Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
1b.1x1 1.8775404
2b.lh12x2 4.38408
3b.h2x1 3.105625
4b.lhb1x6 4.44423
5b.b1x6 9.5775489
6b.l1x3 7.79789
7b.b2x5 6.46507
8b.b3x3 4.2075498
9b.l3x1 8.5025409
10b.l3x2 7.3475489
11b.b4x3 4.555407
12b.b4x5 5.148597
13b.b4x6 10.3983689
14b.b5x2 6.3407
15b.b5x3 7.4689
16b.b5x5 6.022595
17b.l5x1 4.475408
18b.l5x5 7.947139
19b.b6x1 5.53539
20b.b6x5 5.06714796
21b.b8x3 4.8325436
22b.b8x4 6.668596
23b.l8x1 4.716595
24b.l8x8 5.73494
25b.l9x3 6.37639
26b.l9x6 12.512538
27b.b10x2 3.195406
28b.b10x5 4.76429739
29b.l10x1 3.6375403
30b.b11x2 5.03437
31b.b11x4 4.655639
32b.l11x2 6.326539
33b.b12x2 4.0625437
34b.b12x3 4.766578
35b.b12x6 7.54833638
36b.l12x1 5.25436
37b.b13x7 8.244577
38b.l13x3 8.438579
39b.l13x6 7.85439
40b.l13x7 4.685479
41b.b14x3 5.005475
42b.b15x1 8.55579
43b.b15x3 4.6075479
44b.l15x2 6.0175409
45b.b16x6 8.93578
46b.b16x7 7.63754169
47b.b17x5 7.65547
48b.b17x7 7.8175448
49b.l17x3 8.42649
50b.l17x7 6.5975447
51b.b18x3 5.986548
52b.b18x5 4.615645
53b.l18x1 6.79429766
54b.b19x2 7.07125846
55b.b19x4 6.744548
56b.l19x2 6.876549
57b.b20x2 4.07446
58b.b20x4 8.476548
59b.l20x1 4.2075446
60b.b21x1 10.7675447
61b.b21x7 7.584565
62b.l21x5 5.405464
63b.b22x4 3.2325425
64b.b22x5 5.14667667
65b.l22x5 5.636529
66b.b23x2 5.48466
67b.b23x3 3.90333627
68b.b23x6 7.774567
69b.l23x1 5.98406
70b.b24x3 3.42425
71b.b24x5 3.74525
72b.b24x6 10.5975468
73b.l24x2 4.13426
74b.b25x7 5.886527
75b.l25x3 10.456529
76b.l25x6 9.2365128
77b.b26x3 4.5526
78b.l26x1 5.81254157
79b.b27x1 3.9575426
80b.b27x3 5.43428
81b.l27x1 16.24254129
82b.l27x2 6.87429
83b.b28x3 5.08667687
84b.b28x4 9.135426
85b.b28x6 7.55629
86b.b28x7 5.4975429
87g.h1x1 1.9975402
88g.h1x8 3.7275407
89g.h1x11 4.49409
90g.l1x4 6.914548
91g.ctx3 8.076529
92g.ctx5 5.4375429
93g.ctx6 3.915626
94g.ctx15 7.8825429
95g.ctx16 5.08111928
961x39 4.5975418
971x46 6.295419
982x40 5.27409
992x42 6.373336198
1002x46 6.14149
1012x50 7.5565149
1022x57 5.13333619
1032x59 6.354518
1042x60 8.35418
1052x64 2.6418
106E1x50 7.94375819
107E1x52 6.6375419
1083x28 9.5519
1093x29 4.178519
1103x32 10.395419
1113x33 9.618519
1123x37 7.036519
1133x45 3.93754198
1143x51 9.45754209
115I2x56 10.20754218
1164x50 4.794519
1174x53 2.9875419
1184x57 7.824518
119E2.F168 6.4225406
120E2.Q171 9.06754112
121E2.V174 7.344112
122E2x50 6.315419
123E2x51 5.564117
124E2.F184 5.7225419
1255x39 4.192509
1265x461 7.82419
1275x47 11.398519
1285x48 6.685418
1295x54 5.87409
1305x57 7.8425407
1315x58 5.9475409
1326x29 8.885408
1336x44 6.1375419
1346x48 6.8719
1356x51 7.69333619
1366x52 9.59333619
1377x38 5.73833618
1387x39 4.99719
1397x42 6.97375819
1407x53 5.5545149
1418x48 5.084185
1428x50 5.0554189
1438x54 4.465409
144Lig 10.11910
145G.S1.04 4.808556
146G.S1.06 5.034558
147G.H1.01 4.876559
148G.H1.04 7.208557
149G.S2.03 8.60754139
150G.S2.06 5.2775458
151G.S3.03 5.4075457
152G.S3.05 6.3175457
153G.H2.06 8.6125439
154G.H2.07 9.78286739
155G.h2s4.01 6.684139
156G.S4.02 4.5975407
157G.S4.03 4.338557
158G.S4.05 4.7875457
159G.s4h3.03 9.8325407
160G.s4h3.04 7.114108
161G.H3.09 10.13409
162G.H3.17 4.655405
163G.S5.05 5.0675459
164G.S5.06 4.8585268
165G.HG.15 6.94254106
166G.hgh4.01 6.7165105
167G.hgh4.02 7.3945108
168G.hgh4.05 7.2025406
169G.H4.12 4.83754265
170G.S6.01 3.1154256
171G.S6.02 5.7885278
172G.s6h5.01 5.75659
173G.s6h5.05 7.104559
174G.H5.20 5.03408
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1b.1x11 g.h1x12 10.5992.82NoNo086
2b.1x11 g.h1x11 11.27315.54NoYes089
3g.h1x11 g.h1x14 12.2822.65YesNo099
4b.b19x2 b.b19x4 10.7173.89YesYes468
5b.b19x4 b.l17x3 18.23136.85YesYes489
6b.b19x6 b.l17x3 11.079316.74NoYes499
7b.b19x6 b.l17x5 11.25123.26NoNo496
8b.l17x5 b.l19x1 24.20332.94NoNo069
9b.l19x1 b.l21x8 34.00795.03NoNo094
10b.l21x8 b.l23x1 33.88583.35NoYes046
11b.l21x7 b.l23x1 19.59529.34NoYes056
12b.l21x7 b.l23x2 19.36273.11NoNo058
13b.b23x6 b.l23x2 18.43373.45YesNo078
14b.b23x6 b.b24x6 11.46375.79YesYes678
15b.b21x7 b.b24x6 11.225618.33YesYes658
16b.l17x3 b.l19x2 11.14773.78YesYes499
17b.l17x5 b.l19x2 12.79718.83NoYes469
18b.b22x1 b.l23x1 19.51592.89NoYes086
19b.b22x1 b.b22x2 19.32363.2NoNo088
20b.b22x2 b.b26x3 19.14297.51NoYes086
21b.b23x3 b.b26x3 14.42614.15YesYes276
22b.b10x2 b.b14x3 15.05493.17YesYes065
23b.b10x1 b.b10x2 18.49463.44NoYes096
24G.H2.07 b.b10x1 17.15134.94YesNo399
25b.l5x5 b.l7x2 40.117411.39YesNo099
26G.S1.03 b.l5x5 44.90465.8NoYes099
27G.S1.03 b.l3x1 44.79368.14NoYes099
28b.l1x5 b.l3x1 38.32047.58NoYes079
29b.l1x5 b.l3x2 38.06193.09NoYes079
30b.l1x3 b.l3x2 36.53213.78YesYes899
31b.b4x6 b.l1x3 25.04413.17YesYes899
32b.b1x6 b.b4x6 18.876922.78YesYes899
33b.b1x6 b.b28x5 18.01614.28YesNo095
34b.b28x5 g.ctx16 15.87353.77NoYes058
35G.H2.07 b.l9x6 42.40322.19YesYes398
36b.l7x2 b.l9x6 36.44459.38NoYes098
37b.l4x2 g.ctx16 15.99427.22NoYes248
38b.l2x5 b.l4x2 16.440826.75NoNo054
39b.l2x3 b.l2x5 11.27133.57NoNo085
40b.b3x1 b.l2x3 10.89985.43NoNo058
41b.b3x1 b.b6x5 10.52815.86NoYes056
42G.S2.03 b.l5x5 30.908610.9YesYes1399
43G.S2.01 G.S2.03 31.04474.1NoYes099
44G.S2.01 G.S3.08 31.13946.14NoNo099
45G.S3.08 b.l9x6 69.39983.79NoYes098
46G.h2s4.01 b.l5x5 43.76879.02YesYes1399
47G.H2.07 b.l11x1 16.7185.63YesNo399
48b.b11x6 b.l11x1 16.56173.71NoNo399
49b.b11x6 b.l9x3 14.527516.74NoYes399
50b.b11x4 b.l9x3 11.34265.48YesYes399
51b.b11x2 b.b11x4 10.65263.04YesYes379
52G.H2.06 b.b14x1 25.483212.96YesNo398
53G.H2.06 b.b18x1 33.60314.2YesNo099
542x57 7x42 15.92863.59YesYes199
552x53 7x42 20.33683.79NoYes199
562x53 7x46 21.1518.08NoNo099
572x50 7x46 21.542810.31YesNo099
582x46 2x50 23.89665.43YesYes1499
592x46 7x53 28.48023.52YesYes1499
603x46 7x53 32.37438.21NoYes099
612x42 3x46 16.73935.86YesNo089
622x42 3x49 49.49113.79YesNo089
633x49 3x53 49.63524.42NoNo099
643x53 G.H5.19 85.06242.98NoNo098
65G.H5.15 G.H5.19 85.19824.25NoNo088
66G.H5.11 G.H5.15 85.34593.07NoNo088
67G.H5.11 G.S1.04 84.95642.98NoYes586
68G.S1.04 G.S4.03 89.41782.83YesYes567
69G.S1.06 G.S4.03 90.11134.24YesYes587
70G.H1.01 G.S1.06 90.00395.64YesYes598
71G.H1.01 G.s3h2.01 99.80111.74YesNo099
72G.S3.08 G.s3h2.01 1003.68NoNo099
737x42 Lig 11.07434.41YesYes190
743x37 Lig 17.42865.55YesYes190
753x37 4x53 28.17583.2YesYes199
764x50 4x53 29.95473.71YesYes199
772x45 4x50 31.58084.94NoYes099
782x45 4x46 31.64379.29NoNo099
792x42 4x46 31.83214.84YesNo089
803x46 3x50 16.38936.07NoNo099
813x50 G.H5.23 35.18655.14NoNo094
823x53 G.H5.23 35.32873.82NoNo094
832x60 3x28 12.143411.3YesYes189
843x37 4x57 10.69899.7YesYes198
855x54 6x44 11.71998.71YesYes099
863x47 5x54 12.49466.48NoYes089
873x47 5x58 14.044914.79NoYes089
883x50 5x58 19.07343.09NoYes099
89G.S1.05 G.h2s4.01 21.91338.53NoYes099
90G.S1.05 G.S1.07 21.63429.69NoNo099
91G.H3.18 G.S4.02 10.68176.28NoYes097
92G.H2.08 G.H3.18 10.88977.54NoNo089
93G.H2.08 G.H3.17 11.57017.05NoYes085
94G.H3.02 G.s4h3.03 20.43538.12NoYes087
95G.H3.02 G.H4.11 21.50794.37NoNo088
96G.H4.11 G.s4h3.01 22.58024.28NoNo087
97G.S5.06 G.s4h3.01 24.7248.3YesNo087
98G.S5.04 G.S5.06 12.83664.15NoYes088
99G.H3.09 G.S5.04 13.37153.65YesNo098
100G.H3.09 G.S6.01 32.06483.65YesYes096
101G.S5.02 G.S6.01 48.52942.98NoYes2566
102G.S4.02 G.S5.02 52.2483.07YesNo076
103G.H4.12 G.S5.06 12.8452.77YesYes2658
104G.H4.12 G.H4.16 15.50032.98YesNo053
105G.H4.16 G.S6.01 16.03522.98NoYes036
106G.S4.07 G.s4h3.03 12.91884.53NoYes087
107G.h2s4.01 G.h2s4.04 21.62293.93YesNo099
108G.h2s4.04 G.h3s5.03 21.3423.23NoNo097
109G.H3.09 G.H4.15 17.651511.79YesNo099
110G.H3.06 G.H4.14 14.58138.64NoNo075
111G.H3.06 G.H4.15 16.72333.72NoNo079
112b.b18x1 b.l19x1 33.52554.04NoNo099
113G.H2.07 b.b14x1 24.04658.14YesNo398
114G.S1.07 G.S4.02 21.20482.85NoYes097
115G.S4.02 G.h3s5.03 21.11796.19YesNo077
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
2x532x563.211NoNo9922
2x537x423.791NoYes9921
2x563x3213.151NoYes9921
2x567x425.051NoYes9921
2x577x394.651YesYes9922
2x577x423.591YesYes9921
2x607x387.081YesYes8821
2x607x393.391YesYes8922
2x607x4211.631YesYes8921
3x323x364.421YesNo9911
3x327x4213.791YesYes9911
3x32Lig10.221YesYes9010
3x334x5715.431YesYes9812
3x334x613.631YesNo9912
3x33E2.F1846.191YesYes9912
3x336x512.981YesYes9911
3x33Lig19.861YesYes9010
3x366x484.941NoYes9912
3x36Lig7.071NoYes9010
3x373x416.491YesNo9812
3x374x533.21YesYes9912
3x374x579.71YesYes9812
3x375x46110.241YesYes9911
3x37Lig5.551YesYes9010
3x415x4617.251NoYes8921
4x57E2.F1844.011YesYes8922
5x4616x526.041YesYes9911
5x461Lig7.751YesYes9010
5x476x483.011YesYes9922
5x476x5223.581YesYes9921
6x486x512.891YesYes9921
6x486x524.011YesYes9921
6x516x526.191YesYes9911
6x517x374.991YesNo9912
6x517x384.841YesYes9811
6x51Lig24.271YesYes9010
6x526x558.571YesNo9812
6x52Lig9.171YesYes9010
7x347x386.630NoYes7821
7x387x393.521YesYes8912
7x387x429.671YesYes8911
7x38Lig2.691YesYes8010
7x397x423.861YesYes9921
7x42Lig4.411YesYes9010

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
90.00Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
88.89Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
88.89Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
81.82Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
81.82Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
81.82Single9JEAAtropine9JEA-M1-Atropine
81.82Single9PQD(6m)-1-methyl-6-(1,2,5,6-tetrahydropyridin-3-yl)-1h-indole9PQD-α2a-(6m)-1-methyl-6-(1,2,5,6-tetrahydropyridin-3-yl)-1h-indole
81.82Consensusalpha2_onOrthosteric Ligandalpha2b_on
81.82Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
81.82Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
81.82Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
81.82Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
80.00Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
80.00Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
77.78Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
75.00Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
75.00Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
75.00Single9ARZ2-bromo-LSD9ARZ-5-HT2A-2-bromo-LSD
75.00Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
75.00Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
75.00Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
72.73Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
72.73Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
72.73Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
72.73Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
72.73Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
72.73Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
72.73Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
72.73Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
72.73Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
72.73Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
72.73Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
72.73Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
72.73Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
72.73Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
72.73Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
72.73Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
72.73Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
72.73Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
72.73Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
72.73Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
72.73Single9AS5Mescaline9AS5-5-HT2A-Mescaline
72.73Single9AS6Mescaline9AS6-5-HT2A-Mescaline-chim(NtGi1-Gs-CtGq)/β1/γ2
72.73Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
72.73Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
72.73Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
70.00Single7SRQLSD7SRQ-5-HT2B-LSD
70.00Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
70.00Single8YN2Histamine8YN2-H1-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
70.00Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
70.00Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
70.00Single8YN7Immethridine8YN7-H3-Immethridine-Go/β1/γ2
70.00Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
69.23Single4U15Tiotropium4U15-M3-Tiotropium
69.23Single6OL9Tiotropium6OL9-M5-Tiotropium
69.23Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
69.23Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
69.23Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
69.23Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
69.23Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
69.23Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
69.23Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
69.23Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
69.23Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
66.67Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
66.67Single4MQSIperoxo4MQS-M2-Iperoxo
66.67Single4U14Tiotropium4U14-M3-Tiotropium
66.67Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
66.67Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
66.67Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
66.67Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
66.67Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
66.67Single6H7MSalbutamol6H7M-β1-Salbutamol
66.67Single6PS1Timolol6PS1-β2-Timolol
66.67Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
66.67Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
66.67Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
66.67Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
66.67Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
66.67Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
66.67Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
66.67Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
66.67Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
66.67Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
66.67Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
66.67Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
66.67Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
66.67Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
66.67Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
66.67Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
66.67Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
66.67Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
66.67Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
66.67Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
66.67Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
66.67Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
66.67Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
66.67Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
66.67Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
66.67Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
66.67Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
66.67Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
66.67Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
66.67Single8JJOAlprenolol8JJO-β2-Alprenolol
66.67Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
66.67Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
66.67Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
66.67Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
66.67Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
66.67Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
66.67Single8YN8Proxyfan8YN8-H3-Proxyfan-Go/β1/γ2
66.67Single9AS1DMT9AS1-5-HT2A-DMT
66.67Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
66.67Single9CHUNoradrenaline9CHU-β2-Noradrenaline
66.67Single9PLNN-(5-methylnaphthalen-1-yl)pyridin-4-amine9PLN-α2a-N-(5-methylnaphthalen-1-yl)pyridin-4-amine
66.67Single9PLON-(5-methylnaphthalen-1-yl)pyridin-4-amine9PLO-α2a-N-(5-methylnaphthalen-1-yl)pyridin-4-amine-Go/β1/γ2
66.67Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
66.67Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
66.67Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
66.67Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
66.67Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
66.67Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
66.67Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
66.67Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
66.67Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
64.29Single3D4STimolol3D4S-β2-Timolol
64.29Single5CXVTiotropium5CXV-M1-Tiotropium
64.29Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
64.29Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
64.29Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
64.29Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
64.29Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
64.29Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
64.29Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
64.29Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
64.29Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
64.29Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
63.64Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
63.64Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
63.64Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
63.64Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
63.64Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
63.64Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
63.64Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
63.64Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
63.64Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
63.64Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
63.64Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
63.64Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
63.64Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
63.64Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
63.64Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
63.64Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
63.64Consensusalpha2_offOrthosteric Ligandalpha2c_off
63.64Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
63.64Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
61.54Single2RH1S-Carazolol2RH1-β2-S-Carazolol
61.54Single2Y03Isoprenaline2Y03-β1-Isoprenaline
61.54Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
61.54Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
61.54Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
61.54Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
61.54Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
61.54Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
61.54Single7WC6LSD7WC6-5-HT2A-LSD
61.54Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
61.54Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
61.54Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
61.54Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
61.54Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
61.54Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
61.54Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
61.54Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
61.54Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
61.54Single9DYDAsenapine9DYD-5-HT1A-Asenapine-Go/β1/γ2
61.54Single9DYFAsenapine9DYF-5-HT1A-Asenapine-Gi1/β1/γ2
61.54Single9F33FOB02-04A9F33-D3-FOB02-04A-Go/β1/γ2
61.54Single9F34FOB02-04A9F34-D3-FOB02-04A-Go/β1/γ2
61.54Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
61.54Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
61.54Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
61.54Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
61.54Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
61.54Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
61.54Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
61.54Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
61.54Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
61.54Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
61.54Consensusamine_offonOrthosteric Ligandamine_off amine_on
61.54Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
61.54Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
61.54Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
61.54Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
61.54Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
61.54Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
61.54Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
61.54Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
61.54Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
61.54Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
61.54Consensustrace-amine_onOrthosteric Ligandta1_on
60.00Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
60.00Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
60.00Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
60.00Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
60.00Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
60.00Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
60.00Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
60.00Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
60.00Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
60.00Single8S2TIsoprenaline8S2T-β1-Isoprenaline-chim(NtGi1-Gs)/β1/γ2
60.00Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
60.00Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
60.00Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
60.00Single9AS02-bromo-LSD9AS0-5-HT2A-2-bromo-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
60.00Single9DYEBuspirone9DYE-5-HT1A-Buspirone-Go/β1/γ2
60.00Single9LRCHistamine9LRC-H4-Histamine
60.00Single9LREHistamine9LRE-H4-Histamine-Gi1/β1/γ2
60.00Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
60.00Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
58.33Single3RZECidoxepin3RZE-H1-Cidoxepin
58.33Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
58.33Single6PS0S-Carazolol6PS0-β2-S-Carazolol
58.33Single6PS4ICI118-5516PS4-β2-ICI118-551
58.33Single6PS5S-Propranolol6PS5-β2-S-Propranolol
58.33Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
58.33Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
58.33Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
58.33Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
58.33Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
58.33Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
58.33Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
58.33Single7T94Acetylcholine7T94-M2-Acetylcholine-LY2119620-chim(NtGi1-Go)/β1/γ2
58.33Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
58.33Single7UL3Famotidine7UL3-H2-Famotidine
58.33Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
58.33Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
58.33Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
58.33Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
58.33Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
58.33Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
58.33Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
58.33Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
58.33Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
58.33Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
58.33Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
58.33Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
58.33Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
58.33Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
58.33Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
58.33Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
58.33Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
58.33Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
58.33Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
58.33Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
58.33Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
58.33Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
58.33Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
58.33Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
58.33Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
58.33Single9AS3LSD9AS3-5-HT2A-LSD
58.33Single9AS4LSD9AS4-5-HT2A-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
58.33Single9LRDHistamine9LRD-H1-Histamine-Gi1/β1/γ2
58.33Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
58.33Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
58.33Consensusalpha1_onOrthosteric Ligandalpha1a_on
58.33Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
58.33Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
58.33Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
57.14Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
57.14Single5D5AS-Carazolol5D5A-β2-S-Carazolol
57.14Single5D5BS-Carazolol5D5B-β2-S-Carazolol
57.14Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
57.14Single6H7JIsoprenaline6H7J-β1-Isoprenaline
57.14Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
57.14Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
57.14Single6TQ7SB-3348676TQ7-OX1-SB-334867
57.14Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
57.14Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
57.14Single8EA0Iperoxo8EA0-M3-Iperoxo
57.14Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
57.14Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
57.14Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
57.14Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
57.14Single9AS9RS130-1809AS9-5-HT2A-RS130-180
57.14Single9ASARS130-1809ASA-5-HT2A-RS130-180-chim(NtGi1-Gs-CtGq)/β1/γ2
57.14Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
57.14Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
57.14Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
57.14Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
57.14Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
57.14Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
57.14Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
57.14Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
57.14Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
57.14Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
57.14Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
57.14Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
57.14Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
56.25Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
56.25Single9MD1Buspirone9MD1-5-HT1A-Buspirone-Gz/β1/γ2
54.55Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
54.55Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
54.55Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
54.55Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
54.55Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
54.55Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
54.55Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
54.55Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
54.55Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
54.55Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
54.55Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
54.55Single9AS2DMT9AS2-5-HT2A-DMT-chim(NtGi1-Gs-CtGq)/β1/γ2
54.55Single9AS7Psilocin9AS7-5-HT2A-Psilocin
54.55Single9IXJHistamine9IXJ-H2-Histamine-Gs/β1/γ2
53.85Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
53.85Single2Y04Salbutamol2Y04-β1-Salbutamol
53.85Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
53.85Single3NY8ICI118-5513NY8-β2-ICI118-551
53.85Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
53.85Single4DAJTiotropium4DAJ-M3-Tiotropium
53.85Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
53.85Single4GBRS-Carazolol4GBR-β2-S-Carazolol
53.85Single4QKX35V4QKX-β2-35V
53.85Single5DSGTiotropium5DSG-M4-Tiotropium
53.85Single6DRXLisuride6DRX-5-HT2B-Lisuride
53.85Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
53.85Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
53.85Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
53.85Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
53.85Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
53.85Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
53.85Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
53.85Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
53.85Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
53.85Single7WC7Lisuride7WC7-5-HT2A-Lisuride
53.85Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
53.85Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
53.85Single8JXRLSD8JXR-D1-LSD
53.85Single8PJKST1718PJK-5-HT1A-ST171-Gi1/β1/γ1
53.85Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
53.85Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
53.85Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
53.85Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
53.85Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
53.85Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
53.85Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
53.85Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
53.85Single8X63Mepyramine8X63-H1-Mepyramine
53.85Single8X64Desloratadine8X64-H1-Desloratadine
53.85Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
53.85Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
53.85Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
53.85Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
53.85Consensus5ht5_onOrthosteric Ligand5ht5a_on
53.85Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
53.85Consensusdopamine_offOrthosteric Ligandd2_off d3_off
53.85Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
53.85Consensushistamine_offOrthosteric Ligandh1_off
53.85Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
53.33Single4AMIBucindolol4AMI-β1-Bucindolol
53.33Single4LDEBI1671074LDE-β2-BI167107
53.33Single6CM4Risperidone6CM4-D2-Risperidone
53.33Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
53.33Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
53.33Single6ZG4HTL00099366ZG4-M1-HTL0009936
53.33Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
53.33Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
53.33Single8JJ8Formoterol8JJ8-β2-Formoterol
53.33Single9GL2Befiradol9GL2-5-HT1A-Befiradol-Gs/β1/γ2
53.33Consensusalpha1_offOrthosteric Ligandalpha1a_off
53.33Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
53.33Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
53.33Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
53.33Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
53.33Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
53.33Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
53.33Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
52.94Single4IARErgotamine4IAR-5-HT1B-Ergotamine
52.94Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
52.94Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
50.00Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
50.00Single2YCWS-Carazolol2YCW-β1-S-Carazolol
50.00Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
50.00Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
50.00Single5C1MBU725C1M-μ-BU72
50.00Single5D6LS-Carazolol5D6L-β2-S-Carazolol
50.00Single5JQHS-Carazolol5JQH-β2-S-Carazolol
50.00Single5WIUNemonapride5WIU-D4-Nemonapride
50.00Single5WIVNemonapride5WIV-D4-Nemonapride-Na
50.00Single5X7DS-Carazolol5X7D-β2-S-Carazolol-Cmpd-15
50.00Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
50.00Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
50.00Single6E67BI1671076E67-β2-BI167107-Gs(CT)
50.00Single6H7LDobutamine6H7L-β1-Dobutamine
50.00Single6IBLArformoterol6IBL-β1-Arformoterol
50.00Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
50.00Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
50.00Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
50.00Single6PS6Timolol6PS6-β2-Timolol
50.00Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
50.00Single7C61Ergotamine7C61-5-HT1B-Ergotamine
50.00Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
50.00Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
50.00Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
50.00Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
50.00Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
50.00Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
50.00Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
50.00Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
50.00Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
50.00Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
50.00Single7UM4AS26747237UM4-5-HT5A-AS2674723
50.00Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
50.00Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
50.00Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
50.00Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
50.00Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
50.00Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
50.00Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
50.00Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
50.00Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
50.00Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
50.00Single8IWESpermidine8IWE-TA9-Spermidine
50.00Single8IWM2-Phenylethylamine8IWM-TA9-2-Phenylethylamine
50.00Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
50.00Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
50.00Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
50.00Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
50.00Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
50.00Single8WC5Tetramethylammonium Ion8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
50.00Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ2
50.00Single9ARYSerotonin9ARY-5-HT2A-Serotonin-chim(NtGi1-Gs-CtGq)/β1/γ2
50.00Single9K07DSO-5a9K07-BB3-DSO-5a-chim(NtGi2L-Gs-CtGq)/β1/γ2
50.00Single9LRBHistamine9LRB-H1-Histamine-Gs/β1/γ2
50.00Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
50.00Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
50.00Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
50.00Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
50.00Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
50.00Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
50.00Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
50.00Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
50.00Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
50.00Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
50.00Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
50.00Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
50.00Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
50.00Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
50.00Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
50.00Consensusgs_histamineOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
50.00Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
50.00Consensush2_onOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
50.00Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
50.00Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
50.00Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
50.00Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
47.06Single3NY9ICI118-5513NY9-β2-ICI118-551
47.06Single7SK9CCX6627SK9-ACKR3-CCX662
47.06Single8X5YAstemizole8X5Y-H1-Astemizole
46.67Single2YDVNECA2YDV-A2A-NECA
46.67Single3P0GBI1671073P0G-β2-BI167107
46.67Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
46.67Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
46.67Single4UHRCGS216804UHR-A2A-CGS21680
46.67Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
46.67Single5G53NECA5G53-A2A-NECA-Gs
46.67Single5V54Methiothepin5V54-5-HT1B-Methiothepin
46.67Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
46.67Single6WGTLSD6WGT-5-HT2A-LSD
46.67Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
46.67Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
46.67Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
46.67Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
46.67Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
46.67Single8E0GBU728E0G-μ-BU72
46.67Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
46.67Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
46.67Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
46.67Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
46.67Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
46.67Single9BJKNaloxone9BJK-μ-Naloxone-NAM
46.67Consensus5ht1_offOrthosteric Ligand5ht1b_off
46.67Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
46.67Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
46.15Single6A94Zotepine6A94-5-HT2A-Zotepine
46.15Single6KUXRS-799486KUX-α2a-RS-79948
46.15Single6TPGEMPA6TPG-OX2-EMPA
46.15Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
46.15Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
46.15Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
46.15Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
46.15Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
46.15Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
46.15Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
46.15Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
46.15Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
46.15Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
46.15Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
46.15Single9ARXSerotonin9ARX-5-HT2A-Serotonin
46.15Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
46.15Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
46.15Consensusopsins_offOrthosteric Ligandrhodopsin_off
46.15Consensussensory_offOrthosteric Ligandopsins_off
45.45Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
45.45Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
45.45Single8IW72-Phenylethylamine8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
45.45Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
45.45Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
45.45Consensus5ht2_onOrthosteric Ligand5ht2b_on
45.45Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
45.45Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
44.44Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
44.44Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
44.44Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
44.44Single8PKMBefiradol8PKM-5-HT1A-Befiradol-Gi1/β1/γ1
44.44Single9M4TSilodosin9M4T-Alpha1A-Silodosin
43.75Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
43.75Single4RWADIPP-NH24RWA-δ-DIPP-NH2
43.75Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
43.75Single6A93Risperidone6A93-5-HT2A-Risperidone
43.75Single6MXTSalmeterol6MXT-β2-Salmeterol
43.75Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
43.75Single7DFPSpiperone7DFP-D2-Spiperone
43.75Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
43.75Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
43.75Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
43.75Single7YITNalfurafine7YIT-κ-Nalfurafine
43.75Single9EBIPiclidenoson9EBI-A3A-Piclidenoson-chim(NtGi1L-Gs-CtGi1)/β1/γ2
43.75Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
43.75Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
43.75Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
43.75Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
43.75Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
43.75Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
43.75Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
43.75Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
43.75Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
42.86Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
42.86Single2Y01Dobutamine2Y01-β1-Dobutamine
42.86Single2Y02Carmoterol2Y02-β1-Carmoterol
42.86Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
42.86Single4EJ4Naltrindole4EJ4-δ-Naltrindole
42.86Single5DHGC-355DHG-NOP-C-35
42.86Single5DHHSB-6121115DHH-NOP-SB-612111
42.86Single7BU7BI1671077BU7-β1-BI167107
42.86Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
42.86Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
42.86Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
42.86Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
42.86Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
42.86Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
42.86Single8T1WCVN4248T1W-GPR6-CVN424
42.86Single9CHXS-Carazolol9CHX-β2-S-Carazolol
42.86Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
42.86Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
42.86Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
42.86Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
42.86Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
42.86Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
42.86Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
42.86Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
41.67Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
41.67Single3PBLEticlopride3PBL-D3-Eticlopride
41.67Single7V68Iperoxo7V68-M4-Iperoxo-LY2119620-Gi1/β1/γ2
41.67Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
41.67Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
41.67Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
41.67Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
41.67Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
41.67Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
41.67Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
41.67Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
41.67Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
41.67Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
41.67Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
41.67Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
41.18Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
41.18Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
41.18Single5X93K-87945X93-ETB-K-8794
41.18Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
41.18Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
41.18Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
41.18Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
41.18Single9CGJC6-Quino9CGJ-δ-C6-Quino-Gi1/β1/γ2
41.18Consensusendothelin_offOrthosteric Ligandetb_off
41.18Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
40.00Single2Y00Dobutamine2Y00-β1-Dobutamine
40.00Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
40.00Single5TVNLSD5TVN-5-HT2B-LSD
40.00Single5WF5UK-4320975WF5-A2A-UK-432097
40.00Single5WQCEMPA5WQC-OX2-EMPA
40.00Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
40.00Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
40.00Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
40.00Single7LD3Adenosine7LD3-A1-Adenosine-MIPS521-Gi2/β1/γ2
40.00Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
40.00Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
40.00Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
40.00Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
40.00Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
40.00Single8JXSPF-61428JXS-D1-PF-6142
40.00Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
40.00Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
40.00Single8ZMFA1L108ZMF-5-HT2C-A1L10
40.00Single9EE8Adenosine9EE8-A2A-Adenosine-Gs/β1/γ2
40.00Single9I52A1IZU9I52-D1-A1IZU-Gs/β1/γ2
40.00Consensusa3_on_gpOrthosteric Liganda3a_on_gp
40.00Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
40.00Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
38.89Single4UG2CGS216804UG2-A2A-CGS21680
38.89Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
38.89Single6PT3DPI-2876PT3-δ-DPI-287
38.89Single9CGKC5-Quino9CGK-δ-C5-Quino-Gi1/β1/γ2
38.46Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
38.46Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
38.46Single6AKXA4R6AKX-CCR5-A4R
38.46Single6AKYMaraviroc6AKY-CCR5-Maraviroc
38.46Single6TODEMPA6TOD-OX1-EMPA-Na
38.46Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
38.46Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
38.46Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
38.46Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
38.46Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
38.46Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
38.46Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
38.46Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
38.46Single8Y0HVUF114188Y0H-CXCR3-VUF11418
38.46Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go/β1/γ2
38.46Single9EBHAdenosine9EBH-A3A-Adenosine-Gi1/β1/γ2
38.46Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
38.46Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
37.50Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
37.50Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
37.50Single6E59L-7607356E59-NK1-L-760735
37.50Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
37.50Single6J20Aprepitant6J20-NK1-Aprepitant
37.50Single6J21Aprepitant6J21-NK1-Aprepitant
37.50Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
37.50Single7B6WCyclazosin7B6W-α1b-Cyclazosin
37.50Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
37.50Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
37.50Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
37.50Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
37.50Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
37.50Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
37.50Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
37.50Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
37.50Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
37.50Single8XVLZibotentan8XVL-ETA-Zibotentan
37.50Single9I54A1IZV9I54-D1-A1IZV-Gs/β1/γ2
37.50Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
37.50Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
37.50Consensustachykinin_offOrthosteric Ligandnk1_off
36.84Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
36.84Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
36.84Single8WDTphotoNECA8WDT-A2A-photoNECA
36.84Single9BUYLM1899BUY-β2-LM189-Gi1/β1/γ2
36.84Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
36.84Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
36.36Single2HPYAll-trans-Retinal2HPY-Rhodopsin-All-trans-Retinal
36.36Single9EE9Adenosine9EE9-A2A-Adenosine-Gs/β1/γ2
35.71Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
35.71Single2YDOAdenosine2YDO-A2A-Adenosine
35.71Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
35.71Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
35.71Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
35.71Single4MBSMaraviroc4MBS-CCR5-Maraviroc
35.71Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
35.71Single4ZJCSB-6740424ZJC-OX1-SB-674042
35.71Single6IQLL7458706IQL-D4-L745870
35.71Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
35.71Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
35.71Single6TPNHTL66416TPN-OX2-HTL6641
35.71Single6VI4JDTic6VI4-κ-JDTic
35.71Single7F61PF-036547467F61-H3-PF-03654746
35.71Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
35.71Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
35.71Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
35.71Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
35.71Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
35.71Single9JH3CMF-0199JH3-Apelin-CMF-019-Gi1/β1/γ2
35.71Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
35.71Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
35.29Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
35.29Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
35.29Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
35.29Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
35.29Single8JJLOlodaterol8JJL-β2-Olodaterol
35.29Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
35.29Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
35.29Single9M4QDoxazosin9M4Q-Alpha1A-Doxazosin
35.29Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
35.29Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
35.29Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
35.29Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
35.00Single3QAKUK-4320973QAK-A2A-UK-432097
35.00Single6HLOAprepitant6HLO-NK1-Aprepitant
35.00Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
33.33Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
33.33Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
33.33Single3PQRAll-trans-Retinal3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
33.33Single3UZAGTPL92363UZA-A2A-GTPL9236
33.33Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
33.33Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
33.33Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
33.33Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
33.33Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
33.33Single6PT2KGCHM076PT2-δ-KGCHM07
33.33Single6TOTLemborexant6TOT-OX1-Lemborexant
33.33Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
33.33Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
33.33Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
33.33Single7EZCUKA7EZC-A2A-UKA
33.33Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
33.33Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
33.33Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
33.33Single7UL4Alvimopan7UL4-μ-Alvimopan
33.33Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
33.33Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
33.33Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
33.33Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
33.33Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
33.33Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
33.33Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
33.33Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
33.33Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
33.33Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
33.33Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
33.33Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
33.33Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
33.33Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
33.33Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
33.33Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
33.33Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
33.33Single9KFJPubChem 1383196749KFJ-RXFP3-PubChem 138319674-Gi2/β1/γ2
33.33Single9M54Neuropeptide VF9M54-NPFF2-Neuropeptide VF-Gi1/β1/γ2
33.33Consensusa3_onOrthosteric Liganda3a_on
33.33Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
33.33Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
33.33Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
33.33Consensusblt_onOrthosteric Ligandblt1_on
33.33Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
33.33Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
33.33Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
33.33Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
33.33Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
33.33Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
33.33Consensusleukotriene_onOrthosteric Ligandblt_on
33.33Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
33.33Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
33.33Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
33.33Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
33.33Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
33.33Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
31.82Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
31.82Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
31.82Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
31.58Single8Y72Peptide8Y72-μ-Peptide-BMS-986122-Gi1/β1/γ2
31.58Single9M0RNeuropeptide VF9M0R-NPFF1-Neuropeptide VF-Gi1/β1/γ2
31.58Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
31.58Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
31.58Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
31.58Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
31.25Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
31.25Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
31.25Single5CGCHTL142425CGC-mGlu5-HTL14242
31.25Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
31.25Single5XPRBosentan5XPR-ETB-Bosentan
31.25Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
31.25Single6HLPNetupitant6HLP-NK1-Netupitant
31.25Single6LUQHaloperidol6LUQ-D2-Haloperidol
31.25Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
31.25Single6TP6Filorexant6TP6-OX1-Filorexant
31.25Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
31.25Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
31.25Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
31.25Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
31.25Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
31.25Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
31.25Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
31.25Single8S4DCMF-0198S4D-Apelin-CMF-019
31.25Single8XYKVUF106618XYK-CXCR3-VUF10661-Go/β1/γ2
31.25Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
31.25Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
31.25Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
31.25Single9HAPTolvaptan9HAP-V2-Tolvaptan
31.25Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
30.77Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
30.77Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
30.77Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
30.77Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
30.77Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
30.77Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
30.77Single8K5BNiacin8K5B-HCA2-Niacin
30.77Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
30.77Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
30.43Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
30.00Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
30.00Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
30.00Single8GEJConstrained Epinephrine8GEJ-β2-Constrained Epinephrine-Gs/β1/γ2
30.00Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
30.00Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
30.00Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
30.00Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
30.00Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
29.41Single4DJHJDTic4DJH-κ-JDTic
29.41Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
29.41Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
29.41Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
29.41Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
29.41Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
29.41Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
29.41Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
29.41Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
29.41Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
29.41Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
29.41Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
29.41Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
29.41Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
29.41Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
29.41Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
29.41Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
29.41Single9IK9SST analogue9IK9-SST1-SST analogue-Gi1/β1/γ2
29.41Consensusa2_onOrthosteric Liganda2b_on
29.41Consensusa2_on_gpOrthosteric Liganda2b_on_gp
29.41Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
29.41Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
29.41Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
29.41Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
29.41Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
29.41Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
29.17Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
28.57Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
28.57Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
28.57Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
28.57Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
28.57Single4S0VSuvorexant4S0V-OX2-Suvorexant
28.57Single5WS3EMPA5WS3-OX2-EMPA
28.57Single6B73MP11046B73-κ-MP1104
28.57Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
28.57Single6DS0Ly2660976DS0-5-HT2B-Ly266097
28.57Single6ME2Ramelteon6ME2-MT1-Ramelteon
28.57Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
28.57Single6TPJSuvorexant6TPJ-OX2-Suvorexant
28.57Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
28.57Single7F8ULintitript7F8U-CCKA-Lintitript
28.57Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
28.57Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
28.57Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
28.57Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
28.57Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
28.57Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
28.57Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
28.57Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
28.57Single8YYWAlpha-ketoglutarate8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
28.57Single9EEAAdenosine9EEA-A2A-Adenosine-Gs/β1/γ2
28.57Single9K6LSA09K6L-TAS2R16-SA0-Gi2/β1/γ2
28.57Single9KPESA09KPE-TAS2R16-SA0-Gi1/β1/γ2
28.57Consensusangiotensin_offOrthosteric Ligandat1_off
28.57Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
28.57Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
28.57Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
28.57Consensusorexin_offOrthosteric Ligandox2_off ox1_off
28.57Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
28.57Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
28.57Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
28.57Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
28.57Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
28.57Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
28.00Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
28.00Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
28.00Single9KDFRES-701-39KDF-ETB-RES-701-3
27.78Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
27.78Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
27.78Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
27.78Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
27.78Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
27.78Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
27.78Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
27.78Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
27.78Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
27.78Single8JWY2-1188JWY-A2A-2-118
27.78Single8JWZAB9288JWZ-A2A-AB928-Na
27.78Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
27.78Single8XYIVUF106618XYI-CXCR3-VUF10661
27.78Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
27.78Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
27.78Consensusorexin_onOrthosteric Ligandox2_on
27.78Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
27.78Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
27.27Single3PXOAll-trans-Retinal3PXO-Rhodopsin-All-trans-Retinal
27.27Single5DYSAll-trans-Retinal5DYS-Rhodopsin-All-trans-Retinal
27.27Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
27.27Single7WC4Serotonin7WC4-5-HT2A-Serotonin
27.27Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
27.27Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
27.27Single9U4WGonadoliberin-19U4W-GnRH1-Gonadoliberin-1-chim(NtGi1L-Gs-CtGq)/β1/γ2
27.27Consensusangiotensin_onOrthosteric Ligandat1_on
27.27Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
27.27Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
26.67Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
26.67Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
26.67Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
26.67Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
26.67Single6TP3Nemorexant6TP3-OX1-Nemorexant
26.67Single6V9SGTPL114036V9S-OX1-GTPL11403
26.67Single6ZG9GSK10347026ZG9-M1-GSK1034702
26.67Single7T32ZM-2413857T32-A2A-ZM-241385
26.67Single7VODCariprazine7VOD-5-HT2A-Cariprazine
26.67Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
26.67Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
26.67Single8IHKAcifran8IHK-HCA3-Acifran
26.67Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
26.67Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
26.67Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
26.67Single8K5CAcipimox8K5C-HCA2-Acipimox
26.67Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
26.67Single8RLNLUF58348RLN-A2A-LUF5834
26.67Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
26.67Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
26.67Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
26.67Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
26.67Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
26.67Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
26.67Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
26.67Consensushca_onOrthosteric Ligandhca2_on
26.32Single5CGDHTL142425CGD-mGlu5-HTL14242
26.32Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
26.32Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
26.32Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
26.32Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
26.32Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
26.32Single8T3OTUG-8918T3O-FFA4-TUG-891-chim(NtGi2L-Gs-CtGq)/β1/γ2
26.32Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
26.32Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
26.32Single8XVJMacitentan8XVJ-ETA-Macitentan
26.32Consensusfp-alpha_onOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
26.32Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
26.32Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
26.32Consensusprostanoid_offOrthosteric Ligandep_off dp_off
26.09Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
26.09Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
26.09Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
26.09Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
26.09Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
26.09Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
26.09Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
25.93Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
25.93Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
25.93Consensusbombesin_onOrthosteric Ligandbb2_on
25.93Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
25.93Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
25.00Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
25.00Single4YAYZD-71554YAY-AT1-ZD-7155
25.00Single5TGZAM65385TGZ-CB1-AM6538
25.00Single5UIGCmpd-15UIG-A2A-Cmpd-1
25.00Single5WF6UK-4320975WF6-A2A-UK-432097
25.00Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
25.00Single5ZTYAM102575ZTY-CB2-AM10257
25.00Single6GPSMK08126GPS-CCR2-MK0812
25.00Single6OY9All-trans-Retinal6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
25.00Single6XBM5LWE6XBM-SMO-5LWE-Gi1/β1/γ2
25.00Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
25.00Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
25.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
25.00Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
25.00Single7XN9L-054,5227XN9-SST2-L-054,522
25.00Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
25.00Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
25.00Single8CU6LJ-45178CU6-A2A-LJ-4517
25.00Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
25.00Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
25.00Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
25.00Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
25.00Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
25.00Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
25.00Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
25.00Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
25.00Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
25.00Single8K5DGSK2560738K5D-HCA2-GSK256073
25.00Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
25.00Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single8Y02Retinal8Y02-OPN1SW-Retinal-Gi1/β1/γ2
25.00Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
25.00Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
25.00Single9JGKBalovaptan9JGK-5-HT2B-Balovaptan
25.00Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
25.00Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
25.00Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
25.00Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
25.00Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
25.00Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
25.00Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
25.00Consensushca_on_gpOrthosteric Ligandhca2_on_gp
25.00Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
25.00Consensussensory_onOrthosteric Ligandopsins_on
24.00Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
23.81Single7F8XNN90567F8X-CCKA-NN9056
23.81Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
23.81Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
23.81Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
23.81Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
23.81Consensuslpl_onOrthosteric Ligands1p_on lpa_on
23.81Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
23.81Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
23.53Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
23.53Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
23.53Single6D26Fevipiprant6D26-DP2-Fevipiprant
23.53Single6GPXMK08126GPX-CCR2-MK0812
23.53Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
23.53Single7C4SS1P7C4S-S1P3-S1P
23.53Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
23.53Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
23.53Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
23.53Single7SINNPS-21437SIN-CaS-NPS-2143
23.53Single7SINNPS-21437SIN-CaS-NPS-2143
23.53Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
23.53Single7W41PD1762527W41-BB2-PD176252
23.53Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
23.53Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
23.53Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
23.53Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
23.53Single8TF5Oleic acid8TF5-GPR6-Oleic acid
23.53Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
23.53Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
23.53Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
23.53Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
23.53Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
23.53Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
23.53Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
23.53Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
23.53Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
23.53Single9CIBFCH-22964139CIB-HCA2-FCH-2296413
23.53Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
23.53Single9EHSLUF76029EHS-A3A-LUF7602
23.53Consensusadenosine_offOrthosteric Liganda1_off a2_off
23.53Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
23.53Consensusbombesin_offOrthosteric Ligandbb2_off
23.53Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
23.53Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
23.53Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
23.53Consensusdp_offOrthosteric Liganddp2_off
23.53Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
23.53Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
23.53Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
23.08Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
23.08Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
23.08Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
23.08Single7WC5Psilocin7WC5-5-HT2A-Psilocin
23.08Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
23.08Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
23.08Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
23.08Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
23.08Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
23.08Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
23.08Consensusgi_sensoryOrthosteric Ligandgi_opsins
23.08Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
23.08Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
23.08Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
22.73Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
22.73Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
22.73Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
22.73Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
22.73Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
22.73Single9IK8SST analogue9IK8-SST1-SST analogue-Gi1/β1/γ2
22.73Single9IQVMuscarinic toxin 39IQV-Alpha1A-Muscarinic toxin 3
22.73Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
22.73Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
22.22Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
22.22Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
22.22Single5XR8AM8415XR8-CB1-AM841
22.22Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
22.22Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
22.22Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
22.22Single7TUYGSK682753A7TUY-GPR183-GSK682753A
22.22Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
22.22Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
22.22Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
22.22Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
22.22Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
22.22Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
22.22Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
22.22Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
22.22Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
22.22Single8Y73Peptide8Y73-μ-Peptide-MPAM-15-Gi1/β1/γ2
22.22Single8YNTSNAP-948478YNT-MCH1-SNAP-94847
22.22Single8ZWFJR14a8ZWF-C3aB-JR14a
22.22Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
22.22Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
22.22Single9JMCDS-3801b9JMC-Motilin-DS-3801b-chim(Gs-CtGq)/β1/γ2
22.22Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
22.22Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
22.22Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
22.22Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
21.74Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
21.74Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
21.74Single9M1OMorphine-Modulating Neuropeptide B9M1O-NPFF2-Morphine-Modulating Neuropeptide B-Gi1/β1/γ2
21.74Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
21.74Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
21.74Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
21.74Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
21.43Single6HLLCP999946HLL-NK1-CP99994
21.43Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
21.43Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
21.43Single6TP4ACT-4622066TP4-OX1-ACT-462206
21.43Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
21.43Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
21.43Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
21.43Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
21.43Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
21.43Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
21.43Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
21.43Single9B9Y7DY9B9Y-CB1-7DY
21.43Single9EPRRetinal9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
21.43Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
21.43Single9IZDCHBA9IZD-HCA1-CHBA-Gi1/β1/γ2
21.43Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
21.05Single4N4WSANT-14N4W-SMO-SANT-1
21.05Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
21.05Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
21.05Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
21.05Single7K15MKD0467K15-BLT1-MKD046-Na
21.05Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
21.05Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
21.05Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
21.05Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
21.05Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
21.05Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
21.05Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
21.05Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
21.05Single8JD3JNJ-404118138JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
21.05Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
21.05Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.05Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
21.05Single8XJNCloprosetnol8XJN-TXA2-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
21.05Single9DGIZ85267113509DGI-CB1-Z8526711350
21.05Single9GGGI-BOP9GGG-TXA2-I-BOP-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.05Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
21.05Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
21.05Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
21.05Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
21.05Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
21.05Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
21.05Consensuslpa_offOrthosteric Ligandlpa1_off
21.05Consensuslpl_offOrthosteric Ligands1p_off lpa_off
20.83Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
20.83Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
20.83Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
20.83Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
20.83Single8ZBISomatostatin-148ZBI-SST3-Somatostatin-14-Gi1/β1/γ2
20.83Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
20.83Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
20.83Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
20.83Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
20.83Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
20.83Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
20.83Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
20.83Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
20.83Consensusvasop-oxy_onOrthosteric Ligandv2_on
20.83Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
20.00Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
20.00Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
20.00Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
20.00Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
20.00Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
20.00Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
20.00Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
20.00Single6ME9Ramelteon6ME9-MT2-Ramelteon
20.00Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
20.00Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
20.00Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
20.00Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
20.00Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
20.00Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
20.00Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
20.00Single7XRRLemborexant7XRR-OX2-Lemborexant
20.00Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
20.00Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
20.00Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
20.00Single8GNGIstradefylline8GNG-A2A-Istradefylline
20.00Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
20.00Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
20.00Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
20.00Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
20.00Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
20.00Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
20.00Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
20.00Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
20.00Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
20.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
20.00Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
20.00Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
20.00Single8XJOU466198XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
20.00Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
20.00Single8ZWGJR14a8ZWG-C3aB-JR14a-Gi1/β1/γ2
20.00Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
20.00Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
20.00Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
20.00Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
20.00Single9H2XA1IR19H2X-A2A-A1IR1-Na
20.00Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
20.00Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
20.00Single9M1HProstaglandin E29M1H-EP1-Prostaglandin E2-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
20.00Consensuscck_onOrthosteric Ligandccka_on cckb_on
20.00Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
20.00Consensuschemerin_onOrthosteric Ligandcml1_on
20.00Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
20.00Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
20.00Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
20.00Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
20.00Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
20.00Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
20.00Consensustp_onOrthosteric Ligand8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Consensustp_on_gpOrthosteric Ligand8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Consensusvpac1_onOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
19.23Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
19.23Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
19.23Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
19.23Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
19.23Single9KFKRelaxin-39KFK-RXFP4-Relaxin-3-Gi2/β1/γ2
19.23Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
19.23Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
19.23Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
19.23Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
19.23Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
19.23Consensusvpac1_on_gpOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
19.05Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
19.05Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
19.05Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
19.05Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
19.05Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
19.05Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
19.05Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
19.05Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
19.05Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
19.05Single8QJ2pN1628QJ2-MC4-pN162-Gs
19.05Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
19.05Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
19.05Single9IPVJR14a9IPV-C3aB-JR14a-Gi1/β1/γ2
19.05Single9IZASCH9002719IZA-HCA2-SCH900271-Gi1/β1/γ2
19.05Single9V2NMacimorelin9V2N-Ghrelin-Macimorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
19.05Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
19.05Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
19.05Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
19.05Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
19.05Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
18.75Single3REYXAC3REY-A2A-XAC
18.75Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
18.75Single5IU7Q274563465IU7-A2A-Q27456346-Na
18.75Single5IUBQ274563445IUB-A2A-Q27456344-Na
18.75Single5JTBZM-2413855JTB-A2A-ZM-241385
18.75Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
18.75Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
18.75Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
18.75Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
18.75Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
18.75Single6AQFZM-2413856AQF-A2A-ZM-241385
18.75Single6FFIMMPEP6FFI-mGlu5-MMPEP
18.75Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
18.75Single6TPKRetosiban6TPK-OT-Retosiban
18.75Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
18.75Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
18.75Single7AROLUF58337ARO-A2A-LUF5833-Na
18.75Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
18.75Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
18.75Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
18.75Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
18.75Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
18.75Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
18.75Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
18.75Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
18.75Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
18.75Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
18.75Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.75Single8Y6YGLPG09748Y6Y-FFA2-GLPG0974
18.75Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
18.75Single8ZPMAMD0708ZPM-CXCR4-AMD070
18.75Single8ZPNAMD31008ZPN-CXCR4-AMD3100
18.75Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
18.75Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
18.75Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
18.75Single9BA0A1AKN9BA0-CB1-A1AKN
18.75Single9JMDAzithromycin9JMD-Motilin-Azithromycin-chim(Gs-CtGq)/β1/γ2
18.75Single9KPDSA09KPD-TAS2R16-SA0-chim(Gs-CtGt3)/β1/γ2
18.75Single9M2FNeuropeptide FF9M2F-NPFF1-Neuropeptide FF-Gi1/β1/γ2
18.75Consensusa2_offOrthosteric Liganda2a_off
18.75Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
18.75Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
18.75Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
18.75Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
18.75Consensusvasop-oxy_offOrthosteric Ligandot_off
18.52Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
18.52Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
18.52Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
18.52Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
18.52Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
18.52Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
18.52Single9BUCCagrilintide9BUC-CT-Cagrilintide-Gs/β1/γ2
18.52Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
18.52Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
18.18Single4A4MAll-trans-Retinal4A4M-Rhodopsin-All-trans-Retinal-Gt(CT)
18.18Single5EN0All-trans-Retinal5EN0-Rhodopsin-All-trans-Retinal-Gt(CT)
18.18Single5MZPCaffeine5MZP-A2A-Caffeine-Na
18.18Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
18.18Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
18.18Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
18.18Single7QA8Peptide7QA8-STE2-Peptide
18.18Single7QA8Peptide7QA8-STE2-Peptide
18.18Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
18.18Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
18.18Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
18.18Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
18.18Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
18.18Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
18.18Single8IEBA1LYA8IEB-GPR156-A1LYA
18.18Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
18.18Single8WKYPG-9348WKY-MC4-PG-934
18.18Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
18.18Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
18.18Single8ZBJSomatostatin-148ZBJ-SST5-Somatostatin-14-Gi1/β1/γ2
18.18Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
18.18Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
18.18Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
18.18Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
18.18Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
17.86Single6IGLIRL16206IGL-ETB-IRL1620
17.86Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
17.86Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
17.86Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
17.86Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
17.86Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
17.86Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
17.86Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
17.86Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
17.86Consensusbradykinin_onOrthosteric Ligandbk2_on
17.86Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
17.86Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
17.65Single3EMLZM-2413853EML-A2A-ZM-241385
17.65Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
17.65Single5IU8Q274563475IU8-A2A-Q27456347-Na
17.65Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
17.65Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
17.65Single5UENDU1725UEN-A1-DU172
17.65Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
17.65Single6D27CAY104716D27-DP2-CAY10471
17.65Single6FFHFenobam6FFH-mGlu5-Fenobam
17.65Single6IIVDaltroban6IIV-TXA2-Daltroban
17.65Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
17.65Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
17.65Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
17.65Single6S0LZM-2413856S0L-A2A-ZM-241385
17.65Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
17.65Single7PYRPSB-21157PYR-A2A-PSB-2115
17.65Single7V3ZCP559407V3Z-CB1-CP55940
17.65Single7YXAONO-54306087YXA-S1P5-ONO-5430608
17.65Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
17.65Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
17.65Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
17.65Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
17.65Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
17.65Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
17.65Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
17.65Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
17.65Single9H37A1IR09H37-A2A-A1IR0-Na
17.65Single9IZCMK19039IZC-HCA2-MK1903-Gi1/β1/γ2
17.65Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
17.65Consensuscck_offOrthosteric Ligandccka_off
17.65Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
17.65Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
17.65Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
17.65Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
17.65Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
17.39Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
17.39Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
17.39Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
17.39Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
17.39Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
17.39Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
17.39Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
17.39Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
17.39Single9E82SDF-1-beta9E82-ACKR3-SDF-1-β-Arrestin2
17.39Single9KFIRelaxin-39KFI-RXFP3-Relaxin-3-Gi2/β1/γ2
17.39Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
17.39Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
17.39Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
17.39Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
17.39Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
17.39Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
17.39Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
17.39Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
17.24Consensuscrf1_onOrthosteric Ligand6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF1-Corticoliberin-Gs/β1/γ2
17.24Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
16.67Single4NTJAZD12834NTJ-P2Y12-AZD1283
16.67Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
16.67Single5IUAQ274563485IUA-A2A-Q27456348-Na
16.67Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
16.67Single5N2RPSB-365N2R-A2A-PSB-36-Na
16.67Single5N2SPSB365N2S-A1-PSB36
16.67Single5T1ABMS-6815T1A-CCR2-BMS-681-PubChem 12093170
16.67Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
16.67Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
16.67Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
16.67Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
16.67Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
16.67Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
16.67Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
16.67Single6S0QZM-2413856S0Q-A2A-ZM-241385
16.67Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
16.67Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
16.67Single6W25SHU91196W25-MC4-SHU9119-Ca
16.67Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
16.67Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
16.67Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
16.67Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
16.67Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
16.67Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
16.67Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
16.67Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
16.67Single8GNEKW-63568GNE-A2A-KW-6356-Na
16.67Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
16.67Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
16.67Single8PWNTheophylline8PWN-A2A-Theophylline
16.67Single8QOTNanobody-E8QOT-μ-Nanobody-E
16.67Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
16.67Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
16.67Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
16.67Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
16.67Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
16.67Single8ZVZBW245C8ZVZ-DP1-BW245C-Gs/β1/γ2
16.67Single9B9ZA1AKO9B9Z-CB1-A1AKO
16.67Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
16.67Single9GE2ML1849GE2-GPR55-ML184-chim(NtGi1-G13)/β1/γ2
16.67Single9HC04YI9HC0-mGlu5-4YI
16.67Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
16.67Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
16.67Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
16.67Single9KPFSA09KPF-TAS2R16-SA0-Gi1/β1/γ2
16.67Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
16.67Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
16.67Consensusblt_offOrthosteric Ligandblt1_off
16.67Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
16.67Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
16.67Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
16.67Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
16.67Consensusep_offOrthosteric Ligandep4_off
16.67Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
16.67Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
16.67Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
16.67Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
16.67Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
16.67Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
16.13Consensuscrf1_on_gpOrthosteric Ligand6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF1-Corticoliberin-Gs/β1/γ2
16.13Consensusglp1_on_gpOrthosteric Ligand7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
16.13Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
16.00Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
16.00Single6JODAngiotensin II6JOD-AT2-Angiotensin II
16.00Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
16.00Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
16.00Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
16.00Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
16.00Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
16.00Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
16.00Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
16.00Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
16.00Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
16.00Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
16.00Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
16.00Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
16.00Single9BLCCagrilintide backbone (non-acylated)9BLC-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
16.00Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
16.00Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
16.00Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
15.79Single5TZRMK86665TZR-FFA1-MK8666
15.79Single5XRAAM115425XRA-CB1-AM11542
15.79Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
15.79Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
15.79Single7P2L4YI7P2L-mGlu5-4YI
15.79Single7PX4PSB-21137PX4-A2A-PSB-2113
15.79Single7R0CAVP7R0C-V2-AVP-Arrestin2
15.79Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
15.79Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
15.79Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
15.79Single8GDBPGE28GDB-EP4-PGE2-Gs/β1/γ2
15.79Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
15.79Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
15.79Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
15.79Single8JD5JNJ-40411813; ADX881788JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
15.79Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
15.79Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
15.79Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
15.79Single8ZW0PGD28ZW0-DP1-PGD2-Gs/β1/γ2
15.79Single9EGOYVF9EGO-CB1-YVF-Gi1/β1/γ2
15.79Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
15.62Consensusclass-a_class-b1_cons_on_gpOrthosteric Ligandclass-a_on_gp class-b1_on_gp
15.38Single3OE8IT1t3OE8-CXCR4-IT1t
15.38Single3RFMCaffeine3RFM-A2A-Caffeine
15.38Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
15.38Single6TQ9SB-4081246TQ9-OX1-SB-408124
15.38Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
15.38Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
15.38Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
15.38Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
15.38Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
15.38Single8A2OTheophylline8A2O-A2A-Theophylline-Na
15.38Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
15.38Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
15.38Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.38Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
15.38Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
15.38Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
15.38Single8ZRTET-18ZRT-ETB-ET-1
15.38Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
15.38Single9JFYhNPSF9JFY-NPFF2-hNPSF-Gi1/β1/γ2
15.00Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
15.00Single5TZYMK8666; AP85TZY-FFA1-MK8666; AP8
15.00Single5X33BIIL2605X33-BLT1-BIIL260
15.00Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
15.00Single6IIURamatroban6IIU-TXA2-Ramatroban
15.00Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
15.00Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
15.00Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
15.00Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
15.00Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
15.00Single9AU0BW245C9AU0-DP1-BW245C-Gs/β1/γ2
15.00Single9BJKNAM9BJK-μ-Naloxone-NAM
15.00Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
15.00Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
15.00Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
15.00Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
15.00Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
15.00Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
15.00Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
14.81Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
14.81Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
14.81Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
14.81Single9BLWCagrilintide backbone (non-acylated)9BLW-CT (AMY1)-Cagrilintide backbone (non-acylated)-Gs/β1/γ2; RAMP1
14.81Consensuscrf2_on_gpOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
14.81Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
14.81Consensuspac1_onOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
14.81Consensuspac1_on_gpOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
14.81Consensuspac_on_gpOrthosteric Ligandpac1_on_gp
14.81Consensussecretin_onOrthosteric Ligand7D3S-Secretin-Secretin-Gs/β1/γ2
14.29Single3OE6IT1t3OE6-CXCR4-IT1t
14.29Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
14.29Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
14.29Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
14.29Single6K1QIRL25006K1Q-ETB-IRL2500
14.29Single6ME5Agomelatine6ME5-MT1-Agomelatine
14.29Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
14.29Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
14.29Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
14.29Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
14.29Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
14.29Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
14.29Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
14.29Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
14.29Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
14.29Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
14.29Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
14.29Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
14.29Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
14.29Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
14.29Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
14.29Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
14.29Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
14.29Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
14.29Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
14.29Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
14.29Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
14.29Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
14.29Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
14.29Single9GG5U466199GG5-TXA2-U46619-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
14.29Single9JHJC18:0 Ceramide9JHJ-FPR2-ALX-C18:0 Ceramide-Gi1/β1/γ2
14.29Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
14.29Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
14.29Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
14.29Consensusclass-b1_onOrthosteric Ligandglucagon_on vip-pacap_on pth_on crf_on calcitonin_on
14.29Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
14.29Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
14.29Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
14.29Consensusglp_onOrthosteric Ligandglp1_on glp2_on
14.29Consensusglp_on_gpOrthosteric Ligandglp1_on_gp glp2_on_gp
14.29Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
14.29Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
14.29Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
14.29Consensuspth2_on_gpOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
14.29Consensussecretin_on_gpOrthosteric Ligand7D3S-Secretin-Secretin-Gs/β1/γ2
13.79Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
13.79Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
13.79Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
13.79Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
13.79Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
13.79Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
13.79Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
13.79Single9BYOExendin-39BYO-GLP-1-Exendin-3-Gs/β1/γ2
13.79Consensusendothelin_onOrthosteric Ligandetb_on eta_on
13.79Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
13.79Consensusvip-pacap_onOrthosteric Ligandvpac_on pac_on
13.79Consensusvip-pacap_on_gpOrthosteric Ligandvpac_on_gp pac_on_gp
13.64Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
13.64Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
13.64Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
13.64Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
13.64Single9IPYJR14a9IPY-C3aB-JR14a
13.64Single9JF4PD1683689JF4-BB1-PD168368
13.64Single9JH6C20:0 Ceramide9JH6-CysLT2-C20:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
13.64Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
13.64Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
13.64Consensuskisspeptin_onOrthosteric Ligandkiss1_on
13.33Single3OE9IT1t3OE9-CXCR4-IT1t
13.33Single5GLHEndothelin-15GLH-ETB-Endothelin-1
13.33Single5L7IVismodegib5L7I-SMO-Vismodegib
13.33Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
13.33Single6IGKEndothelin-36IGK-ETB-Endothelin-3
13.33Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
13.33Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
13.33Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
13.33Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
13.33Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
13.33Single7XP6Strychnine7XP6-TAS2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
13.33Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
13.33Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab
13.33Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.33Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
13.33Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
13.33Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
13.33Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
13.33Consensusclass-a_class-b1_cons_onOrthosteric Ligandclass-a_on class-b1_on
13.33Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
13.33Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
13.33Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
13.04Single4XT1Fractalkine4XT1-US28-Fractalkine
13.04Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
13.04Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
13.04Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
13.04Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
13.04Single8KIGSHU91198KIG-MC3-SHU9119-Ca
13.04Single8U4OCXCL128U4O-CXCR4-CXCL12-Gi1/β1/γ2
13.04Single8YWFRetatrutide8YWF-GLP-1-Retatrutide-chim(NtGi1-Gs)/β1/γ2
13.04Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
13.04Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
13.04Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
13.04Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
13.04Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
13.04Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
13.04Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
12.90Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
12.90Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
12.90Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
12.90Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
12.90Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
12.90Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
12.90Consensusglp1_onOrthosteric Ligand7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
12.90Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
12.90Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
12.82Consensusclass-b1_on_gpOrthosteric Ligandglucagon_on_gp vip-pacap_on_gp pth_on_gp crf_on_gp calcitonin_on_gp
12.50Single3ODUIT1t3ODU-CXCR4-IT1t
12.50Single3PWHZM-2413853PWH-A2A-ZM-241385
12.50Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
12.50Single5U09Taranabant5U09-CB1-Taranabant
12.50Single5ZKQABT-4915ZKQ-PAF-ABT-491
12.50Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
12.50Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
12.50Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
12.50Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
12.50Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
12.50Single7BR3Elagolix7BR3-GnRH1-Elagolix
12.50Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
12.50Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
12.50Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
12.50Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
12.50Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
12.50Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
12.50Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
12.50Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
12.50Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
12.50Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
12.50Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
12.50Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
12.50Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
12.50Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Single8U4PAMD31008U4P-CXCR4-AMD3100-Gi1/β1/γ2
12.50Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
12.50Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
12.50Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
12.50Single9IQRMuscarinic toxin 39IQR-α2a-Muscarinic toxin 3
12.50Single9IQSMuscarinic toxin 39IQS-M4-Muscarinic toxin 3
12.50Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
12.50Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
12.50Consensuscrf_on_gpOrthosteric Ligandcrf2_on_gp crf1_on_gp
12.50Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
12.50Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
12.50Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
12.50Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
12.50Consensuspth1_on_gpOrthosteric Ligand6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
12.12Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
12.12Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
12.12Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
12.12Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
12.12Consensusglucagon_onOrthosteric Ligandglp_on gluc_on secretin_on gip_on
12.12Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
12.00Single3OE0CVX153OE0-CXCR4-CVX15
12.00Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
12.00Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
12.00Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
12.00Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
12.00Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.00Single8W8YGamma-MSH8W8Y-MC3-γ-MSH-Ca-Gs/β1/γ2
12.00Consensusclass-b1_class-b2_cons_onOrthosteric Ligandclass-b1_on class-b2_on
12.00Consensusclass-b1_class-b2_cons_on_gpOrthosteric Ligandclass-b1_on_gp class-b2_on_gp
12.00Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
12.00Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
12.00Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
11.76Single5UVIZM-2413855UVI-A2A-ZM-241385
11.76Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
11.76Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
11.76Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
11.76Single6MH8ZM-2413856MH8-A2A-ZM-241385
11.76Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
11.76Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
11.76Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
11.76Single8IYXYL-3658IYX-GPR34-YL-365
11.76Single8K2WAMG4878K2W-CXCR3-AMG487
11.76Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
11.76Single8K9LDamgo8K9L-μ-Damgo-BMS-986122-Gi3/β1/γ1
11.76Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
11.76Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
11.76Single9IXXLTD49IXX-CysLT2-LTD4-chim(NtGi1-Gs-CtGq)/β1/γ2
11.76Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Gi1/β1/γ2
11.76Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
11.76Consensusglucagon_on_gpOrthosteric Ligandglp_on_gp gluc_on_gp secretin_on_gp gip_on_gp
11.76Consensusgrh_offOrthosteric Ligandgnrh1_off
11.76Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
11.76Consensuspth_onOrthosteric Ligandpth1_on pth2_on
11.54Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
11.54Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
11.54Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
11.54Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
11.54Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
11.54Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
11.54Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
11.54Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ2
11.54Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
11.54Single9BUDCagrilintide9BUD-CT-Cagrilintide-Gs/β1/γ2
11.54Single9EBOGLP-1 (ACPC18)9EBO-GLP-1-GLP-1 (ACPC18)-Gs/β1/γ2
11.54Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
11.54Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
11.54Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
11.54Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
11.43Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
11.43Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
11.11Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
11.11Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
11.11Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
11.11Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
11.11Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
11.11Single7F83PF-051904577F83-Ghrelin-PF-05190457
11.11Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
11.11Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
11.11Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
11.11Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
11.11Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
11.11Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
11.11Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
11.11Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
11.11Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
11.11Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
11.11Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
11.11Single9IYAONO-97105319IYA-GPR55-ONO-9710531
11.11Consensuscalcitonin_onOrthosteric Ligandctlike_on
11.11Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
11.11Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
11.11Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
11.11Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
11.11Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
11.11Consensuspac_onOrthosteric Ligandpac1_on
11.11Consensusvpac_onOrthosteric Ligandvpac1_on vpac2_on
10.81Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
10.71Single4XT3Fractalkine4XT3-US28-Fractalkine
10.71Single6FJ3PTH6FJ3-PTH1-PTH
10.71Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
10.71Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
10.71Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
10.71Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
10.71Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
10.71Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
10.71Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
10.71Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
10.71Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
10.71Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
10.71Single9BLBCagrilintide backbone (non-acylated)9BLB-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
10.71Single9BP3Cagrilintide9BP3-CT (AMY1)-Cagrilintide-Gs/β1/γ2; RAMP1
10.71Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
10.71Consensuscalcitonin_on_gpOrthosteric Ligandctlike_on_gp
10.71Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
10.71Consensusvpac_on_gpOrthosteric Ligandvpac1_on_gp vpac2_on_gp
10.53Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
10.53Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.53Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
10.53Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
10.53Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
10.53Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
10.53Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
10.53Single8WGBVU01550418WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
10.53Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
10.53Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
10.53Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
10.53Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
10.53Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
10.53Consensuspth_on_gpOrthosteric Ligandpth1_on_gp pth2_on_gp
10.53Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
10.53Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
10.34Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
10.34Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
10.34Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
10.34Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
10.34Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
10.34Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
10.34Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
10.34Single8W8WAlpha-MSH8W8W-MC3-α-MSH-Ca-Gs/β1/γ2
10.34Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
10.34Consensusglp2_on_gpOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
10.00Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
10.00Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
10.00Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
10.00Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
10.00Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
10.00Single7FEECP559407FEE-CB1-CP55940-ZCZ011
10.00Single7T9NDPPC7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
10.00Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
10.00Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
10.00Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
10.00Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
10.00Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
10.00Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
10.00Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
10.00Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
10.00Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
10.00Single8IY6Endothelin-18IY6-ETB-Endothelin-1
10.00Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
10.00Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
10.00Single9CLWTUG-13759CLW-FFA2-TUG-1375-4-CMTB-chim(NtGi1L-Gs-CtGq)/β1/γ2
10.00Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
10.00Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Single9UY3Anamorelin9UY3-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Consensusctlike_on_gpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
10.00Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
10.00Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
10.00Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
10.00Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
10.00Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
10.00Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
10.00Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
10.00Consensuslpa_onOrthosteric Ligandlpa1_on
10.00Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
10.00Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
10.00Consensuspth1_onOrthosteric Ligand6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
10.00Consensusrelaxin_onOrthosteric Ligandrxfp4_on
10.00Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
10.00Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
10.00Consensusvpac2_on_gpOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
9.76Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
9.68Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
9.68Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
9.68Consensusgip_onOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
9.68Consensusgip_on_gpOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
9.52Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
9.52Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
9.52Single6KQICP559406KQI-CB1-CP55940-Org27569
9.52Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
9.52Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
9.52Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
9.52Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
9.52Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
9.52Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
9.52Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
9.52Single8Y6WTUG-13758Y6W-FFA2-TUG-1375-4-CMTB-Gi1/β1/γ2
9.52Single9CM3TUG-13759CM3-FFA2-TUG-1375-Compound 187-chim(NtGi1L-Gs-CtGq)/β1/γ2
9.52Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
9.52Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
9.52Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
9.38Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
9.38Single9AUCCalcitonin gene-related peptide-19AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
9.09Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
9.09Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
9.09Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
9.09Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
9.09Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
9.09Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
9.09Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
9.09Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
9.09Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
9.09Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
9.09Single9C0KExendin-49C0K-GLP-1-Exendin-4-Gs/β1/γ2
9.09Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
9.09Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
8.82Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
8.82Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
8.70Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
8.70Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
8.70Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
8.70Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
8.70Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
8.70Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
8.70Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
8.70Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
8.70Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
8.70Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
8.70Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
8.70Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
8.70Single9CM7TUG-13759CM7-FFA2-TUG-1375-AZ-1729-Gi1/β1/γ2
8.70Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
8.70Single9NS9TUG-13759NS9-FFA2-TUG-1375-Compound 187-Gi1/β1/γ2
8.70Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
8.70Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
8.57Consensusgluc_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
8.33Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
8.33Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
8.33Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
8.33Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
8.33Single8IEIA1LYA8IEI-GPR156-A1LYA
8.33Single8IEIA1LYA8IEI-GPR156-A1LYA
8.33Single8IEPA1LYA8IEP-GPR156-A1LYA
8.33Single8IEPA1LYA8IEP-GPR156-A1LYA
8.33Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
8.33Single9HB3Mambaquaretin-19HB3-V2-Mambaquaretin-1
8.33Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
8.33Consensusgluc_on_gpOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
8.33Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Consensussomatostatin_offOrthosteric Ligandsst2_off
8.00Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
8.00Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
8.00Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
8.00Single7SK5CXCL127SK5-ACKR3-CXCL12
8.00Single7XNACYN1548067XNA-SST2-CYN154806
8.00Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
8.00Single8IEBA1LYA8IEB-GPR156-A1LYA
8.00Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
8.00Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
8.00Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
8.00Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
8.00Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
8.00Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
7.69Single7V68LY21196207V68-M4-Iperoxo-LY2119620-Gi1/β1/γ2
7.69Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
7.69Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
7.69Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
7.69Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
7.69Single9B5YLong-Acting PTH9B5Y-PTH1-Long-Acting PTH-chim(NtGi1-Gq)/β1/γ2
7.69Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
7.69Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
7.69Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
7.69Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
7.69Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
7.41Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
7.41Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
7.41Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
7.41Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
7.14Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
7.14Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
7.14Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
7.14Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
7.14Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
7.14Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
6.90Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
6.90Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
6.90Single7SK3CXCL127SK3-ACKR3-CXCL12
6.90Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
6.90Single9BUBCagrilintide9BUB-CT-Cagrilintide-Gs/β1/γ2
6.90Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
6.90Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
6.67Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
6.67Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
6.67Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/β1/γ2
6.67Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
6.67Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
6.67Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
6.67Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
6.67Single8W8XBeta-MSH8W8X-MC3-β-MSH-Ca-Gs/β1/γ2
6.67Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
6.45Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
6.45Single9BQ3Cagrilintide9BQ3-CT (AMY2)-Cagrilintide-Gs/β1/γ2; RAMP2
6.45Single9BTWCagrilintide9BTW-CT (AMY3)-Cagrilintide-Gs/β1/γ2; RAMP3
6.25Single6LI0C176LI0-GPR52-C17
6.25Single7RBTTirzepatide7RBT-GIP-Tirzepatide-LSN3556672-chim(NtGi1-Gs)/β1/γ2
6.25Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
6.25Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
6.25Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
6.25Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
6.25Single8YKDDehydroepiandrosterone8YKD-ADGRG2-Dehydroepiandrosterone-chim(NtGi1-Gs)/β1/γ2
6.25Single9JCPLPC9JCP-GPR4-LPC-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25Single9LMPNE52-QQ579LMP-GPR4-NE52-QQ57
6.06Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
6.06Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
5.88Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
5.88Single7F8YDevazepide7F8Y-CCKA-Devazepide
5.88Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.88Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
5.88Single7VVOPTH7VVO-PTH1-PTH-Gs/β1/γ2
5.88Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
5.88Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
5.88Single8T3VDocosa-4,7,10,13,16,19-Hexaenoic acid8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.88Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
5.71Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
5.56Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
5.56Single7T94LY21196207T94-M2-Acetylcholine-LY2119620-chim(NtGi1-Go)/β1/γ2
5.56Single7UTZDPPC7UTZ-TSH-TR1402-DPPC-Gs/β1/γ2
5.56Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
5.56Single8JD6VU03647708JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
5.56Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
5.56Single9JFUNE52-QQ579JFU-GPR4-NE52-QQ57
5.56Single9K0KUTP9K0K-P2Y4-UTP-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56Single9K0XATP9K0X-P2Y2-ATP-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56Single9K20ATP9K20-P2Y2-ATP-chim(NtGi1-Go)/β1/γ2
5.56Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
5.56Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
5.26Single4QIMANTA XV4QIM-SMO-ANTA XV
5.26Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
5.26Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
5.26Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
5.26Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
5.26Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
5.26Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
5.00Single4JKVTaladegib4JKV-SMO-Taladegib
5.00Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
5.00Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
5.00Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
5.00Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
4.76Single5V56TC1145V56-SMO-TC114
4.76Single5V57TC1145V57-SMO-TC114
4.76Single6OS1TRV0266OS1-AT1-TRV026
4.76Single7F1TMIP-1a7F1T-CCR5-MIP-1a
4.76Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
4.76Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Single8JD5JNJ-40411813; ADX881788JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
4.76Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
4.76Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
4.76Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Gi1/β1/γ1
4.76Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
4.55Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
4.55Single4PY02MeSATP4PY0-P2Y12-2MeSATP
4.55Single6OS2TRV0266OS2-AT1-TRV026
4.55Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
4.55Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
4.55Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
4.55Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
4.55Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
4.35Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
4.35Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
4.35Single8XVUCXCL28XVU-CXCR2-CXCL2
4.35Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
4.35Single8ZPLHF511168ZPL-CXCR4-HF51116
4.35Single9JH5C16:0 Ceramide9JH5-CysLT2-C16:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17Single5TZYMK8666; AP85TZY-FFA1-MK8666; AP8
4.17Single6KNMJN241-96KNM-Apelin-JN241-9
4.17Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.17Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
4.17Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
4.17Single8XQJJN2418XQJ-Apelin-JN241
4.17Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
4.17Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
4.17Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
4.17Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
4.00Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
4.00Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
4.00Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
4.00Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
4.00Single8XWNCXCL88XWN-CXCR2-CXCL8
4.00Single9BUECagrilintide9BUE-CT-Cagrilintide-Gs/β1/γ2
4.00Single9J0IUDP-Glucuronic acid9J0I-P2Y14-UDP-Glucuronic acid-Gi1/β1/γ2
3.85Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
3.85Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
3.85Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
3.85Single9J0FNADH9J0F-P2Y14-NADH-Gi1/β1/γ2
3.70Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
3.70Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
3.70Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
3.70Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
3.57Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
3.45Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
3.45Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
3.33Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
2.78Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2

Consensus Members
Id Members
7DFL 7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
Net Summary
Imin 2.65
Number of Linked Nodes 848
Number of Links 1067
Number of Hubs 174
Number of Links mediated by Hubs 643
Number of Communities 27
Number of Nodes involved in Communities 271
Number of Links involved in Communities 406
Path Summary
Number Of Nodes in MetaPath 116
Number Of Links MetaPath 115
Number of Shortest Paths 1230188
Length Of Smallest Path 3
Average Path Length 26.6297
Length of Longest Path 53
Minimum Path Strength 1.25
Average Path Strength 5.88483
Maximum Path Strength 23.02
Minimum Path Correlation 0.7
Average Path Correlation 0.979142
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.77778
Average % Of Corr. Nodes 46.2825
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 47.5752
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following differences:
Id1st Network2nd Network
h1_off_on_gph1_on_gph1_off
This network is also present in following consensuses:
IdComponents
histamine_on_gph1_on_gp
h2_on_gp
h3_on_gp
h4_on_gp



You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download h1_on_gp.zip



You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.



You can also  read or  download a guide explaining the meaning of all files and numerical data.