Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
2x563x328.99751NoNo7721
2x567x424.083751NoYes7721
3x327x429.170831NoYes7711
3x32Lig13.3691NoYes7010
3x334x573.937080NoNo6712
3x33Lig9.711870NoYes6010
3x366x486.946670NoYes6812
3x36Lig7.774580NoYes6010
3x375x4617.559580NoNo6621
E2E244.83171YesYes3322
E2E2x525.746671YesNo3421
5x39E27.896461NoYes7322
E2x52Lig10.0851NoYes4010
5x395x438.081041NoNo7621
5x43Lig6.0850NoYes6010
5x446x523.876040NoYes6721
5x461Lig4.117710NoYes6010
5x476x5218.17251YesYes7721
6x486x526.82751YesYes8721
6x516x527.279581YesYes7711
6x517x344.295621YesNo7412
6x517x373.451461YesYes7512
6x517x3811.70771YesNo7611
6x51Lig11.54651YesYes7010
6x52Lig5.981041YesYes7010
6x557x343.771041YesNo6412
6x55Lig3.661881YesYes6010
7x387x428.470421NoYes6711
7x38Lig14.72131NoYes6010
7x397x425.206250YesYes6721
7x42Lig6.623541YesYes7010
2x577x425.179370NoYes7721
6x516x555.666251YesYes7611
5x406x553.543750NoYes6621

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Consensus Members
Id Members
beta_on beta1_on
beta2_on
beta3_on
alpha_on alpha1_on
alpha2_on
Net Summary
Imin 3.38188
Number of Linked Nodes 271
Number of Links 294
Number of Hubs 36
Number of Links mediated by Hubs 157
Number of Communities 5
Number of Nodes involved in Communities 40
Number of Links involved in Communities 55
Path Summary
Number Of Nodes in MetaPath 46
Number Of Links MetaPath 45
Number of Shortest Paths 62972
Length Of Smallest Path 3
Average Path Length 13.7595
Length of Longest Path 30
Minimum Path Strength 0.316458
Average Path Strength 5.5321
Maximum Path Strength 12.9583
Minimum Path Correlation 0.700208
Average Path Correlation 0.888712
Maximum Path Correlation 0.986042
Minimum % Of Corr. Nodes 3.7037
Average % Of Corr. Nodes 38.9969
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 46.4367
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following differences:
Id1st Network2nd Network
adrenergic_off_onadrenergic_offadrenergic_on
This network is also present in following consensuses:
IdComponents
amine_onadrenergic_on
histamine_on
muscarinic_on
tar_on
5ht_on
dopamine_on



You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download adrenergic_on.zip



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