.b17x7 7.88418
95b.l17x3 9.155619
96b.l17x6 8.114519
97b.b18x3 5.2825418
98b.b18x5 5.86505
99b.l18x1 8.735666
100b.l18x2 7.0675467
101b.l18x3 10.2275465
102b.b19x2 6.89833616
103b.b19x4 6.89625418
104b.l19x2 7.6575419
105b.b20x2 6.525416
106b.b20x4 9.556518
107b.b20x5 4.07625407
108b.b20x6 7.34616
109b.b21x1 8.0025417
110b.b21x2 4.5275406
111b.b21x7 5.9725605
112b.l21x5 3.612584
113b.l21x7 4.88485
114b.b22x5 4.94625867
115b.l22x5 6.1035129
116b.b23x2 5.93466
117b.b23x6 7.11143787
118b.b24x2 3.669585
119b.b24x3 3.7725455
120b.b24x4 6.61917686
121b.b24x5 4.645405
122b.b24x6 6.4925488
123b.b24x7 6.824129
124b.l24x2 5.043754126
125b.l24x3 5.40625405
126b.b25x3 5.62485
127b.b25x7 7.655457
128b.l25x3 7.638559
129b.b26x3 3.55917656
130b.l26x1 7.3437
131b.l26x5 4.5125635
132b.l27x1 11.2106819
133b.l27x2 5.589559
134b.b28x4 8.09875456
135b.b28x5 3.5475435
136b.b28x6 8.17667659
137g.h2x11 12.2213466
138g.ctx3 5.334176279
139g.ctx6 2.555406
140g.ctx14 4.77071739
141g.ctx15 7.66375439
142g.ctx16 4.88389938
143Lig 12.63613220
144NT.C90 3.17427
1451x27 3.712525
1461x32 6.63375426
1471x43 4.828754147
1481x50 3.58125409
149I1x50 4.5725407
1502x39 5.0175248
1512x46 5.4275409
1522x50 6.3325409
1532x53 5.3825428
1542x54 3.654146
1552x56 8.50125426
1562x57 4.2115147
1572x60 5.7725427
1582x64 6.47125424
159E1x50 7.63429
160E1x52 4.09875427
1613x30 3.505406
1623x31 4.03125405
1633x33 7.059524
1643x50 6.866509
1653x51 5.87625408
166I2x52 4.375405
1674x41 5.57405
1684x56 4.3275425
1694x61 9.391525
170E2.H258 4.811504
171E2.Q261 4.359502
1725x32 5.05375404
1735x35 9.365423
1745x39 7.78625427
1755x40 9.1425405
1765x42 7.81125424
1775x43 5.036526
1785x44 6.16625426
1795x46 7.6925425
1805x461 4.85526
1815x47 6.37375428
1825x50 4.37625409
1835x57 6.2925407
1845x58 7.16625409
1855x65 3.8465298
1866x26 5.73694
1876x29 5.53375495
1886x30 3.99125407
1896x48 5.30875828
1906x52 6.90625428
191E3.D354 4.878754301
1927x23 7.155425
1937x35 7.318523
1947x49 3.35875409
1958x50 5.343754289
1968x54 3.72375407
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1b.l2x3 b.l2x5 23.86292.975NoNo085
2b.b3x1 b.l2x3 23.58898.82NoNo058
3b.b3x1 b.b5x4 11.23782.98NoNo055
4G.S1.05 G.h2s4.01 29.564212.785YesYes199
5G.S1.05 G.S1.07 64.5126.92YesYes199
6G.S1.07 G.S4.04 99.71556.695YesYes199
7G.S4.04 G.s1h1.01 1003.01YesNo099
8G.H1.01 G.s1h1.01 99.84422.615YesNo099
9G.H1.01 G.S1.06 98.54992.82YesYes1998
10G.S1.06 G.S4.03 97.32694.28YesYes087
11G.H3.18 G.S1.05 35.40753.045YesYes199
12G.H3.15 G.H3.18 29.19383.02NoYes189
13G.H3.15 G.H3.17 29.27693.955NoYes185
14G.H3.17 b.l27x1 28.78714.685YesYes159
15b.b26x1 b.l27x1 15.52214.94NoYes099
16b.b26x1 b.b26x2 15.40423.44NoNo097
17b.b26x2 b.b2x3 15.29414.05NoYes076
18G.S4.03 G.S5.05 93.14993.14YesYes079
19b.l2x5 b.l4x2 21.507629.325NoNo054
20b.l26x5 g.ctx4 14.27865.87YesNo057
21g.ctx3 g.ctx4 16.82144.83YesNo097
22b.l22x2 g.ctx3 15.75873.46NoYes019
23b.l22x2 g.ctx2 15.70644.725NoNo013
24g.ctx2 g.h2x15 15.65843.695NoNo036
25g.h2x11 g.h2x15 16.525319.055YesNo066
26b.l18x1 g.h2x11 11.0115.67YesYes666
27b.b20x5 b.b22x5 12.28543.045YesYes077
28b.b20x5 b.b21x4 18.40113.46YesNo075
29b.b21x4 g.h2x1 17.50283.725NoNo058
30b.b21x2 g.h2x1 17.35545.73YesNo068
31b.1x18 b.b21x2 17.69673.505NoYes046
32b.1x14 b.1x18 61.21153.13NoNo044
33b.1x14 b.1x15 60.53464.805NoNo047
34b.1x12 b.1x15 60.19596.025NoNo067
35b.1x12 g.h1x11 58.83953.525NoNo069
36g.h1x11 g.h1x14 51.72022.65NoNo099
37b.b17x6 g.h1x14 51.37747.055NoNo079
38b.b16x4 b.b17x6 51.03449.76YesNo067
39b.b16x4 b.l13x3 13.152918.34YesYes469
40b.b14x3 b.b15x3 17.76833YesYes459
41b.b10x2 b.b14x3 25.6843.965NoYes065
42b.b10x2 b.b6x2 24.61573.38NoNo068
43b.b10x3 b.b6x2 23.54722.535YesNo088
44b.b10x3 b.b11x4 19.26834.225YesYes789
45b.b11x4 b.l9x3 12.84856.845YesYes799
46b.l4x2 g.ctx16 15.31357.735NoYes348
47b.b16x4 b.b16x6 36.54339.86YesYes468
48G.H2.07 G.h2s4.01 23.03255.51YesYes199
49G.H2.06 b.l9x6 24.90212.985YesYes198
50G.H2.05 G.H2.08 44.9042.91NoNo188
51G.H2.05 G.H2.06 44.45684.31NoYes189
52G.H2.06 b.l17x6 68.458710.37YesYes199
53G.S5.03 G.S5.05 85.03424.395NoYes089
54G.H5.10 G.S5.03 84.69543.25NoNo068
55G.H5.10 G.S6.02 84.5262.67NoYes067
56G.H5.13 G.S6.02 76.53067.47YesYes987
576x30 G.H5.13 74.04764.765YesYes078
583x50 G.H5.23 67.92875.57YesNo094
593x50 5x61 73.49393.1YesNo098
605x61 5x65 73.64213.61NoYes2988
615x65 6x30 74.38233.72YesYes087
622x39 G.H5.23 66.82635.65YesNo084
632x39 I1x52 63.74416.52YesNo2488
648x50 8x54 60.19013.755YesYes097
651x56 8x54 62.26513.77NoYes077
661x56 8x53 62.45356.545NoNo074
678x53 I1x50 62.64183.24NoYes047
682x40 I1x50 63.39336.31NoYes087
692x40 I1x52 63.580810.9NoNo088
70b.l17x5 b.l17x6 68.19654.415NoYes169
71b.l17x5 b.l19x2 68.21812.945NoYes169
72b.b19x6 b.l19x2 35.30895.15NoYes199
73b.b19x6 b.l17x3 35.187511.16NoYes199
74b.b20x6 b.l17x3 31.93484.53YesYes169
75b.b17x7 b.b20x6 53.890812.86YesYes186
76b.b17x7 b.b21x1 51.6844.18YesYes187
77b.b20x2 b.l19x2 32.706410.84YesYes169
78b.b20x2 b.b20x4 32.45966.465YesYes168
79b.b20x4 b.b20x6 31.91045.88YesYes186
80b.1x18 b.b21x1 51.90534.765NoYes047
81b.b13x7 b.b16x6 17.076416.54YesYes478
82b.b13x5 b.b13x7 16.53615.19NoYes447
83b.l4x1 g.ctx16 11.05425.28NoYes358
84b.b3x1 b.b6x5 12.08055.275NoYes056
85b.b3x3 b.b6x5 11.24835.05NoYes086
86b.b3x3 b.b4x3 10.9753.725NoYes087
87b.b13x4 b.b13x5 10.43795.495NoNo444
88b.b12x7 b.b13x4 10.11582.895YesNo494
89b.l25x6 b.l27x1 13.288423.49NoYes089
90b.l23x1 b.l25x6 13.099219.06NoNo068
91b.l21x7 b.l23x1 13.01094.665YesNo056
92b.b23x6 b.l21x7 12.26343.36YesYes875
93b.b23x6 b.b24x6 10.933311.58YesYes878
94b.b21x7 b.b24x6 11.15675.305YesYes058
957x53 8x50 58.55366.7NoYes2899
967x49 7x53 58.47133.43YesNo099
972x46 7x49 55.03054.81YesYes099
982x46 2x50 27.00716.11YesYes099
992x50 7x46 26.71868.1YesNo099
1002x54 7x46 26.51733.095YesNo069
1012x54 2x57 23.9382.945YesYes1467
1021x39 2x57 23.68343.87NoYes077
1031x39 7x39 22.47126.705NoNo075
1041x35 7x39 21.864910.215NoNo055
1051x35 7x35 20.5775.23NoYes253
1067x35 Lig 19.95337.2YesYes230
1073x37 5x461 12.19883.62NoYes066
1083x37 4x53 12.393.71NoNo068
1093x38 4x53 12.58225.415NoNo078
1103x38 4x50 12.971211.745NoNo079
1114x46 4x50 13.36383.525NoNo079
1122x45 4x46 27.33043.87NoNo097
1132x45 3x42 27.51693.26NoNo098
1142x46 3x42 27.70515.255YesNo098
1154x56 5x42 10.84447.97YesYes254
1164x52 4x56 12.98672.98NoYes045
1174x51 4x52 13.38450.8NoNo044
1184x47 4x51 13.58460.8NoNo034
1194x46 4x47 13.78561.54NoNo073
120E2.Q261 E2x52 11.92412.66YesNo025
1215x39 E2x52 12.57472.82YesNo075
122b.b2x5 b.l4x1 11.4136.795YesNo375
123b.b2x3 b.b2x5 14.58332.91YesYes367
124G.H3.18 G.S4.02 38.290510.045YesYes198
125G.S1.07 G.S4.02 35.54274.28YesYes198
126G.H2.07 b.l9x6 23.20534.34YesYes198
127G.H2.08 G.H3.18 44.8073.765NoYes189
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
6x55Lig22.712NoYes6010
6x58Lig11.2550NoYes4010
E2.M245Lig13.992NoYes0010
E3.Q352Lig11.1252NoYes0010
6x62Lig6.022NoYes2010
7x23Lig8.7352YesYes5010
E2.Y247Lig26.472NoYes0010
7x27Lig12.2352NoYes3010
E2.I254Lig11.3352NoYes0010
1x25Lig8.9152NoYes4010
E2.L252Lig4.3852NoYes0010
7x31Lig6.732NoYes3010
7x34Lig14.672NoYes4010
E2x51Lig3.9052NoYes4010
E1.E165Lig5.2050NoYes0010
2x60Lig6.3752YesYes7010
6x51Lig21.362NoYes6010
7x35Lig7.22YesYes3010
7x38Lig2.9452NoYes6010
2x59Lig4.4152NoYes6010
2x63Lig4.362NoYes5010
E1x50Lig4.6952YesYes9010
3x32Lig9.8552NoYes6010
3x33Lig9.282YesYes4010
5x43Lig6.262YesYes6010
6x48Lig4.6852YesYes8010
6x52Lig5.292YesYes8010
7x23NT.C903.482YesYes5012
7x24NT.C907.282NoYes8022
1x257x244.912NoNo4812
1x257x283.0952NoNo4312
1x271x322.912YesYes5612
1x272x643.572YesYes5412
1x277x314.9952YesNo5311
1x322x644.232YesYes6422
1x352x643.432NoYes5422
1x357x355.232NoYes5321
2x532x5610.7152YesYes8622
2x533x364.1552YesNo8722
2x536x483.1752YesYes8821
2x562x605.3852YesYes6721
2x563x3213.7052YesNo6621
2x592x604.252NoYes6711
2x607x387.082YesNo7611
2x63E1x507.542NoYes5911
2x647x3514.6552YesYes4321
E1x49E1x518.8552NoNo5212
E1x49E2.R2535.9552NoNo5012
3x25E1x507.8352NoYes9921
E1x50E2x5010.452YesNo9912
3x25E2x507.282NoNo9922
3x323x337.462NoYes6411
3x334x6112.152YesYes4512
3x335x432.822YesYes4611
3x335x4613.5852YesYes4612
3x365x4616.312NoYes7622
3x366x485.522NoYes7821
4x615x3910.82YesYes5722
E2.K248E2.Y24711.940NoNo0021
E2.L252E2.S2504.5052NoNo0012
E2.I254E2x514.9952NoNo0411
5x395x439.1652YesYes7621
5x406x557.740YesNo5621
5x425x433.422YesYes4621
5x435x4613.5152YesYes6612
5x445x478.5752YesYes6822
5x446x528.4852YesYes6821
5x476x529.6152YesYes8821
6x446x485.012NoYes9821
6x447x459.672NoNo9922
6x486x514.5552YesNo8611
6x486x524.2352YesYes8811
6x487x419.0752YesNo8812
6x487x456.2152YesNo8912
6x517x342.712NoNo6411
6x547x3410.310NoNo5421
6x627x238.232NoYes2511
6x627x273.5152NoNo2311
7x317x355.2752NoYes3311
1x27Lig2.8552YesYes5010
1x277x354.232YesYes5311
2x567x384.22YesNo6621
E2.M245E2.Y2472.9952NoNo0011
7x23E3.Q3528.1752YesNo5011
E1x49Lig2.522NoYes5010
E2.D246Lig1.3852NoYes0010
E2.D246E2.G2490.842NoNo0012

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
96.15Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
92.31Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
85.71Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
79.31Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
78.57Consensusendothelin_onOrthosteric Ligandetb_on eta_on
74.07Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
72.41Single6IGLIRL16206IGL-ETB-IRL1620
72.41Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
72.41Single8IY6Endothelin-18IY6-ETB-Endothelin-1
70.97Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
70.00Single5GLHEndothelin-15GLH-ETB-Endothelin-1
65.52Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
64.52Single6IGKEndothelin-36IGK-ETB-Endothelin-3
62.07Single8ZRTET-18ZRT-ETB-ET-1
58.06Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
58.06Single9KDFRES-701-39KDF-ETB-RES-701-3
54.84Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
53.33Single6JODAngiotensin II6JOD-AT2-Angiotensin II
53.33Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
53.12Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
53.12Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
51.72Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
51.61Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
51.61Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
51.61Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
50.00Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
48.39Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
46.88Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
46.67Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
45.71Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
45.45Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
45.16Single6PT2KGCHM076PT2-δ-KGCHM07
45.16Consensusangiotensin_onOrthosteric Ligandat1_on
45.16Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
44.12Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
44.12Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
44.12Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
43.75Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
43.75Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
43.75Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
43.75Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
43.75Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
43.75Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
43.75Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
43.75Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
43.75Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
43.33Single8WDTphotoNECA8WDT-A2A-photoNECA
42.86Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
42.86Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
42.86Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
42.86Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
42.86Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
42.86Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
42.86Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
42.86Consensusbradykinin_onOrthosteric Ligandbk2_on
42.86Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
42.86Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
42.42Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
42.42Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
42.42Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
42.42Single9JFYhNPSF9JFY-NPFF2-hNPSF-Gi1/β1/γ2
42.42Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
41.94Single3QAKUK-4320973QAK-A2A-UK-432097
41.94Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
41.94Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
41.94Single9IQSMuscarinic toxin 39IQS-M4-Muscarinic toxin 3
41.94Single9KFIRelaxin-39KFI-RXFP3-Relaxin-3-Gi2/β1/γ2
41.94Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
41.94Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
41.67Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
41.38Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
41.38Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
41.38Single7EZCUKA7EZC-A2A-UKA
41.38Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
41.18Single9KFKRelaxin-39KFK-RXFP4-Relaxin-3-Gi2/β1/γ2
41.18Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
41.18Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
41.18Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
41.18Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
41.18Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
40.62Single5WF5UK-4320975WF5-A2A-UK-432097
40.62Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
40.62Single9U4WGonadoliberin-19U4W-GnRH1-Gonadoliberin-1-chim(NtGi1L-Gs-CtGq)/β1/γ2
40.62Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
40.62Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
40.54Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
40.00Single5WF6UK-4320975WF6-A2A-UK-432097
40.00Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
40.00Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
40.00Single8Y72Peptide8Y72-μ-Peptide-BMS-986122-Gi1/β1/γ2
40.00Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
40.00Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
40.00Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
39.39Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
39.39Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
39.29Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
39.29Single6OS1TRV0266OS1-AT1-TRV026
39.29Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
38.89Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
38.71Single4IARErgotamine4IAR-5-HT1B-Ergotamine
38.71Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
38.71Single7F8XNN90567F8X-CCKA-NN9056
38.71Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
38.71Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
38.71Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
38.71Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
38.71Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
38.71Single9BUYLM1899BUY-β2-LM189-Gi1/β1/γ2
38.71Single9HB3Mambaquaretin-19HB3-V2-Mambaquaretin-1
38.71Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
38.71Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
38.71Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
38.71Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
38.71Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
38.46Single7T94LY21196207T94-M2-Acetylcholine-LY2119620-chim(NtGi1-Go)/β1/γ2
38.24Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
38.24Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
38.24Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
38.24Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
38.24Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
38.24Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
38.24Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
38.24Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
37.93Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
37.93Single6MXTSalmeterol6MXT-β2-Salmeterol
37.93Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
37.93Single8JJLOlodaterol8JJL-β2-Olodaterol
37.93Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
37.93Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
37.93Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
37.93Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
37.93Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
37.93Consensuslpa_offOrthosteric Ligandlpa1_off
37.93Consensuslpl_offOrthosteric Ligands1p_off lpa_off
37.93Consensusorexin_onOrthosteric Ligandox2_on
37.84Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
37.84Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
37.84Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
37.84Consensusbombesin_onOrthosteric Ligandbb2_on
37.84Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
37.84Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
37.50Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
37.50Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
37.50Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
37.50Single9IQRMuscarinic toxin 39IQR-α2a-Muscarinic toxin 3
37.50Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
37.50Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
37.50Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
37.50Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
37.50Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
37.14Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
37.14Single7SK3CXCL127SK3-ACKR3-CXCL12
36.67Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
36.67Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
36.67Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
36.67Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
36.67Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
36.67Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
36.67Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
36.36Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
36.36Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
36.36Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
36.36Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
36.36Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
36.36Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
36.36Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
36.36Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
36.36Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
36.36Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
36.36Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
36.36Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
36.11Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
36.11Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
35.71Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
35.71Single5IUAQ274563485IUA-A2A-Q27456348-Na
35.71Single5N2RPSB-365N2R-A2A-PSB-36-Na
35.71Single5N2SPSB365N2S-A1-PSB36
35.71Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
35.71Single6D26Fevipiprant6D26-DP2-Fevipiprant
35.71Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
35.71Single6S0QZM-2413856S0Q-A2A-ZM-241385
35.71Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
35.71Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
35.71Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
35.71Single8GNEKW-63568GNE-A2A-KW-6356-Na
35.71Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
35.71Consensusadenosine_offOrthosteric Liganda1_off a2_off
35.71Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
35.71Consensusdp_offOrthosteric Liganddp2_off
35.48Single4UG2CGS216804UG2-A2A-CGS21680
35.48Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
35.48Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
35.48Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
35.48Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
35.48Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
35.48Single8QJ2pN1628QJ2-MC4-pN162-Gs
35.48Single8X5YAstemizole8X5Y-H1-Astemizole
35.48Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
35.48Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
35.48Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
35.48Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
35.48Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
35.29Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
35.29Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
35.29Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
35.29Single8ZBISomatostatin-148ZBI-SST3-Somatostatin-14-Gi1/β1/γ2
35.29Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
35.29Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
35.00Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
34.62Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
34.48Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
34.48Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
34.48Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
34.48Single7PX4PSB-21137PX4-A2A-PSB-2113
34.48Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
34.48Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
34.48Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
34.48Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
34.48Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
34.48Single8XVLZibotentan8XVL-ETA-Zibotentan
34.48Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
34.38Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
34.38Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
34.38Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
34.38Single8ZBJSomatostatin-148ZBJ-SST5-Somatostatin-14-Gi1/β1/γ2
34.38Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
34.38Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
34.38Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
34.38Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
34.38Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
34.38Consensuslpl_onOrthosteric Ligands1p_on lpa_on
34.38Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
34.38Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
34.38Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
34.29Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
34.29Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
34.29Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
34.29Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
34.29Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
34.21Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
34.21Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
34.21Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
33.33Single4RWADIPP-NH24RWA-δ-DIPP-NH2
33.33Single4XT3Fractalkine4XT3-US28-Fractalkine
33.33Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
33.33Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
33.33Single6A93Risperidone6A93-5-HT2A-Risperidone
33.33Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
33.33Single6OS2TRV0266OS2-AT1-TRV026
33.33Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
33.33Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
33.33Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
33.33Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
33.33Single7F61PF-036547467F61-H3-PF-03654746
33.33Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single7T32ZM-2413857T32-A2A-ZM-241385
33.33Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
33.33Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
33.33Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
33.33Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
33.33Single7YITNalfurafine7YIT-κ-Nalfurafine
33.33Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
33.33Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
33.33Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
33.33Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
33.33Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
33.33Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
33.33Single9E82SDF-1-beta9E82-ACKR3-SDF-1-β-Arrestin2
33.33Single9IQVMuscarinic toxin 39IQV-Alpha1A-Muscarinic toxin 3
33.33Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
33.33Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
33.33Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
33.33Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
33.33Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
33.33Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
33.33Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
33.33Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
33.33Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
33.33Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
33.33Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
33.33Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
33.33Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
33.33Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
32.50Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
32.43Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
32.43Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
32.43Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
32.43Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
32.43Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
32.35Single3OE0CVX153OE0-CXCR4-CVX15
32.35Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
32.35Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
32.35Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
32.35Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
32.35Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
32.35Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
32.35Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
32.35Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
32.35Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
32.35Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
32.35Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
32.26Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
32.26Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
32.26Single6IBLArformoterol6IBL-β1-Arformoterol
32.26Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
32.26Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
32.26Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
32.26Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
32.26Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
32.26Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
32.26Single8ZPLHF511168ZPL-CXCR4-HF51116
32.26Single8ZWGJR14a8ZWG-C3aB-JR14a-Gi1/β1/γ2
32.26Single9M54Neuropeptide VF9M54-NPFF2-Neuropeptide VF-Gi1/β1/γ2
32.26Consensuscck_onOrthosteric Ligandccka_on cckb_on
32.26Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
32.26Consensusendothelin_offOrthosteric Ligandetb_off
32.26Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
32.26Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
32.26Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
32.26Consensusprostanoid_offOrthosteric Ligandep_off dp_off
32.14Single3EMLZM-2413853EML-A2A-ZM-241385
32.14Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
32.14Single5IU8Q274563475IU8-A2A-Q27456347-Na
32.14Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
32.14Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
32.14Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
32.14Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
32.14Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
32.14Single6S0LZM-2413856S0L-A2A-ZM-241385
32.14Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
32.14Single7PYRPSB-21157PYR-A2A-PSB-2115
32.14Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
32.14Single8CU6LJ-45178CU6-A2A-LJ-4517
32.14Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
32.14Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
32.14Single9CHXS-Carazolol9CHX-β2-S-Carazolol
32.14Single9H37A1IR09H37-A2A-A1IR0-Na
32.14Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
32.14Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
31.58Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
31.43Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
31.43Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
31.43Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
31.43Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
31.43Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
31.43Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
31.43Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
31.43Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
31.43Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
31.43Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
31.43Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
31.43Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
31.43Consensusvasop-oxy_onOrthosteric Ligandv2_on
31.43Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
31.25Single3NY9ICI118-5513NY9-β2-ICI118-551
31.25Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
31.25Single6PT3DPI-2876PT3-δ-DPI-287
31.25Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
31.25Single7SK9CCX6627SK9-ACKR3-CCX662
31.25Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
31.25Single7XN9L-054,5227XN9-SST2-L-054,522
31.25Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
31.25Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
31.25Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
31.25Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
31.25Single8XQJJN2418XQJ-Apelin-JN241
31.25Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
31.25Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
31.25Single9CGKC5-Quino9CGK-δ-C5-Quino-Gi1/β1/γ2
31.25Single9IPVJR14a9IPV-C3aB-JR14a-Gi1/β1/γ2
31.25Single9M0RNeuropeptide VF9M0R-NPFF1-Neuropeptide VF-Gi1/β1/γ2
31.25Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
31.25Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
31.25Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
31.03Single5C1MBU725C1M-μ-BU72
31.03Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
31.03Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
31.03Single7C61Ergotamine7C61-5-HT1B-Ergotamine
31.03Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
31.03Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
31.03Single8QOTNanobody-E8QOT-μ-Nanobody-E
31.03Single8S4DCMF-0198S4D-Apelin-CMF-019
31.03Single8TF5Oleic acid8TF5-GPR6-Oleic acid
31.03Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
31.03Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
31.03Single9EHSLUF76029EHS-A3A-LUF7602
31.03Single9F34FOB02-04A9F34-D3-FOB02-04A-Go/β1/γ2
31.03Single9I52A1IZU9I52-D1-A1IZU-Gs/β1/γ2
31.03Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
31.03Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
30.77Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
30.77Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
30.56Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
30.56Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
30.56Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
30.30Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
30.30Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
30.30Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
30.30Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
30.30Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
30.30Single8PKMBefiradol8PKM-5-HT1A-Befiradol-Gi1/β1/γ1
30.30Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
30.30Single8XWNCXCL88XWN-CXCR2-CXCL8
30.30Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
30.30Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
30.30Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
30.30Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
30.30Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
30.30Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
30.00Single2YDVNECA2YDV-A2A-NECA
30.00Single3P0GBI1671073P0G-β2-BI167107
30.00Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
30.00Single4UHRCGS216804UHR-A2A-CGS21680
30.00Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
30.00Single5G53NECA5G53-A2A-NECA-Gs
30.00Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
30.00Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
30.00Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
30.00Single7TUYGSK682753A7TUY-GPR183-GSK682753A
30.00Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
30.00Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
30.00Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
30.00Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
30.00Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
30.00Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
30.00Single8E0GBU728E0G-μ-BU72
30.00Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
30.00Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
30.00Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
30.00Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
30.00Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
30.00Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
30.00Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
30.00Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
30.00Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
30.00Single8Y73Peptide8Y73-μ-Peptide-MPAM-15-Gi1/β1/γ2
30.00Single8ZWFJR14a8ZWF-C3aB-JR14a
30.00Single9BJKNaloxone9BJK-μ-Naloxone-NAM
30.00Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
30.00Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
30.00Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
30.00Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
30.00Consensuslpa_onOrthosteric Ligandlpa1_on
30.00Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
30.00Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
29.73Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
29.73Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
29.63Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
29.63Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
29.63Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
29.63Single7F8ULintitript7F8U-CCKA-Lintitript
29.63Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
29.63Single8GNGIstradefylline8GNG-A2A-Istradefylline
29.63Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
29.63Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
29.63Single8U4PAMD31008U4P-CXCR4-AMD3100-Gi1/β1/γ2
29.63Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
29.63Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
29.41Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
29.41Single7SK5CXCL127SK5-ACKR3-CXCL12
29.41Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
29.41Single9IK8SST analogue9IK8-SST1-SST analogue-Gi1/β1/γ2
29.41Single9J0FNADH9J0F-P2Y14-NADH-Gi1/β1/γ2
29.41Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
29.41Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
29.17Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
29.03Single4AMIBucindolol4AMI-β1-Bucindolol
29.03Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
29.03Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
29.03Single6CM4Risperidone6CM4-D2-Risperidone
29.03Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
29.03Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
29.03Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
29.03Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
29.03Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
29.03Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
29.03Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
29.03Single8JJ8Formoterol8JJ8-β2-Formoterol
29.03Single8JWY2-1188JWY-A2A-2-118
29.03Single8JWZAB9288JWZ-A2A-AB928-Na
29.03Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
29.03Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
29.03Single9M4QDoxazosin9M4Q-Alpha1A-Doxazosin
29.03Consensusalpha1_offOrthosteric Ligandalpha1a_off
29.03Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
29.03Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
29.03Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
29.03Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
29.03Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
29.03Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
29.03Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
29.03Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
29.03Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
29.03Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
29.03Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
29.03Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
29.03Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
29.03Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
29.03Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
29.03Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
29.03Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
29.03Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
29.03Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
28.95Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
28.95Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
28.57Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
28.57Single5IU7Q274563465IU7-A2A-Q27456346-Na
28.57Single5IUBQ274563445IUB-A2A-Q27456344-Na
28.57Single5JTBZM-2413855JTB-A2A-ZM-241385
28.57Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
28.57Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
28.57Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
28.57Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
28.57Single5UVIZM-2413855UVI-A2A-ZM-241385
28.57Single6AQFZM-2413856AQF-A2A-ZM-241385
28.57Single6IQLL7458706IQL-D4-L745870
28.57Single6MH8ZM-2413856MH8-A2A-ZM-241385
28.57Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
28.57Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
28.57Single7AROLUF58337ARO-A2A-LUF5833-Na
28.57Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
28.57Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
28.57Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
28.57Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
28.57Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
28.57Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
28.57Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
28.57Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
28.57Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
28.57Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
28.57Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
28.57Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
28.57Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
28.57Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
28.57Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
28.57Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
28.57Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
28.57Single8ZPMAMD0708ZPM-CXCR4-AMD070
28.57Single8ZPNAMD31008ZPN-CXCR4-AMD3100
28.57Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
28.57Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
28.57Single9JH3CMF-0199JH3-Apelin-CMF-019-Gi1/β1/γ2
28.57Single9JMDAzithromycin9JMD-Motilin-Azithromycin-chim(Gs-CtGq)/β1/γ2
28.57Single9M1OMorphine-Modulating Neuropeptide B9M1O-NPFF2-Morphine-Modulating Neuropeptide B-Gi1/β1/γ2
28.57Consensusa2_offOrthosteric Liganda2a_off
28.57Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
28.57Consensusalpha1_onOrthosteric Ligandalpha1a_on
28.57Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
28.57Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
28.57Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
28.57Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
28.57Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
28.57Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
28.21Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
28.21Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
28.12Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
28.12Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
28.12Single5X93K-87945X93-ETB-K-8794
28.12Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
28.12Single6H7LDobutamine6H7L-β1-Dobutamine
28.12Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
28.12Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
28.12Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
28.12Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
28.12Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
28.12Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
28.12Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
28.12Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
28.12Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
28.12Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
28.12Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
28.12Single8XVUCXCL28XVU-CXCR2-CXCL2
28.12Single8XWFCXCL38XWF-CXCR2-CXCL3
28.12Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
28.12Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
28.12Single9CGJC6-Quino9CGJ-δ-C6-Quino-Gi1/β1/γ2
28.12Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
28.12Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
28.12Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
28.12Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
28.12Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
28.12Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
28.12Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
28.12Consensuschemerin_onOrthosteric Ligandcml1_on
28.12Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
28.12Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
28.12Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
28.12Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
28.12Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
27.78Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
27.78Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
27.78Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
27.59Single2Y02Carmoterol2Y02-β1-Carmoterol
27.59Single3NY8ICI118-5513NY8-β2-ICI118-551
27.59Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
27.59Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
27.59Single4EJ4Naltrindole4EJ4-δ-Naltrindole
27.59Single4GBRS-Carazolol4GBR-β2-S-Carazolol
27.59Single5DHHSB-6121115DHH-NOP-SB-612111
27.59Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
27.59Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
27.59Single5UIGCmpd-15UIG-A2A-Cmpd-1
27.59Single6D27CAY104716D27-DP2-CAY10471
27.59Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
27.59Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
27.59Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
27.59Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
27.59Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
27.59Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
27.59Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
27.59Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
27.59Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
27.59Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
27.59Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
27.59Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
27.59Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
27.59Single8JXRLSD8JXR-D1-LSD
27.59Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
27.59Single8T1WCVN4248T1W-GPR6-CVN424
27.59Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.59Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.59Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.59Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
27.59Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
27.59Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
27.59Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
27.59Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
27.59Single9KFJPubChem 1383196749KFJ-RXFP3-PubChem 138319674-Gi2/β1/γ2
27.59Single9PLNN-(5-methylnaphthalen-1-yl)pyridin-4-amine9PLN-α2a-N-(5-methylnaphthalen-1-yl)pyridin-4-amine
27.59Single9PLON-(5-methylnaphthalen-1-yl)pyridin-4-amine9PLO-α2a-N-(5-methylnaphthalen-1-yl)pyridin-4-amine-Go/β1/γ2
27.59Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
27.59Consensuscck_offOrthosteric Ligandccka_off
27.59Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
27.59Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
27.59Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
27.59Consensusdopamine_offOrthosteric Ligandd2_off d3_off
27.59Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
27.59Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
27.59Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
27.59Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
27.27Single5ZTYAM102575ZTY-CB2-AM10257
27.27Single6KNMJN241-96KNM-Apelin-JN241-9
27.27Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
27.27Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
27.27Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
27.27Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
27.27Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
27.27Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
27.27Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
27.27Single9IPYJR14a9IPY-C3aB-JR14a
27.27Single9V2NMacimorelin9V2N-Ghrelin-Macimorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
27.27Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
27.27Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
27.27Consensuskisspeptin_onOrthosteric Ligandkiss1_on
27.27Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
27.27Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
27.03Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
27.03Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
27.03Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
27.03Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
27.03Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
27.03Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
27.03Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
26.92Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/β1/γ2
26.67Single2RH1S-Carazolol2RH1-β2-S-Carazolol
26.67Single2Y00Dobutamine2Y00-β1-Dobutamine
26.67Single2YCWS-Carazolol2YCW-β1-S-Carazolol
26.67Single5D6LS-Carazolol5D6L-β2-S-Carazolol
26.67Single5X7DS-Carazolol5X7D-β2-S-Carazolol-Cmpd-15
26.67Single5XPRBosentan5XPR-ETB-Bosentan
26.67Single6E67BI1671076E67-β2-BI167107-Gs(CT)
26.67Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
26.67Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
26.67Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
26.67Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
26.67Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
26.67Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
26.67Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
26.67Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
26.67Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
26.67Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
26.67Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.67Single8JXSPF-61428JXS-D1-PF-6142
26.67Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.67Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.67Single8ZYTNeurotensin peptide 8-138ZYT-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
26.67Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
26.67Single9K07DSO-5a9K07-BB3-DSO-5a-chim(NtGi2L-Gs-CtGq)/β1/γ2
26.67Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
26.67Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
26.67Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
26.67Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
26.67Consensusamine_offonOrthosteric Ligandamine_off amine_on
26.67Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
26.67Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
26.67Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
26.67Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
26.67Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
26.67Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
26.67Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
26.67Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
26.67Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
26.67Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
26.67Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
26.67Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
26.67Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
26.67Consensustrace-amine_onOrthosteric Ligandta1_on
26.47Single4XT1Fractalkine4XT1-US28-Fractalkine
26.47Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
26.47Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
26.47Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
26.47Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
26.47Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
26.47Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
26.47Single8U4OCXCL128U4O-CXCR4-CXCL12-Gi1/β1/γ2
26.47Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
26.47Single9J0IUDP-Glucuronic acid9J0I-P2Y14-UDP-Glucuronic acid-Gi1/β1/γ2
26.47Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
26.19Consensuscrf_on_gpOrthosteric Ligandcrf2_on_gp crf1_on_gp
25.93Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
25.93Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
25.93Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
25.93Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
25.93Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
25.93Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
25.93Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
25.81Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
25.81Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
25.81Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
25.81Single5D5AS-Carazolol5D5A-β2-S-Carazolol
25.81Single5D5BS-Carazolol5D5B-β2-S-Carazolol
25.81Single6J21Aprepitant6J21-NK1-Aprepitant
25.81Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
25.81Single6TQ7SB-3348676TQ7-OX1-SB-334867
25.81Single6WGTLSD6WGT-5-HT2A-LSD
25.81Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
25.81Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
25.81Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
25.81Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
25.81Single7FEECP559407FEE-CB1-CP55940-ZCZ011
25.81Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
25.81Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
25.81Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
25.81Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
25.81Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
25.81Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
25.81Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
25.81Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
25.81Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
25.81Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
25.81Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
25.81Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
25.81Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
25.81Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
25.81Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
25.81Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
25.81Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
25.81Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
25.81Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
25.81Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
25.81Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
25.81Single9I54A1IZV9I54-D1-A1IZV-Gs/β1/γ2
25.81Single9IK9SST analogue9IK9-SST1-SST analogue-Gi1/β1/γ2
25.81Single9JMCDS-3801b9JMC-Motilin-DS-3801b-chim(Gs-CtGq)/β1/γ2
25.81Single9UY3Anamorelin9UY3-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
25.81Consensusa2_onOrthosteric Liganda2b_on
25.81Consensusa2_on_gpOrthosteric Liganda2b_on_gp
25.81Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
25.81Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
25.81Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
25.81Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
25.81Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
25.81Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
25.81Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
25.81Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
25.81Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
25.81Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
25.81Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
25.81Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
25.81Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
25.81Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
25.81Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
25.81Consensusneurotensin_onOrthosteric Ligandnts1_on
25.81Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
25.81Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
25.81Consensusrelaxin_onOrthosteric Ligandrxfp4_on
25.81Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
25.81Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
25.81Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
25.71Single6HLOAprepitant6HLO-NK1-Aprepitant
25.71Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
25.71Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
25.71Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
25.71Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
25.64Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
25.64Single8W8WAlpha-MSH8W8W-MC3-α-MSH-Ca-Gs/β1/γ2
25.64Single8W8XBeta-MSH8W8X-MC3-β-MSH-Ca-Gs/β1/γ2
25.58Consensusclass-a_class-b1_cons_on_gpOrthosteric Ligandclass-a_on_gp class-b1_on_gp
25.00Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
25.00Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
25.00Single3D4STimolol3D4S-β2-Timolol
25.00Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
25.00Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
25.00Single4LDEBI1671074LDE-β2-BI167107
25.00Single4XEENeurotensin4XEE-NTS1-Neurotensin
25.00Single4XESNeurotensin4XES-NTS1-Neurotensin
25.00Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
25.00Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
25.00Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
25.00Single6AKXA4R6AKX-CCR5-A4R
25.00Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
25.00Single6DS0Ly2660976DS0-5-HT2B-Ly266097
25.00Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
25.00Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
25.00Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
25.00Single6KQICP559406KQI-CB1-CP55940-Org27569
25.00Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
25.00Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
25.00Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
25.00Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
25.00Single6ZG4HTL00099366ZG4-M1-HTL0009936
25.00Single7DFPSpiperone7DFP-D2-Spiperone
25.00Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
25.00Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
25.00Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
25.00Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
25.00Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
25.00Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
25.00Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
25.00Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
25.00Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
25.00Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
25.00Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
25.00Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
25.00Single7XRRLemborexant7XRR-OX2-Lemborexant
25.00Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
25.00Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
25.00Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
25.00Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
25.00Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
25.00Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
25.00Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
25.00Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
25.00Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
25.00Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
25.00Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
25.00Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
25.00Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
25.00Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
25.00Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
25.00Single8XQJJN2418XQJ-Apelin-JN241
25.00Single8XWACXCL18XWA-CXCR2-CXCL1
25.00Single8XWMCXCL68XWM-CXCR2-CXCL6
25.00Single8XWSCXCL58XWS-CXCR2-CXCL5
25.00Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
25.00Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
25.00Single8YYWAlpha-ketoglutarate8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
25.00Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
25.00Single9H2XA1IR19H2X-A2A-A1IR1-Na
25.00Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
25.00Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
25.00Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
25.00Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
25.00Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
25.00Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
25.00Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
25.00Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
25.00Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
25.00Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
24.39Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
24.39Consensusclass-a_class-b1_cons_onOrthosteric Ligandclass-a_on class-b1_on
24.32Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
24.32Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
24.32Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
24.32Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
24.24Single4BUONeurotensin4BUO-NTS1-Neurotensin
24.24Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
24.24Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
24.24Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
24.24Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
24.24Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
24.24Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
24.24Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-SBI-553-chim(NtGi1-Go)/β1/γ2
24.24Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
24.24Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
24.24Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
24.24Single8JPFNeurotensin8JPF-NTS1-Neurotensin-SBI-553
24.24Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
24.24Single8S2TIsoprenaline8S2T-β1-Isoprenaline-chim(NtGi1-Gs)/β1/γ2
24.24Single8T3OTUG-8918T3O-FFA4-TUG-891-chim(NtGi2L-Gs-CtGq)/β1/γ2
24.24Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
24.24Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
24.24Single9DYEBuspirone9DYE-5-HT1A-Buspirone-Go/β1/γ2
24.24Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
24.14Single3REYXAC3REY-A2A-XAC
24.14Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
24.14Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
24.14Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
24.14Single4MBSMaraviroc4MBS-CCR5-Maraviroc
24.14Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
24.14Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
24.14Single6KUXRS-799486KUX-α2a-RS-79948
24.14Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
24.14Single6PS0S-Carazolol6PS0-β2-S-Carazolol
24.14Single6PS4ICI118-5516PS4-β2-ICI118-551
24.14Single6PS5S-Propranolol6PS5-β2-S-Propranolol
24.14Single6TPGEMPA6TPG-OX2-EMPA
24.14Single6TPNHTL66416TPN-OX2-HTL6641
24.14Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
24.14Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
24.14Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
24.14Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
24.14Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
24.14Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
24.14Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
24.14Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
24.14Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
24.14Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
24.14Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
24.14Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
24.14Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
24.14Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
24.14Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
24.14Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
24.14Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
24.14Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
24.14Single8RLNLUF58348RLN-A2A-LUF5834
24.14Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
24.14Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
24.14Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
24.14Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
24.14Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
24.14Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
24.14Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
24.14Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
24.14Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
24.14Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
24.14Single8Y6YGLPG09748Y6Y-FFA2-GLPG0974
24.14Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
24.14Single9JFUNE52-QQ579JFU-GPR4-NE52-QQ57
24.14Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
24.14Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
24.14Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
24.14Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
24.14Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
24.14Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
24.14Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
24.14Consensusgrh_offOrthosteric Ligandgnrh1_off
23.68Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
23.68Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
23.68Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
23.68Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
23.53Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
23.53Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
23.53Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
23.53Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
23.53Single9IZASCH9002719IZA-HCA2-SCH900271-Gi1/β1/γ2
23.53Single9MD1Buspirone9MD1-5-HT1A-Buspirone-Gz/β1/γ2
23.33Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
23.33Single2Y01Dobutamine2Y01-β1-Dobutamine
23.33Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
23.33Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
23.33Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
23.33Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
23.33Single4QIMANTA XV4QIM-SMO-ANTA XV
23.33Single5DHGC-355DHG-NOP-C-35
23.33Single5UENDU1725UEN-A1-DU172
23.33Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
23.33Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
23.33Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
23.33Single6PS1Timolol6PS1-β2-Timolol
23.33Single6TOTLemborexant6TOT-OX1-Lemborexant
23.33Single6XBM5LWE6XBM-SMO-5LWE-Gi1/β1/γ2
23.33Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
23.33Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
23.33Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
23.33Single7BU7BI1671077BU7-β1-BI167107
23.33Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
23.33Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
23.33Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
23.33Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
23.33Single7UL4Alvimopan7UL4-μ-Alvimopan
23.33Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
23.33Single7V3ZCP559407V3Z-CB1-CP55940
23.33Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
23.33Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
23.33Single7WC7Lisuride7WC7-5-HT2A-Lisuride
23.33Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
23.33Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
23.33Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
23.33Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
23.33Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
23.33Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
23.33Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
23.33Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
23.33Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
23.33Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
23.33Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.33Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.33Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.33Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.33Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.33Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.33Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.33Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.33Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.33Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.33Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
23.33Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
23.33Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
23.33Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
23.33Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
23.33Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
23.33Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
23.33Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
23.33Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
23.33Single8JJOAlprenolol8JJO-β2-Alprenolol
23.33Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
23.33Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
23.33Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
23.33Single8PJKST1718PJK-5-HT1A-ST171-Gi1/β1/γ1
23.33Single8TH3AT118-H Nanobody8TH3-AT1-AT118-H Nanobody
23.33Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
23.33Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.33Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.33Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.33Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.33Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
23.33Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
23.33Single8X63Mepyramine8X63-H1-Mepyramine
23.33Single8X64Desloratadine8X64-H1-Desloratadine
23.33Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
23.33Single8ZYYNeurotensin peptide 8-138ZYY-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
23.33Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
23.33Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
23.33Single9PQD(6m)-1-methyl-6-(1,2,5,6-tetrahydropyridin-3-yl)-1h-indole9PQD-α2a-(6m)-1-methyl-6-(1,2,5,6-tetrahydropyridin-3-yl)-1h-indole
23.33Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
23.33Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
23.33Consensus5ht5_onOrthosteric Ligand5ht5a_on
23.33Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
23.33Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
23.33Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
23.33Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
23.33Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
23.33Consensusa3_onOrthosteric Liganda3a_on
23.33Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
23.33Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
23.33Consensusalpha2_onOrthosteric Ligandalpha2b_on
23.33Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
23.33Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
23.33Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
23.33Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
23.33Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
23.33Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
23.33Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
23.33Consensushistamine_offOrthosteric Ligandh1_off
23.33Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
23.08Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
23.08Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
23.08Consensuspac_on_gpOrthosteric Ligandpac1_on_gp
22.86Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
22.86Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
22.86Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
22.86Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
22.86Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
22.86Single8WKYPG-9348WKY-MC4-PG-934
22.86Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
22.86Single9M4TSilodosin9M4T-Alpha1A-Silodosin
22.86Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
22.86Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
22.58Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
22.58Single5JQHS-Carazolol5JQH-β2-S-Carazolol
22.58Single5TVNLSD5TVN-5-HT2B-LSD
22.58Single5WIUNemonapride5WIU-D4-Nemonapride
22.58Single5WIVNemonapride5WIV-D4-Nemonapride-Na
22.58Single5WQCEMPA5WQC-OX2-EMPA
22.58Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
22.58Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
22.58Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
22.58Single6HLPNetupitant6HLP-NK1-Netupitant
22.58Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
22.58Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
22.58Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
22.58Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
22.58Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
22.58Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
22.58Single6PS6Timolol6PS6-β2-Timolol
22.58Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
22.58Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
22.58Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
22.58Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
22.58Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
22.58Single7LD3Adenosine7LD3-A1-Adenosine-MIPS521-Gi2/β1/γ2
22.58Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
22.58Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
22.58Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
22.58Single7W41PD1762527W41-BB2-PD176252
22.58Single7WC6LSD7WC6-5-HT2A-LSD
22.58Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
22.58Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.58Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
22.58Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
22.58Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
22.58Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
22.58Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
22.58Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
22.58Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
22.58Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
22.58Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
22.58Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
22.58Single9CIBFCH-22964139CIB-HCA2-FCH-2296413
22.58Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
22.58Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
22.58Single9EE8Adenosine9EE8-A2A-Adenosine-Gs/β1/γ2
22.58Single9F33FOB02-04A9F33-D3-FOB02-04A-Go/β1/γ2
22.58Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
22.58Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
22.58Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
22.58Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
22.58Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
22.58Consensusa3_on_gpOrthosteric Liganda3a_on_gp
22.58Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
22.58Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
22.58Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
22.58Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
22.58Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
22.58Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
22.58Consensusbombesin_offOrthosteric Ligandbb2_off
22.58Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
22.58Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
22.58Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
22.58Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
22.58Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
22.58Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
22.58Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
22.58Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
22.50Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
22.22Single3OE6IT1t3OE6-CXCR4-IT1t
22.22Single4XNWMRS25004XNW-P2Y1-MRS2500
22.22Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
22.22Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
22.22Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
22.22Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
22.22Single7WC5Psilocin7WC5-5-HT2A-Psilocin
22.22Single7XNACYN1548067XNA-SST2-CYN154806
22.22Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
22.22Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
22.22Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
22.22Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
22.22Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
22.22Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
22.22Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
22.22Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
22.22Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
21.95Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
21.95Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
21.95Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
21.95Consensusvip-pacap_onOrthosteric Ligandvpac_on pac_on
21.95Consensusvip-pacap_on_gpOrthosteric Ligandvpac_on_gp pac_on_gp
21.88Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
21.88Single4BV0Neurotensin4BV0-NTS1-Neurotensin
21.88Single4DJHJDTic4DJH-κ-JDTic
21.88Single4U15Tiotropium4U15-M3-Tiotropium
21.88Single5V56TC1145V56-SMO-TC114
21.88Single5XRAAM115425XRA-CB1-AM11542
21.88Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
21.88Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
21.88Single6H7JIsoprenaline6H7J-β1-Isoprenaline
21.88Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
21.88Single6OL9Tiotropium6OL9-M5-Tiotropium
21.88Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
21.88Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
21.88Single7B6WCyclazosin7B6W-α1b-Cyclazosin
21.88Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
21.88Single7F1TMIP-1a7F1T-CCR5-MIP-1a
21.88Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
21.88Single7R0CAVP7R0C-V2-AVP-Arrestin2
21.88Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
21.88Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
21.88Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
21.88Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.88Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
21.88Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
21.88Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.88Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
21.88Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
21.88Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
21.88Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
21.88Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
21.88Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
21.88Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
21.88Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
21.88Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
21.88Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
21.88Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
21.88Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
21.88Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
21.88Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
21.88Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
21.88Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
21.88Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
21.88Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
21.88Consensustachykinin_offOrthosteric Ligandnk1_off
21.62Single6W25SHU91196W25-MC4-SHU9119-Ca
21.62Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
21.62Single8W8YGamma-MSH8W8Y-MC3-γ-MSH-Ca-Gs/β1/γ2
21.43Single3OE9IT1t3OE9-CXCR4-IT1t
21.43Single3PBLEticlopride3PBL-D3-Eticlopride
21.43Single4O9RCyclopamine4O9R-SMO-Cyclopamine
21.43Single5L7IVismodegib5L7I-SMO-Vismodegib
21.43Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
21.43Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
21.43Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
21.43Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
21.43Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
21.43Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
21.43Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
21.43Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
21.43Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
21.43Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
21.43Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
21.43Single9IXJHistamine9IXJ-H2-Histamine-Gs/β1/γ2
21.43Single9LMPNE52-QQ579LMP-GPR4-NE52-QQ57
21.43Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
21.28Consensusclass-b1_onOrthosteric Ligandglucagon_on vip-pacap_on pth_on crf_on calcitonin_on
21.21Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
21.21Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
21.21Single5CXVTiotropium5CXV-M1-Tiotropium
21.21Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
21.21Single6YVRNTS8-136YVR-NTS1-NTS8-13
21.21Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
21.21Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
21.21Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
21.21Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
21.21Single7K15MKD0467K15-BLT1-MKD046-Na
21.21Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
21.21Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
21.21Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
21.21Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.21Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
21.21Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
21.21Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
21.21Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
21.21Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
21.21Single9EBIPiclidenoson9EBI-A3A-Piclidenoson-chim(NtGi1L-Gs-CtGi1)/β1/γ2
21.21Single9GL2Befiradol9GL2-5-HT1A-Befiradol-Gs/β1/γ2
21.21Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
21.21Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
21.21Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
21.21Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
21.21Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
21.21Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
21.21Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
21.05Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
21.05Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
21.05Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
21.05Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
20.69Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
20.69Single3ODUIT1t3ODU-CXCR4-IT1t
20.69Single3PWHZM-2413853PWH-A2A-ZM-241385
20.69Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
20.69Single4BWBNeurotensin4BWB-NTS1-Neurotensin
20.69Single4QINSAG1.54QIN-SMO-SAG1.5
20.69Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
20.69Single5WS3EMPA5WS3-OX2-EMPA
20.69Single6AKYMaraviroc6AKY-CCR5-Maraviroc
20.69Single6B73MP11046B73-κ-MP1104
20.69Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
20.69Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
20.69Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
20.69Single7BR3Elagolix7BR3-GnRH1-Elagolix
20.69Single7F8YDevazepide7F8Y-CCKA-Devazepide
20.69Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
20.69Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
20.69Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
20.69Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
20.69Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
20.69Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
20.69Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
20.69Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
20.69Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
20.69Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
20.69Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
20.69Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
20.69Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
20.69Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
20.69Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.69Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
20.69Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.69Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.69Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
20.69Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
20.69Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
20.69Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
20.69Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
20.69Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
20.69Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.69Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.69Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.69Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
20.69Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
20.69Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
20.69Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
20.69Single9EEAAdenosine9EEA-A2A-Adenosine-Gs/β1/γ2
20.69Single9LRBHistamine9LRB-H1-Histamine-Gs/β1/γ2
20.69Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
20.69Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
20.69Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
20.69Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
20.69Consensusalpha2_offOrthosteric Ligandalpha2c_off
20.69Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
20.69Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
20.69Consensusorexin_offOrthosteric Ligandox2_off ox1_off
20.69Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
20.69Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
20.69Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
20.59Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
20.59Single6K1QIRL25006K1Q-ETB-IRL2500
20.59Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
20.59Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
20.59Single7UM4AS26747237UM4-5-HT5A-AS2674723
20.59Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
20.59Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
20.59Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
20.59Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
20.59Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
20.59Single9AS02-bromo-LSD9AS0-5-HT2A-2-bromo-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
20.59Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
20.59Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
20.59Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
20.59Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
20.51Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
20.51Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
20.51Consensuspac_onOrthosteric Ligandpac1_on
20.00Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
20.00Single2YDOAdenosine2YDO-A2A-Adenosine
20.00Single3RZECidoxepin3RZE-H1-Cidoxepin
20.00Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
20.00Single4ZJCSB-6740424ZJC-OX1-SB-674042
20.00Single6A94Zotepine6A94-5-HT2A-Zotepine
20.00Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
20.00Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
20.00Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
20.00Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
20.00Single6V9SGTPL114036V9S-OX1-GTPL11403
20.00Single6VI4JDTic6VI4-κ-JDTic
20.00Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
20.00Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
20.00Single6ZG9GSK10347026ZG9-M1-GSK1034702
20.00Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
20.00Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
20.00Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
20.00Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
20.00Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
20.00Single7UL3Famotidine7UL3-H2-Famotidine
20.00Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
20.00Single7UTZDPPC7UTZ-TSH-TR1402-DPPC-Gs/β1/γ2
20.00Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
20.00Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
20.00Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
20.00Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
20.00Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
20.00Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
20.00Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
20.00Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
20.00Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
20.00Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
20.00Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
20.00Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
20.00Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
20.00Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
20.00Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
20.00Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
20.00Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
20.00Single8IHKAcifran8IHK-HCA3-Acifran
20.00Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
20.00Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
20.00Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
20.00Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
20.00Single8K9LDamgo8K9L-μ-Damgo-BMS-986122-Gi3/β1/γ1
20.00Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
20.00Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
20.00Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
20.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
20.00Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
20.00Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
20.00Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
20.00Single9ARXSerotonin9ARX-5-HT2A-Serotonin
20.00Single9AS5Mescaline9AS5-5-HT2A-Mescaline
20.00Single9AS6Mescaline9AS6-5-HT2A-Mescaline-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
20.00Single9BLWCagrilintide backbone (non-acylated)9BLW-CT (AMY1)-Cagrilintide backbone (non-acylated)-Gs/β1/γ2; RAMP1
20.00Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
20.00Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
20.00Single9K0KUTP9K0K-P2Y4-UTP-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single9K0XATP9K0X-P2Y2-ATP-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Gi1/β1/γ2
20.00Single9K20ATP9K20-P2Y2-ATP-chim(NtGi1-Go)/β1/γ2
20.00Single9KPDSA09KPD-TAS2R16-SA0-chim(Gs-CtGt3)/β1/γ2
20.00Single9M2FNeuropeptide FF9M2F-NPFF1-Neuropeptide FF-Gi1/β1/γ2
20.00Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
20.00Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
20.00Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
20.00Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
20.00Consensusopsins_offOrthosteric Ligandrhodopsin_off
20.00Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
20.00Consensussensory_offOrthosteric Ligandopsins_off
19.61Consensusclass-b1_on_gpOrthosteric Ligandglucagon_on_gp vip-pacap_on_gp pth_on_gp crf_on_gp calcitonin_on_gp
19.57Consensuspth_onOrthosteric Ligandpth1_on pth2_on
19.51Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
19.51Consensusglp_onOrthosteric Ligandglp1_on glp2_on
19.51Consensusglp_on_gpOrthosteric Ligandglp1_on_gp glp2_on_gp
19.51Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
19.44Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
19.44Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
19.44Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
19.44Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
19.44Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
19.44Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
19.44Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
19.44Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
19.44Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
19.44Consensussomatostatin_offOrthosteric Ligandsst2_off
19.35Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
19.35Single2Y04Salbutamol2Y04-β1-Salbutamol
19.35Single4DAJTiotropium4DAJ-M3-Tiotropium
19.35Single4MQSIperoxo4MQS-M2-Iperoxo
19.35Single4QKX35V4QKX-β2-35V
19.35Single4U14Tiotropium4U14-M3-Tiotropium
19.35Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
19.35Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
19.35Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
19.35Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
19.35Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
19.35Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
19.35Single6DRXLisuride6DRX-5-HT2B-Lisuride
19.35Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
19.35Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
19.35Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
19.35Single6H7MSalbutamol6H7M-β1-Salbutamol
19.35Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
19.35Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
19.35Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
19.35Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
19.35Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
19.35Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
19.35Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
19.35Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
19.35Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
19.35Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
19.35Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
19.35Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
19.35Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
19.35Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
19.35Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
19.35Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
19.35Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
19.35Single8K5DGSK2560738K5D-HCA2-GSK256073
19.35Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
19.35Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
19.35Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
19.35Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
19.35Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
19.35Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
19.35Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
19.35Single9AS1DMT9AS1-5-HT2A-DMT
19.35Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
19.35Single9IZCMK19039IZC-HCA2-MK1903-Gi1/β1/γ2
19.35Single9JEAAtropine9JEA-M1-Atropine
19.35Single9JGKBalovaptan9JGK-5-HT2B-Balovaptan
19.35Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
19.35Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
19.35Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
19.35Consensusblt_onOrthosteric Ligandblt1_on
19.35Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
19.35Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
19.35Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
19.35Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
19.35Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
19.35Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
19.35Consensushca_on_gpOrthosteric Ligandhca2_on_gp
19.35Consensusleukotriene_onOrthosteric Ligandblt_on
19.35Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
19.23Single7V68LY21196207V68-M4-Iperoxo-LY2119620-Gi1/β1/γ2
19.05Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
19.05Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
19.05Single9BYOExendin-39BYO-GLP-1-Exendin-3-Gs/β1/γ2
18.92Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
18.75Single2Y03Isoprenaline2Y03-β1-Isoprenaline
18.75Single4JKVTaladegib4JKV-SMO-Taladegib
18.75Single4NTJAZD12834NTJ-P2Y12-AZD1283
18.75Single6LUQHaloperidol6LUQ-D2-Haloperidol
18.75Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
18.75Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
18.75Single6TP6Filorexant6TP6-OX1-Filorexant
18.75Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
18.75Single7C4SS1P7C4S-S1P3-S1P
18.75Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
18.75Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
18.75Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
18.75Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
18.75Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
18.75Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
18.75Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.75Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
18.75Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
18.75Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
18.75Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
18.75Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
18.75Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
18.75Single8WGBVU01550418WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
18.75Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
18.75Single8ZMFA1L108ZMF-5-HT2C-A1L10
18.75Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
18.75Single9ARYSerotonin9ARY-5-HT2A-Serotonin-chim(NtGi1-Gs-CtGq)/β1/γ2
18.75Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
18.75Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
18.75Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
18.75Single9DYDAsenapine9DYD-5-HT1A-Asenapine-Go/β1/γ2
18.75Single9DYFAsenapine9DYF-5-HT1A-Asenapine-Gi1/β1/γ2
18.75Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
18.75Single9GE2ML1849GE2-GPR55-ML184-chim(NtGi1-G13)/β1/γ2
18.75Single9HAPTolvaptan9HAP-V2-Tolvaptan
18.75Single9KPFSA09KPF-TAS2R16-SA0-Gi1/β1/γ2
18.75Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
18.75Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
18.75Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
18.75Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.75Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.60Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
18.52Single3OE8IT1t3OE8-CXCR4-IT1t
18.52Single6OY9All-trans-Retinal6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
18.52Single6TQ9SB-4081246TQ9-OX1-SB-408124
18.52Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
18.52Single8A2OTheophylline8A2O-A2A-Theophylline-Na
18.52Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
18.52Single9CHUNoradrenaline9CHU-β2-Noradrenaline
18.52Consensusgs_histamineOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
18.52Consensush2_onOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
18.52Consensusp2y_offOrthosteric Ligandp2y1_off
18.42Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
18.18Single5V54Methiothepin5V54-5-HT1B-Methiothepin
18.18Single5V57TC1145V57-SMO-TC114
18.18Single5XR8AM8415XR8-CB1-AM841
18.18Single6E59L-7607356E59-NK1-L-760735
18.18Single6J20Aprepitant6J20-NK1-Aprepitant
18.18Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
18.18Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
18.18Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
18.18Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
18.18Single7T9NDPPC7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
18.18Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
18.18Single8EA0Iperoxo8EA0-M3-Iperoxo
18.18Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
18.18Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
18.18Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
18.18Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
18.18Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
18.18Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
18.18Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
18.18Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
18.18Single9EGOYVF9EGO-CB1-YVF-Gi1/β1/γ2
18.18Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
18.18Consensus5ht1_offOrthosteric Ligand5ht1b_off
18.18Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
18.18Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
18.18Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
18.18Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
18.18Consensusglp1_onOrthosteric Ligand7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
18.18Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
18.18Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
18.00Consensuspth_on_gpOrthosteric Ligandpth1_on_gp pth2_on_gp
17.95Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
17.95Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
17.95Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
17.95Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
17.95Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
17.95Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
17.95Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ2
17.86Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
17.86Single6ME5Agomelatine6ME5-MT1-Agomelatine
17.86Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
17.86Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
17.86Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
17.86Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
17.86Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
17.86Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
17.86Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
17.86Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
17.86Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
17.86Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
17.86Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
17.86Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
17.86Single9JHJC18:0 Ceramide9JHJ-FPR2-ALX-C18:0 Ceramide-Gi1/β1/γ2
17.86Consensus5ht2_onOrthosteric Ligand5ht2b_on
17.86Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.86Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
17.86Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
17.78Consensusglp1_on_gpOrthosteric Ligand7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
17.65Single4N4WSANT-14N4W-SMO-SANT-1
17.65Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
17.65Single4PY02MeSATP4PY0-P2Y12-2MeSATP
17.65Single5TZYMK8666; AP85TZY-FFA1-MK8666; AP8
17.65Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
17.65Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
17.65Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
17.65Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
17.65Single8JD3JNJ-404118138JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
17.65Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
17.65Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
17.65Single8Y6WTUG-13758Y6W-FFA2-TUG-1375-4-CMTB-Gi1/β1/γ2
17.65Single9DGIZ85267113509DGI-CB1-Z8526711350
17.65Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
17.65Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
17.50Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
17.50Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
17.50Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
17.50Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
17.50Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
17.50Consensusvpac_onOrthosteric Ligandvpac1_on vpac2_on
17.39Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
17.39Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
17.39Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
17.39Consensusglucagon_onOrthosteric Ligandglp_on gluc_on secretin_on gip_on
17.24Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
17.24Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
17.24Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
17.24Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
17.24Single6HLLCP999946HLL-NK1-CP99994
17.24Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
17.24Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
17.24Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
17.24Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
17.24Single6TP4ACT-4622066TP4-OX1-ACT-462206
17.24Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
17.24Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
17.24Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
17.24Single7SRQLSD7SRQ-5-HT2B-LSD
17.24Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
17.24Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
17.24Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.24Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
17.24Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
17.24Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
17.24Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
17.24Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
17.24Single9AS2DMT9AS2-5-HT2A-DMT-chim(NtGi1-Gs-CtGq)/β1/γ2
17.24Single9E7RGB889E7R-PAR2-GB88-chim(NtGi1L-Gs-CtGq)/β1/γ2
17.24Consensusgq_nucleotideOrthosteric Ligandgq_p2y
17.24Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
17.14Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
17.14Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
17.14Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
17.14Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
17.14Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
17.14Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
17.14Single8XVJMacitentan8XVJ-ETA-Macitentan
17.14Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
17.07Single6FJ3PTH6FJ3-PTH1-PTH
17.07Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
17.07Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
17.07Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
17.07Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
17.07Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
17.07Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
17.07Consensuspac1_onOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
17.07Consensuspac1_on_gpOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
17.07Consensusvpac_on_gpOrthosteric Ligandvpac1_on_gp vpac2_on_gp
17.02Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
17.02Consensusglucagon_on_gpOrthosteric Ligandglp_on_gp gluc_on_gp secretin_on_gp gip_on_gp
16.67Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
16.67Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
16.67Single4S0VSuvorexant4S0V-OX2-Suvorexant
16.67Single5ZKQABT-4915ZKQ-PAF-ABT-491
16.67Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
16.67Single6ME2Ramelteon6ME2-MT1-Ramelteon
16.67Single6ME9Ramelteon6ME9-MT2-Ramelteon
16.67Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
16.67Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
16.67Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
16.67Single6TODEMPA6TOD-OX1-EMPA-Na
16.67Single6TPJSuvorexant6TPJ-OX2-Suvorexant
16.67Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
16.67Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
16.67Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
16.67Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
16.67Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
16.67Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
16.67Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
16.67Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
16.67Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
16.67Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
16.67Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
16.67Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
16.67Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
16.67Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
16.67Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
16.67Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
16.67Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
16.67Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
16.67Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
16.67Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
16.67Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
16.67Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
16.67Single8Y0HVUF114188Y0H-CXCR3-VUF11418
16.67Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go/β1/γ2
16.67Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ2
16.67Single8YYWAlpha-ketoglutarate8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
16.67Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
16.67Single9BUCCagrilintide9BUC-CT-Cagrilintide-Gs/β1/γ2
16.67Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
16.67Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
16.67Single9EBHAdenosine9EBH-A3A-Adenosine-Gi1/β1/γ2
16.67Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single9JF4PD1683689JF4-BB1-PD168368
16.67Single9K6LSA09K6L-TAS2R16-SA0-Gi2/β1/γ2
16.67Single9KPESA09KPE-TAS2R16-SA0-Gi1/β1/γ2
16.67Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
16.67Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
16.67Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
16.67Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
16.67Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
16.67Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
16.67Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
16.67Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
16.67Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
16.67Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
16.67Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
16.67Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
16.67Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
16.33Consensuspth2_on_gpOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
16.28Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
16.28Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
16.28Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
16.28Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
16.28Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
16.28Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
16.28Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
16.28Single9BQ3Cagrilintide9BQ3-CT (AMY2)-Cagrilintide-Gs/β1/γ2; RAMP2
16.28Consensuspth1_onOrthosteric Ligand6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
16.22Single7QA8Peptide7QA8-STE2-Peptide
16.22Single7QA8Peptide7QA8-STE2-Peptide
16.22Single8IEBA1LYA8IEB-GPR156-A1LYA
16.22Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
16.13Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
16.13Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
16.13Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
16.13Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
16.13Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
16.13Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
16.13Single6TP3Nemorexant6TP3-OX1-Nemorexant
16.13Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
16.13Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
16.13Single6ZINSR486926ZIN-NTS1-SR48692
16.13Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
16.13Single7T94Acetylcholine7T94-M2-Acetylcholine-LY2119620-chim(NtGi1-Go)/β1/γ2
16.13Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
16.13Single7VODCariprazine7VOD-5-HT2A-Cariprazine
16.13Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
16.13Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
16.13Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
16.13Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
16.13Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
16.13Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
16.13Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
16.13Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
16.13Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
16.13Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
16.13Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
16.13Single8K5CAcipimox8K5C-HCA2-Acipimox
16.13Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
16.13Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
16.13Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
16.13Single9AS3LSD9AS3-5-HT2A-LSD
16.13Single9AS4LSD9AS4-5-HT2A-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
16.13Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
16.13Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
16.13Single9BA0A1AKN9BA0-CB1-A1AKN
16.13Single9LRDHistamine9LRD-H1-Histamine-Gi1/β1/γ2
16.13Consensushca_onOrthosteric Ligandhca2_on
15.91Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
15.91Consensuscrf1_onOrthosteric Ligand6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF1-Corticoliberin-Gs/β1/γ2
15.79Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
15.79Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
15.79Single8IEBA1LYA8IEB-GPR156-A1LYA
15.62Single5DSGTiotropium5DSG-M4-Tiotropium
15.62Single5T04Neurotensin5T04-NTS1-Neurotensin
15.62Single5TGZAM65385TGZ-CB1-AM6538
15.62Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
15.62Single6GPSMK08126GPS-CCR2-MK0812
15.62Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.62Single7F83PF-051904577F83-Ghrelin-PF-05190457
15.62Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
15.62Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
15.62Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
15.62Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
15.62Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
15.62Single8YN8Proxyfan8YN8-H3-Proxyfan-Go/β1/γ2
15.62Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
15.62Single9IMATalquetamab9IMA-GPRC5D-Talquetamab
15.62Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
15.62Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
15.62Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
15.62Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
15.62Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
15.62Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
15.62Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
15.56Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
15.56Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
15.56Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
15.56Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
15.38Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
15.38Single9B5YLong-Acting PTH9B5Y-PTH1-Long-Acting PTH-chim(NtGi1-Gq)/β1/γ2
15.38Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
15.38Consensusclass-b1_class-b2_cons_onOrthosteric Ligandclass-b1_on class-b2_on
15.38Consensusclass-b1_class-b2_cons_on_gpOrthosteric Ligandclass-b1_on_gp class-b2_on_gp
15.22Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
15.22Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
15.22Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
15.22Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
15.22Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.22Consensuscrf1_on_gpOrthosteric Ligand6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF1-Corticoliberin-Gs/β1/γ2
15.22Consensuspth1_on_gpOrthosteric Ligand6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
15.15Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
15.15Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
15.15Single6GPXMK08126GPX-CCR2-MK0812
15.15Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
15.15Single6Z4SSR486926Z4S-NTS1-SR48692
15.15Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
15.15Single7SINNPS-21437SIN-CaS-NPS-2143
15.15Single7SINNPS-21437SIN-CaS-NPS-2143
15.15Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
15.15Single8XYKVUF106618XYK-CXCR3-VUF10661-Go/β1/γ2
15.15Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
15.15Single9ARZ2-bromo-LSD9ARZ-5-HT2A-2-bromo-LSD
15.15Single9B9ZA1AKO9B9Z-CB1-A1AKO
15.15Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
15.15Consensusblt_offOrthosteric Ligandblt1_off
15.15Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
15.15Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
15.15Consensusep_offOrthosteric Ligandep4_off
15.15Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
15.15Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
15.15Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
15.00Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
15.00Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
15.00Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
15.00Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
15.00Single9EBOGLP-1 (ACPC18)9EBO-GLP-1-GLP-1 (ACPC18)-Gs/β1/γ2
14.89Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
14.89Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
14.89Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
14.81Single3PXOAll-trans-Retinal3PXO-Rhodopsin-All-trans-Retinal
14.81Single5DYSAll-trans-Retinal5DYS-Rhodopsin-All-trans-Retinal
14.81Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
14.81Single7WC4Serotonin7WC4-5-HT2A-Serotonin
14.81Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
14.81Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
14.81Single8PWNTheophylline8PWN-A2A-Theophylline
14.71Single5TZRMK86665TZR-FFA1-MK8666
14.71Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
14.71Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
14.71Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
14.71Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
14.71Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
14.71Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
14.71Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
14.71Single9AS9RS130-1809AS9-5-HT2A-RS130-180
14.71Single9ASARS130-1809ASA-5-HT2A-RS130-180-chim(NtGi1-Gs-CtGq)/β1/γ2
14.71Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
14.71Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
14.63Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
14.29Single3RFMCaffeine3RFM-A2A-Caffeine
14.29Single5X33BIIL2605X33-BLT1-BIIL260
14.29Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
14.29Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
14.29Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
14.29Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
14.29Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
14.29Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
14.29Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
14.29Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single8IWM2-Phenylethylamine8IWM-TA9-2-Phenylethylamine
14.29Single8WC5Tetramethylammonium Ion8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
14.29Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
14.29Single8XYIVUF106618XYI-CXCR3-VUF10661
14.29Single9BJKNAM9BJK-μ-Naloxone-NAM
14.29Single9BLBCagrilintide backbone (non-acylated)9BLB-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
14.29Single9BP3Cagrilintide9BP3-CT (AMY1)-Cagrilintide-Gs/β1/γ2; RAMP1
14.29Single9CM3TUG-13759CM3-FFA2-TUG-1375-Compound 187-chim(NtGi1L-Gs-CtGq)/β1/γ2
14.29Single9GGGI-BOP9GGG-TXA2-I-BOP-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
14.29Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
14.29Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
14.29Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
14.29Consensussensory_onOrthosteric Ligandopsins_on
14.29Consensusvpac1_on_gpOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
13.95Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
13.95Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
13.95Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
13.95Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
13.95Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
13.89Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
13.89Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
13.89Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
13.89Single9C0KExendin-49C0K-GLP-1-Exendin-4-Gs/β1/γ2
13.89Single9GG5U466199GG5-TXA2-U46619-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.89Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
13.89Consensusfp-alpha_onOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
13.89Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
13.79Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
13.79Single3PQRAll-trans-Retinal3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
13.79Single3UZAGTPL92363UZA-A2A-GTPL9236
13.79Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
13.79Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
13.79Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
13.79Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
13.79Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
13.79Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
13.79Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
13.79Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.79Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.79Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
13.79Single8IW72-Phenylethylamine8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
13.79Single8JPSCCL78JPS-ACKR1-CCL7
13.79Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
13.79Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
13.79Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
13.79Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
13.79Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
13.79Single9LRCHistamine9LRC-H4-Histamine
13.79Single9LREHistamine9LRE-H4-Histamine-Gi1/β1/γ2
13.79Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
13.79Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
13.79Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
13.79Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
13.79Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
13.73Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
13.64Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
13.64Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
13.64Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
13.51Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
13.51Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
13.51Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
13.51Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
13.51Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
13.51Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
13.51Single9CM7TUG-13759CM7-FFA2-TUG-1375-AZ-1729-Gi1/β1/γ2
13.51Single9JH6C20:0 Ceramide9JH6-CysLT2-C20:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
13.51Single9NS9TUG-13759NS9-FFA2-TUG-1375-Compound 187-Gi1/β1/γ2
13.46Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
13.33Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
13.33Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
13.33Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
13.33Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
13.33Single7RBTTirzepatide7RBT-GIP-Tirzepatide-LSN3556672-chim(NtGi1-Gs)/β1/γ2
13.33Single7UL2SR486927UL2-NTS1-SR48692-Na
13.33Single7V68Iperoxo7V68-M4-Iperoxo-LY2119620-Gi1/β1/γ2
13.33Single7XP6Strychnine7XP6-TAS2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
13.33Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
13.33Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
13.33Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
13.33Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
13.33Single8K5BNiacin8K5B-HCA2-Niacin
13.33Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab
13.33Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
13.33Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
13.33Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.33Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
13.33Single8YN2Histamine8YN2-H1-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.33Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
13.33Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
13.33Single8YN7Immethridine8YN7-H3-Immethridine-Go/β1/γ2
13.33Single9AS7Psilocin9AS7-5-HT2A-Psilocin
13.33Single9B9Y7DY9B9Y-CB1-7DY
13.33Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
13.33Single9EPRRetinal9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
13.33Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
13.33Single9IZDCHBA9IZD-HCA1-CHBA-Gi1/β1/γ2
13.33Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
13.33Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
13.33Consensusneurotensin_offOrthosteric Ligandnts1_off
13.33Consensusnts1_offOrthosteric Ligand7UL2-NTS1-SR48692-Na
13.16Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
13.16Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.16Single8IEIA1LYA8IEI-GPR156-A1LYA
13.16Single8IEIA1LYA8IEI-GPR156-A1LYA
13.16Single8IEPA1LYA8IEP-GPR156-A1LYA
13.16Single8IEPA1LYA8IEP-GPR156-A1LYA
13.16Single8KIGSHU91198KIG-MC3-SHU9119-Ca
13.16Single8YWFRetatrutide8YWF-GLP-1-Retatrutide-chim(NtGi1-Gs)/β1/γ2
12.90Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
12.90Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
12.90Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
12.90Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
12.90Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
12.90Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
12.90Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
12.90Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
12.90Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
12.90Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
12.90Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
12.90Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
12.90Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
12.90Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
12.90Single8IWESpermidine8IWE-TA9-Spermidine
12.90Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
12.90Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
12.90Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
12.90Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
12.90Consensusangiotensin_offOrthosteric Ligandat1_off
12.90Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
12.90Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
12.90Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
12.90Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
12.90Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
12.77Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
12.50Single6TPKRetosiban6TPK-OT-Retosiban
12.50Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
12.50Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
12.50Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
12.50Single8K2WAMG4878K2W-CXCR3-AMG487
12.50Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single9IXXLTD49IXX-CysLT2-LTD4-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
12.50Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
12.50Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
12.50Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
12.50Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
12.50Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
12.50Consensusvasop-oxy_offOrthosteric Ligandot_off
12.20Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
12.20Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
12.20Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
12.12Single4YAYZD-71554YAY-AT1-ZD-7155
12.12Single6IIVDaltroban6IIV-TXA2-Daltroban
12.12Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/β1/γ2
12.12Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
12.12Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
12.12Single7YXAONO-54306087YXA-S1P5-ONO-5430608
12.12Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
12.12Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
12.12Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
12.12Single9IYAONO-97105319IYA-GPR55-ONO-9710531
12.12Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
12.12Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
11.90Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
11.90Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
11.90Consensuscalcitonin_onOrthosteric Ligandctlike_on
11.90Consensusvpac1_onOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
11.76Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
11.76Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
11.76Single5CGCHTL142425CGC-mGlu5-HTL14242
11.76Single5T1ABMS-6815T1A-CCR2-BMS-681-PubChem 12093170
11.76Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
11.76Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
11.76Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
11.76Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
11.76Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
11.76Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
11.76Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
11.63Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
11.63Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
11.63Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
11.63Single9BUBCagrilintide9BUB-CT-Cagrilintide-Gs/β1/γ2
11.63Consensuscalcitonin_on_gpOrthosteric Ligandctlike_on_gp
11.63Consensussecretin_onOrthosteric Ligand7D3S-Secretin-Secretin-Gs/β1/γ2
11.43Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
11.43Single8JD5JNJ-40411813; ADX881788JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
11.43Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
11.43Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
11.43Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
11.43Single8YNTSNAP-948478YNT-MCH1-SNAP-94847
11.43Single8ZW0PGD28ZW0-DP1-PGD2-Gs/β1/γ2
11.43Single9CLWTUG-13759CLW-FFA2-TUG-1375-4-CMTB-chim(NtGi1L-Gs-CtGq)/β1/γ2
11.43Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
11.36Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
11.36Consensussecretin_on_gpOrthosteric Ligand7D3S-Secretin-Secretin-Gs/β1/γ2
11.11Single4A4MAll-trans-Retinal4A4M-Rhodopsin-All-trans-Retinal-Gt(CT)
11.11Single5EN0All-trans-Retinal5EN0-Rhodopsin-All-trans-Retinal-Gt(CT)
11.11Single5MZPCaffeine5MZP-A2A-Caffeine-Na
11.11Single6IIURamatroban6IIU-TXA2-Ramatroban
11.11Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
11.11Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.11Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
11.11Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
11.11Single8XJNCloprosetnol8XJN-TXA2-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
11.11Consensusvpac2_on_gpOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
10.87Consensusgip_onOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
10.87Consensusgip_on_gpOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
10.81Single5CGDHTL142425CGD-mGlu5-HTL14242
10.81Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
10.81Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
10.81Single8XJOU466198XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
10.81Single9JH5C16:0 Ceramide9JH5-CysLT2-C16:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
10.81Single9M1HProstaglandin E29M1H-EP1-Prostaglandin E2-chim(NtGi1-Gs-CtGq)/β1/γ2
10.81Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
10.81Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
10.81Consensustp_onOrthosteric Ligand8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
10.81Consensustp_on_gpOrthosteric Ligand8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
10.71Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
10.71Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
10.64Single9AUCCalcitonin gene-related peptide-19AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
10.53Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
10.53Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
10.34Single2HPYAll-trans-Retinal2HPY-Rhodopsin-All-trans-Retinal
10.34Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
10.34Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
10.34Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
10.34Single9EE9Adenosine9EE9-A2A-Adenosine-Gs/β1/γ2
10.26Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
10.26Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
10.26Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
10.20Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
10.00Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
10.00Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
10.00Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
10.00Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
10.00Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
10.00Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
10.00Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
10.00Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
10.00Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
10.00Consensusgi_sensoryOrthosteric Ligandgi_opsins
10.00Consensusgluc_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
10.00Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
10.00Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
9.80Consensusgluc_on_gpOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
9.68Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
9.68Single6LI0C176LI0-GPR52-C17
9.68Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
9.68Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
9.68Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
9.68Single8ZYUNeurotensin peptide 8-138ZYU-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
9.68Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg4_on
9.68Consensusadgrg_on_gpOrthosteric Ligandadgrg2_on_gp adgrg4_on_gp
9.52Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
9.52Single9BLCCagrilintide backbone (non-acylated)9BLC-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
9.52Single9BUDCagrilintide9BUD-CT-Cagrilintide-Gs/β1/γ2
9.52Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
9.38Single5U09Taranabant5U09-CB1-Taranabant
9.38Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
9.38Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.38Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
9.38Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
9.38Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
9.38Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
9.38Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
9.30Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
9.09Single7VV6C48/807VV6-MRGPRX2-C48/80
9.09Single8YRGFospropofol8YRG-MRGPRX4-Fospropofol-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Consensuscrf2_on_gpOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
9.09Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
8.89Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
8.82Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
8.70Single9BTWCagrilintide9BTW-CT (AMY3)-Cagrilintide-Gs/β1/γ2; RAMP3
8.70Consensusctlike_on_gpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
8.57Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
8.57Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
8.57Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
8.57Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
8.57Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
8.57Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
8.57Single9HC04YI9HC0-mGlu5-4YI
8.57Consensusadgrg2_onOrthosteric Ligand7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
8.57Consensusadgrg2_on_gpOrthosteric Ligand7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
8.33Single7P2L4YI7P2L-mGlu5-4YI
8.33Single8GDBPGE28GDB-EP4-PGE2-Gs/β1/γ2
8.33Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
8.11Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
8.11Single9AU0BW245C9AU0-DP1-BW245C-Gs/β1/γ2
7.89Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
7.69Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
7.50Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
7.50Single9BUECagrilintide9BUE-CT-Cagrilintide-Gs/β1/γ2
7.41Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
7.41Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
7.14Single8GEJConstrained Epinephrine8GEJ-β2-Constrained Epinephrine-Gs/β1/γ2
6.90Single7XKDBeta-Hydroxyandrosterone7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
6.67Single6XBM5LWE6XBM-SMO-5LWE-Gi1/β1/γ2
6.67Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
6.67Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Gi1/β1/γ2
6.67Single8Y02Retinal8Y02-OPN1SW-Retinal-Gi1/β1/γ2
6.52Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
6.52Consensusglp2_on_gpOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
6.45Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
6.45Single8J6QCompound 9n8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
6.45Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
6.25Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.25Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
6.25Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
6.25Single8HSCFab0468HSC-GPR20-Fab046-Gi1/β1/γ2
6.25Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
6.25Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/β1/γ2
6.25Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
6.06Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.06Single8T3VDocosa-4,7,10,13,16,19-Hexaenoic acid8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.88Single6FFIMMPEP6FFI-mGlu5-MMPEP
5.88Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
5.71Single6FFHFenobam6FFH-mGlu5-Fenobam
5.71Single9IVGGLP-1 (Truncated)9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
5.56Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.56Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
5.56Single8ZVZBW245C8ZVZ-DP1-BW245C-Gs/β1/γ2
5.41Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
5.41Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
3.70Single8W8SAA-148W8S-GPR101-AA-14
3.70Consensusclass-b2_onOrthosteric Ligandadgrg_on adgrf_on adgrl_on adgre_on adgrd_on
3.70Consensusclass-b2_on_gpOrthosteric Ligandadgrg_on_gp adgrf_on_gp adgrl_on_gp adgre_on_gp adgrd_on_gp
3.57Single8W8RAA-148W8R-GPR101-AA-14-chim(NtGi1-Gs)/β1/γ2
3.45Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/β1/γ2
3.33Single8HS2Fab0468HS2-GPR20-Fab046
3.33Single8X9S5alpha-DHT8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
3.23Single7Y14Beta-Alanine7Y14-MRGPRD-β-Alanine
3.12Single7Y12Beta-Alanine7Y12-MRGPRD-β-Alanine-Gi1/β1/γ2
3.03Single8YKDDehydroepiandrosterone8YKD-ADGRG2-Dehydroepiandrosterone-chim(NtGi1-Gs)/β1/γ2
2.94Single4K5YCP-3763954K5Y-CRF1-CP-376395
2.94Single4XNVBPTU4XNV-P2Y1-BPTU
2.94Single7VVOPTH7VVO-PTH1-PTH-Gs/β1/γ2
2.86Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
2.86Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ2
2.86Single8IYXYL-3658IYX-GPR34-YL-365
2.86Single8JD6VU03647708JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
2.78Single4Z9GCP-3763954Z9G-CRF1-CP-376395
2.78Single8GTIBMK-C2058GTI-CRF1-BMK-C205
2.70Single8GTGBMK-I1528GTG-CRF1-BMK-I152
2.63Single8JD5JNJ-40411813; ADX881788JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
2.63Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Gi1/β1/γ1
2.56Single8GTMBMK-C2038GTM-CRF1-BMK-C203

Consensus Members
Id Members
8IY5 8IY5-ETB-Endothelin-1-Gi1/β1/γ2
8HBD 8HBD-ETB-IRL1620-Gi1/β1/γ2
Net Summary
Imin 2.665
Number of Linked Nodes 908
Number of Links 1147
Number of Hubs 196
Number of Links mediated by Hubs 723
Number of Communities 30
Number of Nodes involved in Communities 297
Number of Links involved in Communities 451
Path Summary
Number Of Nodes in MetaPath 128
Number Of Links MetaPath 127
Number of Shortest Paths 1861959
Length Of Smallest Path 3
Average Path Length 39.5373
Length of Longest Path 82
Minimum Path Strength 0.625
Average Path Strength 5.58214
Maximum Path Strength 25.67
Minimum Path Correlation 0.7
Average Path Correlation 0.980616
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.51515
Average % Of Corr. Nodes 36.455
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 54.5401
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following differences:
Id1st Network2nd Network
etb_off_on_gpetb_on_gpetb_off
This network is also present in following consensuses:
IdComponents
endothelin_on_gpetb_on_gp
eta_on_gp



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Download etb_on_gp.zip



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