Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
11x51 4.2425404
2I1x50 7.1325438
32x40 6.5775439
42x50 6.432509
52x57 6.695408
6E1x50 6.52429727
7E1x52 5.3625406
83x25 5.755629
93x26 5.395426
103x35 6.646507
113x42 7.6025448
123x50 5.18333609
133x51 5.6875408
144x50 5.076549
15E2.F201 9.455424
16E2x50 6.6225429
175x36 6.8875405
185x39 4.43407
195x47 11.7925418
205x48 4.6575406
215x50 3.895409
225x58 4.746509
236x41 6.858508
246x44 9.2375409
256x47 4.3525408
266x48 9.32518
276x51 6.90333617
286x52 12.342517
297x35 6.9675405
307x38 7.045417
317x39 6.665617
327x42 6.514518
337x53 7.63409
347x56 4.28507
358x49 5.7075406
368x50 5.64857738
378x54 6.115407
388x57 5.01857735
39Lig 7.484671510
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
11x33 NT.V52 15.156118.39NoNo043
22x65 NT.V52 17.29654.47NoNo053
32x61 2x65 19.43052.77NoNo065
41x39 2x61 21.55825.71NoNo076
51x39 7x39 23.3644.7NoYes077
67x39 7x42 24.14057.72YesYes178
72x56 7x42 33.71225.05NoYes178
82x56 3x28 61.39153.68NoNo075
93x28 E1x50 58.05476.56NoYes057
10E1x50 E1x51 11.86035.4YesNo073
11E1x50 E1x52 13.53356.83YesYes076
122x64 7x39 12.85165.87NoYes067
131x35 2x64 14.88151.62NoNo066
141x32 1x35 11.91726.25NoNo046
152x57 7x39 13.00948.14YesYes087
161x56 8x57 12.56752.67NoYes075
171x56 8x50 13.77972.67NoYes078
187x53 8x50 43.32487.94YesYes098
197x49 7x53 53.81195.81NoYes099
202x50 7x49 63.07424.04YesNo099
212x46 2x50 77.18228.14NoYes099
222x46 3x42 78.03777.71NoYes098
233x42 4x50 80.08657.41YesYes489
243x35 4x50 85.45324.01YesYes079
253x34 3x35 88.58487.31NoYes067
263x34 4x57 90.11277.51NoNo068
273x33 4x57 90.86723.23NoNo068
283x33 Lig 1006.91NoYes060
293x32 Lig 30.28714.95NoYes180
302x56 3x32 29.49777.3NoNo178
317x42 Lig 51.3595.44YesYes180
321x50 2x50 11.34586.73NoYes099
331x53 8x54 11.78775.24NoYes097
344x38 I2x57 14.54681.49NoNo086
354x38 4x41 20.68699.18NoNo087
364x41 4x45 24.50677.18NoNo076
372x42 4x45 28.08034.96NoNo086
382x42 3x46 32.07377.54NoNo089
393x46 6x37 35.79882.85NoNo098
406x37 6x41 58.85668.53NoYes088
413x43 6x41 96.19286.09NoYes098
423x43 6x44 97.97017.31NoYes099
433x40 6x44 52.57447.54NoYes089
443x40 Lig 58.79984.96NoYes080
456x44 6x48 61.094810.02YesYes098
466x48 Lig 52.574411.88YesYes180
477x35 Lig 13.12624.78YesYes050
483x25 E1x50 16.84196.53YesYes297
493x33 4x61 19.1784.61NoNo066
503x47 6x41 21.52033.96NoYes088
513x47 5x57 19.50944.8NoNo086
523x50 6x37 23.41764.86YesNo098
533x50 5x65 14.36373.64YesNo098
545x58 6x41 11.80988.25YesYes098
553x51 5x57 17.54596.24YesNo086
563x54 5x65 12.54852.85NoNo098
573x51 3x55 10.16832.06YesNo086
584x61 5x39 15.80016.28NoYes067
595x47 Lig 11.25114.94YesYes180
606x40 7x49 11.06485.91NoNo089
616x44 7x45 16.409412.08YesNo099
626x47 7x45 14.35438.41YesNo089
636x51 7x34 10.32294.87YesNo174
647x38 7x39 27.00073.68YesYes177
657x38 Lig 21.946512.95YesYes170
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
2x563x327.31NoNo7821
2x567x425.051NoYes7821
7x35E1.Y11815.120YesNo5412
3x327x428.051NoYes8811
3x32Lig14.951NoYes8010
3x334x573.230NoNo6812
3x334x614.610NoNo6612
3x33Lig6.910NoYes6010
3x36Lig12.190NoYes6010
3x375x4615.030NoNo7712
3x37Lig4.270NoYes7010
3x405x503.390NoYes8912
3x406x447.540NoYes8912
3x40Lig4.960NoYes8010
E2.T206E2x514.760NoNo4421
E2x51Lig3.450NoYes4010
5x445x483.961NoYes7612
5x446x523.961NoYes7711
5x44Lig5.221NoYes7010
5x475x484.291YesYes8612
5x475x513.651YesNo8612
5x476x5234.291YesYes8711
5x47Lig4.941YesYes8010
6x446x4810.020YesYes9821
6x486x517.021YesYes8711
6x486x525.011YesYes8711
6x487x4112.671YesNo8712
6x48Lig11.881YesYes8010
6x516x528.571YesYes7711
6x516x557.251YesNo7712
6x517x344.871YesNo7412
6x517x385.241YesYes7711
6x51Lig8.471YesYes7010
6x52Lig9.881YesYes7010
6x557x345.491NoNo7422
7x317x356.570NoYes3521
7x35Lig4.780YesYes5010
7x387x393.681YesYes7712
7x387x426.311YesYes7811
7x38Lig12.951YesYes7010
7x397x427.721YesYes7821
7x42Lig5.441YesYes8010
E2.V202E2x513.210NoNo1421
5x43Lig1.980NoYes7010
5x425x431.760NoNo4721
7x327x351.40NoYes3521

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
73.33Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
64.71Single5V54Methiothepin5V54-5-HT1B-Methiothepin
64.71Consensus5ht1_offOrthosteric Ligand5ht1b_off
64.71Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
64.71Consensus5ht_offOrthosteric Ligand5ht2_off 5ht5_off 5ht1_off
62.50Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
61.11Single5CXVTiotropium5CXV-M1-Tiotropium
61.11Single6A93Risperidone6A93-5-HT2A-Risperidone
61.11Single7DFPSpiperone7DFP-D2-Spiperone
61.11Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
61.11Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
60.00Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
60.00Consensusalpha1_onOrthosteric Ligandalpha1a_on
60.00Consensusalpha1a_onOrthosteric Ligand7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
58.82Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
58.82Consensusgo_amineOrthosteric Ligandgo_adrenergic go_muscarinic go_5ht
58.82Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
58.82Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
56.25Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
56.25Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
56.25Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
56.25Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
56.25Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6WH4-5-HT2A-Methiothepin 7VOE-5-HT2A-Aripiprazole 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 6A93-5-HT2A-Risperidone
56.25Consensusgs_tarOrthosteric Ligand8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
55.56Single4U15Tiotropium4U15-M3-Tiotropium
55.56Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
55.56Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
55.56Single6OL9Tiotropium6OL9-M5-Tiotropium
55.56Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2
55.56Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
55.56Single7W6PW967W6P-α2a-W96-Go/&β;1/&γ;2
55.56Single7W7EW587W7E-α2a-W58-Go/&β;1/&γ;2
55.56Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/&β;1/&γ;2
55.56Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/&β;1/&γ;2
55.56Consensush1_offOrthosteric Ligand3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole 8X63-H1-Mepyramine 8X64-H1-Desloratadine
55.56Consensushistamine_offOrthosteric Ligandh1_off
55.56Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl Scopolamine 5ZHP-M3-PubChem 134828589
55.56Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
55.56Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
55.00Single7SK9CCX6627SK9-ACKR3-CCX662
55.00Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
55.00Single8X5YAstemizole8X5Y-H1-Astemizole
53.33Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
53.33Single2G87All-trans-retinal2G87-Rhodopsin-All-trans-retinal
53.33Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
53.33Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2
53.33Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
53.33Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/&β;1/&γ;2
52.94Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
52.94Single3NY8ICI 118-5513NY8-β2-ICI 118-551
52.94Single4GBR(S)-Carazolol4GBR-β2-(S)-Carazolol
52.94Single4U16N-Methyl Scopolamine4U16-M3-N-Methyl Scopolamine
52.94Single5JQH(S)-Carazolol5JQH-β2-(S)-Carazolol
52.94Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
52.94Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
52.94Single6PS0(S)-Carazolol6PS0-β2-(S)-Carazolol
52.94Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2
52.94Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2
52.94Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
52.94Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/&β;1/&γ;2
52.94Single8X64Desloratadine8X64-H1-Desloratadine
52.94Consensusalpha2_onOrthosteric Ligandalpha2a_on alpha2b_on
52.94Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
52.94Consensusamine_onOrthosteric Ligandadrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on
52.94Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
52.94Consensustar_onOrthosteric Ligandta1_on
52.63Single3D4STimolol Maleate3D4S-β2-Timolol Maleate
52.63Single4AMIBucindolol4AMI-β1-Bucindolol
52.63Single6CM4Risperidone6CM4-D2-Risperidone
52.63Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
52.63Single6H7N(S)-Xamoterol6H7N-β1-(S)-Xamoterol
52.63Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
52.63Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
52.63Single7WCNAR2314537WCN-GPR119-AR231453-Gs/&β;1/&γ;2
52.63Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
52.63Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
52.38Single4IARErgotamine4IAR-5-HT1B-Ergotamine
52.17Single7C61Ergotamine7C61-5-HT1B-Ergotamine
50.00Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
50.00Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
50.00Single2RH1(S)-Carazolol2RH1-β2-(S)-Carazolol
50.00Single2YCW(S)-Carazolol2YCW-β1-(S)-Carazolol
50.00Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
50.00Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
50.00Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
50.00Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
50.00Single4WW3All-trans-retinal4WW3-Rhodopsin-All-trans-retinal
50.00Single5D6L(S)-Carazolol5D6L-β2-(S)-Carazolol
50.00Single5X7D(S)-Carazolol5X7D-β2-(S)-Carazolol-PubChem 129318963
50.00Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
50.00Single6IBLArformoterol6IBL-β1-Arformoterol
50.00Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
50.00Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
50.00Single6PS6Timolol6PS6-β2-Timolol
50.00Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
50.00Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2
50.00Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
50.00Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
50.00Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
50.00Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
50.00Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
50.00Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2
50.00Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
50.00Single7XJISolabegron7XJI-β3-Solabegron-Gs/&β;1/&γ;2
50.00Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2
50.00Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2
50.00Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
50.00Single8E9YPubChem 4466038E9Y-M3-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
50.00Single8EA0Iperoxo8EA0-M3-Iperoxo
50.00Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
50.00Single8GECEpinephrine8GEC-β2-Epinephrine-Gs/&β;1/&γ;2
50.00Single8GEFEpinephrine8GEF-β2-Epinephrine-Gs/&β;1/&γ;2
50.00Single8GGAEpinephrine8GGA-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
50.00Single8GGVEpinephrine8GGV-β2-Epinephrine
50.00Single8GGXEpinephrine8GGX-β2-Epinephrine
50.00Single8GH0Epinephrine8GH0-β2-Epinephrine
50.00Single8J19PubChem 1270454228J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
50.00Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
50.00Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
50.00Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
50.00Consensus5ht2_onOrthosteric Ligand5ht2a_on 5ht2c_on
50.00Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide 6DRX-5-HT2B-Lisuride
50.00Consensusalpha2a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
50.00Consensusamine_offOrthosteric Ligandadrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
50.00Consensusbeta1_off_alloOrthosteric Ligand4BVN-β1-Cyanopindolol-Na
50.00Consensusbeta2_offOrthosteric Ligand6PS2-β2-(S)-Alprenolol 6PS3-β2-(S)-Carvedilol 6PS5-β2-(S)-Propranolol 6PS6-β2-Timolol 2RH1-β2-(S)-Carazolol 6PS4-β2-ICI 118-551 3NY9-β2-PubChem 913103
50.00Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
50.00Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
50.00Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
50.00Consensusgs_muscarinicOrthosteric Ligand8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
50.00Consensusm2_offOrthosteric Ligand5ZKB-M2-AF-DX 384 5ZKC-M2-N-Methyl Scopolamine 5ZK3-M2-Quinuclidinyl benzilate hydrobromide
50.00Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
50.00Consensusopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
50.00Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
47.83Single5WF5UK-4320975WF5-A2A-UK-432097
47.62Single3NY9PubChem 9131033NY9-β2-PubChem 913103
47.62Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
47.37Single2YDVNECA2YDV-A2A-NECA
47.37Single3UONQuinuclidinyl benzilate hydrobromide3UON-M2-Quinuclidinyl benzilate hydrobromide
47.37Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
47.37Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
47.37Single4RWADIPP-NH24RWA-δ-DIPP-NH2
47.37Single4UHRCGS216804UHR-A2A-CGS21680
47.37Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
47.37Single5D5A(S)-Carazolol5D5A-β2-(S)-Carazolol
47.37Single5D5B(S)-Carazolol5D5B-β2-(S)-Carazolol
47.37Single5G53NECA5G53-A2A-NECA-Gs
47.37Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
47.37Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
47.37Single6WGTLSD6WGT-5-HT2A-LSD
47.37Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
47.37Single7EW7PubChem 40774607EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
47.37Single8G056-OAU8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
47.37Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
47.37Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
47.37Consensusangiotensin_offOrthosteric Ligandat1_off at2_off
47.37Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCZ-β1-Iodocyanopindolol
47.37Consensusdopamine_offOrthosteric Ligandd3_off d2_off d4_off
47.37Consensusgi_amineOrthosteric Ligandgi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
47.37Consensusgi_dopamineOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
47.37Consensusgo_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
47.37Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
47.06Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
47.06Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
47.06Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
47.06Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
47.06Single6PS4ICI 118-5516PS4-β2-ICI 118-551
47.06Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
47.06Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
47.06Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
47.06Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
47.06Single7F0TDopamine7F0T-D1-Dopamine-Gs/&β;1/&γ;2
47.06Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
47.06Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
47.06Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
47.06Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
47.06Single8GE1Epinephrine8GE1-β2-Epinephrine-Gs/&β;1/&γ;2
47.06Single8GE4Epinephrine8GE4-β2-Epinephrine-Gs/&β;1/&γ;2
47.06Single8GE6Epinephrine8GE6-β2-Epinephrine-Gs/&β;1/&γ;2
47.06Single8GE7Epinephrine8GE7-β2-Epinephrine-Gs/&β;1/&γ;2
47.06Single8GE8Epinephrine8GE8-β2-Epinephrine-Gs/&β;1/&γ;2
47.06Single8GE9Epinephrine8GE9-β2-Epinephrine-Gs/&β;1/&γ;2
47.06Single8GEGEpinephrine8GEG-β2-Epinephrine-Gs/&β;1/&γ;2
47.06Single8GFVEpinephrine8GFV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
47.06Single8GG4Epinephrine8GG4-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
47.06Single8GGIEpinephrine8GGI-β2-Epinephrine
47.06Single8GGQEpinephrine8GGQ-β2-Epinephrine
47.06Single8GGTEpinephrine8GGT-β2-Epinephrine
47.06Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
47.06Single8JLNT1AM8JLN-TA1-T1AM-Gs/&β;1/&γ;2
47.06Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2
47.06Single8UNQEpinephrine8UNQ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
47.06Single8UNZEpinephrine8UNZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
47.06Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/&β;1/&γ;2
47.06Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
47.06Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
47.06Consensus5ht2a_onOrthosteric Ligand7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
47.06Consensus5ht5_onOrthosteric Ligand5ht5a_on
47.06Consensus5ht5a_onOrthosteric Ligand7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
47.06Consensusalpha2b_onOrthosteric Ligand6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
47.06Consensusd3_onOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
47.06Consensusm1_off_alloOrthosteric Ligand6WJC-M1-Atropine-Muscarinic toxin 7
47.06Consensussensory_offOrthosteric Ligandopsin_off
46.67Single3PQRAll-trans-retinal3PQR-Rhodopsin-All-trans-retinal-Gt(CT)
46.67Single8POKHistamine8POK-H2-Histamine-Gs/&β;1/&γ;2
46.67Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
45.45Single4AMJ(S)-Carvedilol4AMJ-β1-(S)-Carvedilol
45.45Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
45.00Single4LDEBI1671074LDE-β2-BI167107
45.00Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
45.00Single6MXTSalmeterol6MXT-β2-Salmeterol
45.00Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
45.00Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/&β;1/&γ;2
45.00Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
45.00Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
45.00Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
45.00Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
45.00Single7YITNalfurafine7YIT-κ-Nalfurafine
45.00Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
45.00Single8JJ8Formoterol8JJ8-β2-Formoterol
45.00Single8JJLOlodaterol8JJL-β2-Olodaterol
45.00Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
45.00Consensusat2_offOrthosteric Ligand7JNI-AT2-Olodanrigan
45.00Consensusbeta1_onOrthosteric Ligand7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
45.00Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
45.00Consensusgo_5htOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
45.00Consensusgpr119_onOrthosteric Ligand7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
45.00Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
45.00Consensusopioid_offOrthosteric Ligandkop_off mop_off nop_off dop_off
45.00Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
44.44Single2Y01Dobutamine2Y01-β1-Dobutamine
44.44Single2Y04Salbutamol2Y04-β1-Salbutamol
44.44Single3NYA(S)-Alprenolol3NYA-β2-(S)-Alprenolol
44.44Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
44.44Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
44.44Single4DAJTiotropium4DAJ-M3-Tiotropium
44.44Single4EJ4Naltrindole4EJ4-δ-Naltrindole
44.44Single4MQSIperoxo4MQS-M2-Iperoxo
44.44Single4U14Tiotropium4U14-M3-Tiotropium
44.44Single4X1HNonyl Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
44.44Single5DSGTiotropium5DSG-M4-Tiotropium
44.44Single5YC8N-Methyl Scopolamine5YC8-M2-N-Methyl Scopolamine
44.44Single5ZK8N-Methyl Scopolamine5ZK8-M2-N-Methyl Scopolamine
44.44Single5ZKCN-Methyl Scopolamine5ZKC-M2-N-Methyl Scopolamine
44.44Single6DRXLisuride6DRX-5-HT2B-Lisuride
44.44Single6H7MSalbutamol6H7M-β1-Salbutamol
44.44Single6PS2(S)-Alprenolol6PS2-β2-(S)-Alprenolol
44.44Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
44.44Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
44.44Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
44.44Single7CRHSKF839597CRH-D1-SKF83959-Gs/&β;1/&γ;2
44.44Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
44.44Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
44.44Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
44.44Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
44.44Single7T2GMitragynine pseudoindoxyl7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
44.44Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
44.44Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
44.44Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/&β;1/&γ;2
44.44Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
44.44Single7VKTLTB47VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
44.44Single7WC7Lisuride7WC7-5-HT2A-Lisuride
44.44Single8GE3Epinephrine8GE3-β2-Epinephrine-Gs/&β;1/&γ;2
44.44Single8GEBEpinephrine8GEB-β2-Epinephrine-Gs/&β;1/&γ;2
44.44Single8GEEEpinephrine8GEE-β2-Epinephrine-Gs/&β;1/&γ;2
44.44Single8GEHEpinephrine8GEH-β2-Epinephrine-Gs/&β;1/&γ;2
44.44Single8GFWEpinephrine8GFW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
44.44Single8GFXEpinephrine8GFX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
44.44Single8GFYEpinephrine8GFY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
44.44Single8GFZEpinephrine8GFZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
44.44Single8GG0Epinephrine8GG0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
44.44Single8GG1Epinephrine8GG1-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
44.44Single8GG2Epinephrine8GG2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
44.44Single8GG6Epinephrine8GG6-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
44.44Single8GGJEpinephrine8GGJ-β2-Epinephrine
44.44Single8GGNEpinephrine8GGN-β2-Epinephrine
44.44Single8GGOEpinephrine8GGO-β2-Epinephrine
44.44Single8GGUEpinephrine8GGU-β2-Epinephrine
44.44Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2
44.44Single8J18(3R)-3-hydroxydodecanoic acid8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
44.44Single8JJOAlprenolol8JJO-β2-Alprenolol
44.44Single8JLZST19368JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
44.44Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
44.44Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
44.44Single8UNNEpinephrine8UNN-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
44.44Single8UNPEpinephrine8UNP-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
44.44Single8UO4Epinephrine8UO4-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
44.44Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
44.44Single8X63Mepyramine8X63-H1-Mepyramine
44.44Consensus5ht1a_onOrthosteric Ligand8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
44.44Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
44.44Consensusadrenergic_onOrthosteric Ligandbeta_on alpha_on
44.44Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
44.44Consensusblt_onOrthosteric Ligandblt1_on
44.44Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
44.44Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
44.44Consensusdopamine_onOrthosteric Ligandd3_on d2_on d5_on d1_on
44.44Consensusgi_5htOrthosteric Ligand7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
44.44Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
44.44Consensusgo_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
44.44Consensushistamine_onOrthosteric Ligandh1_on h4_on
44.44Consensusleuko_onOrthosteric Ligandblt_on
44.44Consensusm2_on_alloOrthosteric Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
44.44Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
44.44Consensusm4_on_alloOrthosteric Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
44.44Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
43.75Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
43.75Single3AYMAll-trans-retinal3AYM-Rhodopsin-All-trans-retinal
43.75Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
43.75Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
43.75Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
43.75Single8GEIEpinephrine8GEI-β2-Epinephrine-Gs/&β;1/&γ;2
43.75Single8GGSEpinephrine8GGS-β2-Epinephrine
43.75Single8GGYEpinephrine8GGY-β2-Epinephrine
43.75Single8ITFDMCHA8ITF-TAAR9-DMCHA-chim(NtGi1-Gs)/&β;1/&γ;2
43.75Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
43.75Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
43.75Single8UNVEpinephrine8UNV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
43.75Single8UNXEpinephrine8UNX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
43.75Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
43.75Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
43.75Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
43.75Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
43.48Single3QAKUK-4320973QAK-A2A-UK-432097
43.48Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
42.86Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
42.86Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
42.86Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
42.86Single6H7LDobutamine6H7L-β1-Dobutamine
42.86Single7EZCUKA7EZC-A2A-UKA
42.86Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
42.86Single7UM4AS26747237UM4-5-HT5A-AS2674723
42.86Single7XZ6APD6687XZ6-GPR119-APD668-Gs/&β;1/&γ;2
42.86Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
42.86Consensus5ht5a_offOrthosteric Ligand7UM4-5-HT5A-AS2674723
42.86Consensusendothelin_offOrthosteric Ligandetb_off
42.86Consensusetb_offOrthosteric Ligand5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500 5X93-ETB-K-8794
42.11Single2Y00Dobutamine2Y00-β1-Dobutamine
42.11Single2Y03Isoprenaline2Y03-β1-Isoprenaline
42.11Single5C1MBU725C1M-μ-BU72
42.11Single5TVNLSD5TVN-5-HT2B-LSD
42.11Single5ZK3Quinuclidinyl benzilate hydrobromide5ZK3-M2-Quinuclidinyl benzilate hydrobromide
42.11Single6E67BI1671076E67-β2-BI167107-Gs (fused)
42.11Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
42.11Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
42.11Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
42.11Single6PS3(S)-Carvedilol6PS3-β2-(S)-Carvedilol
42.11Single7BVQ(S)-Carazolol7BVQ-β1-(S)-Carazolol
42.11Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2
42.11Single7WC6LSD7WC6-5-HT2A-LSD
42.11Single7XKAEpinephrine7XKA-β2-Epinephrine
42.11Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
42.11Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
42.11Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
42.11Single8UNYEpinephrine8UNY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
42.11Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
42.11Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
42.11Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
42.11Consensusadrenergic_offOrthosteric Ligandbeta_off alpha_off
42.11Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
42.11Consensusbeta2_onOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
42.11Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
42.11Consensusgi_adrenergicOrthosteric Ligand7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
42.11Consensusgs_adrenergicOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJI-β3-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
41.67Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
41.18Single6KUXRS-799486KUX-α2a-RS-79948
41.18Single6OBA(S)-Alprenolol6OBA-β2-(S)-Alprenolol-GTPL11074
41.18Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
41.18Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/&β;1/&γ;2
41.18Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;1
41.18Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
41.18Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
41.18Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
41.18Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
41.18Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
41.18Single8A6CAll-trans-retinal8A6C-Rhodopsin-All-trans-retinal
41.18Single8A6DAll-trans-retinal8A6D-Rhodopsin-All-trans-retinal
41.18Single8A6EAll-trans-retinal8A6E-Rhodopsin-All-trans-retinal
41.18Single8GEAEpinephrine8GEA-β2-Epinephrine-Gs/&β;1/&γ;2
41.18Single8GG7Epinephrine8GG7-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
41.18Single8GG9Epinephrine8GG9-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
41.18Single8GGFEpinephrine8GGF-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
41.18Single8GGWEpinephrine8GGW-β2-Epinephrine
41.18Single8HOCImetit8HOC-H4-Imetit-Gi1/&β;1/&γ;2
41.18Single8UNOEpinephrine8UNO-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
41.18Single8UNWEpinephrine8UNW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
41.18Single8UO0Epinephrine8UO0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
41.18Single8UO3Epinephrine8UO3-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
41.18Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
41.18Consensus5ht2c_onOrthosteric Ligand8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
41.18Consensusalpha2a_offOrthosteric Ligand6KUX-α2a-RS-79948
41.18Consensusbeta2_off_alloOrthosteric Ligand6OBA-β2-(S)-Alprenolol-GTPL11074
41.18Consensusgi_histamineOrthosteric Ligand8HN8-H4-Histamine-Gi1/&β;1/&γ;2 8HOC-H4-Imetit-Gi1/&β;1/&γ;2
41.18Consensusgs_5htOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2 7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2 7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
41.18Consensusgs_histamineOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
41.18Consensush4_onOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
41.18Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
40.91Single4UG2CGS216804UG2-A2A-CGS21680
40.91Single5WF6UK-4320975WF6-A2A-UK-432097
40.91Single6PT3DPI-2876PT3-δ-DPI-287
40.74Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
40.00Single2HPYAll-trans-retinal2HPY-Rhodopsin-All-trans-retinal
40.00Single3P0GBI1671073P0G-β2-BI167107
40.00Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
40.00Single5X93K-87945X93-ETB-K-8794
40.00Single6H7JIsoprenaline6H7J-β1-Isoprenaline
40.00Single6J21Aprepitant6J21-NK1-Aprepitant
40.00Single6NI3BI1671076NI3-β2-BI167107-Gs/&β;1/&γ;2
40.00Single6TQ7SB-3348676TQ7-OX1-SB-334867
40.00Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2
40.00Single7EPENAM5637EPE-mGlu-NAM563
40.00Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2
40.00Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
40.00Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
40.00Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2
40.00Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
40.00Single8DZPmomSalB8DZP-κ-momSalB-Gi1/&β;1/&γ;2
40.00Single8E0GBU728E0G-μ-BU72
40.00Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
40.00Single8IWM2-Phenylethylamine8IWM-TAAR9-2-Phenylethylamine
40.00Single8JD0J9R8JD0-mGlu2; mGlu3-Glutamate-J9R
40.00Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
40.00Single8JXVClozapine8JXV-H4-Clozapine-Gi1/&β;1/&γ;2
40.00Single8JXWVUF68848JXW-H4-VUF6884-Gi1/&β;1/&γ;2
40.00Single8WC5Tetramethylammonium ion8WC5-TA1-Tetramethylammonium ion-chim(NtGi1-Gs)/&β;1/&γ;2
40.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
40.00Consensusa2_onOrthosteric Liganda2a_on a2b_on
40.00Consensusgi_muscarinicOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
40.00Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2
39.13Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
39.13Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
39.13Consensusmop_offOrthosteric Ligand7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
38.89Single3RZECidoxepin3RZE-H1-Cidoxepin
38.89Single4DKLBeta-funaltrexamine4DKL-μ-Beta-funaltrexamine
38.89Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
38.89Single5TE3Octyl Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
38.89Single6A94Zotepine6A94-5-HT2A-Zotepine
38.89Single6DS0Ly2660976DS0-5-HT2B-Ly266097
38.89Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
38.89Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
38.89Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
38.89Single6PS5(S)-Propranolol6PS5-β2-(S)-Propranolol
38.89Single6TPGEMPA6TPG-OX2-EMPA
38.89Single6TPNHTL66416TPN-OX2-HTL6641
38.89Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
38.89Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/&β;1/&γ;2
38.89Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
38.89Single7CMVPD1289077CMV-D3-PD128907-Gi1/&β;1/&γ;2
38.89Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2
38.89Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/&β;1/&γ;2
38.89Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
38.89Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
38.89Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2
38.89Single7VODCariprazine7VOD-5-HT2A-Cariprazine
38.89Single8GDZEpinephrine8GDZ-β2-Epinephrine-Gs/&β;1/&γ;2
38.89Single8GG3Epinephrine8GG3-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
38.89Single8GG5Epinephrine8GG5-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
38.89Single8GG8Epinephrine8GG8-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
38.89Single8GGKEpinephrine8GGK-β2-Epinephrine
38.89Single8GGMEpinephrine8GGM-β2-Epinephrine
38.89Single8GGPEpinephrine8GGP-β2-Epinephrine
38.89Single8UHBRO52563908UHB-TA1-RO5256390-Gs/&β;1/&γ;2
38.89Single8UNREpinephrine8UNR-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
38.89Single8UNSEpinephrine8UNS-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
38.89Single8UO2Epinephrine8UO2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
38.89Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
38.89Consensusd1_on_alloOrthosteric Ligand7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
38.89Consensusdop_off_alloOrthosteric Ligand4N6H-δ-Naltrindole-Na
38.89Consensush3_on_alloOrthosteric Ligand7F61-H3-PF-03654746-Cholesterol
38.46Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
38.10Single4N4WSANT-14N4W-SMO-SANT-1
38.10Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
38.10Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
38.10Single6ZG4HTL00099366ZG4-M1-HTL0009936
38.10Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/&β;1/&γ;2
38.10Single7XMTJ-21567XMT-SST4-J-2156-Gi1/&β;1/&γ;2
38.10Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
38.10Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
38.10Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/&β;1/&γ;2
38.10Consensusgi_class-fOther Ligandgi_frizzled
38.10Consensusgi_frizzledOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
38.10Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
38.10Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
37.50Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
37.50Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
37.50Single6FUFAll-trans-retinal6FUF-Rhodopsin-All-trans-retinal-Go/&β;1/&γ;2
37.50Single6HLOAprepitant6HLO-NK1-Aprepitant
37.50Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
37.50Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/&β;1/&γ;2
37.50Single7MT8All-trans-retinal7MT8-Rhodopsin-All-trans-retinal-GRK1
37.50Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
37.50Single8GGREpinephrine8GGR-β2-Epinephrine
37.50Single8GGZEpinephrine8GGZ-β2-Epinephrine
37.50Single8IW72-Phenylethylamine8IW7-TAAR9-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
37.50Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
37.50Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
37.50Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
37.50Consensusopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
36.84Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
36.84Single2Y02Carmoterol2Y02-β1-Carmoterol
36.84Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
36.84Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
36.84Single4QKXPubChem 762106284QKX-β2-PubChem 76210628
36.84Single6PRZ(S)-Alprenolol6PRZ-β2-(S)-Alprenolol
36.84Single6PS1Timolol6PS1-β2-Timolol
36.84Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
36.84Single7BU7BI1671077BU7-β1-BI167107
36.84Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
36.84Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
36.84Single7LJCPubChem 867641037LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
36.84Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
36.84Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
36.84Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
36.84Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
36.84Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
36.84Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
36.84Single8GGBEpinephrine8GGB-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
36.84Single8UNMEpinephrine8UNM-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
36.84Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
36.84Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
36.84Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
36.36Single5CGDHTL142425CGD-mGlu5-HTL14242
36.36Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
36.36Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
36.36Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
36.36Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
36.36Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/&β;1/&γ;2
36.36Single7XK2MK68927XK2-HCA2-MK6892-Gi1/&β;1/&γ;2
36.36Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
36.36Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
36.36Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
36.00Single6PT2KGCHM076PT2-δ-KGCHM07
36.00Consensusangiotensin_onOrthosteric Ligandat1_on
36.00Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
36.00Consensusgi_formylpeptideOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
35.29Single3PBLEticlopride3PBL-D3-Eticlopride
35.29Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
35.29Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
35.29Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
35.29Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
35.29Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
35.29Single7SRQLSD7SRQ-5-HT2B-LSD
35.29Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2
35.29Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2
35.29Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
35.29Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
35.29Single8EF6Morphine8EF6-μ-Morphine-Gi1/&β;1/&γ;2
35.29Single8GGCEpinephrine8GGC-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.29Single8GGEEpinephrine8GGE-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.29Single8HN8Histamine8HN8-H4-Histamine-Gi1/&β;1/&γ;2
35.29Single8IY9Niacin8IY9-HCA2-Niacin-Go/&β;1/&γ;2
35.29Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
35.29Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
35.29Consensusmt2_onOrthosteric Ligand7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
35.00Single5CGCHTL142425CGC-mGlu5-HTL14242
35.00Single5WIUNemonapride5WIU-D4-Nemonapride
35.00Single5WIVNemonapride5WIV-D4-Nemonapride-Na
35.00Single5WQCEMPA5WQC-OX2-EMPA
35.00Single5XPRBosentan5XPR-ETB-Bosentan
35.00Single6LUQHaloperidol6LUQ-D2-Haloperidol
35.00Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
35.00Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
35.00Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
35.00Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
35.00Single7SBFPZM217SBF-μ-PZM21-Gi1/&β;1/&γ;2
35.00Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
35.00Single8DZQmomSalB8DZQ-κ-momSalB-Go/&β;1/&γ;2
35.00Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2
35.00Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRR-D1-Rotigotine-Gs/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
35.00Consensusd4_offOrthosteric Ligand5WIU-D4-Nemonapride
35.00Consensusd4_off_alloOrthosteric Ligand5WIV-D4-Nemonapride-Na
35.00Consensusgo_opioidOrthosteric Ligand8DZQ-κ-momSalB-Go/&β;1/&γ;2
34.78Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
34.78Single7XY6PubChem 117178317XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
34.78Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
34.78Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
34.62Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
34.62Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
34.62Single8IHFMK68928IHF-HCA2-MK6892-Gi1/&β;1/&γ;2
34.62Single8J6IMK68928J6I-HCA2-MK6892-Gi1/&β;1/&γ;2
34.62Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
33.33Single2X72All-trans-retinal2X72-Rhodopsin-All-trans-retinal-Gt(CT)
33.33Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
33.33Single3PXOAll-trans-retinal3PXO-Rhodopsin-All-trans-retinal
33.33Single3SN6BI1671073SN6-β2-BI167107-Gs/&β;1/&γ;2
33.33Single4DJHJDTic4DJH-κ-JDTic
33.33Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
33.33Single5DYSAll-trans-retinal5DYS-Rhodopsin-All-trans-retinal
33.33Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
33.33Single6AKXA4R6AKX-CCR5-A4R
33.33Single6AKYMaraviroc6AKY-CCR5-Maraviroc
33.33Single6B73PubChem 1319551386B73-κ-PubChem 131955138
33.33Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
33.33Single6NWEOctyl Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
33.33Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
33.33Single6OYAAll-trans-retinal6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
33.33Single6TODEMPA6TOD-OX1-EMPA-Na
33.33Single7B6WCyclazosin7B6W-α1b-Cyclazosin
33.33Single7CKYPW04647CKY-D1-PW0464-Gs/&β;1/&γ;2
33.33Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
33.33Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2
33.33Single7JV5SKF812977JV5-D1-SKF81297-Gs/&β;1/&γ;2
33.33Single7JVPSKF839597JVP-D1-SKF83959-Gs/&β;1/&γ;2
33.33Single7KH0Acyclovir triphosphate7KH0-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
33.33Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
33.33Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
33.33Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
33.33Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
33.33Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
33.33Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
33.33Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
33.33Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2
33.33Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/&β;1/&γ;2
33.33Single8EFOPZM218EFO-μ-PZM21-Gi1/&β;1/&γ;2
33.33Single8GEDEpinephrine8GED-β2-Epinephrine-Gs/&β;1/&γ;2
33.33Single8IW4Spermidine8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Single8IWESpermidine8IWE-TAAR9-Spermidine
33.33Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/&β;1/&γ;2
33.33Single8J6RMK68928J6R-HCA2-MK6892-Gi1/&β;1/&γ;2
33.33Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
33.33Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
33.33Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
33.33Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
33.33Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
33.33Single8UNLEpinephrine8UNL-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8UNTEpinephrine8UNT-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8UNUEpinephrine8UNU-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8UO1Epinephrine8UO1-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
33.33Consensus5ht1b_onOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
33.33Consensus5ht5_offOrthosteric Ligand5ht5a_off
33.33Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
33.33Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
33.33Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Consensusalpha1b_offOrthosteric Ligand7B6W-α1b-Cyclazosin
33.33Consensusalpha2_offOrthosteric Ligandalpha2a_off alpha2c_off
33.33Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
33.33Consensusgi_nucleotideOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
33.33Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A2A-NECA-Gs/&β;1/&γ;1 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
33.33Consensusgt_class-aOrthosteric Ligandgt_opsin
33.33Consensusgt_opsinOrthosteric Ligandgt_sensory
33.33Consensusgt_sensoryOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
33.33Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
33.33Consensusmelatonin_onOrthosteric Ligandmt1_on mt2_on
33.33Consensusmglu_onOther Ligandmglu2_on mglu4_on
33.33Consensusnk1_offOrthosteric Ligand6J20-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
33.33Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
33.33Consensussst4_onOrthosteric Ligand7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
32.00Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
32.00Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
32.00Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
31.82Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
31.82Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
31.82Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
31.82Single6HLPNetupitant6HLP-NK1-Netupitant
31.82Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
31.82Single7K15MKD0467K15-BLT1-MKD046-Na
31.82Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
31.82Single8IJDMK68928IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
31.82Single8JWYPubChem 1684517108JWY-A2A-PubChem 168451710
31.82Single8JWZAB9288JWZ-A2A-AB928-Na
31.82Consensusblt1_offOrthosteric Ligand7K15-BLT1-MKD046-Na
31.82Consensusblt_offOrthosteric Ligandblt1_off
31.82Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
31.82Consensusleuko_offOrthosteric Ligandblt_off cyslt_off
31.82Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
31.58Single2YDOAdenosine2YDO-A2A-Adenosine
31.58Single3UZCPubChem 1355666093UZC-A2A-PubChem 135566609
31.58Single4MBSMaraviroc4MBS-CCR5-Maraviroc
31.58Single4ZJCSB-6740424ZJC-OX1-SB-674042
31.58Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
31.58Single6VI4JDTic6VI4-κ-JDTic
31.58Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
31.58Single7JOZVFP7JOZ-D1-VFP-Gs/&β;1/&γ;2
31.58Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
31.58Single7T32ZM2413857T32-A2A-ZM241385
31.58Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
31.58Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
31.58Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
31.58Single8GGLEpinephrine8GGL-β2-Epinephrine
31.58Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2
31.58Single8JERAcipimox8JER-HCA2-Acipimox-Go/&β;1/&γ;2
31.58Single8JHNMMF8JHN-HCA2-MMF-Go/&β;1/&γ;2
31.58Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
31.58Consensusgi_melatoninOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
31.58Consensushca_onOrthosteric Ligandhca2_on hca3_on
31.58Consensushcar_onOrthosteric Ligandhca_on
31.58Consensusox1_offOrthosteric Ligand6TOT-OX1-Lemborexant 6TP4-OX1-ACT-462206 6TP6-OX1-Filorexant 6V9S-OX1-GTPL11403 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ7-OX1-SB-334867 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant
31.58Consensusox2_offOrthosteric Ligand6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant
31.25Single6OY9All-trans-retinal6OY9-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
31.25Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
31.25Single7MTBAll-trans-retinal7MTB-Rhodopsin-All-trans-retinal-GRK1
31.25Consensussensory_onOrthosteric Ligandopsin_on
31.03Consensusendothelin_onOrthosteric Ligandetb_on eta_on
30.77Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
30.43Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
30.43Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
30.43Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
30.43Single6DDFDamgo6DDF-μ-Damgo-Gi1/&β;1/&γ;2
30.43Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
30.43Consensusbileacid_onOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
30.43Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
30.43Consensussteroid_onOrthosteric Ligandbileacid_on
30.00Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
30.00Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
30.00Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
30.00Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
30.00Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
30.00Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
30.00Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
30.00Single6IGLIRL16206IGL-ETB-IRL1620
30.00Single6TOTLemborexant6TOT-OX1-Lemborexant
30.00Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
30.00Single7SCGFH2107SCG-μ-FH210-Gi1/&β;1/&γ;2
30.00Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/&β;1/&γ;2
30.00Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
30.00Single7UL4Alvimopan7UL4-μ-Alvimopan
30.00Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
30.00Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
30.00Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
30.00Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
30.00Single8EFQDamgo8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
30.00Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
30.00Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
30.00Consensusadenosine_onOrthosteric Liganda1_on a2_on
30.00Consensusgi_hcaOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
30.00Consensusgi_hcarOrthosteric Ligandgi_hca
30.00Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
30.00Consensusgs_endothelinOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
30.00Consensushca2_onOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
30.00Consensushca3_onOrthosteric Ligand8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
30.00Consensusnucleotide_onOrthosteric Ligandadenosine_on
30.00Consensustachykinin_offOrthosteric Ligandnk1_off
29.63Single6JODAngiotensin II6JOD-AT2-Angiotensin II
29.63Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
29.63Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
29.63Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.63Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
29.41Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
29.41Single5WKTOctyl Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
29.41Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
29.41Single7MT9All-trans-retinal7MT9-Rhodopsin-All-trans-retinal-GRK1
29.41Single7MTAAll-trans-retinal7MTA-Rhodopsin-All-trans-retinal-GRK1
29.41Single7WC5Psilocin7WC5-5-HT2A-Psilocin
29.41Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/&β;1/&γ;2
29.41Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/&β;1/&γ;2
29.17Single5ZTYAM102575ZTY-CB2-AM10257
29.17Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
29.17Single7XN9L-054,5227XN9-SST2-L-054,522
29.17Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
29.17Consensusfpr2-alx_onOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
29.17Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
29.17Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
29.17Consensuslpl_offOrthosteric Ligands1p_off lpa_off
29.17Consensuslpl_onOrthosteric Ligands1p_on lpa_on
29.03Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
28.57Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
28.57Single5NM2ZM2413855NM2-A2A-ZM241385-Na
28.57Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
28.57Single6D26Fevipiprant6D26-DP2-Fevipiprant
28.57Single6DDEDamgo6DDE-μ-Damgo-Gi1/&β;1/&γ;2
28.57Single6GDGNECA6GDG-A2A-NECA-Gs/&β;1/&γ;1
28.57Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
28.57Single6TP6Filorexant6TP6-OX1-Filorexant
28.57Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
28.57Single7CKXA776367CKX-D1-A77636-Gs/&β;1/&γ;2
28.57Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
28.57Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
28.57Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
28.57Single7SINNPS-21437SIN-CaS-NPS-2143
28.57Single7SINNPS-21437SIN-CaS-NPS-2143
28.57Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
28.57Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
28.57Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
28.57Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
28.57Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
28.57Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
28.57Consensusa1_on_alloOrthosteric Ligand7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
28.57Consensusa2a_onOrthosteric Ligand6GDG-A2A-NECA-Gs/&β;1/&γ;1
28.57Consensusbk1_onOrthosteric Ligand7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.12Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
28.00Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
28.00Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.00Single8G59TUG-8918G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
28.00Consensusfpr-alx_onOrthosteric Ligandfpr1-alx_on fpr2-alx_on
28.00Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
28.00Consensussst_onOrthosteric Ligandsst2_on sst4_on
27.78Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
27.78Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
27.78Single6QNOAll-trans-retinal6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
27.78Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
27.78Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/&β;1/&γ;2
27.78Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/&β;1/&γ;2
27.78Single8GH1Epinephrine8GH1-β2-Epinephrine
27.78Single8JILNiacin8JIL-HCA2-Niacin-Gi1/&β;1/&γ;2
27.78Single8X2K5YM8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
27.78Consensus5ht4_onOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
27.78Consensusmt1_onOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
27.78Consensusox1_off_alloOrthosteric Ligand6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na 6TO7-OX1-Suvorexant-Na
27.59Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
27.59Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
27.27Single6E59L-7607356E59-NK1-L-760735
27.27Single6J20Aprepitant6J20-NK1-Aprepitant
27.27Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
27.27Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
27.27Single7P2L4YI7P2L-mGlu5-4YI
27.27Single7PX4PSB-21137PX4-A2A-PSB-2113
27.27Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
27.27Single7XTQR3997XTQ-GPBA-R399-Gs/&β;1/&γ;2
27.27Single8EFLSR170188EFL-μ-SR17018-Gi1/&β;1/&γ;2
27.27Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2
27.27Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
27.27Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2
27.27Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2
27.27Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/&β;1/&γ;2
27.27Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
27.27Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
27.27Consensusadenosine_offOrthosteric Liganda1_off a2_off
27.27Consensuslpa_offOrthosteric Ligandlpa1_off
27.27Consensusmglu2_onOther Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
27.27Consensuss1p2_onOrthosteric Ligand7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
26.92Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
26.92Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
26.92Consensusalpha1_offOrthosteric Ligandalpha1a_off alpha1b_off
26.67Single4A4MAll-trans-retinal4A4M-Rhodopsin-All-trans-retinal-Gt(CT)
26.67Single5EN0All-trans-retinal5EN0-Rhodopsin-All-trans-retinal-Gt(CT)
26.67Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.67Consensusetb_onOrthosteric Ligand8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
26.67Consensusgo_class-b1Orthosteric Ligandgo_crf
26.67Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
26.32Single5DHHSB-6121115DHH-NOP-SB-612111
26.32Single5WS3EMPA5WS3-OX2-EMPA
26.32Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
26.32Single6ME2Ramelteon6ME2-MT1-Ramelteon
26.32Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
26.32Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
26.32Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.32Single7TUZ7alpha,25-dihydroxycholesterol7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
26.32Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
26.32Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
26.32Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
26.32Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/&β;1/&γ;2
26.32Single8IHKAcifran8IHK-HCA3-Acifran
26.32Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2
26.32Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
26.32Single8U8FPML8U8F-GPR3-PML-Gs/&β;1/&γ;2
26.32Consensusorexin_offOrthosteric Ligandox2_off ox1_off
26.09Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
26.09Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
26.09Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.09Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
26.09Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
26.09Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.09Single8I95EP548I95-C3aB-EP54-Go/&β;1/&γ;2
26.09Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.09Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
26.09Single8WU1KCA8WU1-CB1-KCA-Arrestin1
26.09Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg3_on
26.09Consensusclass-b2_onOrthosteric Ligandadgrg_on
26.09Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
26.09Consensusdp_offOrthosteric Liganddp2_off
26.09Consensusgs_bileacidOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
26.09Consensusgs_steroidOrthosteric Ligandgs_bileacid
26.09Consensuspeptide_offOrthosteric Ligandopioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
25.93Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
25.93Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
25.93Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
25.93Consensusgi_chemerinOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
25.93Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
25.93Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
25.81Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
25.81Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
25.00Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
25.00Single5GLHEndothelin-15GLH-ETB-Endothelin-1
25.00Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
25.00Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
25.00Single6AQFZM2413856AQF-A2A-ZM241385
25.00Single6FFIMMPEP6FFI-mGlu5-MMPEP
25.00Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
25.00Single6IGKEndothelin-36IGK-ETB-Endothelin-3
25.00Single6IQLL7458706IQL-D4-L745870
25.00Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
25.00Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
25.00Single6ZG9GSK10347026ZG9-M1-GSK1034702
25.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
25.00Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
25.00Single7VVOPTH7VVO-PTH1-PTH-Gs/&β;1/&γ;2
25.00Single7WC4Serotonin7WC4-5-HT2A-Serotonin
25.00Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
25.00Single8GEJEpinephrine8GEJ-β2-Epinephrine-Gs/&β;1/&γ;2
25.00Single8GURPubChem 1048958GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2
25.00Single8ID8TUG-8918ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
25.00Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
25.00Single8JIMMMF8JIM-HCA2-MMF-Gi1/&β;1/&γ;2
25.00Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
25.00Single8K5CAcipimox8K5C-HCA2-Acipimox
25.00Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
25.00Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
25.00Consensusffa4_on_alloOrthosteric Ligand8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Consensusfpa_onOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Consensusgabab_offOther Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
25.00Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
25.00Consensusgi_somatostatinOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
25.00Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
25.00Consensusgs_orexinOrthosteric Ligand7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
25.00Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
25.00Consensusorexin_onOrthosteric Ligandox2_on
25.00Consensusot_onOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
25.00Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
25.00Consensuss1p_offOrthosteric Ligands1p1_off
24.24Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
24.14Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
24.14Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
24.14Consensusgs_bradykininOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
24.00Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
24.00Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
24.00Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
24.00Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
24.00Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
24.00Single8IYHMK68928IYH-HCA2-MK6892-Go/&β;1/&γ;2
24.00Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2 8I95-C3aB-EP54-Go/&β;1/&γ;2
24.00Consensusgo_vasopressinOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
24.00Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
23.81Single4EIYZM2413854EIY-A2A-ZM241385-Na
23.81Single5DHGPubChem 250014125DHG-NOP-PubChem 25001412
23.81Single5IU8Q274563475IU8-A2A-Q27456347-Na
23.81Single5OLGZM2413855OLG-A2A-ZM241385-Na
23.81Single5TGZAM65385TGZ-CB1-AM6538
23.81Single5UIGJ3.651.884G5UIG-A2A-J3.651.884G
23.81Single6D27CAY104716D27-DP2-CAY10471
23.81Single6FFHFenobam6FFH-mGlu5-Fenobam
23.81Single6GPSMK08126GPS-CCR2-MK0812
23.81Single7CFMP3957CFM-GPBA-P395-Gs/&β;1/&γ;2
23.81Single7PYRPSB-21157PYR-A2A-PSB-2115
23.81Single8CU6LJ-45178CU6-A2A-LJ-4517
23.81Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/&β;1/&γ;2
23.81Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/&β;1/&γ;2
23.81Single8K5DGSK2560738K5D-HCA2-GSK256073
23.81Consensusa2_offOrthosteric Liganda2a_off
23.81Consensusa2a_offOrthosteric Ligand8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 5UIG-A2A-J3.651.884G 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-PubChem 168451710 5K2D-A2A-ZM241385
23.81Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
23.81Consensusprostanoid_offOrthosteric Ligandep_off tp_off dp_off
23.53Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
23.53Consensushca2_on_alloOrthosteric Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
23.33Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
23.33Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
23.33Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.33Consensusbb1_onOrthosteric Ligand8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.33Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
23.33Consensusclass-d_onOrthosteric Ligandste2_on
23.08Single7F8XNN90567F8X-CCKA-NN9056
23.08Single7QA8Peptide7QA8-STE2-Peptide
23.08Single7QA8Peptide7QA8-STE2-Peptide
23.08Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
23.08Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
23.08Single8GHVPubChem 1459649038GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
23.08Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
23.08Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
23.08Consensusclass-d_offOrthosteric Ligandste2_off
23.08Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
23.08Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
23.08Consensussst2_onOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
22.73Single5IUAQ274563485IUA-A2A-Q27456348-Na
22.73Single5N2RPubChem 92460631; psb365N2R-A2A-PubChem 92460631; psb36-Na
22.73Single6GPXMK08126GPX-CCR2-MK0812
22.73Single6LPLZM2413856LPL-A2A-ZM241385-Na
22.73Single6S0QZM2413856S0Q-A2A-ZM241385
22.73Single6WQAZM2413856WQA-A2A-ZM241385-Na
22.73Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
22.73Single7C4SS1P7C4S-S1P3-S1P
22.73Single7CFNINT-7777CFN-GPBA-INT-777-Gs/&β;1/&γ;2
22.73Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
22.73Single7RM5ZM2413857RM5-A2A-ZM241385-Na
22.73Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
22.73Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
22.73Single8FYNZM2413858FYN-A2A-ZM241385-Na
22.73Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2
22.73Single8GDCPGE28GDC-EP3-PGE2-Gi1/&β;1/&γ;2
22.73Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
22.73Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
22.73Consensuscb2_onOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
22.73Consensusep3_onOrthosteric Ligand8GDC-EP3-PGE2-Gi1/&β;1/&γ;2
22.58Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
22.58Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
22.58Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
22.58Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
22.58Consensusgi_class-dOrthosteric Ligandgi_ste
22.58Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
22.22Single3UZAGTPL92363UZA-A2A-GTPL9236
22.22Single6ME5Agomelatine6ME5-MT1-Agomelatine
22.22Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
22.22Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
22.22Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
22.22Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
22.22Single8EITDoconexent8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
22.22Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
22.22Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
22.22Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
22.22Single8J6QBeta-hydroxybutyrate8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
22.22Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
21.88Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
21.88Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
21.88Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
21.88Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
21.88Single8IY6Endothelin-18IY6-ETB-Endothelin-1
21.88Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
21.74Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
21.74Single5XR8AM8415XR8-CB1-AM841
21.74Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
21.74Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
21.74Single7TUYGSK682753A7TUY-GPR183-GSK682753A
21.74Single7W41PD1762527W41-BB2-PD176252
21.74Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
21.74Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
21.74Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.74Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
21.74Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
21.74Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
21.74Consensusbombesin_offOrthosteric Ligandbb2_off
21.74Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
21.74Consensuscyslt1_off_ortoalloOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
21.74Consensusffa4_onOrthosteric Ligand8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
21.74Consensusgs_ffaOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2 8GDB-EP4-PGE2-Gs/&β;1/&γ;2
21.74Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
21.74Consensuslpa_onOrthosteric Ligandlpa1_on
21.43Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
21.43Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;2
21.21Consensusgs_crfOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
21.05Single6HLLCP999946HLL-NK1-CP99994
21.05Single6TP4ACT-4622066TP4-OX1-ACT-462206
21.05Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
21.05Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
21.05Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
21.05Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2
21.05Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2
21.05Single8IJANiacin8IJA-HCA2-Niacin-Gi1/&β;1/&γ;2
21.05Single8K5BNiacin8K5B-HCA2-Niacin
21.05Consensusgo_adhesionOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
21.05Consensusgo_class-b2Orthosteric Ligandgo_adhesion
21.05Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
20.83Single5X33BIIL2605X33-BLT1-BIIL260
20.83Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
20.83Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
20.83Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.83Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
20.83Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
20.83Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
20.83Single8GCPPGE28GCP-EP4-PGE2-Gi1/&β;1/&γ;2
20.83Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2
20.83Single8J6DEP1418J6D-C3aB-EP141-Go/&β;1/&γ;2
20.83Consensuscannabinoid_onOrthosteric Ligandcb1_on cb2_on
20.83Consensuscb1_onOrthosteric Ligand8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
20.83Consensusgi_cannabinoidOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
20.83Consensusgi_prostanoidOrthosteric Ligand8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GDC-EP3-PGE2-Gi1/&β;1/&γ;2 8GCM-EP4-L902688-Gi1/&β;1/&γ;2
20.83Consensusgs_trhOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
20.83Consensusprostanoid_onOrthosteric Ligandep_on fpa_on
20.83Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
20.69Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
20.69Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
20.69Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.69Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
20.69Consensusclass-d_onOrthosteric Ligandste2_on
20.69Consensusgi_class-dOrthosteric Ligandgi_ste
20.69Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
20.59Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
20.59Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
20.59Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
20.00Single3VG9ZM2413853VG9-A2A-ZM241385-Antibody
20.00Single3VGAZM2413853VGA-A2A-ZM241385-Antibody
20.00Single4S0VSuvorexant4S0V-OX2-Suvorexant
20.00Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
20.00Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
20.00Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/&β;1/&γ;2
20.00Single6K1QIRL25006K1Q-ETB-IRL2500
20.00Single6TPJSuvorexant6TPJ-OX2-Suvorexant
20.00Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
20.00Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
20.00Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
20.00Single7F8ULintitript7F8U-CCKA-Lintitript
20.00Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
20.00Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
20.00Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
20.00Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
20.00Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
20.00Single7XRRLemborexant7XRR-OX2-Lemborexant
20.00Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
20.00Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
20.00Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
20.00Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
20.00Single8GAGYVF8GAG-CB1-YVF-Gi1/&β;1/&γ;2
20.00Single8GNGIstradefylline8GNG-A2A-Istradefylline
20.00Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/&β;1/&γ;2
20.00Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
20.00Single8WRZ8D08WRZ-CB1-8D0-Arrestin1
20.00Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Consensusa2a_off_alloOrthosteric Ligand6ZDR-A2A-HMS1413f12-Na 6GT3-A2A-Imaradenant-Na 8CU7-A2A-LJ-4517-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PubChem 92460631; psb36-Na 5MZJ-A2A-Theophylline-Na 5OLO-A2A-Tozadenant-Na 5OLH-A2A-Vipadenant-Na 5NM4-A2A-ZM241385-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5MZP-A2A-Caffeine-Na 8CIC-A2A-Etrumadenant-Na
20.00Consensusadgrg2_onOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Consensusbombesin_onOrthosteric Ligandbb2_on bb1_on
20.00Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
20.00Consensusep4_onOrthosteric Ligand7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2
20.00Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Consensusffa3_on_alloOrthosteric Ligand8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
20.00Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
20.00Consensusgs_lipidOrthosteric Ligandgs_ffa gs_prostanoid
20.00Consensusgs_prostanoidOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.51Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
19.44Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
19.44Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
19.35Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
19.35Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/&β;1/&γ;2
19.35Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
19.35Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
19.23Single5EE7MK08935EE7-Glucagon-MK0893
19.23Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.23Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
19.23Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
19.23Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
19.23Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
19.23Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
19.23Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
19.23Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.23Single8XZFWN5618XZF-Apelin-WN561-Gi1/&β;1/&γ;2
19.23Consensusclass-d_offOrthosteric Ligandste2_off
19.23Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
19.23Consensusgs_adgrOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
19.23Consensusgs_class-b2Orthosteric Ligandgs_adgr
19.05Single3REYPubChem 56973REY-A2A-PubChem 5697
19.05Single5IU4ZM2413855IU4-A2A-ZM241385-Na
19.05Single5IU7Q274563465IU7-A2A-Q27456346-Na
19.05Single5IUBQ274563445IUB-A2A-Q27456344-Na
19.05Single5JTBZM2413855JTB-A2A-ZM241385
19.05Single5K2BZM2413855K2B-A2A-ZM241385-Na
19.05Single5K2CZM2413855K2C-A2A-ZM241385-Na
19.05Single5NM4ZM2413855NM4-A2A-ZM241385-Na
19.05Single6MH8ZM2413856MH8-A2A-ZM241385
19.05Single6TP3Nemorexant6TP3-OX1-Nemorexant
19.05Single6TPKRetosiban6TPK-OT-Retosiban
19.05Single6V9SGTPL114036V9S-OX1-GTPL11403
19.05Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
19.05Single6ZDVPubChem 9840736ZDV-A2A-PubChem 984073-Na
19.05Single7AROLUF58337ARO-A2A-LUF5833-Na
19.05Single7BB6Acyclovir triphosphate7BB6-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
19.05Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2
19.05Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.05Single8HQN9(S)-HODE8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
19.05Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
19.05Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
19.05Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
19.05Consensusffa2_onOrthosteric Ligand8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
19.05Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
19.05Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
19.05Consensusvasopressin-ot_offOrthosteric Ligandot_off
18.92Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
18.92Consensuspth_onOrthosteric Ligandpth1_on pth2_on
18.75Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
18.75Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
18.75Single8WCBCyclohexylammonium ion8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.75Single8WCCCyclohexylammonium ion8WCC-TA1-Cyclohexylammonium ion
18.75Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
18.75Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
18.52Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
18.52Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
18.52Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
18.52Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
18.52Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
18.52Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
18.18Single3EMLZM2413853EML-A2A-ZM241385
18.18Single4YAYZD-71554YAY-AT1-ZD-7155
18.18Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
18.18Single5K2AZM2413855K2A-A2A-ZM241385-Na
18.18Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
18.18Single5UENDU1725UEN-A1-DU172
18.18Single5VRAZM2413855VRA-A2A-ZM241385-Na
18.18Single6IIVDaltroban6IIV-TP-Daltroban
18.18Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2
18.18Single6LMLGlucagon6LML-Glucagon-Glucagon
18.18Single6LPJZM2413856LPJ-A2A-ZM241385-Na
18.18Single6LPKZM2413856LPK-A2A-ZM241385-Na
18.18Single6S0LZM2413856S0L-A2A-ZM241385
18.18Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
18.18Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
18.18Single7V3ZPubMed 1048957V3Z-CB1-PubMed 104895
18.18Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
18.18Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
18.18Single8EJKTAK-8758EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
18.18Single8FEGPRD_0025178FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
18.18Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
18.18Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-alpha-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
18.18Consensuscb1_on_alloOrthosteric Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
18.18Consensuscrf1_onOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
18.18Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
18.18Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
18.18Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
18.18Consensustp_offOrthosteric Ligand6IIV-TP-Daltroban 6IIU-TP-Ramatroban
17.86Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
17.86Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/&β;1/&γ;2
17.86Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
17.86Consensuscx3cr_onOrthosteric Ligandcx3cr1_on
17.86Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
17.65Consensusclass-c_onOther Ligandgabab_on mglu_on
17.39Single4NTJAZD12834NTJ-P2Y12-AZD1283
17.39Single5N2SPSB365N2S-A1-PSB36
17.39Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
17.39Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
17.39Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
17.39Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
17.39Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
17.39Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
17.39Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
17.39Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
17.39Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
17.39Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
17.39Single7YXAONO-54306087YXA-S1P5-ONO-5430608
17.39Single8GDAL9026888GDA-EP4-L902688-Gs/&β;1/&γ;2
17.39Single8GNEKW-63568GNE-A2A-KW-6356-Na
17.39Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
17.39Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
17.39Single8QOTNanobody E8QOT-μ-Nanobody E
17.39Consensusccr2_off_alloOther Ligand5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
17.39Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
17.39Consensusep_offOrthosteric Ligandep4_off
17.39Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
17.24Single3OE0CVX153OE0-CXCR4-CVX15
17.24Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1
17.24Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
17.24Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
17.24Consensuscx3cr1_onOrthosteric Ligand7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
17.24Consensusmc5_onOrthosteric Ligand8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
17.14Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
17.14Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
16.67Single5TZR-5TZR-FFA1 (GPR40)-MK8666
16.67Single5XRAAM115425XRA-CB1-AM11542
16.67Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
16.67Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
16.67Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
16.67Single6TQ9SB-4081246TQ9-OX1-SB-408124
16.67Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
16.67Single7FEEPubMed 1048957FEE-CB1-PubMed 104895-ZCZ011
16.67Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
16.67Single7WV9PubMed 1048957WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
16.67Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
16.67Single8GDBPGE28GDB-EP4-PGE2-Gs/&β;1/&γ;2
16.67Single8GUSHU-3088GUS-CB2-HU-308-Gi1/&β;1/&γ;2
16.67Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
16.67Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
16.67Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
16.67Single8X79MRE-2698X79-I2-MRE-269-Gs/&β;1/&γ;2
16.67Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
16.67Consensuscck_onOrthosteric Ligandccka_on cckb_on
16.67Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
16.67Consensuschemerin_onOrthosteric Ligandcml1_on
16.67Consensuscml1_onOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
16.67Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
16.67Consensusgi_ffaOrthosteric Ligand8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
16.67Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
16.67Consensusgs_compl-peptideOrthosteric Ligand8I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Consensusnpy_offOrthosteric Ligandnpy2_off npy1_off
16.67Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
16.67Consensusrelaxin_onOrthosteric Ligandrxfp4_on
16.22Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
16.22Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
16.22Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
16.22Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
16.22Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
16.13Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.13Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
16.13Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
16.13Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
16.13Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
16.13Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
16.13Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
16.13Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
16.00Single6IIURamatroban6IIU-TP-Ramatroban
16.00Single6KQIPubMed 1048956KQI-CB1-PubMed 104895-ORG27569
16.00Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
16.00Single7Y24Octreotide7Y24-SST2-Octreotide-Go/&β;1/&γ;2
16.00Single7Y66BM2137Y66-C5a1-BM213-Gi1/&β;1/&γ;2
16.00Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2
16.00Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2
16.00Consensuscb1_off_alloOrthosteric Ligand6KQI-CB1-PubMed 104895-ORG27569
16.00Consensusep_onOrthosteric Ligandep4_on ep2_on ep3_on
16.00Consensustsh_on_alloOther Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
15.79Single3OE6IT1t3OE6-CXCR4-IT1t
15.79Single3OE8IT1t3OE8-CXCR4-IT1t
15.79Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
15.79Single6ME9Ramelteon6ME9-MT2-Ramelteon
15.79Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2
15.79Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
15.79Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
15.62Single4XT3Fractalkine4XT3-US28-Fractalkine
15.62Single6FJ3PTH6FJ3-PTH1-PTH
15.62Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
15.62Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
15.62Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
15.62Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.62Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
15.62Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
15.62Consensusgi_neuromedinOrthosteric Ligand7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
15.62Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
15.38Single7CX2PGE27CX2-EP2-PGE2-Gs/&β;1/&γ;2
15.38Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2
15.38Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
15.38Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
15.38Consensusc5a1_off_ortoalloOrthosteric Ligand6C1Q-C5a1-PMX53-NDT9513727 6C1R-C5a1-PMX53-Avacopan; Na
15.38Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.15Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
15.15Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
15.15Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
15.15Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
15.15Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
15.15Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
15.00Single3OE9IT1t3OE9-CXCR4-IT1t
15.00Single5L7IVismodegib5L7I-SMO-Vismodegib
15.00Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
15.00Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
15.00Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
15.00Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/&β;1/&γ;2
15.00Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
14.81Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
14.81Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
14.81Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
14.81Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
14.81Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
14.81Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
14.71Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
14.71Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
14.71Single7VGXNeuropeptide Y7VGX-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
14.71Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
14.71Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
14.71Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
14.71Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
14.29Single3ODUIT1t3ODU-CXCR4-IT1t
14.29Single3PWHZM2413853PWH-A2A-ZM241385
14.29Single4XT1Fractalkine4XT1-US28-Fractalkine
14.29Single5K2DZM2413855K2D-A2A-ZM241385
14.29Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
14.29Single5ZKQABT-4915ZKQ-PAF-ABT-491
14.29Single6JZHZM2413856JZH-A2A-ZM241385-Na
14.29Single6PS7ZM2413856PS7-A2A-ZM241385-Na
14.29Single7BR3Elagolix7BR3-GnRH1-Elagolix
14.29Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
14.29Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
14.29Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
14.29Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
14.29Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
14.29Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
14.29Single8HMPPubChem 699214798HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
14.29Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
14.29Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.29Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
14.29Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
14.29Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
14.29Consensusnmur1_onOrthosteric Ligand7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Consensussmo_on_alloOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
14.29Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
13.95Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
13.89Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
13.79Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
13.79Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
13.79Single7SK5CXCL127SK5-ACKR3-CXCL12
13.79Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.79Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
13.79Consensussst_offOrthosteric Ligandsst2_off
13.64Single5NLXZM2413855NLX-A2A-ZM241385-Na
13.64Single5UVIZM2413855UVI-A2A-ZM241385
13.64Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
13.64Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
13.64Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
13.64Single7XOVSR1461317XOV-CCKA-SR146131-Gs/&β;1/&γ;2
13.64Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.64Single8GCML9026888GCM-EP4-L902688-Gi1/&β;1/&γ;2
13.64Single8K2WAMG4878K2W-CXCR3-AMG487
13.64Single8K4NVF08K4N-GPR34-VF0-Gi1/&β;1/&γ;2
13.64Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
13.64Consensusgnrh_offOrthosteric Ligandgnrh1_off
13.64Consensusm1_off_alloOther Ligand6WJC-M1-Atropine-Muscarinic toxin 7
13.51Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
13.33Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
13.33Single6W25SHU91196W25-MC4-SHU9119-Ca
13.33Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
13.33Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
13.33Single7XNACYN1548067XNA-SST2-CYN154806
13.33Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
13.33Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
13.33Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
13.33Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
13.16Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
13.16Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
13.04Single4QIMPubChem 249053754QIM-SMO-PubChem 24905375
13.04Single7F83PF-051904577F83-Ghrelin-PF-05190457
13.04Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
13.04Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
13.04Single8EJCTAK-8758EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
13.04Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
13.04Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/&β;1/&γ;2
13.04Consensuscck_offOrthosteric Ligandccka_off
13.04Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
13.04Consensusffa1_onOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.04Consensusffa_onOrthosteric Ligandffa4_on ffa1_on ffa2_on ffa3_on
13.04Consensusfsh_on_alloOther Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
13.04Consensushcar_offOrthosteric Ligandsuccinate_off
13.04Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
13.04Consensusp2y12_offOrthosteric Ligand4NTJ-P2Y12-AZD1283 7PP1-P2Y12-Selatogrel
13.04Consensussmo_offOrthosteric Ligand5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
13.04Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
12.90Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
12.90Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
12.90Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
12.90Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
12.90Consensusnmur2_onOrthosteric Ligand7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.90Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
12.50Single4JKVTaladegib (LY2940680)4JKV-SMO-Taladegib (LY2940680)
12.50Single4PHUFasiglifam4PHU-FFA1 (GPR40)-Fasiglifam
12.50Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
12.50Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
12.50Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
12.50Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
12.50Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
12.50Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
12.50Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
12.50Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
12.50Single8ID9Eicosapentaenoic acid8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
12.50Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
12.50Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
12.50Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
12.50Consensusgs_melanocortinOrthosteric Ligand7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2
12.12Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
12.12Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
12.12Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
12.12Single7D3SSecretin7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
12.12Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
12.12Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
12.12Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
12.12Single7SK3CXCL127SK3-ACKR3-CXCL12
12.12Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
12.12Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
12.12Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
12.12Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
12.12Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
12.12Consensusghrh_onOrthosteric Ligand7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
12.12Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
12.00Single5V56TC1145V56-SMO-TC114
12.00Single5V57TC1145V57-SMO-TC114
12.00Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
12.00Single6OS1TRV0266OS1-AT1-TRV026
12.00Single7F1TMIP-1a7F1T-CCR5-MIP-1a
12.00Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2
12.00Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
11.90Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
11.90Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
11.76Single5MZPCaffeine5MZP-A2A-Caffeine-Na
11.76Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
11.76Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
11.76Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
11.76Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
11.63Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
11.54Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
11.54Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
11.54Single6OS2TRV0266OS2-AT1-TRV026
11.54Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
11.54Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1
11.54Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2
11.54Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
11.54Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
11.54Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
11.54Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
11.54Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
11.43Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
11.43Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
11.43Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
11.43Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
11.11Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
11.11Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
11.11Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
11.11Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2
11.11Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
11.11Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.11Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
11.11Single7XKEBetahydroxyandrosterone7XKE-ADGRG2-Betahydroxyandrosterone-chim(NtGi1-Gs)/&β;1/&γ;2
11.11Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
11.11Single8PWNTheophylline8PWN-A2A-Theophylline
11.11Consensuscckb_onOrthosteric Ligand7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
11.11Consensuscyslt2_offOrthosteric Ligand6RZ6-CysLT2-ONO-2570366 6RZ9-CysLT2-ONO-2770372 6RZ8-CysLT2-ONO-2080365
11.11Consensuscyslt_offOrthosteric Ligandcyslt2_off
11.11Consensusep2_onOrthosteric Ligand7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
11.11Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
10.81Consensusglp_onOrthosteric Ligandglp1_on glp2_on
10.71Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
10.71Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
10.71Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.71Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
10.71Single8INRAlpha-MSH8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
10.71Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.71Consensusgs_bombesinOrthosteric Ligand8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.71Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.71Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
10.53Single3RFMCaffeine3RFM-A2A-Caffeine
10.53Single8A2OTheophylline8A2O-A2A-Theophylline-Na
10.53Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
10.34Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
10.34Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
10.34Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
10.34Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
10.34Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
10.34Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
10.00Single6LI0GTPL98046LI0-GPR52-GTPL9804
10.00Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
10.00Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
10.00Single7SHEPI; PE7SHE-GPR158-PI; PE
10.00Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
10.00Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
10.00Single8F76-8F76-OR51E2-Gs/&β;1/&γ;2
10.00Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.00Consensussmo_off_alloOrthosteric Ligand6D32-SMO-Cyclopamine-Cyclopamine
9.76Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
9.68Single7F4DAlpha-MSH7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
9.68Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
9.68Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.68Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.68Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
9.68Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
9.52Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
9.52Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
9.52Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
9.52Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
9.52Consensusclass-t_onOrthosteric Ligandtaste2_on
9.52Consensusgs_class-tOrthosteric Ligandgs_taste
9.52Consensusgs_tasteOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
9.52Consensusm4_on_alloOther Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
9.52Consensustaste2_onOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
9.38Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
9.38Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
9.38Consensusnmur_onOrthosteric Ligandnmur1_on nmur2_on
9.38Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
9.09Single4K5YCP-3763954K5Y-CRF1-CP-376395
9.09Single5U09Taranabant5U09-CB1-Taranabant
9.09Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
9.09Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
9.09Single7W0OElabela7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
9.09Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
9.09Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.09Consensusgs_neuromedinOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.09Consensusm2_on_alloOther Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
8.82Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
8.82Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
8.70Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
8.70Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
8.70Single8IYXYL-3658IYX-GPR34-YL-365
8.70Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/&β;1/&γ;2
8.70Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
8.70Consensuscxcr_onOrthosteric Ligandcxcr1_on cxcr2_on
8.57Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
8.57Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
8.57Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
8.57Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
8.33Single4Z9GCP-3763954Z9G-CRF1-CP-376395
8.33Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
8.33Single8GTIBMK-C2058GTI-CRF1-BMK-C205
8.11Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
8.11Single7TYIAmylin7TYI-CT-Amylin-Gs/&β;1/&γ;2
8.11Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
8.00Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.00Single7Y27Somatostatin-147Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.00Single8GTGBMK-I1528GTG-CRF1-BMK-I152
8.00Consensusgs_sstOrthosteric Ligand7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.69Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2
7.69Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
7.69Single7XOWGastrin7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
7.69Single7XOXCholecystokinin-87XOX-CCKB-Cholecystokinin-8-Gq/&β;1/&γ;2
7.69Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.69Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
7.69Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
7.69Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
7.50Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
7.50Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
7.41Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
7.41Single4PY02MeSATP4PY0-P2Y12-2MeSATP
7.41Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/&β;1/&γ;2
7.41Single8GTMBMK-C2038GTM-CRF1-BMK-C203
7.41Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.41Single8IBUErythromycin A8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.41Consensuschemokine_offOrthosteric Ligandcxcr_off
7.41Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II
7.41Consensuscxcr_offOrthosteric Ligandcxcr4_off
7.32Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
7.14Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
7.14Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/&β;1/&γ;2
7.14Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
7.14Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
6.98Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
6.90Single6KNMJN241-96KNM-Apelin-JN241-9
6.90Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
6.90Single8SAI1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
6.90Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
6.90Consensusmotilin_onOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.67Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
6.67Consensusclass-c_offOther Ligandgabab_off mglu_off
6.67Consensusgs_ctOrthosteric Ligand7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
6.45Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
6.45Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
6.25Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.06Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
6.06Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
6.06Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
5.41Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
5.41Consensuscalcitonin_onOrthosteric Ligandct_on ctlike_on
5.26Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
5.13Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
5.00Single7XKDBetahydroxyandrosterone7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
5.00Single8F0KPramlintide analogue san3858F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
5.00Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/&β;1/&γ;2
4.88Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
4.88Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
4.76Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
4.76Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
4.76Single7F61Cholesterol7F61-H3-PF-03654746-Cholesterol
4.76Consensusadgrg3_onOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
4.76Consensusgip_on_alloOther Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
4.76Consensush3_on_alloOther Ligand7F61-H3-PF-03654746-Cholesterol
4.65Single8F2APramlintide analogue san3858F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
4.55Single4O9RCyclopamine4O9R-SMO-Cyclopamine
4.55Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
4.55Consensussmo_on_alloOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
4.44Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
4.35Single4QINSAG1.54QIN-SMO-SAG1.5
4.35Single6C1QNDT95137276C1Q-C5a1-PMX53-NDT9513727
4.35Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
4.35Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
4.35Single7F8YDevazepide7F8Y-CCKA-Devazepide
4.35Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
4.35Single8HNNSCH5467388HNN-CXCR3-SCH546738
4.35Consensusclass-f_offOrthosteric Ligandsmo_off
4.35Consensusp2y_offOrthosteric Ligandp2y1_off p2y12_off
4.17Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
4.17Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
4.17Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
4.17Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.17Single7XJJGalanin7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
4.17Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
4.17Single8JD6N-(3-chlorophenyl)pyridine-2-carboxamide8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
4.17Single8T3VDHA8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.17Consensusgi_class-fOrthosteric Ligandgi_frizzled
4.17Consensusgi_frizzledOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
4.17Consensusgo_galaninOrthosteric Ligand7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
4.17Consensuslh_on_alloOther Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
4.00Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/&β;1/&γ;2
4.00Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
4.00Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
4.00Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
4.00Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
4.00Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
4.00Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
4.00Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
4.00Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
3.85Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
3.85Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
3.85Single8FN1Neurotensin/neuromedin N8FN1-NTS1-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
3.85Single8JPCNeurotensin 8-138JPC-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
3.85Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
3.70Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
3.70Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
3.70Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
3.70Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.70Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
3.57Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/&β;1/&γ;2
3.57Single7SHEPI; PE7SHE-GPR158-PI; PE
3.57Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.57Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.57Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
3.45Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.45Consensusgs_galaninOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.33Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.33Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
3.23Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
3.23Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/&β;1/&γ;1
3.12Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
2.94Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
2.56Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
2.56Single7TYLAmylin7TYL-CT-Amylin-Gs/&β;1/&γ;2
2.56Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/&β;1/&γ;2; RAMP2
2.50Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
2.44Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
2.13Single8F2BPramlintide analogue san458F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
2.04Single8F0JPramlintide analogue san458F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2

Consensus Members
Id Members
6BQH 6BQH-5-HT2C-Ritanserin
Net Summary
Imin 3.23
Number of Linked Nodes 275
Number of Links 306
Number of Hubs 39
Number of Links mediated by Hubs 157
Number of Communities 5
Number of Nodes involved in Communities 33
Number of Links involved in Communities 49
Path Summary
Number Of Nodes in MetaPath 66
Number Of Links MetaPath 65
Number of Shortest Paths 73126
Length Of Smallest Path 3
Average Path Length 14.153
Length of Longest Path 32
Minimum Path Strength 1.38
Average Path Strength 6.26086
Maximum Path Strength 21.43
Minimum Path Correlation 0.7
Average Path Correlation 0.922597
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 3.7037
Average % Of Corr. Nodes 47.8765
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 42.6965
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following differences:
Id1st Network2nd Network
5ht2c_off_on5ht2c_off5ht2c_on
This network is also present in following consensuses:
IdComponents
5ht2_off5ht2a_off
5ht2b_off
5ht2c_off



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