Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
11x50 5.14429
22x50 6.43188829
32x51 5.02083628
42x38 6.68917637
52x41 4.745426
62x42 6.3175438
72x43 6.425548
82x65 3.736506
9E1x52 5.983556
103x26 3.81407
113x51 6.97875409
124x50 6.9925409
134x57 6.9375408
14E2.K158 3.0325406
15E2x52 7.11125417
16E2.F168 7.2525616
17E2.F169 7.044516
185x37 7.0875404
195x39 5.84875418
205x46 4.774516
215x47 2.50875469
225x61 4.63625409
235x62 2.6425477
246x37 4.105478
256x48 8.81917619
266x51 5.935617
277x42 6.94929718
287x53 5.8375449
298x54 3.53125408
30Lig 10.3222910
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
11x29 1x32 11.66837.895NoNo033
21x32 2x65 14.114.25NoYes036
31x39 2x65 11.80643.535NoYes076
41x39 2x61 19.04343.645NoNo076
51x39 7x39 30.00254.07NoNo078
67x39 7x42 33.69326.56NoYes088
72x64 2x65 10.95915.16NoYes056
82x60 2x64 12.220714.355NoNo075
92x60 7x42 15.867410.61NoYes078
107x42 Lig 50.03774.565YesYes180
116x48 Lig 83.14715.085YesYes190
126x48 7x45 1006.78YesNo099
137x45 7x49 99.598312.26NoNo099
142x50 7x49 73.43718.08YesNo099
151x50 2x50 58.63047.405YesYes299
161x50 2x51 55.72435.435YesYes298
173x43 7x49 29.90215.66NoNo099
183x43 7x53 29.16779.065NoYes099
192x43 7x53 23.10443.61YesYes489
202x43 7x54 25.42684.335YesNo088
211x53 7x54 23.99574.42NoNo098
221x53 8x54 21.35331.965NoYes098
231x52 8x54 12.63492.435NoYes088
242x41 2x51 45.7574.63YesYes268
251x60 2x50 13.708310.855NoYes079
261x60 2x49 10.95284.04NoNo078
272x43 8x47 12.35259.05YesNo089
282x39 8x47 11.4116.275NoNo089
292x37 2x39 10.63274.18NoNo078
302x41 4x42 47.94754.835YesNo067
312x38 4x42 47.32613.76YesNo077
322x38 I2x53 47.79064.63YesNo378
332x61 2x62 17.83834.235NoNo065
342x62 E1x52 12.09527.945NoYes556
356x51 6x55 23.38693.745YesNo177
366x55 E2.F169 18.34047.135NoYes176
37E2.F169 E2x51 24.49163.5YesNo064
38E2.K158 E2x51 14.02842.025YesNo064
396x51 Lig 17.2423.49YesYes170
403x33 Lig 49.981225.405NoYes080
413x33 E2x52 33.47985.56NoYes087
42E2.F169 E2x52 10.24987.945YesYes167
433x33 4x57 21.522712.795NoYes088
444x57 4x59 15.15191.7YesNo085
454x54 4x59 12.42784.52NoNo055
466x44 6x48 13.77739.02NoYes199
473x53 I2x53 47.62748.9NoNo088
483x53 3x54 46.40353.23NoNo088
493x54 5x61 45.14199.215NoYes089
505x61 6x37 22.5272.85YesYes098
515x58 6x37 10.97167.555NoYes098
523x51 5x61 20.27373.63YesYes099
53E2.F168 E2x52 20.386610.835YesYes167
545x39 E2.F168 14.68113.77YesYes186
555x38 5x39 10.36284.23NoYes148
565x51 6x44 12.54713.275NoNo069
575x47 5x51 11.02183.93YesNo096
586x48 7x41 12.634917.52YesNo198
596x51 7x41 12.08267.89YesNo178
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
2x563x326.6251NoNo8821
2x567x426.1751NoYes8821
2x577x426.460NoYes8821
2x607x4210.610NoYes7821
3x327x427.261NoYes8811
3x32Lig9.2151NoYes8010
3x334x5712.7950NoYes8812
3x33E2x525.560NoYes8712
3x33Lig25.4050NoYes8010
3x36Lig7.80NoYes8010
3x375x464.230NoYes8621
3x406x445.241NoNo8922
3x406x487.971NoYes8921
5x466x486.541YesYes6911
5x46Lig9.341YesYes6010
6x446x489.021NoYes9921
6x487x4117.521YesNo9811
6x487x456.781YesNo9912
6x48Lig5.0851YesYes9010
6x516x553.7451YesNo7712
6x517x349.931YesNo7512
6x517x387.221YesNo7611
6x517x417.891YesNo7811
6x51Lig3.491YesYes7010
7x387x427.0151NoYes6811
7x38Lig11.8151NoYes6010
7x397x426.560NoYes8821
7x41Lig16.1851NoYes8010
7x42Lig4.5651YesYes8010
6x517x373.3351YesNo7512
5x455x463.0450NoYes4621
5x425x460.7150NoYes5621

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Single8HOCImetit8HOC-H4-Imetit-Gi1/&β;1/&γ;2
100.00Consensusgi_histamineOrthosteric Ligand8HN8-H4-Histamine-Gi1/&β;1/&γ;2 8HOC-H4-Imetit-Gi1/&β;1/&γ;2
100.00Consensusgs_histamineOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
88.89Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
88.89Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
88.89Single8HN8Histamine8HN8-H4-Histamine-Gi1/&β;1/&γ;2
81.82Consensushistamine_onOrthosteric Ligandh1_on h4_on
80.00Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
80.00Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
80.00Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
72.73Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
72.73Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2
72.73Consensus5ht2a_onOrthosteric Ligand7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
70.00Single8ITFDMCHA8ITF-TAAR9-DMCHA-chim(NtGi1-Gs)/&β;1/&γ;2
70.00Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/&β;1/&γ;2
69.23Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/&β;1/&γ;2
66.67Single4U16N-Methyl Scopolamine4U16-M3-N-Methyl Scopolamine
66.67Single5YC8N-Methyl Scopolamine5YC8-M2-N-Methyl Scopolamine
66.67Single5ZK8N-Methyl Scopolamine5ZK8-M2-N-Methyl Scopolamine
66.67Single5ZKCN-Methyl Scopolamine5ZKC-M2-N-Methyl Scopolamine
66.67Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
66.67Single8WC5Tetramethylammonium ion8WC5-TA1-Tetramethylammonium ion-chim(NtGi1-Gs)/&β;1/&γ;2
66.67Consensusgo_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
66.67Consensusm2_on_alloOrthosteric Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
66.67Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
63.64Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
63.64Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2
63.64Single8IW4Spermidine8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2
63.64Single8IWESpermidine8IWE-TAAR9-Spermidine
63.64Consensusalpha1_onOrthosteric Ligandalpha1a_on
63.64Consensusalpha1a_onOrthosteric Ligand7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
61.54Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
61.54Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
61.54Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
61.54Consensusgs_muscarinicOrthosteric Ligand8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
61.54Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
61.54Consensusm2_offOrthosteric Ligand5ZKB-M2-AF-DX 384 5ZKC-M2-N-Methyl Scopolamine 5ZK3-M2-Quinuclidinyl benzilate hydrobromide
61.54Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
60.00Single8IW72-Phenylethylamine8IW7-TAAR9-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
60.00Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/&β;1/&γ;2
60.00Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
58.33Single2YDOAdenosine2YDO-A2A-Adenosine
58.33Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
58.33Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
58.33Single7CMVPD1289077CMV-D3-PD128907-Gi1/&β;1/&γ;2
58.33Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2
58.33Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
58.33Single8JLNT1AM8JLN-TA1-T1AM-Gs/&β;1/&γ;2
58.33Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
58.33Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
58.33Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/&β;1/&γ;2
58.33Consensusalpha2b_onOrthosteric Ligand6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
58.33Consensusm1_off_alloOrthosteric Ligand6WJC-M1-Atropine-Muscarinic toxin 7
57.14Single2YDVNECA2YDV-A2A-NECA
57.14Single4U15Tiotropium4U15-M3-Tiotropium
57.14Single4UHRCGS216804UHR-A2A-CGS21680
57.14Single5G53NECA5G53-A2A-NECA-Gs
57.14Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
57.14Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
57.14Single6OL9Tiotropium6OL9-M5-Tiotropium
57.14Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
57.14Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
57.14Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
57.14Single8G056-OAU8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
57.14Single8JXVClozapine8JXV-H4-Clozapine-Gi1/&β;1/&γ;2
57.14Single8JXWVUF68848JXW-H4-VUF6884-Gi1/&β;1/&γ;2
57.14Consensusgi_amineOrthosteric Ligandgi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
57.14Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
57.14Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
54.55Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2
54.55Single8GEIEpinephrine8GEI-β2-Epinephrine-Gs/&β;1/&γ;2
54.55Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
54.55Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
53.85Single3NY8ICI 118-5513NY8-β2-ICI 118-551
53.85Single3NYA(S)-Alprenolol3NYA-β2-(S)-Alprenolol
53.85Single4DAJTiotropium4DAJ-M3-Tiotropium
53.85Single4EJ4Naltrindole4EJ4-δ-Naltrindole
53.85Single4GBR(S)-Carazolol4GBR-β2-(S)-Carazolol
53.85Single4MQSIperoxo4MQS-M2-Iperoxo
53.85Single4U14Tiotropium4U14-M3-Tiotropium
53.85Single5DSGTiotropium5DSG-M4-Tiotropium
53.85Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
53.85Single6PS0(S)-Carazolol6PS0-β2-(S)-Carazolol
53.85Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
53.85Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
53.85Single8J18(3R)-3-hydroxydodecanoic acid8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
53.85Single8JJOAlprenolol8JJO-β2-Alprenolol
53.85Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2
53.85Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
53.85Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
53.85Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
53.85Consensusalpha2_onOrthosteric Ligandalpha2a_on alpha2b_on
53.85Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
53.85Consensusamine_onOrthosteric Ligandadrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on
53.85Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
53.85Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
53.85Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
53.85Consensusm4_on_alloOrthosteric Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
53.85Consensustar_onOrthosteric Ligandta1_on
53.33Single5CXVTiotropium5CXV-M1-Tiotropium
53.33Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
53.33Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
53.33Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
53.33Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
50.00Single2RH1(S)-Carazolol2RH1-β2-(S)-Carazolol
50.00Single2YCW(S)-Carazolol2YCW-β1-(S)-Carazolol
50.00Single5D6L(S)-Carazolol5D6L-β2-(S)-Carazolol
50.00Single5X7D(S)-Carazolol5X7D-β2-(S)-Carazolol-PubChem 129318963
50.00Single5ZK3Quinuclidinyl benzilate hydrobromide5ZK3-M2-Quinuclidinyl benzilate hydrobromide
50.00Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
50.00Single6PS6Timolol6PS6-β2-Timolol
50.00Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2
50.00Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
50.00Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
50.00Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2
50.00Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
50.00Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2
50.00Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
50.00Single8E9YPubChem 4466038E9Y-M3-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
50.00Single8EA0Iperoxo8EA0-M3-Iperoxo
50.00Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
50.00Single8GECEpinephrine8GEC-β2-Epinephrine-Gs/&β;1/&γ;2
50.00Single8GEFEpinephrine8GEF-β2-Epinephrine-Gs/&β;1/&γ;2
50.00Single8GGAEpinephrine8GGA-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
50.00Single8GGVEpinephrine8GGV-β2-Epinephrine
50.00Single8GGWEpinephrine8GGW-β2-Epinephrine
50.00Single8GGXEpinephrine8GGX-β2-Epinephrine
50.00Single8GH0Epinephrine8GH0-β2-Epinephrine
50.00Single8IWM2-Phenylethylamine8IWM-TAAR9-2-Phenylethylamine
50.00Single8J19PubChem 1270454228J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
50.00Single8UO0Epinephrine8UO0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
50.00Single8UO3Epinephrine8UO3-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
50.00Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
50.00Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
50.00Consensus5ht2_onOrthosteric Ligand5ht2a_on 5ht2c_on
50.00Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
50.00Consensusa1_on_alloOrthosteric Ligand7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
50.00Consensusalpha2a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
50.00Consensusamine_offOrthosteric Ligandadrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
50.00Consensusbeta2_offOrthosteric Ligand6PS2-β2-(S)-Alprenolol 6PS3-β2-(S)-Carvedilol 6PS5-β2-(S)-Propranolol 6PS6-β2-Timolol 2RH1-β2-(S)-Carazolol 6PS4-β2-ICI 118-551 3NY9-β2-PubChem 913103
50.00Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
50.00Consensusgi_nucleotideOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
50.00Consensusgo_amineOrthosteric Ligandgo_adrenergic go_muscarinic go_5ht
50.00Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
47.06Single4UG2CGS216804UG2-A2A-CGS21680
47.06Single7SK9CCX6627SK9-ACKR3-CCX662
46.67Single3UONQuinuclidinyl benzilate hydrobromide3UON-M2-Quinuclidinyl benzilate hydrobromide
46.67Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
46.67Single5D5A(S)-Carazolol5D5A-β2-(S)-Carazolol
46.67Single5D5B(S)-Carazolol5D5B-β2-(S)-Carazolol
46.67Single6TQ7SB-3348676TQ7-OX1-SB-334867
46.67Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
46.67Single7W6PW967W6P-α2a-W96-Go/&β;1/&γ;2
46.67Single7W7EW587W7E-α2a-W58-Go/&β;1/&γ;2
46.67Single8DZPmomSalB8DZP-κ-momSalB-Gi1/&β;1/&γ;2
46.67Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/&β;1/&γ;2
46.67Consensus5ht_offOrthosteric Ligand5ht2_off 5ht5_off 5ht1_off
46.67Consensusangiotensin_offOrthosteric Ligandat1_off at2_off
46.67Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCZ-β1-Iodocyanopindolol
46.67Consensusdopamine_offOrthosteric Ligandd3_off d2_off d4_off
46.67Consensusgi_muscarinicOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
46.67Consensusgo_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
46.67Consensush1_offOrthosteric Ligand3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole 8X63-H1-Mepyramine 8X64-H1-Desloratadine
46.67Consensushistamine_offOrthosteric Ligandh1_off
46.67Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl Scopolamine 5ZHP-M3-PubChem 134828589
46.15Single4DKLBeta-funaltrexamine4DKL-μ-Beta-funaltrexamine
46.15Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
46.15Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
46.15Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
46.15Single6PS4ICI 118-5516PS4-β2-ICI 118-551
46.15Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
46.15Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
46.15Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
46.15Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
46.15Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
46.15Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
46.15Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
46.15Single8GE1Epinephrine8GE1-β2-Epinephrine-Gs/&β;1/&γ;2
46.15Single8GE4Epinephrine8GE4-β2-Epinephrine-Gs/&β;1/&γ;2
46.15Single8GE6Epinephrine8GE6-β2-Epinephrine-Gs/&β;1/&γ;2
46.15Single8GE7Epinephrine8GE7-β2-Epinephrine-Gs/&β;1/&γ;2
46.15Single8GE8Epinephrine8GE8-β2-Epinephrine-Gs/&β;1/&γ;2
46.15Single8GE9Epinephrine8GE9-β2-Epinephrine-Gs/&β;1/&γ;2
46.15Single8GEGEpinephrine8GEG-β2-Epinephrine-Gs/&β;1/&γ;2
46.15Single8GFVEpinephrine8GFV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
46.15Single8GG4Epinephrine8GG4-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
46.15Single8GGIEpinephrine8GGI-β2-Epinephrine
46.15Single8GGQEpinephrine8GGQ-β2-Epinephrine
46.15Single8GGTEpinephrine8GGT-β2-Epinephrine
46.15Single8UHBRO52563908UHB-TA1-RO5256390-Gs/&β;1/&γ;2
46.15Single8UNQEpinephrine8UNQ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
46.15Single8UNZEpinephrine8UNZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
46.15Single8UO2Epinephrine8UO2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
46.15Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
46.15Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
46.15Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6WH4-5-HT2A-Methiothepin 7VOE-5-HT2A-Aripiprazole 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 6A93-5-HT2A-Risperidone
46.15Consensusd3_onOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
46.15Consensusdop_off_alloOrthosteric Ligand4N6H-δ-Naltrindole-Na
46.15Consensusgs_tarOrthosteric Ligand8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
45.45Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
45.45Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
45.45Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/&β;1/&γ;2
45.45Single8GGREpinephrine8GGR-β2-Epinephrine
45.45Single8GGZEpinephrine8GGZ-β2-Epinephrine
45.45Single8POKHistamine8POK-H2-Histamine-Gs/&β;1/&γ;2
45.45Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
43.75Single3D4STimolol Maleate3D4S-β2-Timolol Maleate
43.75Single4AMIBucindolol4AMI-β1-Bucindolol
43.75Single6A93Risperidone6A93-5-HT2A-Risperidone
43.75Single6CM4Risperidone6CM4-D2-Risperidone
43.75Single6H7N(S)-Xamoterol6H7N-β1-(S)-Xamoterol
43.75Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
43.75Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
43.75Single6ZG4HTL00099366ZG4-M1-HTL0009936
43.75Single7DFPSpiperone7DFP-D2-Spiperone
43.75Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
43.75Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
43.75Single7YITNalfurafine7YIT-κ-Nalfurafine
43.75Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
43.75Consensusat2_offOrthosteric Ligand7JNI-AT2-Olodanrigan
43.75Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
43.75Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
43.75Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
43.75Consensusopioid_offOrthosteric Ligandkop_off mop_off nop_off dop_off
42.86Single2Y04Salbutamol2Y04-β1-Salbutamol
42.86Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
42.86Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
42.86Single4QKXPubChem 762106284QKX-β2-PubChem 76210628
42.86Single5JQH(S)-Carazolol5JQH-β2-(S)-Carazolol
42.86Single5TGZAM65385TGZ-CB1-AM6538
42.86Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
42.86Single6H7MSalbutamol6H7M-β1-Salbutamol
42.86Single6PS1Timolol6PS1-β2-Timolol
42.86Single6PS2(S)-Alprenolol6PS2-β2-(S)-Alprenolol
42.86Single6TOTLemborexant6TOT-OX1-Lemborexant
42.86Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
42.86Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
42.86Single7CRHSKF839597CRH-D1-SKF83959-Gs/&β;1/&γ;2
42.86Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
42.86Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
42.86Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
42.86Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
42.86Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
42.86Single7T2GMitragynine pseudoindoxyl7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
42.86Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
42.86Single7WC7Lisuride7WC7-5-HT2A-Lisuride
42.86Single8GE3Epinephrine8GE3-β2-Epinephrine-Gs/&β;1/&γ;2
42.86Single8GEBEpinephrine8GEB-β2-Epinephrine-Gs/&β;1/&γ;2
42.86Single8GEEEpinephrine8GEE-β2-Epinephrine-Gs/&β;1/&γ;2
42.86Single8GEHEpinephrine8GEH-β2-Epinephrine-Gs/&β;1/&γ;2
42.86Single8GFWEpinephrine8GFW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
42.86Single8GFXEpinephrine8GFX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
42.86Single8GFYEpinephrine8GFY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
42.86Single8GFZEpinephrine8GFZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
42.86Single8GG0Epinephrine8GG0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
42.86Single8GG1Epinephrine8GG1-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
42.86Single8GG2Epinephrine8GG2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
42.86Single8GG6Epinephrine8GG6-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
42.86Single8GGJEpinephrine8GGJ-β2-Epinephrine
42.86Single8GGNEpinephrine8GGN-β2-Epinephrine
42.86Single8GGOEpinephrine8GGO-β2-Epinephrine
42.86Single8GGUEpinephrine8GGU-β2-Epinephrine
42.86Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2
42.86Single8UNNEpinephrine8UNN-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
42.86Single8UNPEpinephrine8UNP-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
42.86Single8UO4Epinephrine8UO4-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
42.86Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/&β;1/&γ;2
42.86Single8X63Mepyramine8X63-H1-Mepyramine
42.86Single8X64Desloratadine8X64-H1-Desloratadine
42.86Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
42.86Consensusadenosine_onOrthosteric Liganda1_on a2_on
42.86Consensusadrenergic_onOrthosteric Ligandbeta_on alpha_on
42.86Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
42.86Consensusdopamine_onOrthosteric Ligandd3_on d2_on d5_on d1_on
42.86Consensusnucleotide_onOrthosteric Ligandadenosine_on
42.11Single3QAKUK-4320973QAK-A2A-UK-432097
41.67Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
41.67Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
41.67Single2G87All-trans-retinal2G87-Rhodopsin-All-trans-retinal
41.67Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
41.67Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
41.67Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
41.67Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
41.67Single7SRQLSD7SRQ-5-HT2B-LSD
41.67Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
41.67Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
41.67Single8GGCEpinephrine8GGC-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
41.67Single8GGEEpinephrine8GGE-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
41.67Single8GGSEpinephrine8GGS-β2-Epinephrine
41.67Single8GGYEpinephrine8GGY-β2-Epinephrine
41.67Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
41.67Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
41.67Single8UNVEpinephrine8UNV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
41.67Single8UNXEpinephrine8UNX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
41.67Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
41.67Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
41.18Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
41.18Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
41.18Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
41.18Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
41.18Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
41.18Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
41.18Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
41.18Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
41.18Single7XJISolabegron7XJI-β3-Solabegron-Gs/&β;1/&γ;2
41.18Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
41.18Consensusbeta1_off_alloOrthosteric Ligand4BVN-β1-Cyanopindolol-Na
41.18Consensusendothelin_offOrthosteric Ligandetb_off
41.18Consensusetb_offOrthosteric Ligand5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500 5X93-ETB-K-8794
40.00Single2Y03Isoprenaline2Y03-β1-Isoprenaline
40.00Single3PXOAll-trans-retinal3PXO-Rhodopsin-All-trans-retinal
40.00Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
40.00Single5C1MBU725C1M-μ-BU72
40.00Single5CGCHTL142425CGC-mGlu5-HTL14242
40.00Single5DYSAll-trans-retinal5DYS-Rhodopsin-All-trans-retinal
40.00Single5WF5UK-4320975WF5-A2A-UK-432097
40.00Single6GDGNECA6GDG-A2A-NECA-Gs/&β;1/&γ;1
40.00Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
40.00Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
40.00Single6PS3(S)-Carvedilol6PS3-β2-(S)-Carvedilol
40.00Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
40.00Single6TP6Filorexant6TP6-OX1-Filorexant
40.00Single7BVQ(S)-Carazolol7BVQ-β1-(S)-Carazolol
40.00Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
40.00Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2
40.00Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
40.00Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
40.00Single7WC6LSD7WC6-5-HT2A-LSD
40.00Single7XKAEpinephrine7XKA-β2-Epinephrine
40.00Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
40.00Single8DZQmomSalB8DZQ-κ-momSalB-Go/&β;1/&γ;2
40.00Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
40.00Single8GEJEpinephrine8GEJ-β2-Epinephrine-Gs/&β;1/&γ;2
40.00Single8UNYEpinephrine8UNY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
40.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
40.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
40.00Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
40.00Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide 6DRX-5-HT2B-Lisuride
40.00Consensusa2a_onOrthosteric Ligand6GDG-A2A-NECA-Gs/&β;1/&γ;1
40.00Consensusadrenergic_offOrthosteric Ligandbeta_off alpha_off
40.00Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
40.00Consensusbeta2_onOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
40.00Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
40.00Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
40.00Consensusgi_adrenergicOrthosteric Ligand7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
40.00Consensusgo_opioidOrthosteric Ligand8DZQ-κ-momSalB-Go/&β;1/&γ;2
40.00Consensusgs_adrenergicOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJI-β3-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
38.89Single3NY9PubChem 9131033NY9-β2-PubChem 913103
38.89Single5ZTYAM102575ZTY-CB2-AM10257
38.89Single6PT3DPI-2876PT3-δ-DPI-287
38.89Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
38.89Single8X5YAstemizole8X5Y-H1-Astemizole
38.89Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
38.46Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
38.46Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
38.46Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
38.46Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
38.46Single4S0VSuvorexant4S0V-OX2-Suvorexant
38.46Single6AKXA4R6AKX-CCR5-A4R
38.46Single6AKYMaraviroc6AKY-CCR5-Maraviroc
38.46Single6B73PubChem 1319551386B73-κ-PubChem 131955138
38.46Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/&β;1/&γ;2
38.46Single6KUXRS-799486KUX-α2a-RS-79948
38.46Single6OBA(S)-Alprenolol6OBA-β2-(S)-Alprenolol-GTPL11074
38.46Single6TODEMPA6TOD-OX1-EMPA-Na
38.46Single6TPJSuvorexant6TPJ-OX2-Suvorexant
38.46Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/&β;1/&γ;2
38.46Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
38.46Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
38.46Single8A6CAll-trans-retinal8A6C-Rhodopsin-All-trans-retinal
38.46Single8A6DAll-trans-retinal8A6D-Rhodopsin-All-trans-retinal
38.46Single8A6EAll-trans-retinal8A6E-Rhodopsin-All-trans-retinal
38.46Single8EFOPZM218EFO-μ-PZM21-Gi1/&β;1/&γ;2
38.46Single8GEAEpinephrine8GEA-β2-Epinephrine-Gs/&β;1/&γ;2
38.46Single8GG7Epinephrine8GG7-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
38.46Single8GG9Epinephrine8GG9-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
38.46Single8GGFEpinephrine8GGF-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
38.46Single8UNOEpinephrine8UNO-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
38.46Single8UNWEpinephrine8UNW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
38.46Consensusalpha2_offOrthosteric Ligandalpha2a_off alpha2c_off
38.46Consensusalpha2a_offOrthosteric Ligand6KUX-α2a-RS-79948
38.46Consensusbeta2_off_alloOrthosteric Ligand6OBA-β2-(S)-Alprenolol-GTPL11074
38.46Consensusopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
37.50Single4DJHJDTic4DJH-κ-JDTic
37.50Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
37.50Single4RWADIPP-NH24RWA-δ-DIPP-NH2
37.50Single5V54Methiothepin5V54-5-HT1B-Methiothepin
37.50Single5X93K-87945X93-ETB-K-8794
37.50Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
37.50Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
37.50Single6H7JIsoprenaline6H7J-β1-Isoprenaline
37.50Single6J21Aprepitant6J21-NK1-Aprepitant
37.50Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
37.50Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
37.50Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2
37.50Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2
37.50Single7EW7PubChem 40774607EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
37.50Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2
37.50Single8E0GBU728E0G-μ-BU72
37.50Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
37.50Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
37.50Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
37.50Consensus5ht1_offOrthosteric Ligand5ht1b_off
37.50Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
37.50Consensusa2_onOrthosteric Liganda2a_on a2b_on
37.50Consensusgi_dopamineOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
37.50Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2
37.50Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
36.84Single4AMJ(S)-Carvedilol4AMJ-β1-(S)-Carvedilol
36.84Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
36.84Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
36.84Consensusmop_offOrthosteric Ligand7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
36.36Single2HPYAll-trans-retinal2HPY-Rhodopsin-All-trans-retinal
36.36Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
36.36Consensushca2_on_alloOrthosteric Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
36.36Consensussensory_onOrthosteric Ligandopsin_on
35.71Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
35.71Single3RZECidoxepin3RZE-H1-Cidoxepin
35.71Single3UZCPubChem 1355666093UZC-A2A-PubChem 135566609
35.71Single4MBSMaraviroc4MBS-CCR5-Maraviroc
35.71Single4ZJCSB-6740424ZJC-OX1-SB-674042
35.71Single6A94Zotepine6A94-5-HT2A-Zotepine
35.71Single6DS0Ly2660976DS0-5-HT2B-Ly266097
35.71Single6FFIMMPEP6FFI-mGlu5-MMPEP
35.71Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
35.71Single6PS5(S)-Propranolol6PS5-β2-(S)-Propranolol
35.71Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
35.71Single6TP3Nemorexant6TP3-OX1-Nemorexant
35.71Single6TPGEMPA6TPG-OX2-EMPA
35.71Single6TPNHTL66416TPN-OX2-HTL6641
35.71Single6VI4JDTic6VI4-κ-JDTic
35.71Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
35.71Single6ZG9GSK10347026ZG9-M1-GSK1034702
35.71Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
35.71Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2
35.71Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
35.71Single7F0TDopamine7F0T-D1-Dopamine-Gs/&β;1/&γ;2
35.71Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/&β;1/&γ;2
35.71Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
35.71Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
35.71Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
35.71Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
35.71Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
35.71Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
35.71Single8GDZEpinephrine8GDZ-β2-Epinephrine-Gs/&β;1/&γ;2
35.71Single8GG3Epinephrine8GG3-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.71Single8GG5Epinephrine8GG5-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.71Single8GG8Epinephrine8GG8-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.71Single8GGKEpinephrine8GGK-β2-Epinephrine
35.71Single8GGMEpinephrine8GGM-β2-Epinephrine
35.71Single8GGPEpinephrine8GGP-β2-Epinephrine
35.71Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
35.71Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2
35.71Single8UNREpinephrine8UNR-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.71Single8UNSEpinephrine8UNS-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.71Consensus5ht5_onOrthosteric Ligand5ht5a_on
35.71Consensus5ht5a_onOrthosteric Ligand7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
35.71Consensusd1_on_alloOrthosteric Ligand7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
35.71Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
35.71Consensush3_on_alloOrthosteric Ligand7F61-H3-PF-03654746-Cholesterol
35.71Consensusox1_offOrthosteric Ligand6TOT-OX1-Lemborexant 6TP4-OX1-ACT-462206 6TP6-OX1-Filorexant 6V9S-OX1-GTPL11403 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ7-OX1-SB-334867 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant
35.71Consensusox2_offOrthosteric Ligand6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant
35.71Consensussensory_offOrthosteric Ligandopsin_off
35.29Single4LDEBI1671074LDE-β2-BI167107
35.29Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
35.29Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
35.29Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
35.29Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
35.29Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
35.29Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
35.29Single7K15MKD0467K15-BLT1-MKD046-Na
35.29Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
35.29Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
35.29Single7WCNAR2314537WCN-GPR119-AR231453-Gs/&β;1/&γ;2
35.29Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
35.29Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
35.29Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
35.29Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
35.29Single8JJ8Formoterol8JJ8-β2-Formoterol
35.29Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
35.29Consensusbeta1_onOrthosteric Ligand7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
35.29Consensusblt1_offOrthosteric Ligand7K15-BLT1-MKD046-Na
35.29Consensusblt_offOrthosteric Ligandblt1_off
35.29Consensusgo_5htOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
35.29Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
35.29Consensuspeptide_offOrthosteric Ligandopioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
35.00Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
33.33Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
33.33Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
33.33Single2Y01Dobutamine2Y01-β1-Dobutamine
33.33Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
33.33Single3PQRAll-trans-retinal3PQR-Rhodopsin-All-trans-retinal-Gt(CT)
33.33Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
33.33Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
33.33Single4X1HNonyl Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
33.33Single5CGDHTL142425CGD-mGlu5-HTL14242
33.33Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
33.33Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
33.33Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
33.33Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
33.33Single6DRXLisuride6DRX-5-HT2B-Lisuride
33.33Single6FFHFenobam6FFH-mGlu5-Fenobam
33.33Single6FUFAll-trans-retinal6FUF-Rhodopsin-All-trans-retinal-Go/&β;1/&γ;2
33.33Single6H7LDobutamine6H7L-β1-Dobutamine
33.33Single6IBLArformoterol6IBL-β1-Arformoterol
33.33Single6PRZ(S)-Alprenolol6PRZ-β2-(S)-Alprenolol
33.33Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
33.33Single6PT2KGCHM076PT2-δ-KGCHM07
33.33Single7BU7BI1671077BU7-β1-BI167107
33.33Single7EZCUKA7EZC-A2A-UKA
33.33Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
33.33Single7LJCPubChem 867641037LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
33.33Single7MT8All-trans-retinal7MT8-Rhodopsin-All-trans-retinal-GRK1
33.33Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
33.33Single7SCGFH2107SCG-μ-FH210-Gi1/&β;1/&γ;2
33.33Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/&β;1/&γ;2
33.33Single7UL4Alvimopan7UL4-μ-Alvimopan
33.33Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2
33.33Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
33.33Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
33.33Single7VKTLTB47VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
33.33Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
33.33Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
33.33Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/&β;1/&γ;2
33.33Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
33.33Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
33.33Single7XZ6APD6687XZ6-GPR119-APD668-Gs/&β;1/&γ;2
33.33Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
33.33Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
33.33Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
33.33Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
33.33Single8GGBEpinephrine8GGB-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/&β;1/&γ;2
33.33Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Single8J6QBeta-hydroxybutyrate8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
33.33Single8JLZST19368JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
33.33Single8UNMEpinephrine8UNM-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
33.33Consensus5ht1a_onOrthosteric Ligand8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
33.33Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
33.33Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
33.33Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
33.33Consensusblt_onOrthosteric Ligandblt1_on
33.33Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
33.33Consensusgi_5htOrthosteric Ligand7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
33.33Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
33.33Consensusgi_hcaOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
33.33Consensusgi_hcarOrthosteric Ligandgi_hca
33.33Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
33.33Consensushca2_onOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
33.33Consensusleuko_onOrthosteric Ligandblt_on
33.33Consensusopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
33.33Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
33.33Consensustachykinin_offOrthosteric Ligandnk1_off
31.82Single7C61Ergotamine7C61-5-HT1B-Ergotamine
31.58Single5WF6UK-4320975WF6-A2A-UK-432097
31.58Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.58Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
31.58Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
31.25Single2Y00Dobutamine2Y00-β1-Dobutamine
31.25Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
31.25Single5TVNLSD5TVN-5-HT2B-LSD
31.25Single5WIUNemonapride5WIU-D4-Nemonapride
31.25Single5WIVNemonapride5WIV-D4-Nemonapride-Na
31.25Single5WQCEMPA5WQC-OX2-EMPA
31.25Single5XPRBosentan5XPR-ETB-Bosentan
31.25Single6E67BI1671076E67-β2-BI167107-Gs (fused)
31.25Single6LUQHaloperidol6LUQ-D2-Haloperidol
31.25Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
31.25Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
31.25Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
31.25Single7C4SS1P7C4S-S1P3-S1P
31.25Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
31.25Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
31.25Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
31.25Single7SBFPZM217SBF-μ-PZM21-Gi1/&β;1/&γ;2
31.25Single7SINNPS-21437SIN-CaS-NPS-2143
31.25Single7SINNPS-21437SIN-CaS-NPS-2143
31.25Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
31.25Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2
31.25Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
31.25Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
31.25Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
31.25Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
31.25Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRR-D1-Rotigotine-Gs/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
31.25Consensusd4_offOrthosteric Ligand5WIU-D4-Nemonapride
31.25Consensusd4_off_alloOrthosteric Ligand5WIV-D4-Nemonapride-Na
30.77Single3PBLEticlopride3PBL-D3-Eticlopride
30.77Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
30.77Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
30.77Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
30.77Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
30.77Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/&β;1/&γ;2
30.77Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2
30.77Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2
30.77Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/&β;1/&γ;2
30.77Single8EF6Morphine8EF6-μ-Morphine-Gi1/&β;1/&γ;2
30.77Single8GH1Epinephrine8GH1-β2-Epinephrine
30.77Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2
30.77Single8IJANiacin8IJA-HCA2-Niacin-Gi1/&β;1/&γ;2
30.77Single8IY9Niacin8IY9-HCA2-Niacin-Go/&β;1/&γ;2
30.77Single8K5BNiacin8K5B-HCA2-Niacin
30.77Consensus5ht4_onOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
30.77Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
30.77Consensusgo_adhesionOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
30.77Consensusgo_class-b2Orthosteric Ligandgo_adhesion
30.77Consensusox1_off_alloOrthosteric Ligand6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na 6TO7-OX1-Suvorexant-Na
30.43Consensusbk1_onOrthosteric Ligand7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.43Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
30.00Single4A4MAll-trans-retinal4A4M-Rhodopsin-All-trans-retinal-Gt(CT)
30.00Single4IARErgotamine4IAR-5-HT1B-Ergotamine
30.00Single5EN0All-trans-retinal5EN0-Rhodopsin-All-trans-retinal-Gt(CT)
30.00Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
30.00Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
30.00Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
30.00Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
30.00Single8WCCCyclohexylammonium ion8WCC-TA1-Cyclohexylammonium ion
30.00Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
30.00Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
29.41Single3P0GBI1671073P0G-β2-BI167107
29.41Single3SN6BI1671073SN6-β2-BI167107-Gs/&β;1/&γ;2
29.41Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
29.41Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
29.41Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
29.41Single6E59L-7607356E59-NK1-L-760735
29.41Single6J20Aprepitant6J20-NK1-Aprepitant
29.41Single6NI3BI1671076NI3-β2-BI167107-Gs/&β;1/&γ;2
29.41Single6WGTLSD6WGT-5-HT2A-LSD
29.41Single7B6WCyclazosin7B6W-α1b-Cyclazosin
29.41Single7EPENAM5637EPE-mGlu-NAM563
29.41Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
29.41Single7JVPSKF839597JVP-D1-SKF83959-Gs/&β;1/&γ;2
29.41Single7P2L4YI7P2L-mGlu5-4YI
29.41Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2
29.41Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
29.41Single7XTQR3997XTQ-GPBA-R399-Gs/&β;1/&γ;2
29.41Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/&β;1/&γ;2
29.41Single8EFLSR170188EFL-μ-SR17018-Gi1/&β;1/&γ;2
29.41Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.41Single8JD0J9R8JD0-mGlu2; mGlu3-Glutamate-J9R
29.41Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
29.41Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
29.41Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
29.41Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
29.41Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
29.41Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
29.41Single8X79MRE-2698X79-I2-MRE-269-Gs/&β;1/&γ;2
29.41Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
29.41Consensus5ht1b_onOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
29.41Consensus5ht5_offOrthosteric Ligand5ht5a_off
29.41Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
29.41Consensusalpha1b_offOrthosteric Ligand7B6W-α1b-Cyclazosin
29.41Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
29.41Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A2A-NECA-Gs/&β;1/&γ;1 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
29.41Consensusgs_ffaOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2 8GDB-EP4-PGE2-Gs/&β;1/&γ;2
29.41Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
29.41Consensusnk1_offOrthosteric Ligand6J20-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
29.41Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
29.17Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
28.57Single5DHHSB-6121115DHH-NOP-SB-612111
28.57Single5WS3EMPA5WS3-OX2-EMPA
28.57Single6HLOAprepitant6HLO-NK1-Aprepitant
28.57Single6OYAAll-trans-retinal6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
28.57Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
28.57Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
28.57Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2
28.57Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
28.57Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;1
28.57Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
28.57Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
28.57Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
28.57Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
28.57Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
28.57Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
28.57Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
28.57Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2
28.57Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
28.57Single8GEDEpinephrine8GED-β2-Epinephrine-Gs/&β;1/&γ;2
28.57Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/&β;1/&γ;2
28.57Single8IHKAcifran8IHK-HCA3-Acifran
28.57Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/&β;1/&γ;2
28.57Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
28.57Single8UNLEpinephrine8UNL-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
28.57Single8UNTEpinephrine8UNT-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
28.57Single8UNUEpinephrine8UNU-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
28.57Single8UO1Epinephrine8UO1-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
28.57Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
28.57Consensus5ht2c_onOrthosteric Ligand8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
28.57Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
28.57Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
28.57Consensusgs_5htOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2 7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2 7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
28.57Consensusgt_class-aOrthosteric Ligandgt_opsin
28.57Consensusgt_opsinOrthosteric Ligandgt_sensory
28.57Consensusgt_sensoryOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
28.57Consensusmelatonin_onOrthosteric Ligandmt1_on mt2_on
28.57Consensusmglu_onOther Ligandmglu2_on mglu4_on
28.57Consensusorexin_offOrthosteric Ligandox2_off ox1_off
28.00Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.78Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
27.78Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
27.78Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
27.78Single6HLPNetupitant6HLP-NK1-Netupitant
27.78Single6MXTSalmeterol6MXT-β2-Salmeterol
27.78Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
27.78Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
27.78Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/&β;1/&γ;2
27.78Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/&β;1/&γ;2
27.78Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.78Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
27.78Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
27.78Single8IJDMK68928IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
27.78Single8JJLOlodaterol8JJL-β2-Olodaterol
27.78Single8JWYPubChem 1684517108JWY-A2A-PubChem 168451710
27.78Single8JWZAB9288JWZ-A2A-AB928-Na
27.78Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/&β;1/&γ;2
27.78Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
27.78Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
27.78Single8WU1KCA8WU1-CB1-KCA-Arrestin1
27.78Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg3_on
27.78Consensusclass-b2_onOrthosteric Ligandadgrg_on
27.78Consensusgi_class-fOther Ligandgi_frizzled
27.78Consensusgi_frizzledOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
27.78Consensusgpr119_onOrthosteric Ligand7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
27.78Consensusgs_bileacidOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
27.78Consensusgs_steroidOrthosteric Ligandgs_bileacid
27.78Consensusgs_trhOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
27.78Consensusleuko_offOrthosteric Ligandblt_off cyslt_off
27.78Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
27.78Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
27.78Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
27.27Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
27.27Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
27.27Single7WC4Serotonin7WC4-5-HT2A-Serotonin
27.27Single7XKEBetahydroxyandrosterone7XKE-ADGRG2-Betahydroxyandrosterone-chim(NtGi1-Gs)/&β;1/&γ;2
27.27Consensusgabab_offOther Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
27.27Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
26.67Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
26.67Single6IQLL7458706IQL-D4-L745870
26.67Single6TPKRetosiban6TPK-OT-Retosiban
26.67Single6V9SGTPL114036V9S-OX1-GTPL11403
26.67Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/&β;1/&γ;2
26.67Single7JOZVFP7JOZ-D1-VFP-Gs/&β;1/&γ;2
26.67Single7T32ZM2413857T32-A2A-ZM241385
26.67Single7VODCariprazine7VOD-5-HT2A-Cariprazine
26.67Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
26.67Single8GGLEpinephrine8GGL-β2-Epinephrine
26.67Single8GURPubChem 1048958GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2
26.67Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
26.67Single8JERAcipimox8JER-HCA2-Acipimox-Go/&β;1/&γ;2
26.67Single8JHNMMF8JHN-HCA2-MMF-Go/&β;1/&γ;2
26.67Single8JIMMMF8JIM-HCA2-MMF-Gi1/&β;1/&γ;2
26.67Single8K5CAcipimox8K5C-HCA2-Acipimox
26.67Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
26.67Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
26.67Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
26.67Consensusgi_melatoninOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
26.67Consensushca_onOrthosteric Ligandhca2_on hca3_on
26.67Consensushcar_onOrthosteric Ligandhca_on
26.67Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
26.67Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
26.67Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
26.67Consensuss1p_offOrthosteric Ligands1p1_off
26.67Consensusvasopressin-ot_offOrthosteric Ligandot_off
26.32Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
26.32Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
26.32Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
26.32Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
26.32Single6DDFDamgo6DDF-μ-Damgo-Gi1/&β;1/&γ;2
26.32Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
26.32Single7UM4AS26747237UM4-5-HT5A-AS2674723
26.32Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
26.32Single7XK2MK68927XK2-HCA2-MK6892-Gi1/&β;1/&γ;2
26.32Single8ID8TUG-8918ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
26.32Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.32Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
26.32Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
26.32Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.32Consensus5ht5a_offOrthosteric Ligand7UM4-5-HT5A-AS2674723
26.32Consensusbileacid_onOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
26.32Consensusfpa_onOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.32Consensusgs_orexinOrthosteric Ligand7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
26.32Consensusorexin_onOrthosteric Ligandox2_on
26.32Consensussteroid_onOrthosteric Ligandbileacid_on
26.09Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
25.93Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
25.93Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
25.00Single2Y02Carmoterol2Y02-β1-Carmoterol
25.00Single4YAYZD-71554YAY-AT1-ZD-7155
25.00Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
25.00Single5DHGPubChem 250014125DHG-NOP-PubChem 25001412
25.00Single6GPSMK08126GPS-CCR2-MK0812
25.00Single6IIVDaltroban6IIV-TP-Daltroban
25.00Single6OY9All-trans-retinal6OY9-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
25.00Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
25.00Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
25.00Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
25.00Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
25.00Single7F83PF-051904577F83-Ghrelin-PF-05190457
25.00Single7KH0Acyclovir triphosphate7KH0-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single7MTBAll-trans-retinal7MTB-Rhodopsin-All-trans-retinal-GRK1
25.00Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
25.00Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
25.00Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/&β;1/&γ;2
25.00Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Single7XN9L-054,5227XN9-SST2-L-054,522
25.00Single7XY6PubChem 117178317XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
25.00Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
25.00Single8CU6LJ-45178CU6-A2A-LJ-4517
25.00Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/&β;1/&γ;2
25.00Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/&β;1/&γ;2
25.00Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
25.00Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
25.00Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
25.00Single8K5DGSK2560738K5D-HCA2-GSK256073
25.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
25.00Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
25.00Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
25.00Consensushca3_onOrthosteric Ligand8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
25.00Consensuslpl_offOrthosteric Ligands1p_off lpa_off
25.00Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
25.00Consensustp_offOrthosteric Ligand6IIV-TP-Daltroban 6IIU-TP-Ramatroban
24.00Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
24.00Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
23.81Single7QA8Peptide7QA8-STE2-Peptide
23.81Single7QA8Peptide7QA8-STE2-Peptide
23.81Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
23.81Single8J6RMK68928J6R-HCA2-MK6892-Gi1/&β;1/&γ;2
23.81Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
23.81Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
23.81Consensusclass-d_offOrthosteric Ligandste2_off
23.53Single4WW3All-trans-retinal4WW3-Rhodopsin-All-trans-retinal
23.53Single5N2RPubChem 92460631; psb365N2R-A2A-PubChem 92460631; psb36-Na
23.53Single5N2SPSB365N2S-A1-PSB36
23.53Single5NM2ZM2413855NM2-A2A-ZM241385-Na
23.53Single6D26Fevipiprant6D26-DP2-Fevipiprant
23.53Single6DDEDamgo6DDE-μ-Damgo-Gi1/&β;1/&γ;2
23.53Single6GPXMK08126GPX-CCR2-MK0812
23.53Single7CFNINT-7777CFN-GPBA-INT-777-Gs/&β;1/&γ;2
23.53Single7CKXA776367CKX-D1-A77636-Gs/&β;1/&γ;2
23.53Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
23.53Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2
23.53Single8GDCPGE28GDC-EP3-PGE2-Gi1/&β;1/&γ;2
23.53Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
23.53Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
23.53Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
23.53Consensuscb2_onOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
23.53Consensusep3_onOrthosteric Ligand8GDC-EP3-PGE2-Gi1/&β;1/&γ;2
23.08Single3UZAGTPL92363UZA-A2A-GTPL9236
23.08Single5WKTOctyl Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
23.08Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2
23.08Single7MT9All-trans-retinal7MT9-Rhodopsin-All-trans-retinal-GRK1
23.08Single7MTAAll-trans-retinal7MTA-Rhodopsin-All-trans-retinal-GRK1
23.08Single7WC5Psilocin7WC5-5-HT2A-Psilocin
22.73Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
22.73Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
22.73Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
22.73Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
22.73Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
22.73Consensusalpha1_offOrthosteric Ligandalpha1a_off alpha1b_off
22.22Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
22.22Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
22.22Single5XR8AM8415XR8-CB1-AM841
22.22Single5XRAAM115425XRA-CB1-AM11542
22.22Single6IGLIRL16206IGL-ETB-IRL1620
22.22Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
22.22Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
22.22Single7CKYPW04647CKY-D1-PW0464-Gs/&β;1/&γ;2
22.22Single7JV5SKF812977JV5-D1-SKF81297-Gs/&β;1/&γ;2
22.22Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
22.22Single7TUYGSK682753A7TUY-GPR183-GSK682753A
22.22Single7W41PD1762527W41-BB2-PD176252
22.22Single7WV9PubMed 1048957WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
22.22Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
22.22Single8FEGPRD_0025178FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
22.22Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2
22.22Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
22.22Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
22.22Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
22.22Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2
22.22Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2
22.22Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/&β;1/&γ;2
22.22Consensusadenosine_offOrthosteric Liganda1_off a2_off
22.22Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
22.22Consensusbombesin_offOrthosteric Ligandbb2_off
22.22Consensusffa4_onOrthosteric Ligand8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
22.22Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
22.22Consensuslpa_offOrthosteric Ligandlpa1_off
22.22Consensuss1p2_onOrthosteric Ligand7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
22.22Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
21.74Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
21.74Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;2
21.74Consensusangiotensin_onOrthosteric Ligandat1_on
21.74Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
21.74Consensusgi_chemerinOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
21.74Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
21.43Single3AYMAll-trans-retinal3AYM-Rhodopsin-All-trans-retinal
21.43Single6HLLCP999946HLL-NK1-CP99994
21.43Single6QNOAll-trans-retinal6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
21.43Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
21.43Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
21.43Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2
21.43Single8JILNiacin8JIL-HCA2-Niacin-Gi1/&β;1/&γ;2
21.43Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
21.43Single8X2K5YM8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
21.43Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
21.43Consensusmt1_onOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
21.43Consensusmt2_onOrthosteric Ligand7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
21.05Single4N4WSANT-14N4W-SMO-SANT-1
21.05Single5X33BIIL2605X33-BLT1-BIIL260
21.05Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
21.05Single6IIURamatroban6IIU-TP-Ramatroban
21.05Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
21.05Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
21.05Single7XMTJ-21567XMT-SST4-J-2156-Gi1/&β;1/&γ;2
21.05Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
21.05Single8GCPPGE28GCP-EP4-PGE2-Gi1/&β;1/&γ;2
21.05Single8I95EP548I95-C3aB-EP54-Go/&β;1/&γ;2
21.05Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2
21.05Single8J6DEP1418J6D-C3aB-EP141-Go/&β;1/&γ;2
21.05Consensuscannabinoid_onOrthosteric Ligandcb1_on cb2_on
21.05Consensuscb1_onOrthosteric Ligand8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
21.05Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
21.05Consensusdp_offOrthosteric Liganddp2_off
21.05Consensusgi_cannabinoidOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
21.05Consensusgi_prostanoidOrthosteric Ligand8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GDC-EP3-PGE2-Gi1/&β;1/&γ;2 8GCM-EP4-L902688-Gi1/&β;1/&γ;2
21.05Consensusprostanoid_onOrthosteric Ligandep_on fpa_on
20.83Single6JODAngiotensin II6JOD-AT2-Angiotensin II
20.83Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
20.83Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
20.83Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
20.83Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
20.83Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.83Single8IHFMK68928IHF-HCA2-MK6892-Gi1/&β;1/&γ;2
20.83Single8J6IMK68928J6I-HCA2-MK6892-Gi1/&β;1/&γ;2
20.83Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
20.83Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
20.83Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single2X72All-trans-retinal2X72-Rhodopsin-All-trans-retinal-Gt(CT)
20.00Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
20.00Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
20.00Single3VGAZM2413853VGA-A2A-ZM241385-Antibody
20.00Single5U09Taranabant5U09-CB1-Taranabant
20.00Single6K1QIRL25006K1Q-ETB-IRL2500
20.00Single6ME2Ramelteon6ME2-MT1-Ramelteon
20.00Single6NWEOctyl Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
20.00Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
20.00Single7F8ULintitript7F8U-CCKA-Lintitript
20.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
20.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
20.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
20.00Single7TUZ7alpha,25-dihydroxycholesterol7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
20.00Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
20.00Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
20.00Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
20.00Single7XRRLemborexant7XRR-OX2-Lemborexant
20.00Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
20.00Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
20.00Single8GAGYVF8GAG-CB1-YVF-Gi1/&β;1/&γ;2
20.00Single8GNGIstradefylline8GNG-A2A-Istradefylline
20.00Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/&β;1/&γ;2
20.00Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2
20.00Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
20.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
20.00Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Consensusa2a_off_alloOrthosteric Ligand6ZDR-A2A-HMS1413f12-Na 6GT3-A2A-Imaradenant-Na 8CU7-A2A-LJ-4517-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PubChem 92460631; psb36-Na 5MZJ-A2A-Theophylline-Na 5OLO-A2A-Tozadenant-Na 5OLH-A2A-Vipadenant-Na 5NM4-A2A-ZM241385-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5MZP-A2A-Caffeine-Na 8CIC-A2A-Etrumadenant-Na
20.00Consensusbombesin_onOrthosteric Ligandbb2_on bb1_on
20.00Consensusep4_onOrthosteric Ligand7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2
20.00Consensusffa4_on_alloOrthosteric Ligand8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Consensusgs_bradykininOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Consensusgs_lipidOrthosteric Ligandgs_ffa gs_prostanoid
20.00Consensusgs_prostanoidOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
19.23Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
19.23Consensusgi_neuromedinOrthosteric Ligand7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
19.05Single5EE7MK08935EE7-Glucagon-MK0893
19.05Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.05Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
19.05Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
19.05Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
19.05Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
19.05Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.05Single8IYHMK68928IYH-HCA2-MK6892-Go/&β;1/&γ;2
19.05Single8XZFWN5618XZF-Apelin-WN561-Gi1/&β;1/&γ;2
19.05Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2 8I95-C3aB-EP54-Go/&β;1/&γ;2
19.05Consensusclass-d_offOrthosteric Ligandste2_off
19.05Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
19.05Consensusfpr2-alx_onOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
19.05Consensusgs_adgrOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
19.05Consensusgs_class-b2Orthosteric Ligandgs_adgr
19.05Consensuslpl_onOrthosteric Ligands1p_on lpa_on
19.05Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
18.75Single5IU7Q274563465IU7-A2A-Q27456346-Na
18.75Single5JTBZM2413855JTB-A2A-ZM241385
18.75Single5K2BZM2413855K2B-A2A-ZM241385-Na
18.75Single5TE3Octyl Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
18.75Single6AQFZM2413856AQF-A2A-ZM241385
18.75Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
18.75Single6MH8ZM2413856MH8-A2A-ZM241385
18.75Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
18.75Single7AROLUF58337ARO-A2A-LUF5833-Na
18.75Single7BB6Acyclovir triphosphate7BB6-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
18.75Single7VVOPTH7VVO-PTH1-PTH-Gs/&β;1/&γ;2
18.75Single7XOVSR1461317XOV-CCKA-SR146131-Gs/&β;1/&γ;2
18.75Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
18.75Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.75Single8GCML9026888GCM-EP4-L902688-Gi1/&β;1/&γ;2
18.75Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2
18.75Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.75Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
18.52Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
18.52Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
18.52Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
18.52Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
18.52Consensusendothelin_onOrthosteric Ligandetb_on eta_on
18.52Consensusgo_class-b1Orthosteric Ligandgo_crf
18.52Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
18.52Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
18.18Single5MZPCaffeine5MZP-A2A-Caffeine-Na
18.18Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
18.18Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
18.18Single7F8XNN90567F8X-CCKA-NN9056
18.18Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
18.18Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
18.18Single8G59TUG-8918G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
18.18Single8GHVPubChem 1459649038GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
18.18Single8WCBCyclohexylammonium ion8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.18Consensusfpr-alx_onOrthosteric Ligandfpr1-alx_on fpr2-alx_on
18.18Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
18.18Consensusnmur1_onOrthosteric Ligand7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.18Consensussst2_onOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
18.18Consensussst_onOrthosteric Ligandsst2_on sst4_on
18.18Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
17.86Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
17.86Consensuscrf1_onOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
17.86Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
17.86Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
17.86Consensusgs_endothelinOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.86Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
17.86Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
17.65Single3EMLZM2413853EML-A2A-ZM241385
17.65Single4EIYZM2413854EIY-A2A-ZM241385-Na
17.65Single5IU8Q274563475IU8-A2A-Q27456347-Na
17.65Single5K2AZM2413855K2A-A2A-ZM241385-Na
17.65Single5OLGZM2413855OLG-A2A-ZM241385-Na
17.65Single5UENDU1725UEN-A1-DU172
17.65Single5UIGJ3.651.884G5UIG-A2A-J3.651.884G
17.65Single5VRAZM2413855VRA-A2A-ZM241385-Na
17.65Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
17.65Single6D27CAY104716D27-DP2-CAY10471
17.65Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2
17.65Single6S0LZM2413856S0L-A2A-ZM241385
17.65Single7CFMP3957CFM-GPBA-P395-Gs/&β;1/&γ;2
17.65Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
17.65Single7PYRPSB-21157PYR-A2A-PSB-2115
17.65Single7V3ZPubMed 1048957V3Z-CB1-PubMed 104895
17.65Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
17.65Single8EFQDamgo8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
17.65Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
17.65Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/&β;1/&γ;2
17.65Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-alpha-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
17.65Consensusa2_offOrthosteric Liganda2a_off
17.65Consensusa2a_offOrthosteric Ligand8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 5UIG-A2A-J3.651.884G 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-PubChem 168451710 5K2D-A2A-ZM241385
17.65Consensuscb1_on_alloOrthosteric Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
17.65Consensushcar_offOrthosteric Ligandsuccinate_off
17.65Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
17.65Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
17.65Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
17.65Consensusprostanoid_offOrthosteric Ligandep_off tp_off dp_off
17.65Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
17.39Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
17.39Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
17.39Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
17.39Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.39Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
17.39Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
17.39Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
17.39Consensuscx3cr_onOrthosteric Ligandcx3cr1_on
17.39Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
17.24Single5GLHEndothelin-15GLH-ETB-Endothelin-1
17.24Single6IGKEndothelin-36IGK-ETB-Endothelin-3
17.24Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
17.24Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
17.24Consensusgs_crfOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
16.67Single5IUAQ274563485IUA-A2A-Q27456348-Na
16.67Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
16.67Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
16.67Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
16.67Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
16.67Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
16.67Single6LPLZM2413856LPL-A2A-ZM241385-Na
16.67Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
16.67Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
16.67Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
16.67Single6S0QZM2413856S0Q-A2A-ZM241385
16.67Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
16.67Single6W25SHU91196W25-MC4-SHU9119-Ca
16.67Single6WQAZM2413856WQA-A2A-ZM241385-Na
16.67Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
16.67Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
16.67Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
16.67Single7RM5ZM2413857RM5-A2A-ZM241385-Na
16.67Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
16.67Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
16.67Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
16.67Single7YXAONO-54306087YXA-S1P5-ONO-5430608
16.67Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
16.67Single8FYNZM2413858FYN-A2A-ZM241385-Na
16.67Single8GDAL9026888GDA-EP4-L902688-Gs/&β;1/&γ;2
16.67Single8GNEKW-63568GNE-A2A-KW-6356-Na
16.67Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
16.67Single8PWNTheophylline8PWN-A2A-Theophylline
16.67Single8QOTNanobody E8QOT-μ-Nanobody E
16.67Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
16.67Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
16.67Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
16.67Consensusccr2_off_alloOther Ligand5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
16.67Consensuscx3cr1_onOrthosteric Ligand7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
16.67Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
16.67Consensusep_offOrthosteric Ligandep4_off
16.67Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
16.67Consensusgi_formylpeptideOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
16.13Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
16.13Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
16.13Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
16.00Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
16.00Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
16.00Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
16.00Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
16.00Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.00Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
16.00Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
16.00Consensusclass-d_onOrthosteric Ligandste2_on
16.00Consensusgi_class-dOrthosteric Ligandgi_ste
16.00Consensusgi_somatostatinOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
16.00Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
16.00Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
15.79Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
15.79Single7FEEPubMed 1048957FEE-CB1-PubMed 104895-ZCZ011
15.79Single7PX4PSB-21137PX4-A2A-PSB-2113
15.79Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
15.79Single8GDBPGE28GDB-EP4-PGE2-Gs/&β;1/&γ;2
15.79Single8GUSHU-3088GUS-CB2-HU-308-Gi1/&β;1/&γ;2
15.79Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
15.79Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.79Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
15.79Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
15.79Consensuscck_onOrthosteric Ligandccka_on cckb_on
15.79Consensuscyslt1_off_ortoalloOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
15.79Consensusgi_ffaOrthosteric Ligand8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
15.79Consensusgs_compl-peptideOrthosteric Ligand8I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.79Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
15.79Consensuslpa_onOrthosteric Ligandlpa1_on
15.79Consensusnpy_offOrthosteric Ligandnpy2_off npy1_off
15.79Consensussst4_onOrthosteric Ligand7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
15.62Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
15.62Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
15.62Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
15.38Single3RFMCaffeine3RFM-A2A-Caffeine
15.38Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
15.38Single6TQ9SB-4081246TQ9-OX1-SB-408124
15.38Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
15.38Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
15.38Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
15.38Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
15.38Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
15.38Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
15.38Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
15.38Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
15.38Single7XKDBetahydroxyandrosterone7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
15.38Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
15.38Single8A2OTheophylline8A2O-A2A-Theophylline-Na
15.38Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
15.38Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
15.38Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.38Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.38Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
15.38Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
15.38Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
15.38Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.38Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
15.15Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
15.15Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
15.15Consensuspth_onOrthosteric Ligandpth1_on pth2_on
15.00Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
15.00Single6KQIPubMed 1048956KQI-CB1-PubMed 104895-ORG27569
15.00Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
15.00Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.00Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
15.00Single7Y24Octreotide7Y24-SST2-Octreotide-Go/&β;1/&γ;2
15.00Single7Y66BM2137Y66-C5a1-BM213-Gi1/&β;1/&γ;2
15.00Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2
15.00Consensuscb1_off_alloOrthosteric Ligand6KQI-CB1-PubMed 104895-ORG27569
15.00Consensusep_onOrthosteric Ligandep4_on ep2_on ep3_on
14.81Single6FJ3PTH6FJ3-PTH1-PTH
14.81Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/&β;1/&γ;2
14.81Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
14.81Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
14.81Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
14.81Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
14.81Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
14.81Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
14.81Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
14.81Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
14.81Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.81Consensusbb1_onOrthosteric Ligand8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.81Consensusclass-d_onOrthosteric Ligandste2_on
14.81Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
14.81Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
14.29Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
14.29Single3OE6IT1t3OE6-CXCR4-IT1t
14.29Single3OE8IT1t3OE8-CXCR4-IT1t
14.29Single6ME5Agomelatine6ME5-MT1-Agomelatine
14.29Single6ME9Ramelteon6ME9-MT2-Ramelteon
14.29Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
14.29Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
14.29Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
14.29Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
14.29Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
14.29Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
14.29Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
14.29Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
14.29Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
14.29Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
14.29Single8EITDoconexent8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
14.29Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
14.29Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
14.29Single8WRZ8D08WRZ-CB1-8D0-Arrestin1
14.29Consensusadgrg2_onOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Consensuscckb_onOrthosteric Ligand7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
14.29Consensusetb_onOrthosteric Ligand8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
14.29Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
14.29Consensusgi_class-dOrthosteric Ligandgi_ste
14.29Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
14.29Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
14.29Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
14.29Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Consensusot_onOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
14.29Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
13.79Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
13.79Single6LMLGlucagon6LML-Glucagon-Glucagon
13.79Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
13.79Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
13.79Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
13.79Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
13.79Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
13.79Single7VGXNeuropeptide Y7VGX-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
13.79Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
13.79Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
13.79Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
13.79Single8IY6Endothelin-18IY6-ETB-Endothelin-1
13.79Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
13.64Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
13.64Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
13.64Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
13.64Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
13.64Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
13.64Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
13.64Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
13.64Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
13.64Consensusgo_vasopressinOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
13.64Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
13.64Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
13.33Single3OE9IT1t3OE9-CXCR4-IT1t
13.33Single5L7IVismodegib5L7I-SMO-Vismodegib
13.33Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
13.33Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
13.33Single6TP4ACT-4622066TP4-OX1-ACT-462206
13.33Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
13.33Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
13.33Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
13.33Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
13.16Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
13.04Single4XT1Fractalkine4XT1-US28-Fractalkine
13.04Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
13.04Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.04Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
13.04Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
13.04Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
13.04Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
13.04Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
13.04Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
13.04Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
12.90Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
12.90Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
12.90Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
12.90Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
12.90Consensusglp_onOrthosteric Ligandglp1_on glp2_on
12.90Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
12.50Single3ODUIT1t3ODU-CXCR4-IT1t
12.50Single3PWHZM2413853PWH-A2A-ZM241385
12.50Single3VG9ZM2413853VG9-A2A-ZM241385-Antibody
12.50Single5K2DZM2413855K2D-A2A-ZM241385
12.50Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
12.50Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
12.50Single5ZKQABT-4915ZKQ-PAF-ABT-491
12.50Single6JZHZM2413856JZH-A2A-ZM241385-Na
12.50Single6PS7ZM2413856PS7-A2A-ZM241385-Na
12.50Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
12.50Single7BR3Elagolix7BR3-GnRH1-Elagolix
12.50Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
12.50Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/&β;1/&γ;2
12.50Single7SHEPI; PE7SHE-GPR158-PI; PE
12.50Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
12.50Single7W0OElabela7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
12.50Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
12.50Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
12.50Single8HMPPubChem 699214798HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
12.50Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
12.50Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.50Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
12.50Single8U8FPML8U8F-GPR3-PML-Gs/&β;1/&γ;2
12.50Consensusffa3_on_alloOrthosteric Ligand8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
12.50Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
12.50Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
12.50Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
12.50Consensussmo_on_alloOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
12.50Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
12.12Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
12.12Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
12.12Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
12.12Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
12.12Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
12.00Single3OE0CVX153OE0-CXCR4-CVX15
12.00Single7F4DAlpha-MSH7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
12.00Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
12.00Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
12.00Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
12.00Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
12.00Consensusmc5_onOrthosteric Ligand8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
11.76Single3REYPubChem 56973REY-A2A-PubChem 5697
11.76Single5IU4ZM2413855IU4-A2A-ZM241385-Na
11.76Single5IUBQ274563445IUB-A2A-Q27456344-Na
11.76Single5K2CZM2413855K2C-A2A-ZM241385-Na
11.76Single5NLXZM2413855NLX-A2A-ZM241385-Na
11.76Single5NM4ZM2413855NM4-A2A-ZM241385-Na
11.76Single5UVIZM2413855UVI-A2A-ZM241385
11.76Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
11.76Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
11.76Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
11.76Single6ZDVPubChem 9840736ZDV-A2A-PubChem 984073-Na
11.76Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
11.76Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
11.76Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
11.76Single8HQN9(S)-HODE8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
11.76Single8K2WAMG4878K2W-CXCR3-AMG487
11.76Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/&β;1/&γ;2
11.76Consensusffa2_onOrthosteric Ligand8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
11.76Consensusgnrh_offOrthosteric Ligandgnrh1_off
11.54Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
11.54Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
11.54Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
11.54Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
11.54Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
11.54Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
11.54Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
11.54Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
11.54Consensusnmur2_onOrthosteric Ligand7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.54Consensusnmur_onOrthosteric Ligandnmur1_on nmur2_on
11.54Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
11.11Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
11.11Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
11.11Single6LPJZM2413856LPJ-A2A-ZM241385-Na
11.11Single6LPKZM2413856LPK-A2A-ZM241385-Na
11.11Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
11.11Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
11.11Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.11Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
11.11Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
11.11Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
11.11Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
11.11Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
11.11Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
11.11Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
11.11Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
11.11Single8EJCTAK-8758EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
11.11Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
11.11Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
11.11Consensuscck_offOrthosteric Ligandccka_off
11.11Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
11.11Consensusclass-c_offOther Ligandgabab_off mglu_off
11.11Consensusffa1_onOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.11Consensusffa_onOrthosteric Ligandffa4_on ffa1_on ffa2_on ffa3_on
11.11Consensusfsh_on_alloOther Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
11.11Consensusgs_melanocortinOrthosteric Ligand7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2
11.11Consensusgs_neuromedinOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.11Consensusp2y12_offOrthosteric Ligand4NTJ-P2Y12-AZD1283 7PP1-P2Y12-Selatogrel
11.11Consensussmo_offOrthosteric Ligand5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
10.81Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
10.71Single4XT3Fractalkine4XT3-US28-Fractalkine
10.71Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
10.71Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
10.71Single7D3SSecretin7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
10.71Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
10.71Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
10.71Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
10.71Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
10.71Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
10.71Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
10.71Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
10.53Single4NTJAZD12834NTJ-P2Y12-AZD1283
10.53Single4PHUFasiglifam4PHU-FFA1 (GPR40)-Fasiglifam
10.53Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
10.53Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
10.53Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
10.53Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
10.53Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.53Single7Y27Somatostatin-147Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.53Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
10.53Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
10.53Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
10.53Single8ID9Eicosapentaenoic acid8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
10.53Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
10.53Consensusgs_sstOrthosteric Ligand7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.53Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
10.34Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
10.34Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
10.34Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
10.34Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
10.34Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
10.34Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
10.26Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
10.00Single5TZR-5TZR-FFA1 (GPR40)-MK8666
10.00Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
10.00Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2
10.00Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
10.00Single7XOWGastrin7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
10.00Single7XOXCholecystokinin-87XOX-CCKB-Cholecystokinin-8-Gq/&β;1/&γ;2
10.00Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.00Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2
10.00Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
10.00Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
10.00Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
10.00Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
10.00Consensuschemerin_onOrthosteric Ligandcml1_on
10.00Consensuscml1_onOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
10.00Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
10.00Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
10.00Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
10.00Consensusrelaxin_onOrthosteric Ligandrxfp4_on
10.00Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
9.68Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
9.68Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
9.68Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
9.68Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
9.52Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
9.52Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
9.52Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1
9.52Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2
9.52Single7SHEPI; PE7SHE-GPR158-PI; PE
9.52Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
9.52Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.52Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2
9.52Single8IBUErythromycin A8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.52Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
9.52Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
9.52Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
9.09Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
9.09Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
9.09Single7CX2PGE27CX2-EP2-PGE2-Gs/&β;1/&γ;2
9.09Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2
9.09Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2
9.09Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
9.09Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
9.09Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.09Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
9.09Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
9.09Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
9.09Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
9.09Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
9.09Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
9.09Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
9.09Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
9.09Consensusc5a1_off_ortoalloOrthosteric Ligand6C1Q-C5a1-PMX53-NDT9513727 6C1R-C5a1-PMX53-Avacopan; Na
9.09Consensuscyslt2_offOrthosteric Ligand6RZ6-CysLT2-ONO-2570366 6RZ9-CysLT2-ONO-2770372 6RZ8-CysLT2-ONO-2080365
9.09Consensuscyslt_offOrthosteric Ligandcyslt2_off
9.09Consensusep2_onOrthosteric Ligand7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
8.82Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
8.82Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
8.70Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
8.70Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
8.70Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.70Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
8.70Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
8.70Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.70Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
8.70Consensusgs_bombesinOrthosteric Ligand8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.70Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.70Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
8.57Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
8.33Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
8.33Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
8.33Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
8.33Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
8.33Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
8.33Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
8.11Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
8.00Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
8.00Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
8.00Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
8.00Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
8.00Single7SK5CXCL127SK5-ACKR3-CXCL12
8.00Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.00Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
8.00Consensussst_offOrthosteric Ligandsst2_off
7.89Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
7.69Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1
7.69Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
7.69Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
7.69Single7XNACYN1548067XNA-SST2-CYN154806
7.69Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
7.69Consensusclass-c_onOther Ligandgabab_on mglu_on
7.69Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
7.69Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.69Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.69Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
7.69Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
7.41Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
7.41Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
7.41Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
7.41Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
7.14Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
7.14Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
7.14Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.90Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
6.90Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
6.90Single7SK3CXCL127SK3-ACKR3-CXCL12
6.90Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
6.90Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
6.90Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
6.90Consensusghrh_onOrthosteric Ligand7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
6.67Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
6.67Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
6.67Single6LI0GTPL98046LI0-GPR52-GTPL9804
6.67Single6OBAGTPL110746OBA-β2-(S)-Alprenolol-GTPL11074
6.67Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
6.67Single8F76-8F76-OR51E2-Gs/&β;1/&γ;2
6.67Consensusadgrg3_onOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
6.67Consensusbeta2_off_alloOther Ligand6OBA-β2-(S)-Alprenolol-GTPL11074
6.67Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
6.67Consensussmo_off_alloOrthosteric Ligand6D32-SMO-Cyclopamine-Cyclopamine
6.45Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
6.25Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
6.25Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
6.25Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
6.25Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
6.25Single7XKFBetahydroxyandrosterone7XKF-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
6.25Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
6.25Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/&β;1/&γ;2
6.25Single8J6QCompound 9n8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
6.25Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
6.25Consensusclass-t_onOrthosteric Ligandtaste2_on
6.25Consensusgs_class-tOrthosteric Ligandgs_taste
6.25Consensusgs_tasteOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
6.25Consensushca2_on_alloOther Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
6.25Consensusm4_on_alloOther Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
6.25Consensussmo_on_alloOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
6.25Consensustaste2_onOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
6.06Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
6.06Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
5.88Single4K5YCP-3763954K5Y-CRF1-CP-376395
5.88Single6C1QNDT95137276C1Q-C5a1-PMX53-NDT9513727
5.88Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
5.88Single7F8YDevazepide7F8Y-CCKA-Devazepide
5.88Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
5.88Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
5.88Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
5.88Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
5.88Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2
5.88Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
5.88Consensusm2_on_alloOther Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
5.88Consensusp2y_offOrthosteric Ligandp2y1_off p2y12_off
5.71Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
5.56Single5O9HNDT95137275O9H-C5a1-NDT9513727
5.56Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
5.56Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
5.56Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
5.56Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.56Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
5.56Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
5.56Single8IYXYL-3658IYX-GPR34-YL-365
5.56Single8JD6N-(3-chlorophenyl)pyridine-2-carboxamide8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
5.56Single8K4NVF08K4N-GPR34-VF0-Gi1/&β;1/&γ;2
5.56Single8T3VDHA8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.56Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
5.56Consensuscxcr_onOrthosteric Ligandcxcr1_on cxcr2_on
5.56Consensusm1_off_alloOther Ligand6WJC-M1-Atropine-Muscarinic toxin 7
5.26Single4QIMPubChem 249053754QIM-SMO-PubChem 24905375
5.26Single4Z9GCP-3763954Z9G-CRF1-CP-376395
5.26Single6C1RAvacopan; Na6C1R-C5a1-PMX53-Avacopan; Na
5.26Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
5.26Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
5.26Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
5.26Single8EJKTAK-8758EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
5.26Single8GTIBMK-C2058GTI-CRF1-BMK-C205
5.26Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
5.26Consensusc5a1_off_ortoalloOther Ligand6C1Q-C5a1-PMX53-NDT9513727 6C1R-C5a1-PMX53-Avacopan; Na
5.00Single4JKVTaladegib (LY2940680)4JKV-SMO-Taladegib (LY2940680)
5.00Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
5.00Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
5.00Single8GTGBMK-I1528GTG-CRF1-BMK-I152
4.76Single5V56TC1145V56-SMO-TC114
4.76Single5V57TC1145V57-SMO-TC114
4.76Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
4.76Single6OS1TRV0266OS1-AT1-TRV026
4.76Single7F1TMIP-1a7F1T-CCR5-MIP-1a
4.76Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
4.76Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
4.76Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
4.76Consensusmglu2_onOther Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
4.55Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
4.55Single4PY02MeSATP4PY0-P2Y12-2MeSATP
4.55Single6OS2TRV0266OS2-AT1-TRV026
4.55Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
4.55Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/&β;1/&γ;2
4.55Single8GTMBMK-C2038GTM-CRF1-BMK-C203
4.55Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
4.55Consensuschemokine_offOrthosteric Ligandcxcr_off
4.55Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II
4.55Consensuscxcr_offOrthosteric Ligandcxcr4_off
4.55Consensustsh_on_alloOther Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
4.35Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
4.35Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
4.17Single6KNMJN241-96KNM-Apelin-JN241-9
4.17Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.17Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
4.17Single8INRAlpha-MSH8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
4.17Single8SAI1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
4.17Consensusmotilin_onOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.00Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
4.00Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
3.85Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
3.85Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
3.70Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.70Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
3.57Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
3.33Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
3.23Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
3.12Consensuscalcitonin_onOrthosteric Ligandct_on ctlike_on
2.63Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
2.50Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/&β;1/&γ;2

Consensus Members
Id Members
7YFC 7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7YFD 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
Net Summary
Imin 3.46
Number of Linked Nodes 241
Number of Links 266
Number of Hubs 30
Number of Links mediated by Hubs 130
Number of Communities 7
Number of Nodes involved in Communities 44
Number of Links involved in Communities 59
Path Summary
Number Of Nodes in MetaPath 60
Number Of Links MetaPath 59
Number of Shortest Paths 30591
Length Of Smallest Path 3
Average Path Length 12.7404
Length of Longest Path 30
Minimum Path Strength 0.5975
Average Path Strength 6.46652
Maximum Path Strength 20.795
Minimum Path Correlation 0.7
Average Path Correlation 0.915719
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 4.16667
Average % Of Corr. Nodes 46.8126
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 41.2577
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following consensuses:
IdComponents
histamine_onh1_on
h4_on



You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download h4_on.zip



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