Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
1G.HN.30 1.485407
2G.S1.02 5.3225425
3G.H1.01 6.98125429
4G.S2.08 7.4375425
5G.S3.01 4.66125424
6G.S3.03 6.78333627
7G.S3.04 8.476516
8G.S3.05 4.157527
9G.S3.06 8.25615
10G.s3h2.03 5.61625419
11G.H2.01 3.3725419
12G.H2.06 6.196519
13G.H2.07 6.34719
14G.H2.09 5.8825418
15G.h2s4.01 6.84417619
16G.h2s4.02 6.4375417
17G.S4.02 4.7775418
18G.S4.03 4.75125427
19G.S4.04 5.541559
20G.S4.05 3.76125427
21G.S4.07 7.09875428
22G.s4h3.04 6.292528
23G.H3.01 7.911509
24G.H3.09 6.25571759
25G.H3.13 6.257555
26G.H3.14 3.85125408
27G.H3.17 9.39167615
28G.H3.18 5.7375419
29G.S5.04 5.062559
30G.S5.05 4.59571729
31G.S5.07 4.335429
32G.s5hg.01 5.53125429
33G.HG.01 5.278555
34G.HG.04 5.14409
35G.HG.07 4.8175429
36G.HG.15 5.26625427
37G.hgh4.02 4.98527
38G.hgh4.05 7.15667627
39G.H4.03 7.18375454
40G.H4.07 5.10125455
41G.H4.08 3.8075453
42G.H4.10 7.945626
43G.H4.12 6.599555
44G.H4.15 7.9775458
45G.S6.02 6.945507
46G.S6.04 8.21429
47G.S6.05 6.362554
48G.s6h5.01 6.1525429
49G.s6h5.05 4.81375429
50G.H5.03 5.718528
51G.H5.08 7.745528
52G.H5.13 7.71875408
53b.1x3 1.9525401
54b.1x4 2.708508
55b.1x11 4.7725148
56b.h2x1 4.165505
57b.lhb1x6 4.2175403
58b.b1x6 8.63375409
59b.l1x3 9.3135129
60b.l1x6 11.485419
61b.b2x1 6.90333618
62b.b2x5 6.63643707
63b.b3x3 5.0625468
64b.l3x1 7.8525419
65b.l3x2 6.265409
66b.b4x2 5.0375408
67b.b4x3 6.5675467
68b.b4x5 4.63375467
69b.b4x6 10.41176129
70b.b4x7 7.43754138
71b.l4x2 10.4263404
72b.l4x3 5.75754136
73b.b5x2 7.334137
74b.b5x3 6.436676129
75b.b5x5 6.01875465
76b.b5x7 6.94407
77b.l5x1 5.30375468
78b.l5x5 8.60714719
79b.b6x5 5.55583666
80b.l6x5 6.32875414
81b.b7x1 6.221514
82b.b7x2 5.27125468
83b.b8x1 4.16375418
84b.b8x3 4.375516
85b.b8x4 6.11566
86b.l8x5 3.0675403
87b.b9x4 7.6025409
88b.l9x3 7.38519
89b.l9x6 5.71918
90b.l9x7 3.87875417
91b.b10x4 7.31375446
92b.b10x5 4.74786719
93b.l10x1 5.4075403
94b.b11x2 5.00875417
95b.b11x4 5.19583619
96b.l11x2 8.4775419
97b.b12x3 4.06448
98b.b12x5 4.305446
99b.b12x6 9.814518
100b.b13x3 6.76625414
101b.b13x7 8.865547
102b.l13x3 8.786549
103b.l13x6 5.842519
104b.l13x7 5.05875449
105b.b14x3 4.628545
106b.b15x1 7.954549
107b.b15x3 5.11449
108b.l15x1 5.72375417
109b.l15x2 6.55875449
110b.b16x4 12.2162446
111b.b16x5 6.6275405
112b.b16x6 8.8925648
113b.b16x7 6.256254169
114b.b17x3 5.41375445
115b.b17x7 8.8825418
116b.l17x3 8.39083619
117b.l17x6 8.3575419
118b.b18x3 3.36375418
119b.b18x5 5.842505
120b.l18x1 5.43786
121b.l18x3 6.74125485
122b.b19x2 7.76833616
123b.b19x4 6.82418
124b.l19x1 5.46125419
125b.l19x2 6.346519
126b.b20x2 5.37416
127b.b20x4 9.342518
128b.b20x6 7.978516
129b.b20x7 3.95509
130b.b21x1 6.556517
131b.b21x5 5.88125404
132b.b21x7 8.214505
133b.l21x2 6.85375404
134b.b22x5 4.89563887
135b.l22x5 7.84875409
136b.b23x2 5.485486
137b.b23x6 8607
138b.l23x1 7.50625416
139b.l24x2 4.58375406
140b.l24x3 4.0575405
141b.l25x3 9.022599
142b.l25x6 12.586518
143b.l27x1 10.2844819
144b.l27x2 6.94875499
145b.b28x3 4.93375407
146b.b28x4 9.91125496
147b.b28x5 4.81375405
148b.b28x6 8.88599
149g.h1x10 5.01875449
150g.h1x11 3.12875409
151g.h2x15 3.0325406
152g.ctx3 6.35756179
153g.ctx6 4.695406
1541x39 2.13407
1551x46 4.61375407
1561x60 3.4425406
1572x37 7.203754115
1582x40 6.88756119
1592x46 5.09875479
1602x50 5.647579
1612x57 7.42875437
1622x61 5.75833635
1632x64 6.34583634
1642x65 5.281534
1653x22 5.139176103
1663x33 4.91875436
1673x36 5.595407
1683x50 7.094579
169I2x53 6.943507
1704x50 5.4975409
171E2.W255 6.89875405
172E2.N256 4.1865106
173E2.F268 8.605435
174E2.H270 5.59754103
175E2.I271 4.38167633
1765x39 6.32286737
1775x43 7.70417636
1785x58 5.33417679
1795x60 9.6775194
1806x32 5.86125407
1816x48 4.833508
1826x51 3.9275437
1836x52 3.7475407
1846x55 4.43625436
185E3.K370 6.4575401
1867x34 4.84667634
1877x49 5.625479
1887x52 4.665479
1897x53 5.46679
1908x50 4.1955118
191Lig 6.95751630
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1b.b3x6 b.l1x3 20.884114.645NoYes099
2b.b3x6 b.l3x2 21.03088.1NoYes099
3b.b4x6 b.l1x3 18.76683.7YesYes1299
4b.l1x4 b.l3x2 23.5156.11NoYes069
5G.hns1.01 b.l1x4 24.2423.515NoNo036
6G.S1.03 G.hns1.01 24.388911.32NoNo093
7b.b10x1 b.b11x5 11.07323.26NoNo096
8b.b10x1 b.l9x6 11.16143.815NoYes098
9G.H2.07 b.l9x6 77.37145.79YesYes198
10G.H2.04 G.H2.07 89.95355NoYes099
11G.H2.04 G.H3.08 90.01726.68NoNo099
12G.H3.08 G.S4.04 90.0516.7NoYes099
13G.H3.09 G.S4.04 34.78310.72YesYes599
14G.H3.09 G.H4.15 34.52918.035YesYes598
15G.H3.06 G.H4.15 68.65049.21NoYes068
16G.H3.06 G.hgh4.02 68.12435.41NoYes067
17G.hgh4.01 G.hgh4.02 66.45235.06NoYes067
18G.hgh4.01 G.s4h3.04 66.27644.145NoYes068
19G.HG.07 G.s4h3.04 1007.76YesYes298
20G.HG.03 G.HG.07 99.81724.23NoYes269
21G.HG.03 G.s5hg.01 98.12554.935NoYes269
22G.S5.07 G.s5hg.01 96.82193.5YesYes299
23G.H1.04 G.S5.07 14.05985.665NoYes279
24G.H1.04 G.S5.05 14.16614.395NoYes279
25G.S4.03 G.S5.05 30.02933.765YesYes279
26G.S1.04 G.S4.03 27.47547.85NoYes277
27G.S1.04 G.S3.03 27.23883.65NoYes277
28G.S1.02 G.S3.03 11.57457.33YesYes257
29G.S4.04 G.S5.04 68.82844.26YesYes599
30G.H4.15 G.S5.04 34.29245.485YesYes589
31G.S5.04 G.S5.06 34.16656.92YesNo098
32G.S5.06 G.S6.05 34.11766.7NoYes084
33G.HG.01 G.S6.05 33.59546.475YesYes554
34G.HG.01 G.HG.04 33.53493.325YesYes059
35G.HG.04 G.s4h3.04 33.47824.855YesYes098
36G.S5.07 G.s6h5.01 80.78274.385YesYes299
37G.S5.05 G.s6h5.01 13.93935.835YesYes299
38G.S3.01 G.S3.03 11.29835.665YesYes247
39G.S1.03 G.S3.06 24.47064.705NoYes195
40G.S3.06 G.h2s4.01 25.70483.755YesYes159
41G.S1.05 G.h2s4.01 13.136515.225NoYes199
42G.S1.05 G.S1.07 13.12716.23NoNo199
43G.H3.12 G.S1.07 13.49873.565NoNo089
44G.S1.02 I2x51 11.02593.855YesNo257
45G.S3.01 I2x51 11.03645.005YesNo247
46G.H2.06 b.l9x6 66.07483.58YesYes198
47G.H2.06 b.l19x1 65.96693.455YesYes199
48G.S6.04 G.s6h5.01 65.93143.425YesYes299
49G.H5.10 G.S6.04 67.31185.675NoYes069
50G.H5.10 G.S6.02 68.963310.715NoYes067
51G.H5.13 G.S6.02 67.21489.77YesYes087
52G.H5.13 G.H5.17 65.2076.8YesNo085
53G.H5.15 I2x51 21.51183.565NoNo077
546x29 G.H5.17 65.08833.6NoNo065
55G.H5.15 G.H5.19 20.41052.835NoNo078
56G.H5.19 I2x53 19.85986.395NoYes087
572x37 G.H5.22 11.04164.17YesNo054
58G.H5.22 I2x53 11.59314.025NoYes047
593x50 G.H5.25 63.55297.29YesNo097
606x32 G.H5.25 63.67214.64YesNo077
616x32 G.H5.26 64.14326.995YesNo075
626x29 G.H5.26 64.26224.355NoNo065
63b.l17x5 b.l19x1 66.21843.68NoYes169
64b.b19x6 b.l17x5 26.76364.075NoNo196
65b.b19x6 b.l17x3 26.698911.155NoYes199
66b.b19x4 b.l17x3 28.118710.265YesYes189
67b.b19x4 b.b20x6 24.09477.135YesYes186
68b.b17x7 b.b20x6 54.420810.715YesYes186
69b.b17x7 b.b21x1 49.46714.775YesYes187
70b.1x19 b.b21x1 47.27739.53NoYes067
71b.1x15 b.1x19 12.10516.89NoNo076
72b.1x15 g.h1x11 11.71354.995NoYes079
73b.l17x5 b.l19x2 39.40833.68NoYes169
74b.l17x3 b.l19x2 26.7135.67YesYes199
75b.b20x4 b.l17x3 24.69811.85YesYes189
76b.b20x4 b.b20x6 36.13614.275YesYes186
77b.b20x2 b.l19x2 12.57987.225YesYes169
78b.b20x2 b.b20x4 12.35987.115YesYes168
79b.1x19 b.b21x2 35.12164.67NoNo066
80b.b3x2 b.b4x6 15.72856.83NoYes059
81b.b2x5 b.b3x2 15.583811.39YesNo075
82b.b2x5 b.l26x1 15.383412.13YesNo077
83b.l26x1 b.l26x3 15.08967.225NoNo1577
84b.l26x3 b.l26x5 14.95359.01NoNo075
85b.l26x5 g.ctx4 14.81316.71NoNo057
86g.ctx3 g.ctx4 14.134.025YesNo097
87g.ctx3 g.ctx6 11.99448.82YesYes096
88b.l22x5 g.ctx6 10.74784.86YesYes096
89b.b22x5 b.b23x2 10.58189.745YesYes876
90b.l18x1 b.l18x3 29.4996.645YesYes865
91b.l18x3 b.l18x5 32.471311.58YesNo052
92b.l18x5 b.l20x2 32.845415.665NoNo029
93b.b21x2 g.l1x5 33.97674.805NoNo064
94b.b21x7 b.b24x6 12.491414.47YesNo058
952x64 Lig 22.122314.115YesYes340
963x36 Lig 25.62965.375YesYes070
973x36 3x39 26.93363.305YesNo079
982x50 3x39 27.19514.42YesNo099
992x46 2x50 17.68716.105YesYes799
1002x46 3x43 19.34484.845YesNo798
1013x43 7x53 60.54255.275NoYes789
1023x50 7x53 61.22756.685YesYes799
1032x50 7x49 17.653.365YesYes799
1043x43 7x49 41.0774.12NoYes789
1055x43 Lig 12.804615.34YesYes360
1065x43 6x48 17.6893.28YesYes068
1076x48 7x45 22.84976.215YesNo089
1087x45 7x49 23.36611.58NoYes099
1092x64 E1.D184 10.87853.585YesNo042
110G.H3.12 G.S4.04 13.55883.765NoYes089
111G.H2.07 G.h2s4.01 14.4144.51YesYes199
112b.l20x2 g.l1x5 33.59823.13NoNo094
113b.b22x5 b.l18x1 21.85068.575YesYes876
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
2x64NT.F1084.8253YesNo4012
E1.H181NT.M1093.283NoNo0022
2x65NT.L1113.2153YesNo4012
1x352x613.773NoYes5521
1x357x393.6453NoNo5522
2x563x323.070NoNo5721
2x572x6110.7153YesYes7511
2x577x384.623YesNo7611
2x577x424.2653YesNo7712
2x57Lig10.1153YesYes7010
2x603x284.590NoNo4612
2x60Lig4.720NoYes4010
2x612x657.923YesYes5411
2x617x385.9453YesNo5611
2x617x393.113YesNo5512
2x61Lig3.093YesYes5010
2x642x657.353YesYes4411
2x64E1.H1815.093YesNo4012
2x64Lig14.1153YesYes4010
2x65Lig6.4553YesYes4010
3x29E2.F2684.2653NoYes4011
3x29E2.I2713.573NoYes4011
3x29Lig6.3653NoYes4010
3x32Lig5.4550NoYes7010
3x335x436.0653YesYes6611
3x33Lig9.23YesYes6010
3x353x364.620NoYes7721
3x363x393.3050YesNo7912
3x367x419.080YesNo7712
3x36Lig5.3750YesYes7010
3x375x438.490NoYes6621
4x565x393.0253NoYes5721
4x565x428.163NoNo5622
4x605x399.040NoYes6721
5x39E2.W25513.023YesYes7012
E2.F268E2.I2679.423YesNo0012
7x34E2.I2678.163YesNo4012
E2.F268E2.I2717.5353YesYes0011
E2.F268Lig13.23YesYes0010
5x39E2.I2716.653YesYes7011
5x40E2.I2713.570NoYes5021
E2.I271Lig3.4153YesYes0010
5x395x423.613YesNo7612
5x395x433.8553YesYes7611
5x39Lig5.063YesYes7010
5x435x479.1953YesNo6812
5x436x483.283YesYes6812
5x43Lig15.343YesYes6010
5x446x557.290NoYes5621
6x486x514.5550YesYes8722
6x516x553.5353YesYes7621
6x517x343.6553YesYes7421
6x517x413.9653YesNo7722
6x547x347.5350NoYes4421
6x557x343.7353YesYes6411
7x34Lig3.23YesYes4010
7x38Lig3.033NoYes6010
2x64NT.M1093.113YesNo4012
2x64E1.D1843.5853YesNo4012
6x55Lig3.1853YesYes6010
7x347x372.7953YesNo4512
3x303x332.730NoYes6621
3x334x571.683YesNo6712
E2.I271E2.S2651.553YesNo0012
2x657x351.4653YesNo4412

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
93.33Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
93.33Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
93.33Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
86.67Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
82.35Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
80.00Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
80.00Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
80.00Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
80.00Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
77.78Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
76.47Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
75.00Single5XR8AM8415XR8-CB1-AM841
75.00Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
75.00Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
75.00Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
73.33Single7V3ZCP559407V3Z-CB1-CP55940
72.22Single5ZTYAM102575ZTY-CB2-AM10257
72.22Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
70.59Single6KQICP559406KQI-CB1-CP55940-Org27569
68.75Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
66.67Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
66.67Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
66.67Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
66.67Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
64.71Single5XRAAM115425XRA-CB1-AM11542
64.71Single7FEECP559407FEE-CB1-CP55940-ZCZ011
64.71Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
64.71Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
62.50Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
61.11Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
61.11Single9DGIZ85267113509DGI-CB1-Z8526711350
61.11Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
61.11Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
58.82Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
58.82Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
56.25Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
56.25Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
55.56Single9EGOYVF9EGO-CB1-YVF-Gi1/β1/γ2
54.55Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
52.63Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
52.63Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
52.38Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
52.38Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
52.00Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
50.00Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
50.00Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
50.00Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
50.00Single9I52A1IZU9I52-D1-A1IZU-Gs/β1/γ2
50.00Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
50.00Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
50.00Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
47.83Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
47.62Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
47.62Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
47.62Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
47.37Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
47.37Single8E0GBU728E0G-μ-BU72
47.06Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
47.06Single9M2FNeuropeptide FF9M2F-NPFF1-Neuropeptide FF-Gi1/β1/γ2
45.83Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
45.45Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
45.45Consensuslpl_onOrthosteric Ligands1p_on lpa_on
45.45Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
45.00Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
45.00Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
45.00Single7YITNalfurafine7YIT-κ-Nalfurafine
45.00Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
45.00Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
45.00Consensuslpl_offOrthosteric Ligands1p_off lpa_off
45.00Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
45.00Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
45.00Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
44.44Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
44.44Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
44.44Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
44.44Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
44.44Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
44.44Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
44.44Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
44.00Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
44.00Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
44.00Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
43.48Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
43.48Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
43.48Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
42.86Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
42.86Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
42.86Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
42.86Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
42.31Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
42.31Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
42.11Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
42.11Single5C1MBU725C1M-μ-BU72
42.11Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
42.11Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
42.11Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
42.11Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
42.11Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
42.11Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
42.11Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
42.11Single8JXSPF-61428JXS-D1-PF-6142
42.11Single8TF5Oleic acid8TF5-GPR6-Oleic acid
42.11Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
42.11Single9KPFSA09KPF-TAS2R16-SA0-Gi1/β1/γ2
42.11Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
42.11Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
41.67Single6W25SHU91196W25-MC4-SHU9119-Ca
41.67Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
41.67Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
41.67Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
41.67Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
41.18Single6AKXA4R6AKX-CCR5-A4R
41.18Single6B73MP11046B73-κ-MP1104
41.18Single8YYWAlpha-ketoglutarate8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
41.18Single9K6LSA09K6L-TAS2R16-SA0-Gi2/β1/γ2
41.18Consensusorexin_offOrthosteric Ligandox2_off ox1_off
41.18Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
40.91Single4UG2CGS216804UG2-A2A-CGS21680
40.91Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
40.91Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
40.91Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
40.91Single8Y72Peptide8Y72-μ-Peptide-BMS-986122-Gi1/β1/γ2
40.91Single9M0RNeuropeptide VF9M0R-NPFF1-Neuropeptide VF-Gi1/β1/γ2
40.91Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
40.91Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
40.91Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
40.74Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
40.74Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
40.74Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
40.74Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
40.74Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
40.00Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
40.00Single4DJHJDTic4DJH-κ-JDTic
40.00Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
40.00Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
40.00Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
40.00Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
40.00Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
40.00Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
40.00Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
40.00Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
40.00Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
40.00Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
40.00Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
40.00Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
40.00Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
40.00Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
40.00Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
40.00Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
40.00Single8Y73Peptide8Y73-μ-Peptide-MPAM-15-Gi1/β1/γ2
40.00Single8ZBISomatostatin-148ZBI-SST3-Somatostatin-14-Gi1/β1/γ2
40.00Single9I54A1IZV9I54-D1-A1IZV-Gs/β1/γ2
40.00Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
40.00Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
40.00Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
40.00Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
40.00Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
40.00Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
40.00Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
40.00Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
40.00Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
39.13Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
39.13Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
38.89Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
38.89Single4MBSMaraviroc4MBS-CCR5-Maraviroc
38.89Single4ZJCSB-6740424ZJC-OX1-SB-674042
38.89Single6TPGEMPA6TPG-OX2-EMPA
38.89Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
38.89Single8K5CAcipimox8K5C-HCA2-Acipimox
38.89Single8K9LDamgo8K9L-μ-Damgo-BMS-986122-Gi3/β1/γ1
38.89Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
38.89Single9KPDSA09KPD-TAS2R16-SA0-chim(Gs-CtGt3)/β1/γ2
38.89Consensushca_onOrthosteric Ligandhca2_on
38.46Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
38.46Single8ZRTET-18ZRT-ETB-ET-1
38.46Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
38.46Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
38.10Single4RWADIPP-NH24RWA-δ-DIPP-NH2
38.10Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
38.10Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
38.10Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
38.10Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
38.10Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
38.10Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
38.10Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
38.10Single9M4QDoxazosin9M4Q-Alpha1A-Doxazosin
38.10Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
38.10Consensusalpha1_offOrthosteric Ligandalpha1a_off
38.10Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
38.10Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
38.10Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
38.10Consensuslpa_offOrthosteric Ligandlpa1_off
38.10Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
38.10Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
38.10Consensusorexin_onOrthosteric Ligandox2_on
38.10Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
37.50Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
37.50Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
37.50Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
37.50Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
37.50Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
37.50Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
37.50Consensus5ht2_onOrthosteric Ligand5ht2b_on
37.50Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
37.50Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
37.50Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
37.50Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
37.50Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
37.50Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
37.04Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
37.04Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
36.84Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
36.84Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
36.84Single6TOTLemborexant6TOT-OX1-Lemborexant
36.84Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
36.84Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
36.84Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
36.84Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
36.84Single7UL4Alvimopan7UL4-μ-Alvimopan
36.84Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
36.84Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
36.84Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
36.84Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
36.84Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
36.84Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
36.84Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
36.84Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
36.84Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
36.84Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
36.84Single9CHXS-Carazolol9CHX-β2-S-Carazolol
36.84Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
36.84Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
36.84Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
36.84Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
36.84Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
36.84Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
36.84Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
36.84Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
36.84Consensushca_on_gpOrthosteric Ligandhca2_on_gp
36.67Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
36.67Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
36.36Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
36.36Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
36.36Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
36.36Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
36.36Single5X93K-87945X93-ETB-K-8794
36.36Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
36.36Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
36.36Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
36.36Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
36.36Single7UM4AS26747237UM4-5-HT5A-AS2674723
36.36Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
36.36Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
36.36Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
36.36Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
36.36Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
36.36Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
36.36Single8ZWGJR14a8ZWG-C3aB-JR14a-Gi1/β1/γ2
36.36Single9M54Neuropeptide VF9M54-NPFF2-Neuropeptide VF-Gi1/β1/γ2
36.36Consensusendothelin_offOrthosteric Ligandetb_off
36.36Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
36.36Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
36.36Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
36.36Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
36.36Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
36.36Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
36.36Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
36.36Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
36.00Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
36.00Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
36.00Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
36.00Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
36.00Single9U4WGonadoliberin-19U4W-GnRH1-Gonadoliberin-1-chim(NtGi1L-Gs-CtGq)/β1/γ2
36.00Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
36.00Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
36.00Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
35.71Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
35.71Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
35.71Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
35.71Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
35.71Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
35.71Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
35.71Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
35.48Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
35.29Single7XP6Strychnine7XP6-TAS2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
35.29Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
35.29Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
35.29Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
35.29Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
35.29Single8K5BNiacin8K5B-HCA2-Niacin
35.29Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
35.29Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
35.29Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
35.29Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
35.00Single2YCWS-Carazolol2YCW-β1-S-Carazolol
35.00Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
35.00Single5D6LS-Carazolol5D6L-β2-S-Carazolol
35.00Single5TVNLSD5TVN-5-HT2B-LSD
35.00Single5WQCEMPA5WQC-OX2-EMPA
35.00Single5XPRBosentan5XPR-ETB-Bosentan
35.00Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
35.00Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
35.00Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
35.00Single6TP6Filorexant6TP6-OX1-Filorexant
35.00Single7C4SS1P7C4S-S1P3-S1P
35.00Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
35.00Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
35.00Single7LD3Adenosine7LD3-A1-Adenosine-MIPS521-Gi2/β1/γ2
35.00Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
35.00Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
35.00Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
35.00Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
35.00Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
35.00Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
35.00Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
35.00Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
35.00Single8S4DCMF-0198S4D-Apelin-CMF-019
35.00Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
35.00Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
35.00Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
35.00Single9CIBFCH-22964139CIB-HCA2-FCH-2296413
35.00Single9EHSLUF76029EHS-A3A-LUF7602
35.00Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
35.00Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
35.00Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
35.00Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
34.78Single3NY9ICI118-5513NY9-β2-ICI118-551
34.78Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
34.78Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
34.78Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
34.78Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
34.78Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
34.78Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
34.78Single8QJ2pN1628QJ2-MC4-pN162-Gs
34.78Single9IPVJR14a9IPV-C3aB-JR14a-Gi1/β1/γ2
34.78Single9V2NMacimorelin9V2N-Ghrelin-Macimorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
34.62Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
34.62Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
34.62Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
34.62Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
34.62Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
34.62Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
34.62Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
34.62Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
34.48Single6IGLIRL16206IGL-ETB-IRL1620
34.48Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
34.48Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
34.48Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
34.38Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
33.33Single2YDVNECA2YDV-A2A-NECA
33.33Single3P0GBI1671073P0G-β2-BI167107
33.33Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
33.33Single4UHRCGS216804UHR-A2A-CGS21680
33.33Single4XT1Fractalkine4XT1-US28-Fractalkine
33.33Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
33.33Single5D5AS-Carazolol5D5A-β2-S-Carazolol
33.33Single5D5BS-Carazolol5D5B-β2-S-Carazolol
33.33Single5G53NECA5G53-A2A-NECA-Gs
33.33Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
33.33Single5WS3EMPA5WS3-OX2-EMPA
33.33Single6AKYMaraviroc6AKY-CCR5-Maraviroc
33.33Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
33.33Single6H7JIsoprenaline6H7J-β1-Isoprenaline
33.33Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
33.33Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
33.33Single6TODEMPA6TOD-OX1-EMPA-Na
33.33Single6TQ7SB-3348676TQ7-OX1-SB-334867
33.33Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
33.33Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
33.33Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
33.33Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
33.33Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
33.33Single7QA8Peptide7QA8-STE2-Peptide
33.33Single7QA8Peptide7QA8-STE2-Peptide
33.33Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
33.33Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
33.33Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
33.33Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
33.33Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
33.33Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
33.33Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
33.33Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
33.33Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
33.33Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
33.33Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
33.33Single7XRRLemborexant7XRR-OX2-Lemborexant
33.33Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
33.33Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
33.33Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
33.33Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
33.33Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
33.33Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
33.33Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
33.33Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
33.33Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
33.33Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
33.33Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
33.33Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
33.33Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
33.33Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
33.33Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
33.33Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
33.33Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
33.33Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
33.33Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
33.33Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
33.33Single8KIGSHU91198KIG-MC3-SHU9119-Ca
33.33Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
33.33Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
33.33Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
33.33Single8WDTphotoNECA8WDT-A2A-photoNECA
33.33Single8WKYPG-9348WKY-MC4-PG-934
33.33Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
33.33Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
33.33Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
33.33Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
33.33Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
33.33Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
33.33Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
33.33Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
33.33Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
33.33Single9BJKNaloxone9BJK-μ-Naloxone-NAM
33.33Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single9BUYLM1899BUY-β2-LM189-Gi1/β1/γ2
33.33Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
33.33Single9IK9SST analogue9IK9-SST1-SST analogue-Gi1/β1/γ2
33.33Single9JFYhNPSF9JFY-NPFF2-hNPSF-Gi1/β1/γ2
33.33Single9JMCDS-3801b9JMC-Motilin-DS-3801b-chim(Gs-CtGq)/β1/γ2
33.33Single9KPESA09KPE-TAS2R16-SA0-Gi1/β1/γ2
33.33Single9UY3Anamorelin9UY3-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
33.33Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
33.33Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
33.33Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
33.33Consensusa2_onOrthosteric Liganda2b_on
33.33Consensusa2_on_gpOrthosteric Liganda2b_on_gp
33.33Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
33.33Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
33.33Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
33.33Consensusclass-a_class-b1_cons_onOrthosteric Ligandclass-a_on class-b1_on
33.33Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
33.33Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
33.33Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
33.33Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
33.33Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
33.33Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
33.33Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
33.33Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
33.33Consensuslpa_onOrthosteric Ligandlpa1_on
33.33Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
33.33Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
33.33Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
33.33Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
33.33Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
33.33Consensuspth_onOrthosteric Ligandpth1_on pth2_on
33.33Consensuspth_on_gpOrthosteric Ligandpth1_on_gp pth2_on_gp
33.33Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
33.33Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
33.33Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
33.33Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
32.26Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
32.14Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
32.14Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
32.14Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
32.14Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
32.14Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
32.00Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
32.00Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
32.00Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
32.00Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
32.00Single9IK8SST analogue9IK8-SST1-SST analogue-Gi1/β1/γ2
32.00Single9J0FNADH9J0F-P2Y14-NADH-Gi1/β1/γ2
32.00Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
32.00Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
32.00Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
32.00Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
32.00Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
32.00Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
31.82Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
31.82Single3D4STimolol3D4S-β2-Timolol
31.82Single4LDEBI1671074LDE-β2-BI167107
31.82Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
31.82Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
31.82Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
31.82Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
31.82Single6MXTSalmeterol6MXT-β2-Salmeterol
31.82Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
31.82Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
31.82Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
31.82Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
31.82Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
31.82Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
31.82Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
31.82Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
31.82Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
31.82Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
31.82Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
31.82Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
31.82Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
31.82Single8JJ8Formoterol8JJ8-β2-Formoterol
31.82Single8JJLOlodaterol8JJL-β2-Olodaterol
31.82Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
31.82Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
31.82Single8XJNCloprosetnol8XJN-TXA2-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
31.82Single8XYIVUF106618XYI-CXCR3-VUF10661
31.82Single9GGGI-BOP9GGG-TXA2-I-BOP-chim(NtGi2L-Gs-CtGq)/β1/γ2
31.82Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
31.82Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
31.82Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
31.82Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
31.82Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
31.82Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
31.58Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
31.58Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
31.58Single6PS0S-Carazolol6PS0-β2-S-Carazolol
31.58Single6PS4ICI118-5516PS4-β2-ICI118-551
31.58Single6PS5S-Propranolol6PS5-β2-S-Propranolol
31.58Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
31.58Single6TPNHTL66416TPN-OX2-HTL6641
31.58Single6VI4JDTic6VI4-κ-JDTic
31.58Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
31.58Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
31.58Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
31.58Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
31.58Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
31.58Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
31.58Single7F61PF-036547467F61-H3-PF-03654746
31.58Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
31.58Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
31.58Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
31.58Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.58Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
31.58Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
31.58Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
31.58Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
31.58Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
31.58Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
31.58Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
31.58Single8IHKAcifran8IHK-HCA3-Acifran
31.58Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
31.58Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
31.58Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
31.58Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
31.58Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
31.58Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
31.58Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.58Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.58Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
31.58Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
31.58Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
31.58Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
31.58Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
31.58Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
31.58Single9JMDAzithromycin9JMD-Motilin-Azithromycin-chim(Gs-CtGq)/β1/γ2
31.58Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
31.58Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
31.58Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
31.58Consensusalpha1_onOrthosteric Ligandalpha1a_on
31.58Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
31.58Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
31.58Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
31.58Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
31.58Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
31.58Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
31.58Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
31.43Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
31.25Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
31.25Consensuscrf_on_gpOrthosteric Ligandcrf2_on_gp crf1_on_gp
31.03Single8W8WAlpha-MSH8W8W-MC3-α-MSH-Ca-Gs/β1/γ2
31.03Single8W8XBeta-MSH8W8X-MC3-β-MSH-Ca-Gs/β1/γ2
31.03Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
31.03Single9KDFRES-701-39KDF-ETB-RES-701-3
31.03Consensusglp_onOrthosteric Ligandglp1_on glp2_on
31.03Consensusglp_on_gpOrthosteric Ligandglp1_on_gp glp2_on_gp
31.03Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
30.77Single6PT2KGCHM076PT2-δ-KGCHM07
30.77Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
30.77Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
30.77Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
30.77Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
30.77Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
30.77Single8W8YGamma-MSH8W8Y-MC3-γ-MSH-Ca-Gs/β1/γ2
30.77Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
30.77Consensusangiotensin_onOrthosteric Ligandat1_on
30.77Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
30.77Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
30.77Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
30.77Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
30.43Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
30.43Single6K1QIRL25006K1Q-ETB-IRL2500
30.43Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
30.43Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
30.43Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
30.43Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
30.43Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
30.43Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
30.43Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
30.43Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
30.43Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
30.43Single8S2TIsoprenaline8S2T-β1-Isoprenaline-chim(NtGi1-Gs)/β1/γ2
30.43Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
30.43Single8XJOU466198XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
30.43Single8XVJMacitentan8XVJ-ETA-Macitentan
30.43Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
30.43Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
30.43Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
30.43Consensuscck_onOrthosteric Ligandccka_on cckb_on
30.43Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
30.43Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
30.43Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
30.43Consensustp_onOrthosteric Ligand8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
30.43Consensustp_on_gpOrthosteric Ligand8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
30.30Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
30.30Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
30.30Consensusclass-a_class-b1_cons_on_gpOrthosteric Ligandclass-a_on_gp class-b1_on_gp
30.00Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
30.00Single2Y04Salbutamol2Y04-β1-Salbutamol
30.00Single3NY8ICI118-5513NY8-β2-ICI118-551
30.00Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
30.00Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
30.00Single4EJ4Naltrindole4EJ4-δ-Naltrindole
30.00Single4GBRS-Carazolol4GBR-β2-S-Carazolol
30.00Single4YAYZD-71554YAY-AT1-ZD-7155
30.00Single5DHGC-355DHG-NOP-C-35
30.00Single5DHHSB-6121115DHH-NOP-SB-612111
30.00Single6DRXLisuride6DRX-5-HT2B-Lisuride
30.00Single6IIVDaltroban6IIV-TXA2-Daltroban
30.00Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
30.00Single6PS1Timolol6PS1-β2-Timolol
30.00Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
30.00Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
30.00Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
30.00Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
30.00Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
30.00Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
30.00Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
30.00Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
30.00Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
30.00Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
30.00Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
30.00Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
30.00Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
30.00Single7YXAONO-54306087YXA-S1P5-ONO-5430608
30.00Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
30.00Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
30.00Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
30.00Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
30.00Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
30.00Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
30.00Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
30.00Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
30.00Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.00Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.00Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.00Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.00Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.00Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.00Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.00Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.00Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.00Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.00Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
30.00Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
30.00Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
30.00Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
30.00Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
30.00Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
30.00Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
30.00Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
30.00Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
30.00Single8JXRLSD8JXR-D1-LSD
30.00Single8K5DGSK2560738K5D-HCA2-GSK256073
30.00Single8PJKST1718PJK-5-HT1A-ST171-Gi1/β1/γ1
30.00Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
30.00Single8T1WCVN4248T1W-GPR6-CVN424
30.00Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
30.00Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
30.00Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.00Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.00Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.00Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.00Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
30.00Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
30.00Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
30.00Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
30.00Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
30.00Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
30.00Single9IZCMK19039IZC-HCA2-MK1903-Gi1/β1/γ2
30.00Single9KFJPubChem 1383196749KFJ-RXFP3-PubChem 138319674-Gi2/β1/γ2
30.00Single9PLNN-(5-methylnaphthalen-1-yl)pyridin-4-amine9PLN-α2a-N-(5-methylnaphthalen-1-yl)pyridin-4-amine
30.00Single9PLON-(5-methylnaphthalen-1-yl)pyridin-4-amine9PLO-α2a-N-(5-methylnaphthalen-1-yl)pyridin-4-amine-Go/β1/γ2
30.00Single9PQD(6m)-1-methyl-6-(1,2,5,6-tetrahydropyridin-3-yl)-1h-indole9PQD-α2a-(6m)-1-methyl-6-(1,2,5,6-tetrahydropyridin-3-yl)-1h-indole
30.00Consensus5ht5_onOrthosteric Ligand5ht5a_on
30.00Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
30.00Consensusa3_onOrthosteric Liganda3a_on
30.00Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
30.00Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
30.00Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
30.00Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
30.00Consensusblt_onOrthosteric Ligandblt1_on
30.00Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
30.00Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
30.00Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
30.00Consensusdopamine_offOrthosteric Ligandd2_off d3_off
30.00Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
30.00Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
30.00Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
30.00Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
30.00Consensusleukotriene_onOrthosteric Ligandblt_on
30.00Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
29.63Single6JODAngiotensin II6JOD-AT2-Angiotensin II
29.63Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
29.63Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
29.63Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
29.63Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
29.63Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
29.63Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
29.63Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
29.63Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
29.63Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
29.63Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
29.63Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
29.63Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
29.63Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
29.63Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
29.63Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
29.63Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
29.41Single3OE6IT1t3OE6-CXCR4-IT1t
29.41Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
29.41Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
29.41Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.41Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
29.41Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
29.41Consensusglucagon_on_gpOrthosteric Ligandglp_on_gp gluc_on_gp secretin_on_gp gip_on_gp
29.17Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
29.17Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
29.17Single6PT3DPI-2876PT3-δ-DPI-287
29.17Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
29.17Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
29.17Single7SK9CCX6627SK9-ACKR3-CCX662
29.17Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
29.17Single7XN9L-054,5227XN9-SST2-L-054,522
29.17Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
29.17Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
29.17Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
29.17Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
29.17Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
29.17Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
29.17Single8X5YAstemizole8X5Y-H1-Astemizole
29.17Single9CGKC5-Quino9CGK-δ-C5-Quino-Gi1/β1/γ2
29.17Single9IPYJR14a9IPY-C3aB-JR14a
29.17Single9IZASCH9002719IZA-HCA2-SCH900271-Gi1/β1/γ2
29.17Single9JH6C20:0 Ceramide9JH6-CysLT2-C20:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
29.17Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
29.17Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
29.17Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
29.17Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
29.17Consensuskisspeptin_onOrthosteric Ligandkiss1_on
29.03Single5GLHEndothelin-15GLH-ETB-Endothelin-1
29.03Single6IGKEndothelin-36IGK-ETB-Endothelin-3
29.03Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
29.03Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
29.03Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
29.03Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
29.03Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
29.03Consensusbombesin_onOrthosteric Ligandbb2_on
29.03Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
29.03Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
29.03Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
28.57Single2RH1S-Carazolol2RH1-β2-S-Carazolol
28.57Single2Y03Isoprenaline2Y03-β1-Isoprenaline
28.57Single5JQHS-Carazolol5JQH-β2-S-Carazolol
28.57Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
28.57Single5X7DS-Carazolol5X7D-β2-S-Carazolol-Cmpd-15
28.57Single6E67BI1671076E67-β2-BI167107-Gs(CT)
28.57Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
28.57Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
28.57Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
28.57Single6PS6Timolol6PS6-β2-Timolol
28.57Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
28.57Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
28.57Single7C61Ergotamine7C61-5-HT1B-Ergotamine
28.57Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
28.57Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
28.57Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
28.57Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
28.57Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
28.57Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
28.57Single7W41PD1762527W41-BB2-PD176252
28.57Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
28.57Single7WC6LSD7WC6-5-HT2A-LSD
28.57Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
28.57Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
28.57Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
28.57Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
28.57Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
28.57Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
28.57Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
28.57Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
28.57Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
28.57Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
28.57Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
28.57Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
28.57Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
28.57Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
28.57Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
28.57Single8WGBVU01550418WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
28.57Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
28.57Single8XYKVUF106618XYK-CXCR3-VUF10661-Go/β1/γ2
28.57Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
28.57Single8ZVZBW245C8ZVZ-DP1-BW245C-Gs/β1/γ2
28.57Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
28.57Single9EE8Adenosine9EE8-A2A-Adenosine-Gs/β1/γ2
28.57Single9F33FOB02-04A9F33-D3-FOB02-04A-Go/β1/γ2
28.57Single9GE2ML1849GE2-GPR55-ML184-chim(NtGi1-G13)/β1/γ2
28.57Single9HAPTolvaptan9HAP-V2-Tolvaptan
28.57Single9K07DSO-5a9K07-BB3-DSO-5a-chim(NtGi2L-Gs-CtGq)/β1/γ2
28.57Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
28.57Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
28.57Consensusa3_on_gpOrthosteric Liganda3a_on_gp
28.57Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
28.57Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
28.57Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
28.57Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
28.57Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
28.57Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
28.57Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
28.57Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
28.57Consensusamine_offonOrthosteric Ligandamine_off amine_on
28.57Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
28.57Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
28.57Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
28.57Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
28.57Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
28.57Consensusbombesin_offOrthosteric Ligandbb2_off
28.57Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
28.57Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
28.57Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
28.57Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
28.57Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
28.57Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
28.57Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
28.57Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
28.57Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
28.57Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
28.57Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
28.57Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
28.57Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
28.57Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
28.57Consensustrace-amine_onOrthosteric Ligandta1_on
28.12Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
28.12Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
28.00Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
28.00Single4IARErgotamine4IAR-5-HT1B-Ergotamine
28.00Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
28.00Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
28.00Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
28.00Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
28.00Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
28.00Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
28.00Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
28.00Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
28.00Single8PKMBefiradol8PKM-5-HT1A-Befiradol-Gi1/β1/γ1
28.00Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
28.00Single8ZBJSomatostatin-148ZBJ-SST5-Somatostatin-14-Gi1/β1/γ2
28.00Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
28.00Single9HB3Mambaquaretin-19HB3-V2-Mambaquaretin-1
28.00Single9J0IUDP-Glucuronic acid9J0I-P2Y14-UDP-Glucuronic acid-Gi1/β1/γ2
28.00Single9M4TSilodosin9M4T-Alpha1A-Silodosin
28.00Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
28.00Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
28.00Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
28.00Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
28.00Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
28.00Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
28.00Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
28.00Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
28.00Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
28.00Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
28.00Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
28.00Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
28.00Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
27.78Single3OE9IT1t3OE9-CXCR4-IT1t
27.78Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
27.78Single7SRQLSD7SRQ-5-HT2B-LSD
27.78Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
27.78Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
27.78Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
27.78Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
27.78Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
27.78Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
27.78Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
27.78Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
27.78Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
27.78Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
27.78Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
27.78Single9IXJHistamine9IXJ-H2-Histamine-Gs/β1/γ2
27.78Single9IZDCHBA9IZD-HCA1-CHBA-Gi1/β1/γ2
27.78Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
27.59Single4XT3Fractalkine4XT3-US28-Fractalkine
27.59Single6FJ3PTH6FJ3-PTH1-PTH
27.59Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
27.59Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
27.59Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
27.59Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
27.59Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
27.59Single9KFKRelaxin-39KFK-RXFP4-Relaxin-3-Gi2/β1/γ2
27.59Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
27.59Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
27.59Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
27.27Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
27.27Single6J21Aprepitant6J21-NK1-Aprepitant
27.27Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
27.27Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
27.27Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
27.27Single6WGTLSD6WGT-5-HT2A-LSD
27.27Single7B6WCyclazosin7B6W-α1b-Cyclazosin
27.27Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
27.27Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
27.27Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
27.27Single7TUYGSK682753A7TUY-GPR183-GSK682753A
27.27Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
27.27Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
27.27Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
27.27Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
27.27Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
27.27Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
27.27Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
27.27Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
27.27Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
27.27Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
27.27Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
27.27Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
27.27Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
27.27Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
27.27Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
27.27Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
27.27Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
27.27Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
27.27Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
27.27Single8XVLZibotentan8XVL-ETA-Zibotentan
27.27Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
27.27Single8ZW0PGD28ZW0-DP1-PGD2-Gs/β1/γ2
27.27Single8ZWFJR14a8ZWF-C3aB-JR14a
27.27Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
27.27Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
27.27Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
27.27Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
27.27Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
27.27Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
27.27Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
27.27Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
27.27Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
27.27Consensusrelaxin_onOrthosteric Ligandrxfp4_on
27.27Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
27.27Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
27.27Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
26.92Single3QAKUK-4320973QAK-A2A-UK-432097
26.92Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
26.92Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
26.92Single6HLOAprepitant6HLO-NK1-Aprepitant
26.92Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
26.92Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
26.92Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
26.92Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
26.92Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
26.92Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
26.92Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
26.92Single9E82SDF-1-beta9E82-ACKR3-SDF-1-β-Arrestin2
26.92Single9IQVMuscarinic toxin 39IQV-Alpha1A-Muscarinic toxin 3
26.92Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
26.92Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
26.92Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
26.92Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
26.92Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
26.67Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
26.67Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
26.67Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
26.67Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
26.67Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
26.47Consensusglucagon_onOrthosteric Ligandglp_on gluc_on secretin_on gip_on
26.32Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
26.32Single3ODUIT1t3ODU-CXCR4-IT1t
26.32Single3PWHZM-2413853PWH-A2A-ZM-241385
26.32Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
26.32Single4S0VSuvorexant4S0V-OX2-Suvorexant
26.32Single5ZKQABT-4915ZKQ-PAF-ABT-491
26.32Single6DS0Ly2660976DS0-5-HT2B-Ly266097
26.32Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
26.32Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
26.32Single6TPJSuvorexant6TPJ-OX2-Suvorexant
26.32Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
26.32Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
26.32Single7F8YDevazepide7F8Y-CCKA-Devazepide
26.32Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
26.32Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
26.32Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
26.32Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
26.32Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
26.32Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
26.32Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
26.32Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
26.32Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
26.32Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
26.32Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
26.32Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
26.32Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.32Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
26.32Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
26.32Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
26.32Single8GNGIstradefylline8GNG-A2A-Istradefylline
26.32Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
26.32Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
26.32Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
26.32Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
26.32Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.32Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.32Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.32Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
26.32Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
26.32Single8Y0HVUF114188Y0H-CXCR3-VUF11418
26.32Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go/β1/γ2
26.32Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
26.32Single9EBHAdenosine9EBH-A3A-Adenosine-Gi1/β1/γ2
26.32Single9EEAAdenosine9EEA-A2A-Adenosine-Gs/β1/γ2
26.32Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
26.32Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
26.32Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
26.32Consensusalpha2_offOrthosteric Ligandalpha2c_off
26.32Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
26.32Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
26.09Single4AMIBucindolol4AMI-β1-Bucindolol
26.09Single4PY02MeSATP4PY0-P2Y12-2MeSATP
26.09Single6A93Risperidone6A93-5-HT2A-Risperidone
26.09Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
26.09Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
26.09Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
26.09Single6IIURamatroban6IIU-TXA2-Ramatroban
26.09Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
26.09Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
26.09Single6ZG4HTL00099366ZG4-M1-HTL0009936
26.09Single7DFPSpiperone7DFP-D2-Spiperone
26.09Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
26.09Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
26.09Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
26.09Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
26.09Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
26.09Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
26.09Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
26.09Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
26.09Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
26.09Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
26.09Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
26.09Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
26.09Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
26.09Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
26.09Single8JWY2-1188JWY-A2A-2-118
26.09Single8JWZAB9288JWZ-A2A-AB928-Na
26.09Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
26.09Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
26.09Single9AU0BW245C9AU0-DP1-BW245C-Gs/β1/γ2
26.09Single9EBIPiclidenoson9EBI-A3A-Piclidenoson-chim(NtGi1L-Gs-CtGi1)/β1/γ2
26.09Single9GL2Befiradol9GL2-5-HT1A-Befiradol-Gs/β1/γ2
26.09Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
26.09Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
26.09Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
26.09Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
26.09Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
26.09Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
26.09Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
26.09Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
26.09Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
26.09Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
25.93Single5WF5UK-4320975WF5-A2A-UK-432097
25.93Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
25.93Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
25.93Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
25.93Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
25.93Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
25.93Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
25.93Single9M1OMorphine-Modulating Neuropeptide B9M1O-NPFF2-Morphine-Modulating Neuropeptide B-Gi1/β1/γ2
25.93Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
25.93Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
25.93Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
25.81Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
25.81Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
25.81Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
25.81Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
25.81Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
25.81Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
25.81Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
25.81Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
25.81Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
25.81Single9BYOExendin-39BYO-GLP-1-Exendin-3-Gs/β1/γ2
25.81Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
25.81Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
25.81Consensusbradykinin_onOrthosteric Ligandbk2_on
25.81Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
25.81Consensusendothelin_onOrthosteric Ligandetb_on eta_on
25.81Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
25.00Single2YDOAdenosine2YDO-A2A-Adenosine
25.00Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
25.00Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
25.00Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
25.00Single6H7LDobutamine6H7L-β1-Dobutamine
25.00Single6IBLArformoterol6IBL-β1-Arformoterol
25.00Single6IQLL7458706IQL-D4-L745870
25.00Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
25.00Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
25.00Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
25.00Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
25.00Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
25.00Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
25.00Single6TP3Nemorexant6TP3-OX1-Nemorexant
25.00Single6V9SGTPL114036V9S-OX1-GTPL11403
25.00Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
25.00Single6ZG9GSK10347026ZG9-M1-GSK1034702
25.00Single7AROLUF58337ARO-A2A-LUF5833-Na
25.00Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
25.00Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
25.00Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
25.00Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
25.00Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
25.00Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
25.00Single7EZCUKA7EZC-A2A-UKA
25.00Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
25.00Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
25.00Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
25.00Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
25.00Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
25.00Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
25.00Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
25.00Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
25.00Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
25.00Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
25.00Single7UL3Famotidine7UL3-H2-Famotidine
25.00Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
25.00Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
25.00Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
25.00Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
25.00Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
25.00Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
25.00Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
25.00Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
25.00Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
25.00Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
25.00Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
25.00Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
25.00Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
25.00Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
25.00Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
25.00Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
25.00Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
25.00Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
25.00Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
25.00Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
25.00Single8RLNLUF58348RLN-A2A-LUF5834
25.00Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
25.00Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
25.00Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
25.00Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
25.00Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
25.00Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
25.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
25.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
25.00Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
25.00Single8Y6YGLPG09748Y6Y-FFA2-GLPG0974
25.00Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
25.00Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ2
25.00Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
25.00Single9ARXSerotonin9ARX-5-HT2A-Serotonin
25.00Single9AS5Mescaline9AS5-5-HT2A-Mescaline
25.00Single9AS6Mescaline9AS6-5-HT2A-Mescaline-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
25.00Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
25.00Single9CGJC6-Quino9CGJ-δ-C6-Quino-Gi1/β1/γ2
25.00Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
25.00Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
25.00Single9GG5U466199GG5-TXA2-U46619-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Single9JFUNE52-QQ579JFU-GPR4-NE52-QQ57
25.00Single9JH3CMF-0199JH3-Apelin-CMF-019-Gi1/β1/γ2
25.00Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
25.00Single9M1HProstaglandin E29M1H-EP1-Prostaglandin E2-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
25.00Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
25.00Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
25.00Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
25.00Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
25.00Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
25.00Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
25.00Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
25.00Consensusfp-alpha_onOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
25.00Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
25.00Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
25.00Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
25.00Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
25.00Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Consensusprostanoid_offOrthosteric Ligandep_off dp_off
25.00Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
25.00Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
25.00Consensusvasop-oxy_onOrthosteric Ligandv2_on
25.00Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
24.32Consensusclass-b1_onOrthosteric Ligandglucagon_on vip-pacap_on pth_on crf_on calcitonin_on
24.32Consensuspth2_on_gpOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
24.24Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
24.24Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
24.24Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
24.24Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
24.14Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
24.14Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
24.14Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
24.14Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
24.14Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
24.14Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
24.14Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
24.14Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
24.00Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
24.00Single5WF6UK-4320975WF6-A2A-UK-432097
24.00Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
24.00Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
24.00Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
24.00Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
24.00Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
24.00Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
24.00Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
24.00Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
24.00Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
24.00Single9JF4PD1683689JF4-BB1-PD168368
24.00Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
24.00Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
24.00Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
23.81Single2Y02Carmoterol2Y02-β1-Carmoterol
23.81Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
23.81Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
23.81Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
23.81Single4QKX35V4QKX-β2-35V
23.81Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
23.81Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
23.81Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
23.81Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
23.81Single5TGZAM65385TGZ-CB1-AM6538
23.81Single5UENDU1725UEN-A1-DU172
23.81Single5UIGCmpd-15UIG-A2A-Cmpd-1
23.81Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
23.81Single6GPSMK08126GPS-CCR2-MK0812
23.81Single6H7MSalbutamol6H7M-β1-Salbutamol
23.81Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
23.81Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
23.81Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
23.81Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
23.81Single7BU7BI1671077BU7-β1-BI167107
23.81Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
23.81Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
23.81Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
23.81Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
23.81Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
23.81Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
23.81Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
23.81Single7WC7Lisuride7WC7-5-HT2A-Lisuride
23.81Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
23.81Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
23.81Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
23.81Single8CU6LJ-45178CU6-A2A-LJ-4517
23.81Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
23.81Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
23.81Single8JJOAlprenolol8JJO-β2-Alprenolol
23.81Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
23.81Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
23.81Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
23.81Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
23.81Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
23.81Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
23.81Single8X63Mepyramine8X63-H1-Mepyramine
23.81Single8X64Desloratadine8X64-H1-Desloratadine
23.81Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
23.81Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
23.81Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
23.81Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
23.81Single9H37A1IR09H37-A2A-A1IR0-Na
23.81Single9IYAONO-97105319IYA-GPR55-ONO-9710531
23.81Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
23.81Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
23.81Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
23.81Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
23.81Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
23.81Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
23.81Consensusalpha2_onOrthosteric Ligandalpha2b_on
23.81Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
23.81Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
23.81Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
23.81Consensuscck_offOrthosteric Ligandccka_off
23.81Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
23.81Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
23.81Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
23.81Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
23.81Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
23.81Consensushistamine_offOrthosteric Ligandh1_off
23.81Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
23.81Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
23.81Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
23.53Single3OE8IT1t3OE8-CXCR4-IT1t
23.53Single6TQ9SB-4081246TQ9-OX1-SB-408124
23.53Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
23.53Single8A2OTheophylline8A2O-A2A-Theophylline-Na
23.53Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.53Single8IWM2-Phenylethylamine8IWM-TA9-2-Phenylethylamine
23.53Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
23.53Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
23.53Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
23.53Single9CHUNoradrenaline9CHU-β2-Noradrenaline
23.53Consensusgs_histamineOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
23.53Consensush2_onOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
23.33Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
23.33Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
23.33Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
23.33Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
23.33Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
23.33Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
23.33Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
23.33Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
23.33Consensuspac_on_gpOrthosteric Ligandpac1_on_gp
23.08Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
23.08Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
23.08Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
23.08Single7F8XNN90567F8X-CCKA-NN9056
23.08Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
23.08Single8IEBA1LYA8IEB-GPR156-A1LYA
23.08Single8IEIA1LYA8IEI-GPR156-A1LYA
23.08Single8IEIA1LYA8IEI-GPR156-A1LYA
23.08Single8IEPA1LYA8IEP-GPR156-A1LYA
23.08Single8IEPA1LYA8IEP-GPR156-A1LYA
23.08Single8U4OCXCL128U4O-CXCR4-CXCL12-Gi1/β1/γ2
23.08Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
23.08Single8YWFRetatrutide8YWF-GLP-1-Retatrutide-chim(NtGi1-Gs)/β1/γ2
23.08Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
22.86Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
22.86Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
22.73Single4NTJAZD12834NTJ-P2Y12-AZD1283
22.73Single5N2RPSB-365N2R-A2A-PSB-36-Na
22.73Single5N2SPSB365N2S-A1-PSB36
22.73Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
22.73Single5WIUNemonapride5WIU-D4-Nemonapride
22.73Single5WIVNemonapride5WIV-D4-Nemonapride-Na
22.73Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
22.73Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
22.73Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
22.73Single6D26Fevipiprant6D26-DP2-Fevipiprant
22.73Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
22.73Single6GPXMK08126GPX-CCR2-MK0812
22.73Single6HLPNetupitant6HLP-NK1-Netupitant
22.73Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
22.73Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
22.73Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.73Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
22.73Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
22.73Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
22.73Single8QOTNanobody-E8QOT-μ-Nanobody-E
22.73Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
22.73Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
22.73Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
22.73Single9ARYSerotonin9ARY-5-HT2A-Serotonin-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73Single9ARZ2-bromo-LSD9ARZ-5-HT2A-2-bromo-LSD
22.73Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
22.73Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
22.73Single9F34FOB02-04A9F34-D3-FOB02-04A-Go/β1/γ2
22.73Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
22.73Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
22.73Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
22.73Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
22.73Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
22.73Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
22.73Consensusadenosine_offOrthosteric Liganda1_off a2_off
22.73Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
22.73Consensusblt_offOrthosteric Ligandblt1_off
22.73Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
22.73Consensusdp_offOrthosteric Liganddp2_off
22.73Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
22.73Consensusep_offOrthosteric Ligandep4_off
22.58Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
22.58Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
22.58Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
22.58Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
22.58Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
22.58Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
22.58Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
22.58Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
22.58Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
22.58Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
22.58Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
22.22Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
22.22Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
22.22Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
22.22Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
22.22Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
22.22Single7XNACYN1548067XNA-SST2-CYN154806
22.22Single8IEBA1LYA8IEB-GPR156-A1LYA
22.22Single8IW72-Phenylethylamine8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
22.22Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
22.22Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
22.22Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
22.22Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
22.22Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
22.22Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
22.22Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
22.22Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
22.22Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
22.22Single9JHJC18:0 Ceramide9JHJ-FPR2-ALX-C18:0 Ceramide-Gi1/β1/γ2
22.22Single9KFIRelaxin-39KFI-RXFP3-Relaxin-3-Gi2/β1/γ2
22.22Single9LRCHistamine9LRC-H4-Histamine
22.22Single9LREHistamine9LRE-H4-Histamine-Gi1/β1/γ2
22.22Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
22.22Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
22.22Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
22.22Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
22.22Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
22.22Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
21.95Consensusclass-b1_on_gpOrthosteric Ligandglucagon_on_gp vip-pacap_on_gp pth_on_gp crf_on_gp calcitonin_on_gp
21.88Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
21.88Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
21.88Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
21.88Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
21.88Single8IY6Endothelin-18IY6-ETB-Endothelin-1
21.88Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
21.88Consensusvip-pacap_onOrthosteric Ligandvpac_on pac_on
21.88Consensusvip-pacap_on_gpOrthosteric Ligandvpac_on_gp pac_on_gp
21.74Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
21.74Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
21.74Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
21.74Single4BV0Neurotensin4BV0-NTS1-Neurotensin
21.74Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
21.74Single4U15Tiotropium4U15-M3-Tiotropium
21.74Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
21.74Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
21.74Single6E59L-7607356E59-NK1-L-760735
21.74Single6J20Aprepitant6J20-NK1-Aprepitant
21.74Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
21.74Single6OL9Tiotropium6OL9-M5-Tiotropium
21.74Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
21.74Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
21.74Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
21.74Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
21.74Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
21.74Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.74Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
21.74Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
21.74Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.74Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
21.74Single8GDBPGE28GDB-EP4-PGE2-Gs/β1/γ2
21.74Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
21.74Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
21.74Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
21.74Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
21.74Single8YNTSNAP-948478YNT-MCH1-SNAP-94847
21.74Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
21.74Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
21.74Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
21.74Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
21.74Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
21.74Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
21.74Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
21.74Consensusneurotensin_onOrthosteric Ligandnts1_on
21.74Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
21.74Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
21.74Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
21.43Single3OE0CVX153OE0-CXCR4-CVX15
21.43Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.43Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
21.43Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
21.43Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
21.43Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
21.43Single9B5YLong-Acting PTH9B5Y-PTH1-Long-Acting PTH-chim(NtGi1-Gq)/β1/γ2
21.43Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
21.43Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
21.43Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
21.43Consensusclass-b1_class-b2_cons_onOrthosteric Ligandclass-b1_on class-b2_on
21.43Consensusclass-b1_class-b2_cons_on_gpOrthosteric Ligandclass-b1_on_gp class-b2_on_gp
21.43Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
21.43Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
21.43Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
21.43Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
21.21Single7RBTTirzepatide7RBT-GIP-Tirzepatide-LSN3556672-chim(NtGi1-Gs)/β1/γ2
21.05Single3PBLEticlopride3PBL-D3-Eticlopride
21.05Single6HLLCP999946HLL-NK1-CP99994
21.05Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
21.05Single6TP4ACT-4622066TP4-OX1-ACT-462206
21.05Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
21.05Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
21.05Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
21.05Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
21.05Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
21.05Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
21.05Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
21.05Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.05Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
21.05Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
21.05Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
21.05Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
21.05Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
21.05Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.05Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
21.05Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
21.05Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
21.05Single8YN7Immethridine8YN7-H3-Immethridine-Go/β1/γ2
21.05Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
21.05Single9AS7Psilocin9AS7-5-HT2A-Psilocin
21.05Single9B9Y7DY9B9Y-CB1-7DY
21.05Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
21.05Single9LMPNE52-QQ579LMP-GPR4-NE52-QQ57
21.05Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
21.05Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
20.83Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
20.83Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
20.83Single4N4WSANT-14N4W-SMO-SANT-1
20.83Single4XEENeurotensin4XEE-NTS1-Neurotensin
20.83Single4XESNeurotensin4XES-NTS1-Neurotensin
20.83Single5CXVTiotropium5CXV-M1-Tiotropium
20.83Single5TZYMK8666; AP85TZY-FFA1-MK8666; AP8
20.83Single5X33BIIL2605X33-BLT1-BIIL260
20.83Single6CM4Risperidone6CM4-D2-Risperidone
20.83Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
20.83Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
20.83Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
20.83Single7K15MKD0467K15-BLT1-MKD046-Na
20.83Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
20.83Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
20.83Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.83Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
20.83Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.83Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
20.83Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
20.83Single8JD3JNJ-404118138JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
20.83Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
20.83Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.83Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
20.83Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
20.83Single8Y6WTUG-13758Y6W-FFA2-TUG-1375-4-CMTB-Gi1/β1/γ2
20.83Single9BJKNAM9BJK-μ-Naloxone-NAM
20.83Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
20.83Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
20.83Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
20.83Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
20.83Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
20.83Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
20.83Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
20.83Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
20.83Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
20.83Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
20.83Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
20.83Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
20.83Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
20.83Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
20.69Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
20.69Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
20.69Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
20.69Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
20.69Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
20.69Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
20.69Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
20.00Single4BUONeurotensin4BUO-NTS1-Neurotensin
20.00Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
20.00Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
20.00Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
20.00Single5U09Taranabant5U09-CB1-Taranabant
20.00Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
20.00Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
20.00Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
20.00Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
20.00Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
20.00Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
20.00Single6ME2Ramelteon6ME2-MT1-Ramelteon
20.00Single6ME9Ramelteon6ME9-MT2-Ramelteon
20.00Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
20.00Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
20.00Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
20.00Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
20.00Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
20.00Single7BR3Elagolix7BR3-GnRH1-Elagolix
20.00Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
20.00Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
20.00Single7F8ULintitript7F8U-CCKA-Lintitript
20.00Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
20.00Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
20.00Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
20.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
20.00Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
20.00Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
20.00Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
20.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
20.00Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
20.00Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
20.00Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
20.00Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
20.00Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
20.00Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
20.00Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
20.00Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
20.00Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
20.00Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
20.00Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
20.00Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
20.00Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
20.00Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
20.00Single8IWESpermidine8IWE-TA9-Spermidine
20.00Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
20.00Single8JPFNeurotensin8JPF-NTS1-Neurotensin-SBI-553
20.00Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
20.00Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
20.00Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
20.00Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
20.00Single8T3OTUG-8918T3O-FFA4-TUG-891-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Single8U4PAMD31008U4P-CXCR4-AMD3100-Gi1/β1/γ2
20.00Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
20.00Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ2
20.00Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
20.00Single8ZPLHF511168ZPL-CXCR4-HF51116
20.00Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
20.00Single9AS02-bromo-LSD9AS0-5-HT2A-2-bromo-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
20.00Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
20.00Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
20.00Single9DYEBuspirone9DYE-5-HT1A-Buspirone-Go/β1/γ2
20.00Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
20.00Single9LRBHistamine9LRB-H1-Histamine-Gs/β1/γ2
20.00Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
20.00Consensusangiotensin_offOrthosteric Ligandat1_off
20.00Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
20.00Consensuschemerin_onOrthosteric Ligandcml1_on
20.00Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
20.00Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
20.00Consensuscrf1_on_gpOrthosteric Ligand6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF1-Corticoliberin-Gs/β1/γ2
20.00Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
20.00Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
20.00Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
20.00Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
20.00Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
20.00Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
20.00Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
20.00Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
20.00Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
20.00Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
20.00Consensuspac_onOrthosteric Ligandpac1_on
20.00Consensusvpac_onOrthosteric Ligandvpac1_on vpac2_on
19.44Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
19.35Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
19.35Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
19.35Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
19.35Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
19.35Single7SK3CXCL127SK3-ACKR3-CXCL12
19.35Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
19.35Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
19.35Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
19.35Consensussecretin_onOrthosteric Ligand7D3S-Secretin-Secretin-Gs/β1/γ2
19.35Consensusvpac_on_gpOrthosteric Ligandvpac1_on_gp vpac2_on_gp
19.23Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
19.23Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
19.23Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
19.23Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
19.23Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
19.23Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
19.23Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
19.23Single9MD1Buspirone9MD1-5-HT1A-Buspirone-Gz/β1/γ2
19.23Single9NS9TUG-13759NS9-FFA2-TUG-1375-Compound 187-Gi1/β1/γ2
19.23Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
19.23Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
19.05Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
19.05Single3REYXAC3REY-A2A-XAC
19.05Single3RZECidoxepin3RZE-H1-Cidoxepin
19.05Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
19.05Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
19.05Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
19.05Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
19.05Single5IU7Q274563465IU7-A2A-Q27456346-Na
19.05Single5IUBQ274563445IUB-A2A-Q27456344-Na
19.05Single5JTBZM-2413855JTB-A2A-ZM-241385
19.05Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
19.05Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
19.05Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
19.05Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
19.05Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
19.05Single6A94Zotepine6A94-5-HT2A-Zotepine
19.05Single6AQFZM-2413856AQF-A2A-ZM-241385
19.05Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
19.05Single6KUXRS-799486KUX-α2a-RS-79948
19.05Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
19.05Single6MH8ZM-2413856MH8-A2A-ZM-241385
19.05Single6TPKRetosiban6TPK-OT-Retosiban
19.05Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
19.05Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
19.05Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
19.05Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
19.05Single7T32ZM-2413857T32-A2A-ZM-241385
19.05Single7T94Acetylcholine7T94-M2-Acetylcholine-LY2119620-chim(NtGi1-Go)/β1/γ2
19.05Single7T94LY21196207T94-M2-Acetylcholine-LY2119620-chim(NtGi1-Go)/β1/γ2
19.05Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
19.05Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
19.05Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
19.05Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
19.05Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
19.05Single8K2WAMG4878K2W-CXCR3-AMG487
19.05Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
19.05Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
19.05Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
19.05Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
19.05Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
19.05Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
19.05Single8YRGFospropofol8YRG-MRGPRX4-Fospropofol-chim(NtGi1-Gs-CtGq)/β1/γ2
19.05Single8ZPMAMD0708ZPM-CXCR4-AMD070
19.05Single8ZPNAMD31008ZPN-CXCR4-AMD3100
19.05Single9AS3LSD9AS3-5-HT2A-LSD
19.05Single9AS4LSD9AS4-5-HT2A-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
19.05Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
19.05Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
19.05Single9BA0A1AKN9BA0-CB1-A1AKN
19.05Single9IXXLTD49IXX-CysLT2-LTD4-chim(NtGi1-Gs-CtGq)/β1/γ2
19.05Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Gi1/β1/γ2
19.05Single9LRDHistamine9LRD-H1-Histamine-Gi1/β1/γ2
19.05Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
19.05Consensusa2_offOrthosteric Liganda2a_off
19.05Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
19.05Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
19.05Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
19.05Consensusgrh_offOrthosteric Ligandgnrh1_off
19.05Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
19.05Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
19.05Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
19.05Consensusvasop-oxy_offOrthosteric Ligandot_off
18.75Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
18.75Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
18.75Single8GEJConstrained Epinephrine8GEJ-β2-Constrained Epinephrine-Gs/β1/γ2
18.75Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
18.75Single9BUCCagrilintide9BUC-CT-Cagrilintide-Gs/β1/γ2
18.75Consensussecretin_on_gpOrthosteric Ligand7D3S-Secretin-Secretin-Gs/β1/γ2
18.52Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
18.52Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
18.52Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
18.52Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
18.52Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
18.52Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
18.52Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
18.52Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
18.52Consensussomatostatin_offOrthosteric Ligandsst2_off
18.18Single2Y01Dobutamine2Y01-β1-Dobutamine
18.18Single3EMLZM-2413853EML-A2A-ZM-241385
18.18Single4DAJTiotropium4DAJ-M3-Tiotropium
18.18Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
18.18Single4MQSIperoxo4MQS-M2-Iperoxo
18.18Single4QIMANTA XV4QIM-SMO-ANTA XV
18.18Single4U14Tiotropium4U14-M3-Tiotropium
18.18Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
18.18Single5IU8Q274563475IU8-A2A-Q27456347-Na
18.18Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
18.18Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
18.18Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
18.18Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
18.18Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
18.18Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
18.18Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
18.18Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
18.18Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
18.18Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
18.18Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
18.18Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/β1/γ2
18.18Single6S0LZM-2413856S0L-A2A-ZM-241385
18.18Single6XBM5LWE6XBM-SMO-5LWE-Gi1/β1/γ2
18.18Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
18.18Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
18.18Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
18.18Single7PYRPSB-21157PYR-A2A-PSB-2115
18.18Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
18.18Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
18.18Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
18.18Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
18.18Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
18.18Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
18.18Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
18.18Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
18.18Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
18.18Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
18.18Single8YN8Proxyfan8YN8-H3-Proxyfan-Go/β1/γ2
18.18Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
18.18Single8ZYYNeurotensin peptide 8-138ZYY-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
18.18Single9AS1DMT9AS1-5-HT2A-DMT
18.18Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
18.18Single9IVGGLP-1 (Truncated)9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
18.18Single9JEAAtropine9JEA-M1-Atropine
18.18Single9JGKBalovaptan9JGK-5-HT2B-Balovaptan
18.18Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
18.18Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
18.18Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
18.18Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
18.18Consensuspth1_onOrthosteric Ligand6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
17.86Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
17.86Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
17.86Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
17.86Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
17.86Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
17.86Single9IQRMuscarinic toxin 39IQR-α2a-Muscarinic toxin 3
17.86Single9IQSMuscarinic toxin 39IQS-M4-Muscarinic toxin 3
17.65Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
17.65Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
17.65Single8PWNTheophylline8PWN-A2A-Theophylline
17.65Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
17.65Consensuscrf1_onOrthosteric Ligand6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF1-Corticoliberin-Gs/β1/γ2
17.39Single2Y00Dobutamine2Y00-β1-Dobutamine
17.39Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
17.39Single5IUAQ274563485IUA-A2A-Q27456348-Na
17.39Single5T1ABMS-6815T1A-CCR2-BMS-681-PubChem 12093170
17.39Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
17.39Single6S0QZM-2413856S0Q-A2A-ZM-241385
17.39Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
17.39Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
17.39Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
17.39Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
17.39Single7SINNPS-21437SIN-CaS-NPS-2143
17.39Single7SINNPS-21437SIN-CaS-NPS-2143
17.39Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
17.39Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
17.39Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
17.39Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.39Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
17.39Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
17.39Single8GNEKW-63568GNE-A2A-KW-6356-Na
17.39Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
17.39Single8ZMFA1L108ZMF-5-HT2C-A1L10
17.39Single9B9ZA1AKO9B9Z-CB1-A1AKO
17.39Single9DYDAsenapine9DYD-5-HT1A-Asenapine-Go/β1/γ2
17.39Single9DYFAsenapine9DYF-5-HT1A-Asenapine-Gi1/β1/γ2
17.39Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
17.39Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
17.39Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
17.39Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.39Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.14Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
17.14Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
17.14Single9AUCCalcitonin gene-related peptide-19AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
16.67Single3RFMCaffeine3RFM-A2A-Caffeine
16.67Single5TZRMK86665TZR-FFA1-MK8666
16.67Single5V54Methiothepin5V54-5-HT1B-Methiothepin
16.67Single5V56TC1145V56-SMO-TC114
16.67Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
16.67Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
16.67Single6OS1TRV0266OS1-AT1-TRV026
16.67Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
16.67Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
16.67Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
16.67Single7PX4PSB-21137PX4-A2A-PSB-2113
16.67Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
16.67Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
16.67Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
16.67Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single8EA0Iperoxo8EA0-M3-Iperoxo
16.67Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
16.67Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single8WC5Tetramethylammonium Ion8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
16.67Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
16.67Single9EBOGLP-1 (ACPC18)9EBO-GLP-1-GLP-1 (ACPC18)-Gs/β1/γ2
16.67Single9EE9Adenosine9EE9-A2A-Adenosine-Gs/β1/γ2
16.67Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
16.67Consensus5ht1_offOrthosteric Ligand5ht1b_off
16.67Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
16.67Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
16.67Consensusglp1_on_gpOrthosteric Ligand7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
16.67Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
16.67Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
16.67Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
16.67Consensuspth1_on_gpOrthosteric Ligand6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
16.67Consensustachykinin_offOrthosteric Ligandnk1_off
16.22Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
16.22Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
16.13Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
16.13Consensuscalcitonin_onOrthosteric Ligandctlike_on
16.13Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
16.13Consensusvpac1_onOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
16.00Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
16.00Single6OS2TRV0266OS2-AT1-TRV026
16.00Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
16.00Single6YVRNTS8-136YVR-NTS1-NTS8-13
16.00Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
16.00Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
16.00Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
16.00Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
16.00Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
16.00Single9CM3TUG-13759CM3-FFA2-TUG-1375-Compound 187-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.79Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
15.79Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
15.79Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
15.79Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
15.79Single6ME5Agomelatine6ME5-MT1-Agomelatine
15.79Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
15.79Single7WC5Psilocin7WC5-5-HT2A-Psilocin
15.79Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.79Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.79Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
15.79Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
15.79Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
15.79Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
15.79Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
15.79Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
15.79Consensusgluc_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
15.62Single9BLWCagrilintide backbone (non-acylated)9BLW-CT (AMY1)-Cagrilintide backbone (non-acylated)-Gs/β1/γ2; RAMP1
15.62Consensuscalcitonin_on_gpOrthosteric Ligandctlike_on_gp
15.62Consensuscrf2_on_gpOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
15.62Consensuspac1_onOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
15.62Consensuspac1_on_gpOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
15.62Consensusvpac1_on_gpOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
15.38Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
15.38Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
15.38Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
15.38Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-SBI-553-chim(NtGi1-Go)/β1/γ2
15.38Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
15.38Single9C0KExendin-49C0K-GLP-1-Exendin-4-Gs/β1/γ2
15.38Consensusgluc_on_gpOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
15.15Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
15.00Single5L7IVismodegib5L7I-SMO-Vismodegib
15.00Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
15.00Single6LI0C176LI0-GPR52-C17
15.00Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
15.00Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
15.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
15.00Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
15.00Single7V68Iperoxo7V68-M4-Iperoxo-LY2119620-Gi1/β1/γ2
15.00Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
15.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
15.00Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
15.00Single8YN2Histamine8YN2-H1-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.00Single9AS2DMT9AS2-5-HT2A-DMT-chim(NtGi1-Gs-CtGq)/β1/γ2
15.00Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg4_on
15.00Consensusadgrg_on_gpOrthosteric Ligandadgrg2_on_gp adgrg4_on_gp
15.00Consensusgq_nucleotideOrthosteric Ligandgq_p2y
15.00Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
15.00Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
14.81Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
14.81Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
14.81Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
14.81Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
14.81Single9CM7TUG-13759CM7-FFA2-TUG-1375-AZ-1729-Gi1/β1/γ2
14.71Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
14.71Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
14.71Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
14.71Consensusvpac2_on_gpOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
14.63Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
14.29Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
14.29Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
14.29Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
14.29Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
14.29Single4BWBNeurotensin4BWB-NTS1-Neurotensin
14.29Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
14.29Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
14.29Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
14.29Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
14.29Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
14.29Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
14.29Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
14.29Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
14.29Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
14.29Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
14.29Single8T3VDocosa-4,7,10,13,16,19-Hexaenoic acid8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29Single8XWNCXCL88XWN-CXCR2-CXCL8
14.29Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
14.29Single9BUECagrilintide9BUE-CT-Cagrilintide-Gs/β1/γ2
14.29Single9H2XA1IR19H2X-A2A-A1IR1-Na
14.29Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
14.29Consensusgip_onOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
14.29Consensusgip_on_gpOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
14.29Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
14.29Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
14.29Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
14.29Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
13.89Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
13.89Consensusglp1_onOrthosteric Ligand7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
13.79Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
13.79Single7SK5CXCL127SK5-ACKR3-CXCL12
13.64Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
13.64Single5UVIZM-2413855UVI-A2A-ZM-241385
13.64Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
13.64Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
13.64Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
13.64Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
13.64Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
13.64Single6ZINSR486926ZIN-NTS1-SR48692
13.64Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
13.64Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
13.64Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
13.64Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
13.64Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
13.64Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
13.64Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
13.64Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
13.64Single9K0KUTP9K0K-P2Y4-UTP-chim(NtGi1-Gs-CtGq)/β1/γ2
13.64Single9K0XATP9K0X-P2Y2-ATP-chim(NtGi1-Gs-CtGq)/β1/γ2
13.64Single9K20ATP9K20-P2Y2-ATP-chim(NtGi1-Go)/β1/γ2
13.64Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
13.64Consensusopsins_offOrthosteric Ligandrhodopsin_off
13.64Consensussensory_offOrthosteric Ligandopsins_off
13.16Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
13.04Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
13.04Single5DSGTiotropium5DSG-M4-Tiotropium
13.04Single5T04Neurotensin5T04-NTS1-Neurotensin
13.04Single6D27CAY104716D27-DP2-CAY10471
13.04Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.04Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
13.04Single7F83PF-051904577F83-Ghrelin-PF-05190457
13.04Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
13.04Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
13.04Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
13.04Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
13.04Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
12.90Single9BLCCagrilintide backbone (non-acylated)9BLC-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
12.50Single4JKVTaladegib4JKV-SMO-Taladegib
12.50Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
12.50Single5CGCHTL142425CGC-mGlu5-HTL14242
12.50Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
12.50Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
12.50Single6LUQHaloperidol6LUQ-D2-Haloperidol
12.50Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
12.50Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
12.50Single6Z4SSR486926Z4S-NTS1-SR48692
12.50Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
12.50Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
12.50Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
12.50Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
12.50Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
12.50Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
12.50Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
12.50Single8ZYTNeurotensin peptide 8-138ZYT-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
12.50Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single9HC04YI9HC0-mGlu5-4YI
12.50Consensusadgrg2_onOrthosteric Ligand7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
12.50Consensusadgrg2_on_gpOrthosteric Ligand7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
12.50Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
12.12Single9BP3Cagrilintide9BP3-CT (AMY1)-Cagrilintide-Gs/β1/γ2; RAMP1
12.00Single5V57TC1145V57-SMO-TC114
12.00Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
12.00Single7F1TMIP-1a7F1T-CCR5-MIP-1a
12.00Single7P2L4YI7P2L-mGlu5-4YI
12.00Single7R0CAVP7R0C-V2-AVP-Arrestin2
12.00Single7T9NDPPC7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
12.00Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
12.00Single8JD5JNJ-40411813; ADX881788JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
12.00Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
12.00Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
12.00Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
12.00Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
12.00Single9AS9RS130-1809AS9-5-HT2A-RS130-180
12.00Single9ASARS130-1809ASA-5-HT2A-RS130-180-chim(NtGi1-Gs-CtGq)/β1/γ2
12.00Single9CLWTUG-13759CLW-FFA2-TUG-1375-4-CMTB-chim(NtGi1L-Gs-CtGq)/β1/γ2
11.76Single5MZPCaffeine5MZP-A2A-Caffeine-Na
11.76Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
11.76Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
11.76Consensusglp2_on_gpOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
11.63Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
11.54Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
11.54Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
11.54Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.54Single8XQJJN2418XQJ-Apelin-JN241
11.43Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
11.11Single3PXOAll-trans-Retinal3PXO-Rhodopsin-All-trans-Retinal
11.11Single5CGDHTL142425CGD-mGlu5-HTL14242
11.11Single5DYSAll-trans-Retinal5DYS-Rhodopsin-All-trans-Retinal
11.11Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
11.11Single7V68LY21196207V68-M4-Iperoxo-LY2119620-Gi1/β1/γ2
11.11Single7WC4Serotonin7WC4-5-HT2A-Serotonin
11.11Single7XKDBeta-Hydroxyandrosterone7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
11.11Single8XVUCXCL28XVU-CXCR2-CXCL2
11.11Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
10.71Single8XQJJN2418XQJ-Apelin-JN241
10.53Single2HPYAll-trans-Retinal2HPY-Rhodopsin-All-trans-Retinal
10.53Single6OY9All-trans-Retinal6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
10.53Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
10.53Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
10.53Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
10.53Single9IVMLSN33188399IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
10.53Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
10.53Consensusp2y_offOrthosteric Ligandp2y1_off
10.53Consensussensory_onOrthosteric Ligandopsins_on
10.34Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
10.34Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
10.34Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
10.00Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
10.00Single3PQRAll-trans-Retinal3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
10.00Single3UZAGTPL92363UZA-A2A-GTPL9236
10.00Single4XNWMRS25004XNW-P2Y1-MRS2500
10.00Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
10.00Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
10.00Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
10.00Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
10.00Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/β1/γ2
10.00Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
10.00Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
10.00Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
10.00Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
10.00Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
10.00Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
9.52Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
9.52Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
9.52Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
9.52Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
9.52Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
9.52Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
9.52Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
9.52Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.52Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
9.52Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
9.52Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
9.52Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
9.52Single8HSCFab0468HSC-GPR20-Fab046-Gi1/β1/γ2
9.52Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab
9.52Single8ZYUNeurotensin peptide 8-138ZYU-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
9.52Single9EPRRetinal9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
9.38Single9BUDCagrilintide9BUD-CT-Cagrilintide-Gs/β1/γ2
9.38Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
9.09Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
9.09Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
9.09Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
9.09Single7VVOPTH7VVO-PTH1-PTH-Gs/β1/γ2
9.09Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
9.09Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
9.09Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
9.09Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
9.09Single8YYWAlpha-ketoglutarate8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
9.09Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
9.09Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
9.09Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
8.82Single9BLBCagrilintide backbone (non-acylated)9BLB-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
8.70Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
8.70Single7UTZDPPC7UTZ-TSH-TR1402-DPPC-Gs/β1/γ2
8.70Single7VODCariprazine7VOD-5-HT2A-Cariprazine
8.70Single7VV6C48/807VV6-MRGPRX2-C48/80
8.70Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ2
8.57Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
8.33Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
8.33Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
8.33Single8TH3AT118-H Nanobody8TH3-AT1-AT118-H Nanobody
8.33Single9BQ3Cagrilintide9BQ3-CT (AMY2)-Cagrilintide-Gs/β1/γ2; RAMP2
8.33Single9BTWCagrilintide9BTW-CT (AMY3)-Cagrilintide-Gs/β1/γ2; RAMP3
8.33Single9IMATalquetamab9IMA-GPRC5D-Talquetamab
8.00Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
8.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
8.00Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
8.00Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
8.00Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
7.69Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
7.69Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
7.69Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Gi1/β1/γ1
7.69Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
7.41Single8XWACXCL18XWA-CXCR2-CXCL1
7.41Single8XWMCXCL68XWM-CXCR2-CXCL6
7.41Single8XWSCXCL58XWS-CXCR2-CXCL5
7.41Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
7.14Single8XWFCXCL38XWF-CXCR2-CXCL3
7.14Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
7.14Single9JH5C16:0 Ceramide9JH5-CysLT2-C16:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
6.90Single6KNMJN241-96KNM-Apelin-JN241-9
6.25Consensusclass-b2_onOrthosteric Ligandadgrg_on adgrf_on adgrl_on adgre_on adgrd_on
6.25Consensusclass-b2_on_gpOrthosteric Ligandadgrg_on_gp adgrf_on_gp adgrl_on_gp adgre_on_gp adgrd_on_gp
5.88Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
5.71Single9BUBCagrilintide9BUB-CT-Cagrilintide-Gs/β1/γ2
5.71Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
5.56Single4A4MAll-trans-Retinal4A4M-Rhodopsin-All-trans-Retinal-Gt(CT)
5.56Single5EN0All-trans-Retinal5EN0-Rhodopsin-All-trans-Retinal-Gt(CT)
5.56Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/β1/γ2
5.41Consensusctlike_on_gpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
5.26Single6VCBLSN31604406VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
5.26Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
5.26Single8HS2Fab0468HS2-GPR20-Fab046
5.26Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
5.00Single6XBM5LWE6XBM-SMO-5LWE-Gi1/β1/γ2
5.00Single7Y14Beta-Alanine7Y14-MRGPRD-β-Alanine
5.00Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Gi1/β1/γ2
5.00Single8Y02Retinal8Y02-OPN1SW-Retinal-Gi1/β1/γ2
4.76Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
4.76Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
4.76Single7Y12Beta-Alanine7Y12-MRGPRD-β-Alanine-Gi1/β1/γ2
4.76Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
4.76Single8J6QCompound 9n8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
4.76Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
4.76Consensusgi_sensoryOrthosteric Ligandgi_opsins
4.76Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
4.76Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
4.55Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
4.55Single4O9RCyclopamine4O9R-SMO-Cyclopamine
4.55Single7UL2SR486927UL2-NTS1-SR48692-Na
4.55Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
4.55Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/β1/γ2
4.55Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
4.55Single8YKDDehydroepiandrosterone8YKD-ADGRG2-Dehydroepiandrosterone-chim(NtGi1-Gs)/β1/γ2
4.55Single9E7RGB889E7R-PAR2-GB88-chim(NtGi1L-Gs-CtGq)/β1/γ2
4.55Consensusneurotensin_offOrthosteric Ligandnts1_off
4.55Consensusnts1_offOrthosteric Ligand7UL2-NTS1-SR48692-Na
4.35Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
4.35Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
4.35Single4QINSAG1.54QIN-SMO-SAG1.5
4.35Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
4.35Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
4.35Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
4.35Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
4.17Single6FFIMMPEP6FFI-mGlu5-MMPEP
4.17Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
4.17Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
4.17Single8IYXYL-3658IYX-GPR34-YL-365
4.00Single6FFHFenobam6FFH-mGlu5-Fenobam
3.85Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
3.85Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
3.85Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
3.70Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB

Consensus Members
Id Members
6KPG 6KPG-CB1-AM841-Gi1/β1/γ2
8K8J 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
Net Summary
Imin 3.025
Number of Linked Nodes 915
Number of Links 1120
Number of Hubs 191
Number of Links mediated by Hubs 710
Number of Communities 19
Number of Nodes involved in Communities 245
Number of Links involved in Communities 374
Path Summary
Number Of Nodes in MetaPath 114
Number Of Links MetaPath 113
Number of Shortest Paths 4681335
Length Of Smallest Path 3
Average Path Length 41.3461
Length of Longest Path 77
Minimum Path Strength 0.7025
Average Path Strength 6.05756
Maximum Path Strength 21.48
Minimum Path Correlation 0.7
Average Path Correlation 0.991345
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.72414
Average % Of Corr. Nodes 31.1164
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 58.9543
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following differences:
Id1st Network2nd Network
cb1_off_on_gpcb1_on_gpcb1_off
This network is also present in following consensuses:
IdComponents
cannabinoid_on_gpcb2_on_gp
cb1_on_gp



You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download cb1_on_gp.zip



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