Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
1G.HN.40 8.3575417
2G.HN.47 3.174515
3G.hns1.01 5.528514
4G.S1.02 7.68476
5G.S1.03 6.93419
6G.S1.06 5.26408
7G.s1h1.05 2.64559
8G.H1.08 5.696509
9G.S2.06 5.2275409
10G.S2.08 6.045476
11G.S3.03 5.992578
12G.S3.04 6.66417
13G.S3.05 6.8275408
14G.S3.06 7.742517
15G.H2.06 6.755619
16G.H2.07 6.0925409
17G.h2s4.01 7.14667619
18G.h2s4.03 2.945616
19G.h2s4.04 3.6325419
20G.S4.03 4.25557
21G.S4.04 5.17833609
22G.s4h3.01 4.1625406
23G.H3.03 3.545434
24G.H3.06 5.194536
25G.H3.09 5.01429739
26G.H3.13 8.794536
27G.H3.17 11.268515
28G.S5.03 5.4525409
29G.S5.04 4.9625409
30G.S5.05 4.18833659
31G.S5.07 4.715459
32G.s5hg.01 5.5325459
33G.hgh4.02 3.95538
34G.hgh4.05 8.324506
35G.hgh4.08 8.7575436
36G.hgh4.11 3.196535
37G.hgh4.21 4.5475404
38G.H4.03 3.14404
39G.H4.04 2.392504
40G.H4.07 7.644535
41G.H4.08 6.8225433
42G.H4.10 10.37537
43G.H4.12 6.476534
44G.H4.13 4.9725433
45G.H4.14 6.8975435
46G.H4.15 5.75833608
47G.H4.16 4.07434
48G.h4s6.02 3.594537
49G.h4s6.20 5.44454
50G.S6.01 3.25435
51G.S6.02 6.5658
52G.S6.04 4.795459
53G.S6.05 8.65535
54G.s6h5.05 5.5425459
55G.H5.05 4.4775475
56G.H5.06 4.3775454
57G.H5.07 3.294559
58G.H5.08 5.87143778
59G.H5.12 4.498577
60G.H5.17 7.51333655
61G.H5.19 5.4925408
62G.H5.20 4.5175428
63G.H5.23 5.42714724
64G.H5.25 3.44667628
65G.H5.26 4.185428
66b.1x4 2.835408
67b.h2x5 4.0925415
68b.lhb1x6 5.198513
69b.lhb1x11 4.222514
70b.b1x3 8.6417
71b.b1x6 8.542519
72b.l1x3 8.53619
73b.b2x1 4.342508
74b.b2x3 5.1416
75b.b2x5 6.66167617
76b.l2x5 8.545415
77b.b3x2 5.5825415
78b.b3x3 5.128518
79b.l3x1 4.495419
80b.l3x2 6.07333619
81b.b4x3 3.376517
82b.b4x4 7.8325418
83b.b4x6 8.4819
84b.b4x7 8.355418
85b.l4x2 9.1475414
86b.b5x3 6.32143719
87b.b5x7 6.0375417
88b.l5x1 3.865418
89b.l5x5 6.735819
90b.b6x1 4.6325409
91b.b6x5 4.79416
92b.l6x1 3.115416
93b.l6x3 4.59416
94b.b7x1 5.28167614
95b.l7x5 3.4854106
96b.b8x4 5.858516
97b.l9x3 5.85429719
98b.l9x5 2.532518
99b.l9x6 6.38718
100b.l9x7 3.995417
101b.b10x2 3.9575406
102b.b10x3 3.69667618
103b.b10x4 3.735466
104b.b10x5 4.305619
105b.l10x1 3.942563
106b.b11x2 5.604517
107b.b11x3 5.32465
108b.b11x4 5.105419
109b.b11x6 5.99519
110b.l11x1 3.74419
111b.l11x2 7.994519
112b.b12x2 5.8675417
113b.b12x3 3.5468
114b.b12x6 8.48714718
115b.b13x3 7.53414
116b.b13x7 6.51567
117b.l13x3 6.7975869
118b.l13x6 8.42519
119b.l13x7 6.4525469
120b.b14x2 2.9125417
121b.b14x3 3.562565
122b.b14x5 3.508565
123b.l14x5 6.994515
124b.l14x6 5.48413
125b.b15x1 5.84669
126b.b15x3 5.88469
127b.l15x1 5.566517
128b.l15x2 5.85569
129b.b16x4 5.77766
130b.b16x6 9.83286768
131b.b16x7 10.06419
132b.b17x3 5.7725465
133b.b17x5 6.69517
134b.b17x7 7.106518
135b.l17x3 9.32719
136b.l17x6 8.644519
137b.l17x7 5.4417
138b.b18x3 5.438518
139b.b18x5 7.1075405
140b.l18x1 6.98429746
141b.l18x2 5.655447
142b.l18x3 7.796545
143b.b19x2 5.88429716
144b.b19x4 5.32833618
145b.l19x1 6.376519
146b.l19x2 7.45619
147b.b20x2 7.326516
148b.b20x3 2.97548
149b.b20x4 10.395618
150b.b20x6 6.98714716
151b.l20x1 5.6075416
152b.l20x2 5.635409
153b.b21x1 6.024517
154b.b21x5 6.35444
155b.b21x7 5.21745
156b.l21x5 6.2075444
157b.l21x8 1.77404
158b.l21x9 5.905446
159b.b22x3 1.74446
160b.b22x5 6.17547
161b.l22x5 7.62519
162b.b23x5 2.3225417
163b.b23x6 7.90857747
164b.l23x1 9.8875416
165b.l23x2 7.59448
166b.b24x3 3.752515
167b.b24x5 4.17333615
168b.b24x6 8.6775448
169b.b25x3 8.0025445
170b.b25x6 3.39403
171b.b25x7 8.645417
172b.l25x3 9.458519
173b.l25x5 3.764517
174b.l25x6 11.925618
175b.l25x7 3.9325417
176b.b26x3 2.82286716
177b.l26x1 5.638517
178b.l26x3 5.4825417
179b.l26x4 2.325419
180b.l26x5 4.61571715
181b.b27x1 3.41416
182b.b27x3 5.5575418
183b.l27x1 10.0929719
184b.l27x2 8.02419
185b.b28x2 6.905414
186b.b28x3 4.55167617
187b.b28x4 4.69167616
188b.b28x6 8.25667619
189b.b28x7 4.945419
190g.h1x1 2.9075402
191g.l1x4 5.385418
192g.h2x9 2.615414
193g.h2x11 7.42446
194g.ctx3 6.744519
195g.ctx4 3.9275417
196g.ctx5 5.05419
197g.ctx6 3.586516
198g.ctx9 4.025416
199g.ctx14 5.262519
200g.ctx15 6.8125419
201g.ctx16 4.52778918
202NT.Q37 2.9275427
203NT.C63 5.4125429
204NT.E66 10.0175426
205NT.W67 7.256527
206NT.L70 4.4825426
207NT.I71 5.52425
208NT.W73 7.94571729
209NT.R75 4.5404
210NT.V84 3.7575425
211NT.C86 3.4775429
212NT.P87 3.60286728
213NT.Y89 4.99425
214NT.I90 5.966526
215NT.F93 7.32143725
216NT.F100 3.774584
217NT.R101 8.55429728
218NT.N104 4.004505
219NT.W109 8.29529
220NT.Y122 5.512525
221NT.D124 3.445485
2221x35 7.66667625
2231x39 4.31426
2241x43 5.476527
2251x47 5.59667628
2261x51 4.22406
2271x54 4.546529
2281x64 4.53333627
229I1x50 3.8675429
2302x45 4.25428
2312x46 6.18629
2322x49 4.0975409
2332x50 11.6725429
2342x52 9.445428
2352x54 4.02729
2362x57 7.17333628
2372x58 4.42407
2382x60 6.114528
2392x64 4.31833627
2402x67 9.03527
2412x68 6.9675428
2422x71 3.2025426
2432x74 4404
2443x33 2.9425426
2453x36 11.7325426
2463x37 6.79427
2473x38 5.81667629
2483x39 6.275625
2493x42 4.61167628
2503x44 7.746527
2513x45 6.358525
2523x46 6.24571729
2533x48 4.178528
2543x53 6.42857729
2553x54 5.6175429
2563x55 11.3925429
2573x57 7.335428
258I2.F269 6.74714777
259I2.F270 7.414526
2604x43 4.6575426
2614x46 4.6325427
2624x50 5.244529
2634x52 5.2075424
2644x53 3.63286729
2654x56 4.26625825
2664x60 5.51625828
2674x64 7.98528
268E2.R305 6.55425
269E2x51 10.29728
270E2x52 4.862526
2715x36 4.4025423
2725x37 8.306526
2735x39 8.00833628
2745x40 8.175427
2755x43 4.4025428
2765x50 3.685429
2775x51 6.9225407
2785x54 8.064529
2796x45 5.5175429
2806x49 6.67629
2816x51 6.0825427
2826x52 7.278528
2836x53 9.46667628
2846x56 4.2507
2857x38 3.486527
2867x42 4.4425428
2877x47 5.26333627
2887x51 4.674526
2897x54 4.195429
2907x57 8.19529
2917x59 4.97428
2928x47 3.2025409
2938x53 5.2075428
294Lig 10.42844320
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1G.hns1.01 b.l3x2 11.22634.6YesYes149
2G.h2s4.03 G.hns1.01 11.83192.3YesYes164
3b.b26x2 b.b2x3 10.08384.86NoYes076
4b.b26x1 b.b26x2 14.6543.44NoNo097
5b.b26x1 b.l27x1 14.8646.18NoYes099
6b.l25x5 b.l27x1 16.25094.52YesYes179
7G.H3.17 b.l25x5 18.52646.78YesYes157
8G.H3.16 G.H3.17 38.21539.28NoYes155
9G.H3.16 G.h3s5.01 89.25193.71NoNo053
10G.h3s5.01 G.h4s6.12 84.79399.6NoNo032
11G.h4s6.10 G.h4s6.12 84.688314.29NoNo032
12G.h4s6.10 G.h4s6.11 1001.68NoNo032
13G.h4s6.11 G.h4s6.20 99.93134.35NoYes024
14b.l25x6 b.l27x1 31.591414.99YesYes189
15G.H3.17 b.l25x6 19.848922.99YesYes158
16b.l23x1 b.l25x6 20.884821.44YesYes168
17G.H3.16 b.l23x1 51.08324.15NoYes156
18G.H5.17 G.h4s6.20 90.73797.2YesYes554
195x64 G.H5.17 90.49937.43NoYes595
205x64 G.H5.16 90.52265.42NoNo096
21G.H5.12 G.H5.16 90.44762.34YesNo076
22G.H5.12 I2.F269 89.36964.28YesYes777
23G.H5.15 I2.F269 91.99083.77NoYes787
24G.H2.04 G.H2.07 17.64778NoYes099
25G.H2.04 G.H3.08 17.63899.72NoNo098
26G.H3.08 G.S4.04 17.63326.09NoYes089
27G.H2.01 b.l13x6 11.38617.15NoYes199
28G.H2.01 b.b12x1 13.59866.47NoNo096
29G.H2.06 b.l9x6 13.35194.78YesYes198
30b.l21x8 b.l23x1 32.54921.68YesYes046
31b.l19x1 b.l21x8 27.50111.68YesYes094
32G.H2.06 b.l19x1 13.04215.53YesYes199
33b.b2x1 b.l27x1 20.45515.79YesYes089
34G.h2s4.02 G.h2s4.03 11.46314.04NoYes186
35G.H3.09 G.S4.04 14.57127.5YesYes099
36G.h4s6.08 G.h4s6.10 15.64445.89NoNo053
37G.H3.13 G.h4s6.08 15.61727.41YesNo065
38G.H5.15 G.H5.19 92.65625.3NoYes088
393x57 G.H5.19 85.849411.57YesYes088
403x57 G.H5.23 44.73563.52YesYes284
413x53 3x57 40.06479.38YesYes298
427x57 G.H5.23 34.9922.98YesYes294
43b.b2x1 b.b6x1 16.15237.18YesYes089
44b.b6x1 b.l7x1 15.59453.49YesNo099
45b.b6x2 b.b7x5 11.08821.82NoNo089
46b.b12x1 b.l13x3 11.71362.74NoYes069
47b.l17x5 b.l19x1 14.84655.89NoYes169
48b.l17x5 b.l19x2 17.82282.94NoYes169
497x53 7x57 34.44412.52NoYes299
502x57 7x53 29.38157.87YesNo289
512x57 3x43 27.56288.46YesNo089
522x60 3x43 53.92029.64YesNo089
532x60 Lig 49.41034.76YesYes280
542x49 3x53 39.26158.46YesYes099
552x49 3x46 38.60282.35YesYes099
562x56 3x46 26.72443.71NoYes299
572x56 3x43 26.74874.47NoNo099
58Lig NT.F93 10.82399.8YesYes205
59Lig NT.Y122 11.41218.38YesYes205
60G.H2.07 b.l9x6 13.47868.68YesYes098
61G.h2s4.02 b.l27x1 11.62215.65NoYes189
62G.H3.09 G.H3.13 16.04233.01YesYes396
63b.b7x5 b.l7x1 14.32762.11NoNo099
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
LigNT.T313.882YesNo0501
LigNT.I323.762YesNo0401
E2.R305NT.T333.882YesNo5712
LigNT.I34112YesNo0301
E2.R305NT.E3511.632YesNo5612
NT.L40NT.Q372.660NoYes3721
NT.I90NT.Q374.122YesYes6721
LigNT.Q373.52YesYes0701
LigNT.I385.872YesNo0501
NT.L70NT.P873.282YesYes6822
NT.I90NT.L702.852YesYes6622
NT.F93NT.L706.092YesYes5612
NT.R101NT.W7321.992YesYes8922
NT.W73NT.Y1226.752YesYes9521
NT.C86NT.P871.882YesYes9822
NT.C86NT.F932.792YesYes9521
NT.C125NT.C867.282NoYes9922
NT.I90NT.P871.692YesYes6822
NT.F93NT.P875.782YesYes5812
NT.F93NT.I9016.332YesYes5612
NT.D92NT.Y915.752NoNo4411
LigNT.Y917.22YesNo0401
LigNT.D9235.92YesNo0401
NT.C125NT.F935.592NoYes9521
NT.F93NT.L1264.872YesNo5311
LigNT.F939.82YesYes0501
NT.A99NT.Y1222.670NoYes7521
NT.A120NT.R1014.152NoYes7822
NT.R101NT.Y1223.092YesYes8521
NT.A120NT.Y1226.672NoYes7521
LigNT.Y1228.382YesYes0501
LigNT.L1262.832YesNo0301
1x25Lig12.852NoYes3010
1x281x322.910NoNo2321
1x29Lig9.010NoYes3010
1x32Lig5.642NoYes3010
1x33Lig5.322NoYes2010
1x351x363.222YesNo5521
1x351x392.442YesYes5622
1x357x382.492YesYes5721
1x36Lig21.242NoYes5010
1x37Lig3.490NoYes2010
1x397x382.832YesYes6721
1x397x425.542YesYes6821
1x431x474.962YesYes7821
1x432x642.422YesYes7721
1x432x685.752YesYes7822
1x437x422.342YesYes7821
1x472x606.172YesYes8811
1x472x649.672YesYes8711
1x472x652.062YesNo8812
1x477x463.822YesNo8912
1x47Lig6.92YesYes8010
2x603x404.862YesNo8611
2x603x439.642YesNo8912
2x603x445.142YesYes8711
2x60Lig4.762YesYes8010
2x642x672.912YesYes7711
2x642x682.82YesYes7812
2x643x362.512YesYes7611
2x64Lig5.62YesYes7010
2x672x685.532YesYes7812
2x673x323.212YesNo7712
2x673x3617.372YesYes7611
2x67Lig16.132YesYes7010
2x713x291.712YesNo6912
2x713x321.72YesNo6712
2x71E2x522.852YesYes6611
2x71Lig6.552YesYes6010
2x75E2x522.732NoYes4611
2x75Lig4.12NoYes4010
E1.E209Lig2.440NoYes4010
3x29E2x507.280NoNo9922
3x334x602.452YesYes6811
3x33E2x501.712YesNo6912
3x33E2x513.682YesYes6812
3x33Lig3.932YesYes6010
3x363x373.772YesYes6711
3x36Lig23.282YesYes6010
3x374x608.222YesYes7811
3x375x398.462YesYes7811
3x37Lig6.712YesYes7010
3x403x4410.552NoYes6711
3x40Lig5.492NoYes6010
3x414x562.772NoYes7522
3x415x433.252NoYes7821
3x445x433.632YesYes7811
3x446x5315.892YesYes7812
3x44Lig3.522YesYes7010
4x565x392.062YesYes5821
4x565x435.022YesYes5821
4x604x6482YesYes8812
4x60E2x516.562YesYes8812
4x605x364.72YesYes8312
4x605x3813.522YesNo8912
4x605x398.682YesYes8811
4x60Lig22YesYes8010
4x64E2x5123.992YesYes8822
4x645x363.762YesYes8322
E2.R305E2x523.492YesYes5611
E2.R305Lig7.22YesYes5010
E2x50E2x523.040NoYes9621
E2x52Lig12.22YesYes6010
E2.S310Lig8.840NoYes7010
5x345x375.230NoYes5621
5x375x385.82YesNo6612
5x375x393.582YesYes6811
5x375x4014.922YesYes6711
5x37Lig122YesYes6010
5x385x407.672NoYes6721
5x395x405.642YesYes8711
5x39Lig19.632YesYes8010
5x40Lig4.472YesYes7010
5x43Lig5.712YesYes8010
5x44Lig4.730NoYes5010
6x567x415.830YesNo7821
7x347x384.652NoYes5711
7x34Lig4.362NoYes5010
7x377x4115.120NoNo7821
7x387x424.242YesYes7811
7x38Lig3.222YesYes7010
7x41Lig6.032NoYes8010
7x42Lig5.652YesYes8010
1x251x261.582NoNo3212
2x75E1.S2311.552NoNo4412
NT.Q37NT.V411.432YesNo7512
NT.I38NT.L421.432NoNo5212
E1.L210NT.I381.430NoNo4521
1x301x331.370NoNo1221

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
90.32Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
58.82Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
58.82Consensusglp2_on_gpOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
58.82Consensussecretin_on_gpOrthosteric Ligand7D3S-Secretin-Secretin-Gs/β1/γ2
56.76Consensuspth1_on_gpOrthosteric Ligand6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
55.88Consensussecretin_onOrthosteric Ligand7D3S-Secretin-Secretin-Gs/β1/γ2
52.94Consensusvpac1_onOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
52.78Consensuspth1_onOrthosteric Ligand6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
52.63Consensusglp1_on_gpOrthosteric Ligand7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
51.43Consensusvpac1_on_gpOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
51.35Consensusgip_onOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
51.35Consensusgip_on_gpOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
50.00Consensusglp1_onOrthosteric Ligand7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
48.65Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
48.65Consensusvpac2_on_gpOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
47.22Consensuspac1_onOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
47.22Consensuspac1_on_gpOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
46.34Consensusgluc_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
45.24Consensusgluc_on_gpOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
45.00Consensuscrf1_on_gpOrthosteric Ligand6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF1-Corticoliberin-Gs/β1/γ2
44.74Consensusctlike_on_gpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
43.24Single9BLWCagrilintide backbone (non-acylated)9BLW-CT (AMY1)-Cagrilintide backbone (non-acylated)-Gs/β1/γ2; RAMP1
43.24Consensuscrf2_on_gpOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
40.91Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
40.00Consensuscrf1_onOrthosteric Ligand6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF1-Corticoliberin-Gs/β1/γ2
39.47Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
39.47Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
38.46Single9BUCCagrilintide9BUC-CT-Cagrilintide-Gs/β1/γ2
38.10Consensuscrf_on_gpOrthosteric Ligandcrf2_on_gp crf1_on_gp
37.84Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ2
37.84Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
37.50Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
36.59Single7RBTTirzepatide7RBT-GIP-Tirzepatide-LSN3556672-chim(NtGi1-Gs)/β1/γ2
36.36Consensusglucagon_on_gpOrthosteric Ligandglp_on_gp gluc_on_gp secretin_on_gp gip_on_gp
36.11Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
35.90Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
35.90Single9BLBCagrilintide backbone (non-acylated)9BLB-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
35.71Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
35.29Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
35.00Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
35.00Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
35.00Consensusglp_onOrthosteric Ligandglp1_on glp2_on
35.00Consensusglp_on_gpOrthosteric Ligandglp1_on_gp glp2_on_gp
34.88Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
34.21Single9BLCCagrilintide backbone (non-acylated)9BLC-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
34.21Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
34.15Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
34.15Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
34.15Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
34.15Single9BTWCagrilintide9BTW-CT (AMY3)-Cagrilintide-Gs/β1/γ2; RAMP3
34.09Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
34.09Consensusglucagon_onOrthosteric Ligandglp_on gluc_on secretin_on gip_on
34.04Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
33.33Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
33.33Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
33.33Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
33.33Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
33.33Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
33.33Consensusclass-a_class-b1_cons_onOrthosteric Ligandclass-a_on class-b1_on
33.33Consensuspth_on_gpOrthosteric Ligandpth1_on_gp pth2_on_gp
32.56Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
32.56Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
32.56Single9AUCCalcitonin gene-related peptide-19AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
32.50Single6FJ3PTH6FJ3-PTH1-PTH
32.50Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
32.50Single9BP3Cagrilintide9BP3-CT (AMY1)-Cagrilintide-Gs/β1/γ2; RAMP1
32.50Single9BUBCagrilintide9BUB-CT-Cagrilintide-Gs/β1/γ2
32.50Consensusvpac_on_gpOrthosteric Ligandvpac1_on_gp vpac2_on_gp
32.35Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
32.35Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
31.82Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
31.71Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
31.71Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
31.71Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
31.71Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
31.58Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
31.58Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
31.43Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
31.43Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
31.43Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
31.25Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
31.11Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
31.11Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
31.11Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
31.11Consensusclass-a_class-b1_cons_on_gpOrthosteric Ligandclass-a_on_gp class-b1_on_gp
30.95Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
30.95Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
30.95Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
30.95Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
30.95Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
30.95Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
30.95Single9BQ3Cagrilintide9BQ3-CT (AMY2)-Cagrilintide-Gs/β1/γ2; RAMP2
30.95Single9BYOExendin-39BYO-GLP-1-Exendin-3-Gs/β1/γ2
30.95Consensusvip-pacap_onOrthosteric Ligandvpac_on pac_on
30.95Consensusvip-pacap_on_gpOrthosteric Ligandvpac_on_gp pac_on_gp
30.77Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
30.77Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
30.77Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
30.77Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
30.77Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
30.77Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
30.77Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
30.77Single9BUDCagrilintide9BUD-CT-Cagrilintide-Gs/β1/γ2
30.56Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
30.43Consensuspth_onOrthosteric Ligandpth1_on pth2_on
30.30Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
30.00Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
30.00Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
30.00Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
30.00Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
30.00Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
30.00Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
30.00Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
30.00Consensuscalcitonin_onOrthosteric Ligandctlike_on
30.00Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
30.00Consensusvpac_onOrthosteric Ligandvpac1_on vpac2_on
29.73Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
29.73Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
29.73Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
29.73Consensuslpl_onOrthosteric Ligands1p_on lpa_on
29.73Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
29.55Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
29.55Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
29.41Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
29.41Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
29.41Consensusclass-b1_on_gpOrthosteric Ligandglucagon_on_gp vip-pacap_on_gp pth_on_gp crf_on_gp calcitonin_on_gp
29.27Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
29.27Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
29.27Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
29.27Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
29.27Single9KFKRelaxin-39KFK-RXFP4-Relaxin-3-Gi2/β1/γ2
29.27Consensuscalcitonin_on_gpOrthosteric Ligandctlike_on_gp
29.27Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
29.27Consensuspac_on_gpOrthosteric Ligandpac1_on_gp
29.17Consensusclass-b1_onOrthosteric Ligandglucagon_on vip-pacap_on pth_on crf_on calcitonin_on
28.95Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
28.95Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
28.89Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
28.89Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
28.89Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
28.57Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
28.57Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
28.57Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
28.57Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
28.57Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
28.57Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
28.57Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
28.57Single9EBIPiclidenoson9EBI-A3A-Piclidenoson-chim(NtGi1L-Gs-CtGi1)/β1/γ2
28.57Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
28.57Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
28.57Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
28.57Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
28.26Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
28.26Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
28.21Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
28.21Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
28.21Consensusangiotensin_onOrthosteric Ligandat1_on
28.21Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
28.21Consensusclass-b1_class-b2_cons_onOrthosteric Ligandclass-b1_on class-b2_on
28.21Consensusclass-b1_class-b2_cons_on_gpOrthosteric Ligandclass-b1_on_gp class-b2_on_gp
27.91Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
27.91Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
27.78Single7UM4AS26747237UM4-5-HT5A-AS2674723
27.50Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
27.50Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
27.50Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
27.50Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
27.50Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
27.50Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
27.50Single8ZBISomatostatin-148ZBI-SST3-Somatostatin-14-Gi1/β1/γ2
27.50Single9EBOGLP-1 (ACPC18)9EBO-GLP-1-GLP-1 (ACPC18)-Gs/β1/γ2
27.50Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
27.50Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
27.50Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
27.50Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
27.50Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
27.50Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
27.27Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
27.27Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
27.27Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
27.27Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
27.03Single3NY9ICI118-5513NY9-β2-ICI118-551
27.03Single4UG2CGS216804UG2-A2A-CGS21680
27.03Single7SK9CCX6627SK9-ACKR3-CCX662
27.03Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
27.03Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
27.03Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
27.03Single9M0RNeuropeptide VF9M0R-NPFF1-Neuropeptide VF-Gi1/β1/γ2
27.03Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
27.03Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
26.83Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
26.83Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
26.83Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
26.83Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
26.83Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
26.83Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
26.83Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
26.83Consensuspac_onOrthosteric Ligandpac1_on
26.67Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
26.47Single7LD3Adenosine7LD3-A1-Adenosine-MIPS521-Gi2/β1/γ2
26.47Consensusa3_on_gpOrthosteric Liganda3a_on_gp
26.47Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
26.47Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
26.47Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
26.47Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
26.47Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
26.47Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
26.47Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
26.32Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
26.32Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
26.32Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
26.32Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
26.32Single8YWFRetatrutide8YWF-GLP-1-Retatrutide-chim(NtGi1-Gs)/β1/γ2
26.32Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
26.32Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
26.32Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
26.32Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
26.19Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
26.19Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
26.19Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
26.19Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
26.19Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
26.19Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
26.19Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
26.19Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
25.71Single5V54Methiothepin5V54-5-HT1B-Methiothepin
25.71Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
25.71Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
25.71Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
25.71Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
25.71Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
25.71Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
25.71Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
25.71Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
25.71Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
25.71Consensus5ht1_offOrthosteric Ligand5ht1b_off
25.71Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
25.71Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
25.71Consensusa2_onOrthosteric Liganda2b_on
25.71Consensusa2_on_gpOrthosteric Liganda2b_on_gp
25.71Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
25.71Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
25.71Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
25.71Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
25.71Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
25.71Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
25.71Consensusrelaxin_onOrthosteric Ligandrxfp4_on
25.71Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
25.71Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
25.71Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
25.64Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
25.64Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
25.64Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
25.64Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
25.64Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
25.64Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
25.64Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
25.58Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
25.58Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
25.58Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
25.58Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
25.58Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
25.58Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
25.58Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
25.58Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
25.58Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
25.58Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
25.53Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
25.00Single5WF5UK-4320975WF5-A2A-UK-432097
25.00Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
25.00Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
25.00Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
25.00Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
25.00Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
25.00Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
25.00Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
25.00Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
25.00Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
25.00Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
25.00Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
25.00Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
25.00Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
25.00Consensusbradykinin_onOrthosteric Ligandbk2_on
25.00Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
25.00Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
25.00Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
25.00Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
25.00Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
25.00Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
25.00Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
25.00Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
25.00Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
25.00Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
24.39Single6JODAngiotensin II6JOD-AT2-Angiotensin II
24.39Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
24.39Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
24.39Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
24.39Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
24.39Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
24.39Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
24.39Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
24.39Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
24.39Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
24.39Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
24.32Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
24.32Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
24.32Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
24.32Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
24.32Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
24.32Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
24.32Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
24.32Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
24.32Single9C0KExendin-49C0K-GLP-1-Exendin-4-Gs/β1/γ2
24.32Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
24.32Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
24.32Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
24.24Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
24.24Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
24.24Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
24.24Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
24.24Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
23.81Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
23.81Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
23.81Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
23.81Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
23.81Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
23.81Single9JFYhNPSF9JFY-NPFF2-hNPSF-Gi1/β1/γ2
23.68Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
23.68Single5ZTYAM102575ZTY-CB2-AM10257
23.68Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
23.68Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
23.68Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
23.68Single9IZASCH9002719IZA-HCA2-SCH900271-Gi1/β1/γ2
23.68Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
23.68Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
23.68Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
23.68Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
23.53Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
23.53Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
23.53Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
23.53Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
23.53Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
23.53Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
23.53Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
23.53Consensusa3_onOrthosteric Liganda3a_on
23.53Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
23.53Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
23.53Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
23.53Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
23.53Consensusblt_onOrthosteric Ligandblt1_on
23.53Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
23.53Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
23.53Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
23.53Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
23.53Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
23.53Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
23.53Consensushca_on_gpOrthosteric Ligandhca2_on_gp
23.53Consensusleukotriene_onOrthosteric Ligandblt_on
23.53Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
23.40Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
23.40Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
23.26Single4XT3Fractalkine4XT3-US28-Fractalkine
23.26Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
23.26Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
23.26Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
23.26Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
23.26Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
23.08Single4XT1Fractalkine4XT1-US28-Fractalkine
23.08Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
23.08Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
23.08Single7QA8Peptide7QA8-STE2-Peptide
23.08Single7QA8Peptide7QA8-STE2-Peptide
23.08Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
23.08Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
23.08Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
23.08Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
23.08Single8WDTphotoNECA8WDT-A2A-photoNECA
23.08Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
23.08Single9BUECagrilintide9BUE-CT-Cagrilintide-Gs/β1/γ2
23.08Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
22.86Single5C1MBU725C1M-μ-BU72
22.86Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
22.86Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
22.86Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
22.86Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
22.86Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
22.86Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
22.86Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
22.86Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
22.86Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
22.86Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
22.86Single8XYKVUF106618XYK-CXCR3-VUF10661-Go/β1/γ2
22.86Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
22.86Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
22.86Single9CIBFCH-22964139CIB-HCA2-FCH-2296413
22.86Single9EE8Adenosine9EE8-A2A-Adenosine-Gs/β1/γ2
22.86Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
22.86Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
22.73Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
22.73Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
22.73Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
22.50Single3QAKUK-4320973QAK-A2A-UK-432097
22.50Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
22.50Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
22.50Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
22.50Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
22.50Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
22.50Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
22.50Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
22.50Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
22.50Single9E82SDF-1-beta9E82-ACKR3-SDF-1-β-Arrestin2
22.50Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
22.50Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
22.50Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
22.22Single2YDVNECA2YDV-A2A-NECA
22.22Single4UHRCGS216804UHR-A2A-CGS21680
22.22Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
22.22Single5G53NECA5G53-A2A-NECA-Gs
22.22Single5XR8AM8415XR8-CB1-AM841
22.22Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
22.22Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
22.22Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
22.22Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
22.22Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
22.22Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
22.22Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
22.22Single8E0GBU728E0G-μ-BU72
22.22Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
22.22Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
22.22Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
22.22Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
22.22Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
22.22Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
22.22Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
22.22Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
22.22Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
22.22Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
22.22Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
22.22Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
22.22Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
22.22Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
22.22Consensuslpa_onOrthosteric Ligandlpa1_on
22.22Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
22.22Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
22.22Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
21.95Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
21.95Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.95Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
21.95Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
21.95Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
21.95Single9B5YLong-Acting PTH9B5Y-PTH1-Long-Acting PTH-chim(NtGi1-Gq)/β1/γ2
21.88Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
21.88Single8K5BNiacin8K5B-HCA2-Niacin
21.88Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
21.74Single5GLHEndothelin-15GLH-ETB-Endothelin-1
21.74Single6IGKEndothelin-36IGK-ETB-Endothelin-3
21.74Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
21.62Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
21.62Single3D4STimolol3D4S-β2-Timolol
21.62Single5CXVTiotropium5CXV-M1-Tiotropium
21.62Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
21.62Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
21.62Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
21.62Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
21.62Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
21.62Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
21.62Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
21.62Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
21.62Single7YITNalfurafine7YIT-κ-Nalfurafine
21.62Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
21.62Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
21.62Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
21.62Single8XYIVUF106618XYI-CXCR3-VUF10661
21.62Single9DGIZ85267113509DGI-CB1-Z8526711350
21.62Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
21.62Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
21.62Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
21.62Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
21.62Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
21.62Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
21.62Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
21.62Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
21.62Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
21.62Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
21.62Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
21.62Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
21.62Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
21.62Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
21.62Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
21.43Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
21.43Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
21.43Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
21.21Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
21.21Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
21.21Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
21.21Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
21.21Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
21.21Single9EBHAdenosine9EBH-A3A-Adenosine-Gi1/β1/γ2
21.05Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
21.05Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
21.05Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
21.05Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
21.05Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
21.05Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
21.05Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
21.05Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
21.05Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
21.05Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
21.05Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
21.05Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
21.05Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
21.05Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.05Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
21.05Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
21.05Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
21.05Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
20.93Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
20.93Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
20.93Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
20.93Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
20.93Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
20.93Single8ZRTET-18ZRT-ETB-ET-1
20.93Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
20.93Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
20.93Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
20.93Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
20.83Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
20.59Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
20.59Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
20.59Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
20.59Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.59Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
20.59Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
20.59Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
20.59Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
20.59Single8K5CAcipimox8K5C-HCA2-Acipimox
20.59Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
20.59Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.59Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
20.59Consensushca_onOrthosteric Ligandhca2_on
20.51Single5WF6UK-4320975WF6-A2A-UK-432097
20.51Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
20.51Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
20.51Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
20.51Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
20.51Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
20.51Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
20.51Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
20.51Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
20.51Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
20.51Single9JH6C20:0 Ceramide9JH6-CysLT2-C20:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
20.51Single9V2NMacimorelin9V2N-Ghrelin-Macimorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
20.45Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
20.45Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
20.45Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
20.41Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
20.00Single4IARErgotamine4IAR-5-HT1B-Ergotamine
20.00Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
20.00Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
20.00Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
20.00Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
20.00Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
20.00Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
20.00Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
20.00Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
20.00Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
20.00Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
20.00Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
20.00Single7V3ZCP559407V3Z-CB1-CP55940
20.00Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
20.00Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
20.00Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
20.00Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
20.00Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
20.00Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
20.00Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
20.00Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
20.00Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
20.00Single8K5DGSK2560738K5D-HCA2-GSK256073
20.00Single8PJKST1718PJK-5-HT1A-ST171-Gi1/β1/γ1
20.00Single8T1WCVN4248T1W-GPR6-CVN424
20.00Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
20.00Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
20.00Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
20.00Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
20.00Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
20.00Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single9BUYLM1899BUY-β2-LM189-Gi1/β1/γ2
20.00Single9IVGGLP-1 (Truncated)9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
20.00Single9IZCMK19039IZC-HCA2-MK1903-Gi1/β1/γ2
20.00Single9KFJPubChem 1383196749KFJ-RXFP3-PubChem 138319674-Gi2/β1/γ2
20.00Single9M4TSilodosin9M4T-Alpha1A-Silodosin
20.00Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
20.00Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
20.00Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
20.00Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
20.00Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
20.00Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
19.61Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
19.61Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
19.57Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
19.57Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
19.57Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
19.57Consensusendothelin_onOrthosteric Ligandetb_on eta_on
19.51Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
19.51Single6HLOAprepitant6HLO-NK1-Aprepitant
19.51Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
19.51Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
19.51Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
19.51Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
19.51Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
19.51Single9IK8SST analogue9IK8-SST1-SST analogue-Gi1/β1/γ2
19.51Single9IQVMuscarinic toxin 39IQV-Alpha1A-Muscarinic toxin 3
19.51Single9J0FNADH9J0F-P2Y14-NADH-Gi1/β1/γ2
19.51Single9KFIRelaxin-39KFI-RXFP3-Relaxin-3-Gi2/β1/γ2
19.51Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
19.51Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
19.44Single2YCWS-Carazolol2YCW-β1-S-Carazolol
19.44Single4NTJAZD12834NTJ-P2Y12-AZD1283
19.44Single5D6LS-Carazolol5D6L-β2-S-Carazolol
19.44Single5JQHS-Carazolol5JQH-β2-S-Carazolol
19.44Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
19.44Single5TVNLSD5TVN-5-HT2B-LSD
19.44Single5X7DS-Carazolol5X7D-β2-S-Carazolol-Cmpd-15
19.44Single6PS6Timolol6PS6-β2-Timolol
19.44Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
19.44Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
19.44Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
19.44Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
19.44Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
19.44Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
19.44Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
19.44Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
19.44Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
19.44Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
19.44Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
19.44Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.44Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.44Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.44Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
19.44Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
19.44Single8TF5Oleic acid8TF5-GPR6-Oleic acid
19.44Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.44Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.44Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
19.44Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
19.44Single9ARYSerotonin9ARY-5-HT2A-Serotonin-chim(NtGi1-Gs-CtGq)/β1/γ2
19.44Single9DYDAsenapine9DYD-5-HT1A-Asenapine-Go/β1/γ2
19.44Single9DYFAsenapine9DYF-5-HT1A-Asenapine-Gi1/β1/γ2
19.44Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
19.44Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
19.44Single9F33FOB02-04A9F33-D3-FOB02-04A-Go/β1/γ2
19.44Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
19.44Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
19.44Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
19.44Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
19.44Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
19.44Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
19.44Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
19.44Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
19.44Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
19.44Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
19.44Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
19.44Consensustrace-amine_onOrthosteric Ligandta1_on
19.15Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
19.15Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
19.15Consensusbombesin_onOrthosteric Ligandbb2_on
19.15Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
19.15Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
19.05Single6PT2KGCHM076PT2-δ-KGCHM07
19.05Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
19.05Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
19.05Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
19.05Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
19.05Single9U4WGonadoliberin-19U4W-GnRH1-Gonadoliberin-1-chim(NtGi1L-Gs-CtGq)/β1/γ2
19.05Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
19.05Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
18.92Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
18.92Single4U15Tiotropium4U15-M3-Tiotropium
18.92Single5D5AS-Carazolol5D5A-β2-S-Carazolol
18.92Single5D5BS-Carazolol5D5B-β2-S-Carazolol
18.92Single5XRAAM115425XRA-CB1-AM11542
18.92Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
18.92Single6J21Aprepitant6J21-NK1-Aprepitant
18.92Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
18.92Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
18.92Single6OL9Tiotropium6OL9-M5-Tiotropium
18.92Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
18.92Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
18.92Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
18.92Single7FEECP559407FEE-CB1-CP55940-ZCZ011
18.92Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
18.92Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
18.92Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
18.92Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
18.92Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
18.92Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
18.92Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
18.92Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
18.92Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
18.92Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
18.92Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
18.92Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
18.92Single8Y73Peptide8Y73-μ-Peptide-MPAM-15-Gi1/β1/γ2
18.92Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
18.92Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
18.92Single9BJKNaloxone9BJK-μ-Naloxone-NAM
18.92Single9EGOYVF9EGO-CB1-YVF-Gi1/β1/γ2
18.92Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
18.92Single9IK9SST analogue9IK9-SST1-SST analogue-Gi1/β1/γ2
18.92Single9JMCDS-3801b9JMC-Motilin-DS-3801b-chim(Gs-CtGq)/β1/γ2
18.92Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
18.92Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
18.92Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
18.92Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
18.92Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
18.92Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
18.92Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
18.92Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
18.92Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
18.92Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
18.92Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
18.92Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
18.92Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
18.92Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
18.92Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
18.92Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
18.92Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
18.92Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
18.75Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
18.75Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
18.75Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
18.75Single9JHJC18:0 Ceramide9JHJ-FPR2-ALX-C18:0 Ceramide-Gi1/β1/γ2
18.75Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
18.75Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
18.75Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
18.60Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
18.60Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
18.60Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
18.60Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
18.60Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
18.60Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
18.60Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
18.60Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
18.60Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
18.60Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
18.60Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
18.60Consensusvasop-oxy_onOrthosteric Ligandv2_on
18.60Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
18.42Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
18.42Single4PY02MeSATP4PY0-P2Y12-2MeSATP
18.42Single4RWADIPP-NH24RWA-δ-DIPP-NH2
18.42Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
18.42Single6A93Risperidone6A93-5-HT2A-Risperidone
18.42Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
18.42Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
18.42Single6KQICP559406KQI-CB1-CP55940-Org27569
18.42Single6OS2TRV0266OS2-AT1-TRV026
18.42Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
18.42Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
18.42Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
18.42Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
18.42Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
18.42Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
18.42Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
18.42Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
18.42Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
18.42Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.42Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
18.42Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
18.42Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
18.42Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
18.42Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
18.42Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
18.42Single8JD3JNJ-404118138JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
18.42Single8JJ8Formoterol8JJ8-β2-Formoterol
18.42Single8JWY2-1188JWY-A2A-2-118
18.42Single8JWZAB9288JWZ-A2A-AB928-Na
18.42Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
18.42Single8Y6WTUG-13758Y6W-FFA2-TUG-1375-4-CMTB-Gi1/β1/γ2
18.42Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
18.42Single9M4QDoxazosin9M4Q-Alpha1A-Doxazosin
18.42Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
18.42Consensusalpha1_offOrthosteric Ligandalpha1a_off
18.42Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
18.42Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
18.42Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
18.42Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
18.42Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
18.42Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
18.42Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
18.42Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
18.42Consensuslpa_offOrthosteric Ligandlpa1_off
18.42Consensuslpl_offOrthosteric Ligands1p_off lpa_off
18.42Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
18.42Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
18.42Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
18.42Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
18.18Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
18.18Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
18.18Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
18.18Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
18.18Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
18.18Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
18.18Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
18.18Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
18.18Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
18.18Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
17.95Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
17.95Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
17.95Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
17.95Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
17.95Single7EZCUKA7EZC-A2A-UKA
17.95Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
17.95Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
17.95Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
17.95Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
17.95Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.95Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
17.95Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
17.95Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
17.95Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
17.95Single8S2TIsoprenaline8S2T-β1-Isoprenaline-chim(NtGi1-Gs)/β1/γ2
17.95Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
17.95Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
17.95Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
17.95Single8ZWGJR14a8ZWG-C3aB-JR14a-Gi1/β1/γ2
17.95Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
17.95Single9AS02-bromo-LSD9AS0-5-HT2A-2-bromo-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
17.95Single9DYEBuspirone9DYE-5-HT1A-Buspirone-Go/β1/γ2
17.95Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
17.95Single9M54Neuropeptide VF9M54-NPFF2-Neuropeptide VF-Gi1/β1/γ2
17.95Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
17.95Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
17.95Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
17.95Consensusprostanoid_offOrthosteric Ligandep_off dp_off
17.78Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
17.78Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
17.78Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
17.78Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
17.78Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
17.65Single3PWHZM-2413853PWH-A2A-ZM-241385
17.65Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
17.65Single5ZKQABT-4915ZKQ-PAF-ABT-491
17.65Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
17.65Single6ME9Ramelteon6ME9-MT2-Ramelteon
17.65Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
17.65Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
17.65Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
17.65Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
17.65Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
17.65Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
17.65Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
17.65Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
17.65Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
17.65Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
17.65Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
17.65Single8IWESpermidine8IWE-TA9-Spermidine
17.65Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
17.65Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
17.65Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
17.65Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
17.65Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
17.65Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
17.65Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
17.65Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
17.65Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
17.65Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
17.65Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
17.65Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
17.65Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
17.54Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
17.50Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
17.50Single6PT3DPI-2876PT3-δ-DPI-287
17.50Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
17.50Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
17.50Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
17.50Single7XN9L-054,5227XN9-SST2-L-054,522
17.50Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
17.50Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
17.50Single8QJ2pN1628QJ2-MC4-pN162-Gs
17.50Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
17.50Single8X5YAstemizole8X5Y-H1-Astemizole
17.50Single8Y72Peptide8Y72-μ-Peptide-BMS-986122-Gi1/β1/γ2
17.50Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
17.50Single9MD1Buspirone9MD1-5-HT1A-Buspirone-Gz/β1/γ2
17.50Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
17.50Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
17.50Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
17.39Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
17.14Single2YDOAdenosine2YDO-A2A-Adenosine
17.14Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
17.14Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
17.14Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
17.14Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
17.14Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
17.14Single6PS0S-Carazolol6PS0-β2-S-Carazolol
17.14Single6PS4ICI118-5516PS4-β2-ICI118-551
17.14Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
17.14Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
17.14Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
17.14Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
17.14Single7UL3Famotidine7UL3-H2-Famotidine
17.14Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
17.14Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
17.14Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
17.14Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
17.14Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
17.14Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
17.14Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
17.14Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
17.14Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
17.14Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
17.14Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
17.14Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
17.14Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
17.14Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
17.14Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
17.14Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
17.14Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
17.14Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
17.14Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
17.14Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
17.14Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
17.14Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
17.14Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
17.14Single9K0KUTP9K0K-P2Y4-UTP-chim(NtGi1-Gs-CtGq)/β1/γ2
17.14Single9M2FNeuropeptide FF9M2F-NPFF1-Neuropeptide FF-Gi1/β1/γ2
17.07Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
17.07Single7F8XNN90567F8X-CCKA-NN9056
17.07Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
17.07Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
17.07Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
17.07Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
17.07Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
17.07Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
17.07Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
17.07Single8PKMBefiradol8PKM-5-HT1A-Befiradol-Gi1/β1/γ1
17.07Single8U4OCXCL128U4O-CXCR4-CXCL12-Gi1/β1/γ2
17.07Single8ZBJSomatostatin-148ZBJ-SST5-Somatostatin-14-Gi1/β1/γ2
17.07Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
17.07Single9J0IUDP-Glucuronic acid9J0I-P2Y14-UDP-Glucuronic acid-Gi1/β1/γ2
17.07Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
17.07Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
17.07Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
17.07Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
17.02Single6IGLIRL16206IGL-ETB-IRL1620
17.02Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
17.02Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
17.02Single8IY6Endothelin-18IY6-ETB-Endothelin-1
17.02Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
16.67Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
16.67Single2Y04Salbutamol2Y04-β1-Salbutamol
16.67Single3NY8ICI118-5513NY8-β2-ICI118-551
16.67Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
16.67Single4EJ4Naltrindole4EJ4-δ-Naltrindole
16.67Single4GBRS-Carazolol4GBR-β2-S-Carazolol
16.67Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
16.67Single4QKX35V4QKX-β2-35V
16.67Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
16.67Single4YAYZD-71554YAY-AT1-ZD-7155
16.67Single5DSGTiotropium5DSG-M4-Tiotropium
16.67Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
16.67Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
16.67Single5UIGCmpd-15UIG-A2A-Cmpd-1
16.67Single6H7MSalbutamol6H7M-β1-Salbutamol
16.67Single6PS1Timolol6PS1-β2-Timolol
16.67Single6TOTLemborexant6TOT-OX1-Lemborexant
16.67Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single6XBM5LWE6XBM-SMO-5LWE-Gi1/β1/γ2
16.67Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
16.67Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
16.67Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
16.67Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
16.67Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
16.67Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
16.67Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
16.67Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
16.67Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
16.67Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
16.67Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
16.67Single7UL4Alvimopan7UL4-μ-Alvimopan
16.67Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
16.67Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
16.67Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
16.67Single7XNACYN1548067XNA-SST2-CYN154806
16.67Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
16.67Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
16.67Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
16.67Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
16.67Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
16.67Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
16.67Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.67Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.67Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.67Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.67Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.67Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.67Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.67Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.67Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.67Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.67Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
16.67Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
16.67Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
16.67Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
16.67Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
16.67Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
16.67Single8JXRLSD8JXR-D1-LSD
16.67Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
16.67Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.67Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.67Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.67Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.67Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
16.67Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
16.67Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
16.67Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
16.67Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
16.67Single8YN8Proxyfan8YN8-H3-Proxyfan-Go/β1/γ2
16.67Single9AS1DMT9AS1-5-HT2A-DMT
16.67Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
16.67Single9CHXS-Carazolol9CHX-β2-S-Carazolol
16.67Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
16.67Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
16.67Single9H37A1IR09H37-A2A-A1IR0-Na
16.67Single9IQSMuscarinic toxin 39IQS-M4-Muscarinic toxin 3
16.67Single9IYAONO-97105319IYA-GPR55-ONO-9710531
16.67Single9JEAAtropine9JEA-M1-Atropine
16.67Single9PQD(6m)-1-methyl-6-(1,2,5,6-tetrahydropyridin-3-yl)-1h-indole9PQD-α2a-(6m)-1-methyl-6-(1,2,5,6-tetrahydropyridin-3-yl)-1h-indole
16.67Consensus5ht5_onOrthosteric Ligand5ht5a_on
16.67Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
16.67Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
16.67Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
16.67Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
16.67Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
16.67Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
16.67Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
16.67Consensusdopamine_offOrthosteric Ligandd2_off d3_off
16.67Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
16.67Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
16.67Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
16.67Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
16.67Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
16.67Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
16.67Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
16.67Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
16.67Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
16.67Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
16.67Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
16.67Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
16.67Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
16.67Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
16.33Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
16.33Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
16.28Single3OE0CVX153OE0-CXCR4-CVX15
16.28Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
16.28Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
16.28Single9M1OMorphine-Modulating Neuropeptide B9M1O-NPFF2-Morphine-Modulating Neuropeptide B-Gi1/β1/γ2
16.28Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
16.28Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
16.28Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
16.28Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
16.22Single2RH1S-Carazolol2RH1-β2-S-Carazolol
16.22Single2Y03Isoprenaline2Y03-β1-Isoprenaline
16.22Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
16.22Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
16.22Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
16.22Single5WIUNemonapride5WIU-D4-Nemonapride
16.22Single5WIVNemonapride5WIV-D4-Nemonapride-Na
16.22Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
16.22Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
16.22Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
16.22Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
16.22Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
16.22Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
16.22Single6TP6Filorexant6TP6-OX1-Filorexant
16.22Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
16.22Single7C4SS1P7C4S-S1P3-S1P
16.22Single7C61Ergotamine7C61-5-HT1B-Ergotamine
16.22Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
16.22Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
16.22Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
16.22Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
16.22Single7SINNPS-21437SIN-CaS-NPS-2143
16.22Single7SINNPS-21437SIN-CaS-NPS-2143
16.22Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
16.22Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
16.22Single7WC6LSD7WC6-5-HT2A-LSD
16.22Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
16.22Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.22Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
16.22Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
16.22Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.22Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
16.22Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
16.22Single8JXSPF-61428JXS-D1-PF-6142
16.22Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
16.22Single8S4DCMF-0198S4D-Apelin-CMF-019
16.22Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
16.22Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
16.22Single8WGBVU01550418WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
16.22Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
16.22Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
16.22Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
16.22Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
16.22Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
16.22Single8ZMFA1L108ZMF-5-HT2C-A1L10
16.22Single9ARZ2-bromo-LSD9ARZ-5-HT2A-2-bromo-LSD
16.22Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
16.22Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
16.22Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
16.22Single9EHSLUF76029EHS-A3A-LUF7602
16.22Single9GE2ML1849GE2-GPR55-ML184-chim(NtGi1-G13)/β1/γ2
16.22Single9I52A1IZU9I52-D1-A1IZU-Gs/β1/γ2
16.22Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
16.22Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
16.22Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
16.22Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
16.22Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
16.22Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
16.22Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
16.22Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
16.22Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
16.22Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
16.22Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
16.22Consensusamine_offonOrthosteric Ligandamine_off amine_on
16.22Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
16.22Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
16.22Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
16.22Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
16.22Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
16.22Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
16.22Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
16.22Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
16.22Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
16.22Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.22Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.22Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
15.91Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
15.91Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
15.91Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
15.91Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
15.91Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
15.91Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
15.79Single3P0GBI1671073P0G-β2-BI167107
15.79Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
15.79Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
15.79Single4DJHJDTic4DJH-κ-JDTic
15.79Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
15.79Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
15.79Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
15.79Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
15.79Single6H7JIsoprenaline6H7J-β1-Isoprenaline
15.79Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
15.79Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
15.79Single6OS1TRV0266OS1-AT1-TRV026
15.79Single6WGTLSD6WGT-5-HT2A-LSD
15.79Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
15.79Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
15.79Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
15.79Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
15.79Single7P2L4YI7P2L-mGlu5-4YI
15.79Single7TUYGSK682753A7TUY-GPR183-GSK682753A
15.79Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
15.79Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
15.79Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
15.79Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
15.79Single8EA0Iperoxo8EA0-M3-Iperoxo
15.79Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
15.79Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
15.79Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
15.79Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
15.79Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
15.79Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
15.79Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
15.79Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
15.79Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
15.79Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
15.79Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
15.79Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
15.79Single9AS9RS130-1809AS9-5-HT2A-RS130-180
15.79Single9ASARS130-1809ASA-5-HT2A-RS130-180-chim(NtGi1-Gs-CtGq)/β1/γ2
15.79Single9I54A1IZV9I54-D1-A1IZV-Gs/β1/γ2
15.79Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
15.79Single9UY3Anamorelin9UY3-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
15.79Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
15.79Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
15.79Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
15.79Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
15.79Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
15.62Single9EE9Adenosine9EE9-A2A-Adenosine-Gs/β1/γ2
15.56Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
15.56Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
15.56Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
15.56Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
15.56Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
15.56Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
15.38Single4AMIBucindolol4AMI-β1-Bucindolol
15.38Single4LDEBI1671074LDE-β2-BI167107
15.38Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
15.38Single4XEENeurotensin4XEE-NTS1-Neurotensin
15.38Single4XESNeurotensin4XES-NTS1-Neurotensin
15.38Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
15.38Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
15.38Single5TZYMK8666; AP85TZY-FFA1-MK8666; AP8
15.38Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
15.38Single6MXTSalmeterol6MXT-β2-Salmeterol
15.38Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
15.38Single6YVRNTS8-136YVR-NTS1-NTS8-13
15.38Single6ZG4HTL00099366ZG4-M1-HTL0009936
15.38Single7DFPSpiperone7DFP-D2-Spiperone
15.38Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
15.38Single7K15MKD0467K15-BLT1-MKD046-Na
15.38Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
15.38Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
15.38Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
15.38Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.38Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
15.38Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
15.38Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
15.38Single8JJLOlodaterol8JJL-β2-Olodaterol
15.38Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
15.38Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
15.38Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.38Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
15.38Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
15.38Single9CM3TUG-13759CM3-FFA2-TUG-1375-Compound 187-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.38Single9GL2Befiradol9GL2-5-HT1A-Befiradol-Gs/β1/γ2
15.38Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
15.38Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
15.38Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
15.38Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
15.38Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
15.38Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
15.38Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
15.38Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
15.38Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.38Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.22Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
15.22Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
15.22Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
15.15Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
15.15Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
15.15Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
15.15Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.15Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.15Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
15.15Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
15.15Single8IW72-Phenylethylamine8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
15.15Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
15.15Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
15.15Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
15.15Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
15.15Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
15.15Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
15.15Single9LRCHistamine9LRC-H4-Histamine
15.15Single9LREHistamine9LRE-H4-Histamine-Gi1/β1/γ2
15.15Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
15.15Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
15.15Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
15.15Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
15.00Single4BUONeurotensin4BUO-NTS1-Neurotensin
15.00Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
15.00Single5X93K-87945X93-ETB-K-8794
15.00Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
15.00Single6H7LDobutamine6H7L-β1-Dobutamine
15.00Single6IBLArformoterol6IBL-β1-Arformoterol
15.00Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
15.00Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
15.00Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
15.00Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
15.00Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
15.00Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
15.00Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
15.00Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-SBI-553-chim(NtGi1-Go)/β1/γ2
15.00Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
15.00Single8JPFNeurotensin8JPF-NTS1-Neurotensin-SBI-553
15.00Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
15.00Single8XVJMacitentan8XVJ-ETA-Macitentan
15.00Single8XVUCXCL28XVU-CXCR2-CXCL2
15.00Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
15.00Single9CGJC6-Quino9CGJ-δ-C6-Quino-Gi1/β1/γ2
15.00Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
15.00Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
15.00Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
15.00Consensuscck_onOrthosteric Ligandccka_on cckb_on
15.00Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
15.00Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
15.00Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
15.00Consensuschemerin_onOrthosteric Ligandcml1_on
15.00Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
15.00Consensusendothelin_offOrthosteric Ligandetb_off
15.00Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
15.00Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.00Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.00Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
14.89Single8W8XBeta-MSH8W8X-MC3-β-MSH-Ca-Gs/β1/γ2
14.89Single9KDFRES-701-39KDF-ETB-RES-701-3
14.71Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
14.71Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
14.71Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
14.71Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
14.71Single8HSCFab0468HSC-GPR20-Fab046-Gi1/β1/γ2
14.71Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
14.71Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
14.71Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
14.71Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
14.71Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
14.71Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
14.71Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
14.71Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
14.71Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
14.71Single8YN7Immethridine8YN7-H3-Immethridine-Go/β1/γ2
14.71Single9EPRRetinal9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
14.71Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
14.71Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
14.63Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
14.63Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
14.63Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
14.63Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
14.63Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
14.63Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
14.63Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
14.63Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
14.63Single9CGKC5-Quino9CGK-δ-C5-Quino-Gi1/β1/γ2
14.63Single9CM7TUG-13759CM7-FFA2-TUG-1375-AZ-1729-Gi1/β1/γ2
14.63Single9IPVJR14a9IPV-C3aB-JR14a-Gi1/β1/γ2
14.63Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
14.63Single9NS9TUG-13759NS9-FFA2-TUG-1375-Compound 187-Gi1/β1/γ2
14.63Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
14.63Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
14.63Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
14.63Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
14.63Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
14.58Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
14.29Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
14.29Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
14.29Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
14.29Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
14.29Single4BWBNeurotensin4BWB-NTS1-Neurotensin
14.29Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
14.29Single6AKXA4R6AKX-CCR5-A4R
14.29Single6AKYMaraviroc6AKY-CCR5-Maraviroc
14.29Single6B73MP11046B73-κ-MP1104
14.29Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
14.29Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
14.29Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
14.29Single6ME2Ramelteon6ME2-MT1-Ramelteon
14.29Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
14.29Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
14.29Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
14.29Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
14.29Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
14.29Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
14.29Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
14.29Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
14.29Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
14.29Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
14.29Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
14.29Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
14.29Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
14.29Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
14.29Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
14.29Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
14.29Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
14.29Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
14.29Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
14.29Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
14.29Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
14.29Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
14.29Single8IEBA1LYA8IEB-GPR156-A1LYA
14.29Single8IEIA1LYA8IEI-GPR156-A1LYA
14.29Single8IEPA1LYA8IEP-GPR156-A1LYA
14.29Single8IEPA1LYA8IEP-GPR156-A1LYA
14.29Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
14.29Single8KIGSHU91198KIG-MC3-SHU9119-Ca
14.29Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
14.29Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
14.29Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
14.29Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
14.29Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.29Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
14.29Single8WKYPG-9348WKY-MC4-PG-934
14.29Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
14.29Single8XWNCXCL88XWN-CXCR2-CXCL8
14.29Single8Y0HVUF114188Y0H-CXCR3-VUF11418
14.29Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go/β1/γ2
14.29Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ2
14.29Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
14.29Single8YYWAlpha-ketoglutarate8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
14.29Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
14.29Single9EEAAdenosine9EEA-A2A-Adenosine-Gs/β1/γ2
14.29Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
14.29Single9HB3Mambaquaretin-19HB3-V2-Mambaquaretin-1
14.29Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
14.29Single9KPESA09KPE-TAS2R16-SA0-Gi1/β1/γ2
14.29Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
14.29Consensusalpha2_offOrthosteric Ligandalpha2c_off
14.29Consensusangiotensin_offOrthosteric Ligandat1_off
14.29Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
14.29Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
14.29Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
14.29Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
14.29Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
14.29Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
14.29Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
14.29Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
14.29Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
14.29Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
14.29Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
14.29Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
14.29Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
14.29Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
14.29Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
14.29Consensussomatostatin_offOrthosteric Ligandsst2_off
14.00Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
13.95Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
13.95Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
13.95Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
13.95Single8IEBA1LYA8IEB-GPR156-A1LYA
13.95Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
13.95Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
13.95Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
13.95Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
13.89Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
13.89Single3REYXAC3REY-A2A-XAC
13.89Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
13.89Single4MBSMaraviroc4MBS-CCR5-Maraviroc
13.89Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
13.89Single4ZJCSB-6740424ZJC-OX1-SB-674042
13.89Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
13.89Single5IU7Q274563465IU7-A2A-Q27456346-Na
13.89Single5IUBQ274563445IUB-A2A-Q27456344-Na
13.89Single5JTBZM-2413855JTB-A2A-ZM-241385
13.89Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
13.89Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
13.89Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
13.89Single6AQFZM-2413856AQF-A2A-ZM-241385
13.89Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
13.89Single6KUXRS-799486KUX-α2a-RS-79948
13.89Single6MH8ZM-2413856MH8-A2A-ZM-241385
13.89Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
13.89Single6PS5S-Propranolol6PS5-β2-S-Propranolol
13.89Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
13.89Single6TPGEMPA6TPG-OX2-EMPA
13.89Single6VI4JDTic6VI4-κ-JDTic
13.89Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
13.89Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
13.89Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
13.89Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
13.89Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
13.89Single7AROLUF58337ARO-A2A-LUF5833-Na
13.89Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
13.89Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
13.89Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
13.89Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
13.89Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
13.89Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
13.89Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
13.89Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
13.89Single7F61PF-036547467F61-H3-PF-03654746
13.89Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.89Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.89Single7T32ZM-2413857T32-A2A-ZM-241385
13.89Single7T94Acetylcholine7T94-M2-Acetylcholine-LY2119620-chim(NtGi1-Go)/β1/γ2
13.89Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
13.89Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
13.89Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
13.89Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
13.89Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
13.89Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.89Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
13.89Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
13.89Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
13.89Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
13.89Single8IHKAcifran8IHK-HCA3-Acifran
13.89Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
13.89Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
13.89Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
13.89Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
13.89Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
13.89Single8K9LDamgo8K9L-μ-Damgo-BMS-986122-Gi3/β1/γ1
13.89Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
13.89Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
13.89Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
13.89Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
13.89Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.89Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.89Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
13.89Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.89Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.89Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.89Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.89Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
13.89Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
13.89Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
13.89Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
13.89Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
13.89Single8ZPNAMD31008ZPN-CXCR4-AMD3100
13.89Single9ARXSerotonin9ARX-5-HT2A-Serotonin
13.89Single9AS5Mescaline9AS5-5-HT2A-Mescaline
13.89Single9AS6Mescaline9AS6-5-HT2A-Mescaline-chim(NtGi1-Gs-CtGq)/β1/γ2
13.89Single9JFUNE52-QQ579JFU-GPR4-NE52-QQ57
13.89Single9JH3CMF-0199JH3-Apelin-CMF-019-Gi1/β1/γ2
13.89Single9JMDAzithromycin9JMD-Motilin-Azithromycin-chim(Gs-CtGq)/β1/γ2
13.89Single9K0XATP9K0X-P2Y2-ATP-chim(NtGi1-Gs-CtGq)/β1/γ2
13.89Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Gi1/β1/γ2
13.89Single9K20ATP9K20-P2Y2-ATP-chim(NtGi1-Go)/β1/γ2
13.89Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
13.89Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
13.89Consensusa2_offOrthosteric Liganda2a_off
13.89Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
13.89Consensusalpha1_onOrthosteric Ligandalpha1a_on
13.89Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
13.89Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
13.89Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
13.89Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
13.89Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
13.89Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
13.89Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
13.89Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
13.64Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
13.64Single6W25SHU91196W25-MC4-SHU9119-Ca
13.64Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
13.64Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
13.64Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
13.64Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
13.64Single8W8YGamma-MSH8W8Y-MC3-γ-MSH-Ca-Gs/β1/γ2
13.64Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
13.64Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
13.64Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
13.64Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
13.64Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
13.64Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
13.64Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
13.64Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
13.51Single2Y01Dobutamine2Y01-β1-Dobutamine
13.51Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
13.51Single3EMLZM-2413853EML-A2A-ZM-241385
13.51Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
13.51Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
13.51Single4DAJTiotropium4DAJ-M3-Tiotropium
13.51Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
13.51Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
13.51Single4MQSIperoxo4MQS-M2-Iperoxo
13.51Single4U14Tiotropium4U14-M3-Tiotropium
13.51Single5DHHSB-6121115DHH-NOP-SB-612111
13.51Single5IU8Q274563475IU8-A2A-Q27456347-Na
13.51Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
13.51Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
13.51Single5TGZAM65385TGZ-CB1-AM6538
13.51Single5UENDU1725UEN-A1-DU172
13.51Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
13.51Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
13.51Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
13.51Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
13.51Single6DRXLisuride6DRX-5-HT2B-Lisuride
13.51Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
13.51Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
13.51Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
13.51Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
13.51Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/β1/γ2
13.51Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
13.51Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
13.51Single6S0LZM-2413856S0L-A2A-ZM-241385
13.51Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
13.51Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
13.51Single7BU7BI1671077BU7-β1-BI167107
13.51Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
13.51Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
13.51Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
13.51Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
13.51Single7PYRPSB-21157PYR-A2A-PSB-2115
13.51Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
13.51Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
13.51Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
13.51Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
13.51Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
13.51Single7WC7Lisuride7WC7-5-HT2A-Lisuride
13.51Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
13.51Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
13.51Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
13.51Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
13.51Single8CU6LJ-45178CU6-A2A-LJ-4517
13.51Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
13.51Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
13.51Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.51Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
13.51Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
13.51Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
13.51Single8JJOAlprenolol8JJO-β2-Alprenolol
13.51Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
13.51Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
13.51Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
13.51Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
13.51Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
13.51Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
13.51Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
13.51Single8X64Desloratadine8X64-H1-Desloratadine
13.51Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
13.51Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
13.51Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
13.51Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
13.51Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
13.51Single9JGKBalovaptan9JGK-5-HT2B-Balovaptan
13.51Single9PLNN-(5-methylnaphthalen-1-yl)pyridin-4-amine9PLN-α2a-N-(5-methylnaphthalen-1-yl)pyridin-4-amine
13.51Single9PLON-(5-methylnaphthalen-1-yl)pyridin-4-amine9PLO-α2a-N-(5-methylnaphthalen-1-yl)pyridin-4-amine-Go/β1/γ2
13.51Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
13.51Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
13.51Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
13.51Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
13.51Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
13.51Consensusalpha2_onOrthosteric Ligandalpha2b_on
13.51Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
13.51Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
13.51Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
13.51Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
13.51Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
13.51Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
13.51Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
13.33Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
13.33Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
13.33Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
13.33Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
13.16Single2Y00Dobutamine2Y00-β1-Dobutamine
13.16Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
13.16Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
13.16Single5IUAQ274563485IUA-A2A-Q27456348-Na
13.16Single5N2RPSB-365N2R-A2A-PSB-36-Na
13.16Single5N2SPSB365N2S-A1-PSB36
13.16Single5WQCEMPA5WQC-OX2-EMPA
13.16Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
13.16Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
13.16Single6D26Fevipiprant6D26-DP2-Fevipiprant
13.16Single6E67BI1671076E67-β2-BI167107-Gs(CT)
13.16Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
13.16Single6S0QZM-2413856S0Q-A2A-ZM-241385
13.16Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
13.16Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
13.16Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
13.16Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
13.16Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
13.16Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.16Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
13.16Single8GNEKW-63568GNE-A2A-KW-6356-Na
13.16Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
13.16Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
13.16Single8QOTNanobody-E8QOT-μ-Nanobody-E
13.16Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
13.16Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
13.16Single8ZYTNeurotensin peptide 8-138ZYT-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
13.16Single9F34FOB02-04A9F34-D3-FOB02-04A-Go/β1/γ2
13.16Single9HAPTolvaptan9HAP-V2-Tolvaptan
13.16Single9HC04YI9HC0-mGlu5-4YI
13.16Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
13.16Single9K07DSO-5a9K07-BB3-DSO-5a-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.16Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
13.16Consensusadenosine_offOrthosteric Liganda1_off a2_off
13.16Consensusadgrg2_onOrthosteric Ligand7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
13.16Consensusadgrg2_on_gpOrthosteric Ligand7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
13.16Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
13.16Consensusblt_offOrthosteric Ligandblt1_off
13.16Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
13.16Consensusdp_offOrthosteric Liganddp2_off
13.16Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
13.16Consensusep_offOrthosteric Ligandep4_off
13.16Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
13.16Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
12.82Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
12.82Single4BV0Neurotensin4BV0-NTS1-Neurotensin
12.82Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
12.82Single5TZRMK86665TZR-FFA1-MK8666
12.82Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
12.82Single6TQ7SB-3348676TQ7-OX1-SB-334867
12.82Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
12.82Single7B6WCyclazosin7B6W-α1b-Cyclazosin
12.82Single7F1TMIP-1a7F1T-CCR5-MIP-1a
12.82Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
12.82Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
12.82Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
12.82Single7PX4PSB-21137PX4-A2A-PSB-2113
12.82Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
12.82Single7T9NDPPC7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
12.82Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
12.82Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.82Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.82Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
12.82Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.82Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
12.82Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
12.82Single8JD5JNJ-40411813; ADX881788JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
12.82Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
12.82Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
12.82Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
12.82Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
12.82Single8ZWFJR14a8ZWF-C3aB-JR14a
12.82Single9CLWTUG-13759CLW-FFA2-TUG-1375-4-CMTB-chim(NtGi1L-Gs-CtGq)/β1/γ2
12.82Consensusneurotensin_onOrthosteric Ligandnts1_on
12.82Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
12.82Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
12.82Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
12.82Consensustachykinin_offOrthosteric Ligandnk1_off
12.50Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
12.50Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
12.50Single4N4WSANT-14N4W-SMO-SANT-1
12.50Single6CM4Risperidone6CM4-D2-Risperidone
12.50Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
12.50Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
12.50Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
12.50Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
12.50Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
12.50Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
12.50Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
12.50Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
12.50Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
12.50Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
12.50Single8W8WAlpha-MSH8W8W-MC3-α-MSH-Ca-Gs/β1/γ2
12.50Single8XWMCXCL68XWM-CXCR2-CXCL6
12.50Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
12.50Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
12.50Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
12.50Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
12.50Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
12.50Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
12.50Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
12.50Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
12.50Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
12.50Consensusorexin_onOrthosteric Ligandox2_on
12.24Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
12.20Single5CGDHTL142425CGD-mGlu5-HTL14242
12.20Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
12.20Single8XWFCXCL38XWF-CXCR2-CXCL3
12.20Single8ZPLHF511168ZPL-CXCR4-HF51116
12.20Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
12.20Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
12.20Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
12.12Single3RFMCaffeine3RFM-A2A-Caffeine
12.12Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
12.12Single8A2OTheophylline8A2O-A2A-Theophylline-Na
12.12Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.12Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
12.12Single8IWM2-Phenylethylamine8IWM-TA9-2-Phenylethylamine
12.12Single8Y02Retinal8Y02-OPN1SW-Retinal-Gi1/β1/γ2
12.12Single9IVMLSN33188399IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
11.90Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
11.90Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
11.90Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.90Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
11.90Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
11.90Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
11.90Single9IPYJR14a9IPY-C3aB-JR14a
11.90Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
11.90Consensuskisspeptin_onOrthosteric Ligandkiss1_on
11.76Single3UZAGTPL92363UZA-A2A-GTPL9236
11.76Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
11.76Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
11.76Single6ME5Agomelatine6ME5-MT1-Agomelatine
11.76Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
11.76Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
11.76Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
11.76Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
11.76Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
11.76Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
11.76Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
11.76Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
11.76Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
11.76Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
11.76Consensus5ht2_onOrthosteric Ligand5ht2b_on
11.76Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.76Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
11.76Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
11.76Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
11.63Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
11.63Single8IEIA1LYA8IEI-GPR156-A1LYA
11.63Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
11.63Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
11.63Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
11.63Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
11.63Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
11.63Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
11.63Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
11.43Single3OE9IT1t3OE9-CXCR4-IT1t
11.43Single3PBLEticlopride3PBL-D3-Eticlopride
11.43Single6HLLCP999946HLL-NK1-CP99994
11.43Single6LI0C176LI0-GPR52-C17
11.43Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
11.43Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
11.43Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
11.43Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
11.43Single7SRQLSD7SRQ-5-HT2B-LSD
11.43Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
11.43Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
11.43Single7V68Iperoxo7V68-M4-Iperoxo-LY2119620-Gi1/β1/γ2
11.43Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
11.43Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
11.43Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
11.43Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.43Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
11.43Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
11.43Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab
11.43Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
11.43Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
11.43Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
11.43Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
11.43Single9AS7Psilocin9AS7-5-HT2A-Psilocin
11.43Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
11.43Single9IXJHistamine9IXJ-H2-Histamine-Gs/β1/γ2
11.43Single9IZDCHBA9IZD-HCA1-CHBA-Gi1/β1/γ2
11.43Single9LMPNE52-QQ579LMP-GPR4-NE52-QQ57
11.43Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
11.43Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
11.43Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
11.43Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
11.36Single7SK5CXCL127SK5-ACKR3-CXCL12
11.36Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
11.36Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
11.11Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
11.11Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
11.11Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
11.11Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
11.11Single4S0VSuvorexant4S0V-OX2-Suvorexant
11.11Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
11.11Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
11.11Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
11.11Single5U09Taranabant5U09-CB1-Taranabant
11.11Single5WS3EMPA5WS3-OX2-EMPA
11.11Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
11.11Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
11.11Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
11.11Single6TODEMPA6TOD-OX1-EMPA-Na
11.11Single6TPJSuvorexant6TPJ-OX2-Suvorexant
11.11Single7BR3Elagolix7BR3-GnRH1-Elagolix
11.11Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
11.11Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.11Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
11.11Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
11.11Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
11.11Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
11.11Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.11Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.11Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
11.11Single8GNGIstradefylline8GNG-A2A-Istradefylline
11.11Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
11.11Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
11.11Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
11.11Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
11.11Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.11Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.11Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
11.11Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
11.11Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
11.11Single8YYWAlpha-ketoglutarate8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
11.11Single9H2XA1IR19H2X-A2A-A1IR1-Na
11.11Single9K6LSA09K6L-TAS2R16-SA0-Gi2/β1/γ2
11.11Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
11.11Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
11.11Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.11Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
11.11Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
11.11Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
11.11Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
11.11Consensusorexin_offOrthosteric Ligandox2_off ox1_off
11.11Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
11.11Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
11.11Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
10.87Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
10.81Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
10.81Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
10.81Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
10.81Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
10.81Single5UVIZM-2413855UVI-A2A-ZM-241385
10.81Single6A94Zotepine6A94-5-HT2A-Zotepine
10.81Single6FFIMMPEP6FFI-mGlu5-MMPEP
10.81Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
10.81Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
10.81Single6TP3Nemorexant6TP3-OX1-Nemorexant
10.81Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
10.81Single6V9SGTPL114036V9S-OX1-GTPL11403
10.81Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
10.81Single6ZG9GSK10347026ZG9-M1-GSK1034702
10.81Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
10.81Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
10.81Single7T94LY21196207T94-M2-Acetylcholine-LY2119620-chim(NtGi1-Go)/β1/γ2
10.81Single7VV6C48/807VV6-MRGPRX2-C48/80
10.81Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
10.81Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
10.81Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
10.81Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
10.81Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
10.81Single8K2WAMG4878K2W-CXCR3-AMG487
10.81Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
10.81Single8RLNLUF58348RLN-A2A-LUF5834
10.81Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
10.81Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
10.81Single8Y6YGLPG09748Y6Y-FFA2-GLPG0974
10.81Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
10.81Single8ZPMAMD0708ZPM-CXCR4-AMD070
10.81Single9AS3LSD9AS3-5-HT2A-LSD
10.81Single9AS4LSD9AS4-5-HT2A-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
10.81Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
10.81Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
10.81Single9IXXLTD49IXX-CysLT2-LTD4-chim(NtGi1-Gs-CtGq)/β1/γ2
10.81Single9KPDSA09KPD-TAS2R16-SA0-chim(Gs-CtGt3)/β1/γ2
10.81Single9LRDHistamine9LRD-H1-Histamine-Gi1/β1/γ2
10.81Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
10.81Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
10.81Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
10.81Consensusgrh_offOrthosteric Ligandgnrh1_off
10.81Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
10.81Consensusopsins_offOrthosteric Ligandrhodopsin_off
10.81Consensussensory_offOrthosteric Ligandopsins_off
10.64Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.53Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
10.53Single2Y02Carmoterol2Y02-β1-Carmoterol
10.53Single4QIMANTA XV4QIM-SMO-ANTA XV
10.53Single5DHGC-355DHG-NOP-C-35
10.53Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
10.53Single5T04Neurotensin5T04-NTS1-Neurotensin
10.53Single6D27CAY104716D27-DP2-CAY10471
10.53Single6FFHFenobam6FFH-mGlu5-Fenobam
10.53Single6GPSMK08126GPS-CCR2-MK0812
10.53Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
10.53Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
10.53Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
10.53Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
10.53Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
10.53Single7YXAONO-54306087YXA-S1P5-ONO-5430608
10.53Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
10.53Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
10.53Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
10.53Single8X63Mepyramine8X63-H1-Mepyramine
10.53Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
10.53Single8ZYYNeurotensin peptide 8-138ZYY-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
10.53Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
10.53Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
10.53Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
10.53Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
10.53Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
10.53Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
10.53Consensushistamine_offOrthosteric Ligandh1_off
10.42Single7SK3CXCL127SK3-ACKR3-CXCL12
10.26Single4JKVTaladegib4JKV-SMO-Taladegib
10.26Single5CGCHTL142425CGC-mGlu5-HTL14242
10.26Single5XPRBosentan5XPR-ETB-Bosentan
10.26Single6GPXMK08126GPX-CCR2-MK0812
10.26Single6HLPNetupitant6HLP-NK1-Netupitant
10.26Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
10.26Single6LUQHaloperidol6LUQ-D2-Haloperidol
10.26Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
10.26Single7W41PD1762527W41-BB2-PD176252
10.26Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
10.26Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
10.26Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
10.26Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
10.26Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
10.26Single8ZVZBW245C8ZVZ-DP1-BW245C-Gs/β1/γ2
10.26Single9B9ZA1AKO9B9Z-CB1-A1AKO
10.26Single9KPFSA09KPF-TAS2R16-SA0-Gi1/β1/γ2
10.26Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
10.26Consensusbombesin_offOrthosteric Ligandbb2_off
10.26Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
10.00Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
10.00Single5V56TC1145V56-SMO-TC114
10.00Single5V57TC1145V57-SMO-TC114
10.00Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
10.00Single6J20Aprepitant6J20-NK1-Aprepitant
10.00Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
10.00Single7R0CAVP7R0C-V2-AVP-Arrestin2
10.00Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
10.00Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
10.00Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
10.00Single8XVLZibotentan8XVL-ETA-Zibotentan
10.00Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
10.00Single8ZW0PGD28ZW0-DP1-PGD2-Gs/β1/γ2
10.00Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
9.76Single5X33BIIL2605X33-BLT1-BIIL260
9.76Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
9.76Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
9.76Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
9.76Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.76Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
9.76Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
9.76Single8XJNCloprosetnol8XJN-TXA2-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
9.76Single8XQJJN2418XQJ-Apelin-JN241
9.76Single8XWACXCL18XWA-CXCR2-CXCL1
9.76Single8XWSCXCL58XWS-CXCR2-CXCL5
9.76Single9AU0BW245C9AU0-DP1-BW245C-Gs/β1/γ2
9.76Single9BJKNAM9BJK-μ-Naloxone-NAM
9.76Single9GGGI-BOP9GGG-TXA2-I-BOP-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.52Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
9.52Single6K1QIRL25006K1Q-ETB-IRL2500
9.52Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
9.52Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
9.52Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
9.52Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
9.52Single8T3OTUG-8918T3O-FFA4-TUG-891-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.52Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
9.52Single8XJOU466198XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
9.52Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
9.52Single9M1HProstaglandin E29M1H-EP1-Prostaglandin E2-chim(NtGi1-Gs-CtGq)/β1/γ2
9.52Consensusfp-alpha_onOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
9.52Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
9.52Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
9.52Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
9.52Consensustp_onOrthosteric Ligand8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
9.52Consensustp_on_gpOrthosteric Ligand8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
9.38Single8GEJConstrained Epinephrine8GEJ-β2-Constrained Epinephrine-Gs/β1/γ2
9.30Single6KNMJN241-96KNM-Apelin-JN241-9
9.30Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
9.30Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
9.30Single8XQJJN2418XQJ-Apelin-JN241
9.30Single9JF4PD1683689JF4-BB1-PD168368
9.09Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
9.09Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
9.09Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.09Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
9.09Single8HS2Fab0468HS2-GPR20-Fab046
9.09Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
9.09Single8PWNTheophylline8PWN-A2A-Theophylline
9.09Single8X9S5alpha-DHT8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
8.89Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
8.89Single9IQRMuscarinic toxin 39IQR-α2a-Muscarinic toxin 3
8.82Single2HPYAll-trans-Retinal2HPY-Rhodopsin-All-trans-Retinal
8.82Single6TQ9SB-4081246TQ9-OX1-SB-408124
8.82Single6XBM5LWE6XBM-SMO-5LWE-Gi1/β1/γ2
8.82Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
8.82Single8WC5Tetramethylammonium Ion8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
8.82Single9CHUNoradrenaline9CHU-β2-Noradrenaline
8.82Consensusgs_histamineOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
8.82Consensush2_onOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
8.82Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
8.82Consensusp2y_offOrthosteric Ligandp2y1_off
8.82Consensussensory_onOrthosteric Ligandopsins_on
8.57Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
8.57Single3OE6IT1t3OE6-CXCR4-IT1t
8.57Single3PQRAll-trans-Retinal3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
8.57Single4XNWMRS25004XNW-P2Y1-MRS2500
8.57Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
8.57Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
8.57Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
8.57Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.57Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
8.57Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
8.57Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
8.57Consensusgi_sensoryOrthosteric Ligandgi_opsins
8.57Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
8.57Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
8.57Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
8.57Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
8.33Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
8.33Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
8.33Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
8.33Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
8.33Single4O9RCyclopamine4O9R-SMO-Cyclopamine
8.33Single5L7IVismodegib5L7I-SMO-Vismodegib
8.33Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
8.33Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
8.33Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
8.33Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
8.33Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.33Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
8.33Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
8.33Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
8.33Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
8.33Single7XP6Strychnine7XP6-TAS2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
8.33Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
8.33Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
8.33Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
8.33Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
8.33Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
8.33Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.33Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
8.33Single8YN2Histamine8YN2-H1-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
8.33Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
8.33Single8ZYUNeurotensin peptide 8-138ZYU-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
8.33Single9AS2DMT9AS2-5-HT2A-DMT-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Single9B9Y7DY9B9Y-CB1-7DY
8.33Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
8.33Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
8.33Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg4_on
8.33Consensusadgrg_on_gpOrthosteric Ligandadgrg2_on_gp adgrg4_on_gp
8.33Consensusgq_nucleotideOrthosteric Ligandgq_p2y
8.33Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
8.11Single3ODUIT1t3ODU-CXCR4-IT1t
8.11Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
8.11Single4QINSAG1.54QIN-SMO-SAG1.5
8.11Single6DS0Ly2660976DS0-5-HT2B-Ly266097
8.11Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
8.11Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
8.11Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
8.11Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
8.11Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
8.11Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
8.11Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
8.11Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
8.11Single7VVOPTH7VVO-PTH1-PTH-Gs/β1/γ2
8.11Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
8.11Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
8.11Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
8.11Single7XRRLemborexant7XRR-OX2-Lemborexant
8.11Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
8.11Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
8.11Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
8.11Single8T3VDocosa-4,7,10,13,16,19-Hexaenoic acid8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.11Single8U4PAMD31008U4P-CXCR4-AMD3100-Gi1/β1/γ2
8.11Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
8.11Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
8.11Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
8.11Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
8.11Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
8.11Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
8.11Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
8.11Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
8.11Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
7.89Single3RZECidoxepin3RZE-H1-Cidoxepin
7.89Single6IQLL7458706IQL-D4-L745870
7.89Single6TPNHTL66416TPN-OX2-HTL6641
7.89Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
7.89Single7UTZDPPC7UTZ-TSH-TR1402-DPPC-Gs/β1/γ2
7.89Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
7.89Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
7.89Single8IYXYL-3658IYX-GPR34-YL-365
7.89Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
7.89Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.89Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
7.89Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
7.89Single8YRGFospropofol8YRG-MRGPRX4-Fospropofol-chim(NtGi1-Gs-CtGq)/β1/γ2
7.89Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
7.89Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
7.89Single9BA0A1AKN9BA0-CB1-A1AKN
7.89Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
7.89Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
7.89Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
7.69Single6IIVDaltroban6IIV-TXA2-Daltroban
7.69Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
7.69Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
7.69Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
7.69Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
7.69Single9IMATalquetamab9IMA-GPRC5D-Talquetamab
7.50Single5T1ABMS-6815T1A-CCR2-BMS-681-PubChem 12093170
7.50Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
7.50Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
7.50Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
7.50Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
7.50Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
7.50Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
7.50Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
7.50Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
7.32Single6E59L-7607356E59-NK1-L-760735
7.32Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
7.32Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
7.32Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Gi1/β1/γ1
7.32Single8YNTSNAP-948478YNT-MCH1-SNAP-94847
7.14Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
7.14Single6IIURamatroban6IIU-TXA2-Ramatroban
7.14Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
6.98Single9GG5U466199GG5-TXA2-U46619-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.98Single9JH5C16:0 Ceramide9JH5-CysLT2-C16:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
6.82Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
6.45Consensusclass-b2_onOrthosteric Ligandadgrg_on adgrf_on adgrl_on adgre_on adgrd_on
6.45Consensusclass-b2_on_gpOrthosteric Ligandadgrg_on_gp adgrf_on_gp adgrl_on_gp adgre_on_gp adgrd_on_gp
6.06Single4A4MAll-trans-Retinal4A4M-Rhodopsin-All-trans-Retinal-Gt(CT)
6.06Single5EN0All-trans-Retinal5EN0-Rhodopsin-All-trans-Retinal-Gt(CT)
6.06Single5MZPCaffeine5MZP-A2A-Caffeine-Na
6.06Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
5.88Single3PXOAll-trans-Retinal3PXO-Rhodopsin-All-trans-Retinal
5.88Single5DYSAll-trans-Retinal5DYS-Rhodopsin-All-trans-Retinal
5.88Single6VCBLSN31604406VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
5.88Single7V68LY21196207V68-M4-Iperoxo-LY2119620-Gi1/β1/γ2
5.88Single7XKDBeta-Hydroxyandrosterone7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
5.71Single3OE8IT1t3OE8-CXCR4-IT1t
5.71Single6OY9All-trans-Retinal6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
5.71Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.71Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Gi1/β1/γ2
5.71Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
5.56Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
5.56Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
5.56Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
5.41Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
5.41Single7UL2SR486927UL2-NTS1-SR48692-Na
5.41Single9E7RGB889E7R-PAR2-GB88-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.41Consensusneurotensin_offOrthosteric Ligandnts1_off
5.41Consensusnts1_offOrthosteric Ligand7UL2-NTS1-SR48692-Na
5.26Single6C1QNDT95137276C1Q-C5a1-PMX53-NDT9513727
5.26Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
5.26Single7F8ULintitript7F8U-CCKA-Lintitript
5.26Single7F8YDevazepide7F8Y-CCKA-Devazepide
5.26Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
5.26Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
5.26Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.26Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
5.26Single9LRBHistamine9LRB-H1-Histamine-Gs/β1/γ2
5.13Single6TPKRetosiban6TPK-OT-Retosiban
5.13Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ2
5.13Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
5.13Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
5.13Consensusvasop-oxy_offOrthosteric Ligandot_off
5.00Single7F83PF-051904577F83-Ghrelin-PF-05190457
5.00Single8TH3AT118-H Nanobody8TH3-AT1-AT118-H Nanobody
5.00Consensuscck_offOrthosteric Ligandccka_off
5.00Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
4.88Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
4.88Single6Z4SSR486926Z4S-NTS1-SR48692
4.88Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Single8GDBPGE28GDB-EP4-PGE2-Gs/β1/γ2
4.55Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
4.35Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
3.23Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
3.23Single6D35Cholesterol6D35-SMO-Cholesterol
3.23Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
3.23Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
3.23Single6UO8SKF975416UO8-GABAB1, GABAB2-SKF97541-GS39783
3.23Single6UO9SKF975416UO9-GABAB1, GABAB2-SKF97541
3.23Single6W2XPubChem 53110426W2X-GABAB1, GABAB2-PubChem 5311042
3.23Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042
3.23Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042
3.23Single7C7QBaclofen7C7Q-GABAB1, GABAB2-Baclofen-BHFF
3.23Single7C7SCGP546267C7S-GABAB1, GABAB2-CGP54626
3.23Single7CUMCGP546267CUM-GABAB1, GABAB2-CGP54626
3.23Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
3.23Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
3.23Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
3.23Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
3.23Single7DGEQuisqualate7DGE-mGlu1; mGlu1-Quisqualate
3.23Single7DTTCa7DTT-CaS-Ca-Ca
3.23Single7DTTCa7DTT-CaS-Ca-Ca
3.23Single7DTUTryptophan7DTU-CaS-Tryptophan
3.23Single7DTUTryptophan7DTU-CaS-Tryptophan
3.23Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
3.23Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
3.23Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
3.23Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
3.23Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
3.23Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
3.23Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
3.23Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
3.23Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
3.23Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
3.23Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
3.23Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
3.23Single7EB2Baclofen7EB2-GABAB2; GABAB1-Baclofen-rac-BHFF-Gi1/β1/γ2
3.23Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
3.23Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
3.23Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
3.23Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
3.23Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
3.23Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
3.23Single7FIHhCG7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
3.23Single7FIIhCG7FII-LH-hCG-chim(NtGi1-Gs)/β1/γ2
3.23Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
3.23Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
3.23Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
3.23Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
3.23Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
3.23Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
3.23Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
3.23Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
3.23Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
3.23Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
3.23Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
3.23Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
3.23Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
3.23Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
3.23Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
3.23Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
3.23Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
3.23Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
3.23Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
3.23Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
3.23Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
3.23Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
3.23Single7T9NM22 Fab7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
3.23Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
3.23Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
3.23Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
3.23Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
3.23Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
3.23Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
3.23Single7XW6M22 Fab7XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
3.23Single7XW7K1-707XW7-TSH-K1-70
3.23Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
3.23Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
3.23Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
3.23Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
3.23Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
3.23Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
3.23Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
3.23Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
3.23Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
3.23Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
3.23Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
3.23Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
3.23Single8JD0Glutamate8JD0-mGlu2; mGlu3-Glutamate-NAM563
3.23Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
3.23Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
3.23Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
3.23Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
3.23Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
3.23Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
3.23Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
3.23Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
3.23Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
3.23Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
3.23Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
3.23Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
3.23Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
3.23Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
3.23Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
3.23Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
3.23Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
3.23Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
3.23Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
3.23Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
3.23Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
3.23Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
3.23Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
3.23Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
3.23Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
3.23Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
3.23Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
3.23Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
3.23Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
3.23Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
3.23Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
3.23Single8WG9(2S)-2-amino-4-phosphonobutanoic acid8WG9-mGlu4; mGlu2-(2S)-2-amino-4-phosphonobutanoic acid
3.23Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
3.23Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
3.23Single8WGCLY3792688WGC-mGlu4; mGlu2-LY379268
3.23Single8WGDWAG; WA68WGD-mGlu4; mGlu2-WAG; WA6
3.23Single8WGDWAG; WA68WGD-mGlu4; mGlu2-WAG; WA6
3.23Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
3.23Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
3.23Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.23Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.23Single8WVXNorrin8WVX-LGR4-Norrin
3.23Single8WVYNorrin8WVY-LGR4-Norrin
3.23Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
3.23Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
3.23Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
3.23Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
3.23Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
3.23Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
3.23Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
3.23Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
3.23Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
3.23Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
3.23Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
3.23Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
3.23Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
3.23Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
3.23Single8XUMR-spondin-28XUM-LGR4-R-spondin-2
3.23Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
3.23Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
3.23Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
3.23Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
3.23Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
3.23Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
3.23Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
3.23Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
3.23Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
3.23Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
3.23Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
3.23Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
3.23Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
3.23Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
3.23Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
3.23Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
3.23Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
3.23Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
3.23Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
3.23Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
3.23Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
3.23Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
3.23Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
3.23Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
3.23Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
3.23Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
3.23Single9KHHNorrin9KHH-LGR4-Norrin
3.23Single9S37NB219S37-LGR4-NB21
3.23Single9UTBSucralose9UTB-TAS1R2; TAS1R3-Sucralose
3.12Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
3.12Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
3.12Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
3.12Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
3.12Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
3.12Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
3.12Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
3.12Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
3.12Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
3.12Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
3.12Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
3.12Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
3.12Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
3.12Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
3.12Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
3.12Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
3.03Single7KNUCalcitonin gene-related peptide-17KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
3.03Single7T9MCS-17 Antibody7T9M-TSH-CS-17 Antibody
3.03Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
2.94Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
2.94Single7FIGhCG7FIG-LH-hCG-chim(NtGi1L-Gs)/β1/γ2
2.94Single7UTZTR14027UTZ-TSH-TR1402-DPPC-Gs/β1/γ2
2.94Single7XW5TSH7XW5-TSH-TSH-ML109-Gs/β1/γ2
2.94Single7ZI0Cholesterol7ZI0-SMO-SAG-Cholesterol
2.94Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
2.86Single5L7DCholesterol5L7D-SMO-Cholesterol
2.86Single7T9ITSH7T9I-TSH-TSH-Gs/β1/γ2
2.86Single7WC4Serotonin7WC4-5-HT2A-Serotonin
2.86Single8I2GGlycoprotein hormones alpha chain8I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
2.78Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
2.78Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
2.70Single6OBAGTPL110746OBA-β2-S-Alprenolol-GTPL11074
2.70Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
2.70Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/β1/γ2
2.70Single7WC5Psilocin7WC5-5-HT2A-Psilocin
2.70Single8J6QCompound 9n8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
2.70Single8JPSCCL78JPS-ACKR1-CCL7
2.70Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
2.70Single8WG8Peptide8WG8-Glucagon-Peptide-chim(NtGi1-Gs)/β1/γ2
2.63Single6TP4ACT-4622066TP4-OX1-ACT-462206
2.63Single7CKZMevidalen7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
2.63Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
2.63Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
2.63Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/β1/γ2
2.63Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
2.63Single8K9LBMS-9861228K9L-μ-Damgo-BMS-986122-Gi3/β1/γ1
2.63Single8YKDDehydroepiandrosterone8YKD-ADGRG2-Dehydroepiandrosterone-chim(NtGi1-Gs)/β1/γ2
2.56Single4K5YCP-3763954K5Y-CRF1-CP-376395
2.56Single4XNVBPTU4XNV-P2Y1-BPTU
2.56Single8Y72BMS-9861228Y72-μ-Peptide-BMS-986122-Gi1/β1/γ2
2.50Single5O9HNDT95137275O9H-C5a1-NDT9513727
2.50Single6ZINSR486926ZIN-NTS1-SR48692
2.50Single7VODCariprazine7VOD-5-HT2A-Cariprazine
2.50Single8JD6VU03647708JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
2.44Single4Z9GCP-3763954Z9G-CRF1-CP-376395
2.44Single6C1RAvacopan; Na6C1R-C5a1-PMX53-Avacopan; Na
2.44Single8GTIBMK-C2058GTI-CRF1-BMK-C205
2.38Single8GTGBMK-I1528GTG-CRF1-BMK-I152
2.38Single8YYXLeukotriene e48YYX-Oxoglutarate-Leukotriene e4-chim(Gi1-CtGq)/β1/γ2
2.38Single9CM7AZ-17299CM7-FFA2-TUG-1375-AZ-1729-Gi1/β1/γ2
2.38Single9IYBA1D5Q9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
2.33Single8JD5JNJ-40411813; ADX881788JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
2.33Single8XXVA1D5Q8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
2.27Single8GTMBMK-C2038GTM-CRF1-BMK-C203
2.17Single5TZYMK8666; AP85TZY-FFA1-MK8666; AP8
2.13Single8XFTR-spondin-28XFT-LGR4-R-spondin-2-ZNRF3
2.13Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-ZNRF3
2.04Single8WVUR-spondin-18WVU-LGR4-R-spondin-1-RNF43
2.04Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-ZNRF3
2.00Single8XFPR-spondin-28XFP-LGR4-R-spondin-2-ZNRF3
1.89Single8XFSR-spondin-28XFS-LGR4-R-spondin-2-ZNRF3

Consensus Members
Id Members
7F16 7F16-PTH2-TIP39-Gs/β1/γ2
Net Summary
Imin 1.68
Number of Linked Nodes 917
Number of Links 1339
Number of Hubs 294
Number of Links mediated by Hubs 1042
Number of Communities 11
Number of Nodes involved in Communities 426
Number of Links involved in Communities 738
Path Summary
Number Of Nodes in MetaPath 64
Number Of Links MetaPath 63
Number of Shortest Paths 2309586
Length Of Smallest Path 3
Average Path Length 25.5822
Length of Longest Path 55
Minimum Path Strength 1.345
Average Path Strength 5.9612
Maximum Path Strength 27.08
Minimum Path Correlation 0.7
Average Path Correlation 0.989733
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 3.33333
Average % Of Corr. Nodes 56.6411
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 60.3344
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following consensuses:
IdComponents
pth_on_gppth1_on_gp
pth2_on_gp



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