Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
1G.HN.52 0.720616403
2G.S1.06 4.759764178
3G.H1.01 4.234294179
4G.H1.03 1.12072409
5G.S2.02 1.41417405
6G.S2.03 4.101855139
7G.S2.06 3.57468509
8G.S3.03 5.57095688
9G.S3.04 8.849334137
10G.S3.06 9.352914137
11G.s3h2.03 4.68763419
12G.H2.01 4.38535419
13G.H2.06 5.42663519
14G.H2.07 5.12389619
15G.h2s4.01 8.9807409
16G.S4.07 5.10517408
17G.s4h3.04 6.171834188
18G.H3.01 2.31764909
19G.H3.08 3.94924408
20G.H3.09 4.91467569
21G.H3.13 7.86907666
22G.H3.17 8.81308515
23G.S5.05 4.349025119
24G.S5.07 3.47204509
25G.hgh4.01 4.44431506
26G.hgh4.02 4.21809408
27G.hgh4.04 2.27075406
28G.hgh4.05 10.86406
29G.hgh4.08 6.93491406
30G.hgh4.11 3.37167405
31G.hgh4.20 3.29173503
32G.hgh4.21 5.43076404
33G.H4.03 2.74355404
34G.H4.05 5.25548405
35G.H4.07 6.7231495
36G.H4.08 4.4994593
37G.H4.10 7.85489507
38G.H4.12 6.36813494
39G.H4.15 7.10925408
40G.h4s6.12 4.16188402
41G.h4s6.20 4.47022464
42G.S6.02 6.44099668
43G.S6.05 6.83703595
44G.s6h5.01 5.401894119
45G.s6h5.05 4.182785119
46G.H5.03 4.489675119
47G.H5.05 4.16529485
48G.H5.06 5.233764114
49G.H5.08 4.30246888
50G.H5.17 4.18603665
51G.H5.20 3.08605408
52G.H5.23 5.554875194
53b.1x4 1.7821408
54b.1x9 2.13238404
55b.lh12x2 3.92619408
56b.b1x3 4.02654407
57b.l1x3 9.12292539
58b.l1x6 8.28725519
59b.b2x1 6.24793518
60b.b2x5 5.99981637
61b.b3x3 3.58535408
62b.l3x1 7.77698419
63b.l3x2 5.755535169
64b.b4x3 4.039694147
65b.b4x6 9.50359639
66b.l4x2 8.45508534
67b.b5x2 6.488407
68b.b5x3 5.26982639
69b.b5x5 4.44801405
70b.b5x7 5.58086407
71b.l5x1 4.312915148
72b.l5x5 7.77043609
73b.b6x1 4.35374419
74b.b6x5 4.02057606
75b.l6x5 5.609474154
76b.b7x1 5.867234154
77b.b7x4 3.729044148
78b.b8x3 3.31109406
79b.b8x4 5.499685146
80b.l8x5 2.21851403
81b.b9x3 3.1567406
82b.l9x3 6.65356619
83b.l9x6 5.05269818
84b.b10x5 4.16876609
85b.b11x4 5.2588419
86b.l11x2 8.21386419
87b.b12x6 7.35897718
88b.b12x7 5.40834219
89b.b13x7 7.57051557
90b.l13x3 7.39621659
91b.l13x6 5.20645519
92b.l13x7 4.46488459
93b.b14x3 3.91428455
94b.b15x1 6.03365559
95b.l15x1 4.97693517
96b.l15x2 6.08523459
97b.b16x4 9.88705456
98b.b16x5 4.65914405
99b.b16x6 7.5624758
100b.b17x5 6.75648447
101b.b17x7 7.91771448
102b.l17x3 7.76268749
103b.l17x6 7.60131419
104b.b18x3 4.73613448
105b.b18x5 5.02464405
106b.l18x1 6.107547126
107b.l18x2 5.35654127
108b.b19x2 6.42683646
109b.b19x4 5.77923448
110b.l19x2 6.33644549
111b.b20x4 8.55758648
112b.b20x6 6.42465646
113b.b20x7 4.45599409
114b.l20x2 5.68897509
115b.b21x1 8.57909447
116b.b21x2 2.58588406
117b.b21x5 5.16994404
118b.b21x7 5.8725605
119b.l21x2 4.72372404
120b.l21x7 3.54987415
121b.b22x5 5.594415127
122b.l22x5 6.508645209
123b.b23x6 6.13601817
124b.l23x1 5.83132516
125b.b24x4 6.95705416
126b.b24x6 6.26389418
127b.l24x3 3.82267505
128b.l25x3 7.78246579
129b.l25x4 2.91215475
130b.l25x6 11.3469518
131b.b26x3 3.59373406
132b.l28x1 9.19901719
133b.l28x2 7.33029479
134b.b28x2 4.93922404
135b.b28x4 6.97993476
136b.b28x6 8.01923579
137g.l1x4 4.19508
138g.h2x11 8.827544126
139g.ctx3 5.2942609
140g.ctx6 3.18272406
141g.ctx14 5.07471439
142g.ctx15 5.51146439
143g.ctx16 4.2507738
1441x39 3.58247406
1451x50 4.51433509
1462x40 1.79881409
1472x41 1.45418404
1482x42 3.91823608
1492x46 4.151144109
1502x50 5.157325109
1512x51 2.57061407
1522x57 3.52206407
153E1x52 1.52946406
1543x49 4.495594198
1553x51 6.20204408
1563x56 3.3018407
1574x50 4.547694109
158E2 6.33112623
1595x39 4.66283527
1605x58 4.02523609
1616x48 4.79378508
1626x59 1.85017404
163E3 2.839211223
1647x32 0.966832421
1657x49 5.099924109
1667x53 3.62434609
1678x50 2.86437608
168Lig 37.53292120
169E1 5.91723920
1706x29 1.37497406
171H.HA.12 0.046513400
172H.HB.02 0.0154513700
173H.HB.05 0.0252069400
174H.hbhc.14 0.0493687400
175H.HC.03 0.0293659400
176H.HC.04 0.0364343500
177H.HC.11 0.0435442600
178H.hchd.01 0.0195264500
179H.HD.07 0.0205202500
180H.hdhe.01 0.0129293400
181H.HE.04 0.0453171400
182H.HE.05 0.0356264400
183H.hehf.04 0.0256745500
184NT 99.6069920
185I1 3.18975570
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1G.S1.03 G.hns1.01 11.073614.7124NoNo094
2G.S1.03 G.S3.06 11.21793.97574NoYes097
3G.S3.04 G.S3.06 13.95129.18339YesYes1377
4G.S1.01 G.S3.04 13.56825.40115NoYes077
5G.S1.01 G.S3.02 13.37313.86287NoNo074
6G.S3.06 b.l5x5 22.630716.3301YesYes079
7G.h2s4.01 b.l5x5 20.088312.4741YesYes099
8G.H2.07 G.h2s4.01 20.59293.50618YesYes099
9G.H2.04 G.H2.07 99.86436.25373NoYes099
10G.H2.04 G.H3.08 99.87416.97548NoYes098
11G.H3.08 G.S4.04 1005.33913YesNo089
12G.H3.09 G.S4.04 94.58685.01404YesNo099
13G.H3.09 G.H3.13 96.59124.23457YesYes696
14G.H3.13 G.S6.01 96.31543.05839YesNo665
15G.S6.01 G.S6.02 96.96013.36417NoYes658
16G.H5.10 G.S6.02 97.113110.8308NoYes078
17G.H5.10 G.S5.03 48.18858.69905NoNo079
18G.S5.03 G.S5.05 48.12813.20357NoYes099
19G.H5.07 G.S5.05 91.93293.24967NoYes099
20G.H5.07 G.S4.03 91.81693.3302NoNo097
21G.S1.04 G.S4.03 87.39543.51973NoNo077
22G.S1.04 G.S3.03 87.27363.51513NoYes078
23b.b26x2 b.b2x3 24.56315.13345NoNo076
24b.b26x1 b.b26x2 24.84533.11072NoNo097
25b.b26x1 b.l28x1 24.98845.11452NoYes099
26b.b2x1 b.l28x1 44.71876.22012YesYes189
27b.b2x1 b.b6x1 43.22265.17528YesYes189
28b.b6x1 b.l9x6 43.60585.61588YesYes198
29G.H2.07 b.l9x6 85.90313.74033YesYes198
30G.H5.10 G.S6.04 48.940710.7326NoNo079
31G.S5.05 G.S6.04 48.20734.05655YesNo099
32G.S2.07 G.S3.02 13.17799.37894NoNo034
33G.H5.08 G.S3.03 85.84883.28889YesYes888
34G.H2.06 b.l9x6 36.83363.29156YesYes198
35G.H2.06 b.l17x6 18.30277.08135YesYes199
36G.H2.06 b.b18x1 18.15523.98728YesNo099
37G.H3.17 b.l28x1 13.1593.73596YesYes159
38b.l25x6 b.l28x1 13.175319.5548YesYes189
39G.H3.09 G.H4.15 13.11846.45727YesYes098
40G.H3.06 G.H4.15 10.71998.91945NoYes068
41G.H3.17 b.l23x1 12.67316.43975YesYes156
42b.l23x1 b.l25x6 12.66811.8189YesYes168
43G.H5.08 G.H5.12 85.17643.15591YesNo087
44G.H5.12 I2x50 85.0522.48822NoNo078
45G.H5.15 I2x50 84.92742.10655NoNo088
46G.H5.15 G.H5.19 84.80273.35232NoNo088
473x53 G.H5.19 84.55292.777NoNo088
483x53 G.H5.23 80.4733.59744NoYes084
493x50 G.H5.23 76.52410.9042NoYes094
503x50 5x58 35.65934.10539NoYes099
513x50 7x53 41.6363.65994NoYes099
52b.l17x6 b.l19x1 18.66264.66271YesNo099
53b.l17x5 b.l19x1 36.41143.91433NoNo069
54b.l17x5 b.l19x2 36.10882.92197NoYes069
55b.l17x3 b.l19x2 33.32785.16001YesYes499
56b.b20x6 b.l17x3 27.13813.1167YesYes469
57b.b17x7 b.b20x6 20.34319.12256YesYes486
58b.b17x7 b.b21x1 16.97024.39274YesYes487
59b.1x19 b.b21x1 15.46639.81766NoYes067
60b.1x15 b.1x19 12.52144.44627NoNo076
61b.1x12 b.1x15 11.5851.48231NoNo067
62b.b18x1 b.l19x1 18.05169.7915NoNo099
63b.l21x7 b.l23x1 24.66543.97935YesYes156
64b.b23x6 b.l21x7 22.60213.59151YesYes175
65b.b23x6 b.b24x6 17.79326.57811YesYes178
66b.b21x7 b.b24x6 17.13228.70081YesYes058
67b.l27x5 g.ctx4 18.13434.71642NoNo057
68g.ctx3 g.ctx4 17.77964.08547YesNo097
69g.ctx3 g.ctx5 12.2133.18847YesNo099
70b.lhb1x11 g.ctx5 12.03123.85997NoNo049
71b.b25x7 b.lhb1x11 11.48524.99633NoNo074
72b.b2x4 b.b6x5 10.61873.02316NoYes066
73b.b10x4 b.b2x4 10.71039.75667NoNo066
74b.b2x5 b.l27x1 16.396910.7596YesNo378
75b.l27x3 b.l27x5 15.91926.04694NoNo075
76b.b10x2 b.b10x4 11.31264.72284NoNo066
77b.b10x1 b.l9x6 19.23973.1508NoYes098
78b.b10x2 b.b14x3 10.84814.93374NoYes065
79b.b11x5 b.b14x3 13.61134.45905NoYes065
80b.b10x1 b.b11x5 19.08973.5183NoNo096
816x51 Lig 46.94494.8686NoYes260
826x51 7x41 47.61532.89561NoNo067
836x48 7x41 47.94323.60799YesNo087
846x44 6x48 25.98015.67524NoYes098
855x54 6x44 27.39763.12451NoNo089
863x47 5x54 27.55864.13574NoNo098
873x47 5x58 27.72835.98961NoYes099
886x48 7x45 26.35995.48249YesNo089
897x45 7x49 26.81296.1457NoYes099
903x43 7x49 31.08844.00104NoYes1089
913x43 7x53 36.17774.63969NoYes089
92E2 Lig 25.01636.35376YesYes230
93G.S2.07 G.s2s3.02 12.98252.07852NoNo034
94G.s2s3.02 H.HA.09 12.00210.0239646NoNo040
95H.HA.09 H.HA.12 11.69040.0228395NoYes000
96H.HA.12 H.hbhc.14 11.22280.107565YesYes000
97b.l27x1 b.l27x3 16.04855.40854NoNo387
98b.b2x3 b.b2x5 20.32553.95387NoYes367
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
2x563x325.029630NoNo7721
2x577x424.13320YesNo7721
3x22E210.06052NoYes3321
3x32Lig4.315662NoYes7010
3x334x573.033492NoNo5712
3x33Lig4.782242NoYes5010
3x36Lig6.220890NoYes7010
4x60E25.086262NoYes5321
4x605x398.477882NoYes5722
E2E240.34092YesYes3311
E2E2x527.187542YesNo3411
5x39E25.187522YesYes7321
5x36E27.524432NoYes4321
E2E2x519.445862YesNo3312
E2x52Lig8.364692NoYes4010
E2Lig6.353762YesYes3010
5x395x434.065222YesNo7521
5x43Lig3.43462NoYes5010
6x51Lig4.86862NoYes6010
6x55Lig3.812672NoYes5010
7x38Lig5.180070NoYes5010
7x42Lig3.809552NoYes7010
5x40Lig3.560632NoYes5010
E3E37.669212YesYes3322
3x26E24.482832NoYes6321
6x516x553.413872NoNo6511
3x29E25.650752NoYes4321
E2E2x503.411512YesNo3912
E1E23.832422YesYes0321
7x34Lig3.217870NoYes4010
6x58Lig3.158980NoYes3010
NTNT412.5882YesYes0011
E2NT3.587222YesYes3011
LigNT49.21522YesYes0001
2x64NT3.785292NoYes4021
E1NT8.692992YesYes0021
E1E116.33852YesYes0022
1x32NT2.968742NoYes3021
2x60Lig2.921642NoYes6010
6x517x412.895612NoNo6712
4x64E22.83250NoYes7321
E2E32.789422YesYes3312
7x31NT2.698630NoYes2021
3x375x432.510820NoNo6521
2x603x282.007722NoNo6512
5x406x591.966342NoYes5412
5x35E21.836362NoYes0321
1x427x421.723170NoNo7721
E1x49E21.519072NoYes5321
5x406x621.375062NoNo5012
5x34E21.209460NoYes0321
4x63E21.203272NoYes5321
7x27Lig0.4937960NoYes0010
1x27NT0.3385190NoYes0021
4x68E20.1834722NoYes0321
1x23E20.1781110NoYes0321
5x29E20.1460NoYes0321
1x21E20.1043330NoYes0321
7x24Lig0.1029070NoYes0010
1x24Lig0.1008892NoYes0010
2x68Lig0.09844440NoYes0010
6x64E20.07111110NoYes0321
1x241x250.05661112NoNo0012
5x28E20.04305560NoYes0321

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
78.95Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
70.00Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
59.26Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
59.26Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
56.52Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
56.52Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
56.52Consensusmop_offOrthosteric Ligand7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
55.00Single5C1MBU725C1M-μ-BU72
55.00Single7CFNINT-7777CFN-GPBA-INT-777-Gs/&β;1/&γ;2
55.00Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
55.00Consensusa1_on_alloOrthosteric Ligand7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
53.85Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
53.57Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
53.57Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
52.63Single8UO2Epinephrine8UO2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
52.38Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
52.38Single8E0GBU728E0G-μ-BU72
52.38Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
52.38Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
52.38Consensusa2_onOrthosteric Liganda2a_on a2b_on
52.17Single3NY9PubChem 9131033NY9-β2-PubChem 913103
52.17Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
52.17Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
52.00Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
51.72Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
50.00Single4EJ4Naltrindole4EJ4-δ-Naltrindole
50.00Single7CRHSKF839597CRH-D1-SKF83959-Gs/&β;1/&γ;2
50.00Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
50.00Single7YITNalfurafine7YIT-κ-Nalfurafine
50.00Single8GEHEpinephrine8GEH-β2-Epinephrine-Gs/&β;1/&γ;2
50.00Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
50.00Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
50.00Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
50.00Consensusadenosine_onOrthosteric Liganda1_on a2_on
50.00Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
50.00Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
50.00Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
50.00Consensusgo_5htOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
50.00Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
50.00Consensusgs_bileacidOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
50.00Consensusgs_steroidOrthosteric Ligandgs_bileacid
50.00Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
50.00Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
50.00Consensusnucleotide_onOrthosteric Ligandadenosine_on
50.00Consensusopioid_offOrthosteric Ligandkop_off mop_off nop_off dop_off
48.15Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
48.15Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
48.00Single3QAKUK-4320973QAK-A2A-UK-432097
48.00Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
47.83Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
47.83Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
47.83Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
47.83Consensusbileacid_onOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
47.83Consensussteroid_onOrthosteric Ligandbileacid_on
47.62Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
47.62Single5X7D(S)-Carazolol5X7D-β2-(S)-Carazolol-PubChem 129318963
47.62Single7XKAEpinephrine7XKA-β2-Epinephrine
47.62Single8DZQmomSalB8DZQ-κ-momSalB-Go/&β;1/&γ;2
47.62Single8UNYEpinephrine8UNY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
47.62Consensusadrenergic_offOrthosteric Ligandbeta_off alpha_off
47.62Consensusgo_opioidOrthosteric Ligand8DZQ-κ-momSalB-Go/&β;1/&γ;2
47.37Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
47.37Single8UO0Epinephrine8UO0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
47.37Single8UO3Epinephrine8UO3-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
47.37Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
47.37Consensusgi_nucleotideOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
46.43Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
46.43Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
46.15Single6PT2KGCHM076PT2-δ-KGCHM07
46.15Consensusangiotensin_onOrthosteric Ligandat1_on
46.15Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
45.83Single4UG2CGS216804UG2-A2A-CGS21680
45.83Single6PT3DPI-2876PT3-δ-DPI-287
45.83Single7XY6PubChem 117178317XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
45.83Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
45.83Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
45.45Single2YDVNECA2YDV-A2A-NECA
45.45Single4RWADIPP-NH24RWA-δ-DIPP-NH2
45.45Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
45.45Single4UHRCGS216804UHR-A2A-CGS21680
45.45Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
45.45Single5G53NECA5G53-A2A-NECA-Gs
45.45Single6J21Aprepitant6J21-NK1-Aprepitant
45.45Single7JVPSKF839597JVP-D1-SKF83959-Gs/&β;1/&γ;2
45.45Single7XTQR3997XTQ-GPBA-R399-Gs/&β;1/&γ;2
45.45Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/&β;1/&γ;2
45.45Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
45.45Consensus5ht1b_onOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
45.45Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
45.45Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
45.45Consensusdopamine_offOrthosteric Ligandd3_off d2_off d4_off
45.45Consensusffa4_onOrthosteric Ligand8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
45.45Consensusgi_dopamineOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
45.45Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A2A-NECA-Gs/&β;1/&γ;1 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
45.45Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2
45.45Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
45.00Single4DKLBeta-funaltrexamine4DKL-μ-Beta-funaltrexamine
45.00Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
45.00Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
45.00Single6PS4ICI 118-5516PS4-β2-ICI 118-551
45.00Single8GEGEpinephrine8GEG-β2-Epinephrine-Gs/&β;1/&γ;2
45.00Single8GGQEpinephrine8GGQ-β2-Epinephrine
45.00Single8GGTEpinephrine8GGT-β2-Epinephrine
45.00Single8UNZEpinephrine8UNZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
45.00Consensusdop_off_alloOrthosteric Ligand4N6H-δ-Naltrindole-Na
44.44Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
44.44Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
44.44Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
44.44Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
44.00Single4IARErgotamine4IAR-5-HT1B-Ergotamine
43.75Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
43.48Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
43.48Single6MXTSalmeterol6MXT-β2-Salmeterol
43.48Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
43.48Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
43.48Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
43.48Single7Y24Octreotide7Y24-SST2-Octreotide-Go/&β;1/&γ;2
43.48Single8JJ8Formoterol8JJ8-β2-Formoterol
43.48Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/&β;1/&γ;2
43.48Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
43.48Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
43.48Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
43.48Consensuspeptide_offOrthosteric Ligandopioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
43.33Single6IGLIRL16206IGL-ETB-IRL1620
43.33Single8FEGPRD_0025178FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
42.86Single3NY8ICI 118-5513NY8-β2-ICI 118-551
42.86Single4GBR(S)-Carazolol4GBR-β2-(S)-Carazolol
42.86Single5JQH(S)-Carazolol5JQH-β2-(S)-Carazolol
42.86Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
42.86Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
42.86Single6PS0(S)-Carazolol6PS0-β2-(S)-Carazolol
42.86Single6PS1Timolol6PS1-β2-Timolol
42.86Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
42.86Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
42.86Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
42.86Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
42.86Single7LJCPubChem 867641037LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
42.86Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
42.86Single7UL4Alvimopan7UL4-μ-Alvimopan
42.86Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
42.86Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
42.86Single8GE3Epinephrine8GE3-β2-Epinephrine-Gs/&β;1/&γ;2
42.86Single8GEBEpinephrine8GEB-β2-Epinephrine-Gs/&β;1/&γ;2
42.86Single8GEEEpinephrine8GEE-β2-Epinephrine-Gs/&β;1/&γ;2
42.86Single8GFWEpinephrine8GFW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
42.86Single8GFXEpinephrine8GFX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
42.86Single8GFYEpinephrine8GFY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
42.86Single8GFZEpinephrine8GFZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
42.86Single8GG0Epinephrine8GG0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
42.86Single8GG1Epinephrine8GG1-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
42.86Single8GG2Epinephrine8GG2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
42.86Single8GG6Epinephrine8GG6-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
42.86Single8GGBEpinephrine8GGB-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
42.86Single8GGJEpinephrine8GGJ-β2-Epinephrine
42.86Single8GGNEpinephrine8GGN-β2-Epinephrine
42.86Single8GGOEpinephrine8GGO-β2-Epinephrine
42.86Single8GGUEpinephrine8GGU-β2-Epinephrine
42.86Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
42.86Single8UNMEpinephrine8UNM-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
42.86Single8UNNEpinephrine8UNN-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
42.86Single8UNPEpinephrine8UNP-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
42.86Consensusadrenergic_onOrthosteric Ligandbeta_on alpha_on
42.86Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
42.86Consensusdopamine_onOrthosteric Ligandd3_on d2_on d5_on d1_on
42.86Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
42.42Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
42.42Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
42.42Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
42.31Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
42.31Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
42.31Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
42.31Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
42.31Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
42.31Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
42.31Consensuscx3cr_onOrthosteric Ligandcx3cr1_on
42.31Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
42.11Single8GEIEpinephrine8GEI-β2-Epinephrine-Gs/&β;1/&γ;2
42.11Single8GGCEpinephrine8GGC-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
42.11Single8GGEEpinephrine8GGE-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
42.11Single8GH1Epinephrine8GH1-β2-Epinephrine
41.94Single5GLHEndothelin-15GLH-ETB-Endothelin-1
41.94Single6IGKEndothelin-36IGK-ETB-Endothelin-3
41.67Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
41.67Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
41.67Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
41.67Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
41.67Single6DDFDamgo6DDF-μ-Damgo-Gi1/&β;1/&γ;2
41.67Single7EZCUKA7EZC-A2A-UKA
41.67Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
41.67Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
41.67Single7XJISolabegron7XJI-β3-Solabegron-Gs/&β;1/&γ;2
41.67Single7XK2MK68927XK2-HCA2-MK6892-Gi1/&β;1/&γ;2
41.67Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
41.67Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
41.67Consensusbeta1_off_alloOrthosteric Ligand4BVN-β1-Cyanopindolol-Na
41.67Consensusgs_orexinOrthosteric Ligand7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
41.67Consensusorexin_onOrthosteric Ligandox2_on
41.38Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
41.38Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
40.91Single2RH1(S)-Carazolol2RH1-β2-(S)-Carazolol
40.91Single2YCW(S)-Carazolol2YCW-β1-(S)-Carazolol
40.91Single5D6L(S)-Carazolol5D6L-β2-(S)-Carazolol
40.91Single5N2SPSB365N2S-A1-PSB36
40.91Single6DDEDamgo6DDE-μ-Damgo-Gi1/&β;1/&γ;2
40.91Single6GDGNECA6GDG-A2A-NECA-Gs/&β;1/&γ;1
40.91Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
40.91Single6PS3(S)-Carvedilol6PS3-β2-(S)-Carvedilol
40.91Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
40.91Single7BVQ(S)-Carazolol7BVQ-β1-(S)-Carazolol
40.91Single7CKXA776367CKX-D1-A77636-Gs/&β;1/&γ;2
40.91Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2
40.91Single7SBFPZM217SBF-μ-PZM21-Gi1/&β;1/&γ;2
40.91Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
40.91Single7WC6LSD7WC6-5-HT2A-LSD
40.91Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
40.91Single8ID9Eicosapentaenoic acid8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
40.91Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
40.91Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
40.91Consensusa2a_onOrthosteric Ligand6GDG-A2A-NECA-Gs/&β;1/&γ;1
40.91Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
40.91Consensusamine_offOrthosteric Ligandadrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
40.91Consensusbeta2_offOrthosteric Ligand6PS2-β2-(S)-Alprenolol 6PS3-β2-(S)-Carvedilol 6PS5-β2-(S)-Propranolol 6PS6-β2-Timolol 2RH1-β2-(S)-Carazolol 6PS4-β2-ICI 118-551 3NY9-β2-PubChem 913103
40.91Consensusbeta2_onOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
40.91Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
40.91Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRR-D1-Rotigotine-Gs/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
40.91Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
40.91Consensusgi_adrenergicOrthosteric Ligand7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
40.91Consensusgs_adrenergicOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJI-β3-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
40.91Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
40.74Single5WF5UK-4320975WF5-A2A-UK-432097
40.74Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
40.74Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
40.74Consensuscx3cr1_onOrthosteric Ligand7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
40.00Single3VGAZM2413853VGA-A2A-ZM241385-Antibody
40.00Single5WF6UK-4320975WF6-A2A-UK-432097
40.00Single6AKXA4R6AKX-CCR5-A4R
40.00Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/&β;1/&γ;2
40.00Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
40.00Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
40.00Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
40.00Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
40.00Single7XN9L-054,5227XN9-SST2-L-054,522
40.00Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2
40.00Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
40.00Single8EFOPZM218EFO-μ-PZM21-Gi1/&β;1/&γ;2
40.00Single8GECEpinephrine8GEC-β2-Epinephrine-Gs/&β;1/&γ;2
40.00Single8GEFEpinephrine8GEF-β2-Epinephrine-Gs/&β;1/&γ;2
40.00Single8GG9Epinephrine8GG9-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
40.00Single8GGAEpinephrine8GGA-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
40.00Single8GGFEpinephrine8GGF-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
40.00Single8GGVEpinephrine8GGV-β2-Epinephrine
40.00Single8GGWEpinephrine8GGW-β2-Epinephrine
40.00Single8GGXEpinephrine8GGX-β2-Epinephrine
40.00Single8GH0Epinephrine8GH0-β2-Epinephrine
40.00Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/&β;1/&γ;2
40.00Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
40.00Single8UNWEpinephrine8UNW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
40.00Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
40.00Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
40.00Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
40.00Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
40.00Consensusendothelin_onOrthosteric Ligandetb_on eta_on
40.00Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
40.00Consensuslpl_offOrthosteric Ligands1p_off lpa_off
40.00Consensuslpl_onOrthosteric Ligands1p_on lpa_on
40.00Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
39.29Single6JODAngiotensin II6JOD-AT2-Angiotensin II
39.29Single7C61Ergotamine7C61-5-HT1B-Ergotamine
39.29Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
39.29Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
39.29Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
39.29Consensusgi_somatostatinOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
39.29Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
39.13Single3P0GBI1671073P0G-β2-BI167107
39.13Single3SN6BI1671073SN6-β2-BI167107-Gs/&β;1/&γ;2
39.13Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
39.13Single5D5A(S)-Carazolol5D5A-β2-(S)-Carazolol
39.13Single5D5B(S)-Carazolol5D5B-β2-(S)-Carazolol
39.13Single6H7JIsoprenaline6H7J-β1-Isoprenaline
39.13Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
39.13Single6NI3BI1671076NI3-β2-BI167107-Gs/&β;1/&γ;2
39.13Single7CKYPW04647CKY-D1-PW0464-Gs/&β;1/&γ;2
39.13Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
39.13Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
39.13Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2
39.13Single7JV5SKF812977JV5-D1-SKF81297-Gs/&β;1/&γ;2
39.13Single7TUYGSK682753A7TUY-GPR183-GSK682753A
39.13Single7W6PW967W6P-α2a-W96-Go/&β;1/&γ;2
39.13Single7W7EW587W7E-α2a-W58-Go/&β;1/&γ;2
39.13Single8DZPmomSalB8DZP-κ-momSalB-Gi1/&β;1/&γ;2
39.13Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
39.13Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
39.13Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/&β;1/&γ;2
39.13Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
39.13Single8JXVClozapine8JXV-H4-Clozapine-Gi1/&β;1/&γ;2
39.13Consensus5ht5_offOrthosteric Ligand5ht5a_off
39.13Consensus5ht_offOrthosteric Ligand5ht2_off 5ht5_off 5ht1_off
39.13Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
39.13Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCZ-β1-Iodocyanopindolol
39.13Consensuscck_onOrthosteric Ligandccka_on cckb_on
39.13Consensusgi_amineOrthosteric Ligandgi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
39.13Consensusgi_ffaOrthosteric Ligand8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
39.13Consensusgs_compl-peptideOrthosteric Ligand8I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
39.13Consensusgs_ffaOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2 8GDB-EP4-PGE2-Gs/&β;1/&γ;2
39.13Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
38.71Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
38.71Consensusgs_endothelinOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
38.46Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
38.46Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
38.46Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
38.46Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
38.46Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
38.46Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
38.46Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
38.46Single8G59TUG-8918G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
38.46Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
38.46Consensussst2_onOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
38.46Consensussst_onOrthosteric Ligandsst2_on sst4_on
38.24Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
38.10Single2YDOAdenosine2YDO-A2A-Adenosine
38.10Single3UZCPubChem 1355666093UZC-A2A-PubChem 135566609
38.10Single4MBSMaraviroc4MBS-CCR5-Maraviroc
38.10Single4ZJCSB-6740424ZJC-OX1-SB-674042
38.10Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
38.10Single6PS5(S)-Propranolol6PS5-β2-(S)-Propranolol
38.10Single6TPGEMPA6TPG-OX2-EMPA
38.10Single7AROLUF58337ARO-A2A-LUF5833-Na
38.10Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
38.10Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
38.10Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
38.10Single7F0TDopamine7F0T-D1-Dopamine-Gs/&β;1/&γ;2
38.10Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/&β;1/&γ;2
38.10Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
38.10Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
38.10Single8GDZEpinephrine8GDZ-β2-Epinephrine-Gs/&β;1/&γ;2
38.10Single8GE1Epinephrine8GE1-β2-Epinephrine-Gs/&β;1/&γ;2
38.10Single8GE4Epinephrine8GE4-β2-Epinephrine-Gs/&β;1/&γ;2
38.10Single8GE6Epinephrine8GE6-β2-Epinephrine-Gs/&β;1/&γ;2
38.10Single8GE7Epinephrine8GE7-β2-Epinephrine-Gs/&β;1/&γ;2
38.10Single8GE8Epinephrine8GE8-β2-Epinephrine-Gs/&β;1/&γ;2
38.10Single8GE9Epinephrine8GE9-β2-Epinephrine-Gs/&β;1/&γ;2
38.10Single8GFVEpinephrine8GFV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
38.10Single8GG3Epinephrine8GG3-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
38.10Single8GG4Epinephrine8GG4-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
38.10Single8GG5Epinephrine8GG5-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
38.10Single8GG8Epinephrine8GG8-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
38.10Single8GGIEpinephrine8GGI-β2-Epinephrine
38.10Single8GGKEpinephrine8GGK-β2-Epinephrine
38.10Single8GGMEpinephrine8GGM-β2-Epinephrine
38.10Single8GGPEpinephrine8GGP-β2-Epinephrine
38.10Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
38.10Single8UNQEpinephrine8UNQ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
38.10Single8UNREpinephrine8UNR-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
38.10Single8UNSEpinephrine8UNS-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
38.10Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/&β;1/&γ;2
38.10Consensusd1_on_alloOrthosteric Ligand7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
38.10Consensusd3_onOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
38.10Consensusgs_tarOrthosteric Ligand8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
38.10Consensusox1_offOrthosteric Ligand6TOT-OX1-Lemborexant 6TP4-OX1-ACT-462206 6TP6-OX1-Filorexant 6V9S-OX1-GTPL11403 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ7-OX1-SB-334867 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant
38.10Consensusox2_offOrthosteric Ligand6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant
37.93Single7KH0Acyclovir triphosphate7KH0-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
37.93Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
37.93Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
37.93Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
37.93Consensusbk1_onOrthosteric Ligand7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
37.93Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
37.93Consensusgs_bradykininOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
37.50Single3D4STimolol Maleate3D4S-β2-Timolol Maleate
37.50Single4AMIBucindolol4AMI-β1-Bucindolol
37.50Single4LDEBI1671074LDE-β2-BI167107
37.50Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
37.50Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
37.50Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
37.50Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
37.50Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
37.50Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
37.50Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
37.50Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
37.50Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
37.50Single7XMTJ-21567XMT-SST4-J-2156-Gi1/&β;1/&γ;2
37.50Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
37.50Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
37.50Single8I95EP548I95-C3aB-EP54-Go/&β;1/&γ;2
37.50Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2
37.50Single8IJDMK68928IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
37.50Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
37.50Single8JJLOlodaterol8JJL-β2-Olodaterol
37.50Single8WU1KCA8WU1-CB1-KCA-Arrestin1
37.50Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
37.50Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
37.50Consensusdp_offOrthosteric Liganddp2_off
37.50Consensusgs_trhOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
37.50Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
37.50Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
37.04Single6HLOAprepitant6HLO-NK1-Aprepitant
37.04Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
37.04Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
37.04Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
37.04Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
37.04Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
37.04Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
37.04Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
37.04Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
36.84Single8GGREpinephrine8GGR-β2-Epinephrine
36.84Single8GGZEpinephrine8GGZ-β2-Epinephrine
36.67Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
36.67Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
36.67Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
36.67Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
36.67Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
36.67Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
36.67Consensusgi_neuromedinOrthosteric Ligand7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
36.67Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
36.67Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
36.36Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
36.36Single2Y04Salbutamol2Y04-β1-Salbutamol
36.36Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
36.36Single3NYA(S)-Alprenolol3NYA-β2-(S)-Alprenolol
36.36Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
36.36Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
36.36Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
36.36Single4QKXPubChem 762106284QKX-β2-PubChem 76210628
36.36Single4X1HNonyl Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
36.36Single5UENDU1725UEN-A1-DU172
36.36Single6H7MSalbutamol6H7M-β1-Salbutamol
36.36Single6PRZ(S)-Alprenolol6PRZ-β2-(S)-Alprenolol
36.36Single6PS2(S)-Alprenolol6PS2-β2-(S)-Alprenolol
36.36Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
36.36Single6TOTLemborexant6TOT-OX1-Lemborexant
36.36Single7BU7BI1671077BU7-β1-BI167107
36.36Single7CFMP3957CFM-GPBA-P395-Gs/&β;1/&γ;2
36.36Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
36.36Single7SCGFH2107SCG-μ-FH210-Gi1/&β;1/&γ;2
36.36Single7T2GMitragynine pseudoindoxyl7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
36.36Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
36.36Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2
36.36Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
36.36Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
36.36Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
36.36Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
36.36Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
36.36Single8CU6LJ-45178CU6-A2A-LJ-4517
36.36Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
36.36Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2
36.36Single8JJOAlprenolol8JJO-β2-Alprenolol
36.36Single8JLZST19368JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
36.36Single8UO4Epinephrine8UO4-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
36.36Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
36.36Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
36.36Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
36.36Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
36.36Consensusalpha2_onOrthosteric Ligandalpha2a_on alpha2b_on
36.36Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
36.36Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
36.36Consensusamine_onOrthosteric Ligandadrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on
36.36Consensusffa_onOrthosteric Ligandffa4_on ffa1_on ffa2_on ffa3_on
36.36Consensusgi_5htOrthosteric Ligand7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
36.36Consensusgi_hcaOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
36.36Consensusgi_hcarOrthosteric Ligandgi_hca
36.36Consensushca2_onOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
36.36Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
36.36Consensustar_onOrthosteric Ligandta1_on
36.00Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
36.00Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
36.00Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
36.00Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
36.00Single6H7LDobutamine6H7L-β1-Dobutamine
36.00Single6IBLArformoterol6IBL-β1-Arformoterol
36.00Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
36.00Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
36.00Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
36.00Single7UM4AS26747237UM4-5-HT5A-AS2674723
36.00Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
36.00Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/&β;1/&γ;2
36.00Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
36.00Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
36.00Single8E9YPubChem 4466038E9Y-M3-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
36.00Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
36.00Single8ID8TUG-8918ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
36.00Single8WRZ8D08WRZ-CB1-8D0-Arrestin1
36.00Consensus5ht5a_offOrthosteric Ligand7UM4-5-HT5A-AS2674723
36.00Consensusendothelin_offOrthosteric Ligandetb_off
36.00Consensusetb_offOrthosteric Ligand5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500 5X93-ETB-K-8794
36.00Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
36.00Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
35.71Single3OE0CVX153OE0-CXCR4-CVX15
35.71Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1
35.71Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
35.71Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
35.71Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
35.71Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
35.71Consensusgi_chemerinOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
35.71Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
35.48Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
35.48Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
35.48Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
35.48Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
35.48Consensusetb_onOrthosteric Ligand8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
35.48Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
35.29Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
35.00Single3PBLEticlopride3PBL-D3-Eticlopride
35.00Single6HLLCP999946HLL-NK1-CP99994
35.00Single6QNOAll-trans-retinal6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
35.00Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2
35.00Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/&β;1/&γ;2
35.00Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2
35.00Single8EF6Morphine8EF6-μ-Morphine-Gi1/&β;1/&γ;2
35.00Single8GGSEpinephrine8GGS-β2-Epinephrine
35.00Single8GGYEpinephrine8GGY-β2-Epinephrine
35.00Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2
35.00Single8IJANiacin8IJA-HCA2-Niacin-Gi1/&β;1/&γ;2
35.00Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
35.00Single8K5BNiacin8K5B-HCA2-Niacin
35.00Single8UNVEpinephrine8UNV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.00Single8UNXEpinephrine8UNX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.00Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
34.78Single2Y03Isoprenaline2Y03-β1-Isoprenaline
34.78Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
34.78Single5N2RPubChem 92460631; psb365N2R-A2A-PubChem 92460631; psb36-Na
34.78Single5NM2ZM2413855NM2-A2A-ZM241385-Na
34.78Single5TVNLSD5TVN-5-HT2B-LSD
34.78Single5WIUNemonapride5WIU-D4-Nemonapride
34.78Single5WIVNemonapride5WIV-D4-Nemonapride-Na
34.78Single5WQCEMPA5WQC-OX2-EMPA
34.78Single6E67BI1671076E67-β2-BI167107-Gs (fused)
34.78Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
34.78Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
34.78Single6PS6Timolol6PS6-β2-Timolol
34.78Single6TP6Filorexant6TP6-OX1-Filorexant
34.78Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
34.78Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
34.78Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
34.78Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
34.78Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
34.78Single7Y27Somatostatin-147Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
34.78Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
34.78Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
34.78Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
34.78Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
34.78Single8GNEKW-63568GNE-A2A-KW-6356-Na
34.78Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2
34.78Single8QOTNanobody E8QOT-μ-Nanobody E
34.78Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
34.78Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
34.78Consensusalpha2a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
34.78Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
34.78Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
34.78Consensuscb2_onOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
34.78Consensusd4_offOrthosteric Ligand5WIU-D4-Nemonapride
34.78Consensusd4_off_alloOrthosteric Ligand5WIV-D4-Nemonapride-Na
34.78Consensusgo_amineOrthosteric Ligandgo_adrenergic go_muscarinic go_5ht
34.78Consensusgs_sstOrthosteric Ligand7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
34.62Single5ZTYAM102575ZTY-CB2-AM10257
34.62Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
34.62Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
34.62Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
34.62Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
34.62Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
34.62Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
34.62Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
34.62Single8IYHMK68928IYH-HCA2-MK6892-Go/&β;1/&γ;2
34.62Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
34.62Single8X5YAstemizole8X5Y-H1-Astemizole
34.62Single8XZFWN5618XZF-Apelin-WN561-Gi1/&β;1/&γ;2
34.62Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2 8I95-C3aB-EP54-Go/&β;1/&γ;2
34.62Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
34.62Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
34.62Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
34.62Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
34.62Consensusmotilin_onOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
34.48Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
34.48Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
34.48Single8IHFMK68928IHF-HCA2-MK6892-Gi1/&β;1/&γ;2
34.48Single8J6IMK68928J6I-HCA2-MK6892-Gi1/&β;1/&γ;2
34.48Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
34.48Consensusnmur2_onOrthosteric Ligand7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
34.48Consensusnmur_onOrthosteric Ligandnmur1_on nmur2_on
34.38Single7VGXNeuropeptide Y7VGX-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
34.38Single8IY6Endothelin-18IY6-ETB-Endothelin-1
34.38Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
33.33Single2X72All-trans-retinal2X72-Rhodopsin-All-trans-retinal-Gt(CT)
33.33Single3PWHZM2413853PWH-A2A-ZM241385
33.33Single4AMJ(S)-Carvedilol4AMJ-β1-(S)-Carvedilol
33.33Single4DJHJDTic4DJH-κ-JDTic
33.33Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
33.33Single4XT1Fractalkine4XT1-US28-Fractalkine
33.33Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
33.33Single5K2DZM2413855K2D-A2A-ZM241385
33.33Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
33.33Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
33.33Single5V54Methiothepin5V54-5-HT1B-Methiothepin
33.33Single5WS3EMPA5WS3-OX2-EMPA
33.33Single5X93K-87945X93-ETB-K-8794
33.33Single6AKYMaraviroc6AKY-CCR5-Maraviroc
33.33Single6B73PubChem 1319551386B73-κ-PubChem 131955138
33.33Single6JZHZM2413856JZH-A2A-ZM241385-Na
33.33Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
33.33Single6KUXRS-799486KUX-α2a-RS-79948
33.33Single6OBA(S)-Alprenolol6OBA-β2-(S)-Alprenolol-GTPL11074
33.33Single6PS7ZM2413856PS7-A2A-ZM241385-Na
33.33Single6TODEMPA6TOD-OX1-EMPA-Na
33.33Single6TQ7SB-3348676TQ7-OX1-SB-334867
33.33Single6WGTLSD6WGT-5-HT2A-LSD
33.33Single7BR3Elagolix7BR3-GnRH1-Elagolix
33.33Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2
33.33Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2
33.33Single7EW7PubChem 40774607EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
33.33Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
33.33Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/&β;1/&γ;2
33.33Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
33.33Single7F8XNN90567F8X-CCKA-NN9056
33.33Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
33.33Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
33.33Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
33.33Single7TUZ7alpha,25-dihydroxycholesterol7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
33.33Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
33.33Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
33.33Single7WV9PubMed 1048957WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
33.33Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2
33.33Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
33.33Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
33.33Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
33.33Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
33.33Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
33.33Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
33.33Single8GEAEpinephrine8GEA-β2-Epinephrine-Gs/&β;1/&γ;2
33.33Single8GEDEpinephrine8GED-β2-Epinephrine-Gs/&β;1/&γ;2
33.33Single8GG7Epinephrine8GG7-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8GHVPubChem 1459649038GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
33.33Single8GNGIstradefylline8GNG-A2A-Istradefylline
33.33Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2
33.33Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
33.33Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
33.33Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Single8IW4Spermidine8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Single8IWESpermidine8IWE-TAAR9-Spermidine
33.33Single8J6RMK68928J6R-HCA2-MK6892-Gi1/&β;1/&γ;2
33.33Single8JXWVUF68848JXW-H4-VUF6884-Gi1/&β;1/&γ;2
33.33Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/&β;1/&γ;2
33.33Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Single8UNLEpinephrine8UNL-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8UNOEpinephrine8UNO-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8UNTEpinephrine8UNT-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8UNUEpinephrine8UNU-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8UO1Epinephrine8UO1-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
33.33Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
33.33Consensus5ht1_offOrthosteric Ligand5ht1b_off
33.33Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
33.33Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
33.33Consensusa2a_off_alloOrthosteric Ligand6ZDR-A2A-HMS1413f12-Na 6GT3-A2A-Imaradenant-Na 8CU7-A2A-LJ-4517-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PubChem 92460631; psb36-Na 5MZJ-A2A-Theophylline-Na 5OLO-A2A-Tozadenant-Na 5OLH-A2A-Vipadenant-Na 5NM4-A2A-ZM241385-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5MZP-A2A-Caffeine-Na 8CIC-A2A-Etrumadenant-Na
33.33Consensusadenosine_offOrthosteric Liganda1_off a2_off
33.33Consensusalpha1_onOrthosteric Ligandalpha1a_on
33.33Consensusalpha1a_onOrthosteric Ligand7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Consensusalpha2_offOrthosteric Ligandalpha2a_off alpha2c_off
33.33Consensusalpha2a_offOrthosteric Ligand6KUX-α2a-RS-79948
33.33Consensusangiotensin_offOrthosteric Ligandat1_off at2_off
33.33Consensusbeta2_off_alloOrthosteric Ligand6OBA-β2-(S)-Alprenolol-GTPL11074
33.33Consensuscyslt1_off_ortoalloOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
33.33Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
33.33Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
33.33Consensusgo_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
33.33Consensusgs_neuromedinOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Consensush1_offOrthosteric Ligand3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole 8X63-H1-Mepyramine 8X64-H1-Desloratadine
33.33Consensushistamine_offOrthosteric Ligandh1_off
33.33Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
33.33Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
33.33Consensuslpa_offOrthosteric Ligandlpa1_off
33.33Consensuslpa_onOrthosteric Ligandlpa1_on
33.33Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Consensusnk1_offOrthosteric Ligand6J20-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
33.33Consensusnpy_offOrthosteric Ligandnpy2_off npy1_off
33.33Consensusorexin_offOrthosteric Ligandox2_off ox1_off
33.33Consensusp2y_offOrthosteric Ligandp2y1_off p2y12_off
33.33Consensussst4_onOrthosteric Ligand7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
32.35Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
32.14Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
32.14Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/&β;1/&γ;2
32.14Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
32.14Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
32.14Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
32.14Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
32.14Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
32.14Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
32.00Single4XEENeurotensin4XEE-NTS1-Neurotensin
32.00Single4XESNeurotensin4XES-NTS1-Neurotensin
32.00Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
32.00Single6A93Risperidone6A93-5-HT2A-Risperidone
32.00Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
32.00Single6H7N(S)-Xamoterol6H7N-β1-(S)-Xamoterol
32.00Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/&β;1/&γ;2
32.00Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/&β;1/&γ;2
32.00Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
32.00Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
32.00Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
32.00Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/&β;1/γ1
32.00Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
32.00Single7WCNAR2314537WCN-GPR119-AR231453-Gs/&β;1/&γ;2
32.00Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
32.00Single7Y66BM2137Y66-C5a1-BM213-Gi1/&β;1/&γ;2
32.00Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2
32.00Single8J6DEP1418J6D-C3aB-EP141-Go/&β;1/&γ;2
32.00Single8JPBNeurotensin 8-138JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
32.00Single8JWYPubChem 1684517108JWY-A2A-PubChem 168451710
32.00Single8JWZAB9288JWZ-A2A-AB928-Na
32.00Consensusat2_offOrthosteric Ligand7JNI-AT2-Olodanrigan
32.00Consensusbeta1_onOrthosteric Ligand7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
32.00Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
32.00Consensuscannabinoid_onOrthosteric Ligandcb1_on cb2_on
32.00Consensuscb1_onOrthosteric Ligand8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
32.00Consensusgi_cannabinoidOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
32.00Consensusleuko_offOrthosteric Ligandblt_off cyslt_off
32.00Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
32.00Consensustsh_on_alloOther Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
31.82Single5IU4ZM2413855IU4-A2A-ZM241385-Na
31.82Single5IU7Q274563465IU7-A2A-Q27456346-Na
31.82Single5IUBQ274563445IUB-A2A-Q27456344-Na
31.82Single5JTBZM2413855JTB-A2A-ZM241385
31.82Single5K2CZM2413855K2C-A2A-ZM241385-Na
31.82Single5NLXZM2413855NLX-A2A-ZM241385-Na
31.82Single5NM4ZM2413855NM4-A2A-ZM241385-Na
31.82Single6AQFZM2413856AQF-A2A-ZM241385
31.82Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
31.82Single6MH8ZM2413856MH8-A2A-ZM241385
31.82Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
31.82Single6V9SGTPL114036V9S-OX1-GTPL11403
31.82Single6VI4JDTic6VI4-κ-JDTic
31.82Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
31.82Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
31.82Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/&β;1/&γ;2
31.82Single7CMVPD1289077CMV-D3-PD128907-Gi1/&β;1/&γ;2
31.82Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
31.82Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
31.82Single7JOZVFP7JOZ-D1-VFP-Gs/&β;1/&γ;2
31.82Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
31.82Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
31.82Single8GGLEpinephrine8GGL-β2-Epinephrine
31.82Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2
31.82Single8GURPubChem 1048958GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2
31.82Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.82Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
31.82Single8JIMMMF8JIM-HCA2-MMF-Gi1/&β;1/&γ;2
31.82Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
31.82Single8JLNT1AM8JLN-TA1-T1AM-Gs/&β;1/&γ;2
31.82Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
31.82Single8K5CAcipimox8K5C-HCA2-Acipimox
31.82Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
31.82Single8UHBRO52563908UHB-TA1-RO5256390-Gs/&β;1/&γ;2
31.82Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
31.82Consensus5ht5_onOrthosteric Ligand5ht5a_on
31.82Consensus5ht5a_onOrthosteric Ligand7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
31.82Consensusalpha2b_onOrthosteric Ligand6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
31.82Consensusffa2_onOrthosteric Ligand8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
31.82Consensusgnrh_offOrthosteric Ligandgnrh1_off
31.82Consensush3_on_alloOrthosteric Ligand7F61-H3-PF-03654746-Cholesterol
31.82Consensushca_onOrthosteric Ligandhca2_on hca3_on
31.82Consensushcar_onOrthosteric Ligandhca_on
31.58Single3RFMCaffeine3RFM-A2A-Caffeine
31.58Single8A2OTheophylline8A2O-A2A-Theophylline-Na
31.58Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
31.58Consensushca2_on_alloOrthosteric Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
31.25Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
31.03Single6W25SHU91196W25-MC4-SHU9119-Ca
31.03Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
31.03Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;2
31.03Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
31.03Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
31.03Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
30.77Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2
30.77Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
30.77Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
30.77Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
30.77Single8GAGYVF8GAG-CB1-YVF-Gi1/&β;1/&γ;2
30.77Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/&β;1/&γ;2
30.77Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
30.77Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
30.77Consensuscckb_onOrthosteric Ligand7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
30.77Consensusffa4_on_alloOrthosteric Ligand8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
30.56Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
30.43Single2Y01Dobutamine2Y01-β1-Dobutamine
30.43Single2Y02Carmoterol2Y02-β1-Carmoterol
30.43Single3EMLZM2413853EML-A2A-ZM241385
30.43Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
30.43Single4EIYZM2413854EIY-A2A-ZM241385-Na
30.43Single5IU8Q274563475IU8-A2A-Q27456347-Na
30.43Single5K2AZM2413855K2A-A2A-ZM241385-Na
30.43Single5OLGZM2413855OLG-A2A-ZM241385-Na
30.43Single5UIGJ3.651.884G5UIG-A2A-J3.651.884G
30.43Single5VRAZM2413855VRA-A2A-ZM241385-Na
30.43Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
30.43Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
30.43Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
30.43Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
30.43Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2
30.43Single6LPJZM2413856LPJ-A2A-ZM241385-Na
30.43Single6LPKZM2413856LPK-A2A-ZM241385-Na
30.43Single6S0LZM2413856S0L-A2A-ZM241385
30.43Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
30.43Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
30.43Single7PYRPSB-21157PYR-A2A-PSB-2115
30.43Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/&β;1/&γ;2
30.43Single7V3ZPubMed 1048957V3Z-CB1-PubMed 104895
30.43Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/&β;1/&γ;2
30.43Single7WC7Lisuride7WC7-5-HT2A-Lisuride
30.43Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
30.43Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
30.43Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
30.43Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
30.43Single8EFQDamgo8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
30.43Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/&β;1/&γ;2
30.43Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
30.43Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
30.43Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2
30.43Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/&β;1/&γ;2
30.43Single8X64Desloratadine8X64-H1-Desloratadine
30.43Consensus5ht1a_onOrthosteric Ligand8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
30.43Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
30.43Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
30.43Consensusa2_offOrthosteric Liganda2a_off
30.43Consensusa2a_offOrthosteric Ligand8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 5UIG-A2A-J3.651.884G 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-PubChem 168451710 5K2D-A2A-ZM241385
30.43Consensuscb1_on_alloOrthosteric Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
30.43Consensusfsh_on_alloOther Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
30.43Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
30.43Consensusp2y12_offOrthosteric Ligand4NTJ-P2Y12-AZD1283 7PP1-P2Y12-Selatogrel
30.30Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
30.00Single3UZAGTPL92363UZA-A2A-GTPL9236
30.00Single6FUFAll-trans-retinal6FUF-Rhodopsin-All-trans-retinal-Go/&β;1/&γ;2
30.00Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
30.00Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
30.00Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
30.00Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/&β;1/&γ;2
30.00Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
30.00Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
30.00Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
30.00Single8J6QBeta-hydroxybutyrate8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
30.00Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
30.00Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.00Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
30.00Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
30.00Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
29.73Consensuspth_onOrthosteric Ligandpth1_on pth2_on
29.63Single7SK9CCX6627SK9-ACKR3-CCX662
29.63Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
29.63Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
29.63Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.63Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
29.63Consensusgo_vasopressinOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
29.63Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
29.41Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
29.41Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
29.41Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
29.17Single2Y00Dobutamine2Y00-β1-Dobutamine
29.17Single4NTJAZD12834NTJ-P2Y12-AZD1283
29.17Single5IUAQ274563485IUA-A2A-Q27456348-Na
29.17Single6D26Fevipiprant6D26-DP2-Fevipiprant
29.17Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
29.17Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
29.17Single6LPLZM2413856LPL-A2A-ZM241385-Na
29.17Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
29.17Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
29.17Single6S0QZM2413856S0Q-A2A-ZM241385
29.17Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
29.17Single6WQAZM2413856WQA-A2A-ZM241385-Na
29.17Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
29.17Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
29.17Single7RM5ZM2413857RM5-A2A-ZM241385-Na
29.17Single7SINNPS-21437SIN-CaS-NPS-2143
29.17Single7SINNPS-21437SIN-CaS-NPS-2143
29.17Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
29.17Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
29.17Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
29.17Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
29.17Single8FN1Neurotensin/neuromedin N8FN1-NTS1-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
29.17Single8FYNZM2413858FYN-A2A-ZM241385-Na
29.17Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
29.17Single8J19PubChem 1270454228J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
29.17Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
29.17Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
29.17Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
29.17Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
29.17Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
29.17Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide 6DRX-5-HT2B-Lisuride
29.17Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
29.03Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
29.03Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.03Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
29.03Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
29.03Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
29.03Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
29.03Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.03Consensusgs_melanocortinOrthosteric Ligand7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2
28.57Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
28.57Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
28.57Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
28.57Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
28.57Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
28.57Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/&β;1/&γ;1
28.57Single7QA8Peptide7QA8-STE2-Peptide
28.57Single7QA8Peptide7QA8-STE2-Peptide
28.57Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
28.57Single7SRQLSD7SRQ-5-HT2B-LSD
28.57Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
28.57Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
28.57Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2
28.57Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/&β;1/&γ;2
28.57Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
28.57Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
28.57Single8IY9Niacin8IY9-HCA2-Niacin-Go/&β;1/&γ;2
28.57Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
28.57Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
28.57Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
28.57Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/&β;1/&γ;2
28.57Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
28.57Consensus5ht4_onOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
28.57Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
28.57Consensusclass-d_offOrthosteric Ligandste2_off
28.57Consensusfpr-alx_onOrthosteric Ligandfpr1-alx_on fpr2-alx_on
28.57Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
28.57Consensusglp_onOrthosteric Ligandglp1_on glp2_on
28.57Consensusnmur1_onOrthosteric Ligand7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.57Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
28.57Consensusox1_off_alloOrthosteric Ligand6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na 6TO7-OX1-Suvorexant-Na
28.21Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
28.21Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
28.12Single4XT3Fractalkine4XT3-US28-Fractalkine
28.12Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
28.12Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
28.12Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
28.12Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.12Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
28.12Consensusbb1_onOrthosteric Ligand8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.00Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
28.00Single4BV0Neurotensin4BV0-NTS1-Neurotensin
28.00Single4U15Tiotropium4U15-M3-Tiotropium
28.00Single5XR8AM8415XR8-CB1-AM841
28.00Single5XRAAM115425XRA-CB1-AM11542
28.00Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
28.00Single6J20Aprepitant6J20-NK1-Aprepitant
28.00Single6OL9Tiotropium6OL9-M5-Tiotropium
28.00Single6OS1TRV0266OS1-AT1-TRV026
28.00Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
28.00Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2
28.00Single7F1TMIP-1a7F1T-CCR5-MIP-1a
28.00Single7FEEPubMed 1048957FEE-CB1-PubMed 104895-ZCZ011
28.00Single7PX4PSB-21137PX4-A2A-PSB-2113
28.00Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2
28.00Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
28.00Single7XOWGastrin7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
28.00Single7XOXCholecystokinin-87XOX-CCKB-Cholecystokinin-8-Gq/&β;1/&γ;2
28.00Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2
28.00Single8EFLSR170188EFL-μ-SR17018-Gi1/&β;1/&γ;2
28.00Single8FMZNeurotensin/neuromedin N8FMZ-NTS1-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
28.00Single8G056-OAU8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
28.00Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
28.00Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2
28.00Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2
28.00Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/&β;1/&γ;2
28.00Single8JD0J9R8JD0-mGlu2; mGlu3-Glutamate-J9R
28.00Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
28.00Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
28.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
28.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
28.00Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
28.00Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
28.00Consensuschemerin_onOrthosteric Ligandcml1_on
28.00Consensuscml1_onOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
28.00Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
28.00Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
28.00Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
28.00Consensusnts1_on_alloOrthosteric Ligand8JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
28.00Consensusrelaxin_onOrthosteric Ligandrxfp4_on
28.00Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
27.78Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
27.59Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
27.59Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
27.59Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.59Consensusalpha1_offOrthosteric Ligandalpha1a_off alpha1b_off
27.27Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
27.27Single4S0VSuvorexant4S0V-OX2-Suvorexant
27.27Single5DHHSB-6121115DHH-NOP-SB-612111
27.27Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
27.27Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
27.27Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
27.27Single6ME2Ramelteon6ME2-MT1-Ramelteon
27.27Single6NWEOctyl Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
27.27Single6OYAAll-trans-retinal6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
27.27Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
27.27Single6TPJSuvorexant6TPJ-OX2-Suvorexant
27.27Single7F8ULintitript7F8U-CCKA-Lintitript
27.27Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;1
27.27Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
27.27Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
27.27Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
27.27Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
27.27Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
27.27Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
27.27Single7W0OElabela7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
27.27Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
27.27Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
27.27Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
27.27Single7XRRLemborexant7XRR-OX2-Lemborexant
27.27Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2
27.27Single8HOCImetit8HOC-H4-Imetit-Gi1/&β;1/&γ;2
27.27Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2
27.27Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
27.27Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/&β;1/&γ;2
27.27Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
27.27Consensus5ht2_onOrthosteric Ligand5ht2a_on 5ht2c_on
27.27Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
27.27Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
27.27Consensusffa3_on_alloOrthosteric Ligand8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
27.27Consensusgi_histamineOrthosteric Ligand8HN8-H4-Histamine-Gi1/&β;1/&γ;2 8HOC-H4-Imetit-Gi1/&β;1/&γ;2
27.27Consensusgo_class-b1Orthosteric Ligandgo_crf
27.27Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
27.27Consensusgs_5htOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2 7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2 7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
27.27Consensusgs_histamineOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.27Consensusgt_class-aOrthosteric Ligandgt_opsin
27.27Consensusgt_opsinOrthosteric Ligandgt_sensory
27.27Consensusgt_sensoryOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
27.27Consensush4_onOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.27Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
27.27Consensusmelatonin_onOrthosteric Ligandmt1_on mt2_on
27.27Consensusmglu_onOther Ligandmglu2_on mglu4_on
27.03Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
27.03Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
26.92Single4GRVNeurotensin 8-134GRV-NTS1-Neurotensin 8-13
26.92Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
26.92Single5CXVTiotropium5CXV-M1-Tiotropium
26.92Single6CM4Risperidone6CM4-D2-Risperidone
26.92Single6HLPNetupitant6HLP-NK1-Netupitant
26.92Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
26.92Single6KQIPubMed 1048956KQI-CB1-PubMed 104895-ORG27569
26.92Single6OS2TRV0266OS2-AT1-TRV026
26.92Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
26.92Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
26.92Single6YVRNTS8-136YVR-NTS1-NTS8-13
26.92Single6ZG4HTL00099366ZG4-M1-HTL0009936
26.92Single7DFPSpiperone7DFP-D2-Spiperone
26.92Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2
26.92Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
26.92Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.92Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2
26.92Single8IBUErythromycin A8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.92Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
26.92Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
26.92Consensuscb1_off_alloOrthosteric Ligand6KQI-CB1-PubMed 104895-ORG27569
26.92Consensuschemokine_offOrthosteric Ligandcxcr_off
26.92Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II
26.92Consensuscxcr_offOrthosteric Ligandcxcr4_off
26.92Consensusgi_class-fOther Ligandgi_frizzled
26.92Consensusgi_frizzledOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
26.92Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
26.92Consensusnts1_onOrthosteric Ligand6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
26.92Consensusnts_onOrthosteric Ligandnts1_on
26.67Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
26.67Single7F4DAlpha-MSH7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
26.67Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.67Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
26.67Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
26.67Consensusgi_formylpeptideOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
26.47Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
26.47Single6LMLGlucagon6LML-Glucagon-Glucagon
26.47Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
26.47Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
26.47Consensuscrf1_onOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
26.32Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
26.32Single8GEJEpinephrine8GEJ-β2-Epinephrine-Gs/&β;1/&γ;2
26.32Single8PWNTheophylline8PWN-A2A-Theophylline
26.32Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
26.19Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
26.09Single3REYPubChem 56973REY-A2A-PubChem 5697
26.09Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
26.09Single5K2BZM2413855K2B-A2A-ZM241385-Na
26.09Single5TE3Octyl Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
26.09Single5UVIZM2413855UVI-A2A-ZM241385
26.09Single6A94Zotepine6A94-5-HT2A-Zotepine
26.09Single6DS0Ly2660976DS0-5-HT2B-Ly266097
26.09Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
26.09Single6IQLL7458706IQL-D4-L745870
26.09Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
26.09Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
26.09Single6TP3Nemorexant6TP3-OX1-Nemorexant
26.09Single6TPNHTL66416TPN-OX2-HTL6641
26.09Single6ZDVPubChem 9840736ZDV-A2A-PubChem 984073-Na
26.09Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
26.09Single7BB6Acyclovir triphosphate7BB6-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
26.09Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2
26.09Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
26.09Single7T32ZM2413857T32-A2A-ZM241385
26.09Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
26.09Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2
26.09Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
26.09Single7XOVSR1461317XOV-CCKA-SR146131-Gs/&β;1/&γ;2
26.09Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
26.09Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.09Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.09Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2
26.09Single8HQN9(S)-HODE8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
26.09Single8JERAcipimox8JER-HCA2-Acipimox-Go/&β;1/&γ;2
26.09Single8JHNMMF8JHN-HCA2-MMF-Go/&β;1/&γ;2
26.09Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2
26.09Single8K4NVF08K4N-GPR34-VF0-Gi1/&β;1/&γ;2
26.09Consensus5ht2a_onOrthosteric Ligand7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.09Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
26.09Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
26.09Consensuscxcr_onOrthosteric Ligandcxcr1_on cxcr2_on
26.09Consensusgi_melatoninOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
26.09Consensuslh_on_alloOther Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
26.09Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
26.09Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
26.09Consensuss1p_offOrthosteric Ligands1p1_off
25.93Single4BUONeurotensin4BUO-NTS1-Neurotensin
25.93Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
25.93Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
25.93Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
25.93Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
25.93Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
25.93Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.93Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
25.93Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
25.93Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
25.93Single7XZ6APD6687XZ6-GPR119-APD668-Gs/&β;1/&γ;2
25.93Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
25.93Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
25.93Consensusc5a1_off_ortoalloOrthosteric Ligand6C1Q-C5a1-PMX53-NDT9513727 6C1R-C5a1-PMX53-Avacopan; Na
25.93Consensusgi_neurotensinOrthosteric Ligand7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
25.93Consensusgs_lipidOrthosteric Ligandgs_ffa gs_prostanoid
25.93Consensusot_onOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
25.81Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
25.81Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
25.81Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
25.71Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
25.71Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
25.00Single4QIMPubChem 249053754QIM-SMO-PubChem 24905375
25.00Single4U16N-Methyl Scopolamine4U16-M3-N-Methyl Scopolamine
25.00Single4YAYZD-71554YAY-AT1-ZD-7155
25.00Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
25.00Single5DHGPubChem 250014125DHG-NOP-PubChem 25001412
25.00Single5EE7MK08935EE7-Glucagon-MK0893
25.00Single5TGZAM65385TGZ-CB1-AM6538
25.00Single5YC8N-Methyl Scopolamine5YC8-M2-N-Methyl Scopolamine
25.00Single5ZK8N-Methyl Scopolamine5ZK8-M2-N-Methyl Scopolamine
25.00Single5ZKCN-Methyl Scopolamine5ZKC-M2-N-Methyl Scopolamine
25.00Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
25.00Single6D27CAY104716D27-DP2-CAY10471
25.00Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
25.00Single6KNMJN241-96KNM-Apelin-JN241-9
25.00Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
25.00Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
25.00Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
25.00Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
25.00Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single7MTBAll-trans-retinal7MTB-Rhodopsin-All-trans-retinal-GRK1
25.00Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
25.00Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
25.00Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
25.00Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
25.00Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
25.00Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
25.00Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
25.00Single7VKTLTB47VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
25.00Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
25.00Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
25.00Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
25.00Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/&β;1/&γ;2
25.00Single8IWM2-Phenylethylamine8IWM-TAAR9-2-Phenylethylamine
25.00Single8J18(3R)-3-hydroxydodecanoic acid8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
25.00Single8K5DGSK2560738K5D-HCA2-GSK256073
25.00Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
25.00Single8SAI1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
25.00Single8WC5Tetramethylammonium ion8WC5-TA1-Tetramethylammonium ion-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single8X63Mepyramine8X63-H1-Mepyramine
25.00Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
25.00Consensusblt_onOrthosteric Ligandblt1_on
25.00Consensusbombesin_onOrthosteric Ligandbb2_on bb1_on
25.00Consensuscck_offOrthosteric Ligandccka_off
25.00Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
25.00Consensusclass-d_offOrthosteric Ligandste2_off
25.00Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
25.00Consensusfpr2-alx_onOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
25.00Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
25.00Consensusgo_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
25.00Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
25.00Consensushca3_onOrthosteric Ligand8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
25.00Consensushistamine_onOrthosteric Ligandh1_on h4_on
25.00Consensusleuko_onOrthosteric Ligandblt_on
25.00Consensusm2_on_alloOrthosteric Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
25.00Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
25.00Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
25.00Consensussensory_onOrthosteric Ligandopsin_on
25.00Consensustachykinin_offOrthosteric Ligandnk1_off
24.39Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
24.32Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
24.32Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
24.32Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
24.24Single6FJ3PTH6FJ3-PTH1-PTH
24.24Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
24.24Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
24.24Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
24.24Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
24.24Single7SK3CXCL127SK3-ACKR3-CXCL12
24.24Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
24.24Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
24.24Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
24.14Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
24.14Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
24.00Single5XPRBosentan5XPR-ETB-Bosentan
24.00Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
24.00Single5ZK3Quinuclidinyl benzilate hydrobromide5ZK3-M2-Quinuclidinyl benzilate hydrobromide
24.00Single6LUQHaloperidol6LUQ-D2-Haloperidol
24.00Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
24.00Single7C4SS1P7C4S-S1P3-S1P
24.00Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
24.00Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
24.00Single7YXAONO-54306087YXA-S1P5-ONO-5430608
24.00Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
24.00Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2
24.00Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
24.00Single8JPCNeurotensin 8-138JPC-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
24.00Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
24.00Consensusgs_muscarinicOrthosteric Ligand8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
24.00Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
24.00Consensusm2_offOrthosteric Ligand5ZKB-M2-AF-DX 384 5ZKC-M2-N-Methyl Scopolamine 5ZK3-M2-Quinuclidinyl benzilate hydrobromide
24.00Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.81Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
23.81Single5WKTOctyl Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
23.81Single6ME5Agomelatine6ME5-MT1-Agomelatine
23.81Single6ME9Ramelteon6ME9-MT2-Ramelteon
23.81Single7MT8All-trans-retinal7MT8-Rhodopsin-All-trans-retinal-GRK1
23.81Single7MT9All-trans-retinal7MT9-Rhodopsin-All-trans-retinal-GRK1
23.81Single7MTAAll-trans-retinal7MTA-Rhodopsin-All-trans-retinal-GRK1
23.81Single8EITDoconexent8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
23.81Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/&β;1/&γ;2
23.81Single8IW72-Phenylethylamine8IW7-TAAR9-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
23.81Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/&β;1/&γ;2
23.81Single8POKHistamine8POK-H2-Histamine-Gs/&β;1/&γ;2
23.81Consensusopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
23.68Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
23.68Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
23.68Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
23.53Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
23.53Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
23.53Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
23.53Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
23.33Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
23.33Single7SK5CXCL127SK5-ACKR3-CXCL12
23.26Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
23.08Single3UONQuinuclidinyl benzilate hydrobromide3UON-M2-Quinuclidinyl benzilate hydrobromide
23.08Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
23.08Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
23.08Single6E59L-7607356E59-NK1-L-760735
23.08Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
23.08Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
23.08Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
23.08Single7B6WCyclazosin7B6W-α1b-Cyclazosin
23.08Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2
23.08Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1
23.08Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/&β;1/&γ;1
23.08Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
23.08Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
23.08Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
23.08Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
23.08Single7W41PD1762527W41-BB2-PD176252
23.08Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
23.08Single8GUSHU-3088GUS-CB2-HU-308-Gi1/&β;1/&γ;2
23.08Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
23.08Consensusalpha1b_offOrthosteric Ligand7B6W-α1b-Cyclazosin
23.08Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
23.08Consensusbombesin_offOrthosteric Ligandbb2_off
23.08Consensusgi_muscarinicOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
23.08Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl Scopolamine 5ZHP-M3-PubChem 134828589
22.86Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
22.86Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
22.86Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
22.86Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
22.86Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
22.86Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
22.73Single3OE9IT1t3OE9-CXCR4-IT1t
22.73Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
22.73Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
22.73Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
22.73Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
22.73Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
22.73Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
22.73Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.73Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.73Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
22.73Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.73Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/&β;1/&γ;2
22.73Single8HN8Histamine8HN8-H4-Histamine-Gi1/&β;1/&γ;2
22.73Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2
22.73Single8ITFDMCHA8ITF-TAAR9-DMCHA-chim(NtGi1-Gs)/&β;1/&γ;2
22.73Single8JILNiacin8JIL-HCA2-Niacin-Gi1/&β;1/&γ;2
22.73Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
22.73Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
22.73Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
22.73Consensusmt1_onOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
22.73Consensusmt2_onOrthosteric Ligand7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
22.58Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
22.58Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.58Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
22.58Consensusmc5_onOrthosteric Ligand8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
22.58Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
22.22Single4N4WSANT-14N4W-SMO-SANT-1
22.22Single4PY02MeSATP4PY0-P2Y12-2MeSATP
22.22Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
22.22Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/&β;1/&γ;2
22.22Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
22.22Single7K15MKD0467K15-BLT1-MKD046-Na
22.22Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
22.22Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
22.22Single8GCPPGE28GCP-EP4-PGE2-Gi1/&β;1/&γ;2
22.22Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.22Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
22.22Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg3_on
22.22Consensusblt1_offOrthosteric Ligand7K15-BLT1-MKD046-Na
22.22Consensusblt_offOrthosteric Ligandblt1_off
22.22Consensusclass-b2_onOrthosteric Ligandadgrg_on
22.22Consensusgi_prostanoidOrthosteric Ligand8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GDC-EP3-PGE2-Gi1/&β;1/&γ;2 8GCM-EP4-L902688-Gi1/&β;1/&γ;2
22.22Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
22.22Consensusgpr119_onOrthosteric Ligand7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
22.22Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
22.22Consensusnts1_offOrthosteric Ligand6Z4Q-NTS1-SR142948A 6Z4S-NTS1-SR48692
22.22Consensusnts_offOrthosteric Ligandnts1_off
21.95Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
21.88Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
21.88Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
21.88Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
21.88Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
21.88Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
21.74Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
21.74Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
21.74Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
21.74Single3VG9ZM2413853VG9-A2A-ZM241385-Antibody
21.74Single5ZKQABT-4915ZKQ-PAF-ABT-491
21.74Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
21.74Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
21.74Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
21.74Single7F8YDevazepide7F8Y-CCKA-Devazepide
21.74Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
21.74Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
21.74Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
21.74Single8FN0Neurotensin/neuromedin N8FN0-NTS1-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
21.74Single8IHKAcifran8IHK-HCA3-Acifran
21.74Consensus5ht2c_onOrthosteric Ligand8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.74Consensusm2_on_alloOther Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
21.62Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
21.43Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
21.43Single6K1QIRL25006K1Q-ETB-IRL2500
21.43Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
21.43Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.43Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.43Consensusep4_onOrthosteric Ligand7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2
21.43Consensusfpa_onOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.43Consensusgs_prostanoidOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.43Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.21Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
21.21Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
21.21Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
21.21Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
21.21Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
21.05Single5MZPCaffeine5MZP-A2A-Caffeine-Na
21.05Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
21.05Single8WCCCyclohexylammonium ion8WCC-TA1-Cyclohexylammonium ion
20.83Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
20.83Single3RZECidoxepin3RZE-H1-Cidoxepin
20.83Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
20.83Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
20.83Single6TPKRetosiban6TPK-OT-Retosiban
20.83Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
20.83Single6ZG9GSK10347026ZG9-M1-GSK1034702
20.83Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
20.83Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
20.83Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
20.83Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
20.83Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
20.83Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.83Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6WH4-5-HT2A-Methiothepin 7VOE-5-HT2A-Aripiprazole 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 6A93-5-HT2A-Risperidone
20.83Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
20.83Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
20.83Consensusm1_off_alloOrthosteric Ligand6WJC-M1-Atropine-Muscarinic toxin 7
20.83Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
20.83Consensussensory_offOrthosteric Ligandopsin_off
20.83Consensusvasopressin-ot_offOrthosteric Ligandot_off
20.69Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
20.69Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.69Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
20.69Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.69Consensusgs_bombesinOrthosteric Ligand8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.69Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
20.59Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
20.59Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/&β;1/&γ;2
20.59Single7D3SSecretin7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
20.59Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
20.59Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
20.59Consensusclass-d_onOrthosteric Ligandste2_on
20.00Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
20.00Single3PXOAll-trans-retinal3PXO-Rhodopsin-All-trans-retinal
20.00Single4DAJTiotropium4DAJ-M3-Tiotropium
20.00Single4MQSIperoxo4MQS-M2-Iperoxo
20.00Single4U14Tiotropium4U14-M3-Tiotropium
20.00Single5DSGTiotropium5DSG-M4-Tiotropium
20.00Single5DYSAll-trans-retinal5DYS-Rhodopsin-All-trans-retinal
20.00Single6DRXLisuride6DRX-5-HT2B-Lisuride
20.00Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
20.00Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
20.00Single6GPSMK08126GPS-CCR2-MK0812
20.00Single6IIVDaltroban6IIV-TP-Daltroban
20.00Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
20.00Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
20.00Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
20.00Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
20.00Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
20.00Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
20.00Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
20.00Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
20.00Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
20.00Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
20.00Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
20.00Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/&β;1/&γ;2
20.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
20.00Consensusgabab_offOther Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
20.00Consensusgi_class-dOrthosteric Ligandgi_ste
20.00Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
20.00Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
20.00Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
20.00Consensusm4_on_alloOrthosteric Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
20.00Consensusprostanoid_offOrthosteric Ligandep_off tp_off dp_off
20.00Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
20.00Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
20.00Consensustp_offOrthosteric Ligand6IIV-TP-Daltroban 6IIU-TP-Ramatroban
19.44Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
19.44Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
19.35Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
19.35Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
19.23Single4PHUFasiglifam4PHU-FFA1 (GPR40)-Fasiglifam
19.23Single5CGCHTL142425CGC-mGlu5-HTL14242
19.23Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
19.23Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
19.23Single6GPXMK08126GPX-CCR2-MK0812
19.23Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
19.23Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
19.23Single6Z4SSR486926Z4S-NTS1-SR48692
19.23Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
19.23Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
19.23Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2
19.23Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
19.23Single8EA0Iperoxo8EA0-M3-Iperoxo
19.23Single8GDAL9026888GDA-EP4-L902688-Gs/&β;1/&γ;2
19.23Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
19.23Consensusep_offOrthosteric Ligandep4_off
19.05Single6OY9All-trans-retinal6OY9-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
19.05Single6TQ9SB-4081246TQ9-OX1-SB-408124
19.05Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
18.92Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
18.92Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
18.92Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
18.92Consensusgs_crfOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
18.60Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
18.52Single5TZR-5TZR-FFA1 (GPR40)-MK8666
18.52Single5V56TC1145V56-SMO-TC114
18.52Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
18.52Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
18.52Single7EPENAM5637EPE-mGlu-NAM563
18.52Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
18.52Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.52Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.52Single8X79MRE-2698X79-I2-MRE-269-Gs/&β;1/&γ;2
18.18Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
18.18Single3OE6IT1t3OE6-CXCR4-IT1t
18.18Single3PQRAll-trans-retinal3PQR-Rhodopsin-All-trans-retinal-Gt(CT)
18.18Single4XNWMRS25004XNW-P2Y1-MRS2500
18.18Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
18.18Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
18.18Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
18.18Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
18.18Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
18.18Single7WC5Psilocin7WC5-5-HT2A-Psilocin
18.18Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.18Single8F76-8F76-OR51E2-Gs/&β;1/&γ;2
18.18Consensusclass-d_onOrthosteric Ligandste2_on
18.18Consensusgi_class-dOrthosteric Ligandgi_ste
18.18Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
18.18Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
18.18Consensussmo_off_alloOrthosteric Ligand6D32-SMO-Cyclopamine-Cyclopamine
18.18Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
17.86Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
17.86Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
17.86Single6IIURamatroban6IIU-TP-Ramatroban
17.86Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
17.86Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/&β;1/&γ;2
17.86Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
17.86Consensusep_onOrthosteric Ligandep4_on ep2_on ep3_on
17.86Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
17.86Consensusprostanoid_onOrthosteric Ligandep_on fpa_on
17.50Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
17.39Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
17.39Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
17.39Single2G87All-trans-retinal2G87-Rhodopsin-All-trans-retinal
17.39Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
17.39Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
17.39Single5L7IVismodegib5L7I-SMO-Vismodegib
17.39Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
17.39Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
17.39Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
17.39Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
17.39Single6TP4ACT-4622066TP4-OX1-ACT-462206
17.39Single7UL2SR486927UL2-NTS1-SR48692-Na
17.39Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
17.39Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
17.39Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
17.39Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
17.39Consensusclass-t_onOrthosteric Ligandtaste2_on
17.39Consensusgs_class-tOrthosteric Ligandgs_taste
17.39Consensusgs_tasteOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
17.39Consensusnts1_off_alloOrthosteric Ligand7UL2-NTS1-SR48692-Na
17.39Consensustaste2_onOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
17.24Single5CGDHTL142425CGD-mGlu5-HTL14242
17.24Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
17.24Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
17.24Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.24Consensuscyslt2_offOrthosteric Ligand6RZ6-CysLT2-ONO-2570366 6RZ9-CysLT2-ONO-2770372 6RZ8-CysLT2-ONO-2080365
17.24Consensuscyslt_offOrthosteric Ligandcyslt2_off
17.14Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
17.14Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
17.14Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
16.67Single3ODUIT1t3ODU-CXCR4-IT1t
16.67Single4BWBNeurotensin4BWB-NTS1-Neurotensin
16.67Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
16.67Single5U09Taranabant5U09-CB1-Taranabant
16.67Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
16.67Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
16.67Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
16.67Single6WWZCCL206WWZ-CCR6-CCL20-Go/&β;1/&γ;2
16.67Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
16.67Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
16.67Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
16.67Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
16.67Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
16.67Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
16.67Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
16.67Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
16.67Single8A6CAll-trans-retinal8A6C-Rhodopsin-All-trans-retinal
16.67Single8A6DAll-trans-retinal8A6D-Rhodopsin-All-trans-retinal
16.67Single8A6EAll-trans-retinal8A6E-Rhodopsin-All-trans-retinal
16.67Single8HMPPubChem 699214798HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
16.67Single8INRAlpha-MSH8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
16.67Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
16.67Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
16.67Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
16.67Consensusclass-f_offOrthosteric Ligandsmo_off
16.67Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
16.67Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
16.67Consensusgs_adgrOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Consensusgs_class-b2Orthosteric Ligandgs_adgr
16.67Consensusopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
16.22Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
16.22Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
16.22Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
16.22Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
16.13Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
16.13Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
16.13Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
16.13Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
16.13Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
16.00Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
16.00Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
16.00Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
16.00Single6ZINSR486926ZIN-NTS1-SR48692
16.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
16.00Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
16.00Single7VV6C48/807VV6-MRGPRX2-C48/80
16.00Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
16.00Single8GCML9026888GCM-EP4-L902688-Gi1/&β;1/&γ;2
16.00Single8K2WAMG4878K2W-CXCR3-AMG487
16.00Single8T3VDHA8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.00Consensusm1_off_alloOther Ligand6WJC-M1-Atropine-Muscarinic toxin 7
15.62Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
15.56Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
15.38Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
15.38Single5T04Neurotensin5T04-NTS1-Neurotensin
15.38Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
15.38Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
15.38Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
15.38Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
15.38Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
15.38Single8EJCTAK-8758EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
15.38Single8EJKTAK-8758EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
15.38Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-alpha-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
15.38Consensusffa1_onOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.38Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
15.38Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
15.38Consensushcar_offOrthosteric Ligandsuccinate_off
15.38Consensussmo_offOrthosteric Ligand5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
15.38Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
15.15Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
15.15Single7XNACYN1548067XNA-SST2-CYN154806
15.15Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
15.00Single4A4MAll-trans-retinal4A4M-Rhodopsin-All-trans-retinal-Gt(CT)
15.00Single5EN0All-trans-retinal5EN0-Rhodopsin-All-trans-retinal-Gt(CT)
15.00Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
15.00Single8WCBCyclohexylammonium ion8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.81Single4JKVTaladegib (LY2940680)4JKV-SMO-Taladegib (LY2940680)
14.81Single4WW3All-trans-retinal4WW3-Rhodopsin-All-trans-retinal
14.81Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
14.81Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
14.81Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
14.81Single8GDCPGE28GDC-EP3-PGE2-Gi1/&β;1/&γ;2
14.81Consensusccr2_off_alloOther Ligand5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
14.81Consensusep3_onOrthosteric Ligand8GDC-EP3-PGE2-Gi1/&β;1/&γ;2
14.29Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
14.29Single5V57TC1145V57-SMO-TC114
14.29Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2
14.29Single7P2L4YI7P2L-mGlu5-4YI
14.29Single7WC4Serotonin7WC4-5-HT2A-Serotonin
14.29Single7XKEBetahydroxyandrosterone7XKE-ADGRG2-Betahydroxyandrosterone-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Single8GDBPGE28GDB-EP4-PGE2-Gs/&β;1/&γ;2
14.29Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/&β;1/&γ;2
14.29Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
14.29Consensusclass-c_onOther Ligandgabab_on mglu_on
14.29Consensusmglu2_onOther Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
14.29Consensuss1p2_onOrthosteric Ligand7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
13.89Consensusghrh_onOrthosteric Ligand7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
13.79Single5X33BIIL2605X33-BLT1-BIIL260
13.79Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
13.79Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1
13.79Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
13.79Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.64Single2HPYAll-trans-retinal2HPY-Rhodopsin-All-trans-retinal
13.64Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/&β;1/&γ;2
13.51Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
13.33Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2
13.33Consensusadgrg2_onOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
13.33Consensusep2_onOrthosteric Ligand7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
13.33Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.33Consensusgs_galaninOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.04Single3OE8IT1t3OE8-CXCR4-IT1t
13.04Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
13.04Single6LI0GTPL98046LI0-GPR52-GTPL9804
13.04Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
13.04Single7S8O(R)-Zinc-35737S8O-MRGPRX2-(R)-Zinc-3573-Gi1/&β;1/&γ;2
13.04Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
12.50Single3AYMAll-trans-retinal3AYM-Rhodopsin-All-trans-retinal
12.50Single4O9RCyclopamine4O9R-SMO-Cyclopamine
12.50Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
12.50Single7S8N(R)-Zinc-35737S8N-MRGPRX2-(R)-Zinc-3573-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.50Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
12.50Consensusgo_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
12.50Consensusgo_proteinOrthosteric Ligandgo_chemokine
12.50Consensusm4_on_alloOther Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
12.50Consensussmo_on_alloOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
12.12Consensussst_offOrthosteric Ligandsst2_off
12.00Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
12.00Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
12.00Single4QINSAG1.54QIN-SMO-SAG1.5
12.00Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
12.00Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
12.00Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
12.00Single8U8FPML8U8F-GPR3-PML-Gs/&β;1/&γ;2
11.54Single6FFIMMPEP6FFI-mGlu5-MMPEP
11.54Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
11.54Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
11.54Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.54Single7VODCariprazine7VOD-5-HT2A-Cariprazine
11.54Single7XJJGalanin7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
11.54Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
11.54Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
11.54Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
11.54Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/&β;1/&γ;2
11.54Consensusgi_class-fOrthosteric Ligandgi_frizzled
11.54Consensusgi_frizzledOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
11.54Consensusgo_galaninOrthosteric Ligand7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
11.43Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
11.11Single6FFHFenobam6FFH-mGlu5-Fenobam
11.11Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
11.11Single7F83PF-051904577F83-Ghrelin-PF-05190457
11.11Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
10.34Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.34Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
10.34Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
10.26Consensuscalcitonin_onOrthosteric Ligandct_on ctlike_on
10.00Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
10.00Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
9.68Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/&β;1/&γ;2
9.68Single7CX2PGE27CX2-EP2-PGE2-Gs/&β;1/&γ;2
9.09Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
9.09Single8HSCFab0468HSC-GPR20-Fab046-Gi1/&β;1/&γ;2
8.82Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.70Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
8.70Single7VDMSubstance P7VDM-MRGPRX2-Substance P-Gi1/&β;1/&γ;2
8.70Single7XKDBetahydroxyandrosterone7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
8.70Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/&β;1/&γ;2
8.33Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/&β;1/&γ;2
8.00Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
8.00Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
8.00Single8X2K5YM8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
8.00Consensusgo_adhesionOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
8.00Consensusgo_class-b2Orthosteric Ligandgo_adhesion
7.69Single8DWHCompound-168DWH-MRGPRX1-Compound-16-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.69Consensussmo_on_alloOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
7.41Single7VVOPTH7VVO-PTH1-PTH-Gs/&β;1/&γ;2
7.14Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/&β;1/&γ;2
6.90Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
6.45Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.45Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.12Consensusgs_ctOrthosteric Ligand7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
5.71Single7SHEPI; PE7SHE-GPR158-PI; PE
5.26Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
5.26Single6D35Cholesterol6D35-SMO-Cholesterol
5.26Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
5.26Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
5.26Single6UO8SKF975416UO8-GABAB1, GABAB2-SKF97541-GS39783
5.26Single6UO9SKF975416UO9-GABAB1, GABAB2-SKF97541
5.26Single6W2XPubChem 53110426W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
5.26Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
5.26Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
5.26Single7C7QBaclofen7C7Q-GABAB1, GABAB2-Baclofen-PubChem 7023848
5.26Single7C7SCGP546267C7S-GABAB1, GABAB2-CGP54626
5.26Single7CUMCGP546267CUM-GABAB1, GABAB2-CGP54626-Phospholipid
5.26Single7DD5Ca37DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.26Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.26Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.26Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.26Single7DGEQuisqualate7DGE-mGlu1; mGlu1-Quisqualate
5.26Single7DTTCa7DTT-CaS-Ca-Ca
5.26Single7DTTCa7DTT-CaS-Ca-Ca
5.26Single7DTUTryptophan7DTU-CaS-Tryptophan
5.26Single7DTUTryptophan7DTU-CaS-Tryptophan
5.26Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
5.26Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
5.26Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
5.26Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
5.26Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.26Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.26Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.26Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.26Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
5.26Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
5.26Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
5.26Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
5.26Single7EB2Baclofen7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
5.26Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
5.26Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
5.26Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
5.26Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
5.26Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
5.26Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
5.26Single7FIHhCG7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
5.26Single7FIIhCG7FII-LH-hCG-6fuf
5.26Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
5.26Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
5.26Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
5.26Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
5.26Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.26Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.26Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.26Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.26Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
5.26Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
5.26Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
5.26Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
5.26Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
5.26Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
5.26Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
5.26Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
5.26Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
5.26Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
5.26Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.26Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.26Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.26Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.26Single7T9NM22 Fab7T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
5.26Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
5.26Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
5.26Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
5.26Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
5.26Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
5.26Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
5.26Single7XW6M22 Fab7XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
5.26Single7XW7K1-707XW7-TSH-K1-70
5.26Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
5.26Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
5.26Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
5.26Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
5.26Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
5.26Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
5.26Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
5.26Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
5.26Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
5.26Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
5.26Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
5.26Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
5.26Single8JD0Glutamate8JD0-mGlu2; mGlu3-Glutamate-J9R
5.26Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
5.26Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
5.26Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
5.26Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
5.26Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
5.26Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
5.26Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
5.26Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
5.26Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
5.26Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
5.26Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
5.26Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
5.26Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
5.26Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
5.26Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
5.26Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
5.26Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
5.26Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
5.26Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
5.26Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
5.26Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
5.26Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
5.26Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
5.26Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
5.26Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
5.26Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
5.26Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
5.26Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
5.26Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
5.26Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.26Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.26Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.26Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.26Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.26Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.26Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
5.26Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
5.26Consensusclass-c_offOrthosteric Ligandgabab_off mglu_off
5.26Consensusclass-c_offOrthosteric Ligandgabab_off mglu_off
5.26Consensusclass-c_offOther Ligandgabab_off mglu_off
5.26Consensusclass-c_onOrthosteric Ligandgabab_on mglu_on
5.26Consensusclass-c_onOrthosteric Ligandgabab_on mglu_on
5.26Consensusfsh_on_alloOrthosteric Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
5.26Consensusgabab_offOrthosteric Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
5.26Consensusgabab_onOrthosteric Ligand7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
5.26Consensusgi_class-cOrthosteric Ligandgi_mglu gi_gaba
5.26Consensusgi_class-cOrthosteric Ligandgi_mglu gi_gaba
5.26Consensusgi_gabaOrthosteric Ligand7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
5.26Consensusgi_mgluOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
5.26Consensusgi_mgluOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
5.26Consensusgphr_onOrthosteric Ligandlh_on tsh_on
5.26Consensusgs_gphrOrthosteric Ligand7T9I-TSH-TSH-Gs/&β;1/&γ;2 7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
5.26Consensusgs_proteinOrthosteric Ligandgs_gphr
5.26Consensuslh_onOrthosteric Ligand7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
5.26Consensuslh_on_alloOrthosteric Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
5.26Consensusmglu2_offOrthosteric Ligand7MTQ-mGlu2; mGlu2-LY341495
5.26Consensusmglu2_offOrthosteric Ligand7MTQ-mGlu2; mGlu2-LY341495
5.26Consensusmglu2_onOrthosteric Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
5.26Consensusmglu2_onOrthosteric Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
5.26Consensusmglu3_offOrthosteric Ligand7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
5.26Consensusmglu3_offOrthosteric Ligand7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
5.26Consensusmglu4_onOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
5.26Consensusmglu4_onOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
5.26Consensusmglu5_offOrthosteric Ligand7FD9-mGlu5; mGlu5-LY341495
5.26Consensusmglu5_offOrthosteric Ligand7FD9-mGlu5; mGlu5-LY341495
5.26Consensusmglu_offOrthosteric Ligandmglu2_off mglu3_off mglu5_off
5.26Consensusmglu_offOrthosteric Ligandmglu2_off mglu3_off mglu5_off
5.26Consensusmglu_onOrthosteric Ligandmglu2_on mglu4_on
5.26Consensusmglu_onOrthosteric Ligandmglu2_on mglu4_on
5.26Consensussmo_off_alloOther Ligand6D32-SMO-Cyclopamine-Cyclopamine
5.26Consensustsh_onOrthosteric Ligand7T9I-TSH-TSH-Gs/&β;1/&γ;2
5.26Consensustsh_on_alloOrthosteric Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
5.00Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
5.00Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
5.00Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
5.00Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
5.00Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
5.00Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
5.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
5.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
5.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
5.00Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
4.88Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
4.76Single7KNUCalcitonin gene-related peptide-17KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
4.76Single7T9MCS-17 Antibody7T9M-TSH-CS-17 Antibody
4.76Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
4.76Single7TYIAmylin7TYI-CT-Amylin-Gs/&β;1/&γ;2
4.76Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
4.76Single8HS2Fab0468HS2-GPR20-Fab046
4.65Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
4.55Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
4.55Single6W25Ca6W25-MC4-SHU9119-Ca
4.55Single7FIGhCG7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
4.55Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
4.55Single7UTZTR14027UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
4.55Single7XW5TSH7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
4.55Single7ZI0Cholesterol7ZI0-SMO-SAG-Cholesterol
4.55Single8F0KPramlintide analogue san3858F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
4.55Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
4.55Consensusccr8_offOrthosteric Ligand8TLM-CCR8-Anti-murine CCR8 antibody
4.44Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
4.44Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
4.35Single5L7DCholesterol5L7D-SMO-Cholesterol
4.35Single7T9ITSH7T9I-TSH-TSH-Gs/&β;1/&γ;2
4.35Single8I2GGlycoprotein hormones alpha chain8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
4.35Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
4.26Single8F2APramlintide analogue san3858F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
4.17Single7Y14Beta-alanine7Y14-MRGPRD-Beta-alanine
4.08Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
4.00Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
4.00Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2
4.00Single7Y12Beta-alanine7Y12-MRGPRD-Beta-alanine-Gi1/&β;1/&γ;2
4.00Single8F2BPramlintide analogue san458F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
4.00Consensusgip_on_alloOther Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
3.85Single7XKFBetahydroxyandrosterone7XKF-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
3.85Single8F0JPramlintide analogue san458F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2
3.57Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.57Single8IYXYL-3658IYX-GPR34-YL-365
3.45Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/&β;1/&γ;2
3.12Single7SHEPI; PE7SHE-GPR158-PI; PE
3.03Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
2.78Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
2.33Single7TYLAmylin7TYL-CT-Amylin-Gs/&β;1/&γ;2
2.33Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/&β;1/&γ;2; RAMP2

Consensus Members
Id Members
gs_amine gs_5ht
gs_adrenergic
gs_dopamine
gs_histamine
gs_muscarinic
gs_tar
gs_nucleotide gs_adenosine
gs_lipid gs_ffa
gs_prostanoid
gs_peptide gs_cck
gs_motilin
gs_neuromedin
gs_orexin
gs_sst
gs_tachykinin
gs_trh
gs_vasopressin-ot
gs_bombesin
gs_bradykinin
gs_compl-peptide
gs_endothelin
gs_galanin
gs_ghrelin
gs_melanocortin
gs_protein gs_gphr
gs_steroid gs_bileacid
Net Summary
Imin 3.01427
Number of Linked Nodes 1124
Number of Links 1285
Number of Hubs 185
Number of Links mediated by Hubs 766
Number of Communities 23
Number of Nodes involved in Communities 214
Number of Links involved in Communities 302
Path Summary
Number Of Nodes in MetaPath 99
Number Of Links MetaPath 98
Number of Shortest Paths 2235197
Length Of Smallest Path 3
Average Path Length 33.163
Length of Longest Path 62
Minimum Path Strength 0.148259
Average Path Strength 4.96023
Maximum Path Strength 28.79
Minimum Path Correlation 0.70054
Average Path Correlation 0.965005
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.66667
Average % Of Corr. Nodes 30.0858
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 47.1745
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .




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