Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
1G.S1.02 4.79375465
2G.S1.07 4.28062429
3G.H1.01 4.34312409
4G.H1.04 3.14407
5G.S2.03 4.31625429
6G.S2.08 5.20754145
7G.S3.03 6.39062467
8G.S3.04 6.60187426
9G.S3.06 8.9715525
10G.s3h2.03 4.25812429
11G.H2.04 4.6605509
12G.H2.06 5.68969829
13G.H2.07 5.04333629
14G.h2s4.01 6.9625629
15G.S4.02 4.4225428
16G.S4.03 3.48812467
17G.S4.04 5.76208629
18G.H3.01 5.17937409
19G.H3.09 5.68375629
20G.H3.13 6.2585525
21G.H3.17 6.7365525
22G.H3.18 4.5175429
23G.S5.04 4.202529
24G.S5.05 4.55813869
25G.S5.07 3.0575409
26G.s5hg.01 4.610624199
27G.HG.07 4.515409
28G.hgh4.02 3.78375427
29G.hgh4.05 5.99813407
30G.H4.08 2.631503
31G.H4.10 5.78526
32G.H4.14 4.893525
33G.H4.15 6.26937428
34G.h4s6.02 5.11408
35G.h4s6.12 4.221254124
36G.S6.02 5.787086127
37G.S6.05 7.055404
38G.s6h5.01 3.1425469
39G.H5.05 4.514145
40G.H5.08 5.69255148
41G.H5.13 5.46855128
42G.H5.21 3.6525405
43b.h2x5 3.99375405
44b.lhb1x6 3.348134113
45b.b1x4 3.52875407
46b.l1x3 8.30855109
47b.l1x6 8.2085529
48b.b2x1 5.97062428
49b.b2x5 8.5825507
50b.l3x1 6.436529
51b.l3x2 5.34438409
52b.b4x5 4.37937447
53b.b4x6 9.430717109
54b.l4x2 12.7913474
55b.b5x2 4.68755187
56b.b5x3 7.063756109
57b.b5x5 5.245445
58b.b5x7 6.11125447
59b.l5x1 4.668548
60b.l5x5 6.6125729
61b.b6x3 2.77187408
62b.b6x5 4.595646
63b.b7x1 6.25955224
64b.b7x4 3.31917648
65b.b8x4 5.165646
66b.l8x1 3.57625445
67b.l8x3 3.946254233
68b.l8x5 3.911884233
69b.l8x8 4.9325444
70b.b9x3 3.88406
71b.l9x6 5.14429728
72b.b10x5 5.7905509
73b.l10x1 4.18687403
74b.b11x4 5.0954159
75b.l11x2 5.59313409
76b.b12x3 3.32438
77b.b12x5 3.86062436
78b.b12x6 10.41355158
79b.b13x7 8.2765537
80b.l13x3 7.885639
81b.l13x6 5.5375529
82b.l13x7 4.5155539
83b.b14x1 4.683528
84b.b14x3 4.37562435
85b.b15x1 6.213539
86b.b15x2 6.79375456
87b.b15x3 3.70625439
88b.l15x1 5.62875427
89b.l15x2 5.799539
90b.b16x4 9.119536
91b.b16x6 9.104538
92b.b17x7 8.2325458
93b.l17x3 9.681559
94b.l17x6 6.42958629
95b.b18x3 6.3375458
96b.b18x5 5.34505
97b.l18x1 8.14167686
98b.l18x2 6.92375487
99b.l18x3 7.19485
100b.b19x2 6.455656
101b.b19x4 6.0415558
102b.l19x2 7.71125409
103b.b20x2 5.84188456
104b.b20x4 9.182558
105b.b20x6 8.91688456
106b.b21x1 9.41375457
107b.b21x2 3.504506
108b.b21x7 5.54625605
109b.l21x2 5.35063404
110b.b22x5 5.29813887
111b.l22x5 5.596256119
112b.b23x6 6.74055137
113b.b24x2 5.055624135
114b.b24x4 6.785136
115b.b24x6 5.451254138
116b.l24x3 5.0365505
117b.l25x3 9.4225499
118b.l25x6 12.585428
119b.b26x3 3.2715506
120b.l26x5 4.468575
121b.b27x3 4.72187408
122b.l27x1 9.50719829
123b.l27x2 6.0495599
124b.b28x3 4.72155107
125b.b28x4 7.02187496
126b.b28x6 6.81833699
127g.h1x11 2.14687409
128g.h2x11 7.53188486
129g.ctx3 5.432926119
130g.ctx6 2.2735116
131g.ctx14 5.048579
132g.ctx16 5.58167678
133Lig 13.17462810
134NT 5.52937816
1351x24 3.37875414
1361x31 2.847504
1371x32 3.980624246
1381x50 3.448509
1392x39 4.308134208
1402x46 5.11375409
1412x50 6.01125409
1422x53 5.17375418
1432x56 9.06437416
1442x57 4.140624167
1452x60 6.02417
146E1x50 7.052519
1473x30 3.745406
1483x36 4.50312417
1493x50 6.57875409
1503x51 5.346508
151I2x50 5.9145508
152I2x52 3.0625405
1534x61 7.0725515
154E2 22.91051013
1555x32 3.89688414
1565x35 6.75875413
1575x36 3.94063414
1585x39 5.775417
1595x40 7.21937405
1605x42 5.86438414
1615x43 5.13688416
1625x46 5.37071715
1635x57 5.03813407
1645x58 6.08355259
1656x26 5.661256124
1666x29 4.36063405
1676x30 4.74563407
1686x44 4.78688419
1696x48 5.18937818
1706x52 6.69062418
1716x55 9.995416
1726x62 4.2925412
173E3 8.67562811
1747x23 5.0725615
1757x35 9.14562413
1767x54 2.6155507
1778x50 4.35255179
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1b.b3x6 b.l1x3 11.75978.02NoYes099
2b.b3x6 b.l3x2 11.85029.2025NoYes099
3b.l1x5 b.l3x2 12.84794.63NoYes079
4b.l1x5 b.l3x1 12.93974.9275NoYes079
5b.l3x1 b.l5x5 29.2847.1175YesYes299
6G.h2s4.01 b.l5x5 36.667810.27YesYes299
7G.S1.05 G.h2s4.01 36.581213.0925NoYes299
8G.S1.05 G.S1.07 36.49644.845NoYes299
9G.S1.07 G.S4.04 70.36655.1725YesYes299
10G.H3.09 G.S4.04 52.111111.79YesYes299
11G.H3.09 G.H4.15 51.56745.09YesYes298
12G.H4.15 G.S5.06 1003.655YesNo088
13G.S5.06 G.s4h3.01 99.43955.71NoNo087
14G.HG.04 G.s4h3.01 99.18117.59NoNo097
15G.HG.04 G.s4h3.04 98.22113.05NoNo098
16G.HG.07 G.s4h3.04 98.12658.955YesNo098
17G.HG.07 G.s4h3.02 97.46453.825YesNo099
18G.s4h3.02 G.s5hg.01 97.13453.06NoYes1999
19G.S5.07 G.s5hg.01 96.22593.4975YesYes099
20G.S5.07 G.s6h5.01 94.27974.02YesYes099
21G.S5.05 G.s6h5.01 86.04112.92YesYes699
22G.S4.03 G.S5.05 72.71283.455YesYes679
23G.S1.04 G.S4.03 72.3163.21NoYes677
24G.S1.04 G.S3.03 36.22543.9575NoYes677
25G.S1.02 G.S3.03 35.88516.9325YesYes657
26G.H5.15 G.S1.02 71.28162.525NoYes075
27G.H5.15 G.H5.19 71.04482.48NoNo078
283x53 G.H5.19 70.5713.52NoNo088
293x53 G.H5.23 70.3342.905NoNo084
303x50 G.H5.23 65.35784.845YesNo094
313x46 3x50 62.01885.7675NoYes099
32G.S4.04 G.S5.04 51.8833.3475YesYes299
33G.H4.15 G.S5.04 51.33417.0025YesYes289
34G.H5.11 G.S1.04 35.98433.4975NoNo687
35G.H5.11 G.S1.02 35.86993.99NoYes685
36G.H5.06 G.H5.10 16.11092.98NoNo036
37G.H5.10 G.S6.02 24.31245.36NoYes067
38G.H5.13 G.S6.02 13.143310.63YesYes1287
396x30 G.H5.13 10.87254.1675YesYes078
40b.b2x1 b.l27x1 16.94985.305YesYes289
41b.b26x1 b.l27x1 17.88194.94NoYes099
42b.b26x1 b.b26x2 17.72663.44NoNo097
43b.b26x2 b.b2x3 17.57364.455NoNo076
44G.H2.04 b.l17x6 64.81735.0625YesYes099
452x43 7x53 58.42972.855NoNo089
462x43 3x46 58.66933.9275NoNo089
477x53 8x50 57.20565.175NoYes1799
48b.b19x5 b.l21x9 12.29854.41NoNo056
49b.b19x4 b.b19x5 12.39552.73YesNo085
50b.b2x5 b.l4x1 12.24555.2525YesNo075
51b.b18x3 b.b19x4 17.34227.22YesYes588
52b.b15x2 b.b18x3 17.10415.7575YesYes568
53b.b15x2 b.b16x5 31.73993.725YesNo065
54b.b16x5 b.l14x6 46.72636.575NoNo053
55b.l14x5 b.l14x6 45.15053.34NoNo053
56b.l14x5 b.l16x2 44.52611.195NoNo059
57b.l16x1 b.l16x2 44.22874.2525NoNo049
58b.l10x1 b.l16x1 14.83162.98YesNo034
59b.b14x5 b.l10x1 13.57364.4975NoYes053
60b.b12x5 b.l16x1 29.09442.98YesNo064
61b.b14x5 b.b15x1 12.34482.74NoYes059
62b.b12x5 b.b13x5 18.97654.0525YesNo364
63b.b13x5 b.b13x7 18.7146.485NoYes347
64b.b15x1 b.b16x6 10.76188.27YesYes398
65b.b13x7 b.b16x6 10.783316.79YesYes378
66b.b19x2 b.b20x6 31.609311.79YesYes566
67b.b19x2 b.l20x1 15.90682.7425YesNo066
68b.l17x5 b.l17x6 64.12092.9425NoYes069
69b.l17x5 b.l19x2 64.02545.1525NoYes069
70b.b19x6 b.l19x2 26.92846.99NoYes099
71b.b19x6 b.l17x3 26.828511.855NoYes099
72b.b19x4 b.l17x3 26.46278.555YesYes589
73b.b20x2 b.l19x2 36.9078.31YesYes069
74b.b20x2 b.b20x4 36.60767.1125YesYes568
751x53 8x50 55.30373.65NoYes099
761x53 2x47 54.58252.7575NoNo099
771x50 2x47 54.10152.7375YesNo099
781x50 2x50 52.17535.05YesYes099
792x46 2x50 49.03795.09YesYes099
802x46 3x43 44.4364.1525YesNo098
813x43 6x44 44.19333.0425NoYes089
826x44 6x48 40.74075.51YesYes198
836x48 Lig 30.18144.2175YesYes180
84G.H2.04 G.H3.08 33.6736.865YesNo099
85b.b2x5 b.b3x2 11.03318.79YesNo075
86b.l4x1 g.ctx16 10.76783.96NoYes758
87b.b20x4 b.b20x6 36.33054.545YesYes586
88b.b15x2 b.b19x2 15.88999.175YesYes566
89b.b16x5 b.l20x1 15.29838.995NoNo056
90G.H2.04 G.S1.07 33.74164.25YesYes099
91G.H3.08 G.S4.04 33.66366.92NoYes099
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
6x55Lig18.8351YesYes6010
6x58Lig7.48751NoYes4010
5x36Lig6.92251YesYes4010
E2Lig55.40751YesYes3010
E3Lig8.99751YesYes1010
6x62Lig4.2551YesYes2010
7x23Lig4.36751YesYes5010
LigNT4.051YesYes0601
7x27Lig9.26751NoYes3010
1x25Lig4.45751NoYes4010
7x31Lig10.3551NoYes3010
7x34Lig15.321NoYes4010
E2x51Lig5.95251NoYes4010
E1Lig4.25250NoYes4010
2x60Lig8.14251YesYes7010
6x51Lig10.681NoYes6010
7x35Lig4.2051YesYes3010
7x38Lig4.41751NoYes6010
2x59Lig3.67751NoYes6010
2x63Lig2.9051NoYes5010
E1x50Lig3.52251YesYes9010
3x32Lig6.98751NoYes6010
3x33Lig9.281NoYes4010
5x43Lig5.411YesYes6010
6x48Lig4.21751YesYes8010
NTNT5.2851YesYes6611
E3NT2.8951YesYes1611
7x23NT5.921YesYes5611
7x24NT3.640NoYes8621
1x22E32.9051NoYes4121
1x277x313.21250NoNo5321
1x357x3511.3351NoYes5321
2x532x569.38251YesYes8622
2x533x363.33751YesYes8722
2x536x484.96251YesYes8821
2x562x606.73251YesYes6721
2x563x3216.64251YesNo6621
2x592x602.8351NoYes6711
2x607x386.371YesNo7611
2x63E1x506.091NoYes5911
2x647x3518.46250NoYes4321
E1x49E1x514.42751NoNo5222
E1x49E23.31751NoYes5321
E1x50E1x515.4051YesNo9212
3x25E1x505.87751NoYes9921
E1x50E2x5014.3651YesNo9912
3x25E2x506.371NoNo9922
3x323x333.731NoNo6411
3x334x6112.151NoYes4512
3x366x485.211YesYes7821
4x615x395.41YesYes5722
E2E269.011YesYes3311
E2E2x516.57751YesNo3411
5x36E2x522.71YesNo4512
5x36E23.711YesYes4311
5x32E26.371YesYes4321
5x395x403.45751YesYes7522
5x395x435.28751YesYes7621
5x406x558.040YesYes5621
5x425x433.991YesYes4621
5x425x469.521YesYes4522
6x446x485.511YesYes9821
6x447x458.461YesNo9922
6x486x515.12251YesNo8611
6x486x523.17751YesYes8812
6x487x419.07751YesNo8812
6x487x454.23751YesNo8912
6x547x349.570NoNo5421
6x556x588.04251YesNo6411
6x557x345.06251YesNo6411
6x627x234.1151YesYes2511
6x627x273.51751YesNo2311
E3E318.87251YesYes1111
1x24NT4.4151YesYes4611
2x567x383.51YesNo6621
6x62E35.28251YesYes2111
7x23E37.80251YesYes5111
7x26E33.77751NoYes2121
1x24Lig2.821YesYes4010
E2NT12.7451YesYes3611
1x227x236.4851NoYes4521
1x241x254.251YesNo4411
1x267x272.820NoNo5321
3x365x466.311YesYes7522
5x435x465.861YesYes6512
5x466x524.3551YesYes5822
1x317x352.580YesYes4321
5x365x372.431YesNo4412
1x231x242.030NoYes4421
7x237x251.7451YesNo5412
3x22E21.56250NoYes3321
5x33E21.3951NoYes1321

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
92.31Consensusendothelin_onOrthosteric Ligandetb_on eta_on
85.19Single8IY6Endothelin-18IY6-ETB-Endothelin-1
82.14Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
79.31Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
78.57Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
78.57Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
74.07Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
72.41Single6IGLIRL16206IGL-ETB-IRL1620
70.97Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
70.00Single5GLHEndothelin-15GLH-ETB-Endothelin-1
70.00Single6IGKEndothelin-36IGK-ETB-Endothelin-3
67.86Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
67.86Single8ZRTET-18ZRT-ETB-ET-1
67.86Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
67.86Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
67.74Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
63.33Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
60.00Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
60.00Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
58.06Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
58.06Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
56.67Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
56.67Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
54.84Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
53.33Single6JODAngiotensin II6JOD-AT2-Angiotensin II
53.33Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
53.33Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
53.12Single9KDFRES-701-39KDF-ETB-RES-701-3
51.72Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
51.72Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
51.72Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
51.61Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
51.61Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
51.52Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
51.52Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
51.52Consensusbradykinin_onOrthosteric Ligandbk2_on
51.52Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
51.52Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
50.00Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
50.00Consensusangiotensin_onOrthosteric Ligandat1_on
50.00Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
50.00Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
50.00Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
50.00Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
50.00Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
50.00Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
50.00Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
50.00Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
48.57Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
48.48Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
48.39Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
48.39Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
48.39Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
48.39Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
48.39Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
48.39Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
48.39Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
48.39Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
48.39Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
48.28Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
48.15Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
48.15Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
46.88Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
46.88Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
46.67Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
46.67Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
46.43Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
46.43Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
45.45Single7SK3CXCL127SK3-ACKR3-CXCL12
45.16Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
44.83Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
44.44Single6OS1TRV0266OS1-AT1-TRV026
44.12Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
44.12Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
44.12Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
43.33Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
43.33Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
43.33Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
42.86Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
42.86Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
42.86Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
42.86Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
42.86Consensuslpa_offOrthosteric Ligandlpa1_off
42.86Consensuslpl_offOrthosteric Ligands1p_off lpa_off
42.42Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
42.42Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
42.42Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
42.42Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
42.42Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
42.11Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
41.94Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
41.94Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
41.94Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
41.94Single9KFIRelaxin-39KFI-RXFP3-Relaxin-3-Gi2/β1/γ2
41.94Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
41.67Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
41.67Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
41.67Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
41.38Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
41.38Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
41.38Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
41.38Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
41.38Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
41.18Single4XT3Fractalkine4XT3-US28-Fractalkine
41.18Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
41.18Single9KFKRelaxin-39KFK-RXFP4-Relaxin-3-Gi2/β1/γ2
41.18Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
41.18Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
41.18Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
41.18Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
41.18Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
40.74Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
40.74Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
40.62Single3OE0CVX153OE0-CXCR4-CVX15
40.62Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
40.62Single6PT2KGCHM076PT2-δ-KGCHM07
40.62Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
40.62Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
40.62Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
40.62Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
40.62Single9U4WGonadoliberin-19U4W-GnRH1-Gonadoliberin-1-chim(NtGi1L-Gs-CtGq)/β1/γ2
40.62Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
40.62Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
40.62Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
40.62Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
40.62Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
40.62Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
40.00Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
40.00Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
40.00Single8QJ2pN1628QJ2-MC4-pN162-Gs
40.00Single8XQJJN2418XQJ-Apelin-JN241
40.00Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
40.00Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
40.00Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
40.00Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
40.00Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
40.00Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
40.00Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
40.00Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
39.39Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
39.39Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
39.39Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
39.39Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
39.39Single8ZBISomatostatin-148ZBI-SST3-Somatostatin-14-Gi1/β1/γ2
39.39Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
39.39Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
39.39Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
39.29Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
39.29Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
39.29Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
39.29Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
39.29Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
38.71Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
38.71Single8WDTphotoNECA8WDT-A2A-photoNECA
38.71Single8XWNCXCL88XWN-CXCR2-CXCL8
38.71Single8ZBJSomatostatin-148ZBJ-SST5-Somatostatin-14-Gi1/β1/γ2
38.71Single9BUYLM1899BUY-β2-LM189-Gi1/β1/γ2
38.71Single9HB3Mambaquaretin-19HB3-V2-Mambaquaretin-1
38.71Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
38.71Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
38.71Consensuslpl_onOrthosteric Ligands1p_on lpa_on
38.71Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
38.71Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
38.71Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
38.46Single7T94LY21196207T94-M2-Acetylcholine-LY2119620-chim(NtGi1-Go)/β1/γ2
38.24Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
38.24Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
38.24Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
38.24Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
38.24Single9JFYhNPSF9JFY-NPFF2-hNPSF-Gi1/β1/γ2
38.24Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
38.24Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
38.24Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
37.93Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
37.93Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
37.93Single6OS2TRV0266OS2-AT1-TRV026
37.93Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
37.93Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
37.93Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
37.93Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
37.93Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
37.93Consensusorexin_onOrthosteric Ligandox2_on
37.50Single3QAKUK-4320973QAK-A2A-UK-432097
37.50Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
37.50Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
37.50Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
37.50Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
37.50Single9IQRMuscarinic toxin 39IQR-α2a-Muscarinic toxin 3
37.50Single9IQSMuscarinic toxin 39IQS-M4-Muscarinic toxin 3
37.50Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
37.50Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
37.50Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
37.14Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
37.14Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
37.04Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
37.04Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
37.04Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
37.04Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
36.84Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
36.84Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
36.67Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
36.67Single7EZCUKA7EZC-A2A-UKA
36.67Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
36.67Single8XVUCXCL28XVU-CXCR2-CXCL2
36.67Single8XWFCXCL38XWF-CXCR2-CXCL3
36.67Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
36.67Single8ZPLHF511168ZPL-CXCR4-HF51116
36.67Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
36.59Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
36.59Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
36.36Single5WF5UK-4320975WF5-A2A-UK-432097
36.36Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
36.36Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
36.36Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
36.36Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
36.36Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
36.36Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
36.36Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
36.11Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
36.11Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
36.11Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
36.11Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
36.11Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
36.11Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
35.90Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
35.71Single5N2RPSB-365N2R-A2A-PSB-36-Na
35.71Single5N2SPSB365N2S-A1-PSB36
35.71Single6D26Fevipiprant6D26-DP2-Fevipiprant
35.71Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
35.71Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
35.71Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
35.71Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
35.71Consensusdp_offOrthosteric Liganddp2_off
35.48Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
35.48Single5WF6UK-4320975WF6-A2A-UK-432097
35.48Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
35.48Single6KNMJN241-96KNM-Apelin-JN241-9
35.48Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
35.48Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
35.48Single7XN9L-054,5227XN9-SST2-L-054,522
35.48Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
35.48Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
35.48Single8Y72Peptide8Y72-μ-Peptide-BMS-986122-Gi1/β1/γ2
35.48Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
35.48Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
35.29Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
35.29Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
35.29Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
35.29Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
35.29Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
35.29Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
35.29Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
35.29Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
35.29Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
35.29Consensusvasop-oxy_onOrthosteric Ligandv2_on
35.29Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
35.14Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
34.62Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
34.62Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
34.48Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
34.48Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
34.48Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
34.48Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
34.48Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
34.48Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
34.48Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
34.48Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
34.48Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
34.48Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
34.48Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
34.48Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
34.48Consensuslpa_onOrthosteric Ligandlpa1_on
34.48Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
34.48Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
34.38Single4IARErgotamine4IAR-5-HT1B-Ergotamine
34.38Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
34.38Single4XT1Fractalkine4XT1-US28-Fractalkine
34.38Single7F8XNN90567F8X-CCKA-NN9056
34.38Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
34.38Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
34.38Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
34.38Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
34.38Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
34.38Single8U4OCXCL128U4O-CXCR4-CXCL12-Gi1/β1/γ2
34.38Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
34.38Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
34.38Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
34.38Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
34.38Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
34.38Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
34.38Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
34.38Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
34.38Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
34.38Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
34.38Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
34.29Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
34.29Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
34.29Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
34.29Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
34.29Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
34.21Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
34.21Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
34.21Consensusbombesin_onOrthosteric Ligandbb2_on
34.21Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
34.21Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
33.33Single6MXTSalmeterol6MXT-β2-Salmeterol
33.33Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
33.33Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
33.33Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
33.33Single7F61PF-036547467F61-H3-PF-03654746
33.33Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
33.33Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
33.33Single7SK5CXCL127SK5-ACKR3-CXCL12
33.33Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
33.33Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
33.33Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
33.33Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
33.33Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
33.33Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
33.33Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single8JJLOlodaterol8JJL-β2-Olodaterol
33.33Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
33.33Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
33.33Single8XQJJN2418XQJ-Apelin-JN241
33.33Single8XWACXCL18XWA-CXCR2-CXCL1
33.33Single8XWMCXCL68XWM-CXCR2-CXCL6
33.33Single8XWSCXCL58XWS-CXCR2-CXCL5
33.33Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
33.33Single9E82SDF-1-beta9E82-ACKR3-SDF-1-β-Arrestin2
33.33Single9IK8SST analogue9IK8-SST1-SST analogue-Gi1/β1/γ2
33.33Single9IQVMuscarinic toxin 39IQV-Alpha1A-Muscarinic toxin 3
33.33Single9J0FNADH9J0F-P2Y14-NADH-Gi1/β1/γ2
33.33Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
33.33Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
33.33Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
33.33Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
33.33Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
33.33Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
33.33Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
33.33Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
33.33Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
33.33Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
33.33Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
33.33Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
33.33Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
33.33Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
33.33Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
33.33Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
33.33Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
33.33Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
32.43Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
32.35Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
32.35Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
32.35Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
32.35Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
32.35Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
32.35Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
32.35Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
32.35Single9M1OMorphine-Modulating Neuropeptide B9M1O-NPFF2-Morphine-Modulating Neuropeptide B-Gi1/β1/γ2
32.35Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
32.35Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
32.35Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
32.35Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
32.26Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
32.26Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
32.26Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
32.26Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
32.26Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
32.26Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
32.26Single8ZWGJR14a8ZWG-C3aB-JR14a-Gi1/β1/γ2
32.26Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
32.26Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
32.26Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
32.26Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
32.26Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
32.26Consensusprostanoid_offOrthosteric Ligandep_off dp_off
32.14Single6D27CAY104716D27-DP2-CAY10471
32.14Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
32.14Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
32.14Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
31.91Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
31.58Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
31.58Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
31.58Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
31.43Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
31.43Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
31.43Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
31.43Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
31.43Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
31.43Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
31.43Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
31.25Single4UG2CGS216804UG2-A2A-CGS21680
31.25Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
31.25Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
31.25Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
31.25Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
31.25Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
31.25Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
31.25Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
31.25Single8X5YAstemizole8X5Y-H1-Astemizole
31.25Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
31.25Single9IPVJR14a9IPV-C3aB-JR14a-Gi1/β1/γ2
31.25Single9V2NMacimorelin9V2N-Ghrelin-Macimorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
31.25Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
31.25Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
31.25Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
31.25Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
31.25Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
31.03Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
31.03Single5C1MBU725C1M-μ-BU72
31.03Single5IUAQ274563485IUA-A2A-Q27456348-Na
31.03Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
31.03Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
31.03Single6S0QZM-2413856S0Q-A2A-ZM-241385
31.03Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
31.03Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
31.03Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
31.03Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
31.03Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
31.03Single8GNEKW-63568GNE-A2A-KW-6356-Na
31.03Single8QOTNanobody-E8QOT-μ-Nanobody-E
31.03Single8S4DCMF-0198S4D-Apelin-CMF-019
31.03Single8TF5Oleic acid8TF5-GPR6-Oleic acid
31.03Single8ZYTNeurotensin peptide 8-138ZYT-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
31.03Single9EHSLUF76029EHS-A3A-LUF7602
31.03Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
31.03Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
31.03Consensusadenosine_offOrthosteric Liganda1_off a2_off
31.03Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
31.03Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
30.77Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
30.77Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
30.77Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
30.56Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
30.56Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
30.56Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
30.56Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
30.30Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
30.30Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
30.30Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
30.30Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
30.30Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
30.30Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
30.30Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
30.30Single9J0IUDP-Glucuronic acid9J0I-P2Y14-UDP-Glucuronic acid-Gi1/β1/γ2
30.30Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
30.30Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
30.00Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
30.00Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
30.00Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
30.00Single7F1TMIP-1a7F1T-CCR5-MIP-1a
30.00Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
30.00Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
30.00Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
30.00Single7PX4PSB-21137PX4-A2A-PSB-2113
30.00Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
30.00Single7TUYGSK682753A7TUY-GPR183-GSK682753A
30.00Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
30.00Single8E0GBU728E0G-μ-BU72
30.00Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
30.00Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
30.00Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
30.00Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
30.00Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
30.00Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
30.00Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
30.00Single8XVLZibotentan8XVL-ETA-Zibotentan
30.00Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
30.00Single8ZWFJR14a8ZWF-C3aB-JR14a
30.00Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
30.00Single9IK9SST analogue9IK9-SST1-SST analogue-Gi1/β1/γ2
30.00Consensusneurotensin_onOrthosteric Ligandnts1_on
30.00Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
30.00Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
29.73Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
29.73Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
29.63Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
29.63Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
29.63Single8GNGIstradefylline8GNG-A2A-Istradefylline
29.63Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
29.63Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
29.63Single8U4PAMD31008U4P-CXCR4-AMD3100-Gi1/β1/γ2
29.63Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
29.63Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
29.41Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
29.41Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
29.41Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
29.41Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
29.41Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
29.41Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
29.03Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
29.03Single4RWADIPP-NH24RWA-δ-DIPP-NH2
29.03Single4XEENeurotensin4XEE-NTS1-Neurotensin
29.03Single4XESNeurotensin4XES-NTS1-Neurotensin
29.03Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
29.03Single6A93Risperidone6A93-5-HT2A-Risperidone
29.03Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
29.03Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
29.03Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
29.03Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
29.03Single7YITNalfurafine7YIT-κ-Nalfurafine
29.03Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
29.03Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
29.03Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
29.03Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
29.03Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
29.03Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
29.03Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
29.03Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
29.03Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
29.03Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
29.03Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
29.03Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
28.95Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
28.95Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
28.95Single8W8XBeta-MSH8W8X-MC3-β-MSH-Ca-Gs/β1/γ2
28.57Single4MBSMaraviroc4MBS-CCR5-Maraviroc
28.57Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
28.57Single6MH8ZM-2413856MH8-A2A-ZM-241385
28.57Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
28.57Single7AROLUF58337ARO-A2A-LUF5833-Na
28.57Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
28.57Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
28.57Single7T32ZM-2413857T32-A2A-ZM-241385
28.57Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
28.57Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
28.57Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
28.57Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
28.57Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
28.57Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
28.57Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
28.57Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
28.57Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
28.57Single8ZPMAMD0708ZPM-CXCR4-AMD070
28.57Single8ZPNAMD31008ZPN-CXCR4-AMD3100
28.57Single9JH3CMF-0199JH3-Apelin-CMF-019-Gi1/β1/γ2
28.57Single9JMDAzithromycin9JMD-Motilin-Azithromycin-chim(Gs-CtGq)/β1/γ2
28.57Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
28.57Consensusclass-a_class-b1_cons_on_gpOrthosteric Ligandclass-a_on_gp class-b1_on_gp
28.57Consensusgrh_offOrthosteric Ligandgnrh1_off
28.12Single4BUONeurotensin4BUO-NTS1-Neurotensin
28.12Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
28.12Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
28.12Single6IBLArformoterol6IBL-β1-Arformoterol
28.12Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
28.12Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
28.12Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
28.12Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
28.12Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
28.12Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-SBI-553-chim(NtGi1-Go)/β1/γ2
28.12Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
28.12Single8JPFNeurotensin8JPF-NTS1-Neurotensin-SBI-553
28.12Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
28.12Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
28.12Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
28.12Single9M54Neuropeptide VF9M54-NPFF2-Neuropeptide VF-Gi1/β1/γ2
28.12Consensuscck_onOrthosteric Ligandccka_on cckb_on
28.12Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
28.12Consensuschemerin_onOrthosteric Ligandcml1_on
28.12Consensusendothelin_offOrthosteric Ligandetb_off
28.12Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
28.12Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
28.12Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
28.12Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
27.78Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
27.59Single3EMLZM-2413853EML-A2A-ZM-241385
27.59Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
27.59Single4EJ4Naltrindole4EJ4-δ-Naltrindole
27.59Single4QIMANTA XV4QIM-SMO-ANTA XV
27.59Single5IU8Q274563475IU8-A2A-Q27456347-Na
27.59Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
27.59Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
27.59Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
27.59Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
27.59Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
27.59Single6S0LZM-2413856S0L-A2A-ZM-241385
27.59Single6XBM5LWE6XBM-SMO-5LWE-Gi1/β1/γ2
27.59Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
27.59Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
27.59Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
27.59Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
27.59Single7PYRPSB-21157PYR-A2A-PSB-2115
27.59Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
27.59Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
27.59Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
27.59Single8CU6LJ-45178CU6-A2A-LJ-4517
27.59Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
27.59Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
27.59Single8TH3AT118-H Nanobody8TH3-AT1-AT118-H Nanobody
27.59Single9CHXS-Carazolol9CHX-β2-S-Carazolol
27.59Single9H37A1IR09H37-A2A-A1IR0-Na
27.59Single9KFJPubChem 1383196749KFJ-RXFP3-PubChem 138319674-Gi2/β1/γ2
27.59Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
27.59Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
27.59Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
27.59Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
27.59Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
27.50Consensusclass-a_class-b1_cons_onOrthosteric Ligandclass-a_on class-b1_on
27.27Single3NY9ICI118-5513NY9-β2-ICI118-551
27.27Single5ZTYAM102575ZTY-CB2-AM10257
27.27Single6PT3DPI-2876PT3-δ-DPI-287
27.27Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
27.27Single7SK9CCX6627SK9-ACKR3-CCX662
27.27Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
27.27Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
27.27Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
27.27Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
27.27Single9CGKC5-Quino9CGK-δ-C5-Quino-Gi1/β1/γ2
27.27Single9IPYJR14a9IPY-C3aB-JR14a
27.27Single9M0RNeuropeptide VF9M0R-NPFF1-Neuropeptide VF-Gi1/β1/γ2
27.27Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
27.27Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
27.03Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
27.03Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
27.03Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
27.03Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
26.92Single4XNWMRS25004XNW-P2Y1-MRS2500
26.92Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/β1/γ2
26.92Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
26.67Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
26.67Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
26.67Single7C61Ergotamine7C61-5-HT1B-Ergotamine
26.67Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
26.67Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
26.67Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
26.67Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
26.67Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
26.67Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
26.67Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
26.67Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
26.67Single9F34FOB02-04A9F34-D3-FOB02-04A-Go/β1/γ2
26.67Single9I52A1IZU9I52-D1-A1IZU-Gs/β1/γ2
26.67Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
26.67Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
26.47Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
26.47Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
26.47Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
26.47Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
26.47Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
26.47Single8PKMBefiradol8PKM-5-HT1A-Befiradol-Gi1/β1/γ1
26.47Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
26.47Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
26.47Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
26.47Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
26.47Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
26.47Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
26.47Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
26.32Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
26.32Consensuspac_on_gpOrthosteric Ligandpac1_on_gp
26.19Consensuscrf_on_gpOrthosteric Ligandcrf2_on_gp crf1_on_gp
25.93Single4O9RCyclopamine4O9R-SMO-Cyclopamine
25.93Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
25.81Single2YDVNECA2YDV-A2A-NECA
25.81Single3P0GBI1671073P0G-β2-BI167107
25.81Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
25.81Single4BV0Neurotensin4BV0-NTS1-Neurotensin
25.81Single4UHRCGS216804UHR-A2A-CGS21680
25.81Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
25.81Single5G53NECA5G53-A2A-NECA-Gs
25.81Single5V56TC1145V56-SMO-TC114
25.81Single6J21Aprepitant6J21-NK1-Aprepitant
25.81Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
25.81Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
25.81Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
25.81Single7FEECP559407FEE-CB1-CP55940-ZCZ011
25.81Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
25.81Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
25.81Single7R0CAVP7R0C-V2-AVP-Arrestin2
25.81Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
25.81Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
25.81Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
25.81Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
25.81Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
25.81Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.81Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
25.81Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
25.81Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.81Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
25.81Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
25.81Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
25.81Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
25.81Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
25.81Single8Y73Peptide8Y73-μ-Peptide-MPAM-15-Gi1/β1/γ2
25.81Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
25.81Single9BJKNaloxone9BJK-μ-Naloxone-NAM
25.81Single9JMCDS-3801b9JMC-Motilin-DS-3801b-chim(Gs-CtGq)/β1/γ2
25.81Single9UY3Anamorelin9UY3-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
25.81Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
25.81Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
25.81Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
25.81Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
25.81Consensusrelaxin_onOrthosteric Ligandrxfp4_on
25.81Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
25.81Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
25.81Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
25.71Single6HLOAprepitant6HLO-NK1-Aprepitant
25.71Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
25.71Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
25.71Single7XNACYN1548067XNA-SST2-CYN154806
25.71Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
25.71Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
25.71Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
25.71Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
25.71Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
25.71Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
25.64Single8W8WAlpha-MSH8W8W-MC3-α-MSH-Ca-Gs/β1/γ2
25.00Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
25.00Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
25.00Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
25.00Single4AMIBucindolol4AMI-β1-Bucindolol
25.00Single4BWBNeurotensin4BWB-NTS1-Neurotensin
25.00Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
25.00Single4QINSAG1.54QIN-SMO-SAG1.5
25.00Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
25.00Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
25.00Single6AKXA4R6AKX-CCR5-A4R
25.00Single6AKYMaraviroc6AKY-CCR5-Maraviroc
25.00Single6CM4Risperidone6CM4-D2-Risperidone
25.00Single6DS0Ly2660976DS0-5-HT2B-Ly266097
25.00Single6KQICP559406KQI-CB1-CP55940-Org27569
25.00Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
25.00Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
25.00Single6YVRNTS8-136YVR-NTS1-NTS8-13
25.00Single6ZG4HTL00099366ZG4-M1-HTL0009936
25.00Single7BR3Elagolix7BR3-GnRH1-Elagolix
25.00Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
25.00Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
25.00Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
25.00Single7F8ULintitript7F8U-CCKA-Lintitript
25.00Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
25.00Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
25.00Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
25.00Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
25.00Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
25.00Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
25.00Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
25.00Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
25.00Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
25.00Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
25.00Single7XRRLemborexant7XRR-OX2-Lemborexant
25.00Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
25.00Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
25.00Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
25.00Single8JJ8Formoterol8JJ8-β2-Formoterol
25.00Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
25.00Single8JWY2-1188JWY-A2A-2-118
25.00Single8JWZAB9288JWZ-A2A-AB928-Na
25.00Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
25.00Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
25.00Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
25.00Single8YYWAlpha-ketoglutarate8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
25.00Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
25.00Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
25.00Single9M4QDoxazosin9M4Q-Alpha1A-Doxazosin
25.00Consensusalpha1_offOrthosteric Ligandalpha1a_off
25.00Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
25.00Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
25.00Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
25.00Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
25.00Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
25.00Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
25.00Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
25.00Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
25.00Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
25.00Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
25.00Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
25.00Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
25.00Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
25.00Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
25.00Consensusvip-pacap_onOrthosteric Ligandvpac_on pac_on
25.00Consensusvip-pacap_on_gpOrthosteric Ligandvpac_on_gp pac_on_gp
24.32Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
24.32Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
24.32Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
24.32Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
24.24Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
24.24Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
24.24Single5X93K-87945X93-ETB-K-8794
24.24Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
24.24Single6H7LDobutamine6H7L-β1-Dobutamine
24.24Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
24.24Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
24.24Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
24.24Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
24.24Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
24.24Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
24.24Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
24.24Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
24.24Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
24.24Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
24.24Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
24.24Single8T3OTUG-8918T3O-FFA4-TUG-891-chim(NtGi2L-Gs-CtGq)/β1/γ2
24.24Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
24.24Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
24.24Single9CGJC6-Quino9CGJ-δ-C6-Quino-Gi1/β1/γ2
24.24Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
24.24Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
24.24Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
24.24Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
24.24Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
24.24Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
24.24Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
24.24Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
24.24Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
24.14Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
24.14Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
24.14Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
24.14Single5IU7Q274563465IU7-A2A-Q27456346-Na
24.14Single5IUBQ274563445IUB-A2A-Q27456344-Na
24.14Single5JTBZM-2413855JTB-A2A-ZM-241385
24.14Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
24.14Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
24.14Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
24.14Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
24.14Single5UVIZM-2413855UVI-A2A-ZM-241385
24.14Single6AQFZM-2413856AQF-A2A-ZM-241385
24.14Single6IQLL7458706IQL-D4-L745870
24.14Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
24.14Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
24.14Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
24.14Single7UTZDPPC7UTZ-TSH-TR1402-DPPC-Gs/β1/γ2
24.14Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
24.14Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
24.14Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
24.14Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
24.14Single8RLNLUF58348RLN-A2A-LUF5834
24.14Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
24.14Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
24.14Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
24.14Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
24.14Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
24.14Single8Y6YGLPG09748Y6Y-FFA2-GLPG0974
24.14Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
24.14Single9JFUNE52-QQ579JFU-GPR4-NE52-QQ57
24.14Single9K0KUTP9K0K-P2Y4-UTP-chim(NtGi1-Gs-CtGq)/β1/γ2
24.14Single9K0XATP9K0X-P2Y2-ATP-chim(NtGi1-Gs-CtGq)/β1/γ2
24.14Single9K20ATP9K20-P2Y2-ATP-chim(NtGi1-Go)/β1/γ2
24.14Single9M2FNeuropeptide FF9M2F-NPFF1-Neuropeptide FF-Gi1/β1/γ2
24.14Consensusa2_offOrthosteric Liganda2a_off
24.14Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
24.14Consensusalpha1_onOrthosteric Ligandalpha1a_on
24.14Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
24.14Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
24.14Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
24.14Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
24.14Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
23.68Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
23.68Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
23.68Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
23.68Consensuspac_onOrthosteric Ligandpac1_on
23.53Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
23.53Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
23.53Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
23.53Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
23.53Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
23.53Single9IZASCH9002719IZA-HCA2-SCH900271-Gi1/β1/γ2
23.53Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
23.53Consensuskisspeptin_onOrthosteric Ligandkiss1_on
23.33Single2Y02Carmoterol2Y02-β1-Carmoterol
23.33Single3NY8ICI118-5513NY8-β2-ICI118-551
23.33Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
23.33Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
23.33Single4GBRS-Carazolol4GBR-β2-S-Carazolol
23.33Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
23.33Single5DHHSB-6121115DHH-NOP-SB-612111
23.33Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
23.33Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
23.33Single5UENDU1725UEN-A1-DU172
23.33Single5UIGCmpd-15UIG-A2A-Cmpd-1
23.33Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
23.33Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
23.33Single6TOTLemborexant6TOT-OX1-Lemborexant
23.33Single7BU7BI1671077BU7-β1-BI167107
23.33Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
23.33Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
23.33Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
23.33Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
23.33Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
23.33Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
23.33Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
23.33Single7UL4Alvimopan7UL4-μ-Alvimopan
23.33Single7V3ZCP559407V3Z-CB1-CP55940
23.33Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
23.33Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
23.33Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
23.33Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
23.33Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
23.33Single8JXRLSD8JXR-D1-LSD
23.33Single8T1WCVN4248T1W-GPR6-CVN424
23.33Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.33Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.33Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.33Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
23.33Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
23.33Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
23.33Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
23.33Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
23.33Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
23.33Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
23.33Single8ZYYNeurotensin peptide 8-138ZYY-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
23.33Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
23.33Single9PLNN-(5-methylnaphthalen-1-yl)pyridin-4-amine9PLN-α2a-N-(5-methylnaphthalen-1-yl)pyridin-4-amine
23.33Single9PLON-(5-methylnaphthalen-1-yl)pyridin-4-amine9PLO-α2a-N-(5-methylnaphthalen-1-yl)pyridin-4-amine-Go/β1/γ2
23.33Consensusa3_onOrthosteric Liganda3a_on
23.33Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
23.33Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
23.33Consensuscck_offOrthosteric Ligandccka_off
23.33Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
23.33Consensusdopamine_offOrthosteric Ligandd2_off d3_off
23.33Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
23.33Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
23.08Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
23.08Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
23.08Single9BLWCagrilintide backbone (non-acylated)9BLW-CT (AMY1)-Cagrilintide backbone (non-acylated)-Gs/β1/γ2; RAMP1
23.08Consensusp2y_offOrthosteric Ligandp2y1_off
22.86Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
22.86Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
22.86Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
22.86Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
22.86Single8WKYPG-9348WKY-MC4-PG-934
22.86Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
22.86Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
22.86Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
22.86Consensussomatostatin_offOrthosteric Ligandsst2_off
22.58Single2RH1S-Carazolol2RH1-β2-S-Carazolol
22.58Single2Y00Dobutamine2Y00-β1-Dobutamine
22.58Single2YCWS-Carazolol2YCW-β1-S-Carazolol
22.58Single4JKVTaladegib4JKV-SMO-Taladegib
22.58Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
22.58Single5D6LS-Carazolol5D6L-β2-S-Carazolol
22.58Single5X7DS-Carazolol5X7D-β2-S-Carazolol-Cmpd-15
22.58Single5XPRBosentan5XPR-ETB-Bosentan
22.58Single6E67BI1671076E67-β2-BI167107-Gs(CT)
22.58Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
22.58Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
22.58Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
22.58Single7C4SS1P7C4S-S1P3-S1P
22.58Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
22.58Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
22.58Single7LD3Adenosine7LD3-A1-Adenosine-MIPS521-Gi2/β1/γ2
22.58Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
22.58Single7W41PD1762527W41-BB2-PD176252
22.58Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
22.58Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
22.58Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
22.58Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
22.58Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
22.58Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
22.58Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
22.58Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
22.58Single8JXSPF-61428JXS-D1-PF-6142
22.58Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
22.58Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
22.58Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
22.58Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
22.58Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
22.58Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
22.58Single9CIBFCH-22964139CIB-HCA2-FCH-2296413
22.58Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
22.58Single9EE8Adenosine9EE8-A2A-Adenosine-Gs/β1/γ2
22.58Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
22.58Single9K07DSO-5a9K07-BB3-DSO-5a-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.58Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
22.58Consensusa3_on_gpOrthosteric Liganda3a_on_gp
22.58Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
22.58Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
22.58Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
22.58Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
22.58Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
22.58Consensusamine_offonOrthosteric Ligandamine_off amine_on
22.58Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
22.58Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
22.58Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
22.58Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
22.58Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
22.58Consensusbombesin_offOrthosteric Ligandbb2_off
22.58Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
22.58Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
22.58Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
22.58Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
22.58Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
22.58Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
22.58Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
22.58Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
22.58Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
22.58Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
22.58Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
22.58Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
22.58Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
22.58Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
22.58Consensustrace-amine_onOrthosteric Ligandta1_on
22.50Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
22.50Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
22.50Consensusglp_onOrthosteric Ligandglp1_on glp2_on
22.50Consensusglp_on_gpOrthosteric Ligandglp1_on_gp glp2_on_gp
22.22Single3OE6IT1t3OE6-CXCR4-IT1t
22.22Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
22.22Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
22.22Single7WC5Psilocin7WC5-5-HT2A-Psilocin
22.22Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
22.22Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
22.22Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
22.22Consensuspth_onOrthosteric Ligandpth1_on pth2_on
21.95Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
21.95Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
21.95Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
21.95Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
21.95Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
21.95Single9BYOExendin-39BYO-GLP-1-Exendin-3-Gs/β1/γ2
21.88Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
21.88Single4DJHJDTic4DJH-κ-JDTic
21.88Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
21.88Single5D5AS-Carazolol5D5A-β2-S-Carazolol
21.88Single5D5BS-Carazolol5D5B-β2-S-Carazolol
21.88Single5V57TC1145V57-SMO-TC114
21.88Single5XRAAM115425XRA-CB1-AM11542
21.88Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
21.88Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
21.88Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
21.88Single6TQ7SB-3348676TQ7-OX1-SB-334867
21.88Single6WGTLSD6WGT-5-HT2A-LSD
21.88Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
21.88Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
21.88Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
21.88Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
21.88Single7T9NDPPC7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
21.88Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
21.88Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
21.88Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
21.88Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.88Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
21.88Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
21.88Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
21.88Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
21.88Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
21.88Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
21.88Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
21.88Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
21.88Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
21.88Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
21.88Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
21.88Single9I54A1IZV9I54-D1-A1IZV-Gs/β1/γ2
21.88Consensusa2_onOrthosteric Liganda2b_on
21.88Consensusa2_on_gpOrthosteric Liganda2b_on_gp
21.88Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
21.88Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
21.88Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
21.88Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
21.88Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
21.88Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
21.88Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
21.88Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
21.88Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
21.88Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
21.88Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
21.88Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
21.88Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
21.88Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
21.88Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
21.88Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
21.88Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
21.88Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
21.88Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
21.88Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
21.88Consensustachykinin_offOrthosteric Ligandnk1_off
21.88Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
21.62Single6W25SHU91196W25-MC4-SHU9119-Ca
21.62Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
21.62Single8W8YGamma-MSH8W8Y-MC3-γ-MSH-Ca-Gs/β1/γ2
21.43Single3OE9IT1t3OE9-CXCR4-IT1t
21.43Single5L7IVismodegib5L7I-SMO-Vismodegib
21.43Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
21.43Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
21.43Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
21.43Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
21.43Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
21.43Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
21.43Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
21.43Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
21.43Single9E7RGB889E7R-PAR2-GB88-chim(NtGi1L-Gs-CtGq)/β1/γ2
21.43Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
21.43Single9LMPNE52-QQ579LMP-GPR4-NE52-QQ57
21.43Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
21.43Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
21.28Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
21.28Consensusclass-b1_onOrthosteric Ligandglucagon_on vip-pacap_on pth_on crf_on calcitonin_on
21.21Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
21.21Single3D4STimolol3D4S-β2-Timolol
21.21Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
21.21Single4LDEBI1671074LDE-β2-BI167107
21.21Single4PY02MeSATP4PY0-P2Y12-2MeSATP
21.21Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
21.21Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
21.21Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
21.21Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
21.21Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
21.21Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
21.21Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
21.21Single7DFPSpiperone7DFP-D2-Spiperone
21.21Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
21.21Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
21.21Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
21.21Single7K15MKD0467K15-BLT1-MKD046-Na
21.21Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
21.21Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
21.21Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
21.21Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
21.21Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
21.21Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
21.21Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
21.21Single8Y6WTUG-13758Y6W-FFA2-TUG-1375-4-CMTB-Gi1/β1/γ2
21.21Single9EBIPiclidenoson9EBI-A3A-Piclidenoson-chim(NtGi1L-Gs-CtGi1)/β1/γ2
21.21Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
21.21Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
21.21Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
21.21Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
21.21Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
21.21Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
21.21Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
21.21Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
21.21Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
21.21Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
21.05Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
21.05Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
21.05Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
21.05Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
21.05Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ2
21.05Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
20.93Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
20.93Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
20.93Consensusglp1_onOrthosteric Ligand7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
20.69Single3ODUIT1t3ODU-CXCR4-IT1t
20.69Single3PWHZM-2413853PWH-A2A-ZM-241385
20.69Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
20.69Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
20.69Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
20.69Single5WS3EMPA5WS3-OX2-EMPA
20.69Single6B73MP11046B73-κ-MP1104
20.69Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
20.69Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
20.69Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
20.69Single7F8YDevazepide7F8Y-CCKA-Devazepide
20.69Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
20.69Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
20.69Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
20.69Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
20.69Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.69Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
20.69Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
20.69Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.69Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
20.69Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
20.69Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
20.69Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
20.69Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
20.69Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
20.69Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
20.69Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
20.69Single8YYWAlpha-ketoglutarate8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
20.69Single9EEAAdenosine9EEA-A2A-Adenosine-Gs/β1/γ2
20.69Single9H2XA1IR19H2X-A2A-A1IR1-Na
20.69Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
20.69Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
20.69Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
20.69Consensusorexin_offOrthosteric Ligandox2_off ox1_off
20.69Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
20.69Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
20.69Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
20.59Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
20.59Single6K1QIRL25006K1Q-ETB-IRL2500
20.59Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
20.59Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
20.59Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
20.59Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
20.59Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
20.59Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.59Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
20.59Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
20.59Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
20.59Single8S2TIsoprenaline8S2T-β1-Isoprenaline-chim(NtGi1-Gs)/β1/γ2
20.59Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
20.59Single9DYEBuspirone9DYE-5-HT1A-Buspirone-Go/β1/γ2
20.59Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
20.59Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
20.51Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
20.51Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
20.51Consensusvpac_onOrthosteric Ligandvpac1_on vpac2_on
20.45Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
20.45Consensusglp1_on_gpOrthosteric Ligand7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
20.41Consensuspth_on_gpOrthosteric Ligandpth1_on_gp pth2_on_gp
20.00Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
20.00Single2YDOAdenosine2YDO-A2A-Adenosine
20.00Single3REYXAC3REY-A2A-XAC
20.00Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
20.00Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
20.00Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
20.00Single4ZJCSB-6740424ZJC-OX1-SB-674042
20.00Single6FJ3PTH6FJ3-PTH1-PTH
20.00Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
20.00Single6KUXRS-799486KUX-α2a-RS-79948
20.00Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
20.00Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
20.00Single6PS0S-Carazolol6PS0-β2-S-Carazolol
20.00Single6PS4ICI118-5516PS4-β2-ICI118-551
20.00Single6PS5S-Propranolol6PS5-β2-S-Propranolol
20.00Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
20.00Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
20.00Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
20.00Single6TPGEMPA6TPG-OX2-EMPA
20.00Single6TPNHTL66416TPN-OX2-HTL6641
20.00Single6V9SGTPL114036V9S-OX1-GTPL11403
20.00Single6VI4JDTic6VI4-κ-JDTic
20.00Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
20.00Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
20.00Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
20.00Single6ZG9GSK10347026ZG9-M1-GSK1034702
20.00Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
20.00Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
20.00Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
20.00Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
20.00Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
20.00Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
20.00Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
20.00Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
20.00Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
20.00Single7UL3Famotidine7UL3-H2-Famotidine
20.00Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
20.00Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
20.00Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
20.00Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
20.00Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
20.00Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
20.00Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
20.00Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
20.00Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
20.00Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
20.00Single8IHKAcifran8IHK-HCA3-Acifran
20.00Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
20.00Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
20.00Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
20.00Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
20.00Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
20.00Single8K9LDamgo8K9L-μ-Damgo-BMS-986122-Gi3/β1/γ1
20.00Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
20.00Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
20.00Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
20.00Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
20.00Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
20.00Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
20.00Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
20.00Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
20.00Single9BA0A1AKN9BA0-CB1-A1AKN
20.00Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
20.00Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
20.00Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Gi1/β1/γ2
20.00Single9KPDSA09KPD-TAS2R16-SA0-chim(Gs-CtGt3)/β1/γ2
20.00Single9MD1Buspirone9MD1-5-HT1A-Buspirone-Gz/β1/γ2
20.00Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
20.00Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
20.00Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
20.00Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
20.00Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
20.00Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
20.00Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
20.00Consensusglucagon_onOrthosteric Ligandglp_on gluc_on secretin_on gip_on
20.00Consensuspac1_onOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
20.00Consensuspac1_on_gpOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
20.00Consensusvpac_on_gpOrthosteric Ligandvpac1_on_gp vpac2_on_gp
19.61Consensusclass-b1_on_gpOrthosteric Ligandglucagon_on_gp vip-pacap_on_gp pth_on_gp crf_on_gp calcitonin_on_gp
19.57Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
19.57Consensusglucagon_on_gpOrthosteric Ligandglp_on_gp gluc_on_gp secretin_on_gp gip_on_gp
19.51Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
19.51Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
19.51Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
19.51Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
19.51Single9BUCCagrilintide9BUC-CT-Cagrilintide-Gs/β1/γ2
19.51Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
19.44Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
19.44Single8IEBA1LYA8IEB-GPR156-A1LYA
19.44Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
19.44Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
19.44Single9M4TSilodosin9M4T-Alpha1A-Silodosin
19.35Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
19.35Single2Y01Dobutamine2Y01-β1-Dobutamine
19.35Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
19.35Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
19.35Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
19.35Single4QKX35V4QKX-β2-35V
19.35Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
19.35Single5DHGC-355DHG-NOP-C-35
19.35Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
19.35Single5T04Neurotensin5T04-NTS1-Neurotensin
19.35Single5TGZAM65385TGZ-CB1-AM6538
19.35Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
19.35Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
19.35Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
19.35Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
19.35Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
19.35Single6PS1Timolol6PS1-β2-Timolol
19.35Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
19.35Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
19.35Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
19.35Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
19.35Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
19.35Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
19.35Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
19.35Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
19.35Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
19.35Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
19.35Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
19.35Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
19.35Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
19.35Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
19.35Single7WC7Lisuride7WC7-5-HT2A-Lisuride
19.35Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
19.35Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
19.35Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
19.35Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
19.35Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
19.35Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
19.35Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
19.35Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
19.35Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
19.35Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
19.35Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
19.35Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.35Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.35Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.35Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.35Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.35Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.35Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.35Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.35Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.35Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.35Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
19.35Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
19.35Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
19.35Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
19.35Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
19.35Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
19.35Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
19.35Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
19.35Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
19.35Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
19.35Single8JJOAlprenolol8JJO-β2-Alprenolol
19.35Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
19.35Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
19.35Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
19.35Single8K5DGSK2560738K5D-HCA2-GSK256073
19.35Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
19.35Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
19.35Single8PJKST1718PJK-5-HT1A-ST171-Gi1/β1/γ1
19.35Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
19.35Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.35Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.35Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.35Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.35Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
19.35Single8X63Mepyramine8X63-H1-Mepyramine
19.35Single8X64Desloratadine8X64-H1-Desloratadine
19.35Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
19.35Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
19.35Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
19.35Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
19.35Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
19.35Single9IZCMK19039IZC-HCA2-MK1903-Gi1/β1/γ2
19.35Single9JGKBalovaptan9JGK-5-HT2B-Balovaptan
19.35Single9PQD(6m)-1-methyl-6-(1,2,5,6-tetrahydropyridin-3-yl)-1h-indole9PQD-α2a-(6m)-1-methyl-6-(1,2,5,6-tetrahydropyridin-3-yl)-1h-indole
19.35Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
19.35Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
19.35Consensus5ht5_onOrthosteric Ligand5ht5a_on
19.35Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
19.35Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
19.35Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
19.35Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
19.35Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
19.35Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
19.35Consensusalpha2_onOrthosteric Ligandalpha2b_on
19.35Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
19.35Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
19.35Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
19.35Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
19.35Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
19.35Consensusblt_onOrthosteric Ligandblt1_on
19.35Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
19.35Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
19.35Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
19.35Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
19.35Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
19.35Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
19.35Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
19.35Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
19.35Consensushca_on_gpOrthosteric Ligandhca2_on_gp
19.35Consensushistamine_offOrthosteric Ligandh1_off
19.35Consensusleukotriene_onOrthosteric Ligandblt_on
19.35Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
19.23Single7V68LY21196207V68-M4-Iperoxo-LY2119620-Gi1/β1/γ2
19.05Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
19.05Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
19.05Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
19.05Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
19.05Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
19.05Single9BQ3Cagrilintide9BQ3-CT (AMY2)-Cagrilintide-Gs/β1/γ2; RAMP2
18.92Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
18.92Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
18.92Single8IEBA1LYA8IEB-GPR156-A1LYA
18.92Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
18.75Single4NTJAZD12834NTJ-P2Y12-AZD1283
18.75Single5JQHS-Carazolol5JQH-β2-S-Carazolol
18.75Single5TVNLSD5TVN-5-HT2B-LSD
18.75Single5WIUNemonapride5WIU-D4-Nemonapride
18.75Single5WIVNemonapride5WIV-D4-Nemonapride-Na
18.75Single5WQCEMPA5WQC-OX2-EMPA
18.75Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
18.75Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
18.75Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
18.75Single6HLPNetupitant6HLP-NK1-Netupitant
18.75Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
18.75Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
18.75Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
18.75Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
18.75Single6PS6Timolol6PS6-β2-Timolol
18.75Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
18.75Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
18.75Single6TP6Filorexant6TP6-OX1-Filorexant
18.75Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
18.75Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
18.75Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
18.75Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
18.75Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
18.75Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
18.75Single7WC6LSD7WC6-5-HT2A-LSD
18.75Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
18.75Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
18.75Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
18.75Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
18.75Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
18.75Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
18.75Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
18.75Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
18.75Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
18.75Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
18.75Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
18.75Single8WGBVU01550418WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
18.75Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
18.75Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
18.75Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
18.75Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
18.75Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
18.75Single9B9ZA1AKO9B9Z-CB1-A1AKO
18.75Single9F33FOB02-04A9F33-D3-FOB02-04A-Go/β1/γ2
18.75Single9GE2ML1849GE2-GPR55-ML184-chim(NtGi1-G13)/β1/γ2
18.75Single9HAPTolvaptan9HAP-V2-Tolvaptan
18.75Single9KPFSA09KPF-TAS2R16-SA0-Gi1/β1/γ2
18.75Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
18.75Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
18.75Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
18.75Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
18.75Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
18.75Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
18.75Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
18.75Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
18.75Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
18.75Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
18.75Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
18.75Consensuspth2_on_gpOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
18.75Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
18.60Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
18.52Single3OE8IT1t3OE8-CXCR4-IT1t
18.52Single6TQ9SB-4081246TQ9-OX1-SB-408124
18.52Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
18.52Single8A2OTheophylline8A2O-A2A-Theophylline-Na
18.52Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
18.42Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
18.42Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
18.42Consensusclass-b1_class-b2_cons_onOrthosteric Ligandclass-b1_on class-b2_on
18.42Consensusclass-b1_class-b2_cons_on_gpOrthosteric Ligandclass-b1_on_gp class-b2_on_gp
18.37Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
18.18Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
18.18Single4U15Tiotropium4U15-M3-Tiotropium
18.18Single5XR8AM8415XR8-CB1-AM841
18.18Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
18.18Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
18.18Single6E59L-7607356E59-NK1-L-760735
18.18Single6H7JIsoprenaline6H7J-β1-Isoprenaline
18.18Single6J20Aprepitant6J20-NK1-Aprepitant
18.18Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
18.18Single6OL9Tiotropium6OL9-M5-Tiotropium
18.18Single7B6WCyclazosin7B6W-α1b-Cyclazosin
18.18Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
18.18Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
18.18Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
18.18Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
18.18Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
18.18Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
18.18Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
18.18Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
18.18Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
18.18Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
18.18Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
18.18Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
18.18Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
18.18Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
18.18Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
18.18Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
18.18Single9EGOYVF9EGO-CB1-YVF-Gi1/β1/γ2
18.18Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
18.18Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
18.18Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
18.18Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
18.18Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
18.18Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
18.18Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
18.18Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
18.18Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
17.95Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
17.95Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
17.95Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
17.95Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
17.95Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
17.95Single9EBOGLP-1 (ACPC18)9EBO-GLP-1-GLP-1 (ACPC18)-Gs/β1/γ2
17.86Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
17.86Single6ME5Agomelatine6ME5-MT1-Agomelatine
17.86Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
17.86Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
17.86Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
17.86Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
17.86Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
17.86Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
17.86Single8JPSCCL78JPS-ACKR1-CCL7
17.86Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
17.86Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
17.86Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
17.86Single9JHJC18:0 Ceramide9JHJ-FPR2-ALX-C18:0 Ceramide-Gi1/β1/γ2
17.86Consensus5ht2_onOrthosteric Ligand5ht2b_on
17.86Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.86Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
17.86Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
17.86Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
17.78Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
17.78Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
17.78Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
17.78Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
17.65Single4N4WSANT-14N4W-SMO-SANT-1
17.65Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
17.65Single5CXVTiotropium5CXV-M1-Tiotropium
17.65Single5TZYMK8666; AP85TZY-FFA1-MK8666; AP8
17.65Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
17.65Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
17.65Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
17.65Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
17.65Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
17.65Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
17.65Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.65Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
17.65Single8JD3JNJ-404118138JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
17.65Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
17.65Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
17.65Single9CM3TUG-13759CM3-FFA2-TUG-1375-Compound 187-chim(NtGi1L-Gs-CtGq)/β1/γ2
17.65Single9DGIZ85267113509DGI-CB1-Z8526711350
17.65Single9GL2Befiradol9GL2-5-HT1A-Befiradol-Gs/β1/γ2
17.65Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
17.65Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
17.65Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
17.65Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
17.65Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
17.65Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
17.50Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
17.50Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
17.50Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
17.39Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
17.39Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
17.24Single3PBLEticlopride3PBL-D3-Eticlopride
17.24Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
17.24Single6HLLCP999946HLL-NK1-CP99994
17.24Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
17.24Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
17.24Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
17.24Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
17.24Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
17.24Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
17.24Single7SRQLSD7SRQ-5-HT2B-LSD
17.24Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
17.24Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
17.24Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
17.24Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
17.24Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
17.24Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
17.24Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
17.24Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab
17.24Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
17.24Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
17.24Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
17.24Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
17.24Single9B9Y7DY9B9Y-CB1-7DY
17.24Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
17.24Single9IXJHistamine9IXJ-H2-Histamine-Gs/β1/γ2
17.24Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
17.24Consensusgq_nucleotideOrthosteric Ligandgq_p2y
17.24Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
17.14Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
17.14Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
17.14Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
17.14Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
17.14Single7UM4AS26747237UM4-5-HT5A-AS2674723
17.14Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
17.14Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
17.14Single8XVJMacitentan8XVJ-ETA-Macitentan
17.14Single9AS02-bromo-LSD9AS0-5-HT2A-2-bromo-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
17.14Single9C0KExendin-49C0K-GLP-1-Exendin-4-Gs/β1/γ2
17.14Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
17.14Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
17.07Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
17.07Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
17.07Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
17.07Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
17.07Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
17.07Single9BLBCagrilintide backbone (non-acylated)9BLB-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
17.07Single9BP3Cagrilintide9BP3-CT (AMY1)-Cagrilintide-Gs/β1/γ2; RAMP1
17.07Consensusvpac1_on_gpOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
16.67Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
16.67Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
16.67Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
16.67Single4S0VSuvorexant4S0V-OX2-Suvorexant
16.67Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
16.67Single5ZKQABT-4915ZKQ-PAF-ABT-491
16.67Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
16.67Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
16.67Single6ME9Ramelteon6ME9-MT2-Ramelteon
16.67Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
16.67Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
16.67Single6TODEMPA6TOD-OX1-EMPA-Na
16.67Single6TPJSuvorexant6TPJ-OX2-Suvorexant
16.67Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
16.67Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
16.67Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
16.67Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
16.67Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
16.67Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
16.67Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
16.67Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
16.67Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
16.67Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
16.67Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
16.67Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
16.67Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
16.67Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
16.67Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
16.67Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
16.67Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
16.67Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
16.67Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
16.67Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
16.67Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
16.67Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
16.67Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
16.67Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
16.67Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
16.67Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
16.67Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.67Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
16.67Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
16.67Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
16.67Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
16.67Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
16.67Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
16.67Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
16.67Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
16.67Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.67Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.67Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.67Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
16.67Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
16.67Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
16.67Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
16.67Single8Y0HVUF114188Y0H-CXCR3-VUF11418
16.67Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go/β1/γ2
16.67Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ2
16.67Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
16.67Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
16.67Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
16.67Single9CM7TUG-13759CM7-FFA2-TUG-1375-AZ-1729-Gi1/β1/γ2
16.67Single9EBHAdenosine9EBH-A3A-Adenosine-Gi1/β1/γ2
16.67Single9JF4PD1683689JF4-BB1-PD168368
16.67Single9K6LSA09K6L-TAS2R16-SA0-Gi2/β1/γ2
16.67Single9KPESA09KPE-TAS2R16-SA0-Gi1/β1/γ2
16.67Single9LRBHistamine9LRB-H1-Histamine-Gs/β1/γ2
16.67Single9NS9TUG-13759NS9-FFA2-TUG-1375-Compound 187-Gi1/β1/γ2
16.67Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
16.67Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
16.67Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
16.67Consensusalpha2_offOrthosteric Ligandalpha2c_off
16.67Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
16.67Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
16.67Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
16.67Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
16.67Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
16.67Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
16.67Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
16.67Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
16.67Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
16.28Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
16.28Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
16.28Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
16.28Consensuspth1_onOrthosteric Ligand6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
16.22Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
16.22Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
16.22Single7QA8Peptide7QA8-STE2-Peptide
16.22Single7QA8Peptide7QA8-STE2-Peptide
16.22Single8IEIA1LYA8IEI-GPR156-A1LYA
16.22Single8IEIA1LYA8IEI-GPR156-A1LYA
16.22Single8IEPA1LYA8IEP-GPR156-A1LYA
16.22Single8IEPA1LYA8IEP-GPR156-A1LYA
16.22Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
16.22Single8YWFRetatrutide8YWF-GLP-1-Retatrutide-chim(NtGi1-Gs)/β1/γ2
16.13Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
16.13Single3RZECidoxepin3RZE-H1-Cidoxepin
16.13Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
16.13Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
16.13Single6A94Zotepine6A94-5-HT2A-Zotepine
16.13Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
16.13Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
16.13Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
16.13Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
16.13Single6TP3Nemorexant6TP3-OX1-Nemorexant
16.13Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
16.13Single6ZINSR486926ZIN-NTS1-SR48692
16.13Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
16.13Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
16.13Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
16.13Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
16.13Single7T94Acetylcholine7T94-M2-Acetylcholine-LY2119620-chim(NtGi1-Go)/β1/γ2
16.13Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
16.13Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
16.13Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
16.13Single7VV6C48/807VV6-MRGPRX2-C48/80
16.13Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
16.13Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
16.13Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
16.13Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
16.13Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
16.13Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
16.13Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
16.13Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
16.13Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
16.13Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
16.13Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
16.13Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.13Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.13Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
16.13Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
16.13Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
16.13Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
16.13Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
16.13Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
16.13Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
16.13Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
16.13Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
16.13Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
16.13Single8K5CAcipimox8K5C-HCA2-Acipimox
16.13Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
16.13Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
16.13Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.13Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.13Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
16.13Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.13Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
16.13Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
16.13Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
16.13Single9ARXSerotonin9ARX-5-HT2A-Serotonin
16.13Single9AS5Mescaline9AS5-5-HT2A-Mescaline
16.13Single9AS6Mescaline9AS6-5-HT2A-Mescaline-chim(NtGi1-Gs-CtGq)/β1/γ2
16.13Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
16.13Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
16.13Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
16.13Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
16.13Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
16.13Single9IXXLTD49IXX-CysLT2-LTD4-chim(NtGi1-Gs-CtGq)/β1/γ2
16.13Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
16.13Single9LRDHistamine9LRD-H1-Histamine-Gi1/β1/γ2
16.13Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
16.13Consensushca_onOrthosteric Ligandhca2_on
16.13Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
16.13Consensusopsins_offOrthosteric Ligandrhodopsin_off
16.13Consensussensory_offOrthosteric Ligandopsins_off
15.91Single7RBTTirzepatide7RBT-GIP-Tirzepatide-LSN3556672-chim(NtGi1-Gs)/β1/γ2
15.69Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
15.62Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
15.62Single2Y04Salbutamol2Y04-β1-Salbutamol
15.62Single4DAJTiotropium4DAJ-M3-Tiotropium
15.62Single4MQSIperoxo4MQS-M2-Iperoxo
15.62Single4U14Tiotropium4U14-M3-Tiotropium
15.62Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
15.62Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
15.62Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
15.62Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
15.62Single6DRXLisuride6DRX-5-HT2B-Lisuride
15.62Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
15.62Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
15.62Single6GPSMK08126GPS-CCR2-MK0812
15.62Single6H7MSalbutamol6H7M-β1-Salbutamol
15.62Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
15.62Single7F83PF-051904577F83-Ghrelin-PF-05190457
15.62Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
15.62Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
15.62Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
15.62Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
15.62Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
15.62Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
15.62Single7YXAONO-54306087YXA-S1P5-ONO-5430608
15.62Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
15.62Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
15.62Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
15.62Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
15.62Single9AS1DMT9AS1-5-HT2A-DMT
15.62Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
15.62Single9IMATalquetamab9IMA-GPRC5D-Talquetamab
15.62Single9JEAAtropine9JEA-M1-Atropine
15.62Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
15.62Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
15.62Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
15.62Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
15.62Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
15.62Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
15.62Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
15.62Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
15.38Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
15.38Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
15.38Single9B5YLong-Acting PTH9B5Y-PTH1-Long-Acting PTH-chim(NtGi1-Gq)/β1/γ2
15.38Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
15.38Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
15.22Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
15.22Consensuspth1_on_gpOrthosteric Ligand6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
15.15Single2Y03Isoprenaline2Y03-β1-Isoprenaline
15.15Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
15.15Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
15.15Single6GPXMK08126GPX-CCR2-MK0812
15.15Single6LUQHaloperidol6LUQ-D2-Haloperidol
15.15Single6Z4SSR486926Z4S-NTS1-SR48692
15.15Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
15.15Single7SINNPS-21437SIN-CaS-NPS-2143
15.15Single7SINNPS-21437SIN-CaS-NPS-2143
15.15Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
15.15Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
15.15Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.15Single8XYKVUF106618XYK-CXCR3-VUF10661-Go/β1/γ2
15.15Single8ZMFA1L108ZMF-5-HT2C-A1L10
15.15Single9ARYSerotonin9ARY-5-HT2A-Serotonin-chim(NtGi1-Gs-CtGq)/β1/γ2
15.15Single9DYDAsenapine9DYD-5-HT1A-Asenapine-Go/β1/γ2
15.15Single9DYFAsenapine9DYF-5-HT1A-Asenapine-Gi1/β1/γ2
15.15Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
15.15Consensusblt_offOrthosteric Ligandblt1_off
15.15Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
15.15Consensusep_offOrthosteric Ligandep4_off
15.15Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
15.15Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
15.15Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
15.15Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.15Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.00Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
15.00Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
15.00Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
15.00Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
15.00Single9BLCCagrilintide backbone (non-acylated)9BLC-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
15.00Single9BUDCagrilintide9BUD-CT-Cagrilintide-Gs/β1/γ2
14.89Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
14.81Single3PXOAll-trans-Retinal3PXO-Rhodopsin-All-trans-Retinal
14.81Single5DYSAll-trans-Retinal5DYS-Rhodopsin-All-trans-Retinal
14.81Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
14.81Single7WC4Serotonin7WC4-5-HT2A-Serotonin
14.81Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
14.81Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
14.81Single8PWNTheophylline8PWN-A2A-Theophylline
14.81Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
14.71Single5TZRMK86665TZR-FFA1-MK8666
14.71Single5V54Methiothepin5V54-5-HT1B-Methiothepin
14.71Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
14.71Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
14.71Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
14.71Single8EA0Iperoxo8EA0-M3-Iperoxo
14.71Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
14.71Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
14.71Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
14.71Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
14.71Single9CLWTUG-13759CLW-FFA2-TUG-1375-4-CMTB-chim(NtGi1L-Gs-CtGq)/β1/γ2
14.71Consensus5ht1_offOrthosteric Ligand5ht1b_off
14.71Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
14.71Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
14.71Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
14.71Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
14.63Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
14.63Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
14.63Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
14.63Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
14.63Consensuscalcitonin_onOrthosteric Ligandctlike_on
14.63Consensusvpac1_onOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
14.29Single3RFMCaffeine3RFM-A2A-Caffeine
14.29Single5X33BIIL2605X33-BLT1-BIIL260
14.29Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
14.29Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
14.29Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
14.29Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
14.29Single6OY9All-trans-Retinal6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
14.29Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
14.29Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
14.29Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
14.29Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single8IWM2-Phenylethylamine8IWM-TA9-2-Phenylethylamine
14.29Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Gi1/β1/γ2
14.29Single8WC5Tetramethylammonium Ion8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
14.29Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
14.29Single8XYIVUF106618XYI-CXCR3-VUF10661
14.29Single9BJKNAM9BJK-μ-Naloxone-NAM
14.29Single9BUBCagrilintide9BUB-CT-Cagrilintide-Gs/β1/γ2
14.29Single9CHUNoradrenaline9CHU-β2-Noradrenaline
14.29Single9GGGI-BOP9GGG-TXA2-I-BOP-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29Consensuscalcitonin_on_gpOrthosteric Ligandctlike_on_gp
14.29Consensusgs_histamineOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
14.29Consensush2_onOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
14.29Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
14.29Consensussensory_onOrthosteric Ligandopsins_on
13.95Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
13.95Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
13.95Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
13.95Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
13.95Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
13.89Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
13.89Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
13.89Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
13.89Single9GG5U466199GG5-TXA2-U46619-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.89Single9JH5C16:0 Ceramide9JH5-CysLT2-C16:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
13.89Consensusfp-alpha_onOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
13.89Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
13.79Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
13.79Single3PQRAll-trans-Retinal3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
13.79Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
13.79Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
13.79Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
13.79Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
13.79Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
13.79Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
13.79Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
13.79Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
13.79Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
13.79Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.79Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
13.79Single8IW72-Phenylethylamine8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
13.79Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
13.79Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
13.79Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
13.79Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
13.79Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
13.79Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
13.79Single9LRCHistamine9LRC-H4-Histamine
13.79Single9LREHistamine9LRE-H4-Histamine-Gi1/β1/γ2
13.79Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
13.79Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
13.79Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
13.79Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
13.79Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
13.64Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
13.64Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
13.64Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
13.64Consensusvpac2_on_gpOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
13.51Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
13.51Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
13.51Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
13.51Single9JH6C20:0 Ceramide9JH6-CysLT2-C20:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
13.33Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
13.33Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
13.33Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
13.33Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
13.33Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
13.33Single6LI0C176LI0-GPR52-C17
13.33Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
13.33Single6TP4ACT-4622066TP4-OX1-ACT-462206
13.33Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
13.33Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
13.33Single7UL2SR486927UL2-NTS1-SR48692-Na
13.33Single7V68Iperoxo7V68-M4-Iperoxo-LY2119620-Gi1/β1/γ2
13.33Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
13.33Single7XP6Strychnine7XP6-TAS2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
13.33Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
13.33Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
13.33Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.33Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
13.33Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
13.33Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
13.33Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
13.33Single8K5BNiacin8K5B-HCA2-Niacin
13.33Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
13.33Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
13.33Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.33Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
13.33Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
13.33Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
13.33Single8YN7Immethridine8YN7-H3-Immethridine-Go/β1/γ2
13.33Single9AS2DMT9AS2-5-HT2A-DMT-chim(NtGi1-Gs-CtGq)/β1/γ2
13.33Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
13.33Single9EPRRetinal9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
13.33Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
13.33Single9IZDCHBA9IZD-HCA1-CHBA-Gi1/β1/γ2
13.33Consensuscrf1_onOrthosteric Ligand6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF1-Corticoliberin-Gs/β1/γ2
13.33Consensusgip_onOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
13.33Consensusgip_on_gpOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
13.33Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
13.33Consensusneurotensin_offOrthosteric Ligandnts1_off
13.33Consensusnts1_offOrthosteric Ligand7UL2-NTS1-SR48692-Na
13.16Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
13.16Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
13.16Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.16Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
13.16Single8KIGSHU91198KIG-MC3-SHU9119-Ca
13.16Single9BUECagrilintide9BUE-CT-Cagrilintide-Gs/β1/γ2
13.04Single9AUCCalcitonin gene-related peptide-19AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
12.90Single5U09Taranabant5U09-CB1-Taranabant
12.90Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
12.90Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
12.90Single6ME2Ramelteon6ME2-MT1-Ramelteon
12.90Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
12.90Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
12.90Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
12.90Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
12.90Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
12.90Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
12.90Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
12.90Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
12.90Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
12.90Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
12.90Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
12.90Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
12.90Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
12.90Single8IWESpermidine8IWE-TA9-Spermidine
12.90Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
12.90Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
12.90Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
12.90Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
12.90Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
12.90Consensusangiotensin_offOrthosteric Ligandat1_off
12.90Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
12.90Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
12.90Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
12.90Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
12.90Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
12.90Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
12.90Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
12.90Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
12.82Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
12.82Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
12.82Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
12.77Consensuscrf1_on_gpOrthosteric Ligand6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF1-Corticoliberin-Gs/β1/γ2
12.50Single6TPKRetosiban6TPK-OT-Retosiban
12.50Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
12.50Single7VODCariprazine7VOD-5-HT2A-Cariprazine
12.50Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
12.50Single8K2WAMG4878K2W-CXCR3-AMG487
12.50Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
12.50Single9AS3LSD9AS3-5-HT2A-LSD
12.50Single9AS4LSD9AS4-5-HT2A-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
12.50Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
12.50Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
12.50Consensusvasop-oxy_offOrthosteric Ligandot_off
12.24Consensusgluc_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
12.20Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
12.20Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
12.12Single4YAYZD-71554YAY-AT1-ZD-7155
12.12Single5DSGTiotropium5DSG-M4-Tiotropium
12.12Single6IIVDaltroban6IIV-TXA2-Daltroban
12.12Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/β1/γ2
12.12Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.12Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
12.12Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
12.12Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
12.12Single8YN8Proxyfan8YN8-H3-Proxyfan-Go/β1/γ2
12.12Single9IYAONO-97105319IYA-GPR55-ONO-9710531
12.12Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
12.12Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
12.12Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
12.00Consensusgluc_on_gpOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
11.76Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
11.76Single5CGCHTL142425CGC-mGlu5-HTL14242
11.76Single5T1ABMS-6815T1A-CCR2-BMS-681-PubChem 12093170
11.76Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
11.76Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
11.76Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
11.76Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
11.76Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
11.76Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
11.76Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
11.76Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
11.76Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
11.76Single9ARZ2-bromo-LSD9ARZ-5-HT2A-2-bromo-LSD
11.76Consensusadgrg2_onOrthosteric Ligand7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
11.76Consensusadgrg2_on_gpOrthosteric Ligand7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
11.63Consensuscrf2_on_gpOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
11.63Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
11.63Consensussecretin_onOrthosteric Ligand7D3S-Secretin-Secretin-Gs/β1/γ2
11.43Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
11.43Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
11.43Single8YNTSNAP-948478YNT-MCH1-SNAP-94847
11.43Single8ZW0PGD28ZW0-DP1-PGD2-Gs/β1/γ2
11.43Single9AS9RS130-1809AS9-5-HT2A-RS130-180
11.43Single9ASARS130-1809ASA-5-HT2A-RS130-180-chim(NtGi1-Gs-CtGq)/β1/γ2
11.36Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
11.36Consensussecretin_on_gpOrthosteric Ligand7D3S-Secretin-Secretin-Gs/β1/γ2
11.11Single4A4MAll-trans-Retinal4A4M-Rhodopsin-All-trans-Retinal-Gt(CT)
11.11Single5EN0All-trans-Retinal5EN0-Rhodopsin-All-trans-Retinal-Gt(CT)
11.11Single5MZPCaffeine5MZP-A2A-Caffeine-Na
11.11Single6IIURamatroban6IIU-TXA2-Ramatroban
11.11Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
11.11Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.11Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
11.11Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
11.11Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single8XJNCloprosetnol8XJN-TXA2-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single9BTWCagrilintide9BTW-CT (AMY3)-Cagrilintide-Gs/β1/γ2; RAMP3
11.11Consensusctlike_on_gpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
10.81Single5CGDHTL142425CGD-mGlu5-HTL14242
10.81Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
10.81Single8XJOU466198XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
10.81Single9M1HProstaglandin E29M1H-EP1-Prostaglandin E2-chim(NtGi1-Gs-CtGq)/β1/γ2
10.81Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
10.81Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
10.81Consensustp_onOrthosteric Ligand8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
10.81Consensustp_on_gpOrthosteric Ligand8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
10.71Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
10.53Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
10.53Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
10.34Single2HPYAll-trans-Retinal2HPY-Rhodopsin-All-trans-Retinal
10.34Single6XBM5LWE6XBM-SMO-5LWE-Gi1/β1/γ2
10.34Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
10.34Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
10.34Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
10.34Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
10.34Single9EE9Adenosine9EE9-A2A-Adenosine-Gs/β1/γ2
10.00Single3UZAGTPL92363UZA-A2A-GTPL9236
10.00Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.00Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
10.00Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
10.00Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
10.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
10.00Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
10.00Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
10.00Consensusgi_sensoryOrthosteric Ligandgi_opsins
10.00Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
10.00Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
9.68Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
9.68Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.68Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
9.68Single8HSCFab0468HSC-GPR20-Fab046-Gi1/β1/γ2
9.68Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
9.68Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
9.68Single8YN2Histamine8YN2-H1-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
9.68Single8ZYUNeurotensin peptide 8-138ZYU-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
9.68Single9AS7Psilocin9AS7-5-HT2A-Psilocin
9.68Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg4_on
9.68Consensusadgrg_on_gpOrthosteric Ligandadgrg2_on_gp adgrg4_on_gp
9.68Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
9.52Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
9.38Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
9.38Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
9.38Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.38Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.38Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
9.09Single8YRGFospropofol8YRG-MRGPRX4-Fospropofol-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
8.89Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
8.89Consensusglp2_on_gpOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
8.82Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
8.82Single9IVGGLP-1 (Truncated)9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
8.57Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
8.57Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
8.57Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
8.57Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
8.57Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
8.57Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
8.57Single9HC04YI9HC0-mGlu5-4YI
8.33Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
8.33Single7P2L4YI7P2L-mGlu5-4YI
8.33Single8GDBPGE28GDB-EP4-PGE2-Gs/β1/γ2
8.33Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Single8JD5JNJ-40411813; ADX881788JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
8.33Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
8.33Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
8.11Single9AU0BW245C9AU0-DP1-BW245C-Gs/β1/γ2
7.89Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
7.69Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
7.50Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
7.41Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
7.14Single8GEJConstrained Epinephrine8GEJ-β2-Constrained Epinephrine-Gs/β1/γ2
6.90Single7XKDBeta-Hydroxyandrosterone7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
6.90Single8HS2Fab0468HS2-GPR20-Fab046
6.90Single8X9S5alpha-DHT8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
6.67Single8Y02Retinal8Y02-OPN1SW-Retinal-Gi1/β1/γ2
6.45Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
6.45Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
6.45Single8J6QCompound 9n8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
6.25Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
6.25Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
6.25Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
6.25Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/β1/γ2
6.25Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
6.06Single8T3VDocosa-4,7,10,13,16,19-Hexaenoic acid8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.88Single6FFIMMPEP6FFI-mGlu5-MMPEP
5.88Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
5.71Single6FFHFenobam6FFH-mGlu5-Fenobam
5.56Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.56Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
5.56Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
5.56Single8ZVZBW245C8ZVZ-DP1-BW245C-Gs/β1/γ2
5.41Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
5.41Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
3.85Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
3.85Single6D35Cholesterol6D35-SMO-Cholesterol
3.85Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
3.85Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
3.85Single6UO8SKF975416UO8-GABAB1, GABAB2-SKF97541-GS39783
3.85Single6UO9SKF975416UO9-GABAB1, GABAB2-SKF97541
3.85Single6W2XPubChem 53110426W2X-GABAB1, GABAB2-PubChem 5311042
3.85Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042
3.85Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042
3.85Single7C7QBaclofen7C7Q-GABAB1, GABAB2-Baclofen-BHFF
3.85Single7C7SCGP546267C7S-GABAB1, GABAB2-CGP54626
3.85Single7CUMCGP546267CUM-GABAB1, GABAB2-CGP54626
3.85Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
3.85Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
3.85Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
3.85Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
3.85Single7DGEQuisqualate7DGE-mGlu1; mGlu1-Quisqualate
3.85Single7DTTCa7DTT-CaS-Ca-Ca
3.85Single7DTTCa7DTT-CaS-Ca-Ca
3.85Single7DTUTryptophan7DTU-CaS-Tryptophan
3.85Single7DTUTryptophan7DTU-CaS-Tryptophan
3.85Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
3.85Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
3.85Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
3.85Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
3.85Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
3.85Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
3.85Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
3.85Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
3.85Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
3.85Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
3.85Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
3.85Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
3.85Single7EB2Baclofen7EB2-GABAB2; GABAB1-Baclofen-rac-BHFF-Gi1/β1/γ2
3.85Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
3.85Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
3.85Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
3.85Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
3.85Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
3.85Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
3.85Single7FIHhCG7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
3.85Single7FIIhCG7FII-LH-hCG-chim(NtGi1-Gs)/β1/γ2
3.85Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
3.85Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
3.85Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
3.85Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
3.85Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
3.85Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
3.85Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
3.85Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
3.85Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
3.85Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
3.85Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
3.85Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
3.85Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
3.85Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
3.85Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
3.85Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
3.85Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
3.85Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
3.85Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
3.85Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
3.85Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
3.85Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
3.85Single7T9NM22 Fab7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
3.85Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
3.85Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
3.85Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
3.85Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
3.85Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
3.85Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
3.85Single7XW6M22 Fab7XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
3.85Single7XW7K1-707XW7-TSH-K1-70
3.85Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
3.85Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
3.85Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
3.85Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
3.85Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
3.85Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
3.85Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
3.85Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
3.85Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
3.85Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
3.85Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
3.85Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
3.85Single8JD0Glutamate8JD0-mGlu2; mGlu3-Glutamate-NAM563
3.85Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
3.85Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
3.85Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
3.85Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
3.85Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
3.85Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
3.85Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
3.85Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
3.85Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
3.85Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
3.85Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
3.85Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
3.85Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
3.85Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
3.85Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
3.85Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
3.85Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
3.85Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
3.85Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
3.85Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
3.85Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
3.85Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
3.85Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
3.85Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
3.85Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
3.85Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
3.85Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
3.85Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
3.85Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
3.85Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
3.85Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
3.85Single8WG9(2S)-2-amino-4-phosphonobutanoic acid8WG9-mGlu4; mGlu2-(2S)-2-amino-4-phosphonobutanoic acid
3.85Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
3.85Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
3.85Single8WGCLY3792688WGC-mGlu4; mGlu2-LY379268
3.85Single8WGDWAG; WA68WGD-mGlu4; mGlu2-WAG; WA6
3.85Single8WGDWAG; WA68WGD-mGlu4; mGlu2-WAG; WA6
3.85Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
3.85Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
3.85Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.85Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.85Single8WVXNorrin8WVX-LGR4-Norrin
3.85Single8WVYNorrin8WVY-LGR4-Norrin
3.85Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
3.85Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
3.85Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
3.85Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
3.85Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
3.85Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
3.85Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
3.85Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
3.85Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
3.85Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
3.85Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
3.85Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
3.85Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
3.85Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
3.85Single8XUMR-spondin-28XUM-LGR4-R-spondin-2
3.85Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
3.85Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
3.85Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
3.85Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
3.85Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
3.85Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
3.85Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
3.85Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
3.85Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
3.85Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
3.85Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
3.85Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
3.85Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
3.85Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
3.85Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
3.85Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
3.85Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
3.85Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
3.85Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
3.85Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
3.85Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
3.85Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
3.85Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
3.85Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
3.85Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
3.85Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
3.85Single9KHHNorrin9KHH-LGR4-Norrin
3.85Single9S37NB219S37-LGR4-NB21
3.85Single9UTBSucralose9UTB-TAS1R2; TAS1R3-Sucralose
3.70Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
3.70Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
3.70Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
3.70Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
3.70Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
3.70Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
3.70Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
3.70Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
3.70Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
3.70Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
3.70Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
3.70Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
3.70Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
3.70Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
3.70Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
3.70Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
3.70Consensusclass-b2_onOrthosteric Ligandadgrg_on adgrf_on adgrl_on adgre_on adgrd_on
3.70Consensusclass-b2_on_gpOrthosteric Ligandadgrg_on_gp adgrf_on_gp adgrl_on_gp adgre_on_gp adgrd_on_gp
3.57Single7KNUCalcitonin gene-related peptide-17KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
3.57Single7T9MCS-17 Antibody7T9M-TSH-CS-17 Antibody
3.57Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
3.45Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
3.45Single7FIGhCG7FIG-LH-hCG-chim(NtGi1L-Gs)/β1/γ2
3.45Single7UTZTR14027UTZ-TSH-TR1402-DPPC-Gs/β1/γ2
3.45Single7XW5TSH7XW5-TSH-TSH-ML109-Gs/β1/γ2
3.45Single7ZI0Cholesterol7ZI0-SMO-SAG-Cholesterol
3.45Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/β1/γ2
3.33Single5L7DCholesterol5L7D-SMO-Cholesterol
3.33Single7T9ITSH7T9I-TSH-TSH-Gs/β1/γ2
3.33Single8I2GGlycoprotein hormones alpha chain8I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
3.23Single7Y14Beta-Alanine7Y14-MRGPRD-β-Alanine
3.12Single7Y12Beta-Alanine7Y12-MRGPRD-β-Alanine-Gi1/β1/γ2
3.03Single8YKDDehydroepiandrosterone8YKD-ADGRG2-Dehydroepiandrosterone-chim(NtGi1-Gs)/β1/γ2
2.94Single4K5YCP-3763954K5Y-CRF1-CP-376395
2.94Single4XNVBPTU4XNV-P2Y1-BPTU
2.94Single7VVOPTH7VVO-PTH1-PTH-Gs/β1/γ2
2.86Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
2.86Single8IYXYL-3658IYX-GPR34-YL-365
2.78Single4Z9GCP-3763954Z9G-CRF1-CP-376395
2.78Single8GTIBMK-C2058GTI-CRF1-BMK-C205
2.70Single8GTGBMK-I1528GTG-CRF1-BMK-I152
2.63Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Gi1/β1/γ1
2.56Single8GTMBMK-C2038GTM-CRF1-BMK-C203
2.38Single8XFTR-spondin-28XFT-LGR4-R-spondin-2-ZNRF3
2.38Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-ZNRF3
2.27Single8WVUR-spondin-18WVU-LGR4-R-spondin-1-RNF43
2.27Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-ZNRF3
2.22Single8XFPR-spondin-28XFP-LGR4-R-spondin-2-ZNRF3
2.08Single8XFSR-spondin-28XFS-LGR4-R-spondin-2-ZNRF3

Consensus Members
Id Members
etb_on_gp 8IY5-ETB-Endothelin-1-Gi1/β1/γ2
8HBD-ETB-IRL1620-Gi1/β1/γ2
eta_on_gp 8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
Net Summary
Imin 2.6625
Number of Linked Nodes 908
Number of Links 1110
Number of Hubs 177
Number of Links mediated by Hubs 680
Number of Communities 27
Number of Nodes involved in Communities 257
Number of Links involved in Communities 386
Path Summary
Number Of Nodes in MetaPath 92
Number Of Links MetaPath 91
Number of Shortest Paths 4439274
Length Of Smallest Path 3
Average Path Length 42.2304
Length of Longest Path 72
Minimum Path Strength 0.51875
Average Path Strength 5.37041
Maximum Path Strength 37.1212
Minimum Path Correlation 0.7025
Average Path Correlation 0.990082
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.66667
Average % Of Corr. Nodes 31.5191
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 51.2147
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following differences:
Id1st Network2nd Network
endothelin_off_on_gpendothelin_on_gpendothelin_off
This network is also present in following consensuses:
IdComponents
peptide_on_gpcck_on_gp
angiotensin_on_gp
apelin_on_gp
bombesin_on_gp
bradykinin_on_gp
compl-peptide_on_gp
endothelin_on_gp
formylpeptide_on_gp
galanin_on_gp
ghrelin_on_gp
kisspeptin_on_gp
melanocortin_on_gp
motilin_on_gp
neuromedin-u_on_gp
npy_on_gp
neurotensin_on_gp
opioid_on_gp
orexin_on_gp
relaxin_on_gp
somatostatin_on_gp
tachykinin_on_gp
trh_on_gp
vasop-oxy_on_gp



You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download endothelin_on_gp.zip



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You can also  read or  download a guide explaining the meaning of all files and numerical data.