Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
1g.h1x1 1.76771402
2g.ctx3 2.88201609
3g.ctx6 1.55016406
4NT 5.43067514
51x35 7.69214405
61x39 6.44239636
71x50 5.7012409
81x55 2.20655404
91x60 2.41513406
102x40 3.06976508
112x42 4.72272508
122x44 3.204425115
132x50 5.01243509
142x53 4.77212408
152x57 3.67465536
163x42 5.37149458
173x49 5.07485549
183x50 3.57318509
193x51 6.29355407
20I2x51 2.11335406
21I2x53 4.89095447
224x38 2.21271508
234x50 5.37551459
244x63 2.67262515
25E2 13.39521613
265x39 6.24019516
275x461 4.44599408
285x51 2.83159406
295x58 4.6976669
305x68 1.73532407
316x26 0.783782403
326x48 6.23081608
336x59 3.28042404
34E3 3.85703613
357x31 4.68649413
367x35 6.71789403
377x49 4.60675409
387x53 3.22588409
398x50 3.65091509
40Lig 7.589181110
41G.S2.02 0.985469406
42G.S2.06 2.47408508
43G.S3.03 2.996507
44G.S3.04 4.36729407
45G.S4.04 2.88031409
46G.s4h3.04 3.35693408
47G.H3.01 2.43943409
48G.H3.09 3.1925409
49G.H3.17 3.71234405
50G.H3.18 2.74937409
51G.S5.05 1.88818409
52G.HG.14 1.26552405
53G.hgh4.05 3.533506
54G.H4.03 1.77865404
55G.H4.08 1.22401403
56G.H4.10 3.78521406
57G.H4.15 2.69068408
58G.S6.02 2.94467508
59G.S6.05 1.95906605
60G.s6h5.02 1.23937407
61G.H5.13 2.08975507
62b.1x1 1.35896404
63b.1x7 1.40854408
64b.1x11 1.49469408
65b.lhb1x3 1.0762402
66b.b1x4 2.10688407
67b.l1x3 5.0887409
68b.b2x5 3.11038607
69b.b3x3 1.66927408
70b.l3x2 2.94958409
71b.b4x6 5.80792409
72b.b5x2 2.63708407
73b.b5x3 3.17825509
74b.b5x7 2.53526407
75b.l5x5 3.5124609
76b.b6x5 1.92108506
77b.b7x1 2.83255404
78b.l9x6 2.57007608
79b.b10x5 2.43464409
80b.l10x1 1.90292403
81b.l11x2 3.84698489
82b.b12x6 4.53354608
83b.b13x7 3.717597
84b.l13x3 4.02046509
85b.l15x2 2.9638409
86b.b16x6 4.21613598
87b.l17x3 4.75558509
88b.l17x6 2.84388509
89b.l18x1 3.41455606
90b.b19x2 3.879694106
91b.l19x2 3.46063409
92b.b20x6 3.939484106
93b.b21x2 1.835406
94b.b21x5 1.92375404
95b.b21x7 2.83719605
96b.b22x5 2.99875407
97b.l22x5 3.85219409
98b.b23x6 3.35753607
99b.l23x1 3.71214406
100b.l24x3 2.01339405
101b.l27x1 5.51767509
102b.l27x2 4.09854429
103b.b28x2 2.92188404
104b.b28x6 4.19775529
105G.HN.29 0.151094400
106E1 2.187500
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
17x31 7x35 17.47687.88295YesYes033
27x31 Lig 17.48294.09633YesYes130
36x51 Lig 56.77966.00505NoYes060
46x51 7x41 58.9083.72676NoNo067
56x48 7x41 59.31374.33194YesNo087
63x40 6x48 95.86948.91354NoYes088
73x40 5x50 96.04563.04938NoNo088
83x44 5x50 96.39452.79619NoNo078
93x44 5x54 96.73863.26909NoNo078
103x47 5x54 95.58334.30329NoNo698
113x47 5x57 97.31872.44875NoNo096
123x51 5x57 97.47925.84694YesNo076
133x51 3x55 99.58359.7045YesNo077
143x55 3x56 99.72354.89327NoNo076
153x56 I2x52 99.86244.89604NoNo065
16I2x51 I2x52 1001.98237YesNo065
17G.S3.01 I2x51 98.4742.83208NoYes046
18G.S3.01 G.S3.03 98.31292.90979NoYes047
19G.S2.06 G.S3.03 97.5075.60479YesYes087
20G.S2.06 G.S3.05 96.541.73625YesNo087
21G.S1.06 G.S3.05 96.37882.88625NoNo097
22G.S1.06 G.S4.03 94.76722.065NoNo098
23G.S4.03 G.S5.05 94.6061.79NoYes089
24G.S5.05 G.s6h5.01 93.47782.67521YesNo099
25G.S5.07 G.s6h5.01 92.51082.16292NoNo099
26G.S5.07 G.s5hg.01 92.02731.48646NoNo099
27G.s4h3.02 G.s5hg.01 90.73791.97625NoNo099
28G.HG.07 G.s4h3.02 90.41561.59375NoNo099
29G.HG.07 G.s4h3.04 90.25444.97063NoYes098
30G.HG.04 G.s4h3.04 85.74172.42667NoYes088
31G.HG.04 G.s4h3.01 85.25823.76396NoNo086
32G.S5.06 G.s4h3.01 85.0973.44542NoNo096
33G.S5.06 G.S6.05 84.93592.81646NoYes095
34G.H4.12 G.S6.05 80.74551.95729NoYes055
35G.H4.12 G.S6.03 80.42316.40833NoNo055
36G.S5.04 G.S6.03 80.2623.30125NoNo095
37G.H4.15 G.S5.04 80.10082.48708YesNo089
38G.H3.09 G.H4.15 78.00562.47813YesYes098
39G.H3.09 G.S4.04 75.91045.58146YesYes099
40G.S1.07 G.S4.04 74.94342.33563NoYes099
41G.S1.05 G.S1.07 74.62113.54625NoNo099
42G.S1.05 G.h2s4.01 74.45995.53125NoNo099
43G.h2s4.01 b.l5x5 74.13765.61708NoYes099
44b.l3x1 b.l5x5 49.47882.35021NoYes099
45b.b2x1 b.l3x1 49.31766.50604NoNo089
46b.b2x1 b.l27x1 48.99534.11938NoYes089
47b.b26x1 b.l27x1 33.68422.44479NoYes099
48b.b26x1 b.b26x2 33.52311.68417NoNo097
49b.b26x2 b.b2x3 33.20072.6325NoNo076
50b.b2x3 b.b2x5 33.03962.20646NoYes067
51b.b2x5 b.b3x2 18.85674.86333YesNo075
52b.b3x2 b.b4x6 18.69562.44458NoYes059
53b.b4x4 b.b4x6 16.60047.07146NoYes089
54b.b4x4 b.l1x3 16.43925.49625NoYes089
55b.b3x6 b.l1x3 15.95575.81125NoYes099
56b.b3x6 b.l3x2 15.79454.50854NoYes099
57b.b4x2 b.l3x2 15.14993.17NoYes089
58b.b4x2 b.b5x8 14.50521.81208NoNo085
59b.b5x7 b.b5x8 14.3441.55333YesNo075
60b.b4x3 b.b5x7 12.08762.61667NoYes077
61b.b3x3 b.b4x3 11.28181.58312YesNo087
627x35 7x38 17.32773.9268YesNo035
637x38 Lig 17.78897.18147NoYes150
641x35 7x35 31.62299.05505YesYes053
651x35 1x39 21.983513.0236YesYes056
661x39 2x57 11.04585.82737YesYes366
672x50 7x49 15.17345.67881YesYes099
687x45 7x49 56.07946.31163NoYes099
696x48 7x45 56.95837.45234YesNo089
701x57 2x40 12.90742.78008NoYes088
711x57 2x43 17.67242.77625NoNo088
722x43 7x53 18.22774.29774NoYes089
737x49 7x53 38.18913.03332YesYes099
742x39 3x49 13.82977.14681NoYes089
752x39 3x50 13.97585.28928NoYes089
763x50 7x53 21.30383.49396YesYes099
77E1x50 E2x50 11.93926.75736NoNo039
78E2 Lig 10.87810.6871YesYes130
79b.l5x5 b.l7x2 22.40242.58583YesNo099
80G.H2.07 b.l7x2 22.24131.75583NoNo099
81G.H2.07 b.l9x6 21.91892.71312NoYes098
82b.l13x6 b.l9x6 14.02173.71167NoYes098
83b.l13x6 b.l15x1 13.86052.52896NoNo097
84b.l15x1 b.l17x6 13.69933.76083NoYes079
85b.l17x5 b.l17x6 12.57121.44229NoYes069
86b.l17x5 b.l19x2 12.412.02479NoYes069
87b.b19x6 b.l19x2 11.76533.64958NoYes099
88b.b19x6 b.l17x3 11.60416.16062NoYes099
89b.b19x4 b.l17x3 10.4764.47729NoYes089
90b.b19x4 b.b20x6 10.31483.78229NoYes086
91b.l25x6 b.l27x1 13.05477.43458NoYes089
92b.l23x1 b.l25x6 12.89359.52792YesNo068
93b.b2x5 b.l26x1 13.53825.58479YesNo077
94b.l26x1 b.l26x3 13.21583.40354NoNo777
95b.l26x3 b.l26x5 13.05473.03167NoNo075
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
3x223x264.730061NoNo3522
3x22E215.93541NoYes3321
3x25E24.714461NoYes9321
3x26E26.891231NoYes5321
3x29E2x526.798780NoNo4421
3x33Lig4.778590NoYes4010
4x63E24.10251YesYes5321
5x39E26.025191YesYes6321
E2E260.28231YesYes3311
5x36E212.21551NoYes5321
E2E2x5111.82421YesNo3412
E2E2x527.542721YesNo3411
E2x52Lig19.72761NoYes4010
E2Lig10.68711YesYes3010
5x406x555.731940NoNo5521
6x517x413.726760NoNo6712
6x51Lig6.005050NoYes6010
6x55Lig5.768320NoYes5010
E3E33.492551YesYes3322
7x317x357.882951YesYes3312
7x38Lig7.181471NoYes5010
7x347x385.621331NoNo4511
7x34Lig4.84671NoYes4010
7x357x383.92680YesNo3521
7x31Lig4.096331YesYes3010
6x58Lig5.42571NoYes4010
E3NT6.903331YesYes3421
7x24NT3.579170NoYes0421
LigNT6.771671YesYes0401
7x28NT4.50750NoYes0421
7x31NT5.391671YesYes3411
E1x49E24.954170NoYes0321
4x635x364.9651YesNo5522
4x64E23.44750NoYes0321
5x336x623.948330NoNo0021
6x587x349.96751NoNo4411
6x62Lig8.19250NoYes0010
5x376x552.961990NoNo3521
3x23E22.739380NoYes1321
6x517x372.713220NoNo6512
3x21E22.559580NoYes6321
1x287x311.3750NoYes0321
5x30E20.120NoYes0321

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
90.91Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
62.50Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
58.33Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
57.14Consensusa3_onOrthosteric Liganda3a_on
55.56Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
54.55Single8A2OTheophylline8A2O-A2A-Theophylline-Na
54.55Consensusp2y_offOrthosteric Ligandp2y1_off
53.85Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
53.85Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
53.85Single8GNGIstradefylline8GNG-A2A-Istradefylline
53.85Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
53.85Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
53.85Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
53.85Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
53.85Single8YYWAlpha-ketoglutarate8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
53.85Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
53.33Consensusa3_on_gpOrthosteric Liganda3a_on_gp
53.33Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
53.33Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
53.33Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
50.00Single4XNWMRS25004XNW-P2Y1-MRS2500
50.00Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
50.00Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
50.00Single6MH8ZM-2413856MH8-A2A-ZM-241385
50.00Single7AROLUF58337ARO-A2A-LUF5833-Na
50.00Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
50.00Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
50.00Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
50.00Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
50.00Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
50.00Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
50.00Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
50.00Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
50.00Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
50.00Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
50.00Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
50.00Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
47.62Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
47.62Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
47.62Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
47.37Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
47.37Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
47.37Single9BUYLM1899BUY-β2-LM189-Gi1/β1/γ2
47.37Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
47.37Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
47.06Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
47.06Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
47.06Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
47.06Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
46.67Single3EMLZM-2413853EML-A2A-ZM-241385
46.67Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
46.67Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
46.67Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
46.67Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
46.67Single6S0LZM-2413856S0L-A2A-ZM-241385
46.67Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
46.67Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
46.67Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
46.67Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
46.15Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
45.45Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
45.45Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
45.45Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
45.45Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
45.45Single8PWNTheophylline8PWN-A2A-Theophylline
45.00Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
44.44Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
44.44Single7EZCUKA7EZC-A2A-UKA
44.44Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
44.44Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
44.44Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
44.00Single5GLHEndothelin-15GLH-ETB-Endothelin-1
43.75Single5IUAQ274563485IUA-A2A-Q27456348-Na
43.75Single5N2RPSB-365N2R-A2A-PSB-36-Na
43.75Single5N2SPSB365N2S-A1-PSB36
43.75Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
43.75Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
43.75Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
43.75Single6S0QZM-2413856S0Q-A2A-ZM-241385
43.75Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
43.75Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
43.75Single7LD3Adenosine7LD3-A1-Adenosine-MIPS521-Gi2/β1/γ2
43.75Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
43.75Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
43.75Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
43.75Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
43.75Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
43.75Single8GNEKW-63568GNE-A2A-KW-6356-Na
43.75Single8S4DCMF-0198S4D-Apelin-CMF-019
43.75Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
43.75Single9EHSLUF76029EHS-A3A-LUF7602
43.75Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
43.75Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
43.48Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
43.48Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
42.86Single3OE0CVX153OE0-CXCR4-CVX15
42.86Single3PWHZM-2413853PWH-A2A-ZM-241385
42.86Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
42.86Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
42.86Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
42.86Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
42.86Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
42.86Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
42.86Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
42.86Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
42.86Single9EBHAdenosine9EBH-A3A-Adenosine-Gi1/β1/γ2
42.86Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
42.86Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
42.86Consensusangiotensin_onOrthosteric Ligandat1_on
42.86Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
42.86Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
42.86Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
42.11Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
42.11Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
42.11Single8QJ2pN1628QJ2-MC4-pN162-Gs
42.11Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
42.11Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
41.67Single3RFMCaffeine3RFM-A2A-Caffeine
41.67Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
41.67Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
41.67Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
41.18Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
41.18Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
41.18Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
41.18Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
41.18Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
41.18Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
41.18Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
41.18Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
41.18Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
41.18Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
41.18Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
41.18Single9JMCDS-3801b9JMC-Motilin-DS-3801b-chim(Gs-CtGq)/β1/γ2
41.18Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
41.18Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
40.91Single6JODAngiotensin II6JOD-AT2-Angiotensin II
40.91Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
40.91Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
40.91Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
40.91Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
40.91Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
40.91Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
40.91Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
40.91Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
40.74Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
40.00Single3REYXAC3REY-A2A-XAC
40.00Single4IARErgotamine4IAR-5-HT1B-Ergotamine
40.00Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
40.00Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
40.00Single5IU7Q274563465IU7-A2A-Q27456346-Na
40.00Single5IUBQ274563445IUB-A2A-Q27456344-Na
40.00Single5JTBZM-2413855JTB-A2A-ZM-241385
40.00Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
40.00Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
40.00Single5UVIZM-2413855UVI-A2A-ZM-241385
40.00Single6AQFZM-2413856AQF-A2A-ZM-241385
40.00Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
40.00Single7T32ZM-2413857T32-A2A-ZM-241385
40.00Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
40.00Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
40.00Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
40.00Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
40.00Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
40.00Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
40.00Single8WDTphotoNECA8WDT-A2A-photoNECA
40.00Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
40.00Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
40.00Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
40.00Single9JH3CMF-0199JH3-Apelin-CMF-019-Gi1/β1/γ2
40.00Single9JMDAzithromycin9JMD-Motilin-Azithromycin-chim(Gs-CtGq)/β1/γ2
40.00Consensusa2_offOrthosteric Liganda2a_off
40.00Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
40.00Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
40.00Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
40.00Consensusbradykinin_onOrthosteric Ligandbk2_on
40.00Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
40.00Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
40.00Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
40.00Consensusendothelin_onOrthosteric Ligandetb_on eta_on
40.00Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
40.00Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
40.00Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
39.13Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
39.13Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
39.13Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
39.13Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
39.13Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
38.89Single4XEENeurotensin4XEE-NTS1-Neurotensin
38.89Single4XESNeurotensin4XES-NTS1-Neurotensin
38.89Single6MXTSalmeterol6MXT-β2-Salmeterol
38.89Single6OS2TRV0266OS2-AT1-TRV026
38.89Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
38.89Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
38.89Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
38.89Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
38.89Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
38.89Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
38.89Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
38.89Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
38.89Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
38.89Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
38.89Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
38.89Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
38.89Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
38.89Consensuslpa_offOrthosteric Ligandlpa1_off
38.89Consensuslpl_offOrthosteric Ligands1p_off lpa_off
38.89Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
38.46Single6IGKEndothelin-36IGK-ETB-Endothelin-3
38.46Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/β1/γ2
38.46Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
38.10Single3QAKUK-4320973QAK-A2A-UK-432097
38.10Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
38.10Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
38.10Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
38.10Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
38.10Single9IQSMuscarinic toxin 39IQS-M4-Muscarinic toxin 3
38.10Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
38.10Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
37.50Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
37.50Single4QIMANTA XV4QIM-SMO-ANTA XV
37.50Single5IU8Q274563475IU8-A2A-Q27456347-Na
37.50Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
37.50Single5UENDU1725UEN-A1-DU172
37.50Single5UIGCmpd-15UIG-A2A-Cmpd-1
37.50Single6D27CAY104716D27-DP2-CAY10471
37.50Single6PS1Timolol6PS1-β2-Timolol
37.50Single6XBM5LWE6XBM-SMO-5LWE-Gi1/β1/γ2
37.50Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
37.50Single7PYRPSB-21157PYR-A2A-PSB-2115
37.50Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
37.50Single8CU6LJ-45178CU6-A2A-LJ-4517
37.50Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
37.50Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
37.50Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
37.50Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
37.50Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
37.50Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
37.50Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
37.50Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
37.50Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
37.50Single9CHXS-Carazolol9CHX-β2-S-Carazolol
37.50Single9H37A1IR09H37-A2A-A1IR0-Na
37.50Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
37.50Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
37.04Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
36.84Single4BUONeurotensin4BUO-NTS1-Neurotensin
36.84Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
36.84Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
36.84Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
36.84Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
36.84Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
36.84Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
36.84Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
36.84Single8XVUCXCL28XVU-CXCR2-CXCL2
36.84Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
36.84Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
36.84Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
36.36Single5MZPCaffeine5MZP-A2A-Caffeine-Na
36.36Single5WF5UK-4320975WF5-A2A-UK-432097
36.36Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
36.36Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
36.36Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
36.00Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
36.00Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
36.00Single9KDFRES-701-39KDF-ETB-RES-701-3
36.00Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
36.00Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
35.71Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
35.71Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
35.71Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
35.71Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
35.29Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
35.29Single5C1MBU725C1M-μ-BU72
35.29Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
35.29Single6D26Fevipiprant6D26-DP2-Fevipiprant
35.29Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
35.29Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
35.29Single7C61Ergotamine7C61-5-HT1B-Ergotamine
35.29Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
35.29Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
35.29Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
35.29Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
35.29Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
35.29Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
35.29Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
35.29Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
35.29Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
35.29Single8QOTNanobody-E8QOT-μ-Nanobody-E
35.29Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
35.29Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
35.29Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
35.29Single8ZYTNeurotensin peptide 8-138ZYT-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
35.29Single9EE8Adenosine9EE8-A2A-Adenosine-Gs/β1/γ2
35.29Consensusadenosine_offOrthosteric Liganda1_off a2_off
35.29Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
35.29Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
35.29Consensusdp_offOrthosteric Liganddp2_off
35.29Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
35.00Single3NY9ICI118-5513NY9-β2-ICI118-551
35.00Single4UG2CGS216804UG2-A2A-CGS21680
35.00Single5WF6UK-4320975WF6-A2A-UK-432097
35.00Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
35.00Single6KNMJN241-96KNM-Apelin-JN241-9
35.00Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
35.00Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
35.00Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
35.00Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
35.00Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
35.00Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
35.00Single8XQJJN2418XQJ-Apelin-JN241
35.00Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
35.00Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
35.00Single9V2NMacimorelin9V2N-Ghrelin-Macimorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
35.00Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
35.00Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
35.00Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
35.00Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
34.78Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
34.78Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
34.78Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
34.62Single6IGLIRL16206IGL-ETB-IRL1620
34.62Single8IY6Endothelin-18IY6-ETB-Endothelin-1
33.33Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
33.33Single2YDVNECA2YDV-A2A-NECA
33.33Single3P0GBI1671073P0G-β2-BI167107
33.33Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
33.33Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
33.33Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
33.33Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
33.33Single4UHRCGS216804UHR-A2A-CGS21680
33.33Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
33.33Single5G53NECA5G53-A2A-NECA-Gs
33.33Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
33.33Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
33.33Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
33.33Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
33.33Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
33.33Single6OS1TRV0266OS1-AT1-TRV026
33.33Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
33.33Single7BR3Elagolix7BR3-GnRH1-Elagolix
33.33Single7F1TMIP-1a7F1T-CCR5-MIP-1a
33.33Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
33.33Single7F8ULintitript7F8U-CCKA-Lintitript
33.33Single7F8XNN90567F8X-CCKA-NN9056
33.33Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
33.33Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
33.33Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
33.33Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
33.33Single7PX4PSB-21137PX4-A2A-PSB-2113
33.33Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
33.33Single7T9NDPPC7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
33.33Single7TUYGSK682753A7TUY-GPR183-GSK682753A
33.33Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
33.33Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
33.33Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
33.33Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
33.33Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
33.33Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
33.33Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
33.33Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
33.33Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
33.33Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
33.33Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
33.33Single8E0GBU728E0G-μ-BU72
33.33Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
33.33Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
33.33Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
33.33Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
33.33Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
33.33Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
33.33Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
33.33Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
33.33Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
33.33Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
33.33Single8U4PAMD31008U4P-CXCR4-AMD3100-Gi1/β1/γ2
33.33Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
33.33Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
33.33Single8XWNCXCL88XWN-CXCR2-CXCL8
33.33Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
33.33Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
33.33Single8ZWFJR14a8ZWF-C3aB-JR14a
33.33Single9EEAAdenosine9EEA-A2A-Adenosine-Gs/β1/γ2
33.33Single9H2XA1IR19H2X-A2A-A1IR1-Na
33.33Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single9J0IUDP-Glucuronic acid9J0I-P2Y14-UDP-Glucuronic acid-Gi1/β1/γ2
33.33Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
33.33Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
33.33Single9UY3Anamorelin9UY3-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Consensusa2_onOrthosteric Liganda2b_on
33.33Consensusa2_on_gpOrthosteric Liganda2b_on_gp
33.33Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
33.33Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
33.33Consensusalpha2_offOrthosteric Ligandalpha2c_off
33.33Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
33.33Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
33.33Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
33.33Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
33.33Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
33.33Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
33.33Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
33.33Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
33.33Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
33.33Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
33.33Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
33.33Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
33.33Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
33.33Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
33.33Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
33.33Consensuslpa_onOrthosteric Ligandlpa1_on
33.33Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
33.33Consensuslpl_onOrthosteric Ligands1p_on lpa_on
33.33Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
33.33Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
33.33Consensusneurotensin_onOrthosteric Ligandnts1_on
33.33Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
33.33Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
33.33Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
32.14Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
32.00Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
32.00Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
31.82Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
31.82Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
31.82Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
31.82Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
31.82Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
31.82Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
31.82Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
31.82Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
31.82Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
31.82Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
31.82Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
31.82Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
31.82Single9IQRMuscarinic toxin 39IQR-α2a-Muscarinic toxin 3
31.82Single9J0FNADH9J0F-P2Y14-NADH-Gi1/β1/γ2
31.82Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
31.82Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
31.82Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
31.82Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
31.82Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
31.82Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
31.82Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
31.82Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
31.58Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
31.58Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
31.58Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
31.58Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
31.58Single4RWADIPP-NH24RWA-δ-DIPP-NH2
31.58Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
31.58Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
31.58Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
31.58Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
31.58Single6YVRNTS8-136YVR-NTS1-NTS8-13
31.58Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
31.58Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
31.58Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
31.58Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
31.58Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
31.58Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
31.58Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
31.58Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
31.58Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
31.58Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
31.58Single8JJ8Formoterol8JJ8-β2-Formoterol
31.58Single8JJLOlodaterol8JJL-β2-Olodaterol
31.58Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
31.58Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
31.58Single8JWY2-1188JWY-A2A-2-118
31.58Single8XQJJN2418XQJ-Apelin-JN241
31.58Single8XWACXCL18XWA-CXCR2-CXCL1
31.58Single8XWMCXCL68XWM-CXCR2-CXCL6
31.58Single8XWSCXCL58XWS-CXCR2-CXCL5
31.58Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
31.58Single9EBIPiclidenoson9EBI-A3A-Piclidenoson-chim(NtGi1L-Gs-CtGi1)/β1/γ2
31.58Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
31.58Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
31.58Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
31.58Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
31.58Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
31.58Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
31.58Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
31.58Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
31.58Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
31.58Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
31.58Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
31.58Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
31.58Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
31.58Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
31.25Single2YDOAdenosine2YDO-A2A-Adenosine
31.25Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
31.25Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
31.25Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
31.25Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
31.25Single6PS0S-Carazolol6PS0-β2-S-Carazolol
31.25Single6PS4ICI118-5516PS4-β2-ICI118-551
31.25Single6PS5S-Propranolol6PS5-β2-S-Propranolol
31.25Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
31.25Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
31.25Single7T94LY21196207T94-M2-Acetylcholine-LY2119620-chim(NtGi1-Go)/β1/γ2
31.25Single7UTZDPPC7UTZ-TSH-TR1402-DPPC-Gs/β1/γ2
31.25Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.25Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.25Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
31.25Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
31.25Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
31.25Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
31.25Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
31.25Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
31.25Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
31.25Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
31.25Single8RLNLUF58348RLN-A2A-LUF5834
31.25Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.25Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.25Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
31.25Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
31.25Single8ZPNAMD31008ZPN-CXCR4-AMD3100
31.25Single9AS5Mescaline9AS5-5-HT2A-Mescaline
31.25Single9AS6Mescaline9AS6-5-HT2A-Mescaline-chim(NtGi1-Gs-CtGq)/β1/γ2
31.25Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
31.25Single9K0KUTP9K0K-P2Y4-UTP-chim(NtGi1-Gs-CtGq)/β1/γ2
31.25Single9K0XATP9K0X-P2Y2-ATP-chim(NtGi1-Gs-CtGq)/β1/γ2
31.25Single9K20ATP9K20-P2Y2-ATP-chim(NtGi1-Go)/β1/γ2
31.25Single9M2FNeuropeptide FF9M2F-NPFF1-Neuropeptide FF-Gi1/β1/γ2
31.25Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
31.25Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
31.25Consensusgrh_offOrthosteric Ligandgnrh1_off
30.77Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
30.77Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
30.77Single9EE9Adenosine9EE9-A2A-Adenosine-Gs/β1/γ2
30.77Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
30.43Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
30.43Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
30.43Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
30.43Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
30.43Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
30.43Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
30.43Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
30.43Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
30.43Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
30.43Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
30.43Single9U4WGonadoliberin-19U4W-GnRH1-Gonadoliberin-1-chim(NtGi1L-Gs-CtGq)/β1/γ2
30.43Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
30.43Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
30.43Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
30.43Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
30.43Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
30.00Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
30.00Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
30.00Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
30.00Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
30.00Single6IBLArformoterol6IBL-β1-Arformoterol
30.00Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
30.00Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
30.00Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
30.00Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
30.00Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
30.00Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
30.00Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
30.00Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-SBI-553-chim(NtGi1-Go)/β1/γ2
30.00Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
30.00Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
30.00Single8JPFNeurotensin8JPF-NTS1-Neurotensin-SBI-553
30.00Single8XWFCXCL38XWF-CXCR2-CXCL3
30.00Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
30.00Single8ZPLHF511168ZPL-CXCR4-HF51116
30.00Single8ZWGJR14a8ZWG-C3aB-JR14a-Gi1/β1/γ2
30.00Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
30.00Consensuscck_onOrthosteric Ligandccka_on cckb_on
30.00Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
30.00Consensuschemerin_onOrthosteric Ligandcml1_on
30.00Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
30.00Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
30.00Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
30.00Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
30.00Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
30.00Consensusprostanoid_offOrthosteric Ligandep_off dp_off
29.63Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
29.41Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
29.41Single2Y02Carmoterol2Y02-β1-Carmoterol
29.41Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
29.41Single3NY8ICI118-5513NY8-β2-ICI118-551
29.41Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
29.41Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
29.41Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
29.41Single4EJ4Naltrindole4EJ4-δ-Naltrindole
29.41Single4GBRS-Carazolol4GBR-β2-S-Carazolol
29.41Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
29.41Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
29.41Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
29.41Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
29.41Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
29.41Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
29.41Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
29.41Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
29.41Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
29.41Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
29.41Single7BU7BI1671077BU7-β1-BI167107
29.41Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
29.41Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
29.41Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
29.41Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
29.41Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
29.41Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
29.41Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
29.41Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
29.41Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
29.41Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
29.41Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
29.41Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
29.41Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
29.41Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
29.41Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
29.41Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
29.41Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.41Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.41Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.41Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.41Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.41Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.41Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.41Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.41Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.41Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.41Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
29.41Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
29.41Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
29.41Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
29.41Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
29.41Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
29.41Single8JJOAlprenolol8JJO-β2-Alprenolol
29.41Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
29.41Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.41Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.41Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.41Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.41Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
29.41Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
29.41Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
29.41Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
29.41Consensus5ht5_onOrthosteric Ligand5ht5a_on
29.41Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
29.41Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
29.41Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
29.41Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
29.41Consensusdopamine_offOrthosteric Ligandd2_off d3_off
29.41Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
29.41Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
29.41Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
29.17Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
29.17Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
29.17Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
29.17Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
29.17Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
29.17Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
29.17Single8ZBISomatostatin-148ZBI-SST3-Somatostatin-14-Gi1/β1/γ2
29.17Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
29.17Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
29.17Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
29.17Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
28.57Single3UZAGTPL92363UZA-A2A-GTPL9236
28.57Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
28.57Single6ME5Agomelatine6ME5-MT1-Agomelatine
28.57Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
28.57Single6PT3DPI-2876PT3-δ-DPI-287
28.57Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
28.57Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
28.57Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
28.57Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
28.57Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
28.57Single7XN9L-054,5227XN9-SST2-L-054,522
28.57Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
28.57Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
28.57Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
28.57Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
28.57Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
28.57Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
28.57Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
28.57Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
28.57Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
28.57Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
28.57Single8Y72Peptide8Y72-μ-Peptide-BMS-986122-Gi1/β1/γ2
28.57Single9CGKC5-Quino9CGK-δ-C5-Quino-Gi1/β1/γ2
28.57Single9IPVJR14a9IPV-C3aB-JR14a-Gi1/β1/γ2
28.57Single9M0RNeuropeptide VF9M0R-NPFF1-Neuropeptide VF-Gi1/β1/γ2
28.57Consensus5ht2_onOrthosteric Ligand5ht2b_on
28.57Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
28.57Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
28.57Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
28.57Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
28.57Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
28.57Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
28.57Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
28.57Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
28.57Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
28.57Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
28.57Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
28.12Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
28.12Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
28.00Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
28.00Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
28.00Single8ZRTET-18ZRT-ETB-ET-1
28.00Single9JFYhNPSF9JFY-NPFF2-hNPSF-Gi1/β1/γ2
28.00Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
27.78Single2RH1S-Carazolol2RH1-β2-S-Carazolol
27.78Single2YCWS-Carazolol2YCW-β1-S-Carazolol
27.78Single4NTJAZD12834NTJ-P2Y12-AZD1283
27.78Single5D6LS-Carazolol5D6L-β2-S-Carazolol
27.78Single5JQHS-Carazolol5JQH-β2-S-Carazolol
27.78Single5TVNLSD5TVN-5-HT2B-LSD
27.78Single5X7DS-Carazolol5X7D-β2-S-Carazolol-Cmpd-15
27.78Single6E67BI1671076E67-β2-BI167107-Gs(CT)
27.78Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
27.78Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
27.78Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
27.78Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
27.78Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
27.78Single6PS6Timolol6PS6-β2-Timolol
27.78Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
27.78Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
27.78Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
27.78Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
27.78Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
27.78Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
27.78Single7W41PD1762527W41-BB2-PD176252
27.78Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
27.78Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
27.78Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
27.78Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
27.78Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.78Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.78Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
27.78Single8TF5Oleic acid8TF5-GPR6-Oleic acid
27.78Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
27.78Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
27.78Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
27.78Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
27.78Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
27.78Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
27.78Single9F34FOB02-04A9F34-D3-FOB02-04A-Go/β1/γ2
27.78Single9I52A1IZU9I52-D1-A1IZU-Gs/β1/γ2
27.78Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
27.78Single9K07DSO-5a9K07-BB3-DSO-5a-chim(NtGi2L-Gs-CtGq)/β1/γ2
27.78Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
27.78Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
27.78Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
27.78Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
27.78Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
27.78Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
27.78Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
27.78Consensusamine_offonOrthosteric Ligandamine_off amine_on
27.78Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
27.78Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
27.78Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
27.78Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
27.78Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
27.78Consensusbombesin_offOrthosteric Ligandbb2_off
27.78Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
27.78Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
27.78Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
27.78Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
27.78Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
27.78Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
27.78Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
27.78Consensustrace-amine_onOrthosteric Ligandta1_on
27.59Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
27.59Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
27.59Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
27.59Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
27.27Single4XT1Fractalkine4XT1-US28-Fractalkine
27.27Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
27.27Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
27.27Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
27.27Single8U4OCXCL128U4O-CXCR4-CXCL12-Gi1/β1/γ2
27.27Single8WKYPG-9348WKY-MC4-PG-934
27.27Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
27.27Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
27.27Single8YWFRetatrutide8YWF-GLP-1-Retatrutide-chim(NtGi1-Gs)/β1/γ2
27.27Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
27.27Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
27.27Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
27.27Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
27.27Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
27.27Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
27.27Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
26.92Single4XT3Fractalkine4XT3-US28-Fractalkine
26.92Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
26.92Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
26.92Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
26.92Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
26.92Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
26.92Consensuspac_on_gpOrthosteric Ligandpac1_on_gp
26.67Single3PBLEticlopride3PBL-D3-Eticlopride
26.67Single4O9RCyclopamine4O9R-SMO-Cyclopamine
26.67Single5L7IVismodegib5L7I-SMO-Vismodegib
26.67Single6HLLCP999946HLL-NK1-CP99994
26.67Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
26.67Single7SRQLSD7SRQ-5-HT2B-LSD
26.67Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
26.67Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
26.67Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
26.67Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
26.67Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
26.67Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
26.67Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab
26.67Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
26.67Single9B9Y7DY9B9Y-CB1-7DY
26.67Single9E7RGB889E7R-PAR2-GB88-chim(NtGi1L-Gs-CtGq)/β1/γ2
26.67Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
26.67Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
26.67Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
26.67Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
26.67Consensusgq_nucleotideOrthosteric Ligandgq_p2y
26.67Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
26.67Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
26.32Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
26.32Single4BV0Neurotensin4BV0-NTS1-Neurotensin
26.32Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
26.32Single5D5AS-Carazolol5D5A-β2-S-Carazolol
26.32Single5D5BS-Carazolol5D5B-β2-S-Carazolol
26.32Single5V56TC1145V56-SMO-TC114
26.32Single5XRAAM115425XRA-CB1-AM11542
26.32Single6H7JIsoprenaline6H7J-β1-Isoprenaline
26.32Single6J21Aprepitant6J21-NK1-Aprepitant
26.32Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
26.32Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
26.32Single6WGTLSD6WGT-5-HT2A-LSD
26.32Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
26.32Single7B6WCyclazosin7B6W-α1b-Cyclazosin
26.32Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
26.32Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
26.32Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
26.32Single7FEECP559407FEE-CB1-CP55940-ZCZ011
26.32Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
26.32Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
26.32Single7R0CAVP7R0C-V2-AVP-Arrestin2
26.32Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
26.32Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
26.32Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
26.32Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
26.32Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
26.32Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
26.32Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
26.32Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
26.32Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
26.32Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
26.32Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
26.32Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
26.32Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
26.32Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
26.32Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
26.32Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
26.32Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
26.32Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
26.32Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
26.32Single9BJKNaloxone9BJK-μ-Naloxone-NAM
26.32Single9I54A1IZV9I54-D1-A1IZV-Gs/β1/γ2
26.32Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
26.32Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
26.32Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
26.32Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
26.32Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
26.32Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
26.32Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
26.32Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
26.32Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
26.32Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
26.32Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
26.32Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
26.32Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
26.32Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
26.32Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
26.32Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
26.32Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
26.09Single6HLOAprepitant6HLO-NK1-Aprepitant
26.09Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
26.09Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
26.09Single7SK5CXCL127SK5-ACKR3-CXCL12
26.09Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
26.09Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
26.09Single9E82SDF-1-beta9E82-ACKR3-SDF-1-β-Arrestin2
26.09Single9KFIRelaxin-39KFI-RXFP3-Relaxin-3-Gi2/β1/γ2
26.09Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
26.09Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
26.09Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
26.09Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
25.93Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
25.93Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
25.93Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
25.93Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
25.81Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
25.00Single3D4STimolol3D4S-β2-Timolol
25.00Single4AMIBucindolol4AMI-β1-Bucindolol
25.00Single4BWBNeurotensin4BWB-NTS1-Neurotensin
25.00Single4LDEBI1671074LDE-β2-BI167107
25.00Single4PY02MeSATP4PY0-P2Y12-2MeSATP
25.00Single4QINSAG1.54QIN-SMO-SAG1.5
25.00Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
25.00Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
25.00Single6AKXA4R6AKX-CCR5-A4R
25.00Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
25.00Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
25.00Single6DS0Ly2660976DS0-5-HT2B-Ly266097
25.00Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
25.00Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
25.00Single6KQICP559406KQI-CB1-CP55940-Org27569
25.00Single6ME2Ramelteon6ME2-MT1-Ramelteon
25.00Single6ME9Ramelteon6ME9-MT2-Ramelteon
25.00Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
25.00Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
25.00Single6PT2KGCHM076PT2-δ-KGCHM07
25.00Single6W25SHU91196W25-MC4-SHU9119-Ca
25.00Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
25.00Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
25.00Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
25.00Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
25.00Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
25.00Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
25.00Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
25.00Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
25.00Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
25.00Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
25.00Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
25.00Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
25.00Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
25.00Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
25.00Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
25.00Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
25.00Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
25.00Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
25.00Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
25.00Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
25.00Single7YITNalfurafine7YIT-κ-Nalfurafine
25.00Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
25.00Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
25.00Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
25.00Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
25.00Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
25.00Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
25.00Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
25.00Single8IWESpermidine8IWE-TA9-Spermidine
25.00Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
25.00Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
25.00Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
25.00Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
25.00Single8JWZAB9288JWZ-A2A-AB928-Na
25.00Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
25.00Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
25.00Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
25.00Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
25.00Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
25.00Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
25.00Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
25.00Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single8YYWAlpha-ketoglutarate8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
25.00Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
25.00Single9M1OMorphine-Modulating Neuropeptide B9M1O-NPFF2-Morphine-Modulating Neuropeptide B-Gi1/β1/γ2
25.00Single9M4QDoxazosin9M4Q-Alpha1A-Doxazosin
25.00Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
25.00Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
25.00Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
25.00Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
25.00Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
25.00Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
25.00Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
25.00Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
25.00Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
25.00Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
25.00Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
25.00Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
25.00Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
25.00Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
25.00Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
25.00Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
25.00Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
25.00Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
25.00Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
25.00Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
25.00Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
25.00Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
25.00Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
25.00Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
25.00Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
25.00Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
25.00Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
25.00Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
25.00Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
25.00Consensusorexin_onOrthosteric Ligandox2_on
25.00Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
24.14Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
24.14Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
24.14Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
24.14Consensusbombesin_onOrthosteric Ligandbb2_on
24.14Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
24.14Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
24.00Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
24.00Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
24.00Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
24.00Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
24.00Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
24.00Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
24.00Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
24.00Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
24.00Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ2
24.00Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
24.00Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
24.00Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
24.00Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
24.00Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
24.00Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
24.00Consensusvasop-oxy_onOrthosteric Ligandv2_on
24.00Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
23.81Single6H7LDobutamine6H7L-β1-Dobutamine
23.81Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
23.81Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
23.81Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
23.81Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
23.81Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
23.81Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
23.81Single7UM4AS26747237UM4-5-HT5A-AS2674723
23.81Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
23.81Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
23.81Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
23.81Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
23.81Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
23.81Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
23.81Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
23.81Single8S2TIsoprenaline8S2T-β1-Isoprenaline-chim(NtGi1-Gs)/β1/γ2
23.81Single8T3OTUG-8918T3O-FFA4-TUG-891-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.81Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
23.81Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
23.81Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
23.81Single9CGJC6-Quino9CGJ-δ-C6-Quino-Gi1/β1/γ2
23.81Single9M54Neuropeptide VF9M54-NPFF2-Neuropeptide VF-Gi1/β1/γ2
23.81Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
23.81Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
23.81Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
23.81Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
23.81Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
23.81Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
23.81Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
23.81Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
23.68Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
23.53Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
23.53Single4MBSMaraviroc4MBS-CCR5-Maraviroc
23.53Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
23.53Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
23.53Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
23.53Single6KUXRS-799486KUX-α2a-RS-79948
23.53Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
23.53Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
23.53Single6V9SGTPL114036V9S-OX1-GTPL11403
23.53Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
23.53Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
23.53Single6ZINSR486926ZIN-NTS1-SR48692
23.53Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
23.53Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
23.53Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
23.53Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
23.53Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
23.53Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
23.53Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
23.53Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
23.53Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
23.53Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
23.53Single7F61PF-036547467F61-H3-PF-03654746
23.53Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.53Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
23.53Single7UL3Famotidine7UL3-H2-Famotidine
23.53Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
23.53Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
23.53Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
23.53Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
23.53Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
23.53Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
23.53Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
23.53Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
23.53Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
23.53Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
23.53Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
23.53Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
23.53Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.53Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
23.53Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
23.53Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
23.53Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
23.53Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
23.53Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
23.53Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
23.53Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.53Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
23.53Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.53Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.53Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
23.53Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
23.53Single8Y6YGLPG09748Y6Y-FFA2-GLPG0974
23.53Single9AS3LSD9AS3-5-HT2A-LSD
23.53Single9AS4LSD9AS4-5-HT2A-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
23.53Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
23.53Single9BA0A1AKN9BA0-CB1-A1AKN
23.53Single9IXXLTD49IXX-CysLT2-LTD4-chim(NtGi1-Gs-CtGq)/β1/γ2
23.53Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Gi1/β1/γ2
23.53Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
23.53Consensusalpha1_onOrthosteric Ligandalpha1a_on
23.53Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
23.53Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
23.53Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
23.53Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
23.53Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
23.53Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
23.08Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
23.08Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
23.08Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
23.08Single7V68LY21196207V68-M4-Iperoxo-LY2119620-Gi1/β1/γ2
23.08Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
23.08Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
23.08Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
23.08Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
23.08Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
23.08Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
23.08Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
23.08Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
23.08Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
23.08Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
23.08Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
23.08Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
23.08Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
23.08Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
23.08Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
23.08Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
23.08Consensuspac_onOrthosteric Ligandpac1_on
23.08Consensusvpac_onOrthosteric Ligandvpac1_on vpac2_on
22.73Single5ZTYAM102575ZTY-CB2-AM10257
22.73Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
22.73Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
22.73Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
22.73Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
22.73Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
22.73Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
22.73Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
22.73Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
22.73Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
22.73Single9IPYJR14a9IPY-C3aB-JR14a
22.73Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
22.73Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
22.73Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
22.73Consensuskisspeptin_onOrthosteric Ligandkiss1_on
22.22Single2Y01Dobutamine2Y01-β1-Dobutamine
22.22Single2Y04Salbutamol2Y04-β1-Salbutamol
22.22Single4QKX35V4QKX-β2-35V
22.22Single5TGZAM65385TGZ-CB1-AM6538
22.22Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
22.22Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
22.22Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
22.22Single6H7MSalbutamol6H7M-β1-Salbutamol
22.22Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
22.22Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
22.22Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
22.22Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
22.22Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
22.22Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
22.22Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
22.22Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
22.22Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
22.22Single7SK3CXCL127SK3-ACKR3-CXCL12
22.22Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
22.22Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
22.22Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
22.22Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
22.22Single7UL4Alvimopan7UL4-μ-Alvimopan
22.22Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
22.22Single7V3ZCP559407V3Z-CB1-CP55940
22.22Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
22.22Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
22.22Single7WC7Lisuride7WC7-5-HT2A-Lisuride
22.22Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
22.22Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
22.22Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
22.22Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
22.22Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
22.22Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
22.22Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
22.22Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
22.22Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
22.22Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
22.22Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
22.22Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
22.22Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
22.22Single8JXRLSD8JXR-D1-LSD
22.22Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
22.22Single8PJKST1718PJK-5-HT1A-ST171-Gi1/β1/γ1
22.22Single8TH3AT118-H Nanobody8TH3-AT1-AT118-H Nanobody
22.22Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
22.22Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
22.22Single8X63Mepyramine8X63-H1-Mepyramine
22.22Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
22.22Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
22.22Single8ZYYNeurotensin peptide 8-138ZYY-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
22.22Single9AS1DMT9AS1-5-HT2A-DMT
22.22Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
22.22Single9IYAONO-97105319IYA-GPR55-ONO-9710531
22.22Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
22.22Single9PLNN-(5-methylnaphthalen-1-yl)pyridin-4-amine9PLN-α2a-N-(5-methylnaphthalen-1-yl)pyridin-4-amine
22.22Single9PLON-(5-methylnaphthalen-1-yl)pyridin-4-amine9PLO-α2a-N-(5-methylnaphthalen-1-yl)pyridin-4-amine-Go/β1/γ2
22.22Single9PQD(6m)-1-methyl-6-(1,2,5,6-tetrahydropyridin-3-yl)-1h-indole9PQD-α2a-(6m)-1-methyl-6-(1,2,5,6-tetrahydropyridin-3-yl)-1h-indole
22.22Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
22.22Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
22.22Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
22.22Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
22.22Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
22.22Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
22.22Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
22.22Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
22.22Consensusalpha2_onOrthosteric Ligandalpha2b_on
22.22Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
22.22Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
22.22Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
22.22Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
22.22Consensuscck_offOrthosteric Ligandccka_off
22.22Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
22.22Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
22.22Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
22.22Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
22.22Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
22.22Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
22.22Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
22.22Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
22.22Consensushistamine_offOrthosteric Ligandh1_off
22.22Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
22.22Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
22.22Consensusvpac_on_gpOrthosteric Ligandvpac1_on_gp vpac2_on_gp
21.88Consensusclass-a_class-b1_cons_on_gpOrthosteric Ligandclass-a_on_gp class-b1_on_gp
21.74Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
21.74Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
21.74Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
21.74Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
21.74Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
21.74Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
21.74Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
21.74Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
21.74Single8ZBJSomatostatin-148ZBJ-SST5-Somatostatin-14-Gi1/β1/γ2
21.74Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
21.74Single9HB3Mambaquaretin-19HB3-V2-Mambaquaretin-1
21.74Single9M4TSilodosin9M4T-Alpha1A-Silodosin
21.74Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
21.74Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
21.74Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
21.74Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
21.74Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
21.74Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
21.43Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
21.43Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
21.43Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
21.43Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
21.43Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
21.43Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
21.43Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
21.43Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
21.43Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
21.43Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
21.43Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
21.43Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.43Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
21.43Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
21.43Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Single9CHUNoradrenaline9CHU-β2-Noradrenaline
21.43Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
21.43Consensusglp_onOrthosteric Ligandglp1_on glp2_on
21.43Consensusglp_on_gpOrthosteric Ligandglp1_on_gp glp2_on_gp
21.05Single2Y00Dobutamine2Y00-β1-Dobutamine
21.05Single2Y03Isoprenaline2Y03-β1-Isoprenaline
21.05Single4JKVTaladegib4JKV-SMO-Taladegib
21.05Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
21.05Single5XPRBosentan5XPR-ETB-Bosentan
21.05Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
21.05Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
21.05Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
21.05Single6Z4SSR486926Z4S-NTS1-SR48692
21.05Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
21.05Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
21.05Single7SINNPS-21437SIN-CaS-NPS-2143
21.05Single7SINNPS-21437SIN-CaS-NPS-2143
21.05Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
21.05Single7WC6LSD7WC6-5-HT2A-LSD
21.05Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
21.05Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
21.05Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
21.05Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
21.05Single8JXSPF-61428JXS-D1-PF-6142
21.05Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
21.05Single8WGBVU01550418WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
21.05Single9ARYSerotonin9ARY-5-HT2A-Serotonin-chim(NtGi1-Gs-CtGq)/β1/γ2
21.05Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
21.05Single9B9ZA1AKO9B9Z-CB1-A1AKO
21.05Single9GE2ML1849GE2-GPR55-ML184-chim(NtGi1-G13)/β1/γ2
21.05Single9HAPTolvaptan9HAP-V2-Tolvaptan
21.05Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
21.05Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
21.05Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
21.05Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
21.05Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
21.05Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
21.05Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
21.05Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
21.05Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
21.05Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
21.05Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
21.05Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
21.05Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
20.83Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
20.83Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
20.83Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
20.83Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
20.83Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
20.83Single9IQVMuscarinic toxin 39IQV-Alpha1A-Muscarinic toxin 3
20.69Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
20.69Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
20.69Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
20.69Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
20.69Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
20.69Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
20.69Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
20.69Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
20.69Single9BYOExendin-39BYO-GLP-1-Exendin-3-Gs/β1/γ2
20.69Consensusvip-pacap_onOrthosteric Ligandvpac_on pac_on
20.69Consensusvip-pacap_on_gpOrthosteric Ligandvpac_on_gp pac_on_gp
20.00Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
20.00Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
20.00Single5TZRMK86665TZR-FFA1-MK8666
20.00Single5V57TC1145V57-SMO-TC114
20.00Single5XR8AM8415XR8-CB1-AM841
20.00Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
20.00Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
20.00Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
20.00Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
20.00Single6J20Aprepitant6J20-NK1-Aprepitant
20.00Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
20.00Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
20.00Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
20.00Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
20.00Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
20.00Single6TQ7SB-3348676TQ7-OX1-SB-334867
20.00Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
20.00Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
20.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
20.00Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
20.00Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
20.00Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
20.00Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
20.00Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
20.00Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
20.00Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
20.00Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
20.00Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
20.00Single7WC5Psilocin7WC5-5-HT2A-Psilocin
20.00Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
20.00Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
20.00Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
20.00Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
20.00Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
20.00Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
20.00Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
20.00Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
20.00Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
20.00Single8JPSCCL78JPS-ACKR1-CCL7
20.00Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
20.00Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
20.00Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
20.00Single8W8YGamma-MSH8W8Y-MC3-γ-MSH-Ca-Gs/β1/γ2
20.00Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
20.00Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
20.00Single8XVLZibotentan8XVL-ETA-Zibotentan
20.00Single8Y73Peptide8Y73-μ-Peptide-MPAM-15-Gi1/β1/γ2
20.00Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
20.00Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
20.00Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
20.00Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
20.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
20.00Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
20.00Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
20.00Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
20.00Single9IK9SST analogue9IK9-SST1-SST analogue-Gi1/β1/γ2
20.00Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
20.00Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
20.00Single9LRCHistamine9LRC-H4-Histamine
20.00Single9LREHistamine9LRE-H4-Histamine-Gi1/β1/γ2
20.00Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
20.00Consensusclass-a_class-b1_cons_onOrthosteric Ligandclass-a_on class-b1_on
20.00Consensusclass-b1_class-b2_cons_onOrthosteric Ligandclass-b1_on class-b2_on
20.00Consensusclass-b1_class-b2_cons_on_gpOrthosteric Ligandclass-b1_on_gp class-b2_on_gp
20.00Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
20.00Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
20.00Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
20.00Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
20.00Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
20.00Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
20.00Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
20.00Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
20.00Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
20.00Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
20.00Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
20.00Consensustachykinin_offOrthosteric Ligandnk1_off
19.35Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
19.35Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
19.35Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
19.35Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
19.35Consensusglp1_onOrthosteric Ligand7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
19.23Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
19.23Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
19.23Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
19.23Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
19.23Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
19.23Single9EBOGLP-1 (ACPC18)9EBO-GLP-1-GLP-1 (ACPC18)-Gs/β1/γ2
19.23Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
19.05Single4N4WSANT-14N4W-SMO-SANT-1
19.05Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
19.05Single5TZYMK8666; AP85TZY-FFA1-MK8666; AP8
19.05Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
19.05Single6A93Risperidone6A93-5-HT2A-Risperidone
19.05Single6CM4Risperidone6CM4-D2-Risperidone
19.05Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
19.05Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
19.05Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
19.05Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
19.05Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
19.05Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
19.05Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
19.05Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
19.05Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
19.05Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
19.05Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
19.05Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
19.05Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
19.05Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
19.05Single8Y6WTUG-13758Y6W-FFA2-TUG-1375-4-CMTB-Gi1/β1/γ2
19.05Single9GL2Befiradol9GL2-5-HT1A-Befiradol-Gs/β1/γ2
19.05Consensusalpha1_offOrthosteric Ligandalpha1a_off
19.05Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
19.05Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
19.05Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
19.05Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
19.05Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
19.05Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
19.05Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
19.05Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
18.75Single3OE9IT1t3OE9-CXCR4-IT1t
18.75Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
18.75Single6LI0C176LI0-GPR52-C17
18.75Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
18.75Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
18.75Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
18.75Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
18.75Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
18.75Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
18.75Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
18.75Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
18.75Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
18.75Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
18.75Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
18.75Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.75Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
18.75Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
18.75Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
18.75Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
18.75Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
18.75Single8K5BNiacin8K5B-HCA2-Niacin
18.75Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
18.75Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
18.75Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
18.75Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
18.75Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
18.75Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
18.75Single8YN7Immethridine8YN7-H3-Immethridine-Go/β1/γ2
18.75Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
18.75Single9AS2DMT9AS2-5-HT2A-DMT-chim(NtGi1-Gs-CtGq)/β1/γ2
18.75Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
18.75Single9IXJHistamine9IXJ-H2-Histamine-Gs/β1/γ2
18.75Consensuscrf_on_gpOrthosteric Ligandcrf2_on_gp crf1_on_gp
18.75Consensusglp1_on_gpOrthosteric Ligand7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
18.52Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
18.52Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
18.52Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
18.52Consensusvpac1_onOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
18.18Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
18.18Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
18.18Single5X93K-87945X93-ETB-K-8794
18.18Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
18.18Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
18.18Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
18.18Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
18.18Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
18.18Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.18Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
18.18Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
18.18Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
18.18Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
18.18Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
18.18Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
18.18Single9AS02-bromo-LSD9AS0-5-HT2A-2-bromo-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Single9C0KExendin-49C0K-GLP-1-Exendin-4-Gs/β1/γ2
18.18Single9DYEBuspirone9DYE-5-HT1A-Buspirone-Go/β1/γ2
18.18Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
18.18Consensusendothelin_offOrthosteric Ligandetb_off
18.18Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
18.18Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.18Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.18Consensusglucagon_onOrthosteric Ligandglp_on gluc_on secretin_on gip_on
17.86Single6FJ3PTH6FJ3-PTH1-PTH
17.86Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
17.86Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
17.86Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
17.86Single9BLBCagrilintide backbone (non-acylated)9BLB-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
17.86Single9BLWCagrilintide backbone (non-acylated)9BLW-CT (AMY1)-Cagrilintide backbone (non-acylated)-Gs/β1/γ2; RAMP1
17.86Single9KFKRelaxin-39KFK-RXFP4-Relaxin-3-Gi2/β1/γ2
17.86Consensuspac1_onOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
17.86Consensuspac1_on_gpOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
17.86Consensusvpac1_on_gpOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
17.65Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
17.65Single4S0VSuvorexant4S0V-OX2-Suvorexant
17.65Single5U09Taranabant5U09-CB1-Taranabant
17.65Single5WS3EMPA5WS3-OX2-EMPA
17.65Single6AKYMaraviroc6AKY-CCR5-Maraviroc
17.65Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
17.65Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
17.65Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
17.65Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
17.65Single6TODEMPA6TOD-OX1-EMPA-Na
17.65Single6TPJSuvorexant6TPJ-OX2-Suvorexant
17.65Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
17.65Single7F8YDevazepide7F8Y-CCKA-Devazepide
17.65Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
17.65Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
17.65Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
17.65Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
17.65Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
17.65Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
17.65Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
17.65Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
17.65Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
17.65Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
17.65Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
17.65Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
17.65Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
17.65Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
17.65Single7XRRLemborexant7XRR-OX2-Lemborexant
17.65Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
17.65Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
17.65Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
17.65Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
17.65Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
17.65Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
17.65Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
17.65Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
17.65Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
17.65Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
17.65Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
17.65Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ2
17.65Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
17.65Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
17.65Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
17.65Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
17.65Single9K6LSA09K6L-TAS2R16-SA0-Gi2/β1/γ2
17.65Single9KPESA09KPE-TAS2R16-SA0-Gi1/β1/γ2
17.65Single9LRBHistamine9LRB-H1-Histamine-Gs/β1/γ2
17.65Consensusangiotensin_offOrthosteric Ligandat1_off
17.65Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
17.65Consensusglucagon_on_gpOrthosteric Ligandglp_on_gp gluc_on_gp secretin_on_gp gip_on_gp
17.65Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
17.65Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
17.65Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
17.65Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
17.65Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
17.65Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
17.65Consensusorexin_offOrthosteric Ligandox2_off ox1_off
17.65Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
17.65Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
17.65Consensuspth_onOrthosteric Ligandpth1_on pth2_on
17.65Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
17.65Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
17.65Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
17.65Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
17.65Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
17.65Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
17.39Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
17.39Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
17.39Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
17.39Single8X5YAstemizole8X5Y-H1-Astemizole
17.39Single9JH6C20:0 Ceramide9JH6-CysLT2-C20:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Single9MD1Buspirone9MD1-5-HT1A-Buspirone-Gz/β1/γ2
17.24Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
17.24Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
17.24Single8W8XBeta-MSH8W8X-MC3-β-MSH-Ca-Gs/β1/γ2
17.24Single9BUCCagrilintide9BUC-CT-Cagrilintide-Gs/β1/γ2
16.67Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
16.67Single3RZECidoxepin3RZE-H1-Cidoxepin
16.67Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
16.67Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
16.67Single4ZJCSB-6740424ZJC-OX1-SB-674042
16.67Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
16.67Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
16.67Single6A94Zotepine6A94-5-HT2A-Zotepine
16.67Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
16.67Single6IQLL7458706IQL-D4-L745870
16.67Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
16.67Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
16.67Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
16.67Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
16.67Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
16.67Single6TP3Nemorexant6TP3-OX1-Nemorexant
16.67Single6TPGEMPA6TPG-OX2-EMPA
16.67Single6TPNHTL66416TPN-OX2-HTL6641
16.67Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
16.67Single6VI4JDTic6VI4-κ-JDTic
16.67Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
16.67Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
16.67Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
16.67Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
16.67Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
16.67Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
16.67Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
16.67Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
16.67Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
16.67Single7T94Acetylcholine7T94-M2-Acetylcholine-LY2119620-chim(NtGi1-Go)/β1/γ2
16.67Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
16.67Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
16.67Single7VV6C48/807VV6-MRGPRX2-C48/80
16.67Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
16.67Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
16.67Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
16.67Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
16.67Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
16.67Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single8IEBA1LYA8IEB-GPR156-A1LYA
16.67Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
16.67Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
16.67Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
16.67Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
16.67Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
16.67Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
16.67Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
16.67Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
16.67Single8K5CAcipimox8K5C-HCA2-Acipimox
16.67Single8K9LDamgo8K9L-μ-Damgo-BMS-986122-Gi3/β1/γ1
16.67Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
16.67Single8PKMBefiradol8PKM-5-HT1A-Befiradol-Gi1/β1/γ1
16.67Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
16.67Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
16.67Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
16.67Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
16.67Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
16.67Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
16.67Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
16.67Single8ZPMAMD0708ZPM-CXCR4-AMD070
16.67Single9ARXSerotonin9ARX-5-HT2A-Serotonin
16.67Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single9BUECagrilintide9BUE-CT-Cagrilintide-Gs/β1/γ2
16.67Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
16.67Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
16.67Single9KPDSA09KPD-TAS2R16-SA0-chim(Gs-CtGt3)/β1/γ2
16.67Single9LRDHistamine9LRD-H1-Histamine-Gi1/β1/γ2
16.67Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
16.67Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
16.67Consensusclass-b1_onOrthosteric Ligandglucagon_on vip-pacap_on pth_on crf_on calcitonin_on
16.67Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
16.67Consensushca_onOrthosteric Ligandhca2_on
16.67Consensusopsins_offOrthosteric Ligandrhodopsin_off
16.67Consensuspth1_onOrthosteric Ligand6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
16.67Consensuspth2_on_gpOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
16.67Consensussensory_offOrthosteric Ligandopsins_off
16.67Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
16.67Consensusvpac2_on_gpOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
16.13Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
16.13Single7RBTTirzepatide7RBT-GIP-Tirzepatide-LSN3556672-chim(NtGi1-Gs)/β1/γ2
16.13Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
16.13Consensuscrf1_onOrthosteric Ligand6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF1-Corticoliberin-Gs/β1/γ2
16.13Consensusgip_onOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
16.13Consensusgip_on_gpOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
16.00Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
16.00Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
16.00Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
16.00Single7XNACYN1548067XNA-SST2-CYN154806
16.00Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
16.00Single9IK8SST analogue9IK8-SST1-SST analogue-Gi1/β1/γ2
16.00Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
16.00Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
15.79Single4DAJTiotropium4DAJ-M3-Tiotropium
15.79Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
15.79Single4MQSIperoxo4MQS-M2-Iperoxo
15.79Single4U14Tiotropium4U14-M3-Tiotropium
15.79Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
15.79Single4YAYZD-71554YAY-AT1-ZD-7155
15.79Single5DHHSB-6121115DHH-NOP-SB-612111
15.79Single5DSGTiotropium5DSG-M4-Tiotropium
15.79Single5T04Neurotensin5T04-NTS1-Neurotensin
15.79Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
15.79Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
15.79Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
15.79Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
15.79Single6DRXLisuride6DRX-5-HT2B-Lisuride
15.79Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
15.79Single6TOTLemborexant6TOT-OX1-Lemborexant
15.79Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
15.79Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
15.79Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
15.79Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
15.79Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
15.79Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
15.79Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
15.79Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
15.79Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
15.79Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
15.79Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
15.79Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
15.79Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
15.79Single8T1WCVN4248T1W-GPR6-CVN424
15.79Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
15.79Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
15.79Single8X64Desloratadine8X64-H1-Desloratadine
15.79Single8YN8Proxyfan8YN8-H3-Proxyfan-Go/β1/γ2
15.79Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
15.79Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
15.79Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
15.79Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
15.79Single9JEAAtropine9JEA-M1-Atropine
15.79Single9JGKBalovaptan9JGK-5-HT2B-Balovaptan
15.79Single9KFJPubChem 1383196749KFJ-RXFP3-PubChem 138319674-Gi2/β1/γ2
15.79Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
15.79Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
15.79Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
15.79Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
15.79Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
15.79Consensushca_on_gpOrthosteric Ligandhca2_on_gp
15.79Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
15.79Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
15.79Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
15.79Consensuspth_on_gpOrthosteric Ligandpth1_on_gp pth2_on_gp
15.38Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
15.38Single8GEJConstrained Epinephrine8GEJ-β2-Constrained Epinephrine-Gs/β1/γ2
15.38Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
15.15Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.15Consensuscrf1_on_gpOrthosteric Ligand6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF1-Corticoliberin-Gs/β1/γ2
15.15Consensuspth1_on_gpOrthosteric Ligand6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
15.00Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
15.00Single5WIUNemonapride5WIU-D4-Nemonapride
15.00Single5WIVNemonapride5WIV-D4-Nemonapride-Na
15.00Single5WQCEMPA5WQC-OX2-EMPA
15.00Single6HLPNetupitant6HLP-NK1-Netupitant
15.00Single6LUQHaloperidol6LUQ-D2-Haloperidol
15.00Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
15.00Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
15.00Single6TP6Filorexant6TP6-OX1-Filorexant
15.00Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
15.00Single7C4SS1P7C4S-S1P3-S1P
15.00Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
15.00Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
15.00Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
15.00Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
15.00Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
15.00Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.00Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
15.00Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.00Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
15.00Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
15.00Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
15.00Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
15.00Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
15.00Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
15.00Single8XYKVUF106618XYK-CXCR3-VUF10661-Go/β1/γ2
15.00Single8ZMFA1L108ZMF-5-HT2C-A1L10
15.00Single9ARZ2-bromo-LSD9ARZ-5-HT2A-2-bromo-LSD
15.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
15.00Single9CIBFCH-22964139CIB-HCA2-FCH-2296413
15.00Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
15.00Single9DYDAsenapine9DYD-5-HT1A-Asenapine-Go/β1/γ2
15.00Single9DYFAsenapine9DYF-5-HT1A-Asenapine-Gi1/β1/γ2
15.00Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
15.00Single9F33FOB02-04A9F33-D3-FOB02-04A-Go/β1/γ2
15.00Single9KPFSA09KPF-TAS2R16-SA0-Gi1/β1/γ2
15.00Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
15.00Consensusclass-b1_on_gpOrthosteric Ligandglucagon_on_gp vip-pacap_on_gp pth_on_gp crf_on_gp calcitonin_on_gp
15.00Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
15.00Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
15.00Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
15.00Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.00Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.00Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
15.00Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
15.00Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
14.81Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
14.81Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
14.81Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
14.81Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
14.81Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
14.81Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
14.81Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
14.81Single9BLCCagrilintide backbone (non-acylated)9BLC-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
14.81Single9BUDCagrilintide9BUD-CT-Cagrilintide-Gs/β1/γ2
14.81Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
14.71Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
14.71Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
14.71Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
14.71Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
14.29Single4DJHJDTic4DJH-κ-JDTic
14.29Single4U15Tiotropium4U15-M3-Tiotropium
14.29Single5V54Methiothepin5V54-5-HT1B-Methiothepin
14.29Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
14.29Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
14.29Single6E59L-7607356E59-NK1-L-760735
14.29Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
14.29Single6OL9Tiotropium6OL9-M5-Tiotropium
14.29Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
14.29Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
14.29Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
14.29Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
14.29Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
14.29Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
14.29Single7WC4Serotonin7WC4-5-HT2A-Serotonin
14.29Single7XKDBeta-Hydroxyandrosterone7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
14.29Single8EA0Iperoxo8EA0-M3-Iperoxo
14.29Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
14.29Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
14.29Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
14.29Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
14.29Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
14.29Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
14.29Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
14.29Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
14.29Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
14.29Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
14.29Single9EGOYVF9EGO-CB1-YVF-Gi1/β1/γ2
14.29Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
14.29Consensus5ht1_offOrthosteric Ligand5ht1b_off
14.29Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
14.29Consensuscalcitonin_onOrthosteric Ligandctlike_on
14.29Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
14.29Consensusgluc_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
14.29Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
14.29Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
14.29Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
14.29Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
14.29Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
14.29Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
14.29Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
14.29Consensusrelaxin_onOrthosteric Ligandrxfp4_on
14.29Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
13.89Consensusgluc_on_gpOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
13.79Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
13.79Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
13.79Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
13.79Single9BP3Cagrilintide9BP3-CT (AMY1)-Cagrilintide-Gs/β1/γ2; RAMP1
13.79Single9BUBCagrilintide9BUB-CT-Cagrilintide-Gs/β1/γ2
13.79Consensuscalcitonin_on_gpOrthosteric Ligandctlike_on_gp
13.79Consensuscrf2_on_gpOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
13.79Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
13.79Consensussecretin_onOrthosteric Ligand7D3S-Secretin-Secretin-Gs/β1/γ2
13.64Single5CXVTiotropium5CXV-M1-Tiotropium
13.64Single6ZG4HTL00099366ZG4-M1-HTL0009936
13.64Single7DFPSpiperone7DFP-D2-Spiperone
13.64Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
13.64Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
13.64Single7K15MKD0467K15-BLT1-MKD046-Na
13.64Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
13.64Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
13.64Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
13.64Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.64Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
13.64Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
13.64Single8JD3JNJ-404118138JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
13.64Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
13.64Single8XYIVUF106618XYI-CXCR3-VUF10661
13.64Single9CM3TUG-13759CM3-FFA2-TUG-1375-Compound 187-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.64Single9DGIZ85267113509DGI-CB1-Z8526711350
13.64Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
13.33Single6OY9All-trans-Retinal6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
13.33Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
13.33Single6XBM5LWE6XBM-SMO-5LWE-Gi1/β1/γ2
13.33Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
13.33Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
13.33Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
13.33Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
13.33Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
13.33Single8IWM2-Phenylethylamine8IWM-TA9-2-Phenylethylamine
13.33Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Gi1/β1/γ2
13.33Single8W8WAlpha-MSH8W8W-MC3-α-MSH-Ca-Gs/β1/γ2
13.33Single8WC5Tetramethylammonium Ion8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
13.33Single8Y02Retinal8Y02-OPN1SW-Retinal-Gi1/β1/γ2
13.33Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
13.33Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
13.33Consensusglp2_on_gpOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
13.33Consensusgs_histamineOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
13.33Consensush2_onOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
13.33Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
13.33Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
13.33Consensussecretin_on_gpOrthosteric Ligand7D3S-Secretin-Secretin-Gs/β1/γ2
13.33Consensussensory_onOrthosteric Ligandopsins_on
13.04Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
13.04Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
13.04Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
13.04Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
13.04Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
13.04Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
13.04Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
13.04Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
13.04Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
13.04Single8XVJMacitentan8XVJ-ETA-Macitentan
13.04Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
13.04Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
13.04Consensusfp-alpha_onOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
13.04Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
12.90Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
12.90Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
12.90Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
12.90Single9BTWCagrilintide9BTW-CT (AMY3)-Cagrilintide-Gs/β1/γ2; RAMP3
12.90Consensusctlike_on_gpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
12.50Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
12.50Single3OE6IT1t3OE6-CXCR4-IT1t
12.50Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
12.50Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Single7SK9CCX6627SK9-ACKR3-CCX662
12.50Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
12.50Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single8IW72-Phenylethylamine8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
12.50Single8J6QCompound 9n8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
12.50Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
12.50Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
12.50Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
12.50Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
12.50Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
12.50Single9CM7TUG-13759CM7-FFA2-TUG-1375-AZ-1729-Gi1/β1/γ2
12.50Single9IZASCH9002719IZA-HCA2-SCH900271-Gi1/β1/γ2
12.50Single9JF4PD1683689JF4-BB1-PD168368
12.50Single9JHJC18:0 Ceramide9JHJ-FPR2-ALX-C18:0 Ceramide-Gi1/β1/γ2
12.50Single9NS9TUG-13759NS9-FFA2-TUG-1375-Compound 187-Gi1/β1/γ2
12.50Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
12.50Consensusgi_sensoryOrthosteric Ligandgi_opsins
12.50Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
12.50Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
12.50Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
12.50Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
12.50Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
12.50Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
12.12Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
12.12Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
12.12Single9AUCCalcitonin gene-related peptide-19AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
12.00Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
12.00Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
12.00Single8KIGSHU91198KIG-MC3-SHU9119-Ca
12.00Consensussomatostatin_offOrthosteric Ligandsst2_off
11.76Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
11.76Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
11.76Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
11.76Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
11.76Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
11.76Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
11.76Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
11.76Single6TP4ACT-4622066TP4-OX1-ACT-462206
11.76Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
11.76Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
11.76Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.76Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
11.76Single7UL2SR486927UL2-NTS1-SR48692-Na
11.76Single7V68Iperoxo7V68-M4-Iperoxo-LY2119620-Gi1/β1/γ2
11.76Single7XP6Strychnine7XP6-TAS2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
11.76Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
11.76Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
11.76Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
11.76Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
11.76Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/β1/γ2
11.76Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
11.76Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.76Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
11.76Single8YN2Histamine8YN2-H1-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
11.76Single8ZYUNeurotensin peptide 8-138ZYU-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
11.76Single9AS7Psilocin9AS7-5-HT2A-Psilocin
11.76Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
11.76Single9EPRRetinal9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
11.76Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
11.76Single9LMPNE52-QQ579LMP-GPR4-NE52-QQ57
11.76Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg4_on
11.76Consensusadgrg_on_gpOrthosteric Ligandadgrg2_on_gp adgrg4_on_gp
11.76Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
11.76Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
11.76Consensusneurotensin_offOrthosteric Ligandnts1_off
11.76Consensusnts1_offOrthosteric Ligand7UL2-NTS1-SR48692-Na
11.54Single8IEBA1LYA8IEB-GPR156-A1LYA
11.54Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
11.43Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
11.11Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
11.11Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
11.11Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
11.11Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
11.11Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
11.11Single3ODUIT1t3ODU-CXCR4-IT1t
11.11Single5ZKQABT-4915ZKQ-PAF-ABT-491
11.11Single6B73MP11046B73-κ-MP1104
11.11Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
11.11Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
11.11Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
11.11Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
11.11Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
11.11Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
11.11Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
11.11Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
11.11Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
11.11Single8T3VDocosa-4,7,10,13,16,19-Hexaenoic acid8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.11Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
11.11Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
11.11Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
11.11Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
11.11Single8Y0HVUF114188Y0H-CXCR3-VUF11418
11.11Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go/β1/γ2
11.11Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
11.11Single9B5YLong-Acting PTH9B5Y-PTH1-Long-Acting PTH-chim(NtGi1-Gq)/β1/γ2
11.11Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
11.11Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
10.71Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
10.71Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
10.53Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
10.53Single6TPKRetosiban6TPK-OT-Retosiban
10.53Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
10.53Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
10.53Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
10.53Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
10.53Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.53Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
10.53Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
10.53Single8IHKAcifran8IHK-HCA3-Acifran
10.53Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
10.53Single8K2WAMG4878K2W-CXCR3-AMG487
10.53Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.53Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
10.53Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
10.53Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
10.53Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
10.53Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
10.53Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
10.53Single9JFUNE52-QQ579JFU-GPR4-NE52-QQ57
10.53Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
10.53Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
10.53Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
10.53Consensusvasop-oxy_offOrthosteric Ligandot_off
10.26Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
10.00Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
10.00Single5DHGC-355DHG-NOP-C-35
10.00Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
10.00Single6GPSMK08126GPS-CCR2-MK0812
10.00Single6IIVDaltroban6IIV-TXA2-Daltroban
10.00Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.00Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
10.00Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
10.00Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
10.00Single7YXAONO-54306087YXA-S1P5-ONO-5430608
10.00Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
10.00Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
10.00Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
10.00Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
10.00Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
10.00Single8K5DGSK2560738K5D-HCA2-GSK256073
10.00Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
10.00Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
10.00Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
10.00Single9IMATalquetamab9IMA-GPRC5D-Talquetamab
10.00Single9IZCMK19039IZC-HCA2-MK1903-Gi1/β1/γ2
10.00Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
10.00Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
10.00Consensusblt_onOrthosteric Ligandblt1_on
10.00Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
10.00Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
10.00Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
10.00Consensusleukotriene_onOrthosteric Ligandblt_on
10.00Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
9.68Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
9.52Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
9.52Single5CGCHTL142425CGC-mGlu5-HTL14242
9.52Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
9.52Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
9.52Single6GPXMK08126GPX-CCR2-MK0812
9.52Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
9.52Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
9.52Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
9.52Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
9.52Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
9.52Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
9.52Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
9.52Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
9.52Single9HC04YI9HC0-mGlu5-4YI
9.52Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
9.52Consensusblt_offOrthosteric Ligandblt1_off
9.52Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
9.52Consensusep_offOrthosteric Ligandep4_off
9.38Single9BQ3Cagrilintide9BQ3-CT (AMY2)-Cagrilintide-Gs/β1/γ2; RAMP2
9.09Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
9.09Single6D35Cholesterol6D35-SMO-Cholesterol
9.09Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
9.09Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
9.09Single6UO8SKF975416UO8-GABAB1, GABAB2-SKF97541-GS39783
9.09Single6UO9SKF975416UO9-GABAB1, GABAB2-SKF97541
9.09Single6W2XPubChem 53110426W2X-GABAB1, GABAB2-PubChem 5311042
9.09Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042
9.09Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042
9.09Single7C7QBaclofen7C7Q-GABAB1, GABAB2-Baclofen-BHFF
9.09Single7C7SCGP546267C7S-GABAB1, GABAB2-CGP54626
9.09Single7CUMCGP546267CUM-GABAB1, GABAB2-CGP54626
9.09Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
9.09Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
9.09Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
9.09Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
9.09Single7DGEQuisqualate7DGE-mGlu1; mGlu1-Quisqualate
9.09Single7DTTCa7DTT-CaS-Ca-Ca
9.09Single7DTTCa7DTT-CaS-Ca-Ca
9.09Single7DTUTryptophan7DTU-CaS-Tryptophan
9.09Single7DTUTryptophan7DTU-CaS-Tryptophan
9.09Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
9.09Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
9.09Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
9.09Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
9.09Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
9.09Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
9.09Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
9.09Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
9.09Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
9.09Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
9.09Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
9.09Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
9.09Single7EB2Baclofen7EB2-GABAB2; GABAB1-Baclofen-rac-BHFF-Gi1/β1/γ2
9.09Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
9.09Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
9.09Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
9.09Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
9.09Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
9.09Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
9.09Single7FIHhCG7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
9.09Single7FIIhCG7FII-LH-hCG-chim(NtGi1-Gs)/β1/γ2
9.09Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
9.09Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
9.09Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
9.09Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
9.09Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
9.09Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
9.09Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
9.09Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
9.09Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
9.09Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
9.09Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
9.09Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
9.09Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
9.09Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
9.09Single7P2L4YI7P2L-mGlu5-4YI
9.09Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
9.09Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
9.09Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
9.09Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
9.09Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
9.09Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
9.09Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
9.09Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
9.09Single7T9NM22 Fab7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
9.09Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
9.09Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
9.09Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
9.09Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
9.09Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
9.09Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
9.09Single7XW6M22 Fab7XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
9.09Single7XW7K1-707XW7-TSH-K1-70
9.09Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
9.09Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
9.09Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
9.09Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
9.09Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
9.09Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
9.09Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
9.09Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
9.09Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
9.09Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
9.09Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
9.09Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
9.09Single8JD0Glutamate8JD0-mGlu2; mGlu3-Glutamate-NAM563
9.09Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
9.09Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
9.09Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
9.09Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
9.09Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
9.09Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
9.09Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
9.09Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
9.09Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
9.09Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
9.09Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
9.09Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
9.09Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
9.09Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
9.09Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
9.09Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
9.09Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
9.09Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
9.09Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
9.09Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
9.09Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
9.09Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
9.09Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
9.09Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
9.09Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
9.09Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
9.09Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
9.09Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
9.09Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
9.09Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
9.09Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
9.09Single8WG9(2S)-2-amino-4-phosphonobutanoic acid8WG9-mGlu4; mGlu2-(2S)-2-amino-4-phosphonobutanoic acid
9.09Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
9.09Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
9.09Single8WGCLY3792688WGC-mGlu4; mGlu2-LY379268
9.09Single8WGDWAG; WA68WGD-mGlu4; mGlu2-WAG; WA6
9.09Single8WGDWAG; WA68WGD-mGlu4; mGlu2-WAG; WA6
9.09Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
9.09Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
9.09Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.09Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.09Single8WVXNorrin8WVX-LGR4-Norrin
9.09Single8WVYNorrin8WVY-LGR4-Norrin
9.09Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
9.09Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
9.09Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
9.09Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
9.09Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
9.09Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
9.09Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
9.09Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
9.09Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
9.09Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
9.09Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
9.09Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
9.09Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
9.09Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
9.09Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
9.09Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
9.09Single8XUMR-spondin-28XUM-LGR4-R-spondin-2
9.09Single8ZW0PGD28ZW0-DP1-PGD2-Gs/β1/γ2
9.09Single9AS9RS130-1809AS9-5-HT2A-RS130-180
9.09Single9ASARS130-1809ASA-5-HT2A-RS130-180-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
9.09Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
9.09Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
9.09Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
9.09Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
9.09Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
9.09Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
9.09Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
9.09Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
9.09Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
9.09Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
9.09Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
9.09Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
9.09Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
9.09Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
9.09Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
9.09Single9CLWTUG-13759CLW-FFA2-TUG-1375-4-CMTB-chim(NtGi1L-Gs-CtGq)/β1/γ2
9.09Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
9.09Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
9.09Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
9.09Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
9.09Single9KHHNorrin9KHH-LGR4-Norrin
9.09Single9S37NB219S37-LGR4-NB21
9.09Single9UTBSucralose9UTB-TAS1R2; TAS1R3-Sucralose
8.70Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
8.70Single6IIURamatroban6IIU-TXA2-Ramatroban
8.70Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
8.70Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
8.70Single8XJNCloprosetnol8XJN-TXA2-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
8.70Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
8.70Single9GGGI-BOP9GGG-TXA2-I-BOP-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.33Single5CGDHTL142425CGD-mGlu5-HTL14242
8.33Single6K1QIRL25006K1Q-ETB-IRL2500
8.33Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
8.33Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
8.33Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
8.33Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
8.33Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
8.33Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
8.33Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
8.33Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
8.33Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
8.33Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
8.33Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
8.33Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
8.33Single8XJOU466198XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
8.33Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
8.33Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
8.33Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
8.33Single9JH5C16:0 Ceramide9JH5-CysLT2-C16:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Single9M1HProstaglandin E29M1H-EP1-Prostaglandin E2-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Consensusclass-b2_onOrthosteric Ligandadgrg_on adgrf_on adgrl_on adgre_on adgrd_on
8.33Consensusclass-b2_on_gpOrthosteric Ligandadgrg_on_gp adgrf_on_gp adgrl_on_gp adgre_on_gp adgrd_on_gp
8.33Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
8.33Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
8.33Consensustp_onOrthosteric Ligand8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Consensustp_on_gpOrthosteric Ligand8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
8.00Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
8.00Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
8.00Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
8.00Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
7.69Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
7.69Single7KNUCalcitonin gene-related peptide-17KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
7.69Single7QA8Peptide7QA8-STE2-Peptide
7.69Single7QA8Peptide7QA8-STE2-Peptide
7.69Single7T9MCS-17 Antibody7T9M-TSH-CS-17 Antibody
7.69Single8IEIA1LYA8IEI-GPR156-A1LYA
7.69Single8IEIA1LYA8IEI-GPR156-A1LYA
7.69Single8IEPA1LYA8IEP-GPR156-A1LYA
7.69Single8IEPA1LYA8IEP-GPR156-A1LYA
7.69Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
7.69Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
7.41Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
7.14Single4A4MAll-trans-Retinal4A4M-Rhodopsin-All-trans-Retinal-Gt(CT)
7.14Single5EN0All-trans-Retinal5EN0-Rhodopsin-All-trans-Retinal-Gt(CT)
7.14Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
7.14Single7FIGhCG7FIG-LH-hCG-chim(NtGi1L-Gs)/β1/γ2
7.14Single7UTZTR14027UTZ-TSH-TR1402-DPPC-Gs/β1/γ2
7.14Single7XW5TSH7XW5-TSH-TSH-ML109-Gs/β1/γ2
7.14Single7ZI0Cholesterol7ZI0-SMO-SAG-Cholesterol
7.14Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/β1/γ2
6.90Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
6.67Single3PXOAll-trans-Retinal3PXO-Rhodopsin-All-trans-Retinal
6.67Single5DYSAll-trans-Retinal5DYS-Rhodopsin-All-trans-Retinal
6.67Single5L7DCholesterol5L7D-SMO-Cholesterol
6.67Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
6.67Single7T9ITSH7T9I-TSH-TSH-Gs/β1/γ2
6.67Single8HS2Fab0468HS2-GPR20-Fab046
6.67Single8I2GGlycoprotein hormones alpha chain8I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
6.67Single8X9S5alpha-DHT8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
6.45Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
6.25Single2HPYAll-trans-Retinal2HPY-Rhodopsin-All-trans-Retinal
6.25Single3OE8IT1t3OE8-CXCR4-IT1t
6.25Single6TQ9SB-4081246TQ9-OX1-SB-408124
6.25Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
6.25Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
6.25Single7Y14Beta-Alanine7Y14-MRGPRD-β-Alanine
6.06Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
5.88Single3PQRAll-trans-Retinal3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
5.88Single7Y12Beta-Alanine7Y12-MRGPRD-β-Alanine-Gi1/β1/γ2
5.88Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
5.56Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
5.56Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
5.56Single8HSCFab0468HSC-GPR20-Fab046-Gi1/β1/γ2
5.56Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
5.56Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
5.56Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
5.26Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
5.26Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
5.26Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.26Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.00Single6FFIMMPEP6FFI-mGlu5-MMPEP
5.00Single6ZG9GSK10347026ZG9-M1-GSK1034702
5.00Single7VODCariprazine7VOD-5-HT2A-Cariprazine
5.00Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single8IYXYL-3658IYX-GPR34-YL-365
5.00Single8YRGFospropofol8YRG-MRGPRX4-Fospropofol-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Single6FFHFenobam6FFH-mGlu5-Fenobam
4.76Single7F83PF-051904577F83-Ghrelin-PF-05190457
4.76Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
4.76Single9IVGGLP-1 (Truncated)9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
4.76Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
4.76Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
4.55Single5T1ABMS-6815T1A-CCR2-BMS-681-PubChem 12093170
4.55Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
4.55Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
4.55Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
4.55Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
4.55Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
4.55Single8ZVZBW245C8ZVZ-DP1-BW245C-Gs/β1/γ2
4.55Consensusadgrg2_onOrthosteric Ligand7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
4.55Consensusadgrg2_on_gpOrthosteric Ligand7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
4.35Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
4.35Single8GDBPGE28GDB-EP4-PGE2-Gs/β1/γ2
4.35Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35Single8JD5JNJ-40411813; ADX881788JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
4.35Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
4.35Single8YNTSNAP-948478YNT-MCH1-SNAP-94847
4.17Single5X33BIIL2605X33-BLT1-BIIL260
4.17Single9AU0BW245C9AU0-DP1-BW245C-Gs/β1/γ2
4.17Single9BJKNAM9BJK-μ-Naloxone-NAM
4.00Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
4.00Single9GG5U466199GG5-TXA2-U46619-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.85Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
3.70Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
3.70Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
3.70Single8XFTR-spondin-28XFT-LGR4-R-spondin-2-ZNRF3
3.70Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-ZNRF3
3.45Single8WVUR-spondin-18WVU-LGR4-R-spondin-1-RNF43
3.45Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-ZNRF3
3.33Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
3.33Single8XFPR-spondin-28XFP-LGR4-R-spondin-2-ZNRF3
3.03Single8XFSR-spondin-28XFS-LGR4-R-spondin-2-ZNRF3

Consensus Members
Id Members
nucleotide_on_gp adenosine_on_gp
p2y_on_gp
nucleotide_off adenosine_off
p2y_off
Net Summary
Imin 3.27362
Number of Linked Nodes 950
Number of Links 971
Number of Hubs 106
Number of Links mediated by Hubs 456
Number of Communities 11
Number of Nodes involved in Communities 49
Number of Links involved in Communities 57
Path Summary
Number Of Nodes in MetaPath 96
Number Of Links MetaPath 95
Number of Shortest Paths 228046
Length Of Smallest Path 3
Average Path Length 42.5839
Length of Longest Path 92
Minimum Path Strength 0.714287
Average Path Strength 4.07969
Maximum Path Strength 14.8328
Minimum Path Correlation 0.703686
Average Path Correlation 0.908464
Maximum Path Correlation 0.987244
Minimum % Of Corr. Nodes 1.13636
Average % Of Corr. Nodes 16.8224
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 34.1327
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .




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