psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	1x35	1x39	4.425	Yes	No	0	5	9
2	1x35	E2.S416	4.8	Yes	No	0	5	2
3	1x37	1x41	6.205	No	No	0	1	4
4	1x39	E2.L417	3.46	No	No	0	9	3
5	1x40	1x44	3.545	No	No	0	6	4
6	1x40	2x68	3.965	No	No	0	6	5
7	1x41	1x44	5.26	No	No	0	4	4
8	1x42	7x38	4.605	No	No	0	8	6
9	1x42	7x39	7.255	No	No	0	8	8
10	1x43	2x64	5.28	No	Yes	0	8	9
11	1x47	2x61	6.3	No	No	0	7	7
12	1x47	2x64	4.19	No	Yes	0	7	9
13	1x47	2x65	7.935	No	No	0	7	7
14	1x49	7x46	4.85	No	No	0	5	8
15	1x50	2x61	8.195	No	No	1	9	7
16	1x50	7x45	7.45	No	No	1	9	9
17	1x51	2x58	9.33	Yes	No	0	6	6
18	1x51	2x65	3.535	Yes	No	0	6	7
19	1x53	7x51	7.21	No	No	0	7	6
20	1x53	7x54	6.98	No	No	0	7	8
21	1x54	2x58	4.26	No	No	0	7	6
22	1x57	7x54	3.38	No	No	0	8	8
23	1x57	7x57	5.84	No	No	0	8	7
24	1x60	1x64	4.15	No	No	0	7	4
25	1x61	1x65	7.2	Yes	No	0	6	7
26	1x61	I1x50	3.61	Yes	Yes	0	6	5
27	1x61	2x51	15.14	Yes	No	0	6	6
28	1x61	7x57	4.645	Yes	No	0	6	7
29	1x64	1x68	5.465	No	Yes	0	4	6
30	1x64	I1x50	8.525	No	Yes	0	4	5
31	1x65	2x48	3.095	No	No	0	7	6
32	1x68	I1x49	5.33	Yes	No	0	6	6
33	1x68	I4.P527	5.765	Yes	No	0	6	6
34	I1x49	I1x50	3.74	No	Yes	0	6	5
35	2x44	I1x49	12.21	No	No	0	7	6
36	2x47	I1x50	6.5	No	Yes	3	6	5
37	7x61	I1x50	5.675	Yes	Yes	3	6	5
38	2x44	2x47	6.29	No	No	0	7	6
39	2x45	4x42	5.175	No	Yes	0	4	6
40	2x47	7x61	12.52	No	Yes	3	6	6
41	2x48	4x43	11.17	No	No	0	6	5
42	2x49	3x50	4.1	No	No	0	8	9
43	2x49	3x53	5.965	No	Yes	0	8	7
44	2x50	3x50	9.235	No	No	0	8	9
45	2x50	7x56	10.055	No	No	0	8	7
46	2x52	3x46	7.13	No	Yes	0	8	9
47	2x53	3x50	5.305	No	No	0	8	9
48	2x56	3x42	3.44	No	Yes	0	7	7
49	2x59	3x39	12.18	No	Yes	0	5	7
50	2x60	3x40	3.46	No	No	0	8	7
51	2x61	7x45	10.215	No	No	1	7	9
52	2x64	2x68	7.87	Yes	No	0	9	5
53	2x64	3x36	5.895	Yes	Yes	0	9	8
54	2x64	Lig	15.025	Yes	Yes	0	9	0
55	2x67	3x32	5.425	No	Yes	0	6	6
56	2x67	3x36	7.855	No	Yes	0	6	8
57	E1.S331	E2.E418	11.5	No	No	0	4	3
58	3x29	3x32	6.965	No	Yes	2	9	6
59	3x29	E2x50	7.28	No	No	2	9	9
60	3x30	4x64	5.65	No	No	0	4	5
61	3x30	E2.Y403	10.615	No	Yes	0	4	9
62	3x32	E2x50	4.18	Yes	No	2	6	9
63	3x34	E2.Y403	6.005	No	Yes	0	5	9
64	3x35	3x39	3.275	No	Yes	0	4	7
65	3x36	E2x51	7.02	Yes	Yes	0	8	8
66	3x37	3x41	10.93	Yes	Yes	1	9	9
67	3x37	4x60	3.425	Yes	Yes	1	9	7
68	3x37	E2.Y403	9.255	Yes	Yes	1	9	9
69	3x37	E2x51	4.235	Yes	Yes	1	9	8
70	3x37	E2x52	13.575	Yes	Yes	1	9	7
71	3x37	5x381	5.48	Yes	No	1	9	7
72	3x38	3x39	4.645	Yes	Yes	0	7	7
73	3x38	3x42	8.735	Yes	Yes	1	7	7
74	3x38	4x53	5.56	Yes	Yes	1	7	9
75	3x38	4x57	3.79	Yes	No	0	7	9
76	3x40	3x44	5.48	No	Yes	0	7	8
77	3x41	4x53	3.285	Yes	Yes	1	9	9
78	3x41	4x56	3.535	Yes	No	1	9	7
79	3x41	5x42	4.69	Yes	Yes	1	9	8
80	3x42	4x50	5.22	Yes	No	1	7	9
81	3x42	4x53	4.71	Yes	Yes	1	7	9
82	3x44	5x42	3.61	Yes	Yes	1	8	8
83	3x44	5x43	7.5	Yes	No	1	8	6
84	3x44	6x53	7.015	Yes	Yes	0	8	9
85	3x44	6x57	5.02	Yes	Yes	1	8	5
86	3x45	4x491	3.64	No	No	0	6	7
87	3x45	4x53	5.25	No	Yes	0	6	9
88	3x45	5x42	7.49	No	Yes	0	6	8
89	3x46	3x49	7.97	Yes	No	0	9	7
90	3x46	4x47	3.09	Yes	No	1	9	5
91	3x46	4x491	4.22	Yes	No	0	9	7
92	3x46	4x50	14.055	Yes	No	1	9	9
93	3x47	6x53	6.98	No	Yes	0	9	9
94	3x49	4x46	3.46	No	No	0	7	7
95	3x52	3x56	6.09	No	Yes	4	5	6
96	3x52	4x42	3.09	No	Yes	4	5	6
97	3x52	5x49	3.22	No	Yes	0	5	5
98	3x53	3x57	9	Yes	No	0	7	6
99	3x53	4x42	7.62	Yes	Yes	0	7	6
100	3x54	6x42	4.845	No	No	0	8	6
101	3x55	3x56	3.52	No	Yes	0	8	6
102	3x55	3x59	10.725	No	No	0	8	7
103	3x55	3x60	3.085	No	No	0	8	6
104	3x56	I2.F375	4.26	Yes	No	0	6	4
105	3x56	4x42	4.69	Yes	Yes	4	6	6
106	3x60	I2.T373	3.235	No	No	0	6	5
107	4x41	4x44	5.785	No	No	0	5	5
108	4x42	4x46	14.065	Yes	No	0	6	7
109	4x43	4x47	5.285	No	No	0	5	5
110	4x47	4x50	5.56	No	No	1	5	9
111	4x52	4x53	3.28	No	Yes	0	3	9
112	4x52	5x42	3.515	No	Yes	0	3	8
113	4x56	5x42	5.39	No	Yes	1	7	8
114	4x57	E2.Y403	4.42	No	Yes	0	9	9
115	4x58	4x59	3.53	No	No	0	4	5
116	4x60	E2.S402	5.6	Yes	Yes	1	7	4
117	4x60	E2.Y403	6.87	Yes	Yes	1	7	9
118	4x60	E2x52	3.24	Yes	Yes	1	7	7
119	4x60	5x381	4.71	Yes	No	1	7	7
120	E2.S402	E2.Y403	3.18	Yes	Yes	1	4	9
121	E2.S402	E2x52	4.62	Yes	Yes	1	4	7
122	5x35	E2.S402	3.42	No	Yes	0	5	4
123	E2.I408	E2.Y406	3.025	No	No	0	6	2
124	E2.Y406	E2x51	6.27	No	Yes	0	2	8
125	E2.E424	E2.Y406	6.17	No	No	0	4	2
126	E2.R409	E2.T407	5.82	No	No	0	3	3
127	E2.D410	E2.S416	8.095	No	No	0	4	2
128	E2.E412	E2.R414	13.375	No	No	0	3	4
129	E2.E418	E2.T415	3.525	No	No	0	3	4
130	E2x51	E2x52	15.535	Yes	Yes	1	8	7
131	5x36	E2x51	5.125	No	Yes	1	6	8
132	5x39	E2x51	3.065	No	Yes	0	8	8
133	E2x51	Lig	4.425	Yes	Yes	1	8	0
134	5x36	E2x52	7.31	No	Yes	1	6	7
135	E2.G425	E2.T426	4.55	No	No	0	3	3
136	5x34	E2.T427	7.495	No	No	0	5	4
137	5x36	5x40	3.215	No	Yes	1	6	6
138	5x37	5x40	8.165	No	Yes	0	7	6
139	5x39	5x40	4.845	No	Yes	0	8	6
140	5x40	6x57	6.63	Yes	Yes	1	6	5
141	5x40	6x58	8.485	Yes	No	1	6	6
142	5x42	5x46	3.125	Yes	No	0	8	7
143	5x43	6x54	4.52	No	No	0	6	6
144	5x43	6x57	5.025	No	Yes	1	6	5
145	5x44	6x58	3.655	No	No	0	3	6
146	5x47	5x51	8.71	No	No	0	7	3
147	5x47	6x50	4.52	No	No	0	7	9
148	5x49	5x53	3.93	Yes	No	0	5	7
149	5x51	6x47	3.07	No	No	0	3	5
150	5x54	6x43	3.46	Yes	No	0	7	4
151	5x54	6x46	5.255	Yes	No	0	7	6
152	5x57	6x39	3.21	Yes	No	0	7	5
153	5x58	6x39	3.21	No	No	0	5	5
154	5x61	6x35	4.955	No	No	0	7	4
155	5x61	6x39	8.45	No	No	0	7	5
156	5x62	6x36	10.69	No	No	0	3	4
157	5x62	6x40	3.045	No	No	0	3	7
158	5x65	6x36	9.885	No	No	0	5	4
159	I3.R469	I3.V466	7.845	No	No	0	3	3
160	6x52	7x44	9.08	No	No	0	9	5
161	6x53	7x49	6.575	Yes	No	0	9	9
162	6x53	Lig	3.805	Yes	Yes	0	9	0
163	6x57	6x58	4.395	Yes	No	1	5	6
164	E3.P497	E3.T496	3.5	No	No	0	5	7
165	7x41	E3.T496	4.54	Yes	No	0	9	7
166	7x41	E3.L498	3.65	Yes	No	1	9	4
167	E3.L498	Lig	7.445	No	Yes	1	4	0
168	7x37	7x41	4.54	No	Yes	0	7	9
169	7x40	7x44	6.91	No	No	0	7	5
170	7x45	Lig	7.77	No	Yes	1	9	0
171	7x56	7x60	7.4	No	No	0	7	6
172	7x57	7x61	9.285	No	Yes	0	7	6
173	7x60	7x61	16.995	No	Yes	0	6	6
174	I4.L526	I4.P527	3.28	No	No	0	4	6
175	1x63	1x67	4.625	No	No	0	3	5
176	E2.E412	E2.R411	3.49	No	No	0	3	3
177	5x37	E2.M428	3.59	No	No	0	7	5
178	5x59	5x63	3.64	No	No	0	4	5
179	7x41	Lig	5.965	Yes	Yes	1	9	0
180	1x60	7x58	2.95	No	No	0	7	6
181	2x46	2x50	2.93	No	No	0	7	8
182	2x46	3x53	2.93	No	Yes	0	7	7
183	I2.G376	I2.Y374	2.9	No	No	0	5	5
184	4x61	E2.Y403	2.9	No	Yes	0	6	9
185	1x54	7x53	2.85	No	No	0	7	8
186	1x51	2x62	2.825	Yes	No	0	6	5
187	1x50	7x50	2.785	No	No	0	9	9
188	2x53	2x57	2.77	No	No	0	8	8
189	3x51	5x49	2.77	No	Yes	0	8	5
190	4x49	4x491	2.76	No	No	0	4	7
191	E2.E418	E2.L405	2.65	No	No	0	3	4
192	1x48	1x51	2.62	No	Yes	0	5	6
193	3x58	5x57	2.545	No	Yes	0	6	7
194	E2.D410	E3.G499	2.515	No	No	0	4	5
195	5x61	5x62	2.51	No	No	0	7	3
196	7x52	7x56	2.505	No	No	0	6	7
197	5x66	I3.K467	2.475	No	No	0	3	4
198	E2.N413	E2.R409	2.41	No	No	0	4	3
199	7x37	E3.S501	2.4	No	No	0	7	5
200	5x68	I3.V466	2.38	No	No	0	4	3
201	E2.T407	E2.T415	2.355	No	No	0	3	4
202	5x38	5x381	2.28	No	No	0	5	7
203	7x58	7x59	2.28	No	No	0	6	5
204	5x49	5x50	2.26	Yes	No	0	5	9
205	E2.G404	E2.R423	2.25	No	No	0	5	5
206	2x68	E2.L419	2.235	No	No	0	5	5
207	3x54	5x57	2.235	No	Yes	0	8	7
208	7x38	E3.L498	2.235	No	No	0	6	4
209	1x38	1x42	2.205	No	No	0	3	8
210	6x49	7x49	2.15	No	No	0	8	9
211	2x54	2x55	2.11	No	No	0	6	3
212	2x63	3x39	2.08	No	Yes	0	5	7
213	3x28	3x32	2.075	No	Yes	0	2	6
214	E2.L417	E2.L419	2.075	No	No	0	3	5
215	5x54	6x42	2.075	Yes	No	0	7	6
216	7x43	7x47	2.075	No	No	0	8	7
217	1x67	1x68	1.98	No	Yes	0	5	6
218	2x70	3x32	1.98	No	Yes	0	5	6
219	I2.F371	I2.V370	1.965	No	No	0	7	8
220	1x49	1x53	1.965	No	No	0	5	7
221	1x45	1x46	1.95	No	No	0	6	8
222	1x46	7x42	1.95	No	No	0	8	6
223	4x51	4x54	1.95	No	No	0	8	5
224	7x40	7x41	1.885	No	Yes	0	7	9
225	1x46	7x46	1.86	No	No	0	8	8
226	E1.G330	E1.S331	1.86	No	No	0	6	4
227	1x65	I1x51	1.855	No	No	0	7	6
228	I3.G470	I3.V466	1.84	No	No	0	4	3
229	6x55	7x44	1.825	No	No	0	7	5
230	3x48	5x46	1.82	No	No	0	6	7
231	3x60	I2.N372	1.81	No	No	0	6	6
232	1x58	2x55	1.76	No	No	0	6	3
233	1x54	2x54	1.71	No	No	0	7	6
234	2x56	3x43	1.71	No	No	0	7	5
235	6x43	6x44	1.71	No	No	0	4	7
236	7x51	7x55	1.71	No	No	0	6	5
237	1x44	2x69	1.64	No	No	0	4	3
238	3x59	5x57	1.6	No	Yes	0	7	7
239	5x40	5x41	1.59	Yes	No	0	6	5
240	5x60	I2.V370	1.52	No	No	0	6	8
241	3x33	3x36	1.51	No	Yes	0	9	8
242	3x59	5x56	1.49	No	No	0	7	4
243	6x41	6x45	1.475	No	No	0	7	8
244	6x48	6x52	1.475	No	No	0	8	9
245	1x35	E3.L500	1.475	Yes	No	0	5	3
246	3x25	3x26	1.47	No	No	0	4	2
247	E2.G404	E2.Y403	1.45	No	Yes	0	5	9
248	6x34	6x38	1.44	No	No	0	4	6
249	5x51	5x54	1.41	No	Yes	0	3	7
250	5x60	5x64	1.41	No	No	0	6	5
251	6x35	6x38	1.4	No	No	0	4	6
252	1x56	7x54	1.395	No	No	0	4	8
253	4x44	4x48	1.385	No	No	0	5	4
254	3x38	4x54	1.33	Yes	No	0	7	5
255	2x66	3x32	1.31	No	Yes	0	4	6
256	4x41	4x45	1.31	No	No	0	5	7
257	1x35	E2.R414	1.295	Yes	No	0	5	4
258	1x52	1x56	1.255	No	No	0	5	4
259	6x45	7x52	1.22	No	No	0	8	6
260	5x34	5x38	1.21	No	No	0	5	5
261	6x36	I3.E468	1.16	No	No	0	4	4
262	3x28	E1.G333	0.975	No	No	0	2	1
263	4x59	4x62	0.93	No	No	0	5	5
264	E2.G425	E2.M428	0.875	No	No	0	3	5
265	3x25	3x28	0.855	No	No	0	4	2
266	6x56	Lig	0.855	No	Yes	0	7	0
267	1x34	1x36	0.81	No	No	0	1	3
268	6x47	6x51	0.81	No	No	0	5	6
269	1x34	1x35	0.8	No	Yes	0	1	5
270	3x29	E2.L405	0.795	No	No	2	9	4
271	4x41	I2.G376	0.795	No	No	0	5	5
272	E2.L405	E2x50	0.795	No	No	2	4	9
273	2x70	E1.K332	0.765	No	No	0	5	5
274	6x37	6x41	0.75	No	No	0	5	7
275	7x46	7x47	0.75	No	No	0	8	7
276	5x52	5x56	0.745	No	No	0	4	4
277	1x55	2x58	0.695	No	No	0	3	6
278	3x30	3x31	0.65	No	No	0	4	5
279	5x63	5x66	0.645	No	No	0	5	3
280	I2.F371	I2.N372	0.605	No	No	0	7	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg. Int. Strength	Num. Of Links	Community	ConSurf
1	1x35	2.559	5	0	5
2	1x51	4.5775	4	0	6
3	1x61	7.64875	4	0	6
4	1x68	4.635	4	0	6
5	I1x50	5.61	5	3	5
6	2x64	7.652	5	0	9
7	3x32	3.65583	6	2	6
8	3x36	5.57	4	0	8
9	3x37	7.81667	6	1	9
10	3x38	4.812	5	1	7
11	3x39	5.545	4	0	7
12	3x41	5.61	4	1	9
13	3x42	5.52625	4	1	7
14	3x44	5.725	5	1	8
15	3x46	7.293	5	1	9
16	3x53	6.37875	4	0	7
17	3x56	4.64	4	4	6
18	4x42	6.928	5	4	6
19	4x53	4.417	5	1	9
20	4x60	4.769	5	1	7
21	E2.S402	4.205	4	1	4
22	E2.Y403	5.58688	8	1	9
23	E2x51	6.525	7	1	8
24	E2x52	8.856	5	1	7
25	5x40	5.48833	6	1	6
26	5x42	4.63667	6	1	8
27	5x49	3.045	4	0	5
28	5x54	3.05	4	0	7
29	5x57	2.3975	4	0	7
30	6x53	6.09375	4	0	9
31	6x57	5.2675	4	1	5
32	7x41	4.116	5	1	9
33	7x61	11.1187	4	3	6
34	Lig	6.47	7	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	1x35	1x39	24.4431	4.425	Yes	No	0	5	9
2	1x39	E2.L417	26.8234	3.46	No	No	0	9	3
3	E2.L417	E2.L419	29.1919	2.075	No	No	0	3	5
4	2x68	E2.L419	31.5486	2.235	No	No	0	5	5
5	1x40	2x68	12.3656	3.965	No	No	0	6	5
6	2x64	2x68	45.2601	7.87	Yes	No	0	9	5
7	2x64	Lig	53.6468	15.025	Yes	Yes	0	9	0
8	1x47	2x64	29.6503	4.19	No	Yes	0	7	9
9	1x47	2x65	26.6941	7.935	No	No	0	7	7
10	2x64	3x36	31.6074	5.895	Yes	Yes	0	9	8
11	3x36	E2x51	77.4963	7.02	Yes	Yes	0	8	8
12	3x37	E2x51	100	4.235	Yes	Yes	1	9	8
13	3x37	3x41	95.7332	10.93	Yes	Yes	1	9	9
14	3x41	4x53	78.8011	3.285	Yes	Yes	1	9	9
15	3x42	4x53	56.2621	4.71	Yes	Yes	1	7	9
16	3x42	4x50	66.1005	5.22	Yes	No	1	7	9
17	4x47	4x50	41.0226	5.56	No	No	1	5	9
18	4x43	4x47	63.2501	5.285	No	No	0	5	5
19	2x48	4x43	61.8102	11.17	No	No	0	6	5
20	1x65	2x48	60.5701	3.095	No	No	0	7	6
21	1x61	1x65	58.0958	7.2	Yes	No	0	6	7
22	1x61	7x57	26.7881	4.645	Yes	No	0	6	7
23	1x57	7x57	28.134	5.84	No	No	0	8	7
24	1x57	7x54	26.2004	3.38	No	No	0	8	8
25	1x53	7x54	20.3291	6.98	No	No	0	7	8
26	1x49	1x53	14.352	1.965	No	No	0	5	7
27	E2x51	Lig	39.2125	4.425	Yes	Yes	1	8	0
28	6x53	Lig	43.7731	3.805	Yes	Yes	0	9	0
29	3x44	6x53	44.5195	7.015	Yes	Yes	0	8	9
30	3x44	5x42	53.9171	3.61	Yes	Yes	1	8	8
31	3x45	5x42	67.9812	7.49	No	Yes	0	6	8
32	3x45	4x491	83.3852	3.64	No	No	0	6	7
33	3x46	4x491	82.1158	4.22	Yes	No	0	9	7
34	3x46	4x47	23.6497	3.09	Yes	No	1	9	5
35	1x49	7x46	12.3362	4.85	No	No	0	5	8
36	1x51	2x65	24.3256	3.535	Yes	No	0	6	7
37	1x51	2x58	17.1496	9.33	Yes	No	0	6	6
38	1x54	2x58	12.3068	4.26	No	No	0	7	6
39	1x61	I1x50	32.3891	3.61	Yes	Yes	0	6	5
40	1x64	I1x50	17.8607	8.525	No	Yes	0	4	5
41	I1x49	I1x50	13.3118	3.74	No	Yes	0	6	5
42	7x61	I1x50	10.6553	5.675	Yes	Yes	3	6	5
43	7x57	7x61	10.6142	9.285	No	Yes	0	7	6
44	3x46	3x49	85.7009	7.97	Yes	No	0	9	7
45	3x49	4x46	84.3197	3.46	No	No	0	7	7
46	4x42	4x46	83.2031	14.065	Yes	No	0	6	7
47	3x53	4x42	32.3538	7.62	Yes	Yes	0	7	6
48	2x46	3x53	22.68	2.93	No	Yes	0	7	7
49	2x46	2x50	21.4575	2.93	No	No	0	7	8
50	2x50	7x56	21.1108	10.055	No	No	0	8	7
51	3x38	3x39	11.7426	4.645	Yes	Yes	0	7	7
52	3x37	E2.Y403	15.6627	9.255	Yes	Yes	1	9	9
53	4x57	E2.Y403	15.7626	4.42	No	Yes	0	9	9
54	3x38	4x57	15.4569	3.79	Yes	No	0	7	9
55	2x67	3x36	63.6203	7.855	No	Yes	0	6	8
56	2x67	3x32	61.7279	5.425	No	Yes	0	6	6
57	3x29	3x32	21.7867	6.965	No	Yes	2	9	6
58	3x29	E2.L405	19.4123	0.795	No	No	2	9	4
59	E2.E418	E2.L405	34.017	2.65	No	No	0	3	4
60	3x32	E2x50	21.7867	4.18	Yes	No	2	6	9
61	E2.L405	E2x50	19.4123	0.795	No	No	2	4	9
62	3x37	5x381	10.1264	5.48	Yes	No	1	9	7
63	3x44	6x57	10.3908	5.02	Yes	Yes	1	8	5
64	3x56	4x42	65.3365	4.69	Yes	Yes	4	6	6
65	3x55	3x56	63.5322	3.52	No	Yes	0	8	6
66	3x55	3x59	50.2909	10.725	No	No	0	8	7
67	3x59	5x57	45.2718	1.6	No	Yes	0	7	7
68	3x54	5x57	21.5398	2.235	No	Yes	0	8	7
69	3x54	6x42	19.6239	4.845	No	No	0	8	6
70	3x55	3x60	13.8055	3.085	No	No	0	8	6
71	E2.E418	E2.T415	19.5063	3.525	No	No	0	3	4
72	E2.T407	E2.T415	14.6459	2.355	No	No	0	3	4
73	5x36	5x40	11.4428	3.215	No	Yes	1	6	6
74	5x37	5x40	12.9474	8.165	No	Yes	0	7	6
75	5x54	6x42	17.9077	2.075	Yes	No	0	7	6
76	5x51	5x54	10.0735	1.41	No	Yes	0	3	7
77	5x57	6x39	21.5398	3.21	Yes	No	0	7	5
78	5x61	6x39	17.896	8.45	No	No	0	7	5
79	5x61	5x62	10.05	2.51	No	No	0	7	3
80	7x41	Lig	19.4475	5.965	Yes	Yes	1	9	0
81	7x40	7x41	10.0029	1.885	No	Yes	0	7	9
82	7x60	7x61	16.3738	16.995	No	Yes	0	6	6
83	7x56	7x60	14.117	7.4	No	No	0	7	6
84	3x28	3x32	10.0088	2.075	No	Yes	0	2	6
85	3x38	3x42	12.0893	8.735	Yes	Yes	1	7	7
86	3x46	4x50	24.4373	14.055	Yes	No	1	9	9
87	3x45	4x53	19.0949	5.25	No	Yes	0	6	9
88	3x41	5x42	20.0999	4.69	Yes	Yes	1	9	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
1x43	2x64	5.28	0	No	Yes	8	9	2	1
1x47	2x61	6.3	0	No	No	7	7	2	2
1x47	2x64	4.19	0	No	Yes	7	9	2	1
1x50	2x61	8.195	1	No	No	9	7	2	2
1x50	7x45	7.45	1	No	No	9	9	2	1
2x61	7x45	10.215	1	No	No	7	9	2	1
2x64	2x68	7.87	0	Yes	No	9	5	1	2
2x64	3x36	5.895	0	Yes	Yes	9	8	1	2
2x64	Lig	15.025	0	Yes	Yes	9	0	1	0
3x36	E2x51	7.02	0	Yes	Yes	8	8	2	1
3x37	E2x51	4.235	1	Yes	Yes	9	8	2	1
3x37	E2x52	13.575	1	Yes	Yes	9	7	2	2
3x44	6x53	7.015	1	Yes	Yes	8	9	2	1
3x47	6x53	6.98	0	No	Yes	9	9	2	1
E2.Y406	E2x51	6.27	0	No	Yes	2	8	2	1
E2x51	E2x52	15.535	1	Yes	Yes	8	7	1	2
5x36	E2x51	5.125	1	No	Yes	6	8	2	1
5x39	E2x51	3.065	0	No	Yes	8	8	2	1
E2x51	Lig	4.425	1	Yes	Yes	8	0	1	0
5x36	E2x52	7.31	1	No	Yes	6	7	2	2
6x53	7x49	6.575	0	Yes	No	9	9	1	2
6x53	Lig	3.805	0	Yes	Yes	9	0	1	0
7x41	E3.T496	4.54	1	Yes	No	9	7	1	2
7x41	E3.L498	3.65	1	Yes	No	9	4	1	1
E3.L498	Lig	7.445	1	No	Yes	4	0	1	0
7x37	7x41	4.54	0	No	Yes	7	9	2	1
7x45	Lig	7.77	1	No	Yes	9	0	1	0
7x41	Lig	5.965	1	Yes	Yes	9	0	1	0
7x38	E3.L498	2.235	0	No	No	6	4	2	1
7x40	7x41	1.885	0	No	Yes	7	9	2	1
6x56	Lig	0.855	0	No	Yes	7	0	1	0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
27.27	Single	7D77	Hydrocortisone	7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2
25.00	Single	7D76	Beclomethasone	7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
25.00	Single	7XKF	Betahydroxyandrosterone	7XKF-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
25.00	Consensus	go_adhesion	Orthosteric Ligand	7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
25.00	Consensus	go_class-b2	Orthosteric Ligand	go_adhesion
23.08	Consensus	smo_on_allo	Other Ligand	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
22.22	Consensus	adgrg2_on	Orthosteric Ligand	7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
21.43	Single	7UTZ	PubChem 644078	7UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
21.43	Single	7XJJ	Galanin	7XJJ-GAL₁-Galanin-Go/&β;1/&γ;2
21.43	Single	7XOV	SR146131	7XOV-CCK_A-SR146131-Gs/&β;1/&γ;2
21.43	Consensus	go_galanin	Orthosteric Ligand	7XJJ-GAL₁-Galanin-Go/&β;1/&γ;2
20.00	Single	7FIH	Org43553	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
20.00	Single	7V68	PubChem 57664406	7V68-M₄-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
20.00	Single	7WQ3	Galanin	7WQ3-GAL₁-Galanin-Gi1/&β;1/&γ;2
20.00	Consensus	gal1_on	Orthosteric Ligand	7WQ3-GAL₁-Galanin-Gi1/&β;1/&γ;2
20.00	Consensus	gi_galanin	Orthosteric Ligand	7WQ3-GAL₁-Galanin-Gi1/&β;1/&γ;2
20.00	Consensus	smo_off	Orthosteric Ligand	5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
18.75	Single	7T9N	PubChem 644078	7T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
18.75	Single	8FN1	Neurotensin/neuromedin N	8FN1-NTS₁-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
18.75	Single	8JPC	Neurotensin 8-13	8JPC-NTS₁-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
18.75	Single	8SZI	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
17.65	Single	6UP7	Neurotensin	6UP7-NTS₁-Neurotensin-Arrestin2
17.65	Single	7P2L	4YI	7P2L-mGlu₅-4YI
17.65	Single	7XBD	Galanin	7XBD-GAL₂-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.65	Consensus	cck_on	Orthosteric Ligand	ccka_on cckb_on
17.65	Consensus	ccka_on	Orthosteric Ligand	7EZH-CCK_A-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCK_A-SR146131-Gs/&β;1/&γ;2
16.67	Single	6OIK	LY2119620	6OIK-M₂-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
16.67	Single	6OSA	JMV449	6OSA-NTS₁-JMV449-Gi1/&β;1/&γ;2
16.67	Single	6W2Y	PubChem 23727970	6W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
16.67	Single	7K15	MKD046	7K15-BLT₁-MKD046-Na
16.67	Single	7KH0	Acyclovir triphosphate	7KH0-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
16.67	Single	7V6A	PubChem 9864275	7V6A-M₄-PubChem 9864275-Gi1/&β;1/&γ;2
16.67	Single	7WQ4	Galanin	7WQ4-GAL₂-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67	Single	7XJK	Galanin	7XJK-GAL₂-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67	Single	7XW6	ML109	7XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
16.67	Single	8IBU	Erythromycin A	8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
16.67	Single	8U26	Protachykinin-1	8U26-NK₁-Protachykinin-1-Gs/&β;1/&γ;2
16.67	Consensus	blt1_off	Orthosteric Ligand	7K15-BLT₁-MKD046-Na
16.67	Consensus	blt_off	Orthosteric Ligand	blt1_off
16.67	Consensus	galanin_on	Orthosteric Ligand	gal2_on gal1_on
16.67	Consensus	m4_on	Orthosteric Ligand	7TRS-M₄-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M₄-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M₄-PubChem 9864275-Gi1/&β;1/&γ;2
16.00	Single	6FJ3	PTH	6FJ3-PTH1-PTH
15.79	Single	7EZH	Cholecystokinin-8	7EZH-CCK_A-Cholecystokinin-8-Gi1/&β;1/&γ;2
15.79	Single	7EZM	Cholecystokinin-8	7EZM-CCK_A-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
15.79	Single	7P00	Substance P	7P00-NK₁-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.79	Single	8HN1	Toxin AdTx1	8HN1-Alpha1A-Toxin AdTx1
15.79	Consensus	gal2_on	Orthosteric Ligand	7WQ4-GAL₂-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL₂-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.79	Consensus	gs_galanin	Orthosteric Ligand	7WQ4-GAL₂-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL₂-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.38	Single	4MQT	LY2119620	4MQT-M₂-Iperoxo-LY2119620
15.38	Single	6U1N	LY2119620	6U1N-M₂-LY2119620-Arrestin2
15.38	Single	8FX5	Xanomeline	8FX5-M₄-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
15.38	Single	8H8J	Lodoxamide	8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/&β;1/&γ;2
15.38	Single	8JIL	Niacin	8JIL-HCA₂-Niacin-Gi1/&β;1/&γ;2
15.38	Consensus	m4_on_allo	Other Ligand	7TRP-M₄-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M₄-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M₄-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
15.00	Single	4UG2	CGS21680	4UG2-A_2A-CGS21680
15.00	Single	5WF6	UK-432097	5WF6-A_2A-UK-432097
15.00	Single	7F8W	Gastrin-17	7F8W-CCK_B-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
15.00	Single	7W2Z	Ghrelin	7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
15.00	Single	8JBF	Senktide	8JBF-NK₃-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.00	Consensus	gq_cck	Orthosteric Ligand	8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCK_B-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCK_A-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCK_B-Gastrin-Gq/&β;1/&γ;2
15.00	Consensus	nk1_on	Orthosteric Ligand	8U26-NK₁-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK₁-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.81	Consensus	crf1_on	Orthosteric Ligand	6P9X-CRF₁-Corticoliberin-Gs/&β;1/&γ;2
14.29	Single	4BWB	Neurotensin	4BWB-NTS₁-Neurotensin
14.29	Single	5ZKQ	ABT-491	5ZKQ-PAF-ABT-491
14.29	Single	6LFO	Interleukin-8	6LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
14.29	Single	7F8X	NN9056	7F8X-CCK_A-NN9056
14.29	Single	7L0R	Neurotensin	7L0R-NTS₁-Neurotensin-Gi1/&β;1/&γ;1
14.29	Single	7RMH	Substance P	7RMH-NK₁-Substance P-Gs/&β;1/&γ;2
14.29	Single	8FN0	Neurotensin/neuromedin N	8FN0-NTS₁-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
14.29	Single	8J6L	Niacin	8J6L-HCA₂-Niacin-Gi1/&β;1/&γ;2
14.29	Consensus	alpha1a_off	Orthosteric Ligand	7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
14.29	Consensus	m2_on_allo	Other Ligand	7T94-M₂-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M₂-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
13.64	Single	3QAK	UK-432097	3QAK-A_2A-UK-432097
13.64	Single	7EZK	Cholecystokinin-8	7EZK-CCK_A-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
13.64	Consensus	alpha1_off	Orthosteric Ligand	alpha1a_off alpha1b_off
13.64	Consensus	gi_cck	Orthosteric Ligand	7EZH-CCK_A-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCK_B-Gastrin-17-Gi2/&β;1/&γ;2
13.64	Consensus	sst_off	Orthosteric Ligand	sst2_off
13.33	Single	6FFI	MMPEP	6FFI-mGlu₅-MMPEP
13.33	Single	7BB6	Acyclovir triphosphate	7BB6-V₂-Acyclovir triphosphate-Gs/&β;1/&γ;2
13.33	Single	7TRQ	VU0467154	7TRQ-M₄-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
13.33	Single	7XXH	2MeSADP	7XXH-P2Y₁-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
13.33	Single	8HNM	VUF11222	8HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2
13.33	Single	8JD6	N-(3-chlorophenyl)pyridine-2-carboxamide	8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
13.33	Single	8JER	Acipimox	8JER-HCA₂-Acipimox-Go/&β;1/&γ;2
13.33	Single	8JHN	MMF	8JHN-HCA₂-MMF-Go/&β;1/&γ;2
13.33	Single	8JIM	MMF	8JIM-HCA₂-MMF-Gi1/&β;1/&γ;2
13.33	Consensus	cxcr2_on	Orthosteric Ligand	6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
13.33	Consensus	lh_on_allo	Other Ligand	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
13.04	Single	5WF5	UK-432097	5WF5-A_2A-UK-432097
13.04	Single	7W55	Neuromedin-U-25	7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.04	Single	7XNA	CYN154806	7XNA-SST2-CYN154806
13.04	Consensus	gs_tachykinin	Orthosteric Ligand	8U26-NK₁-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK₁-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.04	Consensus	sst2_off	Orthosteric Ligand	7XNA-SST2-CYN154806
13.04	Consensus	tachykinin_on	Orthosteric Ligand	nk1_on nk2_on
12.50	Single	4J4Q	Octyl Beta-D-Glucopyranoside	4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
12.50	Single	5NDD	AZ8838; Na	5NDD-PAR2-AZ8838; Na
12.50	Single	5T04	Neurotensin	5T04-NTS₁-Neurotensin
12.50	Single	5ZKP	Foropafant (SR27417)	5ZKP-PAF-Foropafant (SR27417)
12.50	Single	6FFH	Fenobam	6FFH-mGlu₅-Fenobam
12.50	Single	6NIY	Adrenomedullin	6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
12.50	Single	6ORV	TT-OAD2	6ORV-GLP-1-TT-OAD2-Gs/&β;1/&γ;2
12.50	Single	6Z4V	NTS8-13	6Z4V-NTS₁-NTS8-13
12.50	Single	7AD3	Alpha-factor mating pheromone	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
12.50	Single	7SK8	CXCL12	7SK8-ACKR3-CXCL12-CCX662
12.50	Single	8I7W	GSK256073	8I7W-HCA₂-GSK256073-Gi1/&β;1/&γ;2
12.50	Single	8JII	Niacin	8JII-HCA₂-Niacin-Compound 9n-Gi1/&β;1/&γ;2
12.50	Single	8K5D	GSK256073	8K5D-HCA₂-GSK256073
12.50	Consensus	class-d_on	Orthosteric Ligand	ste2_on
12.50	Consensus	gi_class-d	Orthosteric Ligand	gi_ste
12.50	Consensus	gi_hca	Orthosteric Ligand	8H2G-HCA₂-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA₃-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA₂-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA₂-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA₂-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA₂-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA₂-MMF-Gi1/&β;1/&γ;2 8IJB-HCA₂-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA₂-MK6892-Gi1/&β;1/&γ;2
12.50	Consensus	gi_hcar	Orthosteric Ligand	gi_hca
12.50	Consensus	gi_ste	Orthosteric Ligand	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
12.50	Consensus	hca2_on	Orthosteric Ligand	8H2G-HCA₂-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA₂-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA₂-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA₂-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA₂-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA₂-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA₂-MMF-Gi1/&β;1/&γ;2 8IJB-HCA₂-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA₂-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA₂-GSK256073-Gi1/&β;1/&γ;2
12.50	Consensus	paf_off	Orthosteric Ligand	5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
12.50	Consensus	prostanoid_off	Orthosteric Ligand	ep_off tp_off dp_off
12.00	Single	7F9Y	Ghrelin-28	7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.00	Single	7P02	Protachykinin-1	7P02-NK₁-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
12.00	Consensus	crf2_on	Orthosteric Ligand	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
12.00	Consensus	gs_ghrelin	Orthosteric Ligand	7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.76	Single	4JKV	Taladegib (LY2940680)	4JKV-SMO-Taladegib (LY2940680)
11.76	Single	6LFM	Interleukin-8	6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
11.76	Single	6Z8N	SRI-9829	6Z8N-NTS₁-SRI-9829
11.76	Single	7M3J	NPS-2143; PO4	7M3J-CaS-NPS-2143; PO4
11.76	Single	8J19	PubChem 127045422	8J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
11.54	Single	7F8V	Gastrin-17	7F8V-CCK_B-Gastrin-17-Gi2/&β;1/&γ;2
11.54	Single	7KI0	Semaglutide	7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
11.54	Single	8H0P	NMB30	8H0P-BB₁-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.54	Consensus	bb1_on	Orthosteric Ligand	8H0P-BB₁-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.54	Consensus	class-d_on	Orthosteric Ligand	ste2_on
11.54	Consensus	ctlike_on	Orthosteric Ligand	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
11.54	Consensus	ghrh_on	Orthosteric Ligand	7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
11.54	Consensus	npy4_on	Orthosteric Ligand	7X9C-Y₄-Pancreatic Hormone-Gi1/&β;1/&γ;2
11.43	Single	7TYO	Calcitonin	7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
11.11	Single	3ZEV	Neurotensin	3ZEV-NTS₁-Neurotensin
11.11	Single	4BV0	Neurotensin	4BV0-NTS₁-Neurotensin
11.11	Single	4OO9	Mavoglurant	4OO9-mGlu₅-Mavoglurant
11.11	Single	5V56	TC114	5V56-SMO-TC114
11.11	Single	5V57	TC114	5V57-SMO-TC114
11.11	Single	5XRA	AM11542	5XRA-CB₁-AM11542
11.11	Single	5ZBH	BMS-193885	5ZBH-Y₁-BMS-193885
11.11	Single	6O3C	Cholesterol	6O3C-SMO-SAG21k-Cholesterol
11.11	Single	7AD3	Alpha-factor mating pheromone	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
11.11	Single	7EPE	NAM563	7EPE-mGlu-NAM563
11.11	Single	7L0P	Neurotensin	7L0P-NTS₁-Neurotensin-Gi1/&β;1/&γ;1
11.11	Single	7L0Q	Neurotensin	7L0Q-NTS₁-Neurotensin-Gi1/&β;1/&γ;1
11.11	Single	7PX4	PSB-2113	7PX4-A_2A-PSB-2113
11.11	Single	7SK7	CXCL12	7SK7-ACKR3-CXCL12-CCX662
11.11	Single	7WV9	PubMed 104895	7WV9-CB₁-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
11.11	Single	7XJL	Spexin	7XJL-GAL₂-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.11	Single	7XWO	Neurokinin-A	7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.11	Single	7Y67	C089 peptide	7Y67-C5a₁-C089 peptide-Gi1/&β;1/&γ;2
11.11	Single	7YOO	Neuropeptide Y	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2
11.11	Single	8FMZ	Neurotensin/neuromedin N	8FMZ-NTS₁-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.11	Single	8G05	6-OAU	8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
11.11	Single	8I2G	Compound 716340	8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
11.11	Single	8IHB	GSK256073	8IHB-HCA₂-GSK256073-Gi1/&β;1/&γ;2
11.11	Single	8IHH	LUF6283	8IHH-HCA₂-LUF6283-Gi1/&β;1/&γ;2
11.11	Single	8IYW	GSK256073	8IYW-HCA₂-GSK256073-Go/&β;1/&γ;2
11.11	Single	8JD5	BQI; HZE; PEF	8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
11.11	Single	8T6J	CDPPB	8T6J-mGlu5; mGlu5-CDPPB
11.11	Single	8TAO	CDPPB	8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
11.11	Consensus	arrestin2	Orthosteric Ligand	6TKO-β₁-Arformoterol-Arrestin2 6PWC-NTS₁-Neurotensin-Arrestin2 7R0C-V₂-Acyclovir triphosphate-Arrestin2
11.11	Consensus	gi_class-d	Orthosteric Ligand	gi_ste
11.11	Consensus	gi_muscarinic	Orthosteric Ligand	7TRS-M₄-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M₄-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M₄-PubChem 9864275-Gi1/&β;1/&γ;2
11.11	Consensus	gi_ste	Orthosteric Ligand	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
11.11	Consensus	gs_cgrp	Orthosteric Ligand	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
11.11	Consensus	npy1_off	Orthosteric Ligand	5ZBH-Y₁-BMS-193885 5ZBQ-Y₁-UR-MK-299
11.11	Consensus	nts1_on_allo	Orthosteric Ligand	8JPB-NTS₁-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
11.11	Consensus	relaxin_on	Orthosteric Ligand	rxfp4_on
10.71	Single	7TYW	Calcitonin-1	7TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
10.71	Consensus	gq_peptide	Orthosteric Ligand	gq_cck gq_angiotensin gq_bombesin gq_bradykinin
10.71	Consensus	gs_peptide	Orthosteric Ligand	gs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
10.71	Consensus	peptide_on	Orthosteric Ligand	opioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
10.53	Single	4GRV	Neurotensin 8-13	4GRV-NTS₁-Neurotensin 8-13
10.53	Single	4N4W	SANT-1	4N4W-SMO-SANT-1
10.53	Single	4OR2	FITM	4OR2-mGlu1; mGlu1-FITM
10.53	Single	4XEE	Neurotensin	4XEE-NTS₁-Neurotensin
10.53	Single	4XES	Neurotensin	4XES-NTS₁-Neurotensin
10.53	Single	5X33	BIIL260	5X33-BLT₁-BIIL260
10.53	Single	6C1R	PMX53	6C1R-C5a₁-PMX53-Avacopan; Na
10.53	Single	6KPG	AM841	6KPG-CB₁-AM841-Gi1/&β;1/&γ;2
10.53	Single	6W2Y	PubChem 23727970	6W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
10.53	Single	6XBL	Cholesterol	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
10.53	Single	6YVR	NTS8-13	6YVR-NTS₁-NTS8-13
10.53	Single	7L1U	Orexin	7L1U-OX₂-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.53	Single	7W0N	Elabela	7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
10.53	Single	7XW5	ML109	7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
10.53	Single	7XZ5	Lysophosphatidylcholine	7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
10.53	Single	7Y66	BM213	7Y66-C5a₁-BM213-Gi1/&β;1/&γ;2
10.53	Single	8H0Q	Gastrin Releasing Peptide	8H0Q-BB₂-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.53	Single	8HK2	C3a anaphylatoxin	8HK2-C3a_B-C3a anaphylatoxin-Gi1/&β;1/&γ;2
10.53	Single	8JPB	Neurotensin 8-13	8JPB-NTS₁-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
10.53	Single	8T6J	CDPPB	8T6J-mGlu5; mGlu5-CDPPB
10.53	Consensus	adgrg_on	Orthosteric Ligand	adgrg2_on adgrg3_on
10.53	Consensus	cannabinoid_off	Orthosteric Ligand	cb1_off cb2_off
10.53	Consensus	class-b2_on	Orthosteric Ligand	adgrg_on
10.53	Consensus	gi_class-f	Other Ligand	gi_frizzled
10.53	Consensus	gi_frizzled	Other Ligand	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
10.53	Consensus	gpr119_on	Orthosteric Ligand	7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
10.53	Consensus	nts1_on	Orthosteric Ligand	6OS9-NTS₁-JMV449-Gi1/&β;1/&γ;2
10.53	Consensus	nts_on	Orthosteric Ligand	nts1_on
10.53	Consensus	tsh_on_allo	Other Ligand	7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
10.34	Consensus	gi_peptide	Orthosteric Ligand	gi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
10.34	Consensus	gip_on	Orthosteric Ligand	7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
10.34	Consensus	gip_on_allo	Orthosteric Ligand	7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
10.00	Single	4BUO	Neurotensin	4BUO-NTS₁-Neurotensin
10.00	Single	4OR2	FITM	4OR2-mGlu1; mGlu1-FITM
10.00	Single	6OS9	JMV449	6OS9-NTS₁-JMV449-Gi1/&β;1/&γ;2
10.00	Single	7CX2	PGE2	7CX2-EP₂-PGE2-Gs/&β;1/&γ;2
10.00	Single	7EZC	UKA	7EZC-A_2A-UKA
10.00	Single	7MBY	Cholecystokinin-8	7MBY-CCK_A-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
10.00	Single	7WVV	fMLFII	7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
10.00	Single	7Y65	C5a peptide	7Y65-C5a₁-C5a peptide-Gi1/&β;1/&γ;2
10.00	Single	8JPF	Neurotensin	8JPF-NTS₁-Neurotensin-PubChem 118610427
10.00	Consensus	gi_neurotensin	Orthosteric Ligand	7L0P-NTS₁-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS₁-JMV449-Gi1/&β;1/&γ;2
10.00	Consensus	gs_cck	Orthosteric Ligand	7MBX-CCK_A-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCK_A-SR146131-Gs/&β;1/&γ;2
10.00	Consensus	nk2_on	Orthosteric Ligand	7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.68	Single	8JIR	SAR425899	8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
9.68	Consensus	pth1_on	Orthosteric Ligand	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
9.52	Single	5ZTY	AM10257	5ZTY-CB₂-AM10257
9.52	Single	6C1Q	PMX53	6C1Q-C5a₁-PMX53-NDT9513727
9.52	Single	6OMM	WKYMVX	6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
9.52	Single	6XBJ	Cholesterol	6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
9.52	Single	7F9Z	GHRP-6	7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.52	Single	7NA7	Ghrelin-27	7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
9.52	Single	7RKF	Fractalkine	7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
9.52	Single	7RMG	Substance P	7RMG-NK₁-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
9.52	Single	7S8L	Cortistatin-14	7S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.52	Single	7SK9	CCX662	7SK9-ACKR3-CCX662
9.52	Single	7XN9	L-054,522	7XN9-SST2-L-054,522
9.52	Single	7Y1F	Dynorphin	7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
9.52	Single	7YAE	Octreotide	7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
9.52	Single	8INR	Alpha-MSH	8INR-MC₅-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
9.52	Consensus	c3a_on	Orthosteric Ligand	8HK2-C3a_B-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3a_B-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3a_B-EP141-Go/&β;1/&γ;2 8I95-C3a_B-EP54-Go/&β;1/&γ;2
9.52	Consensus	cb2_off	Orthosteric Ligand	5ZTY-CB₂-AM10257
9.52	Consensus	chemokine_on	Orthosteric Ligand	cxcr_on cx3cr_on
9.52	Consensus	class-d_off	Orthosteric Ligand	ste2_off
9.52	Consensus	fpr2-alx_on	Orthosteric Ligand	7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
9.52	Consensus	go_ghrelin	Orthosteric Ligand	7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
9.52	Consensus	gs_adgr	Orthosteric Ligand	7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
9.52	Consensus	gs_bombesin	Orthosteric Ligand	8H0Q-BB₂-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB₁-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.52	Consensus	gs_class-b2	Orthosteric Ligand	gs_adgr
9.52	Consensus	motilin_on	Orthosteric Ligand	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.38	Single	7TYY	Calcitonin-1	7TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
9.38	Consensus	gi_neuropeptide	Orthosteric Ligand	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y₂-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y₄-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
9.38	Consensus	gs_vip-pacap	Orthosteric Ligand	8E3Y-VPAC₁-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC₁-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2 6M1I-PAC₁-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC₁-PACAP-Gs/&β;1/&γ;2
9.09	Single	4XT1	Fractalkine	4XT1-US28-Fractalkine
9.09	Single	6E3Y	Calcitonin gene-related peptide-1	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
9.09	Single	7F54	Afamelanotide	7F54-MC₄-Afamelanotide-Gs/&β;1/&γ;2
9.09	Single	7QA8	Peptide	7QA8-STE2-Peptide
9.09	Single	7QA8	Peptide	7QA8-STE2-Peptide
9.09	Single	7VLA	CCL15(27-92)	7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
9.09	Single	7WC4	Serotonin	7WC4-5-HT_2A-Serotonin
9.09	Single	7WIC	Somatostatin-14	7WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
9.09	Single	7WKD	TRH	7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.09	Single	7WVW	fMYFINILTL	7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
9.09	Single	7XKE	Betahydroxyandrosterone	7XKE-ADGRG2-Betahydroxyandrosterone-chim(NtGi1-Gs)/&β;1/&γ;2
9.09	Single	7XMR	Somatostatin-14	7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
9.09	Single	8J6R	MK6892	8J6R-HCA₂-MK6892-Gi1/&β;1/&γ;2
9.09	Single	8JZZ	C5a-desArg	8JZZ-C5a₁-C5a-desArg-Go/&β;1/&γ;2
9.09	Single	8U4O	CXCL12	8U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
9.09	Consensus	class-d_off	Orthosteric Ligand	ste2_off
9.09	Consensus	fpr-alx_on	Orthosteric Ligand	fpr1-alx_on fpr2-alx_on
9.09	Consensus	gi_ghrelin	Orthosteric Ligand	7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
9.09	Consensus	gi_relaxin	Orthosteric Ligand	7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
9.09	Consensus	go_class-a	Orthosteric Ligand	go_amine go_peptide go_protein
9.09	Consensus	gs_class-b	Orthosteric Ligand	gs_class-b1 gs_class-b2
9.09	Consensus	nop_on	Orthosteric Ligand	8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
9.09	Consensus	sst2_on	Orthosteric Ligand	7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
9.09	Consensus	sst_on	Orthosteric Ligand	sst2_on sst4_on
8.82	Single	8F2A	Pramlintide analogue san385	8F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
8.70	Single	7C6A	(Sar1,Ile8)-Angiotensin II	7C6A-AT₂-(Sar1,Ile8)-Angiotensin II
8.70	Single	7CUM	Phospholipid	7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid
8.70	Single	7CUM	Phospholipid	7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid
8.70	Single	7F1Q	MIP-1a	7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
8.70	Single	7RKM	Fractalkine	7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
8.70	Single	7RMI	Substance P	7RMI-NK₁-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
8.70	Single	7SK5	CXCL12	7SK5-ACKR3-CXCL12
8.70	Single	7W0N	Elabela	7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
8.70	Single	7WJ5	Somatostatin-14	7WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
8.70	Single	7XBX	CX3CL1	7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
8.70	Single	7XMS	Somatostatin-14	7XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
8.70	Single	8IBV	Motilin	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.70	Consensus	cx3cr_on	Orthosteric Ligand	cx3cr1_on
8.33	Single	6LW5	WKYMVm	6LW5-FPR2-ALX-WKYMVm
8.33	Single	6OT0	25(S)-Epoxycholesterol	6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
8.33	Single	6VN7	PACAP	6VN7-VPAC₁-PACAP-Gs/&β;1/&γ;2
8.33	Single	7F4D	Alpha-MSH	7F4D-MC₁-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
8.33	Single	7F4H	Afamelanotide	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
8.33	Single	7MBX	Cholecystokinin-8	7MBX-CCK_A-Cholecystokinin-8-Gs/&β;1/&γ;1
8.33	Single	7T6T	fMLFII	7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
8.33	Single	7VVN	PTH	7VVN-PTH1-PTH-Gs/&β;1/&γ;2
8.33	Single	7XA3	CCL2	7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
8.33	Single	7XAU	Octreotide	7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
8.33	Single	7XKD	Betahydroxyandrosterone	7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
8.33	Single	7XOU	Cholecystokinin-8	7XOU-CCK_A-Cholecystokinin-8-Gs/&β;1/&γ;2
8.33	Single	8U4Q	REGN7663-Fab	8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/&β;1/&γ;2
8.33	Consensus	ccr2_on	Orthosteric Ligand	7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
8.33	Consensus	ccr_off	Orthosteric Ligand	ccr5_off ccr8_off
8.33	Consensus	cx3cr1_on	Orthosteric Ligand	7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
8.33	Consensus	gi_formylpeptide	Orthosteric Ligand	7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
8.33	Consensus	go_peptide	Orthosteric Ligand	go_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
8.33	Consensus	gs_motilin	Orthosteric Ligand	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.11	Consensus	gs_ct	Orthosteric Ligand	7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
8.00	Single	5WB2	CX3CL1.35	5WB2-US28-CX3CL1.35
8.00	Single	5YQZ	Glucagon analogue	5YQZ-Glucagon-Glucagon analogue
8.00	Single	6JOD	Angiotensin II	6JOD-AT₂-Angiotensin II
8.00	Single	6WIV	PubChem 52923113; PubChem 52924645	6WIV-GABA_B1, GABA_B2-PubChem 52923113; PubChem 52924645
8.00	Single	7DW9	Acyclovir triphosphate	7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
8.00	Single	7RYC	Oxytocin	7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.00	Single	7W40	Bombesin	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
8.00	Single	7YON	Peptide YY(3-36)	7YON-Y₂-Peptide YY(3-36)-Gi1/&β;1/&γ;2
8.00	Single	8IA2	C5a anaphylatoxin	8IA2-C5a₁-C5a anaphylatoxin-Go/&β;1/&γ;2
8.00	Single	8J6I	MK6892	8J6I-HCA₂-MK6892-Gi1/&β;1/&γ;2
8.00	Consensus	ccr1_on	Orthosteric Ligand	7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
8.00	Consensus	compl-peptide_on	Orthosteric Ligand	c5a1_on c3a_on
8.00	Consensus	ghrelin_on	Orthosteric Ligand	7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
8.00	Consensus	gi_somatostatin	Orthosteric Ligand	7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
8.00	Consensus	go_class-b	Orthosteric Ligand	go_class-b1 go_class-b2
8.00	Consensus	nmur2_on	Orthosteric Ligand	7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.00	Consensus	nmur_on	Orthosteric Ligand	nmur1_on nmur2_on
8.00	Consensus	v2_on	Orthosteric Ligand	7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
7.89	Consensus	gs_class-b1	Orthosteric Ligand	gs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
7.69	Single	2ZIY	11-cis-Retinal	2ZIY-Rhodopsin-11-cis-Retinal
7.69	Single	3OE6	IT1t	3OE6-CXCR4-IT1t
7.69	Single	3OE8	IT1t	3OE8-CXCR4-IT1t
7.69	Single	4XNW	MRS2500	4XNW-P2Y₁-MRS2500
7.69	Single	5WKT	Octyl Beta-D-Glucopyranoside	5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
7.69	Single	6ME5	Agomelatine	6ME5-MT₁-Agomelatine
7.69	Single	6X18	GLP-1	6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
7.69	Single	7LLY	Oxyntomodulin	7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
7.69	Single	7QBI	Alpha-factor mating pheromone	7QBI-STE2-Alpha-factor mating pheromone
7.69	Single	7V9M	Somatoliberin	7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
7.69	Single	7VL9	CCL15(26-92)	7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
7.69	Single	7WBJ	PACAP27	7WBJ-VPAC₁-PACAP27-Gs/&β;1/&γ;2
7.69	Single	7WC5	Psilocin	7WC5-5-HT_2A-Psilocin
7.69	Single	7X9B	Neuropeptide Y	7X9B-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2
7.69	Single	7X9C	Pancreatic Hormone	7X9C-Y₄-Pancreatic Hormone-Gi1/&β;1/&γ;2
7.69	Single	7XAT	Somatostatin-14	7XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
7.69	Single	7Y35	Abaloparatide	7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
7.69	Single	7Y64	C5a anaphylatoxin	7Y64-C5a₁-C5a anaphylatoxin-Gi1/&β;1/&γ;2
7.69	Single	8F0J	Pramlintide analogue san45	8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2
7.69	Single	8HCQ	Endothelin-1	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.69	Single	8HCX	Endothelin-1	8HCX-ET_B-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.69	Single	8HK5	Complement C5	8HK5-C5a₁-Complement C5-Gi1/&β;1/&γ;2
7.69	Single	8IW7	2-Phenylethylamine	8IW7-TAAR9-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
7.69	Single	8J24	Acetic acid	8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
7.69	Single	8JGB	Conorfamide-Tx2	8JGB-MRGPRX1-Conorfamide-Tx2-Gi1/&β;1/&γ;2
7.69	Single	8JRV	Glucagon	8JRV-Glucagon-Glucagon-Arrestin2
7.69	Single	8JXT	Histamine	8JXT-H₄-Histamine-PO4-Gi1/&β;1/&γ;2
7.69	Consensus	bk1_on	Orthosteric Ligand	7EIB-BK₁-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.69	Consensus	bombesin_on	Orthosteric Ligand	bb2_on bb1_on
7.69	Consensus	eta_on	Orthosteric Ligand	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.69	Consensus	gs_melanocortin	Orthosteric Ligand	7F4D-MC₁-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC₄-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC₄-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC₄-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC₄-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC₄-THIQ-Gs/&β;1/&γ;2
7.69	Consensus	gs_neuromedin	Orthosteric Ligand	7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.69	Consensus	mc1_on	Orthosteric Ligand	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC₁-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
7.69	Consensus	p2y1_off	Orthosteric Ligand	4XNW-P2Y₁-MRS2500
7.69	Consensus	vpac1_on	Orthosteric Ligand	8E3Y-VPAC₁-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2 6VN7-VPAC₁-PACAP-Gs/&β;1/&γ;2
7.41	Single	4XT3	Fractalkine	4XT3-US28-Fractalkine
7.41	Single	5UIW	5P7-CCL5	5UIW-CCR5-5P7-CCL5
7.41	Single	6NBF	Long-acting PTH analog	6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
7.41	Single	6NBI	Long-acting PTH analog	6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
7.41	Single	7QBI	Alpha-factor mating pheromone	7QBI-STE2-Alpha-factor mating pheromone
7.41	Single	7RGP	Tirzepatide	7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
7.41	Single	7SK3	CXCL12	7SK3-ACKR3-CXCL12
7.41	Single	7SK4	CXCL12_LRHQ	7SK4-ACKR3-CXCL12_LRHQ
7.41	Single	7W3Z	Gastrin Releasing Peptide	7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
7.41	Single	7W57	Neuromedin-S	7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.41	Single	8FLR	PTHrP(1-36)	8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
7.41	Single	8HAO	PTH	8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
7.41	Single	8JIS	Peptide-15	8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
7.41	Consensus	ccr5_off	Orthosteric Ligand	5UIW-CCR5-5P7-CCL5
7.41	Consensus	ccr5_on	Orthosteric Ligand	7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
7.41	Consensus	gi_compl-peptide	Orthosteric Ligand	8HK5-C5a₁-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3a_B-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a₁-BM213-Gi1/&β;1/&γ;2 7Y67-C5a₁-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3a_B-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a₁-C5a peptide-Gi1/&β;1/&γ;2
7.41	Consensus	gi_neuromedin	Orthosteric Ligand	7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
7.41	Consensus	gs_vasopressin-ot	Orthosteric Ligand	7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
7.41	Consensus	kop_on	Orthosteric Ligand	8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
7.41	Consensus	npy2_on	Orthosteric Ligand	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y₂-Peptide YY(3-36)-Gi1/&β;1/&γ;2
7.14	Single	3OE9	IT1t	3OE9-CXCR4-IT1t
7.14	Single	4O9R	Cyclopamine	4O9R-SMO-Cyclopamine
7.14	Single	5L7I	Vismodegib	5L7I-SMO-Vismodegib
7.14	Single	5TE5	20-Methanoretinal	5TE5-Rhodopsin-20-Methanoretinal
7.14	Single	6I9K	9-cis-Retinal	6I9K-Rhodopsin-9-cis-Retinal
7.14	Single	6P9X	Corticoliberin	6P9X-CRF₁-Corticoliberin-Gs/&β;1/&γ;2
7.14	Single	6UVA	Adrenomedullin-2	6UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
7.14	Single	7EIB	Des-Arg10-Kallidin	7EIB-BK₁-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.14	Single	7F4F	Afamelanotide	7F4F-MC₁-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
7.14	Single	7F53	Alpha-MSH	7F53-MC₄-Alpha-MSH-Gs/&β;1/&γ;2
7.14	Single	7QBC	Alpha-factor mating pheromone	7QBC-STE2-Alpha-factor mating pheromone
7.14	Single	7TRP	LY2033298	7TRP-M₄-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
7.14	Single	7UL2	SR48692	7UL2-NTS₁-SR48692-Na
7.14	Single	7VDH	C48/80	7VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
7.14	Single	7VQX	PACAP27	7VQX-VPAC₁-PACAP27-Gs/&β;1/&γ;2
7.14	Single	7VVJ	PTHrP(1-36)	7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
7.14	Single	7WVY	Amyloid-Beta42	7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
7.14	Single	7XK8	Neuromedin-U-25	7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
7.14	Single	7XP6	Strychnine	7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
7.14	Single	7YFC	Histamine	7YFC-H₄-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.14	Single	7YFD	Imetit	7YFD-H₄-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.14	Single	8A2P	LUAA47070	8A2P-A_2A-LUAA47070-Na
7.14	Single	8FU6	Glucagon derivative ZP3780	8FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
7.14	Single	8H2G	Niacin	8H2G-HCA₂-Niacin-Gi1/&β;1/&γ;2
7.14	Single	8HN8	Histamine	8HN8-H₄-Histamine-Gi1/&β;1/&γ;2
7.14	Single	8ITF	DMCHA	8ITF-TAAR9-DMCHA-chim(NtGi1-Gs)/&β;1/&γ;2
7.14	Single	8IY9	Niacin	8IY9-HCA₂-Niacin-Go/&β;1/&γ;2
7.14	Single	8K5B	Niacin	8K5B-HCA₂-Niacin
7.14	Single	8U4R	REGN7663-Fab	8U4R-CXCR4-REGN7663-Fab-Cholesterol
7.14	Consensus	ccr8_on	Orthosteric Ligand	8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
7.14	Consensus	ccr_on	Orthosteric Ligand	ccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
7.14	Consensus	class-t_on	Orthosteric Ligand	taste2_on
7.14	Consensus	endothelin_on	Orthosteric Ligand	etb_on eta_on
7.14	Consensus	etb_on	Orthosteric Ligand	8HCX-ET_B-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ET_B-IRL1620-Gi1/&β;1/&γ;2
7.14	Consensus	glp2_on	Orthosteric Ligand	7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
7.14	Consensus	go_chemokine	Orthosteric Ligand	6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
7.14	Consensus	go_protein	Orthosteric Ligand	go_chemokine
7.14	Consensus	gs_class-t	Orthosteric Ligand	gs_taste
7.14	Consensus	gs_taste	Orthosteric Ligand	7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
7.14	Consensus	mt2_on	Orthosteric Ligand	7VH0-MT₂-Ramelteon-Gi1/&β;1/&γ;1
7.14	Consensus	nts1_off_allo	Orthosteric Ligand	7UL2-NTS₁-SR48692-Na
7.14	Consensus	taste2_on	Orthosteric Ligand	7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
6.90	Single	6B3J	Exendin-P5	6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
6.90	Single	6IGL	IRL1620	6IGL-ET_B-IRL1620
6.90	Single	6NBH	Long-acting PTH analog	6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
6.90	Single	7KI1	Taspoglutide	7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
6.90	Single	7QBC	Alpha-factor mating pheromone	7QBC-STE2-Alpha-factor mating pheromone
6.90	Single	7VGX	Neuropeptide Y	7VGX-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
6.90	Single	7VVL	PTH	7VVL-PTH1-PTH-Gs/&β;1/&γ;2
6.90	Single	8FEG	PRD_002517	8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
6.90	Single	8FLT	M-PTH(1-14)	8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
6.90	Single	8IY5	Endothelin-1	8IY5-ET_B-Endothelin-1-Gi1/&β;1/&γ;2
6.90	Single	8IY6	Endothelin-1	8IY6-ET_B-Endothelin-1
6.90	Consensus	calcitonin_on	Orthosteric Ligand	ct_on ctlike_on
6.90	Consensus	crf_on	Orthosteric Ligand	crf2_on crf1_on
6.90	Consensus	gi_chemokine	Orthosteric Ligand	7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
6.90	Consensus	glp1_on	Orthosteric Ligand	6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
6.90	Consensus	gs_endothelin	Orthosteric Ligand	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ET_B-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.90	Consensus	secretin_on	Orthosteric Ligand	6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
6.90	Consensus	vpac2_on	Orthosteric Ligand	7VQX-VPAC₁-PACAP27-Gs/&β;1/&γ;2
6.67	Single	2X72	All-trans-retinal	2X72-Rhodopsin-All-trans-retinal-Gt(CT)
6.67	Single	2Z73	11-cis-Retinal	2Z73-Rhodopsin-11-cis-Retinal
6.67	Single	3AYN	9-cis-Retinal	3AYN-Rhodopsin-9-cis-Retinal
6.67	Single	3ODU	IT1t	3ODU-CXCR4-IT1t
6.67	Single	3PWH	ZM241385	3PWH-A_2A-ZM241385
6.67	Single	3VG9	ZM241385	3VG9-A_2A-ZM241385-Antibody
6.67	Single	4QIN	SAG1.5	4QIN-SMO-SAG1.5
6.67	Single	4S0V	Suvorexant	4S0V-OX₂-Suvorexant
6.67	Single	5GLH	Endothelin-1	5GLH-ET_B-Endothelin-1
6.67	Single	5K2D	ZM241385	5K2D-A_2A-ZM241385
6.67	Single	5OLO	Tozadenant	5OLO-A_2A-Tozadenant-Na
6.67	Single	5U09	Taranabant	5U09-CB₁-Taranabant
6.67	Single	5VAI	GLP-1	5VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
6.67	Single	6D9H	Adenosine	6D9H-A₁-Adenosine-Gi2/&β;1/&γ;2
6.67	Single	6IGK	Endothelin-3	6IGK-ET_B-Endothelin-3
6.67	Single	6JZH	ZM241385	6JZH-A_2A-ZM241385-Na
6.67	Single	6NWE	Octyl Beta-D-Glucopyranoside	6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
6.67	Single	6O3C	SAG21k	6O3C-SMO-SAG21k-Cholesterol
6.67	Single	6PS7	ZM241385	6PS7-A_2A-ZM241385-Na
6.67	Single	6PWC	Neurotensin	6PWC-NTS₁-Neurotensin-Arrestin2
6.67	Single	6RNK	NF-56-EJ40	6RNK-Succinate-NF-56-EJ40
6.67	Single	6TPJ	Suvorexant	6TPJ-OX₂-Suvorexant
6.67	Single	6WWZ	CCL20	6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
6.67	Single	7DUQ	GLP-1	7DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
6.67	Single	7F8U	Lintitript	7F8U-CCK_A-Lintitript
6.67	Single	7F8Y	Devazepide	7F8Y-CCK_A-Devazepide
6.67	Single	7LCJ	Danuglipron	7LCJ-GLP-1-Danuglipron
6.67	Single	7T8X	Acetylcholine	7T8X-M₂-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
6.67	Single	7T90	Acetylcholine	7T90-M₂-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
6.67	Single	7T94	PubChem 57664406	7T94-M₂-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
6.67	Single	7TYI	Amylin	7TYI-CT-Amylin-Gs/&β;1/&γ;2
6.67	Single	7TYL	Amylin	7TYL-CT-Amylin-Gs/&β;1/&γ;2
6.67	Single	7TYN	Calcitonin-1	7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
6.67	Single	7VIH	CBP-307	7VIH-S1P₁-CBP-307-Gi1/&β;1/&γ;2
6.67	Single	7VV5	C48/80	7VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
6.67	Single	7X2C	Fenoldopam	7X2C-D₁-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
6.67	Single	8GNG	Istradefylline	8GNG-A_2A-Istradefylline
6.67	Single	8HOC	Imetit	8HOC-H₄-Imetit-Gi1/&β;1/&γ;2
6.67	Single	8IHK	Acifran	8IHK-HCA₃-Acifran
6.67	Single	8IJB	Acipimox	8IJB-HCA₂-Acipimox-Gi1/&β;1/&γ;2
6.67	Single	8IW4	Spermidine	8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2
6.67	Single	8IWE	Spermidine	8IWE-TAAR9-Spermidine
6.67	Consensus	bb2_on	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
6.67	Consensus	ccr6_on	Orthosteric Ligand	6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
6.67	Consensus	class-f_off	Orthosteric Ligand	smo_off
6.67	Consensus	cxcr1_on	Orthosteric Ligand	8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
6.67	Consensus	gi_histamine	Orthosteric Ligand	8HN8-H₄-Histamine-Gi1/&β;1/&γ;2 8HOC-H₄-Imetit-Gi1/&β;1/&γ;2
6.67	Consensus	gq_bombesin	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
6.67	Consensus	gs_crf	Orthosteric Ligand	6P9X-CRF₁-Corticoliberin-Gs/&β;1/&γ;2
6.67	Consensus	gs_histamine	Orthosteric Ligand	7YFC-H₄-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H₄-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.67	Consensus	h4_on	Orthosteric Ligand	7YFC-H₄-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H₄-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.67	Consensus	m2_on	Orthosteric Ligand	7T8X-M₂-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
6.45	Single	6WPW	Glucagon derivative ZP3780	6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
6.45	Single	7SK6	CXCL12_LRHQ	7SK6-ACKR3-CXCL12_LRHQ
6.45	Single	7TYH	Calcitonin-1	7TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
6.45	Single	7VBH	Peptide-20	7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
6.45	Single	8FLS	Abaloparatide	8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
6.45	Single	8HBD	IRL1620	8HBD-ET_B-IRL1620-Gi1/&β;1/&γ;2
6.45	Consensus	gi_endothelin	Orthosteric Ligand	8IY5-ET_B-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ET_B-IRL1620-Gi1/&β;1/&γ;2
6.45	Consensus	melanocortin_on	Orthosteric Ligand	mc2_on mc1_on mc3_on mc4_on mc5_on
6.25	Single	2YDO	Adenosine	2YDO-A_2A-Adenosine
6.25	Single	3REY	PubChem 5697	3REY-A_2A-PubChem 5697
6.25	Single	3V2Y	PubChem 51892645	3V2Y-S1P₁-PubChem 51892645
6.25	Single	5IU4	ZM241385	5IU4-A_2A-ZM241385-Na
6.25	Single	5IU7	Q27456346	5IU7-A_2A-Q27456346-Na
6.25	Single	5IUB	Q27456344	5IUB-A_2A-Q27456344-Na
6.25	Single	5JTB	ZM241385	5JTB-A_2A-ZM241385
6.25	Single	5K2B	ZM241385	5K2B-A_2A-ZM241385-Na
6.25	Single	5K2C	ZM241385	5K2C-A_2A-ZM241385-Na
6.25	Single	5NLX	ZM241385	5NLX-A_2A-ZM241385-Na
6.25	Single	5NM4	ZM241385	5NM4-A_2A-ZM241385-Na
6.25	Single	5TE3	Octyl Beta-D-Glucopyranoside	5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
6.25	Single	5UVI	ZM241385	5UVI-A_2A-ZM241385
6.25	Single	6DS0	Ly266097	6DS0-5-HT_2B-Ly266097
6.25	Single	6LRY	Sarafotoxin-B	6LRY-ET_B-Sarafotoxin-B
6.25	Single	6ME3	2-Phenylmelatonin	6ME3-MT₁-2-Phenylmelatonin
6.25	Single	6ME4	2-Iodomelatonin	6ME4-MT₁-2-Iodomelatonin
6.25	Single	6MH8	ZM241385	6MH8-A_2A-ZM241385
6.25	Single	6PT0	WIN 55212-2	6PT0-CB₂-WIN 55212-2-Gi1/&β;1/&γ;2
6.25	Single	6TOS	GSK1059865	6TOS-OX₁-GSK1059865-Na
6.25	Single	6TP3	Nemorexant	6TP3-OX₁-Nemorexant
6.25	Single	6WJC	Atropine	6WJC-M₁-Atropine-Muscarinic toxin 7
6.25	Single	6WJC	Muscarinic toxin 7	6WJC-M₁-Atropine-Muscarinic toxin 7
6.25	Single	6XBL	SAG	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
6.25	Single	6ZA8	RTI-3a	6ZA8-NTS₁-RTI-3a
6.25	Single	6ZDR	HMS1413f12	6ZDR-A_2A-HMS1413f12-Na
6.25	Single	6ZDV	PubChem 984073	6ZDV-A_2A-PubChem 984073-Na
6.25	Single	7C2E	PubChem 149050799	7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
6.25	Single	7CMV	PD128907	7CMV-D₃-PD128907-Gi1/&β;1/&γ;2
6.25	Single	7F61	PF-03654746	7F61-H₃-PF-03654746-Cholesterol
6.25	Single	7T32	ZM241385	7T32-A_2A-ZM241385
6.25	Single	7T94	Acetylcholine	7T94-M₂-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
6.25	Single	7TRS	Acetylcholine	7TRS-M₄-Acetylcholine-Gi1/&β;1/&γ;2
6.25	Single	7TZF	Amylin	7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
6.25	Single	7V35	Peptide-20	7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
6.25	Single	7VOD	Cariprazine	7VOD-5-HT_2A-Cariprazine
6.25	Single	7VV6	C48/80	7VV6-MRGPRX2-C48/80
6.25	Single	7VVM	PTH	7VVM-PTH1-PTH-Gs/&β;1/&γ;2
6.25	Single	7VVO	PTH	7VVO-PTH1-PTH-Gs/&β;1/&γ;2
6.25	Single	7WC9	PubChem 162421364	7WC9-5-HT_2A-PubChem 162421364
6.25	Single	7WVU	fMLF	7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
6.25	Single	7YK6	PubChem 138319674	7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
6.25	Single	7ZI0	SAG	7ZI0-SMO-SAG-Cholesterol
6.25	Single	8GUQ	Olorinab	8GUQ-CB₂-Olorinab-Gi1/&β;1/&γ;2
6.25	Single	8GUR	PubChem 104895	8GUR-CB₂-PubChem 104895-Gi1/&β;1/&γ;2
6.25	Single	8HJ5	PubChem 139030531	8HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.25	Single	8J6P	Niacin	8J6P-HCA₂-Niacin-Compound 9n-Gi1/&β;1/&γ;2
6.25	Single	8K4N	VF0	8K4N-GPR34-VF0-Gi1/&β;1/&γ;2
6.25	Single	8K5C	Acipimox	8K5C-HCA₂-Acipimox
6.25	Single	8U1U	CCL1	8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
6.25	Single	8WC8	ZH8651	8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
6.25	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.25	Consensus	5ht2a_off	Orthosteric Ligand	6A94-5-HT_2A-Zotepine 6WH4-5-HT_2A-Methiothepin 7VOE-5-HT_2A-Aripiprazole 7VOD-5-HT_2A-Cariprazine 7WC8-5-HT_2A-Lumateperone 6A93-5-HT_2A-Risperidone
6.25	Consensus	5ht2a_on	Orthosteric Ligand	7RAN-5-HT_2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT_2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.25	Consensus	cb1_off	Orthosteric Ligand	5TGZ-CB₁-AM6538 5U09-CB₁-Taranabant
6.25	Consensus	cxcr_on	Orthosteric Ligand	cxcr1_on cxcr2_on
6.25	Consensus	ffa2_on	Orthosteric Ligand	8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
6.25	Consensus	ghrelin_off	Orthosteric Ligand	6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
6.25	Consensus	gi_class-f	Orthosteric Ligand	gi_frizzled
6.25	Consensus	gi_frizzled	Orthosteric Ligand	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
6.25	Consensus	gnrh_off	Orthosteric Ligand	gnrh1_off
6.25	Consensus	h3_on_allo	Orthosteric Ligand	7F61-H₃-PF-03654746-Cholesterol
6.25	Consensus	hca_on	Orthosteric Ligand	hca2_on hca3_on
6.25	Consensus	hcar_on	Orthosteric Ligand	hca_on
6.25	Consensus	m1_off_allo	Orthosteric Ligand	6WJC-M₁-Atropine-Muscarinic toxin 7
6.25	Consensus	m1_off_allo	Other Ligand	6WJC-M₁-Atropine-Muscarinic toxin 7
6.25	Consensus	s1p1_off	Orthosteric Ligand	3V2Y-S1P₁-PubChem 51892645
6.25	Consensus	s1p_off	Orthosteric Ligand	s1p1_off
6.25	Consensus	vip-pacap_on	Orthosteric Ligand	vpac1_on vpac2_on pca1_on
6.06	Single	7X9A	Neuropeptide Y	7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
6.06	Single	7Y36	Teriparatide	7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
6.06	Single	8FLQ	PTH	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
6.06	Single	9AUC	Calcitonin gene-related peptide-1	9AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
6.06	Consensus	gs_glucagon	Orthosteric Ligand	6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
6.06	Consensus	mc2_on	Orthosteric Ligand	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
6.06	Consensus	npy1_on	Orthosteric Ligand	7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
6.06	Consensus	npy_on	Orthosteric Ligand	npy2_on npy4_on npy1_on
6.06	Consensus	pth2_on	Orthosteric Ligand	7F16-PTH2-TIP39-Gs/&β;1/&γ;2
5.88	Single	2Y02	Carmoterol	2Y02-β₁-Carmoterol
5.88	Single	3EML	ZM241385	3EML-A_2A-ZM241385
5.88	Single	4DAJ	Tiotropium	4DAJ-M₃-Tiotropium
5.88	Single	4EIY	ZM241385	4EIY-A_2A-ZM241385-Na
5.88	Single	4MQS	Iperoxo	4MQS-M₂-Iperoxo
5.88	Single	4QIM	PubChem 24905375	4QIM-SMO-PubChem 24905375
5.88	Single	4U14	Tiotropium	4U14-M₃-Tiotropium
5.88	Single	4U16	N-Methyl Scopolamine	4U16-M₃-N-Methyl Scopolamine
5.88	Single	4YAY	ZD-7155	4YAY-AT₁-ZD-7155
5.88	Single	5DSG	Tiotropium	5DSG-M₄-Tiotropium
5.88	Single	5IU8	Q27456347	5IU8-A_2A-Q27456347-Na
5.88	Single	5K2A	ZM241385	5K2A-A_2A-ZM241385-Na
5.88	Single	5OLG	ZM241385	5OLG-A_2A-ZM241385-Na
5.88	Single	5TGZ	AM6538	5TGZ-CB₁-AM6538
5.88	Single	5UIG	J3.651.884G	5UIG-A_2A-J3.651.884G
5.88	Single	5VRA	ZM241385	5VRA-A_2A-ZM241385-Na
5.88	Single	5YC8	N-Methyl Scopolamine	5YC8-M₂-N-Methyl Scopolamine
5.88	Single	5ZK8	N-Methyl Scopolamine	5ZK8-M₂-N-Methyl Scopolamine
5.88	Single	5ZKC	N-Methyl Scopolamine	5ZKC-M₂-N-Methyl Scopolamine
5.88	Single	6D27	CAY10471	6D27-DP₂-CAY10471
5.88	Single	6DRX	Lisuride	6DRX-5-HT_2B-Lisuride
5.88	Single	6DRZ	Methysergide	6DRZ-5-HT_2B-Methysergide
5.88	Single	6IIV	Daltroban	6IIV-TP-Daltroban
5.88	Single	6KPF	PubChem 145915889	6KPF-CB₂-PubChem 145915889-Gi1/&β;1/&γ;2
5.88	Single	6LPJ	ZM241385	6LPJ-A_2A-ZM241385-Na
5.88	Single	6LPK	ZM241385	6LPK-A_2A-ZM241385-Na
5.88	Single	6PS8	2-Phenylmelatonin	6PS8-MT₁-2-Phenylmelatonin
5.88	Single	6S0L	ZM241385	6S0L-A_2A-ZM241385
5.88	Single	6TOT	Lemborexant	6TOT-OX₁-Lemborexant
5.88	Single	6WHA	DB13948	6WHA-5-HT_2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.88	Single	6X1A	Danuglipron	6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
5.88	Single	6XBM	25(S)-Epoxycholesterol	6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
5.88	Single	6Z10	PubChem 154585554	6Z10-Succinate-PubChem 154585554
5.88	Single	7EPF	NAM597	7EPF-mGlu2; mGlu2-NAM597
5.88	Single	7F83	PF-05190457	7F83-Ghrelin-PF-05190457
5.88	Single	7LCI	Danuglipron	7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
5.88	Single	7LCK	Danuglipron	7LCK-GLP-1-Danuglipron
5.88	Single	7M3J	NPS-2143; PO4	7M3J-CaS-NPS-2143; PO4
5.88	Single	7NA8	PubChem 178024	7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
5.88	Single	7PYR	PSB-2115	7PYR-A_2A-PSB-2115
5.88	Single	7RBT	PubChem 163183774	7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
5.88	Single	7S15	PubChem 134611223	7S15-GLP-1-PubChem 134611223
5.88	Single	7TRP	Iperoxo	7TRP-M₄-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
5.88	Single	7V3Z	PubMed 104895	7V3Z-CB₁-PubMed 104895
5.88	Single	7VGZ	Remalteon	7VGZ-MT₁-Remalteon-Gi1/&β;1/&γ;2
5.88	Single	7VH0	Ramelteon	7VH0-MT₂-Ramelteon-Gi1/&β;1/&γ;1
5.88	Single	7VIE	S1P	7VIE-S1P₁-S1P-Gi1/&β;1/&γ;2
5.88	Single	7VIF	(S)-FTY720-P	7VIF-S1P₁-(S)-FTY720-P-Gi1/&β;1/&γ;2
5.88	Single	7VKT	LTB4	7VKT-BLT₁-LTB4-Gi1/&β;1/&γ;2
5.88	Single	7WC8	Lumateperone	7WC8-5-HT_2A-Lumateperone
5.88	Single	7YAC	Paltusotine	7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
5.88	Single	8CIC	Etrumadenant	8CIC-A_2A-Etrumadenant-Na
5.88	Single	8EFQ	Damgo	8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
5.88	Single	8EJC	TAK-875	8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
5.88	Single	8EJK	TAK-875	8EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
5.88	Single	8I7V	Acipimox	8I7V-HCA₂-Acipimox-Gi1/&β;1/&γ;2
5.88	Single	8IC0	Interleukin-8	8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
5.88	Single	8J18	(3R)-3-hydroxydodecanoic acid	8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
5.88	Single	8JGG	BAM8-22	8JGG-MRGPRX1-BAM8-22-Gi1/&β;1/&γ;2
5.88	Single	8JT8	(R)-IHCH-7179	8JT8-5-HT_2A-(R)-IHCH-7179
5.88	Single	8X17	Namodenoson	8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
5.88	Consensus	5ht2_off	Orthosteric Ligand	5ht2a_off 5ht2b_off 5ht2c_off
5.88	Consensus	a2_off	Orthosteric Ligand	a2a_off
5.88	Consensus	a2a_off	Orthosteric Ligand	8C9W-A_2A-Etrumadenant 3UZA-A_2A-GTPL9236 8GNG-A_2A-Istradefylline 5UIG-A_2A-J3.651.884G 8CU6-A_2A-LJ-4517 7PX4-A_2A-PSB-2113 7PYR-A_2A-PSB-2115 8DU3-A_2A-PubChem 105526064 8JWY-A_2A-PubChem 168451710 5K2D-A_2A-ZM241385
5.88	Consensus	alpha_off	Orthosteric Ligand	alpha1_off alpha2_off
5.88	Consensus	blt1_on	Orthosteric Ligand	7VKT-BLT₁-LTB4-Gi1/&β;1/&γ;2
5.88	Consensus	blt_on	Orthosteric Ligand	blt1_on
5.88	Consensus	cb1_on_allo	Orthosteric Ligand	7WV9-CB₁-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
5.88	Consensus	cck_off	Orthosteric Ligand	ccka_off
5.88	Consensus	ccka_off	Orthosteric Ligand	7F8Y-CCK_A-Devazepide 7F8U-CCK_A-Lintitript
5.88	Consensus	fsh_on_allo	Other Ligand	8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
5.88	Consensus	gi_leukotriene	Orthosteric Ligand	7VKT-BLT₁-LTB4-Gi1/&β;1/&γ;2
5.88	Consensus	go_muscarinic	Orthosteric Ligand	8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M₂-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
5.88	Consensus	hca3_on	Orthosteric Ligand	8IHJ-HCA₃-Acifran-Gi1/&β;1/&γ;2
5.88	Consensus	hcar_off	Orthosteric Ligand	succinate_off
5.88	Consensus	histamine_on	Orthosteric Ligand	h1_on h4_on
5.88	Consensus	leuko_on	Orthosteric Ligand	blt_on
5.88	Consensus	lipid_off	Orthosteric Ligand	cannabinoid_off leuko_off lpl_off paf_off prostanoid_off
5.88	Consensus	m2_on_allo	Orthosteric Ligand	7T94-M₂-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M₂-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
5.88	Consensus	m4_off	Orthosteric Ligand	5DSG-M₄-Tiotropium
5.88	Consensus	m4_on_allo	Orthosteric Ligand	7TRP-M₄-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M₄-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M₄-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
5.88	Consensus	muscarinic_on	Orthosteric Ligand	m2_on m3_on m4_on m1_on
5.88	Consensus	pth_on	Orthosteric Ligand	pth1_on pth2_on
5.88	Consensus	succinate_off	Orthosteric Ligand	6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
5.88	Consensus	tp_off	Orthosteric Ligand	6IIV-TP-Daltroban 6IIU-TP-Ramatroban
5.56	Single	4WW3	All-trans-retinal	4WW3-Rhodopsin-All-trans-retinal
5.56	Single	4ZJ8	Suvorexant	4ZJ8-OX₁-Suvorexant
5.56	Single	5CGC	HTL14242	5CGC-mGlu₅-HTL14242
5.56	Single	5IUA	Q27456348	5IUA-A_2A-Q27456348-Na
5.56	Single	5N2R	PubChem 92460631; psb36	5N2R-A_2A-PubChem 92460631; psb36-Na
5.56	Single	5N2S	PSB36	5N2S-A₁-PSB36
5.56	Single	5NM2	ZM241385	5NM2-A_2A-ZM241385-Na
5.56	Single	5YHL	PubChem 135121352	5YHL-EP₄-PubChem 135121352
5.56	Single	5YWY	ONO-AE3-208	5YWY-EP₄-ONO-AE3-208
5.56	Single	5ZBQ	UR-MK-299	5ZBQ-Y₁-UR-MK-299
5.56	Single	5ZK3	Quinuclidinyl benzilate hydrobromide	5ZK3-M₂-Quinuclidinyl benzilate hydrobromide
5.56	Single	6D26	Fevipiprant	6D26-DP₂-Fevipiprant
5.56	Single	6GDG	NECA	6GDG-A_2A-NECA-Gs/&β;1/&γ;1
5.56	Single	6KPC	PubChem 145915889	6KPC-CB₂-PubChem 145915889
5.56	Single	6LPL	ZM241385	6LPL-A_2A-ZM241385-Na
5.56	Single	6M9T	Misoprostol-FA	6M9T-EP₃-Misoprostol-FA
5.56	Single	6ME7	2-Phenylmelatonin	6ME7-MT₂-2-Phenylmelatonin
5.56	Single	6N4B	MDMB-Fubinaca	6N4B-CB₁-MDMB-Fubinaca-Gi1/&β;1/&γ;2
5.56	Single	6OIK	Iperoxo	6OIK-M₂-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
5.56	Single	6S0Q	ZM241385	6S0Q-A_2A-ZM241385
5.56	Single	6TO7	Suvorexant	6TO7-OX₁-Suvorexant-Na
5.56	Single	6TP6	Filorexant	6TP6-OX₁-Filorexant
5.56	Single	6W2X	PubChem 23727970	6W2X-GABA_B1, GABA_B2-PubChem 5311042-PubChem 23727970
5.56	Single	6WQA	ZM241385	6WQA-A_2A-ZM241385-Na
5.56	Single	6XBK	Cholesterol	6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
5.56	Single	7BB7	Acyclovir triphosphate	7BB7-V₂-Acyclovir triphosphate-Gs/&β;1/&γ;2
5.56	Single	7C4S	S1P	7C4S-S1P₃-S1P
5.56	Single	7EO2	FTY720-P	7EO2-S1P₁-FTY720-P-Gi1/&β;1/&γ;2
5.56	Single	7EW3	S1P	7EW3-S1P₃-S1P-Gi1/&β;1/&γ;2
5.56	Single	7LD3	Adenosine	7LD3-A₁-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
5.56	Single	7RM5	ZM241385	7RM5-A_2A-ZM241385-Na
5.56	Single	7TD3	S1P	7TD3-S1P₁-S1P-Gi1/&β;1/&γ;2
5.56	Single	7TRK	Iperoxo	7TRK-M₄-Iperoxo-Gi1/&β;1/&γ;2
5.56	Single	7VFX	fMLF	7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
5.56	Single	7VOE	Aripiprazole	7VOE-5-HT_2A-Aripiprazole
5.56	Single	7VV0	PAMP-12	7VV0-MRGPRX2-PAMP-12
5.56	Single	8C9W	Etrumadenant	8C9W-A_2A-Etrumadenant
5.56	Single	8E9Z	Iperoxo	8E9Z-M₃-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.56	Single	8EA0	Iperoxo	8EA0-M₃-Iperoxo
5.56	Single	8EFB	Oliceridine	8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
5.56	Single	8FYN	ZM241385	8FYN-A_2A-ZM241385-Na
5.56	Single	8GDA	L902688	8GDA-EP₄-L902688-Gs/&β;1/&γ;2
5.56	Single	8GDC	PGE2	8GDC-EP₃-PGE2-Gi1/&β;1/&γ;2
5.56	Single	8GNE	KW-6356	8GNE-A_2A-KW-6356-Na
5.56	Single	8HNL	PS372424	8HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2
5.56	Single	8IHJ	Acifran	8IHJ-HCA₃-Acifran-Gi1/&β;1/&γ;2
5.56	Single	8IZ4	Lysophosphatidylserine	8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
5.56	Single	8J6J	GSK256073	8J6J-HCA₂-GSK256073-Gi1/&β;1/&γ;2
5.56	Single	8K8J	Fenofibrate	8K8J-CB₁-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
5.56	Single	8QOT	Nanobody E	8QOT-μ-Nanobody E
5.56	Consensus	5ht2b_off	Orthosteric Ligand	6DRZ-5-HT_2B-Methysergide 6DRX-5-HT_2B-Lisuride
5.56	Consensus	a1_on_allo	Orthosteric Ligand	7LD3-A₁-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
5.56	Consensus	a2a_on	Orthosteric Ligand	6GDG-A_2A-NECA-Gs/&β;1/&γ;1
5.56	Consensus	cb2_on	Orthosteric Ligand	8GUS-CB₂-HU-308-Gi1/&β;1/&γ;2 8GUT-CB₂-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB₂-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB₂-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB₂-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB₂-WIN 55212-2-Gi1/&β;1/&γ;2
5.56	Consensus	d2_on	Orthosteric Ligand	7JVR-D₂-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D₂-Rotigotine-Gi1/&β;1/&γ;2
5.56	Consensus	ep3_on	Orthosteric Ligand	8GDC-EP₃-PGE2-Gi1/&β;1/&γ;2
5.56	Consensus	ep4_off	Orthosteric Ligand	5YWY-EP₄-ONO-AE3-208 5YHL-EP₄-PubChem 135121352
5.56	Consensus	ep_off	Orthosteric Ligand	ep4_off
5.56	Consensus	gq_muscarinic	Orthosteric Ligand	6OIJ-M₁-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
5.56	Consensus	gs_muscarinic	Orthosteric Ligand	8E9W-M₃-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M₃-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.56	Consensus	gs_pth	Orthosteric Ligand	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
5.56	Consensus	m1_on	Orthosteric Ligand	6OIJ-M₁-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
5.56	Consensus	m2_off	Orthosteric Ligand	5ZKB-M₂-AF-DX 384 5ZKC-M₂-N-Methyl Scopolamine 5ZK3-M₂-Quinuclidinyl benzilate hydrobromide
5.56	Consensus	m3_on	Orthosteric Ligand	8E9Z-M₃-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M₃-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.56	Consensus	rxfp4_on	Orthosteric Ligand	7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
5.41	Consensus	class-b1_on	Orthosteric Ligand	glucagon_on calcitonin_on vip-pacap_on pth_on crf_on
5.41	Consensus	glu_on	Orthosteric Ligand	6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
5.26	Single	2YDV	NECA	2YDV-A_2A-NECA
5.26	Single	3UON	Quinuclidinyl benzilate hydrobromide	3UON-M₂-Quinuclidinyl benzilate hydrobromide
5.26	Single	4IAQ	Dihydroergotamine	4IAQ-5-HT_1B-Dihydroergotamine
5.26	Single	4RWA	DIPP-NH2	4RWA-δ-DIPP-NH2
5.26	Single	4RWD	DIPP-NH2	4RWD-δ-DIPP-NH2-Na
5.26	Single	4U15	Tiotropium	4U15-M₃-Tiotropium
5.26	Single	4UHR	CGS21680	4UHR-A_2A-CGS21680
5.26	Single	5G53	NECA	5G53-A_2A-NECA-Gs
5.26	Single	5TZR	-	5TZR-FFA1 (GPR40)-MK8666
5.26	Single	5XR8	AM841	5XR8-CB₁-AM841
5.26	Single	5ZHP	PubChem 134828589	5ZHP-M₃-PubChem 134828589
5.26	Single	5ZKB	AF-DX 384	5ZKB-M₂-AF-DX 384
5.26	Single	6KO5	PubChem 57400002	6KO5-Ghrelin-PubChem 57400002
5.26	Single	6OIJ	Iperoxo	6OIJ-M₁-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
5.26	Single	6OL9	Tiotropium	6OL9-M₅-Tiotropium
5.26	Single	6OS1	TRV026	6OS1-AT₁-TRV026
5.26	Single	6W2X	PubChem 23727970	6W2X-GABA_B1, GABA_B2-PubChem 5311042-PubChem 23727970
5.26	Single	6WGT	LSD	6WGT-5-HT_2A-LSD
5.26	Single	7AUE	Setmelanotide	7AUE-MC₄-Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2
5.26	Single	7B6W	Cyclazosin	7B6W-α_1b-Cyclazosin
5.26	Single	7E2Z	Aripiprazole	7E2Z-5-HT_1A-Aripiprazole-Gi1/&β;1/&γ;2
5.26	Single	7F1T	MIP-1a	7F1T-CCR5-MIP-1a
5.26	Single	7FEE	PubMed 104895	7FEE-CB₁-PubMed 104895-ZCZ011
5.26	Single	7M8W	15r-Methyl-Prostaglandin D2	7M8W-DP₂-15r-Methyl-Prostaglandin D2-Na
5.26	Single	7R0C	Acyclovir triphosphate	7R0C-V₂-Acyclovir triphosphate-Arrestin2
5.26	Single	7S8M	Cortistatin-14	7S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
5.26	Single	7T2H	Lofentanil	7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
5.26	Single	7TRQ	Iperoxo	7TRQ-M₄-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
5.26	Single	7VIG	CBP-307	7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2
5.26	Single	7WVX	Humanin	7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
5.26	Single	7XOW	Gastrin	7XOW-CCK_B-Gastrin-Gq/&β;1/&γ;2
5.26	Single	7XOX	Cholecystokinin-8	7XOX-CCK_B-Cholecystokinin-8-Gq/&β;1/&γ;2
5.26	Single	8EF5	Fentanyl	8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
5.26	Single	8GDB	PGE2	8GDB-EP₄-PGE2-Gs/&β;1/&γ;2
5.26	Single	8GUS	HU-308	8GUS-CB₂-HU-308-Gi1/&β;1/&γ;2
5.26	Single	8HDO	BAY 60-6583	8HDO-A_2B-BAY 60-6583-Gs/&β;1/&γ;2
5.26	Single	8I9A	EP54	8I9A-C3a_B-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.26	Single	8IUK	PGF2-alpha	8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.26	Single	8JD5	BQI; HZE; PEF	8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
5.26	Single	8JT6	(R)-IHCH-7179	8JT6-5-HT_1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
5.26	Single	8JXV	Clozapine	8JXV-H₄-Clozapine-Gi1/&β;1/&γ;2
5.26	Single	8JXW	VUF6884	8JXW-H₄-VUF6884-Gi1/&β;1/&γ;2
5.26	Single	8JXX	Clobenpropit	8JXX-H₄-Clobenpropit-Gi1/&β;1/&γ;2
5.26	Single	8X79	MRE-269	8X79-I2-MRE-269-Gs/&β;1/&γ;2
5.26	Consensus	5ht5_off	Orthosteric Ligand	5ht5a_off
5.26	Consensus	a2b_on	Orthosteric Ligand	8HDP-A_2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A_2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A_2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A_2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
5.26	Consensus	adenosine_off	Orthosteric Ligand	a1_off a2_off
5.26	Consensus	alpha1b_off	Orthosteric Ligand	7B6W-α_1b-Cyclazosin
5.26	Consensus	chemerin_on	Orthosteric Ligand	cml1_on
5.26	Consensus	cml1_on	Orthosteric Ligand	8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
5.26	Consensus	gi_amine	Orthosteric Ligand	gi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
5.26	Consensus	gi_dopamine	Orthosteric Ligand	8IRT-D₃-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D₂-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D₂-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D₃-PD128907-Gi1/&β;1/&γ;2 7CMU-D₃-Pramipexole-Gi1/&β;1/&γ;2
5.26	Consensus	gs_adenosine	Orthosteric Ligand	8HDP-A_2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A_2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A_2A-NECA-Gs/&β;1/&γ;1 7XY7-A_2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A_2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
5.26	Consensus	gs_calcitonin	Orthosteric Ligand	gs_ct gs_cgrp
5.26	Consensus	gs_compl-peptide	Orthosteric Ligand	8I9A-C3a_B-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.26	Consensus	gs_nucleotide	Orthosteric Ligand	gs_adenosine
5.26	Consensus	m3_off	Orthosteric Ligand	4U15-M₃-Tiotropium 4U16-M₃-N-Methyl Scopolamine 5ZHP-M₃-PubChem 134828589
5.26	Consensus	m5_off	Orthosteric Ligand	6OL9-M₅-Tiotropium
5.26	Consensus	muscarinic_off	Orthosteric Ligand	m2_off m3_off m4_off m5_off m1_off
5.26	Consensus	s1p3_on	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/&β;1/&γ;2 7EW4-S1P₃-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P₃-Fingolimod-Gi1/&β;1/&γ;2
5.26	Consensus	sst4_on	Orthosteric Ligand	7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
5.13	Single	8GY7	Corticotropin	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
5.00	Single	3VW7	Vorapaxar; Na	3VW7-PAR1-Vorapaxar; Na
5.00	Single	4AMI	Bucindolol	4AMI-β₁-Bucindolol
5.00	Single	5CXV	Tiotropium	5CXV-M₁-Tiotropium
5.00	Single	6A93	Risperidone	6A93-5-HT_2A-Risperidone
5.00	Single	6AK3	Dinoprostone IPGE2	6AK3-EP₃-Dinoprostone IPGE2
5.00	Single	6DRY	Methylergonovine	6DRY-5-HT_2B-Methylergonovine
5.00	Single	6IIU	Ramatroban	6IIU-TP-Ramatroban
5.00	Single	6KQI	PubMed 104895	6KQI-CB₁-PubMed 104895-ORG27569
5.00	Single	6ME6	2-Phenylmelatonin	6ME6-MT₂-2-Phenylmelatonin
5.00	Single	6MXT	Salmeterol	6MXT-β₂-Salmeterol
5.00	Single	6OS0	Angiotensinogen	6OS0-AT₁-Angiotensinogen
5.00	Single	6OS2	TRV026	6OS2-AT₁-TRV026
5.00	Single	6TKO	Arformoterol	6TKO-β₁-Arformoterol-Arrestin2
5.00	Single	6VMS	Bromoergocryptine	6VMS-D₂-Bromoergocryptine-Gi1/&β;1/&γ;2
5.00	Single	6XOX	Orforglipron	6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
5.00	Single	7D7M	Dinoprostone	7D7M-EP₄-Dinoprostone-Gs/&β;1/&γ;1
5.00	Single	7DFP	Spiperone	7DFP-D₂-Spiperone
5.00	Single	7DH5	Mirabegron	7DH5-β₃-Mirabegron-Gs/&β;1/&γ;2
5.00	Single	7EO4	BAF312	7EO4-S1P₁-BAF312-Gi1/&β;1/&γ;2
5.00	Single	7EW2	Fingolimod	7EW2-S1P₃-Fingolimod-Gi1/&β;1/&γ;2
5.00	Single	7F55	Bremelanotide	7F55-MC₄-Bremelanotide-Gs/&β;1/&γ;2
5.00	Single	7L0S	Neurotensin	7L0S-NTS₁-Neurotensin-Gi1/&β;1/γ1
5.00	Single	7SUS	PubChem 122701908	7SUS-Apelin-PubChem 122701908
5.00	Single	7W0L	PubChem 122701908	7W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
5.00	Single	7WCN	AR231453	7WCN-GPR119-AR231453-Gs/&β;1/&γ;2
5.00	Single	7X1T	Taltirelin	7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.00	Single	7XMT	J-2156	7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
5.00	Single	7XY7	NECA	7XY7-A_2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
5.00	Single	7YMJ	Tamsulosin	7YMJ-Alpha1A-Tamsulosin
5.00	Single	8DWC	Proenkephalin-A	8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.00	Single	8E9W	2-Deoxycytidine	8E9W-M₃-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.00	Single	8GCP	PGE2	8GCP-EP₄-PGE2-Gi1/&β;1/&γ;2
5.00	Single	8GTM	BMK-C203	8GTM-CRF₁-BMK-C203
5.00	Single	8I95	EP54	8I95-C3a_B-EP54-Go/&β;1/&γ;2
5.00	Single	8I9L	C3a anaphylatoxin	8I9L-C3a_B-C3a anaphylatoxin-Go/&β;1/&γ;2
5.00	Single	8IA8	E7 peptide	8IA8-C3a_B-E7 peptide-Gi1/&β;1/&γ;2
5.00	Single	8IRS	Rotigotine	8IRS-D₂-Rotigotine-Gi1/&β;1/&γ;2
5.00	Single	8J6D	EP141	8J6D-C3a_B-EP141-Go/&β;1/&γ;2
5.00	Single	8JGF	BAM8-22	8JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.00	Single	8JJL	Olodaterol	8JJL-β₂-Olodaterol
5.00	Single	8JWY	PubChem 168451710	8JWY-A_2A-PubChem 168451710
5.00	Single	8JWZ	AB928	8JWZ-A_2A-AB928-Na
5.00	Single	8JZ7	MK6892	8JZ7-HCA₂-MK6892-Gi1/&β;1/&γ;2
5.00	Single	8T3Q	DHA	8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.00	Single	8WRB	Lysophosphatidylserine	8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
5.00	Single	8WU1	KCA	8WU1-CB₁-KCA-Arrestin1
5.00	Consensus	cannabinoid_on	Orthosteric Ligand	cb1_on cb2_on
5.00	Consensus	cb1_off_allo	Orthosteric Ligand	6KQI-CB₁-PubMed 104895-ORG27569
5.00	Consensus	cb1_on	Orthosteric Ligand	8GHV-CB₁-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB₁-AM841-Gi1/&β;1/&γ;2 6N4B-CB₁-MDMB-Fubinaca-Gi1/&β;1/&γ;2
5.00	Consensus	chemokine_off	Orthosteric Ligand	cxcr_off
5.00	Consensus	cxcr4_off	Orthosteric Ligand	4RWS-CXCR4-vMIP-II
5.00	Consensus	cxcr_off	Orthosteric Ligand	cxcr4_off
5.00	Consensus	dp2_off	Orthosteric Ligand	6D27-DP₂-CAY10471 6D26-DP₂-Fevipiprant
5.00	Consensus	dp_off	Orthosteric Ligand	dp2_off
5.00	Consensus	ep_on	Orthosteric Ligand	ep4_on ep2_on ep3_on
5.00	Consensus	gi_cannabinoid	Orthosteric Ligand	8GUS-CB₂-HU-308-Gi1/&β;1/&γ;2 8GUT-CB₂-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB₂-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB₂-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB₂-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB₂-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB₁-AM841-Gi1/&β;1/&γ;2 6N4B-CB₁-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB₁-PubChem 145964903-Gi1/&β;1/&γ;2
5.00	Consensus	gs_amine	Orthosteric Ligand	gs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
5.00	Consensus	m1_off	Orthosteric Ligand	5CXV-M₁-Tiotropium
5.00	Consensus	s1p_on	Orthosteric Ligand	s1p3_on s1p5_on s1p1_on s1p2_on
4.76	Single	4NC3	Ergotamine	4NC3-5-HT_2B-Ergotamine
4.76	Single	4RWS	vMIP-II	4RWS-CXCR4-vMIP-II
4.76	Single	5CGD	HTL14242	5CGD-mGlu₅-HTL14242
4.76	Single	5TUD	Ergotamine	5TUD-5-HT_2B-Ergotamine
4.76	Single	5TZY	MK8666; PubChem 127053597	5TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
4.76	Single	5UNG	PubChem 15780052	5UNG-AT₂-PubChem 15780052
4.76	Single	6BQG	Ergotamine	6BQG-5-HT_2C-Ergotamine
4.76	Single	6BQH	Ritanserin	6BQH-5-HT_2C-Ritanserin
4.76	Single	6IBL	Arformoterol	6IBL-β₁-Arformoterol
4.76	Single	6K1Q	IRL2500	6K1Q-ET_B-IRL2500
4.76	Single	7CX4	Evatanepag	7CX4-EP₂-Evatanepag-Gs/&β;1/&γ;2
4.76	Single	7JVR	Bromoergocryptine	7JVR-D₂-Bromoergocryptine-Gi1/&β;1/&γ;2
4.76	Single	7QVM	Oxytocin	7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
4.76	Single	7U2K	C6-guano	7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
4.76	Single	7UM4	AS2674723	7UM4-5-HT_5A-AS2674723
4.76	Single	7X8R	BOC5	7X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
4.76	Single	7XAV	Lanreotide	7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
4.76	Single	7XZ6	APD668	7XZ6-GPR119-APD668-Gs/&β;1/&γ;2
4.76	Single	8E9X	2-Deoxycytidine	8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
4.76	Single	8E9Y	PubChem 446603	8E9Y-M₃-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.76	Single	8FX5	Xanomeline	8FX5-M₄-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
4.76	Single	8GAG	YVF	8GAG-CB₁-YVF-Gi1/&β;1/&γ;2
4.76	Single	8GUT	LEI-102	8GUT-CB₂-LEI-102-Gi1/&β;1/&γ;2
4.76	Single	8ID8	TUG-891	8ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
4.76	Single	8IUL	Latanoprost	8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76	Single	8K2X	CXCL10	8K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
4.76	Single	8WRZ	8D0	8WRZ-CB₁-8D0-Arrestin1
4.76	Single	8XJO	U46619	8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76	Consensus	5ht2c_off	Orthosteric Ligand	6BQH-5-HT_2C-Ritanserin
4.76	Consensus	5ht5a_off	Orthosteric Ligand	7UM4-5-HT_5A-AS2674723
4.76	Consensus	c5a1_off_ortoallo	Orthosteric Ligand	6C1Q-C5a₁-PMX53-NDT9513727 6C1R-C5a₁-PMX53-Avacopan; Na
4.76	Consensus	cckb_on	Orthosteric Ligand	7XOW-CCK_B-Gastrin-Gq/&β;1/&γ;2 7F8W-CCK_B-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
4.76	Consensus	ep2_on	Orthosteric Ligand	7CX4-EP₂-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP₂-PGE2-Gs/&β;1/&γ;2 7CX3-EP₂-Taprenepag-Gs/&β;1/&γ;2
4.76	Consensus	ep4_on	Orthosteric Ligand	7D7M-EP₄-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP₄-PGE2-Gi1/&β;1/&γ;2 8GD9-EP₄-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP₄-L902688-Gs/&β;1/&γ;2
4.76	Consensus	gi_class-a	Orthosteric Ligand	gi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
4.76	Consensus	gs_orexin	Orthosteric Ligand	7L1U-OX₂-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX₂-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX₂-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
4.76	Consensus	orexin_on	Orthosteric Ligand	ox2_on
4.76	Consensus	ot_on	Orthosteric Ligand	7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
4.76	Consensus	s1p1_on	Orthosteric Ligand	7TD3-S1P₁-S1P-Gi1/&β;1/&γ;2 7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P₁-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P₁-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P₁-PubChem 4077460-Gi1/&β;1/&γ;2
4.55	Single	5EE7	MK0893	5EE7-Glucagon-MK0893
4.55	Single	6KNM	JN241-9	6KNM-Apelin-JN241-9
4.55	Single	7F2O	Bradykinin	7F2O-BK₂-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.55	Single	7RKN	Fractalkine	7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
4.55	Single	7X1U	TRH	7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.55	Single	7X8S	WB4-24	7X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
4.55	Single	7XY6	PubChem 11717831	7XY6-A_2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Single	7YJ4	INSL5	7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
4.55	Single	8F7R	Endomorphin	8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
4.55	Single	8IA7	Cholecystokinin-8	8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
4.55	Single	8IUM	Tafluprost acid	8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.55	Single	8IYH	MK6892	8IYH-HCA₂-MK6892-Go/&β;1/&γ;2
4.55	Single	8JLR	A77636	8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Single	8SAI	1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine	8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
4.55	Consensus	fpr1-alx_on	Orthosteric Ligand	7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
4.55	Consensus	gi_apelin	Orthosteric Ligand	7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
4.55	Consensus	gi_lipid	Orthosteric Ligand	gi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
4.55	Consensus	go_compl-peptide	Orthosteric Ligand	8I95-C3a_B-EP54-Go/&β;1/&γ;2 8IA2-C5a₁-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3a_B-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3a_B-EP141-Go/&β;1/&γ;2
4.55	Consensus	go_vasopressin	Orthosteric Ligand	7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
4.55	Consensus	lipid_on	Orthosteric Ligand	cannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
4.55	Consensus	lpl_off	Orthosteric Ligand	s1p_off lpa_off
4.55	Consensus	lpl_on	Orthosteric Ligand	s1p_on lpa_on
4.55	Consensus	mc4_on	Orthosteric Ligand	7F53-MC₄-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC₄-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC₄-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC₄-THIQ-Gs/&β;1/&γ;2 7F54-MC₄-Afamelanotide-Gs/&β;1/&γ;2
4.55	Consensus	ox2_on	Orthosteric Ligand	7L1V-OX₂-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX₂-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX₂-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
4.55	Consensus	protein_on	Orthosteric Ligand	ccr_on chemokine_on gphr_on chemerin_on
4.55	Consensus	ste2_off	Orthosteric Ligand	7QA8-STE2-Peptide
4.35	Single	4AMJ	(S)-Carvedilol	4AMJ-β₁-(S)-Carvedilol
4.35	Single	4IAR	Ergotamine	4IAR-5-HT_1B-Ergotamine
4.35	Single	5UNF	PubChem 15780052	5UNF-AT₂-PubChem 15780052
4.35	Single	5VBL	Apelin Mimetic Peptide Agonist	5VBL-Apelin-Apelin Mimetic Peptide Agonist
4.35	Single	6WIV	PubChem 52923113; PubChem 52924645	6WIV-GABA_B1, GABA_B2-PubChem 52923113; PubChem 52924645
4.35	Single	6X19	CHU-128	6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
4.35	Single	7CX3	Taprenepag	7CX3-EP₂-Taprenepag-Gs/&β;1/&γ;2
4.35	Single	7F4I	SHU9119	7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
4.35	Single	7RTB	Peptide-19	7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
4.35	Single	7TD4	Siponimod	7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2
4.35	Single	7W0P	Elabela	7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
4.35	Single	7W53	Neuromedin-U-25	7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.35	Single	8DCR	Dobutamine	8DCR-β₁-Dobutamine-Gs/&β;1/&γ;2
4.35	Single	8F7X	Nociceptin	8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
4.35	Single	8GHV	PubChem 145964903	8GHV-CB₁-PubChem 145964903-Gi1/&β;1/&γ;2
4.35	Single	8JIQ	Peptide-15	8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
4.35	Single	8XBH	S3E-LysoPS	8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
4.35	Consensus	apelin_on	Orthosteric Ligand	7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
4.35	Consensus	mop_off	Orthosteric Ligand	7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
4.35	Consensus	nmur1_on	Orthosteric Ligand	7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.35	Consensus	protein_off	Orthosteric Ligand	ccr_off chemokine_off gnrh_off
4.35	Consensus	ste2_off	Orthosteric Ligand	7QA8-STE2-Peptide
4.17	Single	4IB4	Ergotamine	4IB4-5-HT_2B-Ergotamine
4.17	Single	5XJM	(Sar1,Ile8)-Angiotensin II	5XJM-AT₂-(Sar1,Ile8)-Angiotensin II
4.17	Single	6DO1	Angiotensin-Like peptide S1I8	6DO1-AT₁-Angiotensin-Like peptide S1I8
4.17	Single	6WHC	Glu16 analog of GCG	6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
4.17	Single	7E14	Orforglipron	7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
4.17	Single	7PIU	Setmelanotide	7PIU-MC₄-Setmelanotide-Gs/&β;1/&γ;2
4.17	Single	7PIV	Setmelanotide	7PIV-MC₄-Setmelanotide-Gs/&β;1/&γ;2
4.17	Single	7VBI	Non-Acylated Tirzepatide	7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
4.17	Single	7W56	Neuromedin-S	7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.17	Single	8DWG	Proenkephalin-A	8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.17	Single	8IOC	Gamma-MSH	8IOC-MC₃-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
4.17	Single	8SG1	Chemerin-9	8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
4.17	Consensus	gi_lpl	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/&β;1/&γ;2 7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P₁-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P₁-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P₃-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P₃-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA₁-LPA-Gi1/&β;1/&γ;2 7YU3-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P₁-PubChem 4077460-Gi1/&β;1/&γ;2
4.17	Consensus	vasopressin-ot_on	Orthosteric Ligand	ot_on v2_on
4.00	Single	3OE0	CVX15	3OE0-CXCR4-CVX15
4.00	Single	6PT2	KGCHM07	6PT2-δ-KGCHM07
4.00	Single	6W25	SHU9119	6W25-MC₄-SHU9119-Ca
4.00	Single	7O7F	(6P4)CCL5	7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
4.00	Single	7TD2	LPA	7TD2-LPA₁-LPA-Gi1/&β;1/&γ;2
4.00	Single	8XZH	MM07	8XZH-Apelin-MM07-Gi1/&β;1/&γ;2
4.00	Consensus	angiotensin_on	Orthosteric Ligand	at1_on
4.00	Consensus	at1_on	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/&β;1/&γ;2
4.00	Consensus	gi_chemerin	Orthosteric Ligand	8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
4.00	Consensus	mc3_on	Orthosteric Ligand	8IOC-MC₃-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
4.00	Consensus	mc5_on	Orthosteric Ligand	8INR-MC₅-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC₅-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
4.00	Consensus	opioid_on	Orthosteric Ligand	kop_on mop_on nop_on dop_on
3.85	Single	6M1I	PACAP	6M1I-PAC₁-PACAP-Gs/&β;1/&γ;2
3.85	Single	6MEO	Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4	6MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
3.85	Single	6MET	Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4	6MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
3.85	Single	7C61	Ergotamine	7C61-5-HT_1B-Ergotamine
3.85	Single	7F6G	SAR1-AngII	7F6G-AT₁-SAR1-AngII-Gq/&β;1/&γ;2
3.85	Single	7FIM	Tirzepatide	7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
3.85	Single	7WUI	IP15	7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
3.85	Single	8HA0	PTH	8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
3.85	Single	8HNK	CXCL11	8HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
3.85	Single	8IHF	MK6892	8IHF-HCA₂-MK6892-Gi1/&β;1/&γ;2
3.85	Single	8XZJ	WN353	8XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
3.85	Consensus	bk2_on	Orthosteric Ligand	7F2O-BK₂-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK₂-Kallidin-Gq/&β;1/&γ;2
3.85	Consensus	gq_angiotensin	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/&β;1/&γ;2
3.85	Consensus	pca1_on	Orthosteric Ligand	6M1I-PAC₁-PACAP-Gs/&β;1/&γ;2
3.85	Consensus	ste2_on	Orthosteric Ligand	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
3.70	Single	7F6H	Bradykinin	7F6H-BK₂-Bradykinin-Gq/&β;1/&γ;2
3.70	Single	7F6I	Kallidin	7F6I-BK₂-Kallidin-Gq/&β;1/&γ;2
3.70	Single	7TRY	Urocortin	7TRY-CRF₂-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
3.70	Single	7YKD	Chemerin-9	7YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
3.70	Single	8E3Y	PACAP27	8E3Y-VPAC₁-PACAP27-Gs/&β;1/&γ;2
3.70	Single	8E3Z	VIP	8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2
3.70	Single	8IOD	PG-901	8IOD-MC₅-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
3.70	Single	8KH5	Lysophosphatidylserine	8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
3.70	Consensus	c5a1_on	Orthosteric Ligand	7Y65-C5a₁-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a₁-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a₁-BM213-Gi1/&β;1/&γ;2 7Y67-C5a₁-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/&β;1/&γ;2
3.70	Consensus	gq_class-a	Orthosteric Ligand	gq_amine gq_peptide
3.70	Consensus	gs_bradykinin	Orthosteric Ligand	7F2O-BK₂-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK₁-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.57	Single	6P9Y	PACAP	6P9Y-PAC₁-PACAP-Gs/&β;1/&γ;2
3.57	Single	7CZ5	Somatoliberin	7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
3.57	Single	7FIY	Tirzepatide	7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
3.57	Single	7RA3	GIP	7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
3.57	Single	7XV3	Lysophosphatidylserine	7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
3.57	Single	8E3X	PACAP27	8E3X-PAC₁-PACAP27-Gs/&β;1/&γ;2
3.57	Consensus	bradykinin_on	Orthosteric Ligand	bk2_on bk1_on
3.57	Consensus	glp1_on_allo	Orthosteric Ligand	6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
3.45	Single	5NX2	GLP-1 (Truncated)	5NX2-GLP-1-GLP-1 (Truncated)
3.45	Single	6LMK	Glucagon	6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
3.45	Single	6VCB	GLP-1	6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
3.45	Single	7DTY	GIP	7DTY-GIP-GIP-Gs/&β;1/&γ;2
3.45	Single	7S1M	Ex4-D-Ala	7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
3.45	Consensus	gi_protein	Orthosteric Ligand	gi_chemokine gi_chemerin
3.45	Consensus	go_class-b1	Orthosteric Ligand	go_crf
3.45	Consensus	go_crf	Orthosteric Ligand	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
3.45	Consensus	ste2_on	Orthosteric Ligand	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
3.33	Single	6LML	Glucagon	6LML-Glucagon-Glucagon
3.33	Single	6PB1	Urocortin	6PB1-CRF₂-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
3.33	Single	6UUS	Adrenomedullin	6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
3.33	Single	7D68	GLP-2	7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
3.33	Single	7VVK	PTH	7VVK-PTH1-PTH-Gs/&β;1/&γ;2
3.33	Single	8HAF	PTHrP(1-36)	8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
3.33	Consensus	gq_bradykinin	Orthosteric Ligand	7F6H-BK₂-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK₂-Kallidin-Gq/&β;1/&γ;2
3.23	Single	6PB0	Urocortin	6PB0-CRF₁-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
3.23	Single	7RBT	Tirzepatide	7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
3.23	Single	7TS0	Urocortin	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
3.23	Single	7TYF	Amylin	7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
3.23	Single	7TYX	Amylin	7TYX-CT (AMY2)-Amylin-Gs/&β;1/&γ;2; RAMP2
3.12	Single	8FLU	Long-acting PTH	8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
3.12	Consensus	glp_on	Orthosteric Ligand	glp1_on glp2_on
3.03	Single	8F0K	Pramlintide analogue san385	8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.94	Single	8JIT	MEDI0382	8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
2.86	Single	8JIU	SAR425899	8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
2.78	Consensus	ct_on	Orthosteric Ligand	7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
2.70	Single	7F16	TIP39	7F16-PTH2-TIP39-Gs/&β;1/&γ;2
2.70	Consensus	glucagon_on	Orthosteric Ligand	gip_on glu_on secretin_on ghrh_on glp_on
2.56	Single	8F2B	Pramlintide analogue san45	8F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3

Consensus Members
	Id	Members
	7D77	7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2
	7D76	7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2

Net Summary
I_min	2.995
Number of Linked Nodes	253
Number of Links	280
Number of Hubs	34
Number of Links mediated by Hubs	134
Number of Communities	4
Number of Nodes involved in Communities	38
Number of Links involved in Communities	53

Path Summary
Number Of Nodes in MetaPath	89
Number Of Links MetaPath	88
Number of Shortest Paths	47531
Length Of Smallest Path	3
Average Path Length	14.2004
Length of Longest Path	30
Minimum Path Strength	0.805
Average Path Strength	5.57508
Maximum Path Strength	14.7575
Minimum Path Correlation	0.7
Average Path Correlation	0.919434
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.54545
Average % Of Corr. Nodes	41.5764
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	44.1394
Maximum Path Hubs %	100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following consensuses:
	Id	Components
	adgrg_on	adgrg2_on adgrg3_on

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Download adgrg3_on.zip

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