Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
1R1.NT.R26 4.11254133
2R1.NT.F41 6.182518
3R1.NT.H44 7.2575417
4R1.NT.R55 5.784132
5R1.NT.C57 4.46408
6R1.NT.Y64 7.744504
7R1.NT.I66 4.6425406
8R1.NT.R68 8.55514
9R1.NT.V69 5.31405
10R1.NT.E70 7.168517
11R1.NT.M72 5.00667618
12R1.NT.H74 7.9825417
13R1.NT.T75 5.8075419
14R1.NT.R78 14.13418
15R1.NT.L85 5.82754296
16R1.NT.L86 4.145299
17R1.NT.I95 4.52167617
18R1.NT.R96 10.788504
19R1.NT.W100 7.0175403
20R1.NT.H101 3.87754274
21R1.NT.V104 5.244133
22R1.NT.E107 7.8254135
23R1.NT.I110 5.48754135
24R1.NT.R114 7.7525407
25R1.NT.L117 6.0454144
26R1.NT.P149 4.97167636
27R1.NT.V158 5.215435
28R1.NT.L162 4.296537
29R1.NT.Q169 5.89286738
30R1.NT.Y172 8.552517
31R1.NT.F185 6.584506
32R1.NT.Y187 9.0075407
33R1.NT.F188 8.07572738
34R1.NT.M189 4.55316
35R1.NT.R190 7.7775439
36R1.NT.P193 5.2448
37R1.NT.S194 3.755438
38R1.NT.Q198 8.0575449
39R1.NT.Y209 9.18478
40R1.NT.W211 8.048579
41R1.NT.Y213 4.24429709
42R1.NT.Y223 14.3825447
43R1.NT.Y246 8.51505
44R1.NT.F257 4.794324
45R1.NT.L261 5.8825155
46R1.NT.L264 7.654157
47R1.NT.T265 6.5485154
48R1.NT.L268 7.594154
49R1.NT.R272 10.8925405
50R1.NT.V273 8.2325478
51R1.NT.V274 4.594156
52R1.NT.F277 6.95747
53R1.NT.C278 4.01494
54R1.NT.V283 6.255495
55R1.NT.F299 7.6925157
56R1.NT.W307 6.778597
57R1.NT.V313 3.86667694
58R1.NT.Y317 7.6345333
59R1.NT.W336 12.555415
60R1.NT.F337 10.9025417
61R1.NT.Y341 8.262516
62R1.NT.R345 4.8954214
63R1.NT.P346 10.1954216
64R1.NT.E347 4.85754214
65R1.NT.N349 9.18414
66R1.NT.R351 8.5175414
67R1.NT.N352 7.57833617
68R1.NT.P353 5.345413
69R1.NT.W354 8.372515
70R1.NT.F355 7.385414
71R1.NT.F358 5.8975406
72R1.NT.W359 10.894217
73R1.NT.H361 5.434283
74R1.NT.F363 11.215407
75R1.NT.F370 11.17254212
76R1.NT.Y377 14.1854281
77R1.NT.Q393 6.3475415
78R1.NT.M397 6.246516
79R1.NT.I401 5.0775418
80R1.NT.N402 5.585407
81R1.NT.Y405 4.91333617
82R1.NT.C419 4.6485343
83R1.NT.F446 7.556508
84R1.NT.V449 6.745413
85R1.NT.S450 5.17404
86R1.NT.F456 4.61509
87R1.NT.D461 7.0125438
88R1.NT.R465 7.7425405
89R1.NT.Y466 6.77549
90R1.NT.I468 4.06478
91R1.NT.N470 4.905478
92R1.NT.Y481 6.6494
93R1.NT.V484 3.39578
94R1.NT.W487 6.875646
95R1.NT.M494 4.32667676
96R1.NT.W500 8.875407
97R1.NT.I520 5.50254356
98R1.NT.K521 6.274198
99R1.NT.T535 3.8654194
100R1.NT.E541 9.94754197
101R1.NT.Y542 5.444117
102R1.NT.C552 5.984119
103R1.NT.Q571 12.4025406
104R1.1x61 7.734168
105R1.I1x47 4.75754169
106R1.I1x49 5.40754166
107R1.2x36 5.1625408
108R1.2x46 3.3485168
109R1.2x50 5.14667608
110R1.3x26 6.694233
111R1.3x28 5.5445397
112R1.3x33 9.1775408
113R1.3x39 4.6254387
114R1.3x42 3.825405
115R1.3x44 5.185247
116R1.4x43 7.0856409
117R1.4x51 5.49754236
118R1.E2.P717 7.0745238
119R1.E2.V729 3.9225407
120R1.E2.L731 6.4125376
121R1.5x46 7.5425408
122R1.I3.V764 2.9475408
123R1.6x50 4.3665248
124R1.6x57 7.472508
125R1.6x58 5.1225406
126R1.7x31 2.8825408
127R1.7x34 5.3925407
128R1.7x35 2.9725407
129R1.7x45 3.6685168
130R1.7x48 7.846168
131R1.7x51 7.184169
132R1.7x55 4.5745168
133R2.NT.R26 4.11254143
134R2.NT.F41 6.182528
135R2.NT.H44 7.2575427
136R2.NT.R55 5.784142
137R2.NT.C57 4.46408
138R2.NT.Y64 7.744504
139R2.NT.I66 4.6425406
140R2.NT.R68 8.55524
141R2.NT.V69 5.31405
142R2.NT.E70 7.168527
143R2.NT.M72 5.00667628
144R2.NT.H74 7.9825427
145R2.NT.T75 5.8075429
146R2.NT.R78 14.13428
147R2.NT.L85 5.82754436
148R2.NT.L86 4.145439
149R2.NT.I95 4.52167627
150R2.NT.R96 10.788504
151R2.NT.W100 7.0175403
152R2.NT.H101 3.87754414
153R2.NT.V104 5.244143
154R2.NT.E107 7.16254145
155R2.NT.I110 5.17254145
156R2.NT.R114 7.7525407
157R2.NT.L117 6.70754134
158R2.NT.P149 4.97167656
159R2.NT.V158 5.215455
160R2.NT.L162 4.296557
161R2.NT.Q169 5.89286758
162R2.NT.Y172 8.552527
163R2.NT.F185 6.584506
164R2.NT.Y187 9.0075407
165R2.NT.F188 8.07572758
166R2.NT.M189 4.55456
167R2.NT.R190 7.7775459
168R2.NT.P193 5.2468
169R2.NT.S194 3.755458
170R2.NT.Q198 8.0575469
171R2.NT.Y209 9.18488
172R2.NT.W211 8.048589
173R2.NT.Y213 4.24429709
174R2.NT.Y223 14.3825467
175R2.NT.Y246 8.51505
176R2.NT.F257 4.794464
177R2.NT.L261 5.8825175
178R2.NT.L264 7.654177
179R2.NT.T265 6.5485174
180R2.NT.L268 7.594174
181R2.NT.R272 10.8925405
182R2.NT.V273 8.2325488
183R2.NT.V274 4.594176
184R2.NT.F277 6.95767
185R2.NT.C278 4.014104
186R2.NT.V283 6.2554105
187R2.NT.F299 7.6925177
188R2.NT.W307 6.7785107
189R2.NT.V313 3.866676104
190R2.NT.Y317 7.6345473
191R2.NT.W336 12.555425
192R2.NT.F337 10.9025427
193R2.NT.Y341 8.262526
194R2.NT.R345 4.8954224
195R2.NT.P346 10.1954226
196R2.NT.E347 4.85754224
197R2.NT.N349 9.18424
198R2.NT.R351 8.5175424
199R2.NT.N352 7.57833627
200R2.NT.P353 4.9025423
201R2.NT.W354 8.372525
202R2.NT.F355 7.385424
203R2.NT.F358 5.8975406
204R2.NT.W359 10.894227
205R2.NT.H361 5.434423
206R2.NT.F363 11.215407
207R2.NT.F370 11.17254222
208R2.NT.Y377 14.1854421
209R2.NT.Q393 6.3475425
210R2.NT.M397 6.246526
211R2.NT.I401 5.0775428
212R2.NT.N402 5.585407
213R2.NT.Y405 4.91333627
214R2.NT.C419 4.6485483
215R2.NT.F446 7.556508
216R2.NT.V449 6.745423
217R2.NT.S450 5.17404
218R2.NT.F456 4.61509
219R2.NT.D461 7.0125458
220R2.NT.R465 7.7425405
221R2.NT.Y466 6.77569
222R2.NT.I468 4.06488
223R2.NT.N470 4.905488
224R2.NT.Y481 6.64104
225R2.NT.V484 3.39588
226R2.NT.W487 6.875666
227R2.NT.M494 4.32667686
228R2.NT.W500 8.875407
229R2.NT.I520 5.50254496
230R2.NT.K521 6.274208
231R2.NT.T535 3.8654204
232R2.NT.E541 9.94754207
233R2.NT.Y542 5.444127
234R2.NT.C552 5.984129
235R2.NT.Q571 12.4025406
236R2.1x61 7.734188
237R2.I1x47 4.75754189
238R2.I1x49 5.40754186
239R2.2x36 5.1625408
240R2.2x46 3.3485188
241R2.2x50 5.14667608
242R2.3x26 6.694253
243R2.3x28 5.5445537
244R2.3x33 9.1775408
245R2.3x39 4.6254527
246R2.3x42 3.825405
247R2.3x44 5.894267
248R2.4x43 7.0856549
249R2.4x51 5.49754256
250R2.E2.P717 7.0745258
251R2.E2.V729 3.9225407
252R2.E2.L731 6.4125516
253R2.5x46 7.5425548
254R2.I3.V764 2.9475408
255R2.6x50 4.3665268
256R2.6x57 7.472508
257R2.6x58 5.1225406
258R2.7x31 2.8825408
259R2.7x34 5.3925407
260R2.7x35 2.9725407
261R2.7x45 3.6685188
262R2.7x48 7.846188
263R2.7x51 7.184189
264R2.7x55 4.5745188
265R1.Lig 9.57286700
266R2.Lig 9.57286700
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R1.NT.V43 R1.NT.W354 26.845615.94NoYes155
2R1.NT.D97 R1.NT.V43 26.86897.3NoNo195
3R1.NT.C99 R1.NT.D97 32.07639.34NoNo079
4R1.NT.C99 R1.NT.V104 37.730710.25NoYes073
5R1.NT.Q108 R1.NT.R96 40.172316.35NoYes054
6R1.NT.I95 R1.NT.W354 20.72934.7YesYes175
7R1.NT.I95 R1.NT.M72 11.54792.92YesYes178
8R1.NT.F112 R1.NT.R96 97.896412.83NoYes064
9R1.NT.F112 R1.NT.L40 97.22694.87NoNo066
10R1.NT.L40 R1.NT.P149 90.32534.93NoYes366
11R1.Lig R1.NT.W100 86.85087.48YesYes003
12R1.Lig R1.NT.Y64 10.20536.84YesYes004
13R1.NT.H44 R1.NT.V60 10.50684.15YesNo075
14R1.NT.E111 R1.NT.R96 68.91749.3NoYes034
15R1.NT.S151 R1.NT.W100 85.73388.65NoYes043
16R1.NT.E111 R2.NT.R114 68.92055.82NoYes037
17R2.NT.Q108 R2.NT.R96 38.108816.35NoYes054
18R2.NT.E111 R2.NT.R96 68.92889.3NoYes034
19R1.NT.R114 R2.NT.E111 68.92625.82YesNo073
20R1.NT.D115 R1.NT.R114 68.92052.38NoYes057
21R1.NT.D115 R1.NT.R96 68.91742.38NoYes054
22R2.NT.D115 R2.NT.R96 68.92882.38NoYes054
23R2.NT.D115 R2.NT.R114 68.92622.38NoYes057
24R1.NT.P149 R1.NT.V154 85.95275.3YesNo064
25R2.NT.F112 R2.NT.L40 99.39914.87NoNo066
26R2.NT.F112 R2.NT.R96 10012.83NoYes064
27R1.Lig R1.NT.Y223 10.067427.37YesYes007
28R1.Lig R1.NT.E279 85.81433.87YesNo004
29R1.NT.E279 R1.NT.T219 85.39115.64NoNo045
30R1.NT.T219 R1.NT.T282 85.28537.85NoNo054
31R1.NT.I248 R1.NT.T282 82.57013.04NoNo064
32R1.NT.I248 R1.NT.L260 81.35274.28NoNo065
33R1.NT.L260 R1.NT.Y246 81.14027.03NoYes055
34R1.NT.L264 R1.NT.Y246 80.04994.69YesYes075
35R1.NT.L264 R1.NT.S215 79.22326.01YesNo1578
36R1.NT.A243 R1.NT.S215 79.18313.42NoNo098
37R1.NT.A243 R1.NT.Y213 79.07014NoYes099
38R1.NT.C511 R1.NT.Y213 77.45524.03NoYes099
39R1.NT.C511 R1.NT.S512 77.27381.72NoNo098
40R1.NT.S512 R1.NT.W532 77.159317.3NoNo088
41R1.NT.C515 R1.NT.V522 75.43191.71NoNo095
42R1.NT.V522 R1.NT.W532 75.547620.84NoNo058
43R1.NT.C515 R1.NT.I520 75.17734.91NoYes3596
44R1.NT.E516 R1.NT.I520 73.56845.47NoYes036
45R1.NT.L562 R1.NT.Q519 73.099115.97NoNo066
46R1.NT.G518 R1.NT.Q519 73.21651.64NoNo096
47R1.NT.E516 R1.NT.G518 73.33391.64NoNo039
48R1.NT.P558 R1.NT.W557 72.746313.51NoNo087
49R1.NT.L562 R1.NT.P558 72.8649.85NoNo068
50R1.NT.I568 R1.NT.W557 72.15663.52NoNo087
51R1.E2.V729 R1.NT.I568 71.92013.07YesNo078
52R1.E2.V729 R1.NT.V570 71.1663.21YesNo074
53R1.E2.L731 R1.NT.V570 70.907113.41YesNo3764
54R1.2x53 R1.7x34 19.515310.14NoYes077
55R1.2x53 R1.7x38 22.94913.2NoNo078
56R1.2x50 R1.7x38 23.52112.54YesNo088
57R1.2x46 R1.2x50 26.95143.63YesYes088
58R1.2x46 R1.7x45 28.07134.28YesYes1688
59R1.7x45 R1.7x48 32.06794.87YesYes1688
60R1.2x39 R1.7x48 20.28784.19NoYes098
61R1.2x39 R1.I1x53 20.573.44NoNo099
62R1.3x50 R1.I1x53 47.41716.12NoNo099
63R1.2x35 R1.3x50 50.75513.06NoNo099
64R1.2x35 R1.3x53 51.58775.27NoNo098
65R1.3x53 R1.4x32 51.8655.84NoNo088
66R1.3x49 R1.4x32 52.14238.5NoNo068
67R1.3x49 R1.4x35 52.41953.04NoNo067
68R1.4x35 R1.4x39 52.69662.85NoNo074
69R1.4x39 R1.5x46 53.25063.52NoYes048
70R1.4x43 R1.5x46 63.97649.02YesYes4098
71R1.4x43 R1.4x47 65.62615.49YesNo096
72R1.4x47 R1.4x51 65.89925.02NoYes066
73R1.3x30 R1.4x51 33.29943.09NoYes2346
74R1.3x26 R1.3x30 33.430612.4YesNo2334
75R1.3x26 R1.E2.I719 68.91534.12YesNo036
76R1.E2.I719 R1.E2.L731 69.03574.28NoYes066
77R1.7x48 R1.7x51 20.32317.44YesYes1689
78R1.7x51 R1.I1x53 26.56944.59YesNo099
79R1.4x51 R1.E2.P717 33.418410.11YesYes2368
80R1.3x26 R1.E2.P717 35.12326.32YesYes2338
81R1.5x46 R1.5x50 10.19037.03YesNo089
82R1.2x56 R1.7x34 10.91766.35NoYes077
83R2.NT.Q108 R2.NT.V104 36.07162.87NoYes1453
84R2.NT.C99 R2.NT.V104 35.821510.25NoYes073
85R2.NT.C99 R2.NT.D97 30.459.34NoNo079
86R2.NT.D97 R2.NT.V43 25.50287.3NoNo295
87R2.NT.V43 R2.NT.W354 25.48815.94NoYes255
88R2.NT.I95 R2.NT.W354 19.80624.7YesYes275
89R2.NT.I95 R2.NT.M72 10.97622.92YesYes278
90R2.NT.L40 R2.NT.P149 92.85484.93NoYes566
91R2.NT.P149 R2.NT.V154 88.86515.3YesNo064
92R2.NT.S151 R2.NT.V154 88.80043.23NoNo044
93R2.NT.S151 R2.NT.W100 88.6728.65NoYes043
94R2.Lig R2.NT.W100 89.92917.48YesYes003
95R2.Lig R2.NT.Y64 10.89996.84YesYes004
96R2.NT.H44 R2.NT.V60 10.04954.15YesNo075
97R2.Lig R2.NT.E279 90.60743.87YesNo004
98R2.NT.E279 R2.NT.T219 90.21855.64NoNo045
99R2.NT.T219 R2.NT.T282 90.12137.85NoNo054
100R2.NT.I248 R2.NT.T282 87.61473.04NoNo064
101R2.NT.I248 R2.NT.L260 86.50594.28NoNo065
102R2.NT.L260 R2.NT.Y246 86.31057.03NoYes055
103R2.NT.L264 R2.NT.Y246 85.28324.69YesYes075
104R2.NT.L264 R2.NT.S215 84.85086.01YesNo1778
105R2.NT.A243 R2.NT.S215 84.82793.42NoNo098
106R2.NT.A243 R2.NT.Y213 84.72354NoYes099
107R2.NT.C511 R2.NT.Y213 83.22584.03NoYes099
108R2.NT.C511 R2.NT.S512 83.06731.72NoNo098
109R2.NT.S512 R2.NT.W532 82.961417.3NoNo088
110R2.NT.V522 R2.NT.W532 81.469720.84NoNo058
111R2.NT.C515 R2.NT.V522 81.36251.71NoNo095
112R2.NT.C515 R2.NT.I520 81.12224.91NoYes4996
113R2.NT.E516 R2.NT.I520 79.63625.47NoYes036
114R2.NT.E516 R2.NT.G518 79.41891.64NoNo039
115R2.NT.G518 R2.NT.Q519 79.31011.64NoNo096
116R2.NT.L562 R2.NT.Q519 79.201215.97NoNo066
117R2.NT.L562 R2.NT.P558 78.98339.85NoNo068
118R2.NT.P558 R2.NT.W557 78.874113.51NoNo087
119R2.NT.I568 R2.NT.W557 78.32733.52NoNo087
120R2.E2.V729 R2.NT.I568 78.1083.07YesNo078
121R2.E2.V729 R2.NT.V570 77.39963.21YesNo074
122R2.E2.L731 R2.NT.V570 77.15513.41YesNo5164
123R2.E2.I719 R2.E2.L731 75.42654.28NoYes066
124R2.3x26 R2.E2.I719 75.31474.12YesNo036
125R2.3x26 R2.3x30 36.677412.4YesNo2534
126R2.3x30 R2.4x51 36.55343.09NoYes2546
127R2.4x47 R2.4x51 72.46295.02NoYes066
128R2.4x43 R2.4x47 72.20275.49YesNo096
129R2.4x43 R2.5x46 70.62879.02YesYes5498
130R2.4x39 R2.5x46 69.33473.52NoYes048
131R2.4x35 R2.4x39 68.81222.85NoNo074
132R2.3x49 R2.4x35 68.55083.04NoNo067
133R2.3x49 R2.4x32 68.28938.5NoNo068
134R2.3x53 R2.4x32 68.02785.84NoNo088
135R2.2x35 R2.3x53 67.76615.27NoNo098
136R2.2x35 R2.3x50 66.98073.06NoNo099
137R2.3x50 R2.I1x53 63.83146.12NoNo099
138R2.2x39 R2.I1x53 28.923.44NoNo099
139R2.2x39 R2.7x48 28.65214.19NoYes098
140R2.7x45 R2.7x48 30.62744.87YesYes1888
141R2.2x46 R2.7x45 26.8184.28YesYes1888
142R2.2x46 R2.2x50 25.80953.63YesYes088
143R2.2x50 R2.7x38 22.5252.54YesNo088
144R2.2x53 R2.7x38 21.97733.2NoNo078
145R2.2x53 R2.7x34 18.689310.14NoYes077
146R2.3x26 R2.E2.P717 38.30156.32YesYes2538
147R2.4x51 R2.E2.P717 36.689610.11YesYes2568
148R2.7x51 R2.I1x53 34.64944.59YesNo099
149R2.7x48 R2.7x51 28.70467.44YesYes1889
150R2.7x471 R2.7x48 24.064416.17NoYes088
151R2.2x42 R2.7x471 23.52114.37NoNo088
152R2.2x42 R2.3x46 23.07273.25NoNo087
153R2.2x41 R2.3x46 22.5253.25NoNo067
154R2.2x41 R2.3x42 21.97734.37NoYes065
155R2.3x42 R2.4x40 19.78565.83YesNo057
156R2.3x38 R2.4x40 19.23754.28NoNo067
157R2.2x48 R2.3x38 18.68932.77NoNo056
158R2.2x48 R2.3x39 18.1416.01NoYes057
159R2.2x56 R2.7x34 10.4566.35NoYes077
160R2.3x39 R2.3x40 15.39825.34YesNo078
161R2.3x40 R2.5x47 14.84946.52NoNo087
162R2.5x47 R2.6x50 14.30064.52NoYes078
163R1.NT.Q108 R1.NT.V104 38.01512.87NoYes1353
164R1.NT.S151 R1.NT.V154 85.87933.23NoNo044
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
R2.NT.S42R2.NT.W1008.650NoYes6321
R2.NT.Q46R2.NT.W1003.2941NoYes3321
R2.NT.R61R2.NT.Y6412.350NoYes5421
R2.NT.Q63R2.NT.Y646.760NoYes2421
R2.NT.R68R2.NT.Y6411.322YesYes4421
R2.LigR2.NT.Y646.840YesYes0401
R2.NT.S151R2.NT.W1008.650NoYes4321
R2.LigR2.NT.W1007.480YesYes0301
R2.NT.S152R2.NT.S1764.890NoNo9712
R2.LigR2.NT.S1528.760YesNo0901
R2.NT.T175R2.NT.V1923.170NoNo8712
R2.NT.D195R2.NT.T17510.126NoNo8821
R2.LigR2.NT.T1759.680YesNo0801
R2.NT.N222R2.NT.S1762.980NoNo6712
R2.NT.D195R2.NT.Y22310.346NoYes8721
R2.NT.D195R2.NT.F2775.976NoYes8722
R2.NT.E279R2.NT.T2195.640NoNo4512
R2.LigR2.NT.N2223.010YesNo0601
R2.NT.G224R2.NT.Y2234.356NoYes8721
R2.NT.F277R2.NT.Y22315.476YesYes7721
R2.LigR2.NT.Y22327.370YesYes0701
R2.NT.F277R2.NT.G2243.016YesNo7822
R2.NT.E279R2.NT.S2507.190NoNo4312
R2.LigR2.NT.E2793.870YesNo0401
R2.NT.G65R2.NT.Y641.450NoYes5421

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
100.00Single6D35Cholesterol6D35-SMO-Cholesterol
100.00Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
100.00Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
100.00Single6UO8SKF975416UO8-GABAB1, GABAB2-SKF97541-GS39783
100.00Single6UO9SKF975416UO9-GABAB1, GABAB2-SKF97541
100.00Single6W2XPubChem 53110426W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
100.00Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
100.00Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
100.00Single7C7QBaclofen7C7Q-GABAB1, GABAB2-Baclofen-PubChem 7023848
100.00Single7C7SCGP546267C7S-GABAB1, GABAB2-CGP54626
100.00Single7CUMCGP546267CUM-GABAB1, GABAB2-CGP54626-Phospholipid
100.00Single7DD5Ca37DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00Single7DGEQuisqualate7DGE-mGlu1; mGlu1-Quisqualate
100.00Single7DTTCa7DTT-CaS-Ca-Ca
100.00Single7DTTCa7DTT-CaS-Ca-Ca
100.00Single7DTUTryptophan7DTU-CaS-Tryptophan
100.00Single7DTUTryptophan7DTU-CaS-Tryptophan
100.00Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
100.00Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
100.00Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
100.00Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
100.00Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
100.00Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
100.00Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
100.00Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
100.00Single7EB2Baclofen7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
100.00Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
100.00Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
100.00Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
100.00Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
100.00Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
100.00Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
100.00Single7FIHhCG7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
100.00Single7FIIhCG7FII-LH-hCG-6fuf
100.00Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
100.00Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
100.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
100.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
100.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
100.00Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
100.00Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
100.00Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
100.00Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
100.00Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
100.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7T9NM22 Fab7T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
100.00Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
100.00Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
100.00Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
100.00Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
100.00Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
100.00Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
100.00Single7XW6M22 Fab7XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
100.00Single7XW7K1-707XW7-TSH-K1-70
100.00Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
100.00Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
100.00Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
100.00Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
100.00Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
100.00Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
100.00Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
100.00Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
100.00Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
100.00Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
100.00Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
100.00Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
100.00Single8JD0Glutamate8JD0-mGlu2; mGlu3-Glutamate-J9R
100.00Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
100.00Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
100.00Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
100.00Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
100.00Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
100.00Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
100.00Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
100.00Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
100.00Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
100.00Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
100.00Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
100.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
100.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
100.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
100.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
100.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
100.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
100.00Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
100.00Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
100.00Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
100.00Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
100.00Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
100.00Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
100.00Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
100.00Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
100.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
100.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
100.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
100.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
100.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
100.00Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
100.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
100.00Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
100.00Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
100.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
100.00Consensusclass-c_offOrthosteric Ligandgabab_off mglu_off
100.00Consensusclass-c_offOrthosteric Ligandgabab_off mglu_off
100.00Consensusclass-c_onOrthosteric Ligandgabab_on mglu_on
100.00Consensusclass-c_onOrthosteric Ligandgabab_on mglu_on
100.00Consensusfsh_on_alloOrthosteric Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
100.00Consensusgabab_offOrthosteric Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
100.00Consensusgabab_onOrthosteric Ligand7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
100.00Consensusgi_class-cOrthosteric Ligandgi_mglu gi_gaba
100.00Consensusgi_class-cOrthosteric Ligandgi_mglu gi_gaba
100.00Consensusgi_gabaOrthosteric Ligand7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
100.00Consensusgi_mgluOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00Consensusgi_mgluOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00Consensusgphr_onOrthosteric Ligandlh_on tsh_on
100.00Consensusgs_gphrOrthosteric Ligand7T9I-TSH-TSH-Gs/&β;1/&γ;2 7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
100.00Consensusgs_proteinOrthosteric Ligandgs_gphr
100.00Consensuslh_onOrthosteric Ligand7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
100.00Consensuslh_on_alloOrthosteric Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
100.00Consensusmglu2_offOrthosteric Ligand7MTQ-mGlu2; mGlu2-LY341495
100.00Consensusmglu2_offOrthosteric Ligand7MTQ-mGlu2; mGlu2-LY341495
100.00Consensusmglu2_onOrthosteric Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
100.00Consensusmglu2_onOrthosteric Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
100.00Consensusmglu3_offOrthosteric Ligand7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
100.00Consensusmglu3_offOrthosteric Ligand7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
100.00Consensusmglu4_onOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00Consensusmglu4_onOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00Consensusmglu5_offOrthosteric Ligand7FD9-mGlu5; mGlu5-LY341495
100.00Consensusmglu_offOrthosteric Ligandmglu2_off mglu3_off mglu5_off
100.00Consensusmglu_offOrthosteric Ligandmglu2_off mglu3_off mglu5_off
100.00Consensusmglu_onOrthosteric Ligandmglu2_on mglu4_on
100.00Consensusmglu_onOrthosteric Ligandmglu2_on mglu4_on
100.00Consensussmo_off_alloOther Ligand6D32-SMO-Cyclopamine-Cyclopamine
100.00Consensustsh_onOrthosteric Ligand7T9I-TSH-TSH-Gs/&β;1/&γ;2
100.00Consensustsh_on_alloOrthosteric Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
50.00Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
50.00Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
33.33Single7KNUCalcitonin gene-related peptide-17KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
33.33Single7T9MCS-17 Antibody7T9M-TSH-CS-17 Antibody
33.33Single8HS2Fab0468HS2-GPR20-Fab046
25.00Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
25.00Single7FIGhCG7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
25.00Single7UTZTR14027UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
25.00Single7XW5TSH7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
25.00Single7ZI0Cholesterol7ZI0-SMO-SAG-Cholesterol
20.00Single5L7DCholesterol5L7D-SMO-Cholesterol
20.00Single7T9ITSH7T9I-TSH-TSH-Gs/&β;1/&γ;2
20.00Single8HSCFab0468HSC-GPR20-Fab046-Gi1/&β;1/&γ;2
20.00Single8I2GGlycoprotein hormones alpha chain8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
16.67Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
16.67Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/&β;1/&γ;2
14.29Single4XNWMRS25004XNW-P2Y1-MRS2500
14.29Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
14.29Single6LI0GTPL98046LI0-GPR52-GTPL9804
14.29Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
14.29Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
14.29Consensussmo_off_alloOrthosteric Ligand6D32-SMO-Cyclopamine-Cyclopamine
12.50Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
12.50Single4O9RCyclopamine4O9R-SMO-Cyclopamine
12.50Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
12.50Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
12.50Consensusgo_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
12.50Consensusgo_proteinOrthosteric Ligandgo_chemokine
12.50Consensussmo_on_alloOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
11.11Single4BWBNeurotensin4BWB-NTS1-Neurotensin
11.11Single4QINSAG1.54QIN-SMO-SAG1.5
11.11Single5U09Taranabant5U09-CB1-Taranabant
11.11Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
11.11Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
11.11Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
11.11Single6WWZCCL206WWZ-CCR6-CCL20-Go/&β;1/&γ;2
11.11Single7BR3Elagolix7BR3-GnRH1-Elagolix
11.11Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
11.11Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
11.11Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
11.11Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
11.11Single8FN0Neurotensin/neuromedin N8FN0-NTS1-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
11.11Single8HMPPubChem 699214798HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
11.11Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
11.11Consensusclass-f_offOrthosteric Ligandsmo_off
11.11Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
11.11Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
11.11Consensusp2y_offOrthosteric Ligandp2y1_off p2y12_off
10.00Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
10.00Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
10.00Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
10.00Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
10.00Single7VV6C48/807VV6-MRGPRX2-C48/80
10.00Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
10.00Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
10.00Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.00Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
10.00Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
10.00Consensuscxcr_onOrthosteric Ligandcxcr1_on cxcr2_on
10.00Consensusgi_class-fOrthosteric Ligandgi_frizzled
10.00Consensusgi_frizzledOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
10.00Consensusgnrh_offOrthosteric Ligandgnrh1_off
10.00Consensuslh_on_alloOther Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
10.00Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
10.00Consensuss1p_offOrthosteric Ligands1p1_off
9.09Single4QIMPubChem 249053754QIM-SMO-PubChem 24905375
9.09Single5T04Neurotensin5T04-NTS1-Neurotensin
9.09Single5TGZAM65385TGZ-CB1-AM6538
9.09Single6D27CAY104716D27-DP2-CAY10471
9.09Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
9.09Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
9.09Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
9.09Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
9.09Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
9.09Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
9.09Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
9.09Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
9.09Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
9.09Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
9.09Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
9.09Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
9.09Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
9.09Consensusfsh_on_alloOther Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
9.09Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
9.09Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
9.09Consensussmo_offOrthosteric Ligand5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
8.33Single4JKVTaladegib (LY2940680)4JKV-SMO-Taladegib (LY2940680)
8.33Single5C1MBU725C1M-μ-BU72
8.33Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
8.33Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
8.33Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
8.33Single7C4SS1P7C4S-S1P3-S1P
8.33Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
8.33Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
8.33Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
8.33Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
8.33Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
8.33Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
8.33Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
8.33Single7YXAONO-54306087YXA-S1P5-ONO-5430608
8.33Single8FN1Neurotensin/neuromedin N8FN1-NTS1-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
8.33Single8JPCNeurotensin 8-138JPC-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
7.69Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
7.69Single4BV0Neurotensin4BV0-NTS1-Neurotensin
7.69Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
7.69Single5V56TC1145V56-SMO-TC114
7.69Single5V57TC1145V57-SMO-TC114
7.69Single6OS1TRV0266OS1-AT1-TRV026
7.69Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
7.69Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
7.69Single7F1TMIP-1a7F1T-CCR5-MIP-1a
7.69Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
7.69Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1
7.69Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/&β;1/&γ;1
7.69Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
7.69Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
7.69Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
7.69Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
7.69Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
7.69Single8E0GBU728E0G-μ-BU72
7.69Single8FMZNeurotensin/neuromedin N8FMZ-NTS1-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.69Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
7.69Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
7.69Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
7.69Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
7.69Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
7.69Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
7.69Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
7.69Consensuslpa_offOrthosteric Ligandlpa1_off
7.69Consensuslpa_onOrthosteric Ligandlpa1_on
7.69Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
7.69Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
7.14Single4GRVNeurotensin 8-134GRV-NTS1-Neurotensin 8-13
7.14Single4XEENeurotensin4XEE-NTS1-Neurotensin
7.14Single4XESNeurotensin4XES-NTS1-Neurotensin
7.14Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
7.14Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
7.14Single6OS2TRV0266OS2-AT1-TRV026
7.14Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/&β;1/&γ;2
7.14Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
7.14Single6YVRNTS8-136YVR-NTS1-NTS8-13
7.14Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
7.14Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
7.14Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/&β;1/γ1
7.14Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
7.14Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
7.14Single8IBUErythromycin A8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.14Single8JPBNeurotensin 8-138JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
7.14Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.14Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
7.14Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
7.14Consensuschemokine_offOrthosteric Ligandcxcr_off
7.14Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II
7.14Consensuscxcr_offOrthosteric Ligandcxcr4_off
7.14Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
7.14Consensusdp_offOrthosteric Liganddp2_off
7.14Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
7.14Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
7.14Consensusnts1_onOrthosteric Ligand6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
7.14Consensusnts_onOrthosteric Ligandnts1_on
7.14Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
7.14Consensustsh_on_alloOther Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
6.67Single4BUONeurotensin4BUO-NTS1-Neurotensin
6.67Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
6.67Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
6.67Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/&β;1/&γ;2
6.67Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
6.67Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
6.67Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
6.67Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
6.67Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.67Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
6.67Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
6.67Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
6.67Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
6.67Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
6.67Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
6.67Consensusgi_neurotensinOrthosteric Ligand7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
6.67Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
6.25Single6KNMJN241-96KNM-Apelin-JN241-9
6.25Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
6.25Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
6.25Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
6.25Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
6.25Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
6.25Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
6.25Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.25Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
6.25Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
6.25Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
6.25Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
6.25Consensuslpl_offOrthosteric Ligands1p_off lpa_off
6.25Consensuslpl_onOrthosteric Ligands1p_on lpa_on
6.25Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
6.25Consensusmotilin_onOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.25Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.25Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
5.88Single4XT1Fractalkine4XT1-US28-Fractalkine
5.88Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
5.88Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
5.88Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
5.88Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/&β;1/&γ;1
5.88Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
5.88Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
5.88Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
5.88Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
5.88Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
5.88Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
5.88Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
5.88Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
5.88Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
5.88Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
5.88Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
5.88Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
5.56Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
5.56Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
5.56Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
5.56Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
5.56Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
5.56Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
5.56Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
5.56Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
5.56Single7SK5CXCL127SK5-ACKR3-CXCL12
5.56Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
5.56Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
5.56Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.56Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
5.56Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
5.56Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
5.26Single3OE0CVX153OE0-CXCR4-CVX15
5.26Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
5.26Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
5.26Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
5.26Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
5.26Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
5.26Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
5.26Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
5.26Consensusangiotensin_onOrthosteric Ligandat1_on
5.26Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
5.26Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
5.26Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
5.26Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
5.26Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
5.26Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.26Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.26Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
5.26Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
5.26Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
5.00Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
5.00Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
5.00Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
5.00Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
5.00Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
5.00Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
5.00Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
5.00Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
5.00Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
5.00Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
5.00Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.00Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
5.00Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.00Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
5.00Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
5.00Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
5.00Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
5.00Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
5.00Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
5.00Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
5.00Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
5.00Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
5.00Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
5.00Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
5.00Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
4.76Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
4.76Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
4.76Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
4.76Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
4.76Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
4.76Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
4.76Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
4.76Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
4.76Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
4.76Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
4.76Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
4.76Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
4.76Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
4.76Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
4.76Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
4.76Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
4.76Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
4.76Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
4.76Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
4.55Single4XT3Fractalkine4XT3-US28-Fractalkine
4.55Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
4.55Single6FJ3PTH6FJ3-PTH1-PTH
4.55Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
4.55Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
4.55Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
4.55Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
4.55Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
4.55Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
4.55Single7SK3CXCL127SK3-ACKR3-CXCL12
4.55Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
4.55Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
4.55Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
4.55Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
4.55Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
4.55Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
4.55Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
4.55Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
4.55Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
4.55Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
4.55Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
4.55Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
4.55Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
4.55Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
4.35Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
4.35Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
4.35Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
4.35Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
4.35Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
4.35Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
4.35Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
4.35Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
4.35Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
4.35Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
4.35Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
4.35Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
4.35Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
4.35Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
4.35Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
4.35Consensusgo_class-b1Orthosteric Ligandgo_crf
4.35Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
4.35Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
4.17Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
4.17Single6LMLGlucagon6LML-Glucagon-Glucagon
4.17Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
4.17Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
4.17Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
4.17Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
4.17Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
4.17Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
4.17Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
4.17Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
4.17Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
4.17Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
4.17Single8IY6Endothelin-18IY6-ETB-Endothelin-1
4.17Consensuscalcitonin_onOrthosteric Ligandct_on ctlike_on
4.17Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
4.17Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
4.17Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
4.17Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
4.17Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
4.17Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
4.17Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
4.17Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
4.17Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
4.00Single5GLHEndothelin-15GLH-ETB-Endothelin-1
4.00Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
4.00Single6IGKEndothelin-36IGK-ETB-Endothelin-3
4.00Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
4.00Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
4.00Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
4.00Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
4.00Single7TYIAmylin7TYI-CT-Amylin-Gs/&β;1/&γ;2
4.00Single7TYLAmylin7TYL-CT-Amylin-Gs/&β;1/&γ;2
4.00Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
4.00Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/&β;1/&γ;2; RAMP2
4.00Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
4.00Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
4.00Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
3.85Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
3.85Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
3.85Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
3.85Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
3.85Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
3.85Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
3.85Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
3.85Consensusglp_onOrthosteric Ligandglp1_on glp2_on
3.85Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
3.70Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
3.70Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
3.70Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
3.70Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
3.70Single8F0KPramlintide analogue san3858F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
3.70Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
3.70Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
3.70Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
3.70Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
3.70Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
3.57Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
3.57Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
3.57Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
3.57Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
3.57Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
3.57Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
3.57Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
3.57Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
3.57Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
3.57Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
3.57Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
3.57Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
3.57Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
3.45Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
3.45Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
3.45Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
3.45Consensuspth_onOrthosteric Ligandpth1_on pth2_on
3.33Single8F2APramlintide analogue san3858F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
3.33Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
3.23Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
3.23Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
3.23Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
3.12Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
3.12Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
3.12Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
3.03Single8F2BPramlintide analogue san458F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
3.03Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
3.03Consensusgs_ctOrthosteric Ligand7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.94Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
2.94Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
2.86Single8F0JPramlintide analogue san458F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2

2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
R1.NT.S42R1.NT.W1008.650NoYes6321
R1.NT.Q46R1.NT.W1003.2927NoYes3321
R1.NT.R61R1.NT.Y6412.350NoYes5421
R1.NT.Q63R1.NT.Y646.760NoYes2421
R1.NT.R68R1.NT.Y6411.321YesYes4421
R1.LigR1.NT.Y646.840YesYes0401
R1.NT.S151R1.NT.W1008.650NoYes4321
R1.LigR1.NT.W1007.480YesYes0301
R1.NT.S152R1.NT.S1764.890NoNo9712
R1.LigR1.NT.S1528.760YesNo0901
R1.NT.T175R1.NT.V1923.170NoNo8712
R1.NT.D195R1.NT.T17510.124NoNo8821
R1.LigR1.NT.T1759.680YesNo0801
R1.NT.N222R1.NT.S1762.980NoNo6712
R1.NT.D195R1.NT.Y22310.344NoYes8721
R1.NT.D195R1.NT.F2775.974NoYes8722
R1.NT.E279R1.NT.T2195.640NoNo4512
R1.LigR1.NT.N2223.010YesNo0601
R1.NT.G224R1.NT.Y2234.354NoYes8721
R1.NT.F277R1.NT.Y22315.474YesYes7721
R1.LigR1.NT.Y22327.370YesYes0701
R1.NT.F277R1.NT.G2243.014YesNo7822
R1.NT.E279R1.NT.S2507.190NoNo4312
R1.LigR1.NT.E2793.870YesNo0401
R1.NT.G65R1.NT.Y641.450NoYes5421

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
100.00Single6D35Cholesterol6D35-SMO-Cholesterol
100.00Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
100.00Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
100.00Single6UO8SKF975416UO8-GABAB1, GABAB2-SKF97541-GS39783
100.00Single6UO9SKF975416UO9-GABAB1, GABAB2-SKF97541
100.00Single6W2XPubChem 53110426W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
100.00Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
100.00Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
100.00Single7C7QBaclofen7C7Q-GABAB1, GABAB2-Baclofen-PubChem 7023848
100.00Single7C7SCGP546267C7S-GABAB1, GABAB2-CGP54626
100.00Single7CUMCGP546267CUM-GABAB1, GABAB2-CGP54626-Phospholipid
100.00Single7DD5Ca37DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00Single7DGEQuisqualate7DGE-mGlu1; mGlu1-Quisqualate
100.00Single7DTTCa7DTT-CaS-Ca-Ca
100.00Single7DTTCa7DTT-CaS-Ca-Ca
100.00Single7DTUTryptophan7DTU-CaS-Tryptophan
100.00Single7DTUTryptophan7DTU-CaS-Tryptophan
100.00Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
100.00Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
100.00Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
100.00Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
100.00Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
100.00Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
100.00Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
100.00Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
100.00Single7EB2Baclofen7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
100.00Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
100.00Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
100.00Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
100.00Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
100.00Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
100.00Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
100.00Single7FIHhCG7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
100.00Single7FIIhCG7FII-LH-hCG-6fuf
100.00Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
100.00Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
100.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
100.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
100.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
100.00Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
100.00Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
100.00Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
100.00Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
100.00Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
100.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7T9NM22 Fab7T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
100.00Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
100.00Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
100.00Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
100.00Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
100.00Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
100.00Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
100.00Single7XW6M22 Fab7XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
100.00Single7XW7K1-707XW7-TSH-K1-70
100.00Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
100.00Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
100.00Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
100.00Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
100.00Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
100.00Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
100.00Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
100.00Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
100.00Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
100.00Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
100.00Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
100.00Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
100.00Single8JD0Glutamate8JD0-mGlu2; mGlu3-Glutamate-J9R
100.00Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
100.00Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
100.00Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
100.00Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
100.00Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
100.00Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
100.00Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
100.00Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
100.00Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
100.00Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
100.00Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
100.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
100.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
100.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
100.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
100.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
100.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
100.00Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
100.00Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
100.00Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
100.00Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
100.00Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
100.00Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
100.00Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
100.00Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
100.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
100.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
100.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
100.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
100.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
100.00Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
100.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
100.00Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
100.00Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
100.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
100.00Consensusclass-c_offOrthosteric Ligandgabab_off mglu_off
100.00Consensusclass-c_offOrthosteric Ligandgabab_off mglu_off
100.00Consensusclass-c_onOrthosteric Ligandgabab_on mglu_on
100.00Consensusclass-c_onOrthosteric Ligandgabab_on mglu_on
100.00Consensusfsh_on_alloOrthosteric Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
100.00Consensusgabab_offOrthosteric Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
100.00Consensusgabab_onOrthosteric Ligand7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
100.00Consensusgi_class-cOrthosteric Ligandgi_mglu gi_gaba
100.00Consensusgi_class-cOrthosteric Ligandgi_mglu gi_gaba
100.00Consensusgi_gabaOrthosteric Ligand7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
100.00Consensusgi_mgluOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00Consensusgi_mgluOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00Consensusgphr_onOrthosteric Ligandlh_on tsh_on
100.00Consensusgs_gphrOrthosteric Ligand7T9I-TSH-TSH-Gs/&β;1/&γ;2 7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
100.00Consensusgs_proteinOrthosteric Ligandgs_gphr
100.00Consensuslh_onOrthosteric Ligand7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
100.00Consensuslh_on_alloOrthosteric Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
100.00Consensusmglu2_offOrthosteric Ligand7MTQ-mGlu2; mGlu2-LY341495
100.00Consensusmglu2_offOrthosteric Ligand7MTQ-mGlu2; mGlu2-LY341495
100.00Consensusmglu2_onOrthosteric Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
100.00Consensusmglu2_onOrthosteric Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
100.00Consensusmglu3_offOrthosteric Ligand7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
100.00Consensusmglu3_offOrthosteric Ligand7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
100.00Consensusmglu4_onOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00Consensusmglu4_onOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00Consensusmglu5_offOrthosteric Ligand7FD9-mGlu5; mGlu5-LY341495
100.00Consensusmglu_offOrthosteric Ligandmglu2_off mglu3_off mglu5_off
100.00Consensusmglu_offOrthosteric Ligandmglu2_off mglu3_off mglu5_off
100.00Consensusmglu_onOrthosteric Ligandmglu2_on mglu4_on
100.00Consensusmglu_onOrthosteric Ligandmglu2_on mglu4_on
100.00Consensussmo_off_alloOther Ligand6D32-SMO-Cyclopamine-Cyclopamine
100.00Consensustsh_onOrthosteric Ligand7T9I-TSH-TSH-Gs/&β;1/&γ;2
100.00Consensustsh_on_alloOrthosteric Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
50.00Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
50.00Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
33.33Single7KNUCalcitonin gene-related peptide-17KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
33.33Single7T9MCS-17 Antibody7T9M-TSH-CS-17 Antibody
33.33Single8HS2Fab0468HS2-GPR20-Fab046
25.00Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
25.00Single7FIGhCG7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
25.00Single7UTZTR14027UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
25.00Single7XW5TSH7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
25.00Single7ZI0Cholesterol7ZI0-SMO-SAG-Cholesterol
20.00Single5L7DCholesterol5L7D-SMO-Cholesterol
20.00Single7T9ITSH7T9I-TSH-TSH-Gs/&β;1/&γ;2
20.00Single8HSCFab0468HSC-GPR20-Fab046-Gi1/&β;1/&γ;2
20.00Single8I2GGlycoprotein hormones alpha chain8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
16.67Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
16.67Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/&β;1/&γ;2
14.29Single4XNWMRS25004XNW-P2Y1-MRS2500
14.29Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
14.29Single6LI0GTPL98046LI0-GPR52-GTPL9804
14.29Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
14.29Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
14.29Consensussmo_off_alloOrthosteric Ligand6D32-SMO-Cyclopamine-Cyclopamine
12.50Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
12.50Single4O9RCyclopamine4O9R-SMO-Cyclopamine
12.50Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
12.50Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
12.50Consensusgo_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
12.50Consensusgo_proteinOrthosteric Ligandgo_chemokine
12.50Consensussmo_on_alloOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
11.11Single4BWBNeurotensin4BWB-NTS1-Neurotensin
11.11Single4QINSAG1.54QIN-SMO-SAG1.5
11.11Single5U09Taranabant5U09-CB1-Taranabant
11.11Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
11.11Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
11.11Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
11.11Single6WWZCCL206WWZ-CCR6-CCL20-Go/&β;1/&γ;2
11.11Single7BR3Elagolix7BR3-GnRH1-Elagolix
11.11Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
11.11Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
11.11Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
11.11Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
11.11Single8FN0Neurotensin/neuromedin N8FN0-NTS1-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
11.11Single8HMPPubChem 699214798HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
11.11Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
11.11Consensusclass-f_offOrthosteric Ligandsmo_off
11.11Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
11.11Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
11.11Consensusp2y_offOrthosteric Ligandp2y1_off p2y12_off
10.00Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
10.00Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
10.00Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
10.00Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
10.00Single7VV6C48/807VV6-MRGPRX2-C48/80
10.00Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
10.00Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
10.00Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.00Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
10.00Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
10.00Consensuscxcr_onOrthosteric Ligandcxcr1_on cxcr2_on
10.00Consensusgi_class-fOrthosteric Ligandgi_frizzled
10.00Consensusgi_frizzledOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
10.00Consensusgnrh_offOrthosteric Ligandgnrh1_off
10.00Consensuslh_on_alloOther Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
10.00Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
10.00Consensuss1p_offOrthosteric Ligands1p1_off
9.09Single4QIMPubChem 249053754QIM-SMO-PubChem 24905375
9.09Single5T04Neurotensin5T04-NTS1-Neurotensin
9.09Single5TGZAM65385TGZ-CB1-AM6538
9.09Single6D27CAY104716D27-DP2-CAY10471
9.09Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
9.09Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
9.09Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
9.09Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
9.09Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
9.09Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
9.09Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
9.09Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
9.09Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
9.09Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
9.09Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
9.09Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
9.09Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
9.09Consensusfsh_on_alloOther Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
9.09Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
9.09Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
9.09Consensussmo_offOrthosteric Ligand5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
8.33Single4JKVTaladegib (LY2940680)4JKV-SMO-Taladegib (LY2940680)
8.33Single5C1MBU725C1M-μ-BU72
8.33Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
8.33Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
8.33Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
8.33Single7C4SS1P7C4S-S1P3-S1P
8.33Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
8.33Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
8.33Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
8.33Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
8.33Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
8.33Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
8.33Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
8.33Single7YXAONO-54306087YXA-S1P5-ONO-5430608
8.33Single8FN1Neurotensin/neuromedin N8FN1-NTS1-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
8.33Single8JPCNeurotensin 8-138JPC-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
7.69Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
7.69Single4BV0Neurotensin4BV0-NTS1-Neurotensin
7.69Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
7.69Single5V56TC1145V56-SMO-TC114
7.69Single5V57TC1145V57-SMO-TC114
7.69Single6OS1TRV0266OS1-AT1-TRV026
7.69Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
7.69Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
7.69Single7F1TMIP-1a7F1T-CCR5-MIP-1a
7.69Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
7.69Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1
7.69Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/&β;1/&γ;1
7.69Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
7.69Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
7.69Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
7.69Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
7.69Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
7.69Single8E0GBU728E0G-μ-BU72
7.69Single8FMZNeurotensin/neuromedin N8FMZ-NTS1-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.69Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
7.69Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
7.69Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
7.69Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
7.69Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
7.69Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
7.69Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
7.69Consensuslpa_offOrthosteric Ligandlpa1_off
7.69Consensuslpa_onOrthosteric Ligandlpa1_on
7.69Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
7.69Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
7.14Single4GRVNeurotensin 8-134GRV-NTS1-Neurotensin 8-13
7.14Single4XEENeurotensin4XEE-NTS1-Neurotensin
7.14Single4XESNeurotensin4XES-NTS1-Neurotensin
7.14Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
7.14Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
7.14Single6OS2TRV0266OS2-AT1-TRV026
7.14Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/&β;1/&γ;2
7.14Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
7.14Single6YVRNTS8-136YVR-NTS1-NTS8-13
7.14Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
7.14Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
7.14Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/&β;1/γ1
7.14Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
7.14Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
7.14Single8IBUErythromycin A8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.14Single8JPBNeurotensin 8-138JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
7.14Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.14Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
7.14Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
7.14Consensuschemokine_offOrthosteric Ligandcxcr_off
7.14Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II
7.14Consensuscxcr_offOrthosteric Ligandcxcr4_off
7.14Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
7.14Consensusdp_offOrthosteric Liganddp2_off
7.14Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
7.14Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
7.14Consensusnts1_onOrthosteric Ligand6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
7.14Consensusnts_onOrthosteric Ligandnts1_on
7.14Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
7.14Consensustsh_on_alloOther Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
6.67Single4BUONeurotensin4BUO-NTS1-Neurotensin
6.67Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
6.67Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
6.67Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/&β;1/&γ;2
6.67Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
6.67Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
6.67Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
6.67Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
6.67Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.67Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
6.67Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
6.67Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
6.67Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
6.67Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
6.67Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
6.67Consensusgi_neurotensinOrthosteric Ligand7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
6.67Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
6.25Single6KNMJN241-96KNM-Apelin-JN241-9
6.25Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
6.25Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
6.25Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
6.25Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
6.25Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
6.25Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
6.25Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.25Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
6.25Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
6.25Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
6.25Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
6.25Consensuslpl_offOrthosteric Ligands1p_off lpa_off
6.25Consensuslpl_onOrthosteric Ligands1p_on lpa_on
6.25Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
6.25Consensusmotilin_onOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.25Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.25Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
5.88Single4XT1Fractalkine4XT1-US28-Fractalkine
5.88Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
5.88Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
5.88Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
5.88Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/&β;1/&γ;1
5.88Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
5.88Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
5.88Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
5.88Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
5.88Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
5.88Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
5.88Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
5.88Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
5.88Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
5.88Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
5.88Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
5.88Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
5.56Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
5.56Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
5.56Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
5.56Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
5.56Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
5.56Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
5.56Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
5.56Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
5.56Single7SK5CXCL127SK5-ACKR3-CXCL12
5.56Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
5.56Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
5.56Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.56Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
5.56Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
5.56Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
5.26Single3OE0CVX153OE0-CXCR4-CVX15
5.26Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
5.26Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
5.26Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
5.26Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
5.26Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
5.26Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
5.26Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
5.26Consensusangiotensin_onOrthosteric Ligandat1_on
5.26Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
5.26Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
5.26Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
5.26Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
5.26Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
5.26Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.26Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.26Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
5.26Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
5.26Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
5.00Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
5.00Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
5.00Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
5.00Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
5.00Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
5.00Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
5.00Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
5.00Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
5.00Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
5.00Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
5.00Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.00Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
5.00Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.00Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
5.00Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
5.00Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
5.00Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
5.00Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
5.00Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
5.00Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
5.00Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
5.00Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
5.00Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
5.00Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
5.00Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
4.76Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
4.76Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
4.76Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
4.76Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
4.76Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
4.76Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
4.76Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
4.76Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
4.76Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
4.76Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
4.76Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
4.76Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
4.76Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
4.76Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
4.76Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
4.76Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
4.76Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
4.76Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
4.76Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
4.55Single4XT3Fractalkine4XT3-US28-Fractalkine
4.55Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
4.55Single6FJ3PTH6FJ3-PTH1-PTH
4.55Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
4.55Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
4.55Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
4.55Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
4.55Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
4.55Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
4.55Single7SK3CXCL127SK3-ACKR3-CXCL12
4.55Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
4.55Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
4.55Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
4.55Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
4.55Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
4.55Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
4.55Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
4.55Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
4.55Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
4.55Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
4.55Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
4.55Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
4.55Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
4.55Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
4.35Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
4.35Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
4.35Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
4.35Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
4.35Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
4.35Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
4.35Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
4.35Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
4.35Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
4.35Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
4.35Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
4.35Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
4.35Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
4.35Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
4.35Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
4.35Consensusgo_class-b1Orthosteric Ligandgo_crf
4.35Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
4.35Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
4.17Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
4.17Single6LMLGlucagon6LML-Glucagon-Glucagon
4.17Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
4.17Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
4.17Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
4.17Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
4.17Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
4.17Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
4.17Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
4.17Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
4.17Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
4.17Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
4.17Single8IY6Endothelin-18IY6-ETB-Endothelin-1
4.17Consensuscalcitonin_onOrthosteric Ligandct_on ctlike_on
4.17Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
4.17Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
4.17Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
4.17Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
4.17Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
4.17Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
4.17Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
4.17Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
4.17Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
4.00Single5GLHEndothelin-15GLH-ETB-Endothelin-1
4.00Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
4.00Single6IGKEndothelin-36IGK-ETB-Endothelin-3
4.00Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
4.00Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
4.00Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
4.00Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
4.00Single7TYIAmylin7TYI-CT-Amylin-Gs/&β;1/&γ;2
4.00Single7TYLAmylin7TYL-CT-Amylin-Gs/&β;1/&γ;2
4.00Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
4.00Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/&β;1/&γ;2; RAMP2
4.00Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
4.00Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
4.00Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
3.85Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
3.85Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
3.85Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
3.85Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
3.85Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
3.85Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
3.85Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
3.85Consensusglp_onOrthosteric Ligandglp1_on glp2_on
3.85Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
3.70Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
3.70Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
3.70Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
3.70Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
3.70Single8F0KPramlintide analogue san3858F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
3.70Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
3.70Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
3.70Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
3.70Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
3.70Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
3.57Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
3.57Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
3.57Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
3.57Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
3.57Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
3.57Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
3.57Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
3.57Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
3.57Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
3.57Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
3.57Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
3.57Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
3.57Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
3.45Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
3.45Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
3.45Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
3.45Consensuspth_onOrthosteric Ligandpth1_on pth2_on
3.33Single8F2APramlintide analogue san3858F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
3.33Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
3.23Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
3.23Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
3.23Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
3.12Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
3.12Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
3.12Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
3.03Single8F2BPramlintide analogue san458F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
3.03Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
3.03Consensusgs_ctOrthosteric Ligand7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.94Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
2.94Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
2.86Single8F0JPramlintide analogue san458F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2

Consensus Members
Id Members
7FD9 7FD9-mGlu5; mGlu5-LY341495
Net Summary
Imin 2.87
Number of Linked Nodes 1452
Number of Links 1707
Number of Hubs 266
Number of Links mediated by Hubs 966
Number of Communities 54
Number of Nodes involved in Communities 378
Number of Links involved in Communities 506
Path Summary
Number Of Nodes in MetaPath 165
Number Of Links MetaPath 164
Number of Shortest Paths 4557431
Length Of Smallest Path 3
Average Path Length 57.7262
Length of Longest Path 140
Minimum Path Strength 1.15
Average Path Strength 6.34327
Maximum Path Strength 23.68
Minimum Path Correlation 0.7
Average Path Correlation 0.997763
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 3.44828
Average % Of Corr. Nodes 48.7767
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 37.6261
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following consensuses:
IdComponents
mglu_offmglu2_off
mglu3_off
mglu5_off



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