Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
1NT 12.7875414
21x35 4.1625406
31x39 4.86407
41x56 6.174117
51x60 6.04254115
6I1 9.17875836
72x39 6.535477
82x42 4.85507
92x53 8.29407
102x57 3.9825407
112x63 9.384515
122x64 7.344515
13E1 8.588514
14E1x50 7.37833618
15E1x52 4.1275417
163x28 5.08414
173x29 9.275415
183x42 6.6925127
193x43 4.4875408
203x46 5.4025478
213x49 9.285478
223x50 9.3825479
233x51 7.69754177
24I2x51 4.4625405
254x50 7.414129
26E2 22.31311313
27E2x50 9.2025419
28E2x52 8.98516
295x36 9.7175414
305x39 9.57405
315x58 6.931676169
32I3 5.85683
336x31 7.02686
346x48 7.7508
356x49 5.034195
366x52 9.1875408
376x54 2.6225405
386x55 5.526506
396x62 8.5875415
406x63 4.1475413
41E3 8.00143712
427x34 7.40333614
437x35 8.93515
447x38 8.08415
457x53 6.26479
467x54 3.8365116
47G.HN.11 2.11402
48G.HN.43 5.3625408
49G.hns1.02 5.2425403
50G.S1.06 5.9475458
51G.H1.01 4.355459
52G.H1.04 10.8675457
53G.H1.07 3.7675409
54G.H1.12 5.8025408
55G.S2.04 7.938556
56G.S3.03 4.505407
57G.S3.04 9.515407
58G.S3.05 5.9125457
59G.S3.07 5.576559
60G.H2.05 9.6275427
61G.H2.06 7.03167629
62G.H2.07 6.28857729
63G.h2s4.01 7.634529
64G.S4.03 5.87458
65G.S4.04 7.3475409
66G.s4h3.04 8.192508
67G.H3.15 3.522508
68G.H3.17 7.404525
69G.H3.18 5.0725409
70G.S5.05 6.854559
71G.s5hg.01 3.8625409
72G.hgh4.05 6.665406
73G.S6.02 7.30833688
74G.S6.05 7.0254215
75G.H5.03 7.336558
76G.H5.15 3.5325188
77G.H5.17 6.56485
78G.H5.23 8.24674
79b.1x3 5.76754221
80b.lhb1x11 4.3975434
81b.b1x3 4.8475437
82b.l1x3 6.265699
83b.l1x6 7.685429
84b.b2x1 9.52528
85b.b2x5 9.5275407
86b.l3x2 7.72409
87b.b4x5 5.364137
88b.b4x6 8.84799
89b.l4x2 9.0525434
90b.b5x3 7.614599
91b.b5x5 5.445135
92b.l5x5 7.73143729
93b.b6x5 4.7275406
94b.b7x1 7.9475404
95b.b8x4 6.468506
96b.l9x3 10.01254109
97b.l9x6 6.65571728
98b.b10x5 5.285409
99b.l10x1 4.23754273
100b.b11x1 6.59254275
101b.b11x5 5.5975466
102b.l11x2 6.2554109
103b.b12x3 4.4775468
104b.b12x6 10.6445108
105b.l12x1 4.6475406
106b.b13x7 7.784567
107b.l13x3 7.9725469
108b.l13x7 5.8175469
109b.l15x1 7.215427
110b.l15x2 7.5575409
111b.b16x4 6.962566
112b.b16x6 9.222568
113b.b17x5 5.906547
114b.b17x7 9.2275448
115b.l17x3 8.36857749
116b.l17x6 10.715429
117b.l18x2 5.66754147
118b.b19x2 9.7725446
119b.l19x1 5.45429
120b.l19x2 8.33409
121b.b20x2 6.2175406
122b.b20x4 10.37408
123b.b20x6 7.942546
124b.l20x2 6.84409
125b.b21x2 5.1654236
126b.b21x7 5.178505
127b.l21x5 4.34254154
128b.b22x4 3.75405
129b.l22x5 8.264299
130b.b23x2 6.055406
131b.b23x6 6.9645157
132b.l23x2 5.73754158
133b.b24x6 7.35408
134b.l24x3 5.145405
135b.l25x3 14.9025439
136b.l25x6 13.1725428
137b.b27x5 7.7975439
138b.l27x1 10.7475829
139b.l27x2 10.15439
140b.b28x4 10.7975436
141b.b28x6 9.096539
142b.b28x7 6.755439
143g.ctx3 5.516509
144g.ctx4 5.0225407
145g.ctx6 3.0675406
146g.ctx14 6.7325439
147g.ctx15 7.5475439
148g.ctx16 6.36889938
149Lig 12.0862810
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
17x34 7x35 12.78445.64YesYes145
23x43 6x45 56.60213.65YesNo089
36x45 6x48 56.45488.25NoYes098
46x48 6x52 53.06244.36YesYes088
56x51 6x52 38.180710.18NoYes078
66x51 7x34 37.55044.13NoYes074
72x40 I1 95.95712.36NoYes376
82x37 2x40 95.84773.26NoNo077
92x37 G.H5.22 95.62857.19NoNo074
102x39 G.H5.22 39.98074.1YesNo774
112x39 3x46 38.7994.42YesYes778
123x46 7x53 38.00166.04YesYes789
133x43 7x53 66.50684.69YesYes089
14G.H5.22 G.H5.23 55.5388.98NoYes744
153x50 G.H5.23 53.72826.17YesYes794
163x50 7x53 39.42329.26YesYes799
17I1 b.l25x4 99.27245.53YesNo365
187x38 E2x52 10.81823.57YesYes156
197x34 7x38 18.326914.4YesYes145
203x50 G.H5.25 17.140314.58YesNo098
21G.H5.20 G.H5.25 16.97295.54NoNo088
226x31 G.H5.20 15.40764.86YesNo868
236x31 G.H5.13 11.90965.96YesNo868
24b.l25x4 b.l27x2 99.37795.32NoYes359
25b.l25x3 b.l27x2 99.648713.87YesYes399
26b.b27x3 b.l25x3 50.05584.11NoYes089
27b.b27x3 b.b28x6 50.08296.06NoYes089
28b.b28x6 b.lhb1x11 1003.49YesYes394
29b.b28x7 b.lhb1x11 77.89174.21YesYes394
30b.b28x7 g.ctx16 76.90866.04YesYes398
31b.l4x1 g.ctx16 75.10066.61NoYes358
32b.b2x5 b.l4x1 75.26654.94YesNo075
33b.b2x5 b.b3x2 76.868715.94YesNo075
34b.b3x2 b.b4x6 76.81953.42NoYes059
35b.b4x6 b.l1x3 73.2316.35YesYes999
36b.b28x4 b.l25x3 50.153724.89YesYes369
37b.b28x4 b.b28x6 50.15885.8YesYes369
385x44 6x55 13.06166.01NoYes056
396x41 7x53 10.85725.05NoYes079
40b.l1x3 b.l1x7 71.77147.95YesNo099
41b.b26x2 b.l1x7 71.71254.91NoNo079
42b.b26x1 b.b26x2 73.02033.44NoNo097
43b.b26x1 b.l27x1 72.96413.71NoYes099
44b.b2x1 b.l27x1 67.728317.36YesYes289
45G.H3.17 b.l27x1 10.63565.62YesYes259
46G.H3.15 G.H3.17 20.96133.86YesYes085
47G.H3.12 G.H3.15 19.28673.63NoYes088
48G.H3.12 G.S4.04 18.46593.77NoYes089
49b.lhb1x11 g.ctx5 22.65944.24YesNo049
50b.b23x1 g.ctx5 14.81344.15NoNo059
51b.b23x1 b.b24x5 14.7754.47NoNo055
52b.b24x5 b.b25x5 12.83251.84NoNo054
53b.b25x5 b.b25x6 12.77321.84NoNo043
54b.b24x2 b.b25x6 12.72024.43NoNo053
55b.b24x2 b.l23x2 12.63558.08NoYes058
56b.l21x7 b.l23x2 14.17514.67NoYes1558
57b.l21x7 b.l21x8 17.07993.92NoNo054
58b.l21x8 b.l23x1 17.02963.35NoNo046
59b.l23x1 b.l25x6 16.871823.82NoYes268
60G.H3.17 b.l25x6 10.42516YesYes258
61G.H3.09 G.S4.04 21.38158.57NoYes099
62G.H3.09 G.h4s6.01 18.15833.65NoNo094
63G.H3.06 G.h4s6.01 17.64565.64NoNo064
64G.H3.03 G.H3.06 17.37898.1NoNo046
65G.H3.03 G.s4h3.15 17.1123.94NoNo049
66G.hgh4.02 G.s4h3.15 16.8453.62NoNo089
67G.HG.15 G.hgh4.02 16.31064.87NoNo078
68G.HG.15 G.s4h3.04 12.55275.86NoYes078
69G.H2.10 b.b2x1 64.83885.38NoYes278
70G.H2.10 b.b6x1 65.08724.86NoNo079
71b.b6x1 b.l9x6 60.9925.99NoYes098
72G.H2.07 b.l9x6 11.61148.68YesYes298
73G.H2.06 b.l9x6 62.50863.58YesYes298
74G.H2.06 b.l19x1 63.45244.15YesYes299
75b.l17x5 b.l19x1 63.60552.94NoYes069
76b.l17x5 b.l19x2 63.48175.89NoYes069
77b.l17x4 b.l19x2 18.080414.29NoYes039
78b.l17x3 b.l17x4 17.93463.69YesNo093
79b.b19x4 b.l17x3 25.98658.21NoYes489
80b.b19x4 b.b20x6 25.53067.78NoYes486
81b.b17x7 b.b20x6 46.581111.79YesYes486
82b.b17x5 b.b17x7 44.45127.03YesYes478
83b.b17x5 b.b21x1 35.79747.83YesNo477
84b.1x19 b.b21x1 33.63029.53NoNo467
85b.1x15 b.1x19 32.54987.52NoNo076
86b.1x14 b.1x15 30.3845.49NoNo047
87b.1x11 b.1x14 28.21755.32NoNo084
88b.1x11 g.h1x12 20.63042.82NoNo086
89g.h1x12 g.h1x8 19.54593.04NoNo067
90b.1x4 g.h1x8 17.37658.94NoNo087
91b.b19x6 b.l19x2 18.08047.36NoYes099
92b.b19x6 b.l17x3 17.934613.95NoYes099
93b.b20x2 b.l19x2 27.19795.78YesYes069
94b.b20x2 b.l17x3 17.94369.58YesYes069
95b.b20x4 b.l17x3 26.45112.41YesYes089
96b.b20x4 b.b20x6 34.04217.48YesYes086
97g.ctx3 g.ctx5 11.6895.43YesNo099
98b.b19x2 b.b20x6 10.83289.65YesYes466
995x44 6x52 13.37634.11NoYes058
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
E3NT16.871YesYes2422
E2NT4.821YesYes3412
1x322x644.130NoYes3521
1x32E13.890NoYes3422
1x327x3113.410NoNo3421
1x352x643.520YesYes6521
1x357x353.990YesYes6522
2x603x299.720NoYes7521
2x632x6414.891YesYes5511
2x63E14.991YesYes5412
2x63E1x5011.581YesYes5812
2x63E2x506.721YesYes5912
2x63Lig8.741YesYes5010
2x647x386.171YesYes5512
2x64Lig8.011YesYes5010
E1E1x4911.061YesNo4522
E1E26.211YesYes4321
E1x49E211.521NoYes5321
3x25E1x507.841NoYes9822
E1x50E2x5013.061YesYes8922
3x22E210.351NoYes3321
3x25E23.381NoYes9321
3x25E2x507.281NoYes9922
3x29E2x509.751YesYes5912
3x29E2x5213.11YesYes5611
3x29Lig4.531YesYes5010
3x33E2x523.780NoYes5621
4x64E23.711NoYes5321
E2E273.771YesYes3311
E2E2x5133.41YesNo3411
E2Lig29.411YesYes3010
E2x51Lig10.191NoYes4010
E2E2x5210.121YesYes3611
7x38E2x523.571YesYes5621
E2x52Lig14.331YesYes6010
5x36E222.481YesYes4321
5x33E27.131NoYes4321
5x336x623.641NoYes4521
6x586x629.640NoYes4521
6x62E310.511YesYes5212
6x62Lig10.561YesYes5010
E3E35.181YesYes2222
7x317x3519.160NoYes4512
7x31Lig10.920NoYes4010
7x357x388.181YesYes5522

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Consensusgq_nucleotideOrthosteric Ligandgq_p2y
88.89Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
80.00Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
80.00Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
54.55Single8YYWAlpha-ketoglutarate8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
50.00Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
50.00Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
50.00Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
50.00Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
46.67Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
46.67Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
46.67Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
46.15Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
46.15Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
46.15Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
46.15Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
45.45Single3OE9IT1t3OE9-CXCR4-IT1t
45.45Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
44.44Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
43.75Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
43.75Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
41.67Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
41.18Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
41.18Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
41.18Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
40.00Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
40.00Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
40.00Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
40.00Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
38.89Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
38.46Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
38.46Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
38.46Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
38.46Single9JMDAzithromycin9JMD-Motilin-Azithromycin-chim(Gs-CtGq)/β1/γ2
38.46Consensushca_onOrthosteric Ligandhca2_on
37.50Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
37.50Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
37.50Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
37.50Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
37.50Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
37.50Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
37.50Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
37.50Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
36.84Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
36.36Single3OE6IT1t3OE6-CXCR4-IT1t
36.36Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
35.71Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
35.71Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
35.71Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
35.71Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
35.71Single8K5DGSK2560738K5D-HCA2-GSK256073
35.71Single9IZCMK19039IZC-HCA2-MK1903-Gi1/β1/γ2
35.71Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
35.71Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
35.71Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
35.71Consensushca_on_gpOrthosteric Ligandhca2_on_gp
35.29Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
35.29Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
35.29Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
35.29Single8ZPLHF511168ZPL-CXCR4-HF51116
35.29Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
35.29Consensusprostanoid_offOrthosteric Ligandep_off dp_off
33.33Single6D26Fevipiprant6D26-DP2-Fevipiprant
33.33Single6JODAngiotensin II6JOD-AT2-Angiotensin II
33.33Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
33.33Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
33.33Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
33.33Single9CIBFCH-22964139CIB-HCA2-FCH-2296413
33.33Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
33.33Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
33.33Single9LMPNE52-QQ579LMP-GPR4-NE52-QQ57
33.33Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
33.33Consensusdp_offOrthosteric Liganddp2_off
33.33Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
33.33Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
31.82Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
31.82Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
31.82Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
31.82Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
31.58Single4XT1Fractalkine4XT1-US28-Fractalkine
31.58Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
31.58Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
31.58Single8U4OCXCL128U4O-CXCR4-CXCL12-Gi1/β1/γ2
31.58Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
31.58Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
31.25Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
31.25Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
31.25Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
31.25Single9UY3Anamorelin9UY3-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
31.25Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
31.25Consensusrelaxin_onOrthosteric Ligandrxfp4_on
31.25Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
30.77Single3ODUIT1t3ODU-CXCR4-IT1t
30.77Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
30.77Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
30.77Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
30.77Single8GNGIstradefylline8GNG-A2A-Istradefylline
30.77Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
30.77Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
30.77Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
30.77Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
30.77Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
30.77Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
30.43Single4XT3Fractalkine4XT3-US28-Fractalkine
30.43Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
30.00Single7XNACYN1548067XNA-SST2-CYN154806
30.00Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
30.00Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
30.00Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
30.00Single9E82SDF-1-beta9E82-ACKR3-SDF-1-β-Arrestin2
30.00Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
30.00Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
30.00Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
30.00Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
29.41Single4XEENeurotensin4XEE-NTS1-Neurotensin
29.41Single4XESNeurotensin4XES-NTS1-Neurotensin
29.41Single6OS2TRV0266OS2-AT1-TRV026
29.41Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
29.41Single6YVRNTS8-136YVR-NTS1-NTS8-13
29.41Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
29.41Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
29.41Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
29.41Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
29.41Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
29.41Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
29.17Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
29.17Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
29.17Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
29.17Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
28.57Single3OE0CVX153OE0-CXCR4-CVX15
28.57Single6MH8ZM-2413856MH8-A2A-ZM-241385
28.57Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
28.57Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
28.57Single7T94LY21196207T94-M2-Acetylcholine-LY2119620-chim(NtGi1-Go)/β1/γ2
28.57Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
28.57Single8IHKAcifran8IHK-HCA3-Acifran
28.57Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
28.57Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
28.57Single8K5CAcipimox8K5C-HCA2-Acipimox
28.57Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
28.57Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
28.57Single9JFUNE52-QQ579JFU-GPR4-NE52-QQ57
28.57Single9K0XATP9K0X-P2Y2-ATP-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Single9K20ATP9K20-P2Y2-ATP-chim(NtGi1-Go)/β1/γ2
28.57Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
28.57Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
28.57Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
27.78Single4BUONeurotensin4BUO-NTS1-Neurotensin
27.78Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
27.78Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
27.78Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
27.78Consensuscck_onOrthosteric Ligandccka_on cckb_on
27.78Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
27.78Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
27.78Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
27.78Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
27.78Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
27.27Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
27.27Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
27.27Single8ZBISomatostatin-148ZBI-SST3-Somatostatin-14-Gi1/β1/γ2
27.27Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
27.27Consensusp2y_offOrthosteric Ligandp2y1_off
27.27Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
26.92Single6IGKEndothelin-36IGK-ETB-Endothelin-3
26.67Single6D27CAY104716D27-DP2-CAY10471
26.67Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/β1/γ2
26.67Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
26.67Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
26.67Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
26.67Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
26.67Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
26.67Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
26.67Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
26.67Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
26.67Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
26.67Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
26.67Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
26.67Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
26.67Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
26.67Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
26.67Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
26.32Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
26.32Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
26.32Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
26.32Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
26.32Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
26.32Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
26.32Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
26.32Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
26.32Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
26.32Single9IZASCH9002719IZA-HCA2-SCH900271-Gi1/β1/γ2
26.32Single9M0RNeuropeptide VF9M0R-NPFF1-Neuropeptide VF-Gi1/β1/γ2
26.32Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
26.32Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
26.09Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
26.09Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
26.09Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
26.09Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
26.09Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
26.09Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
26.09Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
26.09Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
26.09Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
26.09Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
25.00Single4XNWMRS25004XNW-P2Y1-MRS2500
25.00Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
25.00Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
25.00Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
25.00Single6ME5Agomelatine6ME5-MT1-Agomelatine
25.00Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
25.00Single7F8XNN90567F8X-CCKA-NN9056
25.00Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
25.00Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
25.00Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
25.00Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
25.00Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
25.00Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
25.00Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
25.00Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
25.00Single8XWNCXCL88XWN-CXCR2-CXCL8
25.00Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
25.00Single8ZBJSomatostatin-148ZBJ-SST5-Somatostatin-14-Gi1/β1/γ2
25.00Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
25.00Single9EHSLUF76029EHS-A3A-LUF7602
25.00Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
25.00Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
25.00Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
25.00Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
25.00Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
25.00Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
25.00Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
25.00Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
25.00Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
25.00Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
25.00Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
25.00Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
25.00Consensussomatostatin_offOrthosteric Ligandsst2_off
25.00Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
24.00Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
24.00Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
24.00Single9KDFRES-701-39KDF-ETB-RES-701-3
24.00Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
24.00Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
23.81Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
23.81Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
23.81Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
23.81Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
23.81Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
23.81Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
23.81Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
23.81Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
23.81Single9IQSMuscarinic toxin 39IQS-M4-Muscarinic toxin 3
23.81Single9IQVMuscarinic toxin 39IQV-Alpha1A-Muscarinic toxin 3
23.81Single9J0FNADH9J0F-P2Y14-NADH-Gi1/β1/γ2
23.81Single9KFIRelaxin-39KFI-RXFP3-Relaxin-3-Gi2/β1/γ2
23.81Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
23.81Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
23.81Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
23.81Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
23.81Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
23.53Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
23.53Single6OS1TRV0266OS1-AT1-TRV026
23.53Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
23.53Single7B6WCyclazosin7B6W-α1b-Cyclazosin
23.53Single7F1TMIP-1a7F1T-CCR5-MIP-1a
23.53Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
23.53Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
23.53Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
23.53Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
23.53Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
23.53Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.53Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
23.53Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
23.53Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
23.53Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
23.53Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
23.53Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
23.53Consensusneurotensin_onOrthosteric Ligandnts1_on
23.53Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
23.08Single6IGLIRL16206IGL-ETB-IRL1620
23.08Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
23.08Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
23.08Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
23.08Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
23.08Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
23.08Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
23.08Single8K5BNiacin8K5B-HCA2-Niacin
23.08Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
23.08Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
23.08Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
23.08Single9E7RGB889E7R-PAR2-GB88-chim(NtGi1L-Gs-CtGq)/β1/γ2
23.08Single9IZDCHBA9IZD-HCA1-CHBA-Gi1/β1/γ2
22.73Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
22.73Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
22.73Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
22.73Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
22.73Consensusangiotensin_onOrthosteric Ligandat1_on
22.73Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
22.73Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
22.73Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
22.73Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
22.73Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
22.73Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
22.73Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
22.73Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
22.73Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
22.73Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
22.22Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
22.22Single5GLHEndothelin-15GLH-ETB-Endothelin-1
22.22Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
22.22Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
22.22Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
22.22Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
22.22Single7K15MKD0467K15-BLT1-MKD046-Na
22.22Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
22.22Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
22.22Single8JWY2-1188JWY-A2A-2-118
22.22Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
22.22Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
22.22Single8XWACXCL18XWA-CXCR2-CXCL1
22.22Single8XWMCXCL68XWM-CXCR2-CXCL6
22.22Single8XWSCXCL58XWS-CXCR2-CXCL5
22.22Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
22.22Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
22.22Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
22.22Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
22.22Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
22.22Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
22.22Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
22.22Consensusbombesin_onOrthosteric Ligandbb2_on
22.22Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
22.22Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
22.22Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
22.22Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
22.22Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
22.22Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
21.74Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
21.74Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
21.74Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
21.74Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
21.74Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
21.74Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
21.74Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
21.74Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
21.74Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
21.74Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
21.74Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
21.74Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
21.74Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
21.74Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
21.74Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
21.74Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
21.43Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
21.43Single3PWHZM-2413853PWH-A2A-ZM-241385
21.43Single4BWBNeurotensin4BWB-NTS1-Neurotensin
21.43Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
21.43Single5ZKQABT-4915ZKQ-PAF-ABT-491
21.43Single6ME9Ramelteon6ME9-MT2-Ramelteon
21.43Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
21.43Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
21.43Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
21.43Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
21.43Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
21.43Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
21.43Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
21.43Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
21.43Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
21.43Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
21.43Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
21.43Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
21.43Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
21.43Single8YYWAlpha-ketoglutarate8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
21.43Single9H2XA1IR19H2X-A2A-A1IR1-Na
21.43Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
21.43Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
21.43Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
21.43Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
21.43Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
21.05Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
21.05Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
21.05Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
21.05Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
21.05Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-SBI-553-chim(NtGi1-Go)/β1/γ2
21.05Single8JPFNeurotensin8JPF-NTS1-Neurotensin-SBI-553
21.05Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
21.05Single8XVUCXCL28XVU-CXCR2-CXCL2
21.05Single8XWFCXCL38XWF-CXCR2-CXCL3
21.05Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
21.05Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
21.05Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
21.05Consensuschemerin_onOrthosteric Ligandcml1_on
21.05Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
21.05Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
20.83Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
20.83Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
20.83Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
20.83Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.83Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
20.83Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
20.83Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
20.69Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
20.00Single3REYXAC3REY-A2A-XAC
20.00Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
20.00Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
20.00Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
20.00Single5UVIZM-2413855UVI-A2A-ZM-241385
20.00Single6KNMJN241-96KNM-Apelin-JN241-9
20.00Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
20.00Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
20.00Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
20.00Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
20.00Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
20.00Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
20.00Single7AROLUF58337ARO-A2A-LUF5833-Na
20.00Single7F61PF-036547467F61-H3-PF-03654746
20.00Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
20.00Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
20.00Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
20.00Single7SK3CXCL127SK3-ACKR3-CXCL12
20.00Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
20.00Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
20.00Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
20.00Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
20.00Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
20.00Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
20.00Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
20.00Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
20.00Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
20.00Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
20.00Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
20.00Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
20.00Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
20.00Single8ZPMAMD0708ZPM-CXCR4-AMD070
20.00Single9K0KUTP9K0K-P2Y4-UTP-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single9M2FNeuropeptide FF9M2F-NPFF1-Neuropeptide FF-Gi1/β1/γ2
20.00Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
20.00Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
20.00Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
20.00Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
20.00Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
20.00Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
20.00Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
20.00Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
20.00Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
19.23Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
19.23Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
19.23Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
19.05Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
19.05Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
19.05Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
19.05Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
19.05Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
19.05Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
19.05Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
19.05Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
19.05Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
19.05Single8WDTphotoNECA8WDT-A2A-photoNECA
19.05Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
19.05Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
19.05Single9BUYLM1899BUY-β2-LM189-Gi1/β1/γ2
19.05Single9HB3Mambaquaretin-19HB3-V2-Mambaquaretin-1
19.05Single9J0IUDP-Glucuronic acid9J0I-P2Y14-UDP-Glucuronic acid-Gi1/β1/γ2
19.05Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
19.05Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
19.05Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
19.05Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
19.05Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
19.05Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
19.05Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
19.05Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
19.05Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
18.75Single3EMLZM-2413853EML-A2A-ZM-241385
18.75Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
18.75Single4QIMANTA XV4QIM-SMO-ANTA XV
18.75Single4YAYZD-71554YAY-AT1-ZD-7155
18.75Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
18.75Single5T04Neurotensin5T04-NTS1-Neurotensin
18.75Single5UIGCmpd-15UIG-A2A-Cmpd-1
18.75Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
18.75Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
18.75Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
18.75Single6S0LZM-2413856S0L-A2A-ZM-241385
18.75Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
18.75Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
18.75Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
18.75Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
18.75Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
18.75Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
18.75Single7V3ZCP559407V3Z-CB1-CP55940
18.75Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
18.75Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
18.75Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
18.75Single8CU6LJ-45178CU6-A2A-LJ-4517
18.75Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
18.75Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
18.75Single8PJKST1718PJK-5-HT1A-ST171-Gi1/β1/γ1
18.75Single8TH3AT118-H Nanobody8TH3-AT1-AT118-H Nanobody
18.75Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
18.75Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
18.75Single8ZYYNeurotensin peptide 8-138ZYY-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
18.75Single9H37A1IR09H37-A2A-A1IR0-Na
18.75Single9IYAONO-97105319IYA-GPR55-ONO-9710531
18.75Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
18.52Single8IY6Endothelin-18IY6-ETB-Endothelin-1
18.52Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
18.52Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
18.52Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
18.52Consensusbradykinin_onOrthosteric Ligandbk2_on
18.52Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
18.52Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
18.52Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
18.18Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
18.18Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
18.18Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
18.18Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
18.18Single7SK5CXCL127SK5-ACKR3-CXCL12
18.18Single7V68LY21196207V68-M4-Iperoxo-LY2119620-Gi1/β1/γ2
18.18Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
18.18Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
18.18Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
18.18Single8PWNTheophylline8PWN-A2A-Theophylline
18.18Single9IK8SST analogue9IK8-SST1-SST analogue-Gi1/β1/γ2
18.18Single9IQRMuscarinic toxin 39IQR-α2a-Muscarinic toxin 3
18.18Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
18.18Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
18.18Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
17.86Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
17.86Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
17.65Single4JKVTaladegib4JKV-SMO-Taladegib
17.65Single5IUAQ274563485IUA-A2A-Q27456348-Na
17.65Single5N2SPSB365N2S-A1-PSB36
17.65Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
17.65Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
17.65Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
17.65Single6S0QZM-2413856S0Q-A2A-ZM-241385
17.65Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
17.65Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
17.65Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
17.65Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
17.65Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
17.65Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
17.65Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
17.65Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
17.65Single7W41PD1762527W41-BB2-PD176252
17.65Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
17.65Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
17.65Single8GNEKW-63568GNE-A2A-KW-6356-Na
17.65Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
17.65Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
17.65Single8WGBVU01550418WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
17.65Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
17.65Single8ZYTNeurotensin peptide 8-138ZYT-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
17.65Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
17.65Single9GE2ML1849GE2-GPR55-ML184-chim(NtGi1-G13)/β1/γ2
17.65Consensusadgrg2_onOrthosteric Ligand7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
17.65Consensusadgrg2_on_gpOrthosteric Ligand7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
17.65Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
17.65Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
17.65Consensusblt_offOrthosteric Ligandblt1_off
17.65Consensusbombesin_offOrthosteric Ligandbb2_off
17.65Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
17.65Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
17.65Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
17.65Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
17.65Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
17.65Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
17.65Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
17.65Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
17.39Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
17.39Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
17.39Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
17.39Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
17.39Single8W8YGamma-MSH8W8Y-MC3-γ-MSH-Ca-Gs/β1/γ2
17.39Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
17.39Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
17.39Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
17.39Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
17.39Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
17.39Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
17.39Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
17.39Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
17.39Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
17.39Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
17.24Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
17.24Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
16.67Single3OE8IT1t3OE8-CXCR4-IT1t
16.67Single4BV0Neurotensin4BV0-NTS1-Neurotensin
16.67Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
16.67Single5TZRMK86665TZR-FFA1-MK8666
16.67Single5V56TC1145V56-SMO-TC114
16.67Single5V57TC1145V57-SMO-TC114
16.67Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
16.67Single5XR8AM8415XR8-CB1-AM841
16.67Single5XRAAM115425XRA-CB1-AM11542
16.67Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
16.67Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
16.67Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
16.67Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
16.67Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
16.67Single7FEECP559407FEE-CB1-CP55940-ZCZ011
16.67Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
16.67Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
16.67Single7PX4PSB-21137PX4-A2A-PSB-2113
16.67Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
16.67Single7T9NDPPC7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
16.67Single7TUYGSK682753A7TUY-GPR183-GSK682753A
16.67Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
16.67Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
16.67Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
16.67Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
16.67Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
16.67Single8A2OTheophylline8A2O-A2A-Theophylline-Na
16.67Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
16.67Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
16.67Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
16.67Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
16.67Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
16.67Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
16.67Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
16.67Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
16.67Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Gi1/β1/γ2
16.67Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
16.67Single8Y73Peptide8Y73-μ-Peptide-MPAM-15-Gi1/β1/γ2
16.67Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single9EGOYVF9EGO-CB1-YVF-Gi1/β1/γ2
16.67Single9I54A1IZV9I54-D1-A1IZV-Gs/β1/γ2
16.67Consensusa2_onOrthosteric Liganda2b_on
16.67Consensusa2_on_gpOrthosteric Liganda2b_on_gp
16.67Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
16.67Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
16.67Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
16.67Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
16.67Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
16.67Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
16.67Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
16.67Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
16.67Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
16.67Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
16.67Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
16.67Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
16.13Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
16.00Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
16.00Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
16.00Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
16.00Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
16.00Single8ZRTET-18ZRT-ETB-ET-1
16.00Single9JFYhNPSF9JFY-NPFF2-hNPSF-Gi1/β1/γ2
16.00Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
16.00Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
16.00Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
16.00Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
15.79Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
15.79Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
15.79Single4PY02MeSATP4PY0-P2Y12-2MeSATP
15.79Single5TZYMK8666; AP85TZY-FFA1-MK8666; AP8
15.79Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
15.79Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
15.79Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
15.79Single6KQICP559406KQI-CB1-CP55940-Org27569
15.79Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
15.79Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
15.79Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
15.79Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
15.79Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
15.79Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
15.79Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
15.79Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
15.79Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
15.79Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
15.79Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.79Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
15.79Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
15.79Single8JJLOlodaterol8JJL-β2-Olodaterol
15.79Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
15.79Single8JWZAB9288JWZ-A2A-AB928-Na
15.79Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
15.79Single8XQJJN2418XQJ-Apelin-JN241
15.79Single8XYIVUF106618XYI-CXCR3-VUF10661
15.79Single9BJKNAM9BJK-μ-Naloxone-NAM
15.79Single9DGIZ85267113509DGI-CB1-Z8526711350
15.79Single9GL2Befiradol9GL2-5-HT1A-Befiradol-Gs/β1/γ2
15.79Single9M4QDoxazosin9M4Q-Alpha1A-Doxazosin
15.79Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
15.79Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
15.79Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
15.79Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
15.79Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
15.79Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
15.79Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
15.79Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
15.79Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
15.79Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
15.79Consensusorexin_onOrthosteric Ligandox2_on
15.79Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
15.79Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
15.38Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
15.38Single6FJ3PTH6FJ3-PTH1-PTH
15.38Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
15.38Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
15.38Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
15.38Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
15.38Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/β1/γ2
15.38Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
15.38Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
15.38Single8J6QCompound 9n8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
15.38Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
15.38Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
15.38Single9JHJC18:0 Ceramide9JHJ-FPR2-ALX-C18:0 Ceramide-Gi1/β1/γ2
15.38Single9KFKRelaxin-39KFK-RXFP4-Relaxin-3-Gi2/β1/γ2
15.15Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
15.15Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
15.00Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
15.00Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
15.00Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
15.00Single6IBLArformoterol6IBL-β1-Arformoterol
15.00Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
15.00Single7EZCUKA7EZC-A2A-UKA
15.00Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.00Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
15.00Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
15.00Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
15.00Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
15.00Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
15.00Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
15.00Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
15.00Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
15.00Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
15.00Single8ZWGJR14a8ZWG-C3aB-JR14a-Gi1/β1/γ2
15.00Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
15.00Single9AS02-bromo-LSD9AS0-5-HT2A-2-bromo-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
15.00Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
15.00Single9M54Neuropeptide VF9M54-NPFF2-Neuropeptide VF-Gi1/β1/γ2
15.00Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
15.00Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
15.00Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
15.00Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
14.81Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
14.81Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
14.81Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
14.81Single8W8XBeta-MSH8W8X-MC3-β-MSH-Ca-Gs/β1/γ2
14.81Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
14.81Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
14.29Single4O9RCyclopamine4O9R-SMO-Cyclopamine
14.29Single4UG2CGS216804UG2-A2A-CGS21680
14.29Single5L7IVismodegib5L7I-SMO-Vismodegib
14.29Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
14.29Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
14.29Single5WF6UK-4320975WF6-A2A-UK-432097
14.29Single5ZTYAM102575ZTY-CB2-AM10257
14.29Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
14.29Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
14.29Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
14.29Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
14.29Single7XN9L-054,5227XN9-SST2-L-054,522
14.29Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
14.29Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
14.29Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
14.29Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
14.29Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
14.29Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
14.29Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/β1/γ2
14.29Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
14.29Single8QJ2pN1628QJ2-MC4-pN162-Gs
14.29Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab
14.29Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
14.29Single8XQJJN2418XQJ-Apelin-JN241
14.29Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
14.29Single8Y72Peptide8Y72-μ-Peptide-BMS-986122-Gi1/β1/γ2
14.29Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
14.29Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
14.29Single8ZYUNeurotensin peptide 8-138ZYU-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
14.29Single9IPVJR14a9IPV-C3aB-JR14a-Gi1/β1/γ2
14.29Single9IPYJR14a9IPY-C3aB-JR14a
14.29Single9JF4PD1683689JF4-BB1-PD168368
14.29Single9V2NMacimorelin9V2N-Ghrelin-Macimorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg4_on
14.29Consensusadgrg_on_gpOrthosteric Ligandadgrg2_on_gp adgrg4_on_gp
14.29Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
14.29Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
14.29Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
14.29Consensusendothelin_onOrthosteric Ligandetb_on eta_on
14.29Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
14.29Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
14.29Consensuskisspeptin_onOrthosteric Ligandkiss1_on
14.29Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
14.29Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
13.79Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
13.64Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
13.64Single4IARErgotamine4IAR-5-HT1B-Ergotamine
13.64Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
13.64Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
13.64Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
13.64Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
13.64Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
13.64Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
13.64Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
13.64Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
13.64Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
13.64Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
13.64Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.64Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
13.64Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
13.64Single8IEBA1LYA8IEB-GPR156-A1LYA
13.64Single8IEIA1LYA8IEI-GPR156-A1LYA
13.64Single8IEIA1LYA8IEI-GPR156-A1LYA
13.64Single8IEPA1LYA8IEP-GPR156-A1LYA
13.64Single8IEPA1LYA8IEP-GPR156-A1LYA
13.64Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
13.64Single8PKMBefiradol8PKM-5-HT1A-Befiradol-Gi1/β1/γ1
13.64Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
13.64Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
13.64Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
13.64Single9BUECagrilintide9BUE-CT-Cagrilintide-Gs/β1/γ2
13.64Single9M4TSilodosin9M4T-Alpha1A-Silodosin
13.64Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
13.64Consensuslpl_onOrthosteric Ligands1p_on lpa_on
13.64Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
13.33Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
13.33Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
13.33Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
13.33Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
13.33Single4QINSAG1.54QIN-SMO-SAG1.5
13.33Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
13.33Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
13.33Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
13.33Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
13.33Single6ME2Ramelteon6ME2-MT1-Ramelteon
13.33Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
13.33Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
13.33Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
13.33Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
13.33Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
13.33Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
13.33Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
13.33Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
13.33Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
13.33Single7XRRLemborexant7XRR-OX2-Lemborexant
13.33Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
13.33Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
13.33Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.33Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
13.33Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
13.33Single8U4PAMD31008U4P-CXCR4-AMD3100-Gi1/β1/γ2
13.33Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
13.33Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
13.33Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
13.33Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
13.33Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
13.33Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
13.33Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
13.33Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
13.33Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
13.33Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
13.33Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
13.04Single3QAKUK-4320973QAK-A2A-UK-432097
13.04Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
13.04Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
13.04Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
13.04Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
13.04Single8IEBA1LYA8IEB-GPR156-A1LYA
13.04Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
13.04Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
13.04Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
13.04Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
13.04Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
13.04Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
12.82Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
12.50Single2YDOAdenosine2YDO-A2A-Adenosine
12.50Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
12.50Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
12.50Single5IU7Q274563465IU7-A2A-Q27456346-Na
12.50Single5IUBQ274563445IUB-A2A-Q27456344-Na
12.50Single5JTBZM-2413855JTB-A2A-ZM-241385
12.50Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
12.50Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
12.50Single5WF5UK-4320975WF5-A2A-UK-432097
12.50Single6AQFZM-2413856AQF-A2A-ZM-241385
12.50Single6IQLL7458706IQL-D4-L745870
12.50Single6KUXRS-799486KUX-α2a-RS-79948
12.50Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
12.50Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
12.50Single6V9SGTPL114036V9S-OX1-GTPL11403
12.50Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
12.50Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
12.50Single6ZG9GSK10347026ZG9-M1-GSK1034702
12.50Single6ZINSR486926ZIN-NTS1-SR48692
12.50Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
12.50Single7T32ZM-2413857T32-A2A-ZM-241385
12.50Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
12.50Single7UL3Famotidine7UL3-H2-Famotidine
12.50Single7UTZDPPC7UTZ-TSH-TR1402-DPPC-Gs/β1/γ2
12.50Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
12.50Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
12.50Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
12.50Single8K9LDamgo8K9L-μ-Damgo-BMS-986122-Gi3/β1/γ1
12.50Single8RLNLUF58348RLN-A2A-LUF5834
12.50Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
12.50Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
12.50Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
12.50Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
12.50Single8Y6YGLPG09748Y6Y-FFA2-GLPG0974
12.50Single8YRGFospropofol8YRG-MRGPRX4-Fospropofol-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single8ZPNAMD31008ZPN-CXCR4-AMD3100
12.50Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
12.50Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
12.50Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
12.50Single9M1OMorphine-Modulating Neuropeptide B9M1O-NPFF2-Morphine-Modulating Neuropeptide B-Gi1/β1/γ2
12.50Single9U4WGonadoliberin-19U4W-GnRH1-Gonadoliberin-1-chim(NtGi1L-Gs-CtGq)/β1/γ2
12.50Consensusa2_offOrthosteric Liganda2a_off
12.50Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
12.50Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
12.50Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
12.50Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
12.50Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
12.50Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
12.12Consensuspth_onOrthosteric Ligandpth1_on pth2_on
12.00Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
12.00Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
12.00Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
12.00Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
12.00Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
12.00Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
12.00Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
12.00Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
12.00Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
12.00Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
12.00Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
12.00Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
12.00Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
11.76Single2Y02Carmoterol2Y02-β1-Carmoterol
11.76Single2Y04Salbutamol2Y04-β1-Salbutamol
11.76Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
11.76Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
11.76Single4QKX35V4QKX-β2-35V
11.76Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
11.76Single5DHGC-355DHG-NOP-C-35
11.76Single5IU8Q274563475IU8-A2A-Q27456347-Na
11.76Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
11.76Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
11.76Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
11.76Single5TGZAM65385TGZ-CB1-AM6538
11.76Single5UENDU1725UEN-A1-DU172
11.76Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
11.76Single6DRXLisuride6DRX-5-HT2B-Lisuride
11.76Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
11.76Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
11.76Single6TOTLemborexant6TOT-OX1-Lemborexant
11.76Single6XBM5LWE6XBM-SMO-5LWE-Gi1/β1/γ2
11.76Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
11.76Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
11.76Single7F83PF-051904577F83-Ghrelin-PF-05190457
11.76Single7PYRPSB-21157PYR-A2A-PSB-2115
11.76Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
11.76Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
11.76Single7UL4Alvimopan7UL4-μ-Alvimopan
11.76Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
11.76Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
11.76Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
11.76Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
11.76Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
11.76Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
11.76Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
11.76Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
11.76Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
11.76Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
11.76Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
11.76Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
11.76Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
11.76Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
11.76Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
11.76Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
11.76Single9CHXS-Carazolol9CHX-β2-S-Carazolol
11.76Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
11.76Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
11.76Single9JGKBalovaptan9JGK-5-HT2B-Balovaptan
11.76Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
11.76Consensusa3_onOrthosteric Liganda3a_on
11.76Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
11.76Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
11.76Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
11.76Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
11.54Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
11.54Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
11.54Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
11.54Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
11.54Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
11.54Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
11.54Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
11.54Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
11.54Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
11.54Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
11.54Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
11.54Consensuspac_onOrthosteric Ligandpac1_on
11.43Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
11.11Single2Y00Dobutamine2Y00-β1-Dobutamine
11.11Single2Y03Isoprenaline2Y03-β1-Isoprenaline
11.11Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
11.11Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
11.11Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
11.11Single5N2RPSB-365N2R-A2A-PSB-36-Na
11.11Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
11.11Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
11.11Single5WIUNemonapride5WIU-D4-Nemonapride
11.11Single5WIVNemonapride5WIV-D4-Nemonapride-Na
11.11Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
11.11Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
11.11Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
11.11Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
11.11Single6LUQHaloperidol6LUQ-D2-Haloperidol
11.11Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
11.11Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
11.11Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
11.11Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
11.11Single6Z4SSR486926Z4S-NTS1-SR48692
11.11Single7C4SS1P7C4S-S1P3-S1P
11.11Single7C61Ergotamine7C61-5-HT1B-Ergotamine
11.11Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
11.11Single7LD3Adenosine7LD3-A1-Adenosine-MIPS521-Gi2/β1/γ2
11.11Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
11.11Single7SINNPS-21437SIN-CaS-NPS-2143
11.11Single7SINNPS-21437SIN-CaS-NPS-2143
11.11Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
11.11Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
11.11Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
11.11Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
11.11Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
11.11Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
11.11Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
11.11Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
11.11Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
11.11Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
11.11Single8JXSPF-61428JXS-D1-PF-6142
11.11Single8QOTNanobody-E8QOT-μ-Nanobody-E
11.11Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
11.11Single8XYKVUF106618XYK-CXCR3-VUF10661-Go/β1/γ2
11.11Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
11.11Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
11.11Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
11.11Single9EE8Adenosine9EE8-A2A-Adenosine-Gs/β1/γ2
11.11Single9F34FOB02-04A9F34-D3-FOB02-04A-Go/β1/γ2
11.11Single9I52A1IZU9I52-D1-A1IZU-Gs/β1/γ2
11.11Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
11.11Consensusa3_on_gpOrthosteric Liganda3a_on_gp
11.11Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
11.11Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
11.11Consensusadenosine_offOrthosteric Liganda1_off a2_off
11.11Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
11.11Consensusclass-b2_onOrthosteric Ligandadgrg_on adgrf_on adgrl_on adgre_on adgrd_on
11.11Consensusclass-b2_on_gpOrthosteric Ligandadgrg_on_gp adgrf_on_gp adgrl_on_gp adgre_on_gp adgrd_on_gp
11.11Consensuscrf2_on_gpOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
11.11Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
11.11Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
11.11Consensusep_offOrthosteric Ligandep4_off
11.11Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
11.11Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
11.11Consensuspac_on_gpOrthosteric Ligandpac1_on_gp
11.11Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
11.11Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
11.11Consensussecretin_onOrthosteric Ligand7D3S-Secretin-Secretin-Gs/β1/γ2
11.11Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
11.11Consensustrace-amine_onOrthosteric Ligandta1_on
10.81Consensuspth_on_gpOrthosteric Ligandpth1_on_gp pth2_on_gp
10.71Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
10.71Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
10.71Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
10.71Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
10.71Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
10.71Single8W8WAlpha-MSH8W8W-MC3-α-MSH-Ca-Gs/β1/γ2
10.71Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
10.71Consensusglp2_on_gpOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
10.71Consensusglp_onOrthosteric Ligandglp1_on glp2_on
10.71Consensusglp_on_gpOrthosteric Ligandglp1_on_gp glp2_on_gp
10.71Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
10.71Consensussecretin_on_gpOrthosteric Ligand7D3S-Secretin-Secretin-Gs/β1/γ2
10.53Single2YDVNECA2YDV-A2A-NECA
10.53Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
10.53Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
10.53Single4UHRCGS216804UHR-A2A-CGS21680
10.53Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
10.53Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
10.53Single5G53NECA5G53-A2A-NECA-Gs
10.53Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
10.53Single6H7JIsoprenaline6H7J-β1-Isoprenaline
10.53Single6J20Aprepitant6J20-NK1-Aprepitant
10.53Single6J21Aprepitant6J21-NK1-Aprepitant
10.53Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
10.53Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
10.53Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
10.53Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
10.53Single6WGTLSD6WGT-5-HT2A-LSD
10.53Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
10.53Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
10.53Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
10.53Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
10.53Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
10.53Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
10.53Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
10.53Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
10.53Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
10.53Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
10.53Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
10.53Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
10.53Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
10.53Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
10.53Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
10.53Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
10.53Single8XVLZibotentan8XVL-ETA-Zibotentan
10.53Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
10.53Single8ZWFJR14a8ZWF-C3aB-JR14a
10.53Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
10.53Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
10.53Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
10.53Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
10.53Single9JMCDS-3801b9JMC-Motilin-DS-3801b-chim(Gs-CtGq)/β1/γ2
10.53Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
10.53Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
10.53Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
10.53Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
10.53Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
10.53Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
10.53Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
10.53Consensuslpa_onOrthosteric Ligandlpa1_on
10.53Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
10.53Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
10.53Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
10.53Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
10.34Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
10.34Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
10.34Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
10.34Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
10.34Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
10.34Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
10.34Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
10.34Single9BYOExendin-39BYO-GLP-1-Exendin-3-Gs/β1/γ2
10.34Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
10.34Consensusvpac2_on_gpOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
10.00Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
10.00Single4AMIBucindolol4AMI-β1-Bucindolol
10.00Single4LDEBI1671074LDE-β2-BI167107
10.00Single4N4WSANT-14N4W-SMO-SANT-1
10.00Single4RWADIPP-NH24RWA-δ-DIPP-NH2
10.00Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
10.00Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
10.00Single5X33BIIL2605X33-BLT1-BIIL260
10.00Single6MXTSalmeterol6MXT-β2-Salmeterol
10.00Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
10.00Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
10.00Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
10.00Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
10.00Single6ZG4HTL00099366ZG4-M1-HTL0009936
10.00Single7DFPSpiperone7DFP-D2-Spiperone
10.00Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
10.00Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
10.00Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
10.00Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
10.00Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
10.00Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
10.00Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
10.00Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
10.00Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
10.00Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
10.00Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
10.00Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
10.00Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
10.00Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
10.00Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
10.00Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.00Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
10.00Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
10.00Single8Y6WTUG-13758Y6W-FFA2-TUG-1375-4-CMTB-Gi1/β1/γ2
10.00Single9EBIPiclidenoson9EBI-A3A-Piclidenoson-chim(NtGi1L-Gs-CtGi1)/β1/γ2
10.00Single9GGGI-BOP9GGG-TXA2-I-BOP-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.00Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
10.00Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
10.00Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
10.00Consensusalpha1_offOrthosteric Ligandalpha1a_off
10.00Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
10.00Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
10.00Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
10.00Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
10.00Consensusclass-a_class-b1_cons_onOrthosteric Ligandclass-a_on class-b1_on
10.00Consensuscrf1_onOrthosteric Ligand6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF1-Corticoliberin-Gs/β1/γ2
10.00Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
10.00Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
10.00Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
10.00Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
10.00Consensusgip_onOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
10.00Consensusgip_on_gpOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
10.00Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
10.00Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
10.00Consensuslpa_offOrthosteric Ligandlpa1_off
10.00Consensuslpl_offOrthosteric Ligands1p_off lpa_off
10.00Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
10.00Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
10.00Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
10.00Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
10.00Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
10.00Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
10.00Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
10.00Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
10.00Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
9.68Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
9.68Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
9.52Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
9.52Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
9.52Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
9.52Single6H7LDobutamine6H7L-β1-Dobutamine
9.52Single6K1QIRL25006K1Q-ETB-IRL2500
9.52Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
9.52Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
9.52Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
9.52Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
9.52Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
9.52Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
9.52Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
9.52Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
9.52Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
9.52Single7UM4AS26747237UM4-5-HT5A-AS2674723
9.52Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
9.52Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.52Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
9.52Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
9.52Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
9.52Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
9.52Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
9.52Single8S2TIsoprenaline8S2T-β1-Isoprenaline-chim(NtGi1-Gs)/β1/γ2
9.52Single8T3OTUG-8918T3O-FFA4-TUG-891-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.52Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
9.52Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
9.52Single9C0KExendin-49C0K-GLP-1-Exendin-4-Gs/β1/γ2
9.52Single9GG5U466199GG5-TXA2-U46619-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.52Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
9.52Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
9.52Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
9.52Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
9.52Consensusendothelin_offOrthosteric Ligandetb_off
9.52Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
9.38Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
9.38Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
9.38Consensuscrf1_on_gpOrthosteric Ligand6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF1-Corticoliberin-Gs/β1/γ2
9.38Consensuscrf_on_gpOrthosteric Ligandcrf2_on_gp crf1_on_gp
9.09Single3NY9ICI118-5513NY9-β2-ICI118-551
9.09Single5MZPCaffeine5MZP-A2A-Caffeine-Na
9.09Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
9.09Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
9.09Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
9.09Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
9.09Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
9.09Single8GEJConstrained Epinephrine8GEJ-β2-Constrained Epinephrine-Gs/β1/γ2
9.09Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
9.09Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
9.09Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
9.09Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
9.09Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
9.09Single9MD1Buspirone9MD1-5-HT1A-Buspirone-Gz/β1/γ2
9.09Single9NS9TUG-13759NS9-FFA2-TUG-1375-Compound 187-Gi1/β1/γ2
9.09Consensusclass-a_class-b1_cons_on_gpOrthosteric Ligandclass-a_on_gp class-b1_on_gp
9.09Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
8.82Consensusgluc_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
8.82Consensusglucagon_on_gpOrthosteric Ligandglp_on_gp gluc_on_gp secretin_on_gp gip_on_gp
8.70Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
8.70Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
8.70Single7QA8Peptide7QA8-STE2-Peptide
8.70Single7QA8Peptide7QA8-STE2-Peptide
8.70Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
8.70Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
8.70Single8KIGSHU91198KIG-MC3-SHU9119-Ca
8.70Single8WKYPG-9348WKY-MC4-PG-934
8.70Single8YWFRetatrutide8YWF-GLP-1-Retatrutide-chim(NtGi1-Gs)/β1/γ2
8.70Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
8.70Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
8.57Consensusgluc_on_gpOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
8.33Single6HLOAprepitant6HLO-NK1-Aprepitant
8.33Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
8.33Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
8.33Single7WC4Serotonin7WC4-5-HT2A-Serotonin
8.33Single7XKDBeta-Hydroxyandrosterone7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
8.33Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
8.33Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
8.33Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
8.33Single8X9S5alpha-DHT8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
8.33Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
8.33Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
8.33Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
8.33Consensuspth2_on_gpOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
8.00Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
8.00Single6W25SHU91196W25-MC4-SHU9119-Ca
8.00Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
8.00Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
8.00Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
8.00Single9B5YLong-Acting PTH9B5Y-PTH1-Long-Acting PTH-chim(NtGi1-Gq)/β1/γ2
8.00Consensusclass-b1_class-b2_cons_onOrthosteric Ligandclass-b1_on class-b2_on
8.00Consensusclass-b1_class-b2_cons_on_gpOrthosteric Ligandclass-b1_on_gp class-b2_on_gp
8.00Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
8.00Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
7.69Single3RFMCaffeine3RFM-A2A-Caffeine
7.69Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
7.69Single6TQ9SB-4081246TQ9-OX1-SB-408124
7.69Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
7.69Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
7.69Single6XBM5LWE6XBM-SMO-5LWE-Gi1/β1/γ2
7.69Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
7.69Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
7.69Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
7.69Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
7.69Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
7.69Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
7.69Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
7.69Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ2
7.69Single9BLCCagrilintide backbone (non-acylated)9BLC-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
7.69Single9BUDCagrilintide9BUD-CT-Cagrilintide-Gs/β1/γ2
7.69Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
7.69Single9EBOGLP-1 (ACPC18)9EBO-GLP-1-GLP-1 (ACPC18)-Gs/β1/γ2
7.69Single9EE9Adenosine9EE9-A2A-Adenosine-Gs/β1/γ2
7.69Single9IVMLSN33188399IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
7.69Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
7.69Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
7.69Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
7.69Consensussensory_onOrthosteric Ligandopsins_on
7.69Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
7.69Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
7.69Consensusvasop-oxy_onOrthosteric Ligandv2_on
7.69Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
7.41Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
7.41Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
7.41Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
7.41Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
7.41Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
7.41Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
7.41Consensuscalcitonin_onOrthosteric Ligandctlike_on
7.41Consensusvpac1_onOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
7.41Consensusvpac_onOrthosteric Ligandvpac1_on vpac2_on
7.14Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
7.14Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
7.14Single3UZAGTPL92363UZA-A2A-GTPL9236
7.14Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
7.14Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
7.14Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
7.14Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
7.14Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
7.14Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
7.14Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
7.14Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
7.14Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
7.14Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
7.14Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
7.14Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
7.14Single7WC5Psilocin7WC5-5-HT2A-Psilocin
7.14Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
7.14Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
7.14Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
7.14Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
7.14Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
7.14Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
7.14Single8JPSCCL78JPS-ACKR1-CCL7
7.14Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
7.14Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
7.14Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
7.14Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
7.14Single9BLBCagrilintide backbone (non-acylated)9BLB-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
7.14Single9BLWCagrilintide backbone (non-acylated)9BLW-CT (AMY1)-Cagrilintide backbone (non-acylated)-Gs/β1/γ2; RAMP1
7.14Single9BP3Cagrilintide9BP3-CT (AMY1)-Cagrilintide-Gs/β1/γ2; RAMP1
7.14Single9BUBCagrilintide9BUB-CT-Cagrilintide-Gs/β1/γ2
7.14Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
7.14Consensuscalcitonin_on_gpOrthosteric Ligandctlike_on_gp
7.14Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
7.14Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
7.14Consensusgi_sensoryOrthosteric Ligandgi_opsins
7.14Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
7.14Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
7.14Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
7.14Consensuspac1_onOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
7.14Consensuspac1_on_gpOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
7.14Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
7.14Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
7.14Consensusvpac1_on_gpOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
7.14Consensusvpac_on_gpOrthosteric Ligandvpac1_on_gp vpac2_on_gp
6.90Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
6.90Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
6.90Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
6.90Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
6.90Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
6.90Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
6.90Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
6.90Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
6.90Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
6.90Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
6.90Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
6.90Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
6.90Single9BUCCagrilintide9BUC-CT-Cagrilintide-Gs/β1/γ2
6.90Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
6.67Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
6.67Single3PBLEticlopride3PBL-D3-Eticlopride
6.67Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
6.67Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
6.67Single6HLLCP999946HLL-NK1-CP99994
6.67Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
6.67Single6LI0C176LI0-GPR52-C17
6.67Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
6.67Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
6.67Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
6.67Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
6.67Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
6.67Single6TP4ACT-4622066TP4-OX1-ACT-462206
6.67Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
6.67Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
6.67Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
6.67Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
6.67Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.67Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
6.67Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
6.67Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
6.67Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
6.67Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
6.67Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
6.67Single7XP6Strychnine7XP6-TAS2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
6.67Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
6.67Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
6.67Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
6.67Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
6.67Single8HSCFab0468HSC-GPR20-Fab046-Gi1/β1/γ2
6.67Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
6.67Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
6.67Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
6.67Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
6.67Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
6.67Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.67Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
6.67Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
6.67Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
6.67Single9AS2DMT9AS2-5-HT2A-DMT-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67Single9B9Y7DY9B9Y-CB1-7DY
6.67Single9BTWCagrilintide9BTW-CT (AMY3)-Cagrilintide-Gs/β1/γ2; RAMP3
6.67Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
6.67Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
6.67Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
6.67Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
6.67Consensusctlike_on_gpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
6.67Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
6.67Consensuspth1_onOrthosteric Ligand6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
6.67Consensusvip-pacap_onOrthosteric Ligandvpac_on pac_on
6.67Consensusvip-pacap_on_gpOrthosteric Ligandvpac_on_gp pac_on_gp
6.45Single7RBTTirzepatide7RBT-GIP-Tirzepatide-LSN3556672-chim(NtGi1-Gs)/β1/γ2
6.45Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
6.25Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
6.25Single4S0VSuvorexant4S0V-OX2-Suvorexant
6.25Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
6.25Single5U09Taranabant5U09-CB1-Taranabant
6.25Single5WS3EMPA5WS3-OX2-EMPA
6.25Single6B73MP11046B73-κ-MP1104
6.25Single6DS0Ly2660976DS0-5-HT2B-Ly266097
6.25Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
6.25Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
6.25Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
6.25Single6TODEMPA6TOD-OX1-EMPA-Na
6.25Single6TPJSuvorexant6TPJ-OX2-Suvorexant
6.25Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
6.25Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
6.25Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
6.25Single7F8YDevazepide7F8Y-CCKA-Devazepide
6.25Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
6.25Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
6.25Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
6.25Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
6.25Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.25Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
6.25Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
6.25Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
6.25Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
6.25Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
6.25Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
6.25Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
6.25Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
6.25Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
6.25Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
6.25Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
6.25Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
6.25Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
6.25Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
6.25Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
6.25Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
6.25Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
6.25Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
6.25Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
6.25Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
6.25Single8IWESpermidine8IWE-TA9-Spermidine
6.25Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
6.25Single8T3VDocosa-4,7,10,13,16,19-Hexaenoic acid8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.25Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
6.25Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
6.25Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
6.25Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
6.25Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
6.25Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
6.25Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
6.25Single8Y0HVUF114188Y0H-CXCR3-VUF11418
6.25Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go/β1/γ2
6.25Single9AUCCalcitonin gene-related peptide-19AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
6.25Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
6.25Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
6.25Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
6.25Single9EBHAdenosine9EBH-A3A-Adenosine-Gi1/β1/γ2
6.25Single9EEAAdenosine9EEA-A2A-Adenosine-Gs/β1/γ2
6.25Single9KPESA09KPE-TAS2R16-SA0-Gi1/β1/γ2
6.25Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
6.25Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
6.25Consensusalpha2_offOrthosteric Ligandalpha2c_off
6.25Consensusangiotensin_offOrthosteric Ligandat1_off
6.25Consensusglp1_onOrthosteric Ligand7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
6.25Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
6.25Consensusorexin_offOrthosteric Ligandox2_off ox1_off
6.25Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
6.25Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
6.25Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
6.25Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
6.25Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
6.06Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
6.06Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
6.06Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
6.06Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
6.06Consensusglp1_on_gpOrthosteric Ligand7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
6.06Consensuspth1_on_gpOrthosteric Ligand6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
5.88Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
5.88Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
5.88Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
5.88Single4ZJCSB-6740424ZJC-OX1-SB-674042
5.88Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
5.88Single6A94Zotepine6A94-5-HT2A-Zotepine
5.88Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
5.88Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
5.88Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
5.88Single6PS0S-Carazolol6PS0-β2-S-Carazolol
5.88Single6PS4ICI118-5516PS4-β2-ICI118-551
5.88Single6PS5S-Propranolol6PS5-β2-S-Propranolol
5.88Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
5.88Single6TP3Nemorexant6TP3-OX1-Nemorexant
5.88Single6TPGEMPA6TPG-OX2-EMPA
5.88Single6TPKRetosiban6TPK-OT-Retosiban
5.88Single6TPNHTL66416TPN-OX2-HTL6641
5.88Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
5.88Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
5.88Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
5.88Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
5.88Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
5.88Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
5.88Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
5.88Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
5.88Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.88Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.88Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
5.88Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
5.88Single7VODCariprazine7VOD-5-HT2A-Cariprazine
5.88Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
5.88Single7VV6C48/807VV6-MRGPRX2-C48/80
5.88Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
5.88Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
5.88Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
5.88Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
5.88Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
5.88Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
5.88Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
5.88Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
5.88Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
5.88Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
5.88Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
5.88Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.88Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.88Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.88Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
5.88Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
5.88Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
5.88Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
5.88Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
5.88Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
5.88Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
5.88Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
5.88Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
5.88Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
5.88Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
5.88Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
5.88Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
5.88Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
5.88Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
5.88Single8K2WAMG4878K2W-CXCR3-AMG487
5.88Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.88Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.88Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.88Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.88Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.88Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.88Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
5.88Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
5.88Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
5.88Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
5.88Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
5.88Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.88Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
5.88Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
5.88Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
5.88Single9AS3LSD9AS3-5-HT2A-LSD
5.88Single9AS4LSD9AS4-5-HT2A-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88Single9AS5Mescaline9AS5-5-HT2A-Mescaline
5.88Single9AS6Mescaline9AS6-5-HT2A-Mescaline-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
5.88Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88Single9BA0A1AKN9BA0-CB1-A1AKN
5.88Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88Single9IXXLTD49IXX-CysLT2-LTD4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88Single9JH3CMF-0199JH3-Apelin-CMF-019-Gi1/β1/γ2
5.88Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Gi1/β1/γ2
5.88Single9KPDSA09KPD-TAS2R16-SA0-chim(Gs-CtGt3)/β1/γ2
5.88Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
5.88Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
5.88Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
5.88Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
5.88Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
5.88Consensusglucagon_onOrthosteric Ligandglp_on gluc_on secretin_on gip_on
5.88Consensusopsins_offOrthosteric Ligandrhodopsin_off
5.88Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
5.88Consensussensory_offOrthosteric Ligandopsins_off
5.88Consensusvasop-oxy_offOrthosteric Ligandot_off
5.71Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
5.56Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
5.56Single2Y01Dobutamine2Y01-β1-Dobutamine
5.56Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
5.56Single3NY8ICI118-5513NY8-β2-ICI118-551
5.56Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
5.56Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
5.56Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
5.56Single4GBRS-Carazolol4GBR-β2-S-Carazolol
5.56Single5DHHSB-6121115DHH-NOP-SB-612111
5.56Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
5.56Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
5.56Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
5.56Single6GPSMK08126GPS-CCR2-MK0812
5.56Single6H7MSalbutamol6H7M-β1-Salbutamol
5.56Single6IIVDaltroban6IIV-TXA2-Daltroban
5.56Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
5.56Single6PS1Timolol6PS1-β2-Timolol
5.56Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
5.56Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
5.56Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
5.56Single7BU7BI1671077BU7-β1-BI167107
5.56Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
5.56Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
5.56Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
5.56Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
5.56Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
5.56Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
5.56Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
5.56Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
5.56Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
5.56Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
5.56Single7WC7Lisuride7WC7-5-HT2A-Lisuride
5.56Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
5.56Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
5.56Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
5.56Single7YXAONO-54306087YXA-S1P5-ONO-5430608
5.56Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
5.56Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
5.56Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
5.56Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
5.56Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
5.56Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
5.56Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.56Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.56Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.56Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.56Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.56Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.56Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.56Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.56Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.56Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.56Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
5.56Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
5.56Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
5.56Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
5.56Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
5.56Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
5.56Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
5.56Single8JJOAlprenolol8JJO-β2-Alprenolol
5.56Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
5.56Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
5.56Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
5.56Single8T1WCVN4248T1W-GPR6-CVN424
5.56Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.56Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.56Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.56Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.56Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.56Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.56Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.56Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
5.56Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
5.56Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
5.56Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
5.56Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
5.56Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
5.56Single9AS1DMT9AS1-5-HT2A-DMT
5.56Single9IMATalquetamab9IMA-GPRC5D-Talquetamab
5.56Single9IVGGLP-1 (Truncated)9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
5.56Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
5.56Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
5.56Consensus5ht5_onOrthosteric Ligand5ht5a_on
5.56Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
5.56Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
5.56Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
5.56Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
5.56Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
5.56Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
5.56Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
5.56Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
5.56Consensusblt_onOrthosteric Ligandblt1_on
5.56Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
5.56Consensuscck_offOrthosteric Ligandccka_off
5.56Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
5.56Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
5.56Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
5.56Consensusdopamine_offOrthosteric Ligandd2_off d3_off
5.56Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
5.56Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
5.56Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
5.56Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
5.56Consensusleukotriene_onOrthosteric Ligandblt_on
5.56Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
5.41Consensusclass-b1_onOrthosteric Ligandglucagon_on vip-pacap_on pth_on crf_on calcitonin_on
5.26Single2RH1S-Carazolol2RH1-β2-S-Carazolol
5.26Single2YCWS-Carazolol2YCW-β1-S-Carazolol
5.26Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
5.26Single5D6LS-Carazolol5D6L-β2-S-Carazolol
5.26Single5JQHS-Carazolol5JQH-β2-S-Carazolol
5.26Single5T1ABMS-6815T1A-CCR2-BMS-681-PubChem 12093170
5.26Single5TVNLSD5TVN-5-HT2B-LSD
5.26Single5WQCEMPA5WQC-OX2-EMPA
5.26Single5X7DS-Carazolol5X7D-β2-S-Carazolol-Cmpd-15
5.26Single5XPRBosentan5XPR-ETB-Bosentan
5.26Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
5.26Single6E67BI1671076E67-β2-BI167107-Gs(CT)
5.26Single6GPXMK08126GPX-CCR2-MK0812
5.26Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
5.26Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
5.26Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
5.26Single6PS6Timolol6PS6-β2-Timolol
5.26Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
5.26Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
5.26Single6TP6Filorexant6TP6-OX1-Filorexant
5.26Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
5.26Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
5.26Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
5.26Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
5.26Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
5.26Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
5.26Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
5.26Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
5.26Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.26Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
5.26Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
5.26Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
5.26Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
5.26Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
5.26Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
5.26Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
5.26Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
5.26Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
5.26Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
5.26Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.26Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.26Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.26Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
5.26Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
5.26Single8S4DCMF-0198S4D-Apelin-CMF-019
5.26Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
5.26Single8TF5Oleic acid8TF5-GPR6-Oleic acid
5.26Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.26Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.26Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
5.26Single8ZMFA1L108ZMF-5-HT2C-A1L10
5.26Single8ZVZBW245C8ZVZ-DP1-BW245C-Gs/β1/γ2
5.26Single9ARYSerotonin9ARY-5-HT2A-Serotonin-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26Single9ARZ2-bromo-LSD9ARZ-5-HT2A-2-bromo-LSD
5.26Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
5.26Single9B9ZA1AKO9B9Z-CB1-A1AKO
5.26Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26Single9DYDAsenapine9DYD-5-HT1A-Asenapine-Go/β1/γ2
5.26Single9DYFAsenapine9DYF-5-HT1A-Asenapine-Gi1/β1/γ2
5.26Single9F33FOB02-04A9F33-D3-FOB02-04A-Go/β1/γ2
5.26Single9HAPTolvaptan9HAP-V2-Tolvaptan
5.26Single9K07DSO-5a9K07-BB3-DSO-5a-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.26Single9KPFSA09KPF-TAS2R16-SA0-Gi1/β1/γ2
5.26Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
5.26Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
5.26Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
5.26Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
5.26Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
5.26Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
5.26Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
5.26Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
5.26Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
5.26Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
5.26Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
5.26Consensusamine_offonOrthosteric Ligandamine_off amine_on
5.26Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
5.26Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
5.26Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
5.26Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
5.26Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
5.26Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
5.26Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
5.26Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
5.26Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
5.13Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
5.00Single3P0GBI1671073P0G-β2-BI167107
5.00Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
5.00Single4DJHJDTic4DJH-κ-JDTic
5.00Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
5.00Single5D5AS-Carazolol5D5A-β2-S-Carazolol
5.00Single5D5BS-Carazolol5D5B-β2-S-Carazolol
5.00Single5V54Methiothepin5V54-5-HT1B-Methiothepin
5.00Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
5.00Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
5.00Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
5.00Single6E59L-7607356E59-NK1-L-760735
5.00Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
5.00Single6TQ7SB-3348676TQ7-OX1-SB-334867
5.00Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
5.00Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
5.00Single7R0CAVP7R0C-V2-AVP-Arrestin2
5.00Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
5.00Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
5.00Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
5.00Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
5.00Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
5.00Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
5.00Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
5.00Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
5.00Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
5.00Single8E0GBU728E0G-μ-BU72
5.00Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
5.00Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
5.00Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
5.00Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
5.00Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
5.00Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
5.00Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
5.00Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
5.00Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
5.00Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
5.00Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
5.00Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Gi1/β1/γ1
5.00Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
5.00Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
5.00Single8ZW0PGD28ZW0-DP1-PGD2-Gs/β1/γ2
5.00Single9CLWTUG-13759CLW-FFA2-TUG-1375-4-CMTB-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.00Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
5.00Single9IK9SST analogue9IK9-SST1-SST analogue-Gi1/β1/γ2
5.00Consensus5ht1_offOrthosteric Ligand5ht1b_off
5.00Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
5.00Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
5.00Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
5.00Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
5.00Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
5.00Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
5.00Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
5.00Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
5.00Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
5.00Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
5.00Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
5.00Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
5.00Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
5.00Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
5.00Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
5.00Consensustachykinin_offOrthosteric Ligandnk1_off
4.88Consensusclass-b1_on_gpOrthosteric Ligandglucagon_on_gp vip-pacap_on_gp pth_on_gp crf_on_gp calcitonin_on_gp
4.76Single3D4STimolol3D4S-β2-Timolol
4.76Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
4.76Single6A93Risperidone6A93-5-HT2A-Risperidone
4.76Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
4.76Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
4.76Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
4.76Single6IIURamatroban6IIU-TXA2-Ramatroban
4.76Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
4.76Single7YITNalfurafine7YIT-κ-Nalfurafine
4.76Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
4.76Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
4.76Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
4.76Single8JJ8Formoterol8JJ8-β2-Formoterol
4.76Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
4.76Single8XJNCloprosetnol8XJN-TXA2-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
4.76Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
4.76Single9AU0BW245C9AU0-DP1-BW245C-Gs/β1/γ2
4.76Single9CM3TUG-13759CM3-FFA2-TUG-1375-Compound 187-chim(NtGi1L-Gs-CtGq)/β1/γ2
4.76Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
4.76Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
4.76Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
4.55Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
4.55Single5X93K-87945X93-ETB-K-8794
4.55Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
4.55Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
4.55Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
4.55Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
4.55Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
4.55Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
4.55Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
4.55Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
4.55Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
4.55Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
4.55Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
4.55Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55Single8XJOU466198XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55Single9DYEBuspirone9DYE-5-HT1A-Buspirone-Go/β1/γ2
4.55Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
4.55Single9M1HProstaglandin E29M1H-EP1-Prostaglandin E2-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
4.55Consensusfp-alpha_onOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
4.55Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
4.55Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
4.55Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
4.55Consensustp_onOrthosteric Ligand8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55Consensustp_on_gpOrthosteric Ligand8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
4.35Single7SK9CCX6627SK9-ACKR3-CCX662
4.35Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
4.35Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
4.35Single8X5YAstemizole8X5Y-H1-Astemizole
4.35Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
4.35Single9CM7TUG-13759CM7-FFA2-TUG-1375-AZ-1729-Gi1/β1/γ2
4.35Single9JH6C20:0 Ceramide9JH6-CysLT2-C20:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
4.17Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
4.00Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
4.00Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
3.85Single6PT2KGCHM076PT2-δ-KGCHM07
3.85Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.70Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
3.70Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
3.23Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
3.23Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
3.23Single9BQ3Cagrilintide9BQ3-CT (AMY2)-Cagrilintide-Gs/β1/γ2; RAMP2
3.03Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3

Consensus Members
Id Members
7XXH 7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
Net Summary
Imin 3.26
Number of Linked Nodes 841
Number of Links 998
Number of Hubs 149
Number of Links mediated by Hubs 558
Number of Communities 29
Number of Nodes involved in Communities 217
Number of Links involved in Communities 299
Path Summary
Number Of Nodes in MetaPath 100
Number Of Links MetaPath 99
Number of Shortest Paths 1922167
Length Of Smallest Path 3
Average Path Length 36.3554
Length of Longest Path 68
Minimum Path Strength 1.355
Average Path Strength 6.76552
Maximum Path Strength 27.94
Minimum Path Correlation 0.7
Average Path Correlation 0.985363
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.5
Average % Of Corr. Nodes 40.726
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 50.8583
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following consensuses:
IdComponents
gq_nucleotidegq_p2y



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