Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
1G.HN.11 2.40967502
2G.S1.02 5.17533525
3G.S1.05 6.50875419
4G.H1.01 5.40583429
5G.H1.08 5.85833428
6G.S2.06 7.75542429
7G.S2.08 7.21917425
8G.S3.01 6.11917424
9G.S3.03 8.081527
10G.S3.04 7.745416
11G.S3.05 4.20083427
12G.S3.06 8.181515
13G.H2.03 6.43125419
14G.H2.04 4.01875409
15G.H2.06 5.90024719
16G.H2.07 5.87738719
17G.h2s4.01 7.405519
18G.S4.02 4.502518
19G.S4.04 6.18292419
20G.s4h3.04 6.720335168
21G.s4h3.05 6.557924169
22G.H3.01 4.90125409
23G.H3.03 3.172675124
24G.H3.06 4.66042406
25G.H3.09 6.73714719
26G.H3.13 4.59875415
27G.H3.17 8.22305615
28G.H3.18 5.157519
29G.S5.03 3.62208428
30G.S5.04 4.48567519
31G.S5.07 4.48208429
32G.HG.04 6.568675169
33G.HG.15 4.08333507
34G.hgh4.02 7.108675127
35G.hgh4.05 6.19333407
36G.H4.03 5.28867504
37G.H4.05 2.691254194
38G.H4.10 8.652924126
39G.H4.15 6.375418
40G.h4s6.02 5.71042418
41G.S6.02 9.14708407
42G.s6h5.01 6.73667429
43G.s6h5.02 3.0025407
44G.s6h5.05 3.02333409
45G.H5.03 7.28917428
46G.H5.06 8.465423
47G.H5.08 6.53417428
48G.H5.13 8.8825408
49G.H5.25 5.50567507
50b.1x1 2.035404
51b.1x7 2.915408
52b.1x16 2.35125404
53b.1x19 4.94583406
54b.h2x1 4.68405
55b.lhb1x3 2.13542402
56b.b1x3 3.53875477
57b.b1x4 4.45375477
58b.l1x3 7.50333749
59b.b2x1 10.2287518
60b.b2x5 7.12067547
61b.b3x3 4.93917408
62b.l3x2 5.09933549
63b.b4x3 5.66208497
64b.b4x4 9.27625448
65b.b4x5 4.636674157
66b.b4x6 9.30786749
67b.b5x2 5.23958407
68b.b5x3 6.64405749
69b.b5x5 5.981674155
70b.b5x7 6.7125407
71b.l5x1 4.96667498
72b.l5x2 4.39125496
73b.l5x5 9.14806619
74b.b6x5 4.22317156
75b.b7x1 6.99167404
76b.l7x2 4.70583419
77b.b8x3 5.02833406
78b.b8x4 6.19167596
79b.l8x5 2.26033503
80b.b9x3 5.49417496
81b.l9x3 8.67533589
82b.l9x6 5.88071718
83b.b10x5 4.55389609
84b.b11x2 4.4875407
85b.l11x2 7.92875489
86b.b12x3 3.97667458
87b.b12x6 8.48214788
88b.b12x7 5.349584219
89b.b13x7 7.95167557
90b.l13x3 7.61333659
91b.l13x6 7.43792419
92b.b14x3 5.7455
93b.b15x1 6.52881759
94b.b15x2 7.28458416
95b.l15x1 4.72967517
96b.b16x4 10.735456
97b.b16x5 5.37583405
98b.b16x6 8.99833658
99b.b17x5 7.39875417
100b.b17x7 8.775418
101b.l17x3 8.04619719
102b.l17x6 6.59519
103b.b18x3 4.76875418
104b.l18x1 6.9256106
105b.l18x2 5.717084107
106b.b19x2 8.22433516
107b.b19x4 6.83583418
108b.l19x2 6.58633519
109b.b20x4 11.4253518
110b.b20x6 6.75452716
111b.b21x1 9.88708417
112b.b21x2 3.595406
113b.b21x5 5.78792404
114b.b21x7 7.51933505
115b.l21x2 4.90792404
116b.b22x5 5.679446107
117b.l22x5 6.818336179
118b.b23x1 4.00917405
119b.b23x6 7.041197147
120b.b24x6 6.84254148
121b.b25x3 6.406674145
122b.l25x3 9.667569
123b.l25x6 12.7583418
124b.l27x1 11.64719
125b.l27x2 7.26833469
126b.b28x3 4.739547
127b.b28x4 9.17375466
128b.b28x6 8.70367569
129b.b28x7 5.6325479
130g.h2x11 10.25634106
131g.ctx3 7.63375409
132g.ctx6 3.76533506
133g.ctx14 5.81542479
134g.ctx15 7.98792479
135g.ctx16 5.16815978
1361x32 2.71667405
1371x42 3.13033506
1382x40 6.207627138
1392x42 5.23583408
1402x46 3.969675119
1412x51 4.03833407
1422x57 5.82611636
1432x61 5.87067536
1442x64 7.02417403
1452x65 6.46792404
1462x66 2.78404
1473x25 4.34033509
1483x36 5.15767536
1493x44 2.89125406
1503x49 6.8025409
1513x50 7.997924119
1523x56 6.99542405
153I2x53 7.467507
1544x46 4.568754228
1554x50 4.810424229
1564x58 4.70792404
1574x61 2.82917406
158E2.W172 4.21533505
159E2.F183 9.07533536
160E2.I186 3.58567535
1615x39 5.283507
1625x43 7.47139635
1635x50 3.36042407
1645x51 5.04537
1655x58 6.255566119
1665x73 0.4225404
167I3.H226 4.86208424
1686x48 6.54767538
1696x55 4.28792406
1707x34 5.95267534
1717x53 5.890836119
1728x49 4.6454136
173Lig 8.310121430
174H.HA.19 0.6791674180
175H.HC.03 0.3325180
176H.HC.07 0.5466674180
177H.HD.07 0.764167400
178H.hdhe.01 0.609722600
179H.HE.05 0.583500
180H.HE.06 0.715417400
181H.HF.06 0.99125400
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1b.l26x5 g.ctx4 16.00787.26833NoNo057
2g.ctx3 g.ctx4 16.64694.025YesNo097
3g.ctx3 g.ctx6 22.31938.595YesYes096
4b.l22x5 g.ctx6 29.73024.25YesYes096
5b.l22x5 b.l24x2 31.374710.1217YesNo1796
6b.h2x5 b.l24x2 31.67176.87833NoNo056
7b.h2x1 b.h2x5 31.80613.44YesNo055
8b.b21x5 b.h2x1 32.06557.775YesYes045
9b.b21x5 b.b21x7 33.271110.1783YesYes045
10b.b21x7 b.b24x6 39.67289.48667YesYes058
11b.b23x6 b.b24x6 39.77538.84167YesYes1478
12b.b23x6 b.l21x7 41.66743.35833YesNo1475
13b.l21x7 b.l23x1 42.5697.26333NoNo056
14b.l23x1 b.l25x6 42.902617.2717NoYes068
15G.H3.17 b.l25x6 42.59085.33333YesYes158
16G.H3.15 G.H3.17 44.75815.085NoYes185
17G.H2.08 G.H3.15 22.68763.53833NoNo188
18G.H2.04 G.H2.08 22.94693.75833YesNo098
19G.H2.04 G.H3.08 83.55443.64333YesNo099
20G.H3.08 G.S4.04 83.58145.685NoYes099
21G.S4.04 G.S5.04 78.50773.44833YesYes199
22G.S5.04 G.S5.06 1004.61167YesNo098
23G.S5.06 G.s4h3.01 51.53687.61NoNo087
24G.HG.04 G.s4h3.01 50.096213.8033YesNo097
25G.H4.03 G.HG.04 50.52943.785YesYes049
26G.H4.03 G.HG.01 98.24675.375YesNo045
27G.HG.01 G.s6h5.02 98.09273.77333NoYes057
28G.s6h5.02 G.s6h5.05 97.47572.33333YesYes079
29G.H5.03 G.s6h5.05 96.65516.05833YesYes089
30G.H5.03 G.S6.04 87.36933.40167YesNo289
31G.H5.06 G.S6.04 87.344620.93YesNo239
32G.H5.06 I3.H226 79.88044.90333YesYes234
33G.H5.05 I3.H226 78.91266.18333NoYes254
34G.H5.05 G.S2.08 78.80434.48667NoYes255
35G.H5.08 G.S2.08 75.20646.61YesYes285
36G.H5.08 G.S3.01 74.91735.88667YesYes284
37G.S3.01 I2x51 73.62326.295YesNo047
38G.H5.15 I2x51 74.15833.38833NoNo077
39G.H5.15 G.H5.19 73.98844.25NoNo078
40G.H5.19 I2x53 73.818313.18NoYes087
413x52 I2x53 12.1581.95NoYes057
423x52 3x56 11.9491.95NoYes055
43G.H3.15 G.H3.18 22.24993.22167NoYes189
44G.H3.18 G.S4.02 22.33578.37167YesYes198
45G.S4.02 G.S5.02 24.55873.67833YesNo186
46G.H3.09 G.S5.02 24.28735.86YesNo196
47G.H3.09 G.S5.04 22.95565.07667YesYes199
48G.S5.06 G.S6.05 48.46087.31NoNo084
49G.H4.07 G.S6.05 48.6343.92833NoNo054
50G.H4.03 G.H4.07 48.57794.00333YesNo045
51G.H2.04 G.H2.07 65.29214.5YesYes099
52G.H2.06 b.l9x6 64.3563.58YesYes198
53G.H2.06 b.l17x6 63.78518.065YesYes199
54b.l17x5 b.l17x6 64.13423.43667NoYes169
55b.l17x5 b.l19x2 64.20064.17167NoYes169
56b.l17x3 b.l19x2 63.54814.2YesYes199
57b.b20x6 b.l17x3 61.30924.53YesYes169
58b.b17x7 b.b20x6 59.892711.6117YesYes186
59b.b17x7 b.b21x1 59.58814.37833YesYes187
60b.1x19 b.b21x1 60.43079.13YesYes067
61b.1x15 b.1x19 58.97984.59333NoYes076
62b.1x15 g.h1x14 58.83815.01NoNo079
63b.b17x6 g.h1x14 29.92116.35167NoNo079
64b.b16x4 b.b17x6 29.854512.2617YesNo067
65b.b16x4 b.b16x6 28.64448.12YesYes568
66b.b15x1 b.b16x6 40.208912.8633YesYes598
67b.b14x5 b.b15x1 20.86733.65333NoYes059
68b.b10x4 b.b14x5 22.27233.23833NoNo065
69b.b10x4 b.b2x4 23.854412.415NoNo066
70b.b2x4 b.b6x5 23.68933.27NoYes066
71g.h1x10 g.h1x14 28.88275.09667NoNo099
72b.b17x3 g.h1x10 29.55876.10333NoNo059
73b.b16x6 b.b17x3 29.48616.31167YesNo585
74G.H2.07 b.l9x6 65.16476.43167YesYes198
75G.H5.10 G.S5.03 14.39324.33NoYes068
76G.H5.10 G.S6.02 14.04215.78333NoYes067
773x55 3x56 10.529620.5767NoYes065
782x46 3x42 11.76945.50667YesNo098
792x45 3x42 11.95534.34667NoNo098
802x45 4x46 12.12799.01NoYes2298
812x42 4x46 50.14823.855YesYes088
822x42 3x49 53.06064.77667YesYes089
833x49 I2x53 53.76649.96167YesYes097
84b.lhb1x11 g.ctx5 11.12915.655NoNo049
85b.l22x1 g.ctx5 11.41333.50167NoNo099
86b.b3x2 b.b4x6 11.14455.50333NoYes459
87b.b2x5 b.b3x2 11.19989.49167YesNo475
88b.b10x2 b.b6x2 21.60893.09833NoNo068
89b.b10x3 b.b6x2 21.39245.35167NoNo088
90b.b10x3 b.b11x2 14.40133.545NoYes087
91b.l26x1 b.l26x3 10.03858.19167NoNo477
92b.l26x3 b.l26x5 10.3346.7NoNo075
93b.b3x3 b.b6x5 15.48825.04667YesYes086
94b.b7x1 b.b8x3 12.34323.83167YesYes046
95b.b10x2 b.b14x3 19.27253.96667NoYes065
96b.b12x5 b.b13x4 19.02683.19167NoNo064
97b.b12x7 b.b13x4 18.80812.65333YesNo094
98b.b13x5 b.b13x7 17.59596.05333NoYes047
99b.b12x7 b.l12x3 18.15126.74667YesNo095
1005x43 Lig 25.113313.5167YesYes350
1013x37 5x43 33.57436.06333NoYes365
1023x37 4x53 36.92213.73333NoNo068
1033x38 4x53 37.11173.42NoNo078
1043x38 4x50 37.30297.34667NoYes079
1054x46 4x50 37.65424.555YesYes2289
106b.b13x2 b.l12x3 17.9322.125NoNo045
107H.hdhe.01 b.b13x2 17.70740.375YesNo004
108H.hdhe.01 H.hdhe.03 16.23180.39YesNo000
109H.HD.07 H.hdhe.03 15.81020.406667YesNo000
110b.b14x3 b.b15x1 19.30787.10667YesYes559
111b.b3x3 b.b4x3 14.44733.97333YesYes087
112b.b13x7 b.b16x6 17.591414.6983YesYes578
113b.b12x5 b.b13x5 17.38435.64833NoNo064
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
E2.P184NT.Y2512.51670NoNo0012
2x64NT.M266.011670YesNo3012
1x392x613.263NoYes6621
1x397x394.323NoNo6522
2x533x363.928330NoYes8621
2x572x615.5353YesYes6611
2x573x324.586673YesNo6511
2x573x364.823333YesYes6611
2x577x384.623333YesNo6511
2x577x425.886673YesNo6612
2x57Lig9.501673YesYes6010
2x603x285.8650NoNo4512
2x60Lig3.7650NoYes4010
2x612x6513.19833YesYes6412
2x617x393.523333YesNo6512
2x61Lig3.836673YesYes6010
2x643x253.930YesYes3912
2x64Lig10.80330YesYes3010
3x253x296.280YesNo9421
3x25E2.P1845.5350YesNo9021
3x29Lig6.571673NoYes4010
3x32Lig3.891673NoYes5010
3x334x575.063333NoNo4712
3x335x434.646673NoYes4511
3x33Lig10.96673NoYes4010
3x366x487.6853YesYes6812
3x367x415.353333YesNo6712
3x36Lig3.998333YesYes6010
3x375x436.063333NoYes6521
7x34E2.L1829.1353YesNo4012
E2.F183E2.I1863.768333YesYes0011
6x55E2.F1834.561670YesYes6021
7x34E2.F1835.8953YesYes4011
E2.F183Lig26.88673YesYes0010
E2.P184Lig5.511670NoYes0010
5x36E2.I1863.953330NoYes4021
5x39E2.I1863.426670YesYes7021
E2.I186Lig3.3453YesYes0010
5x395x434.981670YesYes7521
5x435x4711.74333YesNo5712
5x436x553.876673YesYes5612
5x43Lig13.51673YesYes5010
6x487x417.403333YesNo8722
6x547x345.481670NoYes4421
7x34Lig6.413333YesYes4010
7x38Lig7.333333NoYes5010
2x642x657.351670YesYes3412
3x29E2.I1863.4353NoYes4011
3x375x473.293333NoNo6722
E2.F183E2.L1824.2653YesNo0012
6x517x342.838330NoYes6421

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
92.31Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
91.67Single7V3ZCP559407V3Z-CB1-CP55940
85.71Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
85.71Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
83.33Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
80.00Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
78.57Single5XR8AM8415XR8-CB1-AM841
78.57Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
75.00Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
73.33Single9DGIZ85267113509DGI-CB1-Z8526711350
73.33Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
71.43Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
71.43Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
71.43Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
71.43Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
71.43Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
69.23Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
69.23Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
68.75Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
66.67Single5XRAAM115425XRA-CB1-AM11542
66.67Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
66.67Single7FEECP559407FEE-CB1-CP55940-ZCZ011
66.67Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
66.67Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
66.67Single9EGOYVF9EGO-CB1-YVF-Gi1/β1/γ2
64.71Single5ZTYAM102575ZTY-CB2-AM10257
64.71Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
64.29Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
62.50Single6KQICP559406KQI-CB1-CP55940-Org27569
62.50Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
62.50Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
61.11Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
58.82Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
58.82Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
58.82Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
57.14Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
56.25Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
53.33Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
53.33Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
52.94Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
52.94Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
52.94Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
52.94Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
52.63Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
52.63Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
50.00Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
50.00Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
50.00Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
50.00Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
50.00Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
50.00Single8JXSPF-61428JXS-D1-PF-6142
50.00Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
50.00Single9I52A1IZU9I52-D1-A1IZU-Gs/β1/γ2
50.00Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
50.00Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
47.62Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
47.37Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
47.37Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
47.37Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
47.06Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
47.06Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
47.06Single8E0GBU728E0G-μ-BU72
47.06Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
47.06Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
46.67Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
46.67Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
46.67Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
46.67Single8K5CAcipimox8K5C-HCA2-Acipimox
46.67Consensushca_onOrthosteric Ligandhca2_on
46.15Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
45.83Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
45.45Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
45.00Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
45.00Consensuslpl_onOrthosteric Ligands1p_on lpa_on
45.00Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
44.44Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
44.44Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
44.44Single7YITNalfurafine7YIT-κ-Nalfurafine
44.44Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
44.44Consensuslpl_offOrthosteric Ligands1p_off lpa_off
44.44Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
44.44Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
44.44Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
43.75Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
43.75Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
43.75Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
43.75Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
43.75Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
43.75Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
43.75Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
43.75Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
43.75Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
43.75Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
43.75Consensushca_on_gpOrthosteric Ligandhca2_on_gp
43.75Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
43.48Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
43.48Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
43.48Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
42.86Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
42.86Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
42.86Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
42.86Single8K5BNiacin8K5B-HCA2-Niacin
42.86Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
42.86Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
42.86Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
42.11Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
42.11Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
42.11Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
42.11Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
42.11Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
42.11Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
41.67Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
41.67Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
41.18Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
41.18Single5C1MBU725C1M-μ-BU72
41.18Single7C4SS1P7C4S-S1P3-S1P
41.18Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
41.18Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
41.18Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
41.18Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
41.18Single8TF5Oleic acid8TF5-GPR6-Oleic acid
41.18Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
41.18Single9CIBFCH-22964139CIB-HCA2-FCH-2296413
41.18Single9KPFSA09KPF-TAS2R16-SA0-Gi1/β1/γ2
41.18Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
41.18Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
41.18Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
41.18Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
40.91Single6W25SHU91196W25-MC4-SHU9119-Ca
40.91Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
40.91Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
40.91Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
40.00Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
40.00Single4UG2CGS216804UG2-A2A-CGS21680
40.00Single6AKXA4R6AKX-CCR5-A4R
40.00Single6AKYMaraviroc6AKY-CCR5-Maraviroc
40.00Single6B73MP11046B73-κ-MP1104
40.00Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
40.00Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
40.00Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
40.00Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
40.00Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
40.00Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
40.00Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
40.00Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
40.00Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
40.00Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
40.00Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
40.00Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
40.00Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
40.00Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
40.00Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
40.00Single8Y72Peptide8Y72-μ-Peptide-BMS-986122-Gi1/β1/γ2
40.00Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
40.00Single8YYWAlpha-ketoglutarate8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
40.00Single9K6LSA09K6L-TAS2R16-SA0-Gi2/β1/γ2
40.00Single9M0RNeuropeptide VF9M0R-NPFF1-Neuropeptide VF-Gi1/β1/γ2
40.00Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
40.00Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
40.00Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
40.00Consensusorexin_offOrthosteric Ligandox2_off ox1_off
40.00Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
40.00Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
40.00Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
40.00Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
40.00Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
40.00Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
40.00Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
40.00Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
39.13Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
39.13Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
39.13Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
39.13Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
39.13Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
39.13Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
38.89Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
38.89Single4DJHJDTic4DJH-κ-JDTic
38.89Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
38.89Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
38.89Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
38.89Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
38.89Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
38.89Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
38.89Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
38.89Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
38.89Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
38.89Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
38.89Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
38.89Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
38.89Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
38.89Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
38.89Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
38.89Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
38.89Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
38.89Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
38.89Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
38.89Single8Y73Peptide8Y73-μ-Peptide-MPAM-15-Gi1/β1/γ2
38.89Single9I54A1IZV9I54-D1-A1IZV-Gs/β1/γ2
38.89Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
38.89Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
38.89Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
38.89Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
38.89Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
38.89Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
38.10Single4XT1Fractalkine4XT1-US28-Fractalkine
38.10Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
38.10Single7QA8Peptide7QA8-STE2-Peptide
38.10Single7QA8Peptide7QA8-STE2-Peptide
38.10Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
38.10Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
38.10Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
38.10Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
37.50Single4MBSMaraviroc4MBS-CCR5-Maraviroc
37.50Single4ZJCSB-6740424ZJC-OX1-SB-674042
37.50Single6TPGEMPA6TPG-OX2-EMPA
37.50Single7F61PF-036547467F61-H3-PF-03654746
37.50Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
37.50Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
37.50Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
37.50Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
37.50Single8IHKAcifran8IHK-HCA3-Acifran
37.50Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
37.50Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
37.50Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
37.50Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
37.50Single8K9LDamgo8K9L-μ-Damgo-BMS-986122-Gi3/β1/γ1
37.50Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
37.50Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
37.50Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
37.50Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
37.50Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
37.50Single8ZRTET-18ZRT-ETB-ET-1
37.50Single9JMDAzithromycin9JMD-Motilin-Azithromycin-chim(Gs-CtGq)/β1/γ2
37.50Single9KPDSA09KPD-TAS2R16-SA0-chim(Gs-CtGt3)/β1/γ2
37.50Single9M2FNeuropeptide FF9M2F-NPFF1-Neuropeptide FF-Gi1/β1/γ2
37.50Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
36.84Single4RWADIPP-NH24RWA-δ-DIPP-NH2
36.84Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
36.84Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
36.84Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
36.84Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
36.84Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
36.84Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
36.84Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
36.84Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
36.84Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
36.84Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
36.84Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
36.84Single8XYIVUF106618XYI-CXCR3-VUF10661
36.84Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
36.84Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
36.84Single9M4QDoxazosin9M4Q-Alpha1A-Doxazosin
36.84Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
36.84Consensusalpha1_offOrthosteric Ligandalpha1a_off
36.84Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
36.84Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
36.84Consensuslpa_offOrthosteric Ligandlpa1_off
36.84Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
36.84Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
36.84Consensusorexin_onOrthosteric Ligandox2_on
36.84Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
36.36Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
36.36Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
36.36Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
36.36Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
36.36Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
36.36Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
36.36Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
36.00Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
36.00Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
36.00Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
35.71Single3OE6IT1t3OE6-CXCR4-IT1t
35.71Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
35.71Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
35.71Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
35.71Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
35.71Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
35.71Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
35.71Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
35.48Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
35.48Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
35.29Single2Y04Salbutamol2Y04-β1-Salbutamol
35.29Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
35.29Single4YAYZD-71554YAY-AT1-ZD-7155
35.29Single6TOTLemborexant6TOT-OX1-Lemborexant
35.29Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
35.29Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
35.29Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
35.29Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
35.29Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
35.29Single7UL4Alvimopan7UL4-μ-Alvimopan
35.29Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
35.29Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
35.29Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
35.29Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
35.29Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
35.29Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
35.29Single7YXAONO-54306087YXA-S1P5-ONO-5430608
35.29Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
35.29Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
35.29Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
35.29Single8JXRLSD8JXR-D1-LSD
35.29Single8K5DGSK2560738K5D-HCA2-GSK256073
35.29Single8PJKST1718PJK-5-HT1A-ST171-Gi1/β1/γ1
35.29Single8T1WCVN4248T1W-GPR6-CVN424
35.29Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
35.29Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
35.29Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
35.29Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
35.29Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
35.29Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
35.29Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
35.29Single9CHXS-Carazolol9CHX-β2-S-Carazolol
35.29Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
35.29Single9IZCMK19039IZC-HCA2-MK1903-Gi1/β1/γ2
35.29Single9KFJPubChem 1383196749KFJ-RXFP3-PubChem 138319674-Gi2/β1/γ2
35.29Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
35.29Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
35.29Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
35.29Consensusblt_onOrthosteric Ligandblt1_on
35.29Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
35.29Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
35.29Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
35.29Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
35.29Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
35.29Consensusleukotriene_onOrthosteric Ligandblt_on
35.29Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
35.00Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
35.00Single5X93K-87945X93-ETB-K-8794
35.00Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
35.00Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
35.00Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
35.00Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
35.00Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
35.00Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
35.00Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
35.00Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
35.00Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
35.00Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
35.00Single8ZWGJR14a8ZWG-C3aB-JR14a-Gi1/β1/γ2
35.00Single9M54Neuropeptide VF9M54-NPFF2-Neuropeptide VF-Gi1/β1/γ2
35.00Consensusendothelin_offOrthosteric Ligandetb_off
35.00Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
35.00Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
35.00Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
35.00Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
35.00Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
35.00Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
34.78Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
34.78Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
34.78Single8W8YGamma-MSH8W8Y-MC3-γ-MSH-Ca-Gs/β1/γ2
34.78Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
34.78Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
34.78Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
34.78Single9U4WGonadoliberin-19U4W-GnRH1-Gonadoliberin-1-chim(NtGi1L-Gs-CtGq)/β1/γ2
34.78Consensusangiotensin_onOrthosteric Ligandat1_on
34.78Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
34.62Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
34.62Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
34.62Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
34.62Consensusglp_onOrthosteric Ligandglp1_on glp2_on
34.62Consensusglp_on_gpOrthosteric Ligandglp1_on_gp glp2_on_gp
34.48Consensuscrf_on_gpOrthosteric Ligandcrf2_on_gp crf1_on_gp
34.48Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
34.38Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
33.33Single2Y03Isoprenaline2Y03-β1-Isoprenaline
33.33Single3NY9ICI118-5513NY9-β2-ICI118-551
33.33Single3OE9IT1t3OE9-CXCR4-IT1t
33.33Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
33.33Single5WQCEMPA5WQC-OX2-EMPA
33.33Single6IGLIRL16206IGL-ETB-IRL1620
33.33Single6JODAngiotensin II6JOD-AT2-Angiotensin II
33.33Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
33.33Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
33.33Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
33.33Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
33.33Single6TP6Filorexant6TP6-OX1-Filorexant
33.33Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
33.33Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
33.33Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
33.33Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
33.33Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
33.33Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
33.33Single7LD3Adenosine7LD3-A1-Adenosine-MIPS521-Gi2/β1/γ2
33.33Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
33.33Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
33.33Single7SK9CCX6627SK9-ACKR3-CCX662
33.33Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
33.33Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
33.33Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
33.33Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
33.33Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
33.33Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
33.33Single7XP6Strychnine7XP6-TAS2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
33.33Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
33.33Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
33.33Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
33.33Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
33.33Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
33.33Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
33.33Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
33.33Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
33.33Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
33.33Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
33.33Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
33.33Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
33.33Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
33.33Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
33.33Single8QJ2pN1628QJ2-MC4-pN162-Gs
33.33Single8S4DCMF-0198S4D-Apelin-CMF-019
33.33Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
33.33Single8XYKVUF106618XYK-CXCR3-VUF10661-Go/β1/γ2
33.33Single8ZBISomatostatin-148ZBI-SST3-Somatostatin-14-Gi1/β1/γ2
33.33Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
33.33Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
33.33Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single9EHSLUF76029EHS-A3A-LUF7602
33.33Single9F33FOB02-04A9F33-D3-FOB02-04A-Go/β1/γ2
33.33Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
33.33Single9IPVJR14a9IPV-C3aB-JR14a-Gi1/β1/γ2
33.33Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
33.33Single9IZASCH9002719IZA-HCA2-SCH900271-Gi1/β1/γ2
33.33Single9IZDCHBA9IZD-HCA1-CHBA-Gi1/β1/γ2
33.33Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
33.33Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
33.33Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
33.33Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
33.33Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
33.33Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
33.33Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
33.33Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
33.33Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
33.33Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
33.33Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
33.33Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
33.33Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
33.33Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
33.33Consensustrace-amine_onOrthosteric Ligandta1_on
32.35Consensuspth_on_gpOrthosteric Ligandpth1_on_gp pth2_on_gp
32.26Consensuspth_onOrthosteric Ligandpth1_on pth2_on
32.14Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
32.14Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
32.14Consensusclass-a_class-b1_cons_onOrthosteric Ligandclass-a_on class-b1_on
32.00Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
32.00Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
32.00Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
32.00Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
32.00Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
32.00Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
32.00Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
32.00Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
32.00Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
31.82Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
31.82Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
31.82Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
31.82Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
31.82Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
31.82Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
31.82Single8KIGSHU91198KIG-MC3-SHU9119-Ca
31.82Single8PKMBefiradol8PKM-5-HT1A-Befiradol-Gi1/β1/γ1
31.82Single8WDTphotoNECA8WDT-A2A-photoNECA
31.82Single8WKYPG-9348WKY-MC4-PG-934
31.82Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
31.82Single9BUYLM1899BUY-β2-LM189-Gi1/β1/γ2
31.82Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
31.82Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
31.82Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
31.82Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
31.82Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
31.58Single2YDVNECA2YDV-A2A-NECA
31.58Single3P0GBI1671073P0G-β2-BI167107
31.58Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
31.58Single4UHRCGS216804UHR-A2A-CGS21680
31.58Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
31.58Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
31.58Single5G53NECA5G53-A2A-NECA-Gs
31.58Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
31.58Single6H7JIsoprenaline6H7J-β1-Isoprenaline
31.58Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
31.58Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
31.58Single6TQ7SB-3348676TQ7-OX1-SB-334867
31.58Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
31.58Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
31.58Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
31.58Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
31.58Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
31.58Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
31.58Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
31.58Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
31.58Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
31.58Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
31.58Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
31.58Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
31.58Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
31.58Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
31.58Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
31.58Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
31.58Single9BJKNaloxone9BJK-μ-Naloxone-NAM
31.58Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
31.58Single9JMCDS-3801b9JMC-Motilin-DS-3801b-chim(Gs-CtGq)/β1/γ2
31.58Single9UY3Anamorelin9UY3-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
31.58Consensusa2_onOrthosteric Liganda2b_on
31.58Consensusa2_on_gpOrthosteric Liganda2b_on_gp
31.58Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
31.58Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
31.58Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
31.58Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
31.58Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
31.58Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
31.58Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
31.58Consensuslpa_onOrthosteric Ligandlpa1_on
31.58Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
31.58Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
31.58Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
31.58Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
31.25Single3ODUIT1t3ODU-CXCR4-IT1t
31.25Single5WS3EMPA5WS3-OX2-EMPA
31.25Single5ZKQABT-4915ZKQ-PAF-ABT-491
31.25Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
31.25Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
31.25Single6TODEMPA6TOD-OX1-EMPA-Na
31.25Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
31.25Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
31.25Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
31.25Single7XRRLemborexant7XRR-OX2-Lemborexant
31.25Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
31.25Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
31.25Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.25Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
31.25Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
31.25Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
31.25Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
31.25Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
31.25Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
31.25Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
31.25Single8Y0HVUF114188Y0H-CXCR3-VUF11418
31.25Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go/β1/γ2
31.25Single9KPESA09KPE-TAS2R16-SA0-Gi1/β1/γ2
31.25Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
31.25Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
31.25Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
31.25Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
31.03Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
31.03Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
30.77Single4XT3Fractalkine4XT3-US28-Fractalkine
30.77Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
30.77Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
30.77Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
30.77Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
30.77Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
30.77Single9KFKRelaxin-39KFK-RXFP4-Relaxin-3-Gi2/β1/γ2
30.77Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
30.77Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
30.77Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
30.77Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
30.43Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
30.43Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
30.43Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
30.43Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
30.43Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
30.43Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
30.43Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
30.43Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
30.43Single9E82SDF-1-beta9E82-ACKR3-SDF-1-β-Arrestin2
30.43Single9IQVMuscarinic toxin 39IQV-Alpha1A-Muscarinic toxin 3
30.43Single9J0FNADH9J0F-P2Y14-NADH-Gi1/β1/γ2
30.43Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
30.43Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
30.43Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
30.43Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
30.43Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
30.43Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
30.43Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
30.43Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
30.43Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
30.43Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
30.00Single4LDEBI1671074LDE-β2-BI167107
30.00Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
30.00Single6A93Risperidone6A93-5-HT2A-Risperidone
30.00Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
30.00Single6MXTSalmeterol6MXT-β2-Salmeterol
30.00Single6ZG4HTL00099366ZG4-M1-HTL0009936
30.00Single7DFPSpiperone7DFP-D2-Spiperone
30.00Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
30.00Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
30.00Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
30.00Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
30.00Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
30.00Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
30.00Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
30.00Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
30.00Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
30.00Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
30.00Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
30.00Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
30.00Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
30.00Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
30.00Single8JJ8Formoterol8JJ8-β2-Formoterol
30.00Single8JJLOlodaterol8JJL-β2-Olodaterol
30.00Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
30.00Single8XJNCloprosetnol8XJN-TXA2-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
30.00Single9GGGI-BOP9GGG-TXA2-I-BOP-chim(NtGi2L-Gs-CtGq)/β1/γ2
30.00Single9GL2Befiradol9GL2-5-HT1A-Befiradol-Gs/β1/γ2
30.00Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
30.00Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
30.00Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
30.00Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
30.00Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
30.00Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
30.00Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
30.00Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
30.00Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
30.00Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
29.73Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
29.63Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
29.63Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
29.63Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
29.63Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
29.63Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
29.63Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
29.63Single8W8WAlpha-MSH8W8W-MC3-α-MSH-Ca-Gs/β1/γ2
29.63Single8W8XBeta-MSH8W8X-MC3-β-MSH-Ca-Gs/β1/γ2
29.63Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
29.63Single9KDFRES-701-39KDF-ETB-RES-701-3
29.63Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
29.63Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
29.63Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
29.41Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
29.41Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
29.41Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
29.41Single6PS0S-Carazolol6PS0-β2-S-Carazolol
29.41Single6PS4ICI118-5516PS4-β2-ICI118-551
29.41Single6PS5S-Propranolol6PS5-β2-S-Propranolol
29.41Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
29.41Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
29.41Single6TPNHTL66416TPN-OX2-HTL6641
29.41Single6VI4JDTic6VI4-κ-JDTic
29.41Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
29.41Single6ZG9GSK10347026ZG9-M1-GSK1034702
29.41Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
29.41Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
29.41Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
29.41Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
29.41Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
29.41Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
29.41Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
29.41Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
29.41Single7UL3Famotidine7UL3-H2-Famotidine
29.41Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
29.41Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
29.41Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
29.41Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
29.41Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
29.41Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
29.41Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
29.41Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
29.41Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.41Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.41Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
29.41Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
29.41Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
29.41Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
29.41Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
29.41Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
29.41Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
29.41Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
29.41Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
29.41Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
29.41Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
29.41Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.41Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.41Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
29.41Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
29.41Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
29.41Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
29.41Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
29.41Single8Y6YGLPG09748Y6Y-FFA2-GLPG0974
29.41Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
29.41Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
29.41Single9JFUNE52-QQ579JFU-GPR4-NE52-QQ57
29.41Single9JH3CMF-0199JH3-Apelin-CMF-019-Gi1/β1/γ2
29.41Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
29.41Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
29.41Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
29.41Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
29.41Consensusalpha1_onOrthosteric Ligandalpha1a_on
29.41Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
29.41Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
29.41Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
29.41Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
29.41Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
29.41Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
29.41Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
29.41Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
29.17Single6PT2KGCHM076PT2-δ-KGCHM07
29.17Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
29.17Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
29.17Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
29.17Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
29.17Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
29.17Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
29.17Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
29.17Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
29.17Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
29.17Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
29.17Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
29.03Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
29.03Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
29.03Consensusclass-a_class-b1_cons_on_gpOrthosteric Ligandclass-a_on_gp class-b1_on_gp
28.57Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
28.57Single3OE8IT1t3OE8-CXCR4-IT1t
28.57Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
28.57Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
28.57Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
28.57Single6K1QIRL25006K1Q-ETB-IRL2500
28.57Single6TQ9SB-4081246TQ9-OX1-SB-408124
28.57Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
28.57Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
28.57Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
28.57Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
28.57Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
28.57Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
28.57Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
28.57Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
28.57Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
28.57Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
28.57Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
28.57Single7UM4AS26747237UM4-5-HT5A-AS2674723
28.57Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
28.57Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
28.57Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
28.57Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
28.57Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
28.57Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
28.57Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
28.57Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
28.57Single8IWM2-Phenylethylamine8IWM-TA9-2-Phenylethylamine
28.57Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
28.57Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
28.57Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
28.57Single8S2TIsoprenaline8S2T-β1-Isoprenaline-chim(NtGi1-Gs)/β1/γ2
28.57Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
28.57Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
28.57Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Single8XJOU466198XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Single9BYOExendin-39BYO-GLP-1-Exendin-3-Gs/β1/γ2
28.57Single9CHUNoradrenaline9CHU-β2-Noradrenaline
28.57Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
28.57Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
28.57Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
28.57Consensuscck_onOrthosteric Ligandccka_on cckb_on
28.57Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
28.57Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
28.57Consensusgs_histamineOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
28.57Consensush2_onOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
28.57Consensusprostanoid_offOrthosteric Ligandep_off dp_off
28.57Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
28.57Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
28.57Consensustp_onOrthosteric Ligand8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Consensustp_on_gpOrthosteric Ligand8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
28.12Consensusglucagon_on_gpOrthosteric Ligandglp_on_gp gluc_on_gp secretin_on_gp gip_on_gp
28.00Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
28.00Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
28.00Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
28.00Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
28.00Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
28.00Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
28.00Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ2
28.00Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
28.00Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
28.00Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
28.00Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
27.78Single3NY8ICI118-5513NY8-β2-ICI118-551
27.78Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
27.78Single4EJ4Naltrindole4EJ4-δ-Naltrindole
27.78Single4GBRS-Carazolol4GBR-β2-S-Carazolol
27.78Single4QKX35V4QKX-β2-35V
27.78Single5DHGC-355DHG-NOP-C-35
27.78Single5DHHSB-6121115DHH-NOP-SB-612111
27.78Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
27.78Single5TGZAM65385TGZ-CB1-AM6538
27.78Single6DRXLisuride6DRX-5-HT2B-Lisuride
27.78Single6GPSMK08126GPS-CCR2-MK0812
27.78Single6H7MSalbutamol6H7M-β1-Salbutamol
27.78Single6IIVDaltroban6IIV-TXA2-Daltroban
27.78Single6PS1Timolol6PS1-β2-Timolol
27.78Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
27.78Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
27.78Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
27.78Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
27.78Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
27.78Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
27.78Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
27.78Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
27.78Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
27.78Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
27.78Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
27.78Single7WC7Lisuride7WC7-5-HT2A-Lisuride
27.78Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
27.78Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
27.78Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
27.78Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
27.78Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
27.78Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
27.78Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
27.78Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
27.78Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.78Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.78Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.78Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.78Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.78Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.78Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.78Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.78Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.78Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.78Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
27.78Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
27.78Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
27.78Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
27.78Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
27.78Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
27.78Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
27.78Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
27.78Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
27.78Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
27.78Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
27.78Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
27.78Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.78Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.78Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.78Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.78Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
27.78Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
27.78Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
27.78Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
27.78Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
27.78Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
27.78Single9PLNN-(5-methylnaphthalen-1-yl)pyridin-4-amine9PLN-α2a-N-(5-methylnaphthalen-1-yl)pyridin-4-amine
27.78Single9PLON-(5-methylnaphthalen-1-yl)pyridin-4-amine9PLO-α2a-N-(5-methylnaphthalen-1-yl)pyridin-4-amine-Go/β1/γ2
27.78Single9PQD(6m)-1-methyl-6-(1,2,5,6-tetrahydropyridin-3-yl)-1h-indole9PQD-α2a-(6m)-1-methyl-6-(1,2,5,6-tetrahydropyridin-3-yl)-1h-indole
27.78Consensus5ht5_onOrthosteric Ligand5ht5a_on
27.78Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
27.78Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
27.78Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
27.78Consensusa3_onOrthosteric Liganda3a_on
27.78Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
27.78Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
27.78Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
27.78Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
27.78Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
27.78Consensusdopamine_offOrthosteric Ligandd2_off d3_off
27.78Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
27.78Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
27.78Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
27.78Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
27.78Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
27.78Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
27.59Single5GLHEndothelin-15GLH-ETB-Endothelin-1
27.59Single6IGKEndothelin-36IGK-ETB-Endothelin-3
27.59Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
27.59Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
27.59Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
27.59Consensusbombesin_onOrthosteric Ligandbb2_on
27.59Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
27.59Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
27.59Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
27.59Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
27.59Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
27.27Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
27.27Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
27.27Single6PT3DPI-2876PT3-δ-DPI-287
27.27Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
27.27Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
27.27Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
27.27Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
27.27Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
27.27Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
27.27Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
27.27Single8X5YAstemizole8X5Y-H1-Astemizole
27.27Single9CGKC5-Quino9CGK-δ-C5-Quino-Gi1/β1/γ2
27.27Single9IPYJR14a9IPY-C3aB-JR14a
27.27Single9V2NMacimorelin9V2N-Ghrelin-Macimorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
27.27Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
27.27Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
27.27Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
26.92Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
26.92Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
26.92Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
26.92Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
26.92Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
26.92Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
26.92Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
26.92Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
26.92Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
26.92Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
26.92Single9JFYhNPSF9JFY-NPFF2-hNPSF-Gi1/β1/γ2
26.92Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
26.92Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
26.92Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
26.67Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
26.67Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
26.67Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
26.67Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
26.67Single8IW72-Phenylethylamine8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
26.67Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
26.67Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
26.67Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
26.67Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
26.67Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
26.67Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
26.67Single9LRCHistamine9LRC-H4-Histamine
26.67Single9LREHistamine9LRE-H4-Histamine-Gi1/β1/γ2
26.67Consensus5ht2_onOrthosteric Ligand5ht2b_on
26.67Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
26.67Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
26.67Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
26.67Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
26.32Single2RH1S-Carazolol2RH1-β2-S-Carazolol
26.32Single2YCWS-Carazolol2YCW-β1-S-Carazolol
26.32Single5D6LS-Carazolol5D6L-β2-S-Carazolol
26.32Single5JQHS-Carazolol5JQH-β2-S-Carazolol
26.32Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
26.32Single5TVNLSD5TVN-5-HT2B-LSD
26.32Single5WIUNemonapride5WIU-D4-Nemonapride
26.32Single5WIVNemonapride5WIV-D4-Nemonapride-Na
26.32Single5X7DS-Carazolol5X7D-β2-S-Carazolol-Cmpd-15
26.32Single5XPRBosentan5XPR-ETB-Bosentan
26.32Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
26.32Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
26.32Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
26.32Single6D26Fevipiprant6D26-DP2-Fevipiprant
26.32Single6E67BI1671076E67-β2-BI167107-Gs(CT)
26.32Single6GPXMK08126GPX-CCR2-MK0812
26.32Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
26.32Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
26.32Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
26.32Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
26.32Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
26.32Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
26.32Single7C61Ergotamine7C61-5-HT1B-Ergotamine
26.32Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
26.32Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
26.32Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
26.32Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
26.32Single7WC6LSD7WC6-5-HT2A-LSD
26.32Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
26.32Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
26.32Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
26.32Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
26.32Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.32Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.32Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
26.32Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
26.32Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
26.32Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
26.32Single8WGBVU01550418WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
26.32Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
26.32Single8ZVZBW245C8ZVZ-DP1-BW245C-Gs/β1/γ2
26.32Single9ARZ2-bromo-LSD9ARZ-5-HT2A-2-bromo-LSD
26.32Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
26.32Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
26.32Single9EE8Adenosine9EE8-A2A-Adenosine-Gs/β1/γ2
26.32Single9F34FOB02-04A9F34-D3-FOB02-04A-Go/β1/γ2
26.32Single9GE2ML1849GE2-GPR55-ML184-chim(NtGi1-G13)/β1/γ2
26.32Single9HAPTolvaptan9HAP-V2-Tolvaptan
26.32Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
26.32Single9K07DSO-5a9K07-BB3-DSO-5a-chim(NtGi2L-Gs-CtGq)/β1/γ2
26.32Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
26.32Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
26.32Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
26.32Consensusa3_on_gpOrthosteric Liganda3a_on_gp
26.32Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
26.32Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
26.32Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
26.32Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
26.32Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
26.32Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
26.32Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
26.32Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
26.32Consensusamine_offonOrthosteric Ligandamine_off amine_on
26.32Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
26.32Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
26.32Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
26.32Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
26.32Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
26.32Consensusblt_offOrthosteric Ligandblt1_off
26.32Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
26.32Consensusdp_offOrthosteric Liganddp2_off
26.32Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
26.32Consensusep_offOrthosteric Ligandep4_off
26.32Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
26.32Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
26.32Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
26.32Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
26.32Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
26.32Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
26.32Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
26.32Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
26.32Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
26.09Single4IARErgotamine4IAR-5-HT1B-Ergotamine
26.09Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
26.09Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
26.09Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
26.09Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
26.09Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
26.09Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
26.09Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
26.09Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
26.09Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
26.09Single8U4OCXCL128U4O-CXCR4-CXCL12-Gi1/β1/γ2
26.09Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
26.09Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
26.09Single8YWFRetatrutide8YWF-GLP-1-Retatrutide-chim(NtGi1-Gs)/β1/γ2
26.09Single9HB3Mambaquaretin-19HB3-V2-Mambaquaretin-1
26.09Single9J0IUDP-Glucuronic acid9J0I-P2Y14-UDP-Glucuronic acid-Gi1/β1/γ2
26.09Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
26.09Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
26.09Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
26.09Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
26.09Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
26.09Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
26.09Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
25.93Single6FJ3PTH6FJ3-PTH1-PTH
25.93Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
25.93Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
25.93Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
25.93Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
25.93Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
25.93Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
25.93Consensuspac_on_gpOrthosteric Ligandpac1_on_gp
25.81Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
25.81Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
25.81Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
25.00Single3QAKUK-4320973QAK-A2A-UK-432097
25.00Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
25.00Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
25.00Single4U15Tiotropium4U15-M3-Tiotropium
25.00Single5D5AS-Carazolol5D5A-β2-S-Carazolol
25.00Single5D5BS-Carazolol5D5B-β2-S-Carazolol
25.00Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
25.00Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
25.00Single6HLOAprepitant6HLO-NK1-Aprepitant
25.00Single6J21Aprepitant6J21-NK1-Aprepitant
25.00Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
25.00Single6OL9Tiotropium6OL9-M5-Tiotropium
25.00Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
25.00Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
25.00Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
25.00Single6WGTLSD6WGT-5-HT2A-LSD
25.00Single7B6WCyclazosin7B6W-α1b-Cyclazosin
25.00Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
25.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
25.00Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
25.00Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
25.00Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
25.00Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
25.00Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
25.00Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
25.00Single7SRQLSD7SRQ-5-HT2B-LSD
25.00Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
25.00Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
25.00Single7TUYGSK682753A7TUY-GPR183-GSK682753A
25.00Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
25.00Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
25.00Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
25.00Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
25.00Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
25.00Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
25.00Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Single7XNACYN1548067XNA-SST2-CYN154806
25.00Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
25.00Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
25.00Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
25.00Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
25.00Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
25.00Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
25.00Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
25.00Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
25.00Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
25.00Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
25.00Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
25.00Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
25.00Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
25.00Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
25.00Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
25.00Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
25.00Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
25.00Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
25.00Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
25.00Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
25.00Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
25.00Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
25.00Single8XVLZibotentan8XVL-ETA-Zibotentan
25.00Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
25.00Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
25.00Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
25.00Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
25.00Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
25.00Single8YN7Immethridine8YN7-H3-Immethridine-Go/β1/γ2
25.00Single8YNTSNAP-948478YNT-MCH1-SNAP-94847
25.00Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
25.00Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
25.00Single8ZW0PGD28ZW0-DP1-PGD2-Gs/β1/γ2
25.00Single8ZWFJR14a8ZWF-C3aB-JR14a
25.00Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
25.00Single9B9Y7DY9B9Y-CB1-7DY
25.00Single9IK8SST analogue9IK8-SST1-SST analogue-Gi1/β1/γ2
25.00Single9IK9SST analogue9IK9-SST1-SST analogue-Gi1/β1/γ2
25.00Single9IXJHistamine9IXJ-H2-Histamine-Gs/β1/γ2
25.00Single9KFIRelaxin-39KFI-RXFP3-Relaxin-3-Gi2/β1/γ2
25.00Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
25.00Single9LMPNE52-QQ579LMP-GPR4-NE52-QQ57
25.00Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
25.00Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
25.00Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
25.00Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
25.00Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
25.00Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
25.00Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
25.00Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
25.00Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
25.00Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
25.00Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
25.00Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
25.00Consensusglucagon_onOrthosteric Ligandglp_on gluc_on secretin_on gip_on
25.00Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
25.00Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
25.00Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
25.00Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
25.00Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
25.00Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
25.00Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
25.00Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
25.00Consensusrelaxin_onOrthosteric Ligandrxfp4_on
25.00Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
25.00Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
25.00Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
24.24Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
24.14Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
24.14Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
24.14Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
24.14Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
24.14Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
24.14Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
24.14Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
24.14Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
24.14Consensusbradykinin_onOrthosteric Ligandbk2_on
24.14Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
24.14Consensusendothelin_onOrthosteric Ligandetb_on eta_on
24.14Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
24.14Consensusvip-pacap_onOrthosteric Ligandvpac_on pac_on
24.14Consensusvip-pacap_on_gpOrthosteric Ligandvpac_on_gp pac_on_gp
24.00Single3OE0CVX153OE0-CXCR4-CVX15
24.00Single5WF5UK-4320975WF5-A2A-UK-432097
24.00Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
24.00Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
24.00Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
24.00Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
24.00Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
24.00Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
24.00Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
24.00Single9B5YLong-Acting PTH9B5Y-PTH1-Long-Acting PTH-chim(NtGi1-Gq)/β1/γ2
24.00Single9M1OMorphine-Modulating Neuropeptide B9M1O-NPFF2-Morphine-Modulating Neuropeptide B-Gi1/β1/γ2
24.00Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
24.00Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
24.00Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
24.00Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
24.00Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
24.00Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
24.00Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
24.00Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
23.81Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
23.81Single3D4STimolol3D4S-β2-Timolol
23.81Single4AMIBucindolol4AMI-β1-Bucindolol
23.81Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
23.81Single4PY02MeSATP4PY0-P2Y12-2MeSATP
23.81Single5CXVTiotropium5CXV-M1-Tiotropium
23.81Single5TZYMK8666; AP85TZY-FFA1-MK8666; AP8
23.81Single5X33BIIL2605X33-BLT1-BIIL260
23.81Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
23.81Single6CM4Risperidone6CM4-D2-Risperidone
23.81Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
23.81Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
23.81Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
23.81Single6IIURamatroban6IIU-TXA2-Ramatroban
23.81Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
23.81Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
23.81Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
23.81Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
23.81Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
23.81Single7K15MKD0467K15-BLT1-MKD046-Na
23.81Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
23.81Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
23.81Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
23.81Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
23.81Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.81Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
23.81Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
23.81Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
23.81Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
23.81Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
23.81Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
23.81Single8JWY2-1188JWY-A2A-2-118
23.81Single8JWZAB9288JWZ-A2A-AB928-Na
23.81Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
23.81Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
23.81Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
23.81Single9AU0BW245C9AU0-DP1-BW245C-Gs/β1/γ2
23.81Single9BJKNAM9BJK-μ-Naloxone-NAM
23.81Single9EBIPiclidenoson9EBI-A3A-Piclidenoson-chim(NtGi1L-Gs-CtGi1)/β1/γ2
23.81Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
23.81Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
23.81Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
23.81Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
23.81Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
23.81Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
23.81Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
23.81Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
23.81Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
23.81Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
23.81Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
23.81Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
23.81Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
23.81Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
23.81Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
23.53Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
23.53Single3PWHZM-2413853PWH-A2A-ZM-241385
23.53Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
23.53Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
23.53Single4S0VSuvorexant4S0V-OX2-Suvorexant
23.53Single5U09Taranabant5U09-CB1-Taranabant
23.53Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
23.53Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
23.53Single6ME2Ramelteon6ME2-MT1-Ramelteon
23.53Single6TPJSuvorexant6TPJ-OX2-Suvorexant
23.53Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
23.53Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
23.53Single7F8YDevazepide7F8Y-CCKA-Devazepide
23.53Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
23.53Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
23.53Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.53Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.53Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
23.53Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
23.53Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
23.53Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
23.53Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
23.53Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
23.53Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
23.53Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
23.53Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
23.53Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
23.53Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
23.53Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
23.53Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
23.53Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
23.53Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
23.53Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
23.53Single8GNGIstradefylline8GNG-A2A-Istradefylline
23.53Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
23.53Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
23.53Single8IWESpermidine8IWE-TA9-Spermidine
23.53Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
23.53Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
23.53Single8U4PAMD31008U4P-CXCR4-AMD3100-Gi1/β1/γ2
23.53Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.53Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.53Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.53Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
23.53Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
23.53Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ2
23.53Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
23.53Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
23.53Single9EBHAdenosine9EBH-A3A-Adenosine-Gi1/β1/γ2
23.53Single9EEAAdenosine9EEA-A2A-Adenosine-Gs/β1/γ2
23.53Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
23.53Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
23.53Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
23.53Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.53Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
23.53Consensusalpha2_offOrthosteric Ligandalpha2c_off
23.53Consensusangiotensin_offOrthosteric Ligandat1_off
23.53Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
23.53Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
23.53Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
23.53Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
23.53Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
23.53Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
23.53Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
23.33Single7RBTTirzepatide7RBT-GIP-Tirzepatide-LSN3556672-chim(NtGi1-Gs)/β1/γ2
23.33Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
23.33Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
23.33Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
23.08Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
23.08Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
23.08Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
23.08Single8GEJConstrained Epinephrine8GEJ-β2-Constrained Epinephrine-Gs/β1/γ2
23.08Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
23.08Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
23.08Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
23.08Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
23.08Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
23.08Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
23.08Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
23.08Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
23.08Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
23.08Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
23.08Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
23.08Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
23.08Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
23.08Consensusvasop-oxy_onOrthosteric Ligandv2_on
23.08Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
22.86Consensusclass-b1_onOrthosteric Ligandglucagon_on vip-pacap_on pth_on crf_on calcitonin_on
22.86Consensuspth2_on_gpOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
22.73Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
22.73Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
22.73Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
22.73Single6H7LDobutamine6H7L-β1-Dobutamine
22.73Single6IBLArformoterol6IBL-β1-Arformoterol
22.73Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
22.73Single7EZCUKA7EZC-A2A-UKA
22.73Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
22.73Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
22.73Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
22.73Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.73Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
22.73Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
22.73Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
22.73Single8XVJMacitentan8XVJ-ETA-Macitentan
22.73Single8ZPLHF511168ZPL-CXCR4-HF51116
22.73Single9AS02-bromo-LSD9AS0-5-HT2A-2-bromo-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73Single9CGJC6-Quino9CGJ-δ-C6-Quino-Gi1/β1/γ2
22.73Single9DYEBuspirone9DYE-5-HT1A-Buspirone-Go/β1/γ2
22.73Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
22.73Single9GG5U466199GG5-TXA2-U46619-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.73Single9M1HProstaglandin E29M1H-EP1-Prostaglandin E2-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
22.73Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
22.73Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
22.73Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
22.73Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
22.73Consensuschemerin_onOrthosteric Ligandcml1_on
22.73Consensusfp-alpha_onOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.73Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.73Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
22.58Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
22.58Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
22.58Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
22.58Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
22.22Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
22.22Single2YDOAdenosine2YDO-A2A-Adenosine
22.22Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
22.22Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
22.22Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
22.22Single6A94Zotepine6A94-5-HT2A-Zotepine
22.22Single6IQLL7458706IQL-D4-L745870
22.22Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
22.22Single6KUXRS-799486KUX-α2a-RS-79948
22.22Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
22.22Single6TP3Nemorexant6TP3-OX1-Nemorexant
22.22Single6V9SGTPL114036V9S-OX1-GTPL11403
22.22Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
22.22Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
22.22Single7AROLUF58337ARO-A2A-LUF5833-Na
22.22Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
22.22Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
22.22Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
22.22Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
22.22Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
22.22Single7T32ZM-2413857T32-A2A-ZM-241385
22.22Single7T94Acetylcholine7T94-M2-Acetylcholine-LY2119620-chim(NtGi1-Go)/β1/γ2
22.22Single7T94LY21196207T94-M2-Acetylcholine-LY2119620-chim(NtGi1-Go)/β1/γ2
22.22Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
22.22Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
22.22Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
22.22Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
22.22Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
22.22Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
22.22Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
22.22Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.22Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
22.22Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
22.22Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
22.22Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
22.22Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
22.22Single8K2WAMG4878K2W-CXCR3-AMG487
22.22Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
22.22Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
22.22Single8RLNLUF58348RLN-A2A-LUF5834
22.22Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
22.22Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
22.22Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
22.22Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
22.22Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
22.22Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
22.22Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
22.22Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.22Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
22.22Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
22.22Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
22.22Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
22.22Single8YRGFospropofol8YRG-MRGPRX4-Fospropofol-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
22.22Single8ZPMAMD0708ZPM-CXCR4-AMD070
22.22Single8ZPNAMD31008ZPN-CXCR4-AMD3100
22.22Single9ARXSerotonin9ARX-5-HT2A-Serotonin
22.22Single9AS5Mescaline9AS5-5-HT2A-Mescaline
22.22Single9AS6Mescaline9AS6-5-HT2A-Mescaline-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
22.22Single9BA0A1AKN9BA0-CB1-A1AKN
22.22Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
22.22Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
22.22Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
22.22Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
22.22Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
22.22Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
22.22Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
22.22Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
22.22Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
22.22Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
22.22Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
22.22Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
22.22Consensuspac_onOrthosteric Ligandpac1_on
22.22Consensusvpac_onOrthosteric Ligandvpac1_on vpac2_on
21.88Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
21.88Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
21.74Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
21.74Single5WF6UK-4320975WF6-A2A-UK-432097
21.74Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
21.74Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
21.74Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
21.74Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
21.74Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
21.74Single7XN9L-054,5227XN9-SST2-L-054,522
21.74Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
21.74Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
21.74Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
21.74Single9JH6C20:0 Ceramide9JH6-CysLT2-C20:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Single9MD1Buspirone9MD1-5-HT1A-Buspirone-Gz/β1/γ2
21.74Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
21.74Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
21.74Consensuskisspeptin_onOrthosteric Ligandkiss1_on
21.74Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
21.74Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
21.43Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
21.43Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
21.43Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
21.43Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
21.43Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
21.43Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
21.43Single7SK3CXCL127SK3-ACKR3-CXCL12
21.43Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
21.43Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
21.43Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
21.43Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
21.43Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
21.43Consensussecretin_onOrthosteric Ligand7D3S-Secretin-Secretin-Gs/β1/γ2
21.43Consensusvpac_on_gpOrthosteric Ligandvpac1_on_gp vpac2_on_gp
21.21Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
21.21Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
21.05Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
21.05Single2Y01Dobutamine2Y01-β1-Dobutamine
21.05Single2Y02Carmoterol2Y02-β1-Carmoterol
21.05Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
21.05Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
21.05Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
21.05Single4DAJTiotropium4DAJ-M3-Tiotropium
21.05Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
21.05Single4MQSIperoxo4MQS-M2-Iperoxo
21.05Single4U14Tiotropium4U14-M3-Tiotropium
21.05Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
21.05Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
21.05Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
21.05Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
21.05Single5UENDU1725UEN-A1-DU172
21.05Single5UIGCmpd-15UIG-A2A-Cmpd-1
21.05Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
21.05Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
21.05Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
21.05Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
21.05Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
21.05Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/β1/γ2
21.05Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
21.05Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
21.05Single7BU7BI1671077BU7-β1-BI167107
21.05Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
21.05Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
21.05Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
21.05Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
21.05Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
21.05Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
21.05Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
21.05Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
21.05Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
21.05Single8CU6LJ-45178CU6-A2A-LJ-4517
21.05Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
21.05Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
21.05Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
21.05Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
21.05Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
21.05Single8JJOAlprenolol8JJO-β2-Alprenolol
21.05Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
21.05Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
21.05Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
21.05Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
21.05Single8X63Mepyramine8X63-H1-Mepyramine
21.05Single8X64Desloratadine8X64-H1-Desloratadine
21.05Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
21.05Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
21.05Single8YN8Proxyfan8YN8-H3-Proxyfan-Go/β1/γ2
21.05Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
21.05Single9AS1DMT9AS1-5-HT2A-DMT
21.05Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
21.05Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
21.05Single9H37A1IR09H37-A2A-A1IR0-Na
21.05Single9IYAONO-97105319IYA-GPR55-ONO-9710531
21.05Single9JEAAtropine9JEA-M1-Atropine
21.05Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
21.05Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
21.05Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
21.05Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
21.05Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
21.05Consensusalpha2_onOrthosteric Ligandalpha2b_on
21.05Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
21.05Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
21.05Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
21.05Consensuscck_offOrthosteric Ligandccka_off
21.05Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
21.05Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
21.05Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
21.05Consensushistamine_offOrthosteric Ligandh1_off
21.05Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
21.05Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
21.05Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
21.05Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
20.83Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
20.83Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
20.83Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
20.83Single7F8XNN90567F8X-CCKA-NN9056
20.83Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
20.83Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
20.83Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
20.83Single8IEBA1LYA8IEB-GPR156-A1LYA
20.83Single8IEIA1LYA8IEI-GPR156-A1LYA
20.83Single8IEIA1LYA8IEI-GPR156-A1LYA
20.83Single8IEPA1LYA8IEP-GPR156-A1LYA
20.83Single8IEPA1LYA8IEP-GPR156-A1LYA
20.83Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
20.83Single8ZBJSomatostatin-148ZBJ-SST5-Somatostatin-14-Gi1/β1/γ2
20.83Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
20.83Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
20.83Single9M4TSilodosin9M4T-Alpha1A-Silodosin
20.83Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
20.83Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
20.83Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
20.83Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
20.83Consensussomatostatin_offOrthosteric Ligandsst2_off
20.69Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
20.69Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
20.69Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
20.69Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
20.69Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
20.69Single9BUCCagrilintide9BUC-CT-Cagrilintide-Gs/β1/γ2
20.69Consensussecretin_on_gpOrthosteric Ligand7D3S-Secretin-Secretin-Gs/β1/γ2
20.51Consensusclass-b1_on_gpOrthosteric Ligandglucagon_on_gp vip-pacap_on_gp pth_on_gp crf_on_gp calcitonin_on_gp
20.00Single2Y00Dobutamine2Y00-β1-Dobutamine
20.00Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
20.00Single5N2RPSB-365N2R-A2A-PSB-36-Na
20.00Single5N2SPSB365N2S-A1-PSB36
20.00Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
20.00Single5T1ABMS-6815T1A-CCR2-BMS-681-PubChem 12093170
20.00Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
20.00Single6HLPNetupitant6HLP-NK1-Netupitant
20.00Single6PS6Timolol6PS6-β2-Timolol
20.00Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
20.00Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
20.00Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
20.00Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
20.00Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
20.00Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
20.00Single7W41PD1762527W41-BB2-PD176252
20.00Single8A2OTheophylline8A2O-A2A-Theophylline-Na
20.00Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
20.00Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
20.00Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
20.00Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
20.00Single8IEBA1LYA8IEB-GPR156-A1LYA
20.00Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
20.00Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
20.00Single8IY6Endothelin-18IY6-ETB-Endothelin-1
20.00Single8QOTNanobody-E8QOT-μ-Nanobody-E
20.00Single8WC5Tetramethylammonium Ion8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
20.00Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
20.00Single8ZMFA1L108ZMF-5-HT2C-A1L10
20.00Single9ARYSerotonin9ARY-5-HT2A-Serotonin-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
20.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single9B9ZA1AKO9B9Z-CB1-A1AKO
20.00Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
20.00Single9DYDAsenapine9DYD-5-HT1A-Asenapine-Go/β1/γ2
20.00Single9DYFAsenapine9DYF-5-HT1A-Asenapine-Gi1/β1/γ2
20.00Single9EE9Adenosine9EE9-A2A-Adenosine-Gs/β1/γ2
20.00Single9IQSMuscarinic toxin 39IQS-M4-Muscarinic toxin 3
20.00Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
20.00Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
20.00Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
20.00Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
20.00Consensusadenosine_offOrthosteric Liganda1_off a2_off
20.00Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
20.00Consensusbombesin_offOrthosteric Ligandbb2_off
20.00Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
20.00Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
20.00Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
20.00Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
20.00Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
20.00Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Consensuspth1_onOrthosteric Ligand6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
19.35Consensuscrf1_onOrthosteric Ligand6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF1-Corticoliberin-Gs/β1/γ2
19.23Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
19.23Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
19.23Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
19.23Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
19.23Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
19.23Consensusclass-b1_class-b2_cons_onOrthosteric Ligandclass-b1_on class-b2_on
19.23Consensusclass-b1_class-b2_cons_on_gpOrthosteric Ligandclass-b1_on_gp class-b2_on_gp
19.23Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
19.23Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
19.23Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
19.23Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
19.05Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
19.05Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
19.05Single4BV0Neurotensin4BV0-NTS1-Neurotensin
19.05Single5TZRMK86665TZR-FFA1-MK8666
19.05Single5V54Methiothepin5V54-5-HT1B-Methiothepin
19.05Single6E59L-7607356E59-NK1-L-760735
19.05Single6J20Aprepitant6J20-NK1-Aprepitant
19.05Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
19.05Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
19.05Single6OS1TRV0266OS1-AT1-TRV026
19.05Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
19.05Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
19.05Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
19.05Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
19.05Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
19.05Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
19.05Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
19.05Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
19.05Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
19.05Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
19.05Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
19.05Single8EA0Iperoxo8EA0-M3-Iperoxo
19.05Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
19.05Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
19.05Single8GDBPGE28GDB-EP4-PGE2-Gs/β1/γ2
19.05Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
19.05Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
19.05Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
19.05Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
19.05Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
19.05Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
19.05Consensus5ht1_offOrthosteric Ligand5ht1b_off
19.05Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
19.05Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
19.05Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
19.05Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
19.05Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
19.05Consensusneurotensin_onOrthosteric Ligandnts1_on
19.05Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
19.05Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
18.75Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
18.75Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
18.75Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
18.75Single6ME5Agomelatine6ME5-MT1-Agomelatine
18.75Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
18.75Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
18.75Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.75Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
18.75Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
18.75Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
18.75Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
18.75Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
18.75Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
18.75Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
18.75Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
18.75Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
18.75Single9AUCCalcitonin gene-related peptide-19AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
18.75Single9JHJC18:0 Ceramide9JHJ-FPR2-ALX-C18:0 Ceramide-Gi1/β1/γ2
18.75Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
18.75Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
18.52Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
18.52Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
18.52Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
18.52Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
18.52Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
18.52Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
18.52Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
18.52Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
18.52Single9EBOGLP-1 (ACPC18)9EBO-GLP-1-GLP-1 (ACPC18)-Gs/β1/γ2
18.18Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
18.18Single4N4WSANT-14N4W-SMO-SANT-1
18.18Single4XEENeurotensin4XEE-NTS1-Neurotensin
18.18Single4XESNeurotensin4XES-NTS1-Neurotensin
18.18Single6OS2TRV0266OS2-AT1-TRV026
18.18Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
18.18Single6YVRNTS8-136YVR-NTS1-NTS8-13
18.18Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
18.18Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
18.18Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.18Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
18.18Single8JD3JNJ-404118138JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
18.18Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
18.18Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
18.18Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
18.18Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.18Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
18.18Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
18.18Single8Y6WTUG-13758Y6W-FFA2-TUG-1375-4-CMTB-Gi1/β1/γ2
18.18Consensuscrf1_on_gpOrthosteric Ligand6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF1-Corticoliberin-Gs/β1/γ2
18.18Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
18.18Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
18.18Consensusglp1_on_gpOrthosteric Ligand7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
18.18Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
18.18Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
18.18Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
18.18Consensuspth1_on_gpOrthosteric Ligand6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
17.86Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
17.86Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
17.86Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.86Consensuscalcitonin_onOrthosteric Ligandctlike_on
17.86Consensusvpac1_onOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
17.65Single3PBLEticlopride3PBL-D3-Eticlopride
17.65Single5L7IVismodegib5L7I-SMO-Vismodegib
17.65Single6HLLCP999946HLL-NK1-CP99994
17.65Single6LI0C176LI0-GPR52-C17
17.65Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
17.65Single6TP4ACT-4622066TP4-OX1-ACT-462206
17.65Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
17.65Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
17.65Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
17.65Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
17.65Single7V68Iperoxo7V68-M4-Iperoxo-LY2119620-Gi1/β1/γ2
17.65Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
17.65Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
17.65Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
17.65Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
17.65Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.65Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
17.65Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
17.65Single8YN2Histamine8YN2-H1-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
17.65Single9AS2DMT9AS2-5-HT2A-DMT-chim(NtGi1-Gs-CtGq)/β1/γ2
17.65Single9AS7Psilocin9AS7-5-HT2A-Psilocin
17.65Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
17.65Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
17.65Consensusgq_nucleotideOrthosteric Ligandgq_p2y
17.65Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
17.65Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
17.39Single4BUONeurotensin4BUO-NTS1-Neurotensin
17.39Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
17.39Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
17.39Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
17.39Single8JPFNeurotensin8JPF-NTS1-Neurotensin-SBI-553
17.39Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
17.39Single8T3OTUG-8918T3O-FFA4-TUG-891-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.39Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
17.39Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
17.39Single9C0KExendin-49C0K-GLP-1-Exendin-4-Gs/β1/γ2
17.24Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
17.24Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
17.24Single9BLWCagrilintide backbone (non-acylated)9BLW-CT (AMY1)-Cagrilintide backbone (non-acylated)-Gs/β1/γ2; RAMP1
17.24Consensuscalcitonin_on_gpOrthosteric Ligandctlike_on_gp
17.24Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
17.24Consensuspac1_onOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
17.24Consensuspac1_on_gpOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
17.24Consensusvpac1_on_gpOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
16.67Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
16.67Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
16.67Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
16.67Single4BWBNeurotensin4BWB-NTS1-Neurotensin
16.67Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
16.67Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
16.67Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
16.67Single6DS0Ly2660976DS0-5-HT2B-Ly266097
16.67Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
16.67Single6ME9Ramelteon6ME9-MT2-Ramelteon
16.67Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
16.67Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
16.67Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
16.67Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
16.67Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
16.67Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
16.67Single7BR3Elagolix7BR3-GnRH1-Elagolix
16.67Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
16.67Single7F8ULintitript7F8U-CCKA-Lintitript
16.67Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
16.67Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
16.67Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
16.67Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
16.67Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
16.67Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
16.67Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
16.67Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
16.67Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
16.67Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
16.67Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
16.67Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
16.67Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
16.67Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
16.67Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
16.67Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
16.67Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
16.67Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single8T3VDocosa-4,7,10,13,16,19-Hexaenoic acid8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
16.67Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
16.67Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
16.67Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
16.67Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
16.67Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
16.67Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
16.67Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single9JF4PD1683689JF4-BB1-PD168368
16.67Single9LRBHistamine9LRB-H1-Histamine-Gs/β1/γ2
16.67Single9NS9TUG-13759NS9-FFA2-TUG-1375-Compound 187-Gi1/β1/γ2
16.67Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
16.67Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
16.67Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
16.67Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
16.67Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
16.67Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
16.13Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
16.13Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
16.13Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
16.13Consensusvpac2_on_gpOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
16.00Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
16.00Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
16.00Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
16.00Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
16.00Single8XWNCXCL88XWN-CXCR2-CXCL8
16.00Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
16.00Single9BUECagrilintide9BUE-CT-Cagrilintide-Gs/β1/γ2
16.00Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
15.79Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
15.79Single3REYXAC3REY-A2A-XAC
15.79Single3RZECidoxepin3RZE-H1-Cidoxepin
15.79Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
15.79Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
15.79Single5IU7Q274563465IU7-A2A-Q27456346-Na
15.79Single5IUBQ274563445IUB-A2A-Q27456344-Na
15.79Single5JTBZM-2413855JTB-A2A-ZM-241385
15.79Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
15.79Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
15.79Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
15.79Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
15.79Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
15.79Single6AQFZM-2413856AQF-A2A-ZM-241385
15.79Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
15.79Single6MH8ZM-2413856MH8-A2A-ZM-241385
15.79Single6TPKRetosiban6TPK-OT-Retosiban
15.79Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
15.79Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
15.79Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
15.79Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
15.79Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
15.79Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
15.79Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
15.79Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
15.79Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
15.79Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
15.79Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
15.79Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
15.79Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
15.79Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
15.79Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
15.79Single9AS3LSD9AS3-5-HT2A-LSD
15.79Single9AS4LSD9AS4-5-HT2A-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
15.79Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
15.79Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
15.79Single9K0KUTP9K0K-P2Y4-UTP-chim(NtGi1-Gs-CtGq)/β1/γ2
15.79Single9K0XATP9K0X-P2Y2-ATP-chim(NtGi1-Gs-CtGq)/β1/γ2
15.79Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Gi1/β1/γ2
15.79Single9K20ATP9K20-P2Y2-ATP-chim(NtGi1-Go)/β1/γ2
15.79Single9LRDHistamine9LRD-H1-Histamine-Gi1/β1/γ2
15.79Consensusa2_offOrthosteric Liganda2a_off
15.79Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
15.79Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
15.79Consensusgrh_offOrthosteric Ligandgnrh1_off
15.79Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
15.79Consensusopsins_offOrthosteric Ligandrhodopsin_off
15.79Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
15.79Consensussensory_offOrthosteric Ligandopsins_off
15.79Consensusvasop-oxy_offOrthosteric Ligandot_off
15.62Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
15.62Consensusgip_onOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
15.62Consensusgip_on_gpOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
15.38Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
15.38Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
15.38Single7SK5CXCL127SK5-ACKR3-CXCL12
15.38Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
15.38Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
15.38Single9IQRMuscarinic toxin 39IQR-α2a-Muscarinic toxin 3
15.15Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
15.15Consensusglp1_onOrthosteric Ligand7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
15.00Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
15.00Single3EMLZM-2413853EML-A2A-ZM-241385
15.00Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
15.00Single4QIMANTA XV4QIM-SMO-ANTA XV
15.00Single5DSGTiotropium5DSG-M4-Tiotropium
15.00Single5IU8Q274563475IU8-A2A-Q27456347-Na
15.00Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
15.00Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
15.00Single5T04Neurotensin5T04-NTS1-Neurotensin
15.00Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
15.00Single6D27CAY104716D27-DP2-CAY10471
15.00Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
15.00Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
15.00Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
15.00Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
15.00Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
15.00Single6S0LZM-2413856S0L-A2A-ZM-241385
15.00Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.00Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
15.00Single6XBM5LWE6XBM-SMO-5LWE-Gi1/β1/γ2
15.00Single7F83PF-051904577F83-Ghrelin-PF-05190457
15.00Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
15.00Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
15.00Single7PYRPSB-21157PYR-A2A-PSB-2115
15.00Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
15.00Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
15.00Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
15.00Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
15.00Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
15.00Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
15.00Single8ZYYNeurotensin peptide 8-138ZYY-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
15.00Single9IVGGLP-1 (Truncated)9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
15.00Single9JGKBalovaptan9JGK-5-HT2B-Balovaptan
15.00Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
15.00Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
14.81Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29Single4JKVTaladegib4JKV-SMO-Taladegib
14.29Single4NTJAZD12834NTJ-P2Y12-AZD1283
14.29Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
14.29Single5CGCHTL142425CGC-mGlu5-HTL14242
14.29Single5IUAQ274563485IUA-A2A-Q27456348-Na
14.29Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
14.29Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
14.29Single6LUQHaloperidol6LUQ-D2-Haloperidol
14.29Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
14.29Single6S0QZM-2413856S0Q-A2A-ZM-241385
14.29Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
14.29Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
14.29Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
14.29Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
14.29Single7SINNPS-21437SIN-CaS-NPS-2143
14.29Single7SINNPS-21437SIN-CaS-NPS-2143
14.29Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
14.29Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
14.29Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
14.29Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
14.29Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
14.29Single8GNEKW-63568GNE-A2A-KW-6356-Na
14.29Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
14.29Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
14.29Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
14.29Single9BLCCagrilintide backbone (non-acylated)9BLC-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
14.29Consensusadgrg2_onOrthosteric Ligand7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
14.29Consensusadgrg2_on_gpOrthosteric Ligand7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
14.29Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
14.29Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
13.89Consensusgluc_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
13.79Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
13.79Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
13.79Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
13.64Single5V56TC1145V56-SMO-TC114
13.64Single5V57TC1145V57-SMO-TC114
13.64Single7F1TMIP-1a7F1T-CCR5-MIP-1a
13.64Single7PX4PSB-21137PX4-A2A-PSB-2113
13.64Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
13.64Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
13.64Single9AS9RS130-1809AS9-5-HT2A-RS130-180
13.64Single9ASARS130-1809ASA-5-HT2A-RS130-180-chim(NtGi1-Gs-CtGq)/β1/γ2
13.64Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
13.64Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
13.64Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
13.64Consensustachykinin_offOrthosteric Ligandnk1_off
13.51Consensusgluc_on_gpOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
13.33Single3PXOAll-trans-Retinal3PXO-Rhodopsin-All-trans-Retinal
13.33Single5DYSAll-trans-Retinal5DYS-Rhodopsin-All-trans-Retinal
13.33Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
13.33Single7V68LY21196207V68-M4-Iperoxo-LY2119620-Gi1/β1/γ2
13.33Single7WC4Serotonin7WC4-5-HT2A-Serotonin
13.33Single7XKDBeta-Hydroxyandrosterone7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
13.33Single8PWNTheophylline8PWN-A2A-Theophylline
13.33Single9BP3Cagrilintide9BP3-CT (AMY1)-Cagrilintide-Gs/β1/γ2; RAMP1
13.33Consensuscrf2_on_gpOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
13.04Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
13.04Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
13.04Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
13.04Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
13.04Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
13.04Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
13.04Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.04Single9CM3TUG-13759CM3-FFA2-TUG-1375-Compound 187-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.04Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
13.04Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
12.90Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
12.90Consensusglp2_on_gpOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
12.50Single2HPYAll-trans-Retinal2HPY-Rhodopsin-All-trans-Retinal
12.50Single3RFMCaffeine3RFM-A2A-Caffeine
12.50Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
12.50Single5CGDHTL142425CGD-mGlu5-HTL14242
12.50Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
12.50Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
12.50Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
12.50Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
12.50Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
12.50Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
12.50Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
12.50Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
12.50Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
12.50Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-SBI-553-chim(NtGi1-Go)/β1/γ2
12.50Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single8XVUCXCL28XVU-CXCR2-CXCL2
12.50Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
12.50Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
12.50Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
12.50Consensusp2y_offOrthosteric Ligandp2y1_off
12.50Consensussensory_onOrthosteric Ligandopsins_on
12.00Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
12.00Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
12.00Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
12.00Single9CM7TUG-13759CM7-FFA2-TUG-1375-AZ-1729-Gi1/β1/γ2
11.76Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
11.76Single3PQRAll-trans-Retinal3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
11.76Single4XNWMRS25004XNW-P2Y1-MRS2500
11.76Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
11.76Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
11.76Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
11.76Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
11.76Single7WC5Psilocin7WC5-5-HT2A-Psilocin
11.76Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
11.76Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
11.76Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
11.76Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
11.76Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
11.76Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
11.76Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
11.54Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
11.54Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
11.54Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.54Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
11.54Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
11.54Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
11.11Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
11.11Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
11.11Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
11.11Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
11.11Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
11.11Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
11.11Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
11.11Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
11.11Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
11.11Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
11.11Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
11.11Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
11.11Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
11.11Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
11.11Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab
11.11Single8ZYUNeurotensin peptide 8-138ZYU-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
11.11Single9EPRRetinal9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
11.11Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg4_on
11.11Consensusadgrg_on_gpOrthosteric Ligandadgrg2_on_gp adgrg4_on_gp
10.53Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
10.53Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
10.53Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
10.53Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
10.53Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
10.53Single7VVOPTH7VVO-PTH1-PTH-Gs/β1/γ2
10.53Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
10.53Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
10.53Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
10.53Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
10.53Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
10.53Single8YYWAlpha-ketoglutarate8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
10.53Single9H2XA1IR19H2X-A2A-A1IR1-Na
10.53Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
10.53Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
10.53Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
10.34Single9BUDCagrilintide9BUD-CT-Cagrilintide-Gs/β1/γ2
10.34Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
10.00Single5UVIZM-2413855UVI-A2A-ZM-241385
10.00Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
10.00Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
10.00Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
10.00Single6ZINSR486926ZIN-NTS1-SR48692
10.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
10.00Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
10.00Single7VODCariprazine7VOD-5-HT2A-Cariprazine
10.00Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
10.00Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Single9IXXLTD49IXX-CysLT2-LTD4-chim(NtGi1-Gs-CtGq)/β1/γ2
9.68Single9BLBCagrilintide backbone (non-acylated)9BLB-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
9.52Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
9.52Single8TH3AT118-H Nanobody8TH3-AT1-AT118-H Nanobody
9.52Single9IMATalquetamab9IMA-GPRC5D-Talquetamab
9.38Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
9.09Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
9.09Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
9.09Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
9.09Single6Z4SSR486926Z4S-NTS1-SR48692
9.09Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
9.09Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
9.09Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
9.09Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
9.09Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
9.09Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
9.09Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
9.09Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
9.09Single8ZYTNeurotensin peptide 8-138ZYT-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
9.09Single9BQ3Cagrilintide9BQ3-CT (AMY2)-Cagrilintide-Gs/β1/γ2; RAMP2
9.09Single9BTWCagrilintide9BTW-CT (AMY3)-Cagrilintide-Gs/β1/γ2; RAMP3
9.09Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single9HC04YI9HC0-mGlu5-4YI
8.70Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
8.70Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
8.70Single7P2L4YI7P2L-mGlu5-4YI
8.70Single7R0CAVP7R0C-V2-AVP-Arrestin2
8.70Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
8.70Single7T9NDPPC7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
8.70Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
8.70Single8JD5JNJ-40411813; ADX881788JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
8.70Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
8.70Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
8.70Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
8.70Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Gi1/β1/γ1
8.70Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
8.70Single9CLWTUG-13759CLW-FFA2-TUG-1375-4-CMTB-chim(NtGi1L-Gs-CtGq)/β1/γ2
8.33Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
8.33Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
8.33Single8XQJJN2418XQJ-Apelin-JN241
8.33Single8XWACXCL18XWA-CXCR2-CXCL1
8.33Single8XWMCXCL68XWM-CXCR2-CXCL6
8.33Single8XWSCXCL58XWS-CXCR2-CXCL5
8.33Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
8.00Single8XWFCXCL38XWF-CXCR2-CXCL3
8.00Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
7.69Single6KNMJN241-96KNM-Apelin-JN241-9
7.69Single8XQJJN2418XQJ-Apelin-JN241
7.69Consensusclass-b2_onOrthosteric Ligandadgrg_on adgrf_on adgrl_on adgre_on adgrd_on
7.69Consensusclass-b2_on_gpOrthosteric Ligandadgrg_on_gp adgrf_on_gp adgrl_on_gp adgre_on_gp adgrd_on_gp
7.14Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
6.67Single4A4MAll-trans-Retinal4A4M-Rhodopsin-All-trans-Retinal-Gt(CT)
6.67Single5EN0All-trans-Retinal5EN0-Rhodopsin-All-trans-Retinal-Gt(CT)
6.67Single5MZPCaffeine5MZP-A2A-Caffeine-Na
6.25Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
6.25Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
6.25Single9BUBCagrilintide9BUB-CT-Cagrilintide-Gs/β1/γ2
6.25Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
5.88Single6OY9All-trans-Retinal6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
5.88Single6XBM5LWE6XBM-SMO-5LWE-Gi1/β1/γ2
5.88Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
5.88Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Gi1/β1/γ2
5.88Single8Y02Retinal8Y02-OPN1SW-Retinal-Gi1/β1/γ2
5.88Single9IVMLSN33188399IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
5.88Consensusctlike_on_gpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
5.56Single3UZAGTPL92363UZA-A2A-GTPL9236
5.56Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
5.56Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
5.56Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/β1/γ2
5.56Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
5.56Single8J6QCompound 9n8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
5.56Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
5.56Consensusgi_sensoryOrthosteric Ligandgi_opsins
5.56Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
5.56Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
5.26Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
5.26Single4O9RCyclopamine4O9R-SMO-Cyclopamine
5.26Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.26Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
5.26Single7UL2SR486927UL2-NTS1-SR48692-Na
5.26Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
5.26Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
5.26Single8HSCFab0468HSC-GPR20-Fab046-Gi1/β1/γ2
5.26Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
5.26Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/β1/γ2
5.26Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
5.26Single8YKDDehydroepiandrosterone8YKD-ADGRG2-Dehydroepiandrosterone-chim(NtGi1-Gs)/β1/γ2
5.26Single9E7RGB889E7R-PAR2-GB88-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.26Consensusneurotensin_offOrthosteric Ligandnts1_off
5.26Consensusnts1_offOrthosteric Ligand7UL2-NTS1-SR48692-Na
5.00Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
5.00Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
5.00Single4QINSAG1.54QIN-SMO-SAG1.5
5.00Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
5.00Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
5.00Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
5.00Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
5.00Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
4.76Single6FFIMMPEP6FFI-mGlu5-MMPEP
4.76Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
4.76Single7UTZDPPC7UTZ-TSH-TR1402-DPPC-Gs/β1/γ2
4.76Single7VV6C48/807VV6-MRGPRX2-C48/80
4.76Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
4.76Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Single8IYXYL-3658IYX-GPR34-YL-365
4.55Single6FFHFenobam6FFH-mGlu5-Fenobam
4.55Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
4.35Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
4.35Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
4.35Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
4.17Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
3.85Single9JH5C16:0 Ceramide9JH5-CysLT2-C16:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2

Consensus Members
Id Members
8GUR 8GUR-CB2-CP55,940-Gi1/β1/γ2
8GUS 8GUS-CB2-HU-308-Gi1/β1/γ2
8GUT 8GUT-CB2-LEI-102-Gi1/β1/γ2
6KPF 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2
6PT0 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2
8GUQ 8GUQ-CB2-Olorinab-Gi1/β1/γ2
Net Summary
Imin 3.2
Number of Linked Nodes 1021
Number of Links 1209
Number of Hubs 181
Number of Links mediated by Hubs 680
Number of Communities 22
Number of Nodes involved in Communities 234
Number of Links involved in Communities 341
Path Summary
Number Of Nodes in MetaPath 114
Number Of Links MetaPath 113
Number of Shortest Paths 2252830
Length Of Smallest Path 3
Average Path Length 42.0407
Length of Longest Path 81
Minimum Path Strength 0.29
Average Path Strength 5.98691
Maximum Path Strength 22.4358
Minimum Path Correlation 0.701667
Average Path Correlation 0.980448
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.42857
Average % Of Corr. Nodes 31.744
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 54.7316
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following differences:
Id1st Network2nd Network
cb2_off_on_gpcb2_on_gpcb2_off
This network is also present in following consensuses:
IdComponents
cannabinoid_on_gpcb2_on_gp
cb1_on_gp



You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download cb2_on_gp.zip



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