Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
1G.hns1.01 8.26167434
2G.S1.03 9.03439
3G.H1.01 2.27667509
4G.S2.06 4.704509
5G.S3.01 6.83495
6G.S3.03 6.8175408
7G.S3.04 8.27083437
8G.S3.06 9.33733537
9G.S3.07 3.235409
10G.H2.01 7.55449
11G.H2.06 7.63733549
12G.H2.07 8.75167449
13G.h2s4.01 11.3892439
14G.H3.03 4.5175404
15G.H3.09 6.28143759
16G.H3.13 10.7747556
17G.H3.17 10.3472675
18G.S5.03 5.1925409
19G.S5.05 5.302786119
20G.HG.03 4.26833406
21G.hgh4.01 5.33833406
22G.hgh4.02 5.3685178
23G.hgh4.04 5.225335176
24G.hgh4.05 10.9313506
25G.hgh4.11 4.24083405
26G.hgh4.20 5.22667403
27G.H4.03 4.18417404
28G.H4.07 12.0592455
29G.H4.08 7.99467553
30G.H4.10 11.28275177
31G.H4.12 8.48533554
32G.H4.14 7.305335175
33G.H4.15 10.7608408
34G.H4.16 6.92454
35G.h4s6.02 5.29333457
36G.h4s6.20 15.93754184
37G.S6.02 11.125188
38G.S6.05 12.3413555
39G.s6h5.01 6.83254119
40G.H5.03 6.813335119
41G.H5.06 6.125335114
42G.H5.08 7.87333598
43G.H5.17 12.32935185
44G.H5.19 5.49583408
45G.H5.20 4.61417408
46G.H5.23 8.920675154
47G.H5.25 4.62917408
48b.1x3 1.906674248
49b.h2x1 4.56917405
50b.lhb1x6 3.54333403
51b.b1x6 9.62417419
52b.l1x3 10.338519
53b.l1x6 13.4267479
54b.b2x3 5.20333416
55b.b2x5 7.396517
56b.l3x1 9.15167409
57b.l3x2 7.02133539
58b.b4x4 8.55583418
59b.b4x6 10.1348719
60b.b4x7 9.66417418
61b.b5x2 8.785417
62b.b5x3 7.47222619
63b.b5x5 6.383334135
64b.b5x7 5.7025407
65b.l5x1 4.16754198
66b.l5x5 9.73905739
67b.b6x1 5.925409
68b.b6x5 4.767335136
69b.b7x1 7.1175404
70b.l7x4 4.42667409
71b.b8x4 6.65196
72b.l8x1 5.778334135
73b.b9x3 5.0425406
74b.b9x4 7.08667409
75b.l9x3 9.295109
76b.l9x6 8.04056648
77b.b10x5 5.43429709
78b.l10x1 7.04417403
79b.b11x4 6.221674109
80b.l11x2 9.56254109
81b.b12x6 9.962226108
82b.b13x7 9.2625487
83b.l13x3 7.86778689
84b.l13x6 7.8175449
85b.l13x7 5.56917489
86b.b15x2 8.45833466
87b.l15x2 5.98417409
88b.b16x4 9.382586
89b.b16x5 6.25417405
90b.b16x6 8.62143788
91b.b17x5 7.73583467
92b.b17x7 9.3475468
93b.l17x3 8.4181769
94b.l17x6 7.76667549
95b.b18x3 5.22167468
96b.l18x1 7.003896216
97b.l18x3 9.05405
98b.b19x2 9.8225466
99b.b19x4 6.87333468
100b.l19x1 5.82833449
101b.l19x2 8.92417469
102b.b20x4 10.9517408
103b.b20x6 8.235466
104b.b20x7 5.77167409
105b.b21x1 7.778567
106b.b21x2 3.18506
107b.b21x5 4.96833404
108b.b21x7 6.4505
109b.l22x5 5.876509
110b.b23x6 9.20667607
111b.l23x1 6.234576
112b.b24x3 4.50667405
113b.b24x5 3.02417405
114b.l24x2 5.7375406
115b.l24x3 5.48333405
116b.l25x3 11.43174129
117b.l25x6 13.3093578
118b.l26x1 6.5417
119b.l26x5 6.365415
120b.l27x1 13.4257779
121b.l27x2 9.000834129
122b.b28x2 7.39917404
123b.b28x3 5.91667517
124b.b28x4 8.7054126
125b.b28x6 12.45584129
126g.h1x1 2.30417402
127g.ctx3 6.85067509
128g.ctx6 4.9406
129g.ctx15 7.92917419
130g.ctx16 5.85286718
1311x35 3.99167407
1321x53 9.534149
1331x60 5.6425409
1342x46 10.65424159
1352x64 7.345429
1363x37 8.48444609
1373x38 6.651674169
1383x39 8.21417409
1393x40 5.855429
1403x42 6.703334167
1413x46 8.7625169
1423x53 7.766674159
143I2.F719 8.912599
144I2.Y722 8.28583436
1454x42 10.6547508
1464x50 9.634169
1474x53 4.58583409
148E2.N752 5.069174228
149E2.Y753 7.666509
150E2.F769 5.86556929
151E2x51 7.7429
1525x35 5.309174227
1535x36 7.17048729
1545x381 4.45417407
1555x40 3.2975429
1565x43 7.51133529
1575x46 3.01667407
1585x47 7.40167429
1595x54 8.8354239
1606x38 3.54917407
1616x40 5.45409
1626x47 9.00083426
1636x52 5.77429
1646x53 9.71714729
1656x60 3.08083428
1667x37 4.514509
1677x41 5.75333529
1687x49 6.95083429
1697x51 7.4765147
1707x54 7.682675149
1717x56 4.74933509
1728x53 6.30083409
173Lig 8.273541620
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1b.b3x6 b.l1x3 59.005513.9467NoYes099
2b.b3x6 b.l3x2 59.1668.83333NoYes099
3b.b4x6 b.l1x3 53.47866.34667YesYes199
4G.hns1.01 b.l3x2 66.01764.21667YesYes349
5G.S1.03 G.hns1.01 68.039120.58YesYes394
6G.S1.03 b.l5x5 68.25114.66667YesYes399
7G.H4.16 G.h4s6.02 10.07024.00333YesYes547
8G.H4.16 I3.Q812 19.301310.2067YesNo048
9G.h4s6.20 I3.Q812 19.432216.91YesNo048
10b.l3x1 b.l5x5 66.78759.49YesYes099
11b.l1x6 b.l3x1 32.470611.7533YesYes099
12b.l1x6 b.l27x1 32.561222.05YesYes799
13G.H3.17 b.l27x1 70.0318.12333YesYes759
14G.H3.16 G.H3.17 76.020416.72NoYes755
15G.H3.16 G.h3s5.01 76.6094.96333NoNo053
16G.h3s5.01 G.h4s6.10 76.69641.58667NoNo033
17G.h4s6.10 I3.R817 76.75711.58667NoNo030
185x65 I3.R817 76.97983.3NoNo090
195x65 6x38 77.0355.07NoYes097
206x38 6x41 77.21284.90667YesNo079
216x41 G.H5.25 77.2674NoYes098
22G.H5.23 G.H5.25 1003.90667YesYes048
23b.b2x1 b.l3x1 33.51599.77NoYes089
24b.b2x1 b.l27x1 37.50015.78667NoYes089
25G.H4.12 G.H4.16 11.27795.26YesYes544
26G.H5.17 G.h4s6.20 17.641125.38YesYes1854
27G.H5.20 G.H5.25 23.67864.15333YesYes088
28G.H5.20 G.H5.26 23.03765.07333YesNo088
29G.H5.21 G.H5.26 11.50434.45333NoNo048
30G.H5.17 G.H5.21 11.4524.97333YesNo054
315x64 G.H5.26 11.50436.18667NoNo088
325x64 G.H5.17 11.45214.6133NoYes085
333x50 G.H5.23 52.38966.73NoYes094
343x53 G.H5.23 47.64367.62YesYes1594
35b.l26x5 g.ctx4 42.63266.15YesNo057
36g.ctx3 g.ctx4 42.29944.29333YesNo097
37g.ctx3 g.ctx6 39.28779.5YesYes096
38b.l22x5 g.ctx6 37.04464.05YesYes096
39b.l22x5 b.l24x2 35.20047.69333YesYes096
40b.h2x1 b.l24x2 34.69873.69YesYes056
41b.b21x5 b.h2x1 28.71645.18YesYes045
42b.b21x5 b.b21x7 27.8556.38667YesYes045
43b.b21x7 b.b24x6 27.506912.2167YesNo058
44b.b23x6 b.b24x6 26.46377.71667YesNo078
45b.b23x6 b.l21x9 24.74912.09YesNo076
46b.b19x5 b.l21x9 24.5754.70333NoNo056
47b.b19x5 b.l17x3 24.40093.71NoYes059
48b.b19x4 b.l17x3 21.7689.58YesYes689
49b.b3x2 b.b4x6 43.86366.83333NoYes159
50b.b2x5 b.b3x2 43.352112.15YesNo175
51b.b18x3 b.b19x4 12.71484.05333YesYes688
52b.b15x2 b.b18x3 12.18086.14YesYes668
53b.b15x2 b.b16x5 11.52194.96667YesYes065
54b.b16x5 b.l14x6 11.26986.92YesNo053
55b.b17x4 b.l14x6 10.5514.04667NoNo053
56b.b16x7 b.b17x4 10.371111.5167NoNo095
57b.b16x7 b.l16x3 10.19118.23NoNo093
58b.b17x2 b.l16x3 10.01116.31333NoNo033
59b.l26x1 b.l26x5 42.40184.01667YesYes175
605x36 Lig 60.641812.2YesYes290
615x36 E2x52 40.53344.60667YesNo098
623x37 E2x52 43.63958.83667YesNo098
633x37 3x41 93.487810.7167YesNo099
643x41 4x53 62.50373.83NoYes099
653x42 4x53 31.52214.71YesYes079
663x42 4x50 31.569911.85YesYes1679
673x46 4x50 32.439713.4333YesYes1699
682x49 3x46 95.67844.30667NoYes099
692x49 3x50 46.87118.19667NoNo099
705x36 5x39 40.382410.49YesNo099
713x37 5x39 40.66965.54YesNo099
723x45 4x53 31.35876.41333NoYes099
733x45 4x491 63.28374.24667NoNo099
743x46 4x491 63.35716.09667YesNo099
753x41 5x42 31.27017.03333NoNo099
763x45 5x42 31.86165.40667NoNo099
772x49 3x53 49.0044.86NoYes099
781x43 7x46 10.88134.71NoNo098
791x43 Lig 11.44458.50667NoYes290
80E2.F769 E2x51 15.10884.67667YesYes299
815x36 E2x51 16.2987.01333YesYes299
82E2.F769 Lig 15.342811.3033YesYes290
832x67 E2.F769 15.512213.1367NoYes099
842x67 E2x50 13.1146.22NoNo099
85b.b2x5 b.l26x1 42.903110.9167YesYes177
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
1x39Lig4.382NoYes9010
1x437x464.712NoNo9912
1x43Lig8.506672NoYes9010
2x603x405.073330NoYes9921
2x643x365.686672YesNo9912
2x64E2.F7698.932YesYes9011
2x64Lig11.192YesYes9010
2x67E2.F76913.13670NoYes0021
3x36E2.F7694.472NoYes9021
3x36E2x518.732NoYes9921
3x403x4410.96332YesNo9812
3x40Lig4.153332YesYes9010
3x445x4316.790NoYes8921
3x446x538.016670NoYes8921
3x476x536.982NoYes9921
3x477x494.986672NoYes9922
E2.F769E2x514.676672YesYes0911
E2.F769Lig11.30332YesYes0010
5x36E2x517.013332YesYes0911
E2x51Lig10.382YesYes9010
5x36E2x524.606672YesNo0812
5x33Lig7.230NoYes0010
5x365x374.472YesNo0612
5x365x3910.492YesNo0712
5x365x403.932YesYes0912
5x36Lig12.22YesYes0010
5x375x404.206672NoYes6922
5x435x476.786672YesYes9912
5x436x574.643332YesNo9012
5x43Lig5.276672YesYes9010
5x476x578.932YesNo9022
6x537x415.012YesYes9911
6x537x4527.87332YesNo9912
6x537x499.856672YesYes9912
6x53Lig6.533332YesYes9010
6x567x414.160NoYes0921
6x60Lig5.542YesYes0010
7x417x458.462YesNo9912
7x41Lig10.13332YesYes9010
5x43NT.L6054.062YesNo9012
5x36NT.R6097.483332YesNo0012
1x397x395.082NoNo9912
E2.D768E2.I7554.22NoNo0012
6x60E3.P8474.053332YesNo0012
E2.T765Lig3.910NoYes0010
E2.F769NT.I6033.766672YesNo0012
6x506x533.750NoYes9921
2x64NT.F6013.573332YesNo9012
3x40NT.L6043.232YesNo9012
E2.D768Lig2.82NoYes0010
E2.F769NT.T5992.593332YesNo0012
E2.F769E2.P7662.406672YesNo0012
6x60E3.N8492.262YesNo0012
E2.F769E2.G7641.506672YesNo0012
7x41NT.G6021.003332YesNo9012
E2.D767E2.D7680.8866670NoNo0021
6x60E3.G8460.472YesNo0012

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Consensusadgrg2_onOrthosteric Ligand7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
25.00Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
25.00Single9LMPNE52-QQ579LMP-GPR4-NE52-QQ57
23.53Single5ZKQABT-4915ZKQ-PAF-ABT-491
23.53Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
23.53Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
23.53Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
23.53Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
23.08Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
23.08Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
22.73Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
22.73Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
22.22Single7VV6C48/807VV6-MRGPRX2-C48/80
22.22Single9JFUNE52-QQ579JFU-GPR4-NE52-QQ57
21.74Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
21.43Single8X9S5alpha-DHT8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
21.43Consensussecretin_onOrthosteric Ligand7D3S-Secretin-Secretin-Gs/β1/γ2
21.05Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
21.05Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
21.05Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
20.83Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
20.83Single8U4OCXCL128U4O-CXCR4-CXCL12-Gi1/β1/γ2
20.83Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
20.83Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
20.69Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
20.69Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
20.69Consensusglp2_on_gpOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
20.69Consensussecretin_on_gpOrthosteric Ligand7D3S-Secretin-Secretin-Gs/β1/γ2
20.59Consensusgluc_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
20.00Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
20.00Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
20.00Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
20.00Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
20.00Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Gi1/β1/γ2
20.00Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
20.00Consensusgluc_on_gpOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
20.00Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
20.00Consensusvpac2_on_gpOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
19.35Consensusgip_onOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
19.35Consensusgip_on_gpOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
19.05Single5XRAAM115425XRA-CB1-AM11542
19.05Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
19.05Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
19.05Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
19.05Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
19.05Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
19.05Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
18.75Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
18.75Single6ME5Agomelatine6ME5-MT1-Agomelatine
18.75Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
18.75Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
18.75Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
18.75Single9JHJC18:0 Ceramide9JHJ-FPR2-ALX-C18:0 Ceramide-Gi1/β1/γ2
18.52Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
18.52Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
18.52Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
18.52Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
18.52Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
18.18Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
18.18Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
18.18Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
18.18Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Single8XWACXCL18XWA-CXCR2-CXCL1
18.18Single8XWSCXCL58XWS-CXCR2-CXCL5
18.18Single8Y6WTUG-13758Y6W-FFA2-TUG-1375-4-CMTB-Gi1/β1/γ2
18.18Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
18.18Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
18.18Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
17.86Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
17.86Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
17.86Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
17.86Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
17.86Consensusvpac1_onOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
17.65Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
17.65Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
17.65Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
17.65Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab
17.65Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg4_on
17.65Consensusadgrg_on_gpOrthosteric Ligandadgrg2_on_gp adgrg4_on_gp
17.65Consensusgq_nucleotideOrthosteric Ligandgq_p2y
17.65Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
17.39Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-SBI-553-chim(NtGi1-Go)/β1/γ2
17.39Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
17.39Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
17.39Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
17.39Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
17.39Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
17.39Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.39Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.24Single6FJ3PTH6FJ3-PTH1-PTH
17.24Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
17.24Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
17.24Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
17.24Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
17.24Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
17.24Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
17.24Consensuspac1_onOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
17.24Consensuspac1_on_gpOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
17.24Consensusvpac1_on_gpOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
16.67Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
16.67Single4UG2CGS216804UG2-A2A-CGS21680
16.67Single5U09Taranabant5U09-CB1-Taranabant
16.67Single5WF6UK-4320975WF6-A2A-UK-432097
16.67Single5ZTYAM102575ZTY-CB2-AM10257
16.67Single6AKYMaraviroc6AKY-CCR5-Maraviroc
16.67Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
16.67Single6KNMJN241-96KNM-Apelin-JN241-9
16.67Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
16.67Single6ME9Ramelteon6ME9-MT2-Ramelteon
16.67Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
16.67Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
16.67Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
16.67Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
16.67Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single7SK9CCX6627SK9-ACKR3-CCX662
16.67Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
16.67Single7VVOPTH7VVO-PTH1-PTH-Gs/β1/γ2
16.67Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
16.67Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
16.67Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
16.67Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
16.67Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
16.67Single8W8XBeta-MSH8W8X-MC3-β-MSH-Ca-Gs/β1/γ2
16.67Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
16.67Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
16.67Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
16.67Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
16.67Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
16.67Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
16.67Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
16.67Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
16.67Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
16.67Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
16.13Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
16.13Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
16.13Single9BYOExendin-39BYO-GLP-1-Exendin-3-Gs/β1/γ2
16.00Single4XT1Fractalkine4XT1-US28-Fractalkine
16.00Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
16.00Single7QA8Peptide7QA8-STE2-Peptide
16.00Single7QA8Peptide7QA8-STE2-Peptide
16.00Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
16.00Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
16.00Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
16.00Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
16.00Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
16.00Single8IEIA1LYA8IEI-GPR156-A1LYA
16.00Single8IEIA1LYA8IEI-GPR156-A1LYA
16.00Single8IEPA1LYA8IEP-GPR156-A1LYA
16.00Single8IEPA1LYA8IEP-GPR156-A1LYA
16.00Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
16.00Single8WDTphotoNECA8WDT-A2A-photoNECA
16.00Single8XWNCXCL88XWN-CXCR2-CXCL8
16.00Single8ZBJSomatostatin-148ZBJ-SST5-Somatostatin-14-Gi1/β1/γ2
16.00Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
16.00Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
16.00Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
16.00Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
15.79Single4MBSMaraviroc4MBS-CCR5-Maraviroc
15.79Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
15.79Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
15.79Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
15.79Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
15.79Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
15.79Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
15.79Single7UTZDPPC7UTZ-TSH-TR1402-DPPC-Gs/β1/γ2
15.79Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
15.79Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
15.79Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
15.79Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
15.79Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
15.79Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
15.79Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
15.79Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
15.79Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
15.79Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
15.79Single9K0XATP9K0X-P2Y2-ATP-chim(NtGi1-Gs-CtGq)/β1/γ2
15.79Single9K20ATP9K20-P2Y2-ATP-chim(NtGi1-Go)/β1/γ2
15.79Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
15.79Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
15.79Consensushca_onOrthosteric Ligandhca2_on
15.79Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
15.62Single7RBTTirzepatide7RBT-GIP-Tirzepatide-LSN3556672-chim(NtGi1-Gs)/β1/γ2
15.62Consensuscrf1_onOrthosteric Ligand6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF1-Corticoliberin-Gs/β1/γ2
15.62Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
15.62Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
15.62Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
15.38Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
15.38Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
15.38Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
15.38Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
15.38Single7XNACYN1548067XNA-SST2-CYN154806
15.38Single8IEBA1LYA8IEB-GPR156-A1LYA
15.38Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
15.38Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
15.38Single9IQVMuscarinic toxin 39IQV-Alpha1A-Muscarinic toxin 3
15.38Single9J0FNADH9J0F-P2Y14-NADH-Gi1/β1/γ2
15.38Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
15.38Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
15.38Consensuspth_on_gpOrthosteric Ligandpth1_on_gp pth2_on_gp
15.38Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
15.15Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
15.15Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
15.15Consensusglp1_onOrthosteric Ligand7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
15.00Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
15.00Single5T04Neurotensin5T04-NTS1-Neurotensin
15.00Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
15.00Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
15.00Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
15.00Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
15.00Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/β1/γ2
15.00Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
15.00Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
15.00Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
15.00Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
15.00Single7V3ZCP559407V3Z-CB1-CP55940
15.00Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
15.00Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
15.00Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.00Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
15.00Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
15.00Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
15.00Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
15.00Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
15.00Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
15.00Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
15.00Single9IZCMK19039IZC-HCA2-MK1903-Gi1/β1/γ2
15.00Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
15.00Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
15.00Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
15.00Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
15.00Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
15.00Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
15.00Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
15.00Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
15.00Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
15.00Consensushca_on_gpOrthosteric Ligandhca2_on_gp
15.00Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
14.81Single3OE0CVX153OE0-CXCR4-CVX15
14.81Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
14.81Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
14.81Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
14.81Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
14.81Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
14.81Single8W8YGamma-MSH8W8Y-MC3-γ-MSH-Ca-Gs/β1/γ2
14.81Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
14.81Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
14.81Single9U4WGonadoliberin-19U4W-GnRH1-Gonadoliberin-1-chim(NtGi1L-Gs-CtGq)/β1/γ2
14.81Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
14.81Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
14.81Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
14.81Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
14.81Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
14.81Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
14.81Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
14.81Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
14.81Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
14.81Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
14.71Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
14.71Consensuscrf1_on_gpOrthosteric Ligand6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF1-Corticoliberin-Gs/β1/γ2
14.71Consensusglp1_on_gpOrthosteric Ligand7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
14.71Consensuspth1_on_gpOrthosteric Ligand6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
14.29Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
14.29Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
14.29Single6JODAngiotensin II6JOD-AT2-Angiotensin II
14.29Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
14.29Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
14.29Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
14.29Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
14.29Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
14.29Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
14.29Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
14.29Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
14.29Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
14.29Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
14.29Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
14.29Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
14.29Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
14.29Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
14.29Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
14.29Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
14.29Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
14.29Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
14.29Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
14.29Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
14.29Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
14.29Single8XYKVUF106618XYK-CXCR3-VUF10661-Go/β1/γ2
14.29Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
14.29Single8ZBISomatostatin-148ZBI-SST3-Somatostatin-14-Gi1/β1/γ2
14.29Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single8ZVZBW245C8ZVZ-DP1-BW245C-Gs/β1/γ2
14.29Single9B9ZA1AKO9B9Z-CB1-A1AKO
14.29Single9CIBFCH-22964139CIB-HCA2-FCH-2296413
14.29Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
14.29Single9EBOGLP-1 (ACPC18)9EBO-GLP-1-GLP-1 (ACPC18)-Gs/β1/γ2
14.29Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
14.29Single9GE2ML1849GE2-GPR55-ML184-chim(NtGi1-G13)/β1/γ2
14.29Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
14.29Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
14.29Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
14.29Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
14.29Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
14.29Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
14.29Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
14.29Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
14.29Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
14.29Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
14.29Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
14.29Consensusep_offOrthosteric Ligandep4_off
14.29Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
14.29Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
14.29Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
14.29Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
14.29Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
14.29Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
14.29Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
14.29Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
14.29Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
13.79Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
13.79Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
13.79Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
13.79Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
13.79Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
13.79Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
13.79Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
13.79Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
13.79Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
13.79Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
13.79Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
13.79Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
13.79Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
13.79Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
13.79Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
13.79Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
13.79Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
13.79Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
13.79Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
13.79Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
13.79Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
13.79Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
13.64Single2YDVNECA2YDV-A2A-NECA
13.64Single4UHRCGS216804UHR-A2A-CGS21680
13.64Single5G53NECA5G53-A2A-NECA-Gs
13.64Single5XR8AM8415XR8-CB1-AM841
13.64Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
13.64Single6J21Aprepitant6J21-NK1-Aprepitant
13.64Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
13.64Single7FEECP559407FEE-CB1-CP55940-ZCZ011
13.64Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
13.64Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
13.64Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
13.64Single7T9NDPPC7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
13.64Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
13.64Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.64Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.64Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
13.64Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
13.64Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
13.64Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
13.64Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
13.64Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
13.64Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
13.64Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
13.64Single8JD5JNJ-40411813; ADX881788JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
13.64Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
13.64Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
13.64Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
13.64Single9CLWTUG-13759CLW-FFA2-TUG-1375-4-CMTB-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.64Single9EGOYVF9EGO-CB1-YVF-Gi1/β1/γ2
13.64Consensusa2_onOrthosteric Liganda2b_on
13.64Consensusa2_on_gpOrthosteric Liganda2b_on_gp
13.64Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
13.64Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
13.64Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
13.64Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
13.64Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
13.64Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
13.64Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
13.64Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
13.64Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
13.64Consensusrelaxin_onOrthosteric Ligandrxfp4_on
13.64Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
13.33Single4XT3Fractalkine4XT3-US28-Fractalkine
13.33Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
13.33Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
13.33Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
13.33Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
13.33Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
13.33Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
13.33Single7SK3CXCL127SK3-ACKR3-CXCL12
13.33Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
13.33Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
13.33Single7XKDBeta-Hydroxyandrosterone7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
13.33Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
13.33Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
13.33Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
13.33Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
13.33Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
13.33Single9BLWCagrilintide backbone (non-acylated)9BLW-CT (AMY1)-Cagrilintide backbone (non-acylated)-Gs/β1/γ2; RAMP1
13.33Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
13.33Single9KFKRelaxin-39KFK-RXFP4-Relaxin-3-Gi2/β1/γ2
13.33Consensuscrf2_on_gpOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
13.33Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
13.33Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
13.33Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
13.16Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
13.16Consensuspth2_on_gpOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
13.04Single4N4WSANT-14N4W-SMO-SANT-1
13.04Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
13.04Single4PY02MeSATP4PY0-P2Y12-2MeSATP
13.04Single5TZYMK8666; AP85TZY-FFA1-MK8666; AP8
13.04Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
13.04Single6IIURamatroban6IIU-TXA2-Ramatroban
13.04Single6KQICP559406KQI-CB1-CP55940-Org27569
13.04Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
13.04Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
13.04Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
13.04Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
13.04Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
13.04Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
13.04Single7K15MKD0467K15-BLT1-MKD046-Na
13.04Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
13.04Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
13.04Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.04Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
13.04Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
13.04Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
13.04Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.04Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
13.04Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
13.04Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
13.04Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
13.04Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
13.04Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
13.04Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
13.04Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
13.04Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
13.04Single8XJNCloprosetnol8XJN-TXA2-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
13.04Single8XQJJN2418XQJ-Apelin-JN241
13.04Single8XWMCXCL68XWM-CXCR2-CXCL6
13.04Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
13.04Single8XYIVUF106618XYI-CXCR3-VUF10661
13.04Single9AU0BW245C9AU0-DP1-BW245C-Gs/β1/γ2
13.04Single9CM3TUG-13759CM3-FFA2-TUG-1375-Compound 187-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.04Single9DGIZ85267113509DGI-CB1-Z8526711350
13.04Single9GGGI-BOP9GGG-TXA2-I-BOP-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.04Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
13.04Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
13.04Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
13.04Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
13.04Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
13.04Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
13.04Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
13.04Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
13.04Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
13.04Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
13.04Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
13.04Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
13.04Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
13.04Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
13.04Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
12.90Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
12.90Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
12.90Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
12.90Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
12.90Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
12.90Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
12.90Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
12.90Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
12.90Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
12.90Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
12.90Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
12.90Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
12.90Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
12.90Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
12.90Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
12.90Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
12.90Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
12.90Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
12.90Consensusglp_onOrthosteric Ligandglp1_on glp2_on
12.90Consensusglp_on_gpOrthosteric Ligandglp1_on_gp glp2_on_gp
12.90Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
12.90Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
12.90Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
12.90Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
12.50Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
12.50Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
12.50Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
12.50Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
12.50Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
12.50Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
12.50Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
12.50Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
12.50Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
12.50Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
12.50Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
12.50Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
12.50Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
12.50Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
12.50Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
12.50Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
12.50Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
12.50Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
12.50Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
12.50Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
12.50Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
12.50Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
12.50Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
12.50Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
12.50Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
12.50Single8IY6Endothelin-18IY6-ETB-Endothelin-1
12.50Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
12.50Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
12.50Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
12.50Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
12.50Single8XJOU466198XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single8XVUCXCL28XVU-CXCR2-CXCL2
12.50Single8XWFCXCL38XWF-CXCR2-CXCL3
12.50Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
12.50Single8ZPLHF511168ZPL-CXCR4-HF51116
12.50Single8ZWGJR14a8ZWG-C3aB-JR14a-Gi1/β1/γ2
12.50Single9BTWCagrilintide9BTW-CT (AMY3)-Cagrilintide-Gs/β1/γ2; RAMP3
12.50Single9C0KExendin-49C0K-GLP-1-Exendin-4-Gs/β1/γ2
12.50Single9GG5U466199GG5-TXA2-U46619-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Single9JH5C16:0 Ceramide9JH5-CysLT2-C16:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single9M1HProstaglandin E29M1H-EP1-Prostaglandin E2-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
12.50Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
12.50Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
12.50Consensusbradykinin_onOrthosteric Ligandbk2_on
12.50Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
12.50Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
12.50Consensuscck_onOrthosteric Ligandccka_on cckb_on
12.50Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
12.50Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
12.50Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
12.50Consensuschemerin_onOrthosteric Ligandcml1_on
12.50Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
12.50Consensusendothelin_onOrthosteric Ligandetb_on eta_on
12.50Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
12.50Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
12.50Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
12.50Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Consensusprostanoid_offOrthosteric Ligandep_off dp_off
12.50Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
12.50Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
12.50Consensuspth1_onOrthosteric Ligand6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
12.50Consensustp_onOrthosteric Ligand8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Consensustp_on_gpOrthosteric Ligand8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Consensusvip-pacap_onOrthosteric Ligandvpac_on pac_on
12.50Consensusvip-pacap_on_gpOrthosteric Ligandvpac_on_gp pac_on_gp
12.12Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
12.12Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
12.12Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
12.00Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
12.00Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
12.00Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
12.00Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
12.00Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
12.00Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
12.00Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
12.00Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
12.00Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
12.00Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
12.00Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
12.00Single7XN9L-054,5227XN9-SST2-L-054,522
12.00Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
12.00Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
12.00Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
12.00Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
12.00Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
12.00Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
12.00Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
12.00Single8XQJJN2418XQJ-Apelin-JN241
12.00Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
12.00Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
12.00Single9CM7TUG-13759CM7-FFA2-TUG-1375-AZ-1729-Gi1/β1/γ2
12.00Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
12.00Single9M0RNeuropeptide VF9M0R-NPFF1-Neuropeptide VF-Gi1/β1/γ2
12.00Single9NS9TUG-13759NS9-FFA2-TUG-1375-Compound 187-Gi1/β1/γ2
12.00Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
12.00Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
12.00Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
12.00Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
12.00Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
11.90Consensusclass-b1_on_gpOrthosteric Ligandglucagon_on_gp vip-pacap_on_gp pth_on_gp crf_on_gp calcitonin_on_gp
11.76Single3OE6IT1t3OE6-CXCR4-IT1t
11.76Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
11.76Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
11.76Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
11.76Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
11.76Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
11.76Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
11.76Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
11.76Single8IW72-Phenylethylamine8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
11.76Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
11.76Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
11.76Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
11.76Single9AUCCalcitonin gene-related peptide-19AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
11.76Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
11.76Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
11.76Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
11.54Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
11.54Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
11.54Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
11.54Single7F8XNN90567F8X-CCKA-NN9056
11.54Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
11.54Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
11.54Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
11.54Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
11.54Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
11.54Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.54Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
11.54Single8IEBA1LYA8IEB-GPR156-A1LYA
11.54Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
11.54Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
11.54Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
11.54Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
11.54Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
11.54Single9BUYLM1899BUY-β2-LM189-Gi1/β1/γ2
11.54Single9HB3Mambaquaretin-19HB3-V2-Mambaquaretin-1
11.54Single9J0IUDP-Glucuronic acid9J0I-P2Y14-UDP-Glucuronic acid-Gi1/β1/γ2
11.54Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
11.54Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
11.54Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
11.54Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
11.54Consensuslpl_onOrthosteric Ligands1p_on lpa_on
11.54Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
11.54Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
11.54Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
11.54Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
11.54Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
11.54Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
11.54Consensussomatostatin_offOrthosteric Ligandsst2_off
11.54Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
11.43Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
11.43Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
11.43Consensuscrf_on_gpOrthosteric Ligandcrf2_on_gp crf1_on_gp
11.11Single3OE9IT1t3OE9-CXCR4-IT1t
11.11Single3QAKUK-4320973QAK-A2A-UK-432097
11.11Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
11.11Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
11.11Single6HLOAprepitant6HLO-NK1-Aprepitant
11.11Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
11.11Single6LI0C176LI0-GPR52-C17
11.11Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
11.11Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
11.11Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
11.11Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
11.11Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
11.11Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
11.11Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
11.11Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
11.11Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
11.11Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
11.11Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
11.11Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
11.11Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
11.11Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
11.11Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
11.11Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
11.11Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
11.11Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
11.11Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
11.11Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
11.11Single8K5BNiacin8K5B-HCA2-Niacin
11.11Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
11.11Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
11.11Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
11.11Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
11.11Single8YKDDehydroepiandrosterone8YKD-ADGRG2-Dehydroepiandrosterone-chim(NtGi1-Gs)/β1/γ2
11.11Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
11.11Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
11.11Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
11.11Single8ZYUNeurotensin peptide 8-138ZYU-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
11.11Single9E7RGB889E7R-PAR2-GB88-chim(NtGi1L-Gs-CtGq)/β1/γ2
11.11Single9E82SDF-1-beta9E82-ACKR3-SDF-1-β-Arrestin2
11.11Single9EPRRetinal9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
11.11Single9IK8SST analogue9IK8-SST1-SST analogue-Gi1/β1/γ2
11.11Single9IQRMuscarinic toxin 39IQR-α2a-Muscarinic toxin 3
11.11Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
11.11Single9IZDCHBA9IZD-HCA1-CHBA-Gi1/β1/γ2
11.11Single9KFIRelaxin-39KFI-RXFP3-Relaxin-3-Gi2/β1/γ2
11.11Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
11.11Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
11.11Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
11.11Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
11.11Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
11.11Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
11.11Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
11.11Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
11.11Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
11.11Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
10.81Consensusglucagon_on_gpOrthosteric Ligandglp_on_gp gluc_on_gp secretin_on_gp gip_on_gp
10.81Consensuspth_onOrthosteric Ligandpth1_on pth2_on
10.71Single5WF5UK-4320975WF5-A2A-UK-432097
10.71Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
10.71Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
10.71Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
10.71Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
10.71Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
10.71Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.71Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
10.71Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
10.71Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
10.71Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
10.71Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
10.71Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
10.71Single9M1OMorphine-Modulating Neuropeptide B9M1O-NPFF2-Morphine-Modulating Neuropeptide B-Gi1/β1/γ2
10.71Consensusangiotensin_onOrthosteric Ligandat1_on
10.71Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
10.71Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
10.71Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
10.71Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
10.71Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
10.71Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
10.53Single3ODUIT1t3ODU-CXCR4-IT1t
10.53Single3PWHZM-2413853PWH-A2A-ZM-241385
10.53Single4BWBNeurotensin4BWB-NTS1-Neurotensin
10.53Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
10.53Single6AKXA4R6AKX-CCR5-A4R
10.53Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
10.53Single6ME2Ramelteon6ME2-MT1-Ramelteon
10.53Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
10.53Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
10.53Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
10.53Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
10.53Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
10.53Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
10.53Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
10.53Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.53Single8GNGIstradefylline8GNG-A2A-Istradefylline
10.53Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
10.53Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
10.53Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
10.53Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
10.53Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
10.53Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
10.53Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
10.53Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
10.53Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
10.53Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
10.53Single8YYWAlpha-ketoglutarate8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
10.53Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
10.53Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
10.53Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
10.53Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
10.53Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
10.53Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
10.53Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
10.53Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
10.53Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
10.34Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
10.34Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
10.34Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
10.34Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
10.34Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
10.34Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
10.34Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
10.34Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
10.34Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
10.34Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
10.34Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
10.34Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ2
10.34Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
10.34Single9BLCCagrilintide backbone (non-acylated)9BLC-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
10.34Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
10.34Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
10.34Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
10.34Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
10.34Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
10.34Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
10.34Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
10.34Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
10.34Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
10.34Consensusvasop-oxy_onOrthosteric Ligandv2_on
10.34Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
10.00Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
10.00Single2YDOAdenosine2YDO-A2A-Adenosine
10.00Single6FFIMMPEP6FFI-mGlu5-MMPEP
10.00Single6KUXRS-799486KUX-α2a-RS-79948
10.00Single6MH8ZM-2413856MH8-A2A-ZM-241385
10.00Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
10.00Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
10.00Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
10.00Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
10.00Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
10.00Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
10.00Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
10.00Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
10.00Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
10.00Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
10.00Single7F61PF-036547467F61-H3-PF-03654746
10.00Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Single7T94LY21196207T94-M2-Acetylcholine-LY2119620-chim(NtGi1-Go)/β1/γ2
10.00Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
10.00Single7UL3Famotidine7UL3-H2-Famotidine
10.00Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
10.00Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
10.00Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
10.00Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
10.00Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
10.00Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.00Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
10.00Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
10.00Single8IHKAcifran8IHK-HCA3-Acifran
10.00Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
10.00Single8JD6VU03647708JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
10.00Single8K5CAcipimox8K5C-HCA2-Acipimox
10.00Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
10.00Single8K9LDamgo8K9L-μ-Damgo-BMS-986122-Gi3/β1/γ1
10.00Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
10.00Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
10.00Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
10.00Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
10.00Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
10.00Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
10.00Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
10.00Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
10.00Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
10.00Single8ZPMAMD0708ZPM-CXCR4-AMD070
10.00Single8ZRTET-18ZRT-ETB-ET-1
10.00Single9JMDAzithromycin9JMD-Motilin-Azithromycin-chim(Gs-CtGq)/β1/γ2
10.00Single9K0KUTP9K0K-P2Y4-UTP-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Gi1/β1/γ2
10.00Single9M2FNeuropeptide FF9M2F-NPFF1-Neuropeptide FF-Gi1/β1/γ2
10.00Consensuscalcitonin_onOrthosteric Ligandctlike_on
10.00Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
10.00Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
10.00Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
10.00Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
10.00Consensuspac_onOrthosteric Ligandpac1_on
10.00Consensusvpac_onOrthosteric Ligandvpac1_on vpac2_on
9.68Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
9.68Single9BLBCagrilintide backbone (non-acylated)9BLB-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
9.68Single9BP3Cagrilintide9BP3-CT (AMY1)-Cagrilintide-Gs/β1/γ2; RAMP1
9.68Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
9.68Consensuscalcitonin_on_gpOrthosteric Ligandctlike_on_gp
9.68Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
9.68Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
9.68Consensuspac_on_gpOrthosteric Ligandpac1_on_gp
9.68Consensusvpac_on_gpOrthosteric Ligandvpac1_on_gp vpac2_on_gp
9.52Single2Y02Carmoterol2Y02-β1-Carmoterol
9.52Single4QIMANTA XV4QIM-SMO-ANTA XV
9.52Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
9.52Single4YAYZD-71554YAY-AT1-ZD-7155
9.52Single5TGZAM65385TGZ-CB1-AM6538
9.52Single6FFHFenobam6FFH-mGlu5-Fenobam
9.52Single6TOTLemborexant6TOT-OX1-Lemborexant
9.52Single6XBM5LWE6XBM-SMO-5LWE-Gi1/β1/γ2
9.52Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
9.52Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
9.52Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
9.52Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
9.52Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
9.52Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
9.52Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
9.52Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
9.52Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
9.52Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
9.52Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
9.52Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
9.52Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
9.52Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
9.52Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
9.52Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
9.52Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
9.52Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
9.52Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
9.52Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
9.52Single8K5DGSK2560738K5D-HCA2-GSK256073
9.52Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
9.52Single8PJKST1718PJK-5-HT1A-ST171-Gi1/β1/γ1
9.52Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
9.52Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
9.52Single8T1WCVN4248T1W-GPR6-CVN424
9.52Single8TH3AT118-H Nanobody8TH3-AT1-AT118-H Nanobody
9.52Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
9.52Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
9.52Single8X64Desloratadine8X64-H1-Desloratadine
9.52Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
9.52Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
9.52Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
9.52Single9CHXS-Carazolol9CHX-β2-S-Carazolol
9.52Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
9.52Single9IMATalquetamab9IMA-GPRC5D-Talquetamab
9.52Single9IVGGLP-1 (Truncated)9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
9.52Single9IYAONO-97105319IYA-GPR55-ONO-9710531
9.52Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
9.52Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
9.52Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
9.52Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
9.52Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
9.52Consensusblt_onOrthosteric Ligandblt1_on
9.52Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
9.52Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
9.52Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
9.52Consensusleukotriene_onOrthosteric Ligandblt_on
9.52Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
9.52Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
9.38Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
9.38Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
9.38Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
9.38Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
9.38Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
9.38Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
9.38Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
9.38Single8W8WAlpha-MSH8W8W-MC3-α-MSH-Ca-Gs/β1/γ2
9.38Single9BUCCagrilintide9BUC-CT-Cagrilintide-Gs/β1/γ2
9.38Single9KDFRES-701-39KDF-ETB-RES-701-3
9.38Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
9.38Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
9.09Single4JKVTaladegib4JKV-SMO-Taladegib
9.09Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
9.09Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
9.09Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
9.09Single6D26Fevipiprant6D26-DP2-Fevipiprant
9.09Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
9.09Single6IGLIRL16206IGL-ETB-IRL1620
9.09Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
9.09Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
9.09Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
9.09Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
9.09Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
9.09Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
9.09Single6TP6Filorexant6TP6-OX1-Filorexant
9.09Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
9.09Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
9.09Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
9.09Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
9.09Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
9.09Single7LD3Adenosine7LD3-A1-Adenosine-MIPS521-Gi2/β1/γ2
9.09Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
9.09Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
9.09Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
9.09Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
9.09Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
9.09Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
9.09Single7W41PD1762527W41-BB2-PD176252
9.09Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
9.09Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
9.09Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.09Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
9.09Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
9.09Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
9.09Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
9.09Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
9.09Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
9.09Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
9.09Single8JXSPF-61428JXS-D1-PF-6142
9.09Single8QOTNanobody-E8QOT-μ-Nanobody-E
9.09Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
9.09Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
9.09Single8TF5Oleic acid8TF5-GPR6-Oleic acid
9.09Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
9.09Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
9.09Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
9.09Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
9.09Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
9.09Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
9.09Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
9.09Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
9.09Single8ZMFA1L108ZMF-5-HT2C-A1L10
9.09Single8ZYTNeurotensin peptide 8-138ZYT-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
9.09Single9BQ3Cagrilintide9BQ3-CT (AMY2)-Cagrilintide-Gs/β1/γ2; RAMP2
9.09Single9DYDAsenapine9DYD-5-HT1A-Asenapine-Go/β1/γ2
9.09Single9DYFAsenapine9DYF-5-HT1A-Asenapine-Gi1/β1/γ2
9.09Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
9.09Single9EE8Adenosine9EE8-A2A-Adenosine-Gs/β1/γ2
9.09Single9EHSLUF76029EHS-A3A-LUF7602
9.09Single9F33FOB02-04A9F33-D3-FOB02-04A-Go/β1/γ2
9.09Single9I52A1IZU9I52-D1-A1IZU-Gs/β1/γ2
9.09Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
9.09Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
9.09Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
9.09Consensusbombesin_offOrthosteric Ligandbb2_off
9.09Consensusctlike_on_gpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
9.09Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
9.09Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
9.09Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
9.09Consensusdp_offOrthosteric Liganddp2_off
9.09Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
9.09Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
9.09Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
9.09Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
9.09Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
9.09Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
9.09Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
9.09Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
9.09Consensustrace-amine_onOrthosteric Ligandta1_on
8.82Single5GLHEndothelin-15GLH-ETB-Endothelin-1
8.82Single6IGKEndothelin-36IGK-ETB-Endothelin-3
8.82Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
8.82Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
8.70Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
8.70Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
8.70Single4BV0Neurotensin4BV0-NTS1-Neurotensin
8.70Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
8.70Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
8.70Single4U15Tiotropium4U15-M3-Tiotropium
8.70Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
8.70Single5TZRMK86665TZR-FFA1-MK8666
8.70Single5V54Methiothepin5V54-5-HT1B-Methiothepin
8.70Single5V56TC1145V56-SMO-TC114
8.70Single5V57TC1145V57-SMO-TC114
8.70Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
8.70Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
8.70Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
8.70Single6OL9Tiotropium6OL9-M5-Tiotropium
8.70Single6OS1TRV0266OS1-AT1-TRV026
8.70Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
8.70Single6WGTLSD6WGT-5-HT2A-LSD
8.70Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
8.70Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
8.70Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
8.70Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
8.70Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
8.70Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
8.70Single7F1TMIP-1a7F1T-CCR5-MIP-1a
8.70Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
8.70Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
8.70Single7P2L4YI7P2L-mGlu5-4YI
8.70Single7PX4PSB-21137PX4-A2A-PSB-2113
8.70Single7R0CAVP7R0C-V2-AVP-Arrestin2
8.70Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
8.70Single7TUYGSK682753A7TUY-GPR183-GSK682753A
8.70Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
8.70Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
8.70Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
8.70Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
8.70Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
8.70Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
8.70Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
8.70Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
8.70Single8EA0Iperoxo8EA0-M3-Iperoxo
8.70Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
8.70Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.70Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
8.70Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
8.70Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
8.70Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
8.70Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
8.70Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
8.70Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
8.70Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
8.70Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
8.70Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
8.70Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
8.70Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
8.70Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
8.70Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
8.70Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
8.70Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
8.70Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
8.70Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
8.70Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
8.70Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Gi1/β1/γ1
8.70Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
8.70Single8Y73Peptide8Y73-μ-Peptide-MPAM-15-Gi1/β1/γ2
8.70Single8ZW0PGD28ZW0-DP1-PGD2-Gs/β1/γ2
8.70Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
8.70Single9I54A1IZV9I54-D1-A1IZV-Gs/β1/γ2
8.70Single9IK9SST analogue9IK9-SST1-SST analogue-Gi1/β1/γ2
8.70Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
8.70Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
8.70Consensus5ht1_offOrthosteric Ligand5ht1b_off
8.70Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
8.70Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
8.70Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
8.70Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
8.70Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
8.70Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
8.70Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
8.70Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
8.70Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
8.70Consensuslpa_onOrthosteric Ligandlpa1_on
8.70Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
8.70Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
8.70Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
8.70Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
8.70Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
8.70Consensusneurotensin_onOrthosteric Ligandnts1_on
8.70Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
8.70Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
8.70Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
8.70Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
8.70Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
8.70Consensustachykinin_offOrthosteric Ligandnk1_off
8.70Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
8.57Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
8.57Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
8.57Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
8.57Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
8.57Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
8.33Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
8.33Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
8.33Single4AMIBucindolol4AMI-β1-Bucindolol
8.33Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
8.33Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
8.33Single4RWADIPP-NH24RWA-δ-DIPP-NH2
8.33Single4XEENeurotensin4XEE-NTS1-Neurotensin
8.33Single4XESNeurotensin4XES-NTS1-Neurotensin
8.33Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
8.33Single5CXVTiotropium5CXV-M1-Tiotropium
8.33Single6A93Risperidone6A93-5-HT2A-Risperidone
8.33Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
8.33Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
8.33Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
8.33Single6MXTSalmeterol6MXT-β2-Salmeterol
8.33Single6OS2TRV0266OS2-AT1-TRV026
8.33Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
8.33Single6YVRNTS8-136YVR-NTS1-NTS8-13
8.33Single7DFPSpiperone7DFP-D2-Spiperone
8.33Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
8.33Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
8.33Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
8.33Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
8.33Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
8.33Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
8.33Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
8.33Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
8.33Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
8.33Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
8.33Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
8.33Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
8.33Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
8.33Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
8.33Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
8.33Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
8.33Single8JD3JNJ-404118138JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
8.33Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
8.33Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
8.33Single8JJLOlodaterol8JJL-β2-Olodaterol
8.33Single8JWY2-1188JWY-A2A-2-118
8.33Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.33Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
8.33Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
8.33Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
8.33Single9BJKNAM9BJK-μ-Naloxone-NAM
8.33Single9EBIPiclidenoson9EBI-A3A-Piclidenoson-chim(NtGi1L-Gs-CtGi1)/β1/γ2
8.33Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
8.33Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
8.33Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
8.33Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
8.33Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
8.33Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
8.33Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
8.33Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
8.33Consensusalpha1_offOrthosteric Ligandalpha1a_off
8.33Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
8.33Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
8.33Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
8.33Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
8.33Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
8.33Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
8.33Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
8.33Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
8.33Consensuslpa_offOrthosteric Ligandlpa1_off
8.33Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
8.33Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
8.33Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
8.33Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
8.33Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
8.33Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
8.33Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
8.11Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
8.11Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
8.11Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
8.11Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
8.11Consensusclass-a_class-b1_cons_on_gpOrthosteric Ligandclass-a_on_gp class-b1_on_gp
8.11Consensusglucagon_onOrthosteric Ligandglp_on gluc_on secretin_on gip_on
8.00Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
8.00Single4BUONeurotensin4BUO-NTS1-Neurotensin
8.00Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
8.00Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
8.00Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
8.00Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
8.00Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
8.00Single6IBLArformoterol6IBL-β1-Arformoterol
8.00Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
8.00Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
8.00Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
8.00Single7EZCUKA7EZC-A2A-UKA
8.00Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
8.00Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
8.00Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
8.00Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
8.00Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
8.00Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
8.00Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
8.00Single7UM4AS26747237UM4-5-HT5A-AS2674723
8.00Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
8.00Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
8.00Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
8.00Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
8.00Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
8.00Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
8.00Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
8.00Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
8.00Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.00Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
8.00Single8JPFNeurotensin8JPF-NTS1-Neurotensin-SBI-553
8.00Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
8.00Single8T3OTUG-8918T3O-FFA4-TUG-891-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.00Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
8.00Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
8.00Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
8.00Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
8.00Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
8.00Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
8.00Single9M54Neuropeptide VF9M54-NPFF2-Neuropeptide VF-Gi1/β1/γ2
8.00Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
8.00Consensusfp-alpha_onOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
8.00Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
8.00Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
8.00Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
7.89Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
7.69Single3NY9ICI118-5513NY9-β2-ICI118-551
7.69Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
7.69Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
7.69Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
7.69Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
7.69Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
7.69Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
7.69Single8X5YAstemizole8X5Y-H1-Astemizole
7.69Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
7.69Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
7.69Single8Y72Peptide8Y72-μ-Peptide-BMS-986122-Gi1/β1/γ2
7.69Single9IPVJR14a9IPV-C3aB-JR14a-Gi1/β1/γ2
7.69Single9IPYJR14a9IPY-C3aB-JR14a
7.69Single9IZASCH9002719IZA-HCA2-SCH900271-Gi1/β1/γ2
7.69Single9JF4PD1683689JF4-BB1-PD168368
7.69Single9JH6C20:0 Ceramide9JH6-CysLT2-C20:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Single9V2NMacimorelin9V2N-Ghrelin-Macimorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Consensusclass-b2_onOrthosteric Ligandadgrg_on adgrf_on adgrl_on adgre_on adgrd_on
7.69Consensusclass-b2_on_gpOrthosteric Ligandadgrg_on_gp adgrf_on_gp adgrl_on_gp adgre_on_gp adgrd_on_gp
7.69Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
7.69Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
7.69Consensuskisspeptin_onOrthosteric Ligandkiss1_on
7.69Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
7.50Consensusclass-b1_onOrthosteric Ligandglucagon_on vip-pacap_on pth_on crf_on calcitonin_on
7.41Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
7.41Single4IARErgotamine4IAR-5-HT1B-Ergotamine
7.41Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
7.41Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
7.41Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
7.41Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
7.41Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
7.41Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
7.41Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
7.41Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
7.41Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
7.41Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
7.41Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
7.41Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
7.41Single8KIGSHU91198KIG-MC3-SHU9119-Ca
7.41Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
7.41Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
7.41Single8YWFRetatrutide8YWF-GLP-1-Retatrutide-chim(NtGi1-Gs)/β1/γ2
7.41Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
7.41Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
7.41Single9BUECagrilintide9BUE-CT-Cagrilintide-Gs/β1/γ2
7.41Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
7.41Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
7.41Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
7.41Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
7.41Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
7.41Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
7.41Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
7.32Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
7.14Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
7.14Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
7.14Single7SK5CXCL127SK5-ACKR3-CXCL12
7.14Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
7.14Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
7.14Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
7.14Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
7.14Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
7.14Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
7.14Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
7.14Single9IQSMuscarinic toxin 39IQS-M4-Muscarinic toxin 3
7.14Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
7.14Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
7.14Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
7.14Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
7.14Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
6.90Single6W25SHU91196W25-MC4-SHU9119-Ca
6.90Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
6.90Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
6.90Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
6.90Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
6.90Single9B5YLong-Acting PTH9B5Y-PTH1-Long-Acting PTH-chim(NtGi1-Gq)/β1/γ2
6.90Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
6.90Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
6.90Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
6.90Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
6.90Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
6.67Single4A4MAll-trans-Retinal4A4M-Rhodopsin-All-trans-Retinal-Gt(CT)
6.67Single5EN0All-trans-Retinal5EN0-Rhodopsin-All-trans-Retinal-Gt(CT)
6.67Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
6.67Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
6.67Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
6.67Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
6.67Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
6.67Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/β1/γ2
6.67Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
6.67Single9BUDCagrilintide9BUD-CT-Cagrilintide-Gs/β1/γ2
6.67Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
6.67Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
6.45Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
6.45Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
6.45Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
6.45Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
6.45Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
6.45Single9JFYhNPSF9JFY-NPFF2-hNPSF-Gi1/β1/γ2
6.45Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
6.45Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
6.25Single3PXOAll-trans-Retinal3PXO-Rhodopsin-All-trans-Retinal
6.25Single5DYSAll-trans-Retinal5DYS-Rhodopsin-All-trans-Retinal
6.25Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
6.25Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
6.25Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
6.25Single7V68LY21196207V68-M4-Iperoxo-LY2119620-Gi1/β1/γ2
6.25Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
6.25Single7WC4Serotonin7WC4-5-HT2A-Serotonin
6.25Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
6.25Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
6.25Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
6.25Single8PWNTheophylline8PWN-A2A-Theophylline
6.25Single9BUBCagrilintide9BUB-CT-Cagrilintide-Gs/β1/γ2
6.25Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
6.25Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
6.25Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
6.25Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
6.06Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
6.06Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
5.88Single6OY9All-trans-Retinal6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
5.88Single6TQ9SB-4081246TQ9-OX1-SB-408124
5.88Single6XBM5LWE6XBM-SMO-5LWE-Gi1/β1/γ2
5.88Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
5.88Single8A2OTheophylline8A2O-A2A-Theophylline-Na
5.88Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
5.88Single8IWM2-Phenylethylamine8IWM-TA9-2-Phenylethylamine
5.88Single8Y02Retinal8Y02-OPN1SW-Retinal-Gi1/β1/γ2
5.88Single9IVMLSN33188399IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
5.88Consensusgs_histamineOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
5.88Consensush2_onOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
5.88Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
5.88Consensusp2y_offOrthosteric Ligandp2y1_off
5.88Consensussensory_onOrthosteric Ligandopsins_on
5.71Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
5.71Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
5.71Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
5.71Consensusbombesin_onOrthosteric Ligandbb2_on
5.71Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
5.71Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
5.71Consensusclass-a_class-b1_cons_onOrthosteric Ligandclass-a_on class-b1_on
5.71Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
5.56Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
5.56Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
5.56Single3PQRAll-trans-Retinal3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
5.56Single4XNWMRS25004XNW-P2Y1-MRS2500
5.56Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
5.56Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
5.56Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
5.56Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
5.56Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
5.56Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/β1/γ2
5.56Single7WC5Psilocin7WC5-5-HT2A-Psilocin
5.56Single7Y12Beta-Alanine7Y12-MRGPRD-β-Alanine-Gi1/β1/γ2
5.56Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.56Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
5.56Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.56Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
5.56Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
5.56Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
5.56Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
5.56Single8J6QCompound 9n8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
5.56Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
5.56Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
5.56Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
5.56Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
5.56Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
5.56Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
5.56Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
5.56Single9LRCHistamine9LRC-H4-Histamine
5.56Single9LREHistamine9LRE-H4-Histamine-Gi1/β1/γ2
5.56Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
5.56Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
5.56Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
5.56Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
5.56Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
5.56Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
5.56Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
5.56Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
5.56Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
5.26Single3PBLEticlopride3PBL-D3-Eticlopride
5.26Single4O9RCyclopamine4O9R-SMO-Cyclopamine
5.26Single5L7IVismodegib5L7I-SMO-Vismodegib
5.26Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
5.26Single6HLLCP999946HLL-NK1-CP99994
5.26Single6TP4ACT-4622066TP4-OX1-ACT-462206
5.26Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
5.26Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
5.26Single7V68Iperoxo7V68-M4-Iperoxo-LY2119620-Gi1/β1/γ2
5.26Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
5.26Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
5.26Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
5.26Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
5.26Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
5.26Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
5.26Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
5.26Single8HSCFab0468HSC-GPR20-Fab046-Gi1/β1/γ2
5.26Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
5.26Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
5.26Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/β1/γ2
5.26Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
5.26Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
5.26Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
5.26Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
5.26Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
5.26Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.26Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
5.26Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
5.26Single8YN7Immethridine8YN7-H3-Immethridine-Go/β1/γ2
5.26Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
5.26Single9B9Y7DY9B9Y-CB1-7DY
5.26Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
5.26Single9IXJHistamine9IXJ-H2-Histamine-Gs/β1/γ2
5.26Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
5.26Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
5.00Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
5.00Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
5.00Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
5.00Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
5.00Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
5.00Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
5.00Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
5.00Single4K5YCP-3763954K5Y-CRF1-CP-376395
5.00Single4QINSAG1.54QIN-SMO-SAG1.5
5.00Single4S0VSuvorexant4S0V-OX2-Suvorexant
5.00Single4XNVBPTU4XNV-P2Y1-BPTU
5.00Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
5.00Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
5.00Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
5.00Single5WS3EMPA5WS3-OX2-EMPA
5.00Single6B73MP11046B73-κ-MP1104
5.00Single6C1QNDT95137276C1Q-C5a1-PMX53-NDT9513727
5.00Single6DS0Ly2660976DS0-5-HT2B-Ly266097
5.00Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
5.00Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
5.00Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
5.00Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
5.00Single6TODEMPA6TOD-OX1-EMPA-Na
5.00Single6TPJSuvorexant6TPJ-OX2-Suvorexant
5.00Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
5.00Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
5.00Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
5.00Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
5.00Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
5.00Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
5.00Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
5.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
5.00Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
5.00Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
5.00Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
5.00Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
5.00Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
5.00Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
5.00Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
5.00Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
5.00Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
5.00Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
5.00Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
5.00Single7XRRLemborexant7XRR-OX2-Lemborexant
5.00Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
5.00Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
5.00Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
5.00Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
5.00Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.00Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.00Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
5.00Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
5.00Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
5.00Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
5.00Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
5.00Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
5.00Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
5.00Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
5.00Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
5.00Single8IWESpermidine8IWE-TA9-Spermidine
5.00Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
5.00Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
5.00Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
5.00Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.00Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
5.00Single8U4PAMD31008U4P-CXCR4-AMD3100-Gi1/β1/γ2
5.00Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.00Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.00Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
5.00Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
5.00Single8Y0HVUF114188Y0H-CXCR3-VUF11418
5.00Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go/β1/γ2
5.00Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ2
5.00Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
5.00Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
5.00Single8YYWAlpha-ketoglutarate8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
5.00Single9EBHAdenosine9EBH-A3A-Adenosine-Gi1/β1/γ2
5.00Single9EEAAdenosine9EEA-A2A-Adenosine-Gs/β1/γ2
5.00Single9H2XA1IR19H2X-A2A-A1IR1-Na
5.00Single9KPESA09KPE-TAS2R16-SA0-Gi1/β1/γ2
5.00Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
5.00Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
5.00Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
5.00Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
5.00Consensusangiotensin_offOrthosteric Ligandat1_off
5.00Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
5.00Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
5.00Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
5.00Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
5.00Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
5.00Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
5.00Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
5.00Consensusorexin_offOrthosteric Ligandox2_off ox1_off
5.00Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
5.00Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
5.00Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
5.00Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
4.76Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
4.76Single3REYXAC3REY-A2A-XAC
4.76Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
4.76Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
4.76Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
4.76Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
4.76Single4ZJCSB-6740424ZJC-OX1-SB-674042
4.76Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
4.76Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
4.76Single5IU7Q274563465IU7-A2A-Q27456346-Na
4.76Single5IUBQ274563445IUB-A2A-Q27456344-Na
4.76Single5JTBZM-2413855JTB-A2A-ZM-241385
4.76Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
4.76Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
4.76Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
4.76Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
4.76Single5UVIZM-2413855UVI-A2A-ZM-241385
4.76Single6A94Zotepine6A94-5-HT2A-Zotepine
4.76Single6AQFZM-2413856AQF-A2A-ZM-241385
4.76Single6PS0S-Carazolol6PS0-β2-S-Carazolol
4.76Single6PS4ICI118-5516PS4-β2-ICI118-551
4.76Single6PS5S-Propranolol6PS5-β2-S-Propranolol
4.76Single6TP3Nemorexant6TP3-OX1-Nemorexant
4.76Single6TPGEMPA6TPG-OX2-EMPA
4.76Single6TPNHTL66416TPN-OX2-HTL6641
4.76Single6VI4JDTic6VI4-κ-JDTic
4.76Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
4.76Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
4.76Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
4.76Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
4.76Single7AROLUF58337ARO-A2A-LUF5833-Na
4.76Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
4.76Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
4.76Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
4.76Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
4.76Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
4.76Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
4.76Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
4.76Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
4.76Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.76Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
4.76Single7T32ZM-2413857T32-A2A-ZM-241385
4.76Single7T94Acetylcholine7T94-M2-Acetylcholine-LY2119620-chim(NtGi1-Go)/β1/γ2
4.76Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
4.76Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
4.76Single7VODCariprazine7VOD-5-HT2A-Cariprazine
4.76Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
4.76Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
4.76Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
4.76Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
4.76Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
4.76Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
4.76Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.76Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
4.76Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
4.76Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
4.76Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
4.76Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
4.76Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
4.76Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
4.76Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
4.76Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
4.76Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.76Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.76Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.76Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
4.76Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
4.76Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
4.76Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
4.76Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
4.76Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
4.76Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
4.76Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
4.76Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
4.76Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
4.76Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
4.76Single8K2WAMG4878K2W-CXCR3-AMG487
4.76Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
4.76Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
4.76Single8RLNLUF58348RLN-A2A-LUF5834
4.76Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
4.76Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
4.76Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
4.76Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.76Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.76Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
4.76Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
4.76Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.76Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.76Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.76Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.76Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.76Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
4.76Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
4.76Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.76Single8Y6YGLPG09748Y6Y-FFA2-GLPG0974
4.76Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
4.76Single8YRGFospropofol8YRG-MRGPRX4-Fospropofol-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
4.76Single9ARXSerotonin9ARX-5-HT2A-Serotonin
4.76Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
4.76Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Single9BA0A1AKN9BA0-CB1-A1AKN
4.76Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
4.76Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Single9IXXLTD49IXX-CysLT2-LTD4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Single9JH3CMF-0199JH3-Apelin-CMF-019-Gi1/β1/γ2
4.76Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
4.76Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
4.76Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
4.76Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
4.76Consensusa2_offOrthosteric Liganda2a_off
4.76Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
4.76Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
4.76Consensusalpha1_onOrthosteric Ligandalpha1a_on
4.76Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
4.76Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
4.76Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
4.76Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
4.76Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
4.76Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
4.76Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
4.76Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
4.76Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
4.76Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
4.76Consensusopsins_offOrthosteric Ligandrhodopsin_off
4.76Consensussensory_offOrthosteric Ligandopsins_off
4.55Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
4.55Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
4.55Single2Y01Dobutamine2Y01-β1-Dobutamine
4.55Single2Y04Salbutamol2Y04-β1-Salbutamol
4.55Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
4.55Single3EMLZM-2413853EML-A2A-ZM-241385
4.55Single3NY8ICI118-5513NY8-β2-ICI118-551
4.55Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
4.55Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
4.55Single4DAJTiotropium4DAJ-M3-Tiotropium
4.55Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
4.55Single4EJ4Naltrindole4EJ4-δ-Naltrindole
4.55Single4GBRS-Carazolol4GBR-β2-S-Carazolol
4.55Single4MQSIperoxo4MQS-M2-Iperoxo
4.55Single4QKX35V4QKX-β2-35V
4.55Single4U14Tiotropium4U14-M3-Tiotropium
4.55Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
4.55Single4Z9GCP-3763954Z9G-CRF1-CP-376395
4.55Single5DSGTiotropium5DSG-M4-Tiotropium
4.55Single5IU8Q274563475IU8-A2A-Q27456347-Na
4.55Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
4.55Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
4.55Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
4.55Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
4.55Single5UENDU1725UEN-A1-DU172
4.55Single5UIGCmpd-15UIG-A2A-Cmpd-1
4.55Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
4.55Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
4.55Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
4.55Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
4.55Single6D27CAY104716D27-DP2-CAY10471
4.55Single6DRXLisuride6DRX-5-HT2B-Lisuride
4.55Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
4.55Single6H7MSalbutamol6H7M-β1-Salbutamol
4.55Single6IIVDaltroban6IIV-TXA2-Daltroban
4.55Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
4.55Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
4.55Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
4.55Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
4.55Single6S0LZM-2413856S0L-A2A-ZM-241385
4.55Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.55Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
4.55Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
4.55Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
4.55Single7BU7BI1671077BU7-β1-BI167107
4.55Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
4.55Single7F83PF-051904577F83-Ghrelin-PF-05190457
4.55Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
4.55Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
4.55Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
4.55Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
4.55Single7PYRPSB-21157PYR-A2A-PSB-2115
4.55Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
4.55Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
4.55Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
4.55Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
4.55Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
4.55Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
4.55Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
4.55Single7UL4Alvimopan7UL4-μ-Alvimopan
4.55Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
4.55Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
4.55Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
4.55Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
4.55Single7WC7Lisuride7WC7-5-HT2A-Lisuride
4.55Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
4.55Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
4.55Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
4.55Single8CU6LJ-45178CU6-A2A-LJ-4517
4.55Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
4.55Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
4.55Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
4.55Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
4.55Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
4.55Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
4.55Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
4.55Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.55Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.55Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.55Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.55Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.55Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.55Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.55Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.55Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.55Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.55Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
4.55Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
4.55Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
4.55Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
4.55Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
4.55Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
4.55Single8GTIBMK-C2058GTI-CRF1-BMK-C205
4.55Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
4.55Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
4.55Single8JXRLSD8JXR-D1-LSD
4.55Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
4.55Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.55Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.55Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.55Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.55Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.55Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.55Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.55Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
4.55Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
4.55Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
4.55Single8X63Mepyramine8X63-H1-Mepyramine
4.55Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
4.55Single8YN8Proxyfan8YN8-H3-Proxyfan-Go/β1/γ2
4.55Single8ZYYNeurotensin peptide 8-138ZYY-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
4.55Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
4.55Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
4.55Single9H37A1IR09H37-A2A-A1IR0-Na
4.55Single9JEAAtropine9JEA-M1-Atropine
4.55Single9JGKBalovaptan9JGK-5-HT2B-Balovaptan
4.55Single9KFJPubChem 1383196749KFJ-RXFP3-PubChem 138319674-Gi2/β1/γ2
4.55Single9PLNN-(5-methylnaphthalen-1-yl)pyridin-4-amine9PLN-α2a-N-(5-methylnaphthalen-1-yl)pyridin-4-amine
4.55Single9PLON-(5-methylnaphthalen-1-yl)pyridin-4-amine9PLO-α2a-N-(5-methylnaphthalen-1-yl)pyridin-4-amine-Go/β1/γ2
4.55Single9PQD(6m)-1-methyl-6-(1,2,5,6-tetrahydropyridin-3-yl)-1h-indole9PQD-α2a-(6m)-1-methyl-6-(1,2,5,6-tetrahydropyridin-3-yl)-1h-indole
4.55Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
4.55Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
4.55Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
4.55Consensus5ht5_onOrthosteric Ligand5ht5a_on
4.55Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
4.55Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
4.55Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
4.55Consensusa3_onOrthosteric Liganda3a_on
4.55Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
4.55Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
4.55Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
4.55Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
4.55Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
4.55Consensusdopamine_offOrthosteric Ligandd2_off d3_off
4.55Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
4.55Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
4.55Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
4.55Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
4.55Consensushistamine_offOrthosteric Ligandh1_off
4.55Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
4.55Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
4.55Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
4.55Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
4.55Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
4.35Single2RH1S-Carazolol2RH1-β2-S-Carazolol
4.35Single2Y00Dobutamine2Y00-β1-Dobutamine
4.35Single2Y03Isoprenaline2Y03-β1-Isoprenaline
4.35Single2YCWS-Carazolol2YCW-β1-S-Carazolol
4.35Single4NTJAZD12834NTJ-P2Y12-AZD1283
4.35Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
4.35Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
4.35Single5C1MBU725C1M-μ-BU72
4.35Single5D6LS-Carazolol5D6L-β2-S-Carazolol
4.35Single5IUAQ274563485IUA-A2A-Q27456348-Na
4.35Single5JQHS-Carazolol5JQH-β2-S-Carazolol
4.35Single5N2RPSB-365N2R-A2A-PSB-36-Na
4.35Single5N2SPSB365N2S-A1-PSB36
4.35Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
4.35Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
4.35Single5T1ABMS-6815T1A-CCR2-BMS-681-PubChem 12093170
4.35Single5TVNLSD5TVN-5-HT2B-LSD
4.35Single5WIUNemonapride5WIU-D4-Nemonapride
4.35Single5WIVNemonapride5WIV-D4-Nemonapride-Na
4.35Single5WQCEMPA5WQC-OX2-EMPA
4.35Single5X7DS-Carazolol5X7D-β2-S-Carazolol-Cmpd-15
4.35Single5XPRBosentan5XPR-ETB-Bosentan
4.35Single6E67BI1671076E67-β2-BI167107-Gs(CT)
4.35Single6HLPNetupitant6HLP-NK1-Netupitant
4.35Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
4.35Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
4.35Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
4.35Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
4.35Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
4.35Single6S0QZM-2413856S0Q-A2A-ZM-241385
4.35Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
4.35Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
4.35Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
4.35Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
4.35Single7C4SS1P7C4S-S1P3-S1P
4.35Single7C61Ergotamine7C61-5-HT1B-Ergotamine
4.35Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
4.35Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
4.35Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
4.35Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
4.35Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
4.35Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
4.35Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
4.35Single7WC6LSD7WC6-5-HT2A-LSD
4.35Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
4.35Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
4.35Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
4.35Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
4.35Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
4.35Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
4.35Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
4.35Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
4.35Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
4.35Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
4.35Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
4.35Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
4.35Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.35Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.35Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.35Single8GNEKW-63568GNE-A2A-KW-6356-Na
4.35Single8GTGBMK-I1528GTG-CRF1-BMK-I152
4.35Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
4.35Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
4.35Single8S4DCMF-0198S4D-Apelin-CMF-019
4.35Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
4.35Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.35Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.35Single8WGBVU01550418WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
4.35Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
4.35Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
4.35Single9ARYSerotonin9ARY-5-HT2A-Serotonin-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
4.35Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
4.35Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35Single9HAPTolvaptan9HAP-V2-Tolvaptan
4.35Single9HC04YI9HC0-mGlu5-4YI
4.35Single9K07DSO-5a9K07-BB3-DSO-5a-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.35Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
4.35Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
4.35Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
4.35Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
4.35Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
4.35Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
4.35Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
4.35Consensusa3_on_gpOrthosteric Liganda3a_on_gp
4.35Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
4.35Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
4.35Consensusadenosine_offOrthosteric Liganda1_off a2_off
4.35Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
4.35Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
4.35Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
4.35Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
4.35Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
4.35Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
4.35Consensusamine_offonOrthosteric Ligandamine_off amine_on
4.35Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
4.35Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
4.35Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
4.35Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
4.35Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
4.35Consensusblt_offOrthosteric Ligandblt1_off
4.35Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
4.35Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
4.35Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
4.35Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
4.35Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
4.35Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.35Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.35Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
4.35Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
4.35Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
4.17Single3P0GBI1671073P0G-β2-BI167107
4.17Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
4.17Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
4.17Single4DJHJDTic4DJH-κ-JDTic
4.17Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
4.17Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
4.17Single5D5AS-Carazolol5D5A-β2-S-Carazolol
4.17Single5D5BS-Carazolol5D5B-β2-S-Carazolol
4.17Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
4.17Single6E59L-7607356E59-NK1-L-760735
4.17Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
4.17Single6H7JIsoprenaline6H7J-β1-Isoprenaline
4.17Single6J20Aprepitant6J20-NK1-Aprepitant
4.17Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
4.17Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
4.17Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
4.17Single7B6WCyclazosin7B6W-α1b-Cyclazosin
4.17Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
4.17Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
4.17Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
4.17Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
4.17Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
4.17Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
4.17Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
4.17Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
4.17Single8E0GBU728E0G-μ-BU72
4.17Single8GDBPGE28GDB-EP4-PGE2-Gs/β1/γ2
4.17Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
4.17Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
4.17Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
4.17Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
4.17Single8JD5JNJ-40411813; ADX881788JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
4.17Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
4.17Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
4.17Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
4.17Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
4.17Single8XVLZibotentan8XVL-ETA-Zibotentan
4.17Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
4.17Single8YNTSNAP-948478YNT-MCH1-SNAP-94847
4.17Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
4.17Single9AS9RS130-1809AS9-5-HT2A-RS130-180
4.17Single9ASARS130-1809ASA-5-HT2A-RS130-180-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
4.17Single9BJKNaloxone9BJK-μ-Naloxone-NAM
4.17Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
4.17Single9JMCDS-3801b9JMC-Motilin-DS-3801b-chim(Gs-CtGq)/β1/γ2
4.17Single9UY3Anamorelin9UY3-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
4.17Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
4.17Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
4.17Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
4.17Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
4.17Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
4.17Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
4.17Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
4.17Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
4.17Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
4.17Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
4.17Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
4.00Single3D4STimolol3D4S-β2-Timolol
4.00Single4LDEBI1671074LDE-β2-BI167107
4.00Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
4.00Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
4.00Single5X33BIIL2605X33-BLT1-BIIL260
4.00Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
4.00Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
4.00Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
4.00Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
4.00Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
4.00Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
4.00Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
4.00Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
4.00Single7YITNalfurafine7YIT-κ-Nalfurafine
4.00Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.00Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
4.00Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
4.00Single8GTMBMK-C2038GTM-CRF1-BMK-C203
4.00Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
4.00Single8JJ8Formoterol8JJ8-β2-Formoterol
4.00Single8JWZAB9288JWZ-A2A-AB928-Na
4.00Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
4.00Single9M4QDoxazosin9M4Q-Alpha1A-Doxazosin
4.00Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
4.00Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
4.00Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
4.00Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
4.00Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
4.00Consensuslpl_offOrthosteric Ligands1p_off lpa_off
4.00Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
4.00Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
4.00Consensusorexin_onOrthosteric Ligandox2_on
4.00Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
4.00Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
3.85Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
3.85Single5CGDHTL142425CGD-mGlu5-HTL14242
3.85Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
3.85Single5X93K-87945X93-ETB-K-8794
3.85Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
3.85Single6H7LDobutamine6H7L-β1-Dobutamine
3.85Single6K1QIRL25006K1Q-ETB-IRL2500
3.85Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
3.85Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
3.85Single8S2TIsoprenaline8S2T-β1-Isoprenaline-chim(NtGi1-Gs)/β1/γ2
3.85Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
3.85Single8XVJMacitentan8XVJ-ETA-Macitentan
3.85Single9AS02-bromo-LSD9AS0-5-HT2A-2-bromo-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
3.85Single9CGJC6-Quino9CGJ-δ-C6-Quino-Gi1/β1/γ2
3.85Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
3.85Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
3.85Consensusendothelin_offOrthosteric Ligandetb_off
3.85Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
3.85Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
3.85Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
3.70Single6PT3DPI-2876PT3-δ-DPI-287
3.70Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
3.70Single8QJ2pN1628QJ2-MC4-pN162-Gs
3.70Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
3.70Single9CGKC5-Quino9CGK-δ-C5-Quino-Gi1/β1/γ2
3.57Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
3.57Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
3.57Single8PKMBefiradol8PKM-5-HT1A-Befiradol-Gi1/β1/γ1
3.57Single8WKYPG-9348WKY-MC4-PG-934
3.57Single9M4TSilodosin9M4T-Alpha1A-Silodosin
3.45Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
3.45Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
3.45Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
3.45Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
3.33Single6PT2KGCHM076PT2-δ-KGCHM07
3.33Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
3.33Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
3.33Consensusclass-b1_class-b2_cons_onOrthosteric Ligandclass-b1_on class-b2_on
3.33Consensusclass-b1_class-b2_cons_on_gpOrthosteric Ligandclass-b1_on_gp class-b2_on_gp

Consensus Members
Id Members
7WUI 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
7WUQ 7WUQ-ADGRG2-Gs/β1/γ2
7XKF 7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
Net Summary
Imin 3.82667
Number of Linked Nodes 901
Number of Links 1053
Number of Hubs 173
Number of Links mediated by Hubs 647
Number of Communities 24
Number of Nodes involved in Communities 195
Number of Links involved in Communities 270
Path Summary
Number Of Nodes in MetaPath 86
Number Of Links MetaPath 85
Number of Shortest Paths 3354656
Length Of Smallest Path 3
Average Path Length 37.3763
Length of Longest Path 82
Minimum Path Strength 0.743333
Average Path Strength 7.2653
Maximum Path Strength 25.8517
Minimum Path Correlation 0.7
Average Path Correlation 0.981639
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.44928
Average % Of Corr. Nodes 29.7714
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 53.6379
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following consensuses:
IdComponents
adgrg_on_gpadgrg2_on_gp
adgrg4_on_gp



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