Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
11x39 4.79571717
22x33 2.90375434
32x36 6.07437
42x38 7.611526
52x42 8.66528
62x51 3.6825448
72x57 6.00875417
82x60 7.25583617
92x62 6.51625414
102x64 5.55875416
11E1x50 7.9475619
12E1x52 7.194517
133x28 10.0013416
143x29 8.75375415
153x32 6.28687817
163x33 8.6625416
173x37 8.509516
183x39 4.12625419
193x49 10.8538429
203x51 7.31875458
213x54 4.56125408
224x50 7.0025409
234x59 2.055404
24E2 9.89167914
25E2x52 4.3875415
265x43 8.59625415
275x461 5.09625416
285x47 8.41125408
296x26 4.93125405
306x32 5.73625438
316x37 5.066508
326x44 4.86917619
336x48 5.96938818
346x51 7.88833615
356x52 11.3263407
366x54 10.515515
376x55 6.284516
38E3 6.19625413
397x30 6.334514
407x34 11.6563414
417x38 5.791516
427x41 8.432517
437x42 8.184517
447x45 4.18419
457x49 3.49417619
467x53 5.2725409
47Lig 7.923571410
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
17x41 7x42 11.68534.125YesYes177
26x48 7x41 26.407215.035YesYes187
36x44 6x48 20.5199.02YesYes198
46x44 7x49 20.06795.435YesYes199
56x48 7x45 14.39773.09YesYes189
67x45 7x49 14.4572.98YesYes199
71x43 2x57 10.60233.045NoYes067
81x50 2x51 11.33083.435NoYes098
92x50 6x44 21.30682.985NoYes099
103x39 6x48 1003.635YesYes198
112x46 3x39 73.76663.685NoYes099
122x46 3x42 73.74327.555NoNo098
132x45 3x42 36.56128.94NoNo098
142x45 4x46 73.00653.1NoNo097
152x42 4x46 72.44086.045YesNo087
162x42 3x49 60.120912.91YesYes289
172x38 3x49 55.61926.975YesYes269
182x35 2x38 97.63816.68NoYes086
192x35 6x29 48.44933.94NoNo086
202x36 6x29 22.06973.03YesNo376
212x49 3x39 38.09534NoYes089
222x49 4x50 37.89534.94NoYes089
232x45 4x50 37.11726.18NoYes099
243x42 4x49 37.23997.08NoNo088
253x45 4x49 36.82333.87NoNo078
262x42 3x45 36.4377.63YesNo087
272x42 4x42 56.92014.995YesNo287
282x38 4x42 55.879911.645YesNo267
292x34 2x38 12.22895.93NoYes056
302x33 6x29 24.48683.03YesNo346
312x33 6x32 17.16932.92YesYes348
322x36 6x32 17.198312.27YesYes378
332x35 6x30 47.97613.46NoNo088
347x49 7x53 28.36212.905YesYes099
352x43 7x53 26.81428.795NoYes089
362x39 2x43 26.07892.235NoNo088
372x39 3x46 25.72432.235NoNo089
382x59 3x28 18.69529.465NoYes056
392x59 E1x52 17.43569.835NoYes057
40E2x52 Lig 12.25793.15YesYes150
41E2x51 E2x52 11.08665.25NoYes135
423x33 4x57 19.15733.825YesNo067
433x30 4x57 14.91924.16NoNo057
443x30 4x62 10.669910.96NoNo055
453x32 6x51 17.18457.715YesYes175
463x37 5x461 11.56126.995YesYes166
473x36 6x48 20.66944.245NoYes078
483x36 5x461 19.96853.2NoYes076
496x51 6x55 38.070510.805YesYes156
505x43 6x55 10.58995.425YesYes156
516x55 Lig 23.61076.3YesYes160
523x46 6x37 23.13754.155NoYes098
533x47 6x37 14.27633.75NoYes098
543x47 5x57 12.53385.255NoNo097
553x54 6x30 24.65374.28YesNo088
563x54 5x68 14.83225.105YesNo086
576x26 6x30 21.65178.505YesNo058
586x26 I2x50 12.34622.88YesNo059
595x44 6x56 12.77945.16NoNo055
606x56 6x60 10.65615.275NoNo055
615x47 6x48 11.89643.505YesYes088
625x64 5x68 12.36694.34NoNo056
636x28 6x32 14.73433.505NoYes058
646x32 6x35 14.73434.25YesNo087
657x31 Lig 16.16361.665NoYes040
667x31 7x35 11.48397.88NoNo044
676x54 Lig 23.463110.645YesYes150
683x33 5x43 17.009315.275YesYes165
696x51 6x54 25.62637.715YesYes155
702x57 7x42 10.493410.55YesYes177
711x50 2x50 19.463610.095NoNo099
723x28 3x32 23.286510.29YesYes167
736x48 6x51 78.40215.305YesYes185
743x32 7x41 14.040313.185YesYes177
752x42 3x46 10.929311.72YesNo089
763x39 6x44 11.70885.185YesYes199
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
2x647x348.251YesYes6421
2x647x383.6251YesYes6622
3x283x2913.4051YesYes6521
3x294x612.9951YesNo5612
3x294x6512.5751YesNo5511
3x29Lig6.041YesYes5010
4x65E2x525.871NoYes5511
4x65Lig5.0051NoYes5010
E2x51E2x525.251NoYes3521
5x36E2x523.281NoYes5511
E2x52Lig3.151YesYes5010
5x366x589.7451NoNo5311
5x36Lig3.561NoYes5010
5x406x555.011NoYes5611
5x406x587.5351NoNo5311
5x40Lig4.1451NoYes5010
5x436x555.4251YesYes5621
5x446x553.880NoYes5621
6x516x547.7151YesYes5521
6x516x5510.8051YesYes5621
6x547x3415.951YesYes5411
6x547x379.2251YesNo5512
6x547x389.041YesYes5612
6x54Lig10.6451YesYes5010
6x55Lig6.31YesYes6010
6x577x334.9750NoNo5512
6x57Lig10.430NoYes5010
6x58Lig20.0551NoYes3010
6x617x303.0251NoYes3411
6x61Lig5.0851NoYes3010
7x297x304.1250NoYes4421
7x30Lig14.321YesYes4010
7x317x357.880NoNo4412
7x34Lig17.7751YesYes4010
E3E37.661YesYes3322
7x26E35.1251NoYes0322
7x30E34.341YesYes4312
7x267x305.861NoYes0421
7x347x384.651YesYes4612
7x27Lig2.7550NoYes3010
7x31Lig1.6650NoYes4010
7x287x310.630NoNo3421

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Consensusnts1_offOrthosteric Ligand6Z4Q-NTS1-SR142948A 6Z4S-NTS1-SR48692
92.86Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
85.71Single6Z4SSR486926Z4S-NTS1-SR48692
71.43Single6ZINSR486926ZIN-NTS1-SR48692
64.71Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/&β;1/γ1
55.00Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/&β;1/&γ;1
52.63Single4BUONeurotensin4BUO-NTS1-Neurotensin
50.00Single8FMZNeurotensin/neuromedin N8FMZ-NTS1-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
46.67Single7UL2SR486927UL2-NTS1-SR48692-Na
46.67Consensusnts1_off_alloOrthosteric Ligand7UL2-NTS1-SR48692-Na
45.00Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
45.00Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
45.00Consensusgi_neurotensinOrthosteric Ligand7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
44.44Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
42.11Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
42.11Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
41.18Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
40.00Single4GRVNeurotensin 8-134GRV-NTS1-Neurotensin 8-13
40.00Single4XEENeurotensin4XEE-NTS1-Neurotensin
40.00Single4XESNeurotensin4XES-NTS1-Neurotensin
40.00Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/&β;1/&γ;2
40.00Single6YVRNTS8-136YVR-NTS1-NTS8-13
40.00Consensusnts1_onOrthosteric Ligand6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
40.00Consensusnts_onOrthosteric Ligandnts1_on
36.84Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
36.84Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
36.84Single7Y27Somatostatin-147Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
36.84Single8FN1Neurotensin/neuromedin N8FN1-NTS1-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
36.84Single8JPCNeurotensin 8-138JPC-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
36.84Consensusgs_sstOrthosteric Ligand7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
36.00Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
36.00Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
35.71Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
35.29Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
35.00Single4BV0Neurotensin4BV0-NTS1-Neurotensin
35.00Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1
35.00Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/&β;1/&γ;1
35.00Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
35.00Consensuschemerin_onOrthosteric Ligandcml1_on
35.00Consensuscml1_onOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
35.00Consensusnts1_on_alloOrthosteric Ligand8JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
34.78Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
34.62Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
34.62Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
34.62Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
33.33Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
33.33Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Single7Y24Octreotide7Y24-SST2-Octreotide-Go/&β;1/&γ;2
33.33Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Single8JPBNeurotensin 8-138JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
33.33Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
33.33Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
33.33Consensuscx3cr_onOrthosteric Ligandcx3cr1_on
33.33Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
33.33Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
33.33Consensussst_offOrthosteric Ligandsst2_off
32.00Single3OE0CVX153OE0-CXCR4-CVX15
32.00Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
32.00Single7XNACYN1548067XNA-SST2-CYN154806
32.00Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
32.00Consensuscx3cr1_onOrthosteric Ligand7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
32.00Consensusgi_chemerinOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
32.00Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
32.00Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
31.82Consensusc5a1_off_ortoalloOrthosteric Ligand6C1Q-C5a1-PMX53-NDT9513727 6C1R-C5a1-PMX53-Avacopan; Na
31.82Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
31.82Consensusgs_galaninOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
31.58Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
31.25Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
31.25Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
31.25Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
31.03Single8FEGPRD_0025178FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
30.77Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.77Consensusnmur_onOrthosteric Ligandnmur1_on nmur2_on
30.43Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
30.43Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
30.43Consensusgs_bombesinOrthosteric Ligand8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.00Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
30.00Single8ID9Eicosapentaenoic acid8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
30.00Single8QOTNanobody E8QOT-μ-Nanobody E
29.63Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
29.63Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
29.63Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
29.63Consensusgs_bradykininOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.63Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.63Consensusgs_neuromedinOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.17Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
29.17Consensusnmur1_onOrthosteric Ligand7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.03Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
28.57Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
28.57Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
28.57Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
28.57Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
28.57Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2
28.57Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
28.57Consensusffa4_onOrthosteric Ligand8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
28.57Consensusgi_ffaOrthosteric Ligand8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
28.57Consensusgi_neuromedinOrthosteric Ligand7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
28.57Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
28.57Consensusnpy_offOrthosteric Ligandnpy2_off npy1_off
28.00Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.00Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
28.00Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
28.00Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
27.78Single7F8YDevazepide7F8Y-CCKA-Devazepide
27.78Single8FN0Neurotensin/neuromedin N8FN0-NTS1-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
27.78Consensusp2y_offOrthosteric Ligandp2y1_off p2y12_off
27.59Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
27.59Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
27.27Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
27.27Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
27.27Single6OS2TRV0266OS2-AT1-TRV026
27.27Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
27.27Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
27.27Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
27.27Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/&β;1/&γ;2
27.27Single7Y66BM2137Y66-C5a1-BM213-Gi1/&β;1/&γ;2
27.27Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.27Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
26.92Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.92Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
26.92Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
26.67Single7VGXNeuropeptide Y7VGX-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
26.32Single3REYPubChem 56973REY-A2A-PubChem 5697
26.32Single5NLXZM2413855NLX-A2A-ZM241385-Na
26.32Single5UVIZM2413855UVI-A2A-ZM241385
26.32Single6MH8ZM2413856MH8-A2A-ZM241385
26.32Single7AROLUF58337ARO-A2A-LUF5833-Na
26.32Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
26.32Consensuscxcr_onOrthosteric Ligandcxcr1_on cxcr2_on
26.32Consensuslh_on_alloOther Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
26.09Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
26.09Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
26.09Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
26.09Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.09Consensusffa4_on_alloOrthosteric Ligand8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.93Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
25.93Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
25.93Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
25.93Consensusgi_somatostatinOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
25.93Consensusnmur2_onOrthosteric Ligand7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.81Single5GLHEndothelin-15GLH-ETB-Endothelin-1
25.00Single3EMLZM2413853EML-A2A-ZM241385
25.00Single3RFMCaffeine3RFM-A2A-Caffeine
25.00Single5K2AZM2413855K2A-A2A-ZM241385-Na
25.00Single5T04Neurotensin5T04-NTS1-Neurotensin
25.00Single5UENDU1725UEN-A1-DU172
25.00Single5VRAZM2413855VRA-A2A-ZM241385-Na
25.00Single6KNMJN241-96KNM-Apelin-JN241-9
25.00Single6LPJZM2413856LPJ-A2A-ZM241385-Na
25.00Single6LPKZM2413856LPK-A2A-ZM241385-Na
25.00Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
25.00Single6S0LZM2413856S0L-A2A-ZM241385
25.00Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
25.00Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
25.00Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
25.00Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
25.00Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
25.00Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
25.00Single7XN9L-054,5227XN9-SST2-L-054,522
25.00Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
25.00Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
25.00Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
25.00Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
25.00Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
25.00Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/&β;1/&γ;2
25.00Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2 8I95-C3aB-EP54-Go/&β;1/&γ;2
25.00Consensuscck_offOrthosteric Ligandccka_off
25.00Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
25.00Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
25.00Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
25.00Consensusmotilin_onOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
25.00Consensusp2y12_offOrthosteric Ligand4NTJ-P2Y12-AZD1283 7PP1-P2Y12-Selatogrel
25.00Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
24.14Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
24.14Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
24.14Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
24.14Consensusbb1_onOrthosteric Ligand8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
24.14Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
24.14Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
24.14Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
24.00Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
24.00Single8G59TUG-8918G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
24.00Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
23.81Single4NTJAZD12834NTJ-P2Y12-AZD1283
23.81Single5IUAQ274563485IUA-A2A-Q27456348-Na
23.81Single5N2SPSB365N2S-A1-PSB36
23.81Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
23.81Single6LPLZM2413856LPL-A2A-ZM241385-Na
23.81Single6S0QZM2413856S0Q-A2A-ZM241385
23.81Single6WQAZM2413856WQA-A2A-ZM241385-Na
23.81Single7RM5ZM2413857RM5-A2A-ZM241385-Na
23.81Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
23.81Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
23.81Single8FYNZM2413858FYN-A2A-ZM241385-Na
23.81Single8GNEKW-63568GNE-A2A-KW-6356-Na
23.81Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
23.53Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
23.33Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.33Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
23.08Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
23.08Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
23.08Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
23.08Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
22.73Single6J20Aprepitant6J20-NK1-Aprepitant
22.73Single6OS1TRV0266OS1-AT1-TRV026
22.73Single7F1TMIP-1a7F1T-CCR5-MIP-1a
22.73Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
22.73Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.73Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
22.73Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
22.73Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.73Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
22.73Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
22.73Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
22.73Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
22.73Consensus5ht1b_onOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
22.73Consensusgs_compl-peptideOrthosteric Ligand8I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.58Single8IY6Endothelin-18IY6-ETB-Endothelin-1
22.58Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
22.58Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
22.58Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
22.58Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
22.22Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
22.22Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
22.22Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1
22.22Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
22.22Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/&β;1/&γ;2
22.22Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
22.22Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
22.22Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
21.88Single6IGKEndothelin-36IGK-ETB-Endothelin-3
21.88Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
21.74Single4PY02MeSATP4PY0-P2Y12-2MeSATP
21.74Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2
21.74Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.74Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.74Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
21.74Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
21.74Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2
21.74Single8I95EP548I95-C3aB-EP54-Go/&β;1/&γ;2
21.74Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2
21.74Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2
21.74Single8IBUErythromycin A8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.74Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.74Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.74Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
21.74Consensusgs_trhOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
21.74Consensusleuko_offOrthosteric Ligandblt_off cyslt_off
21.74Consensuspeptide_offOrthosteric Ligandopioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
21.74Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
21.43Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
21.43Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
21.05Single3PWHZM2413853PWH-A2A-ZM241385
21.05Single3VGAZM2413853VGA-A2A-ZM241385-Antibody
21.05Single4BWBNeurotensin4BWB-NTS1-Neurotensin
21.05Single5K2DZM2413855K2D-A2A-ZM241385
21.05Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
21.05Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
21.05Single6JZHZM2413856JZH-A2A-ZM241385-Na
21.05Single6PS7ZM2413856PS7-A2A-ZM241385-Na
21.05Single7BR3Elagolix7BR3-GnRH1-Elagolix
21.05Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
21.05Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
21.05Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
21.05Single7W0OElabela7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
21.05Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
21.05Single8GNGIstradefylline8GNG-A2A-Istradefylline
21.05Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
21.05Consensusa2a_off_alloOrthosteric Ligand6ZDR-A2A-HMS1413f12-Na 6GT3-A2A-Imaradenant-Na 8CU7-A2A-LJ-4517-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PubChem 92460631; psb36-Na 5MZJ-A2A-Theophylline-Na 5OLO-A2A-Tozadenant-Na 5OLH-A2A-Vipadenant-Na 5NM4-A2A-ZM241385-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5MZP-A2A-Caffeine-Na 8CIC-A2A-Etrumadenant-Na
21.05Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
20.83Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
20.83Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
20.83Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
20.83Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
20.83Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2
20.83Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
20.83Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
20.83Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
20.83Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
20.83Consensuscckb_onOrthosteric Ligand7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
20.83Consensusgs_orexinOrthosteric Ligand7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
20.83Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.83Consensusorexin_onOrthosteric Ligandox2_on
20.69Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
20.69Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
20.69Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.69Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
20.69Consensusbk1_onOrthosteric Ligand7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.69Consensusbombesin_onOrthosteric Ligandbb2_on bb1_on
20.69Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.59Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
20.00Single3UZCPubChem 1355666093UZC-A2A-PubChem 135566609
20.00Single5IU4ZM2413855IU4-A2A-ZM241385-Na
20.00Single5IU7Q274563465IU7-A2A-Q27456346-Na
20.00Single5IUBQ274563445IUB-A2A-Q27456344-Na
20.00Single5JTBZM2413855JTB-A2A-ZM241385
20.00Single5K2BZM2413855K2B-A2A-ZM241385-Na
20.00Single5K2CZM2413855K2C-A2A-ZM241385-Na
20.00Single5NM4ZM2413855NM4-A2A-ZM241385-Na
20.00Single6AQFZM2413856AQF-A2A-ZM241385
20.00Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
20.00Single6TPKRetosiban6TPK-OT-Retosiban
20.00Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
20.00Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
20.00Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
20.00Single7SK3CXCL127SK3-ACKR3-CXCL12
20.00Single7XJJGalanin7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
20.00Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Single8T3VDHA8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
20.00Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
20.00Consensusfpr2-alx_onOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
20.00Consensusgnrh_offOrthosteric Ligandgnrh1_off
20.00Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
20.00Consensusgo_galaninOrthosteric Ligand7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
20.00Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
20.00Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
20.00Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
20.00Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
20.00Consensusvasopressin-ot_offOrthosteric Ligandot_off
19.35Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
19.35Consensusendothelin_onOrthosteric Ligandetb_on eta_on
19.23Single4IARErgotamine4IAR-5-HT1B-Ergotamine
19.23Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
19.23Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
19.23Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
19.23Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.23Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
19.23Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
19.23Consensusfpr-alx_onOrthosteric Ligandfpr1-alx_on fpr2-alx_on
19.23Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
19.23Consensusmop_offOrthosteric Ligand7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
19.23Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
19.23Consensussst2_onOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
19.23Consensussst_onOrthosteric Ligandsst2_on sst4_on
19.05Single4EIYZM2413854EIY-A2A-ZM241385-Na
19.05Single5IU8Q274563475IU8-A2A-Q27456347-Na
19.05Single5OLGZM2413855OLG-A2A-ZM241385-Na
19.05Single5UIGJ3.651.884G5UIG-A2A-J3.651.884G
19.05Single6D27CAY104716D27-DP2-CAY10471
19.05Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
19.05Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
19.05Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
19.05Single7PYRPSB-21157PYR-A2A-PSB-2115
19.05Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
19.05Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
19.05Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
19.05Single8CU6LJ-45178CU6-A2A-LJ-4517
19.05Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
19.05Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
19.05Consensusa2_offOrthosteric Liganda2a_off
19.05Consensusa2a_offOrthosteric Ligand8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 5UIG-A2A-J3.651.884G 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-PubChem 168451710 5K2D-A2A-ZM241385
19.05Consensusadenosine_onOrthosteric Liganda1_on a2_on
19.05Consensusffa_onOrthosteric Ligandffa4_on ffa1_on ffa2_on ffa3_on
19.05Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
19.05Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
19.05Consensusnucleotide_onOrthosteric Ligandadenosine_on
18.75Single6IGLIRL16206IGL-ETB-IRL1620
18.75Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/&β;1/&γ;2
18.75Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
18.75Consensusgs_endothelinOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.52Single3QAKUK-4320973QAK-A2A-UK-432097
18.52Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
18.52Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
18.52Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
18.52Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/&β;1/&γ;2
18.52Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
18.52Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
18.52Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
18.52Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.52Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
18.52Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
18.52Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
18.18Single5N2RPubChem 92460631; psb365N2R-A2A-PubChem 92460631; psb36-Na
18.18Single5NM2ZM2413855NM2-A2A-ZM241385-Na
18.18Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
18.18Single6DDEDamgo6DDE-μ-Damgo-Gi1/&β;1/&γ;2
18.18Single6GDGNECA6GDG-A2A-NECA-Gs/&β;1/&γ;1
18.18Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
18.18Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
18.18Single7CFNINT-7777CFN-GPBA-INT-777-Gs/&β;1/&γ;2
18.18Single7CKXA776367CKX-D1-A77636-Gs/&β;1/&γ;2
18.18Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
18.18Single7SINNPS-21437SIN-CaS-NPS-2143
18.18Single7SINNPS-21437SIN-CaS-NPS-2143
18.18Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
18.18Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
18.18Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
18.18Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
18.18Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
18.18Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.18Consensusa1_on_alloOrthosteric Ligand7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
18.18Consensusa2a_onOrthosteric Ligand6GDG-A2A-NECA-Gs/&β;1/&γ;1
18.18Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
18.18Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
17.86Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
17.86Single6PT2KGCHM076PT2-δ-KGCHM07
17.86Single6W25SHU91196W25-MC4-SHU9119-Ca
17.86Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
17.86Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
17.86Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;2
17.86Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
17.86Consensusangiotensin_onOrthosteric Ligandat1_on
17.86Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
17.86Consensusgi_formylpeptideOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
17.86Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.86Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
17.65Single8A2OTheophylline8A2O-A2A-Theophylline-Na
17.65Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
17.65Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
17.39Single3SN6BI1671073SN6-β2-BI167107-Gs/&β;1/&γ;2
17.39Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
17.39Single4RWADIPP-NH24RWA-δ-DIPP-NH2
17.39Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
17.39Single6E59L-7607356E59-NK1-L-760735
17.39Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
17.39Single6J21Aprepitant6J21-NK1-Aprepitant
17.39Single7JV5SKF812977JV5-D1-SKF81297-Gs/&β;1/&γ;2
17.39Single7JVPSKF839597JVP-D1-SKF83959-Gs/&β;1/&γ;2
17.39Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
17.39Single7PX4PSB-21137PX4-A2A-PSB-2113
17.39Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
17.39Single7XOWGastrin7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
17.39Single7XOXCholecystokinin-87XOX-CCKB-Cholecystokinin-8-Gq/&β;1/&γ;2
17.39Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
17.39Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2
17.39Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
17.39Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
17.39Consensusa2_onOrthosteric Liganda2a_on a2b_on
17.39Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
17.39Consensusadenosine_offOrthosteric Liganda1_off a2_off
17.39Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
17.39Consensuscck_onOrthosteric Ligandccka_on cckb_on
17.39Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
17.39Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
17.39Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A2A-NECA-Gs/&β;1/&γ;1 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
17.39Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
17.39Consensusnk1_offOrthosteric Ligand6J20-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
17.39Consensussst4_onOrthosteric Ligand7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
17.24Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
17.24Single6JODAngiotensin II6JOD-AT2-Angiotensin II
17.24Single7C61Ergotamine7C61-5-HT1B-Ergotamine
17.24Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
17.24Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
17.24Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
16.67Single3UZAGTPL92363UZA-A2A-GTPL9236
16.67Single4XNWMRS25004XNW-P2Y1-MRS2500
16.67Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
16.67Single6MXTSalmeterol6MXT-β2-Salmeterol
16.67Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
16.67Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
16.67Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Single7S8O(R)-Zinc-35737S8O-MRGPRX2-(R)-Zinc-3573-Gi1/&β;1/&γ;2
16.67Single7XMTJ-21567XMT-SST4-J-2156-Gi1/&β;1/&γ;2
16.67Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
16.67Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single7YITNalfurafine7YIT-κ-Nalfurafine
16.67Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
16.67Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
16.67Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
16.67Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/&β;1/&γ;2
16.67Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
16.67Consensuschemokine_offOrthosteric Ligandcxcr_off
16.67Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II
16.67Consensuscxcr_offOrthosteric Ligandcxcr4_off
16.67Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
16.67Consensusdp_offOrthosteric Liganddp2_off
16.67Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
16.67Consensusgo_5htOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
16.67Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
16.67Consensusgs_melanocortinOrthosteric Ligand7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2
16.67Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
16.67Consensustsh_on_alloOther Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
16.00Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
16.00Single6DDFDamgo6DDF-μ-Damgo-Gi1/&β;1/&γ;2
16.00Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
16.00Single7EZCUKA7EZC-A2A-UKA
16.00Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
16.00Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
16.00Single8ID8TUG-8918ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
16.00Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
16.00Single8WRZ8D08WRZ-CB1-8D0-Arrestin1
16.00Consensuscyslt2_offOrthosteric Ligand6RZ6-CysLT2-ONO-2570366 6RZ9-CysLT2-ONO-2770372 6RZ8-CysLT2-ONO-2080365
16.00Consensuscyslt_offOrthosteric Ligandcyslt2_off
16.00Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
16.00Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
15.79Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
15.79Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
15.79Single6HLLCP999946HLL-NK1-CP99994
15.79Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
15.79Single7S8N(R)-Zinc-35737S8N-MRGPRX2-(R)-Zinc-3573-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.79Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
15.79Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
15.79Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
15.79Single8GH1Epinephrine8GH1-β2-Epinephrine
15.62Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
15.62Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
15.62Consensusetb_onOrthosteric Ligand8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
15.38Single3NY9PubChem 9131033NY9-β2-PubChem 913103
15.38Single5WF6UK-4320975WF6-A2A-UK-432097
15.38Single6PT3DPI-2876PT3-δ-DPI-287
15.38Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
15.38Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
15.38Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
15.38Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
15.38Single7XY6PubChem 117178317XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
15.38Single8SAI1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
15.38Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
15.38Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
15.38Consensusgo_vasopressinOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
15.38Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.00Single3VG9ZM2413853VG9-A2A-ZM241385-Antibody
15.00Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/&β;1/&γ;2
15.00Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
15.00Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
15.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
15.00Single7F8ULintitript7F8U-CCKA-Lintitript
15.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
15.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
15.00Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
15.00Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
15.00Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
15.00Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/&β;1/&γ;2
15.00Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
15.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
15.00Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.00Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
15.00Consensusffa3_on_alloOrthosteric Ligand8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
15.00Consensusm2_on_alloOther Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
14.81Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
14.81Single7F8XNN90567F8X-CCKA-NN9056
14.81Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
14.81Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
14.81Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
14.81Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
14.81Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
14.81Single8GHVPubChem 1459649038GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
14.81Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
14.81Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
14.81Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
14.29Single4DKLBeta-funaltrexamine4DKL-μ-Beta-funaltrexamine
14.29Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
14.29Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
14.29Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
14.29Single6HLOAprepitant6HLO-NK1-Aprepitant
14.29Single6V9SGTPL114036V9S-OX1-GTPL11403
14.29Single6ZDVPubChem 9840736ZDV-A2A-PubChem 984073-Na
14.29Single7BB6Acyclovir triphosphate7BB6-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
14.29Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
14.29Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
14.29Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
14.29Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.29Single7VV6C48/807VV6-MRGPRX2-C48/80
14.29Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
14.29Single7XOVSR1461317XOV-CCKA-SR146131-Gs/&β;1/&γ;2
14.29Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
14.29Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Single8HQN9(S)-HODE8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
14.29Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Single8K4NVF08K4N-GPR34-VF0-Gi1/&β;1/&γ;2
14.29Single8UO2Epinephrine8UO2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
14.29Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Consensusalpha1_offOrthosteric Ligandalpha1a_off alpha1b_off
14.29Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
14.29Consensusdop_off_alloOrthosteric Ligand4N6H-δ-Naltrindole-Na
14.29Consensusffa2_onOrthosteric Ligand8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
14.29Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
14.29Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
13.89Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
13.79Single5WF5UK-4320975WF5-A2A-UK-432097
13.79Single7F4DAlpha-MSH7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
13.79Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
13.79Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
13.79Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
13.79Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
13.79Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
13.79Consensusmc5_onOrthosteric Ligand8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
13.64Single4EJ4Naltrindole4EJ4-δ-Naltrindole
13.64Single4QIMPubChem 249053754QIM-SMO-PubChem 24905375
13.64Single4YAYZD-71554YAY-AT1-ZD-7155
13.64Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
13.64Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
13.64Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
13.64Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
13.64Single6PS1Timolol6PS1-β2-Timolol
13.64Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
13.64Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
13.64Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
13.64Single7UL4Alvimopan7UL4-μ-Alvimopan
13.64Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
13.64Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
13.64Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
13.64Single8GEHEpinephrine8GEH-β2-Epinephrine-Gs/&β;1/&γ;2
13.64Single8GGBEpinephrine8GGB-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
13.64Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/&β;1/&γ;2
13.64Single8UNMEpinephrine8UNM-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
13.64Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
13.64Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
13.64Consensusffa1_onOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.64Consensusfsh_on_alloOther Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
13.64Consensustachykinin_offOrthosteric Ligandnk1_off
13.51Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
13.33Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
13.33Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
13.33Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
13.33Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
13.33Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.33Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
13.33Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
13.04Single4PHUFasiglifam4PHU-FFA1 (GPR40)-Fasiglifam
13.04Single5WQCEMPA5WQC-OX2-EMPA
13.04Single5X7D(S)-Carazolol5X7D-β2-(S)-Carazolol-PubChem 129318963
13.04Single6D26Fevipiprant6D26-DP2-Fevipiprant
13.04Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
13.04Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
13.04Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
13.04Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
13.04Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
13.04Single7SBFPZM217SBF-μ-PZM21-Gi1/&β;1/&γ;2
13.04Single7XKAEpinephrine7XKA-β2-Epinephrine
13.04Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
13.04Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
13.04Single8DZQmomSalB8DZQ-κ-momSalB-Go/&β;1/&γ;2
13.04Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
13.04Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
13.04Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
13.04Single8UNYEpinephrine8UNY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
13.04Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.04Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
13.04Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRR-D1-Rotigotine-Gs/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
13.04Consensusgo_opioidOrthosteric Ligand8DZQ-κ-momSalB-Go/&β;1/&γ;2
13.04Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
12.90Single7KH0Acyclovir triphosphate7KH0-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
12.90Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Single3P0GBI1671073P0G-β2-BI167107
12.50Single4XT3Fractalkine4XT3-US28-Fractalkine
12.50Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
12.50Single5MZPCaffeine5MZP-A2A-Caffeine-Na
12.50Single5TZR-5TZR-FFA1 (GPR40)-MK8666
12.50Single5X93K-87945X93-ETB-K-8794
12.50Single5XRAAM115425XRA-CB1-AM11542
12.50Single6H7JIsoprenaline6H7J-β1-Isoprenaline
12.50Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
12.50Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
12.50Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
12.50Single6NI3BI1671076NI3-β2-BI167107-Gs/&β;1/&γ;2
12.50Single7B6WCyclazosin7B6W-α1b-Cyclazosin
12.50Single7CKYPW04647CKY-D1-PW0464-Gs/&β;1/&γ;2
12.50Single7FEEPubMed 1048957FEE-CB1-PubMed 104895-ZCZ011
12.50Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2
12.50Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
12.50Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
12.50Single7TUYGSK682753A7TUY-GPR183-GSK682753A
12.50Single7W41PD1762527W41-BB2-PD176252
12.50Single7WV9PubMed 1048957WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
12.50Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/&β;1/&γ;2
12.50Single8DZPmomSalB8DZP-κ-momSalB-Gi1/&β;1/&γ;2
12.50Single8E0GBU728E0G-μ-BU72
12.50Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
12.50Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.50Consensus5ht5_offOrthosteric Ligand5ht5a_off
12.50Consensusalpha1b_offOrthosteric Ligand7B6W-α1b-Cyclazosin
12.50Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
12.50Consensusbombesin_offOrthosteric Ligandbb2_off
12.50Consensuscyslt1_off_ortoalloOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
12.50Consensusgi_dopamineOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
12.50Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2
12.50Consensusgs_ffaOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2 8GDB-EP4-PGE2-Gs/&β;1/&γ;2
12.50Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
12.50Consensuslpa_offOrthosteric Ligandlpa1_off
12.50Consensuslpa_onOrthosteric Ligandlpa1_on
12.50Consensusrelaxin_onOrthosteric Ligandrxfp4_on
12.12Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
12.12Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
12.00Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
12.00Single4LDEBI1671074LDE-β2-BI167107
12.00Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
12.00Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
12.00Single6HLPNetupitant6HLP-NK1-Netupitant
12.00Single6KQIPubMed 1048956KQI-CB1-PubMed 104895-ORG27569
12.00Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
12.00Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
12.00Single7K15MKD0467K15-BLT1-MKD046-Na
12.00Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
12.00Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
12.00Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
12.00Single8IJDMK68928IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
12.00Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
12.00Single8J6DEP1418J6D-C3aB-EP141-Go/&β;1/&γ;2
12.00Single8JJ8Formoterol8JJ8-β2-Formoterol
12.00Single8JJLOlodaterol8JJL-β2-Olodaterol
12.00Single8JWYPubChem 1684517108JWY-A2A-PubChem 168451710
12.00Single8JWZAB9288JWZ-A2A-AB928-Na
12.00Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
12.00Single8WU1KCA8WU1-CB1-KCA-Arrestin1
12.00Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
12.00Consensusblt1_offOrthosteric Ligand7K15-BLT1-MKD046-Na
12.00Consensusblt_offOrthosteric Ligandblt1_off
12.00Consensuscb1_off_alloOrthosteric Ligand6KQI-CB1-PubMed 104895-ORG27569
12.00Consensusgpr119_onOrthosteric Ligand7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
12.00Consensusgs_bileacidOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
12.00Consensusgs_steroidOrthosteric Ligandgs_bileacid
12.00Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
12.00Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
12.00Consensusopioid_offOrthosteric Ligandkop_off mop_off nop_off dop_off
11.76Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
11.76Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
11.76Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
11.76Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
11.76Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
11.76Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
11.76Single8PWNTheophylline8PWN-A2A-Theophylline
11.76Consensusclass-c_onOther Ligandgabab_on mglu_on
11.76Consensuscrf1_onOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
11.54Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
11.54Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
11.54Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
11.54Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
11.54Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
11.54Single6IBLArformoterol6IBL-β1-Arformoterol
11.54Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
11.54Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.54Single7UM4AS26747237UM4-5-HT5A-AS2674723
11.54Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
11.54Single7XJISolabegron7XJI-β3-Solabegron-Gs/&β;1/&γ;2
11.54Single7XK2MK68927XK2-HCA2-MK6892-Gi1/&β;1/&γ;2
11.54Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/&β;1/&γ;2
11.54Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
11.54Consensus5ht5a_offOrthosteric Ligand7UM4-5-HT5A-AS2674723
11.54Consensusbileacid_onOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
11.54Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
11.54Consensusendothelin_offOrthosteric Ligandetb_off
11.54Consensusetb_offOrthosteric Ligand5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500 5X93-ETB-K-8794
11.54Consensusot_onOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
11.54Consensussteroid_onOrthosteric Ligandbileacid_on
11.11Single4UG2CGS216804UG2-A2A-CGS21680
11.11Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
11.11Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
11.11Single7VDMSubstance P7VDM-MRGPRX2-Substance P-Gi1/&β;1/&γ;2
11.11Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
11.11Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
11.11Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
11.11Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/&β;1/&γ;2
11.11Single8INRAlpha-MSH8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
11.11Single8IYHMK68928IYH-HCA2-MK6892-Go/&β;1/&γ;2
11.11Single8XZFWN5618XZF-Apelin-WN561-Gi1/&β;1/&γ;2
11.11Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
11.11Consensuslpl_offOrthosteric Ligands1p_off lpa_off
11.11Consensuslpl_onOrthosteric Ligands1p_on lpa_on
10.71Single4XT1Fractalkine4XT1-US28-Fractalkine
10.71Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
10.71Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
10.71Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
10.71Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
10.71Single8J6RMK68928J6R-HCA2-MK6892-Gi1/&β;1/&γ;2
10.71Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
10.71Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
10.53Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
10.53Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
10.53Single8EITDoconexent8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
10.53Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
10.53Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/&β;1/&γ;2
10.53Single8J6QBeta-hydroxybutyrate8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
10.34Single7SK5CXCL127SK5-ACKR3-CXCL12
10.34Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
10.26Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
10.26Consensuspth_onOrthosteric Ligandpth1_on pth2_on
10.00Single3OE9IT1t3OE9-CXCR4-IT1t
10.00Single3PBLEticlopride3PBL-D3-Eticlopride
10.00Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
10.00Single6QNOAll-trans-retinal6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
10.00Single6TP4ACT-4622066TP4-OX1-ACT-462206
10.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
10.00Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
10.00Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
10.00Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/&β;1/&γ;2
10.00Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/&β;1/&γ;2
10.00Single8EF6Morphine8EF6-μ-Morphine-Gi1/&β;1/&γ;2
10.00Single8GGCEpinephrine8GGC-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
10.00Single8GGEEpinephrine8GGE-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
10.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
10.00Consensus5ht4_onOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
10.00Consensusclass-t_onOrthosteric Ligandtaste2_on
10.00Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
10.00Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
10.00Consensusgo_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
10.00Consensusgo_proteinOrthosteric Ligandgo_chemokine
10.00Consensusgs_class-tOrthosteric Ligandgs_taste
10.00Consensusgs_tasteOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
10.00Consensusm4_on_alloOther Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
10.00Consensusox1_off_alloOrthosteric Ligand6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na 6TO7-OX1-Suvorexant-Na
10.00Consensussmo_on_alloOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
10.00Consensustaste2_onOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
9.76Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
9.76Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
9.68Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
9.68Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
9.68Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
9.68Single8IHFMK68928IHF-HCA2-MK6892-Gi1/&β;1/&γ;2
9.68Single8J6IMK68928J6I-HCA2-MK6892-Gi1/&β;1/&γ;2
9.68Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
9.52Single2X72All-trans-retinal2X72-Rhodopsin-All-trans-retinal-Gt(CT)
9.52Single4S0VSuvorexant4S0V-OX2-Suvorexant
9.52Single5WS3EMPA5WS3-OX2-EMPA
9.52Single6B73PubChem 1319551386B73-κ-PubChem 131955138
9.52Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
9.52Single6NWEOctyl Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
9.52Single6TODEMPA6TOD-OX1-EMPA-Na
9.52Single6TPJSuvorexant6TPJ-OX2-Suvorexant
9.52Single6WWZCCL206WWZ-CCR6-CCL20-Go/&β;1/&γ;2
9.52Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2
9.52Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
9.52Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
9.52Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
9.52Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
9.52Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
9.52Single7TUZ7alpha,25-dihydroxycholesterol7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
9.52Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
9.52Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2
9.52Single7XRRLemborexant7XRR-OX2-Lemborexant
9.52Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
9.52Single8DWHCompound-168DWH-MRGPRX1-Compound-16-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.52Single8EFOPZM218EFO-μ-PZM21-Gi1/&β;1/&γ;2
9.52Single8GEDEpinephrine8GED-β2-Epinephrine-Gs/&β;1/&γ;2
9.52Single8GG9Epinephrine8GG9-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
9.52Single8GGFEpinephrine8GGF-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
9.52Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2
9.52Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
9.52Single8UNLEpinephrine8UNL-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
9.52Single8UNTEpinephrine8UNT-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
9.52Single8UNUEpinephrine8UNU-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
9.52Single8UNWEpinephrine8UNW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
9.52Single8UO0Epinephrine8UO0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
9.52Single8UO1Epinephrine8UO1-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
9.52Single8UO3Epinephrine8UO3-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
9.52Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
9.52Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
9.52Consensusalpha2_offOrthosteric Ligandalpha2a_off alpha2c_off
9.52Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
9.52Consensusclass-f_offOrthosteric Ligandsmo_off
9.52Consensusgi_nucleotideOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
9.52Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
9.52Consensusmglu_onOther Ligandmglu2_on mglu4_on
9.52Consensusorexin_offOrthosteric Ligandox2_off ox1_off
9.38Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
9.38Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
9.38Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
9.38Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
9.38Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
9.38Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
9.38Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
9.09Single2YDOAdenosine2YDO-A2A-Adenosine
9.09Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
9.09Single4MBSMaraviroc4MBS-CCR5-Maraviroc
9.09Single4ZJCSB-6740424ZJC-OX1-SB-674042
9.09Single5TE3Octyl Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
9.09Single6IQLL7458706IQL-D4-L745870
9.09Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
9.09Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
9.09Single6PS4ICI 118-5516PS4-β2-ICI 118-551
9.09Single6PS5(S)-Propranolol6PS5-β2-(S)-Propranolol
9.09Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
9.09Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
9.09Single6TP3Nemorexant6TP3-OX1-Nemorexant
9.09Single6TPGEMPA6TPG-OX2-EMPA
9.09Single6TPNHTL66416TPN-OX2-HTL6641
9.09Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
9.09Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
9.09Single7D3SSecretin7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
9.09Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
9.09Single7JOZVFP7JOZ-D1-VFP-Gs/&β;1/&γ;2
9.09Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
9.09Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
9.09Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
9.09Single7T32ZM2413857T32-A2A-ZM241385
9.09Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
9.09Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
9.09Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
9.09Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
9.09Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.09Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
9.09Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
9.09Single8GDZEpinephrine8GDZ-β2-Epinephrine-Gs/&β;1/&γ;2
9.09Single8GEGEpinephrine8GEG-β2-Epinephrine-Gs/&β;1/&γ;2
9.09Single8GG3Epinephrine8GG3-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
9.09Single8GG5Epinephrine8GG5-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
9.09Single8GG8Epinephrine8GG8-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
9.09Single8GGKEpinephrine8GGK-β2-Epinephrine
9.09Single8GGLEpinephrine8GGL-β2-Epinephrine
9.09Single8GGMEpinephrine8GGM-β2-Epinephrine
9.09Single8GGPEpinephrine8GGP-β2-Epinephrine
9.09Single8GGQEpinephrine8GGQ-β2-Epinephrine
9.09Single8GGTEpinephrine8GGT-β2-Epinephrine
9.09Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2
9.09Single8GURPubChem 1048958GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2
9.09Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
9.09Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
9.09Single8JERAcipimox8JER-HCA2-Acipimox-Go/&β;1/&γ;2
9.09Single8JIMMMF8JIM-HCA2-MMF-Gi1/&β;1/&γ;2
9.09Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
9.09Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
9.09Single8K2WAMG4878K2W-CXCR3-AMG487
9.09Single8K5CAcipimox8K5C-HCA2-Acipimox
9.09Single8UNREpinephrine8UNR-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
9.09Single8UNSEpinephrine8UNS-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
9.09Single8UNZEpinephrine8UNZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
9.09Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
9.09Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.09Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
9.09Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
9.09Consensushca_onOrthosteric Ligandhca2_on hca3_on
9.09Consensushcar_onOrthosteric Ligandhca_on
9.09Consensusm1_off_alloOther Ligand6WJC-M1-Atropine-Muscarinic toxin 7
9.09Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
9.09Consensusox1_offOrthosteric Ligand6TOT-OX1-Lemborexant 6TP4-OX1-ACT-462206 6TP6-OX1-Filorexant 6V9S-OX1-GTPL11403 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ7-OX1-SB-334867 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant
9.09Consensusox2_offOrthosteric Ligand6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant
8.82Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
8.82Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
8.82Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
8.82Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
8.82Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
8.82Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
8.82Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
8.70Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
8.70Single2Y02Carmoterol2Y02-β1-Carmoterol
8.70Single2Y04Salbutamol2Y04-β1-Salbutamol
8.70Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
8.70Single3NY8ICI 118-5513NY8-β2-ICI 118-551
8.70Single3NYA(S)-Alprenolol3NYA-β2-(S)-Alprenolol
8.70Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
8.70Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
8.70Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
8.70Single4GBR(S)-Carazolol4GBR-β2-(S)-Carazolol
8.70Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
8.70Single4X1HNonyl Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
8.70Single5DHGPubChem 250014125DHG-NOP-PubChem 25001412
8.70Single5JQH(S)-Carazolol5JQH-β2-(S)-Carazolol
8.70Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
8.70Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
8.70Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
8.70Single6PRZ(S)-Alprenolol6PRZ-β2-(S)-Alprenolol
8.70Single6PS0(S)-Carazolol6PS0-β2-(S)-Carazolol
8.70Single6PS2(S)-Alprenolol6PS2-β2-(S)-Alprenolol
8.70Single6TOTLemborexant6TOT-OX1-Lemborexant
8.70Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
8.70Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
8.70Single7BU7BI1671077BU7-β1-BI167107
8.70Single7CFMP3957CFM-GPBA-P395-Gs/&β;1/&γ;2
8.70Single7CRHSKF839597CRH-D1-SKF83959-Gs/&β;1/&γ;2
8.70Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
8.70Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
8.70Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
8.70Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
8.70Single7LJCPubChem 867641037LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
8.70Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
8.70Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
8.70Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/&β;1/&γ;2
8.70Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2
8.70Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
8.70Single7V3ZPubMed 1048957V3Z-CB1-PubMed 104895
8.70Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
8.70Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
8.70Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
8.70Single8EFQDamgo8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
8.70Single8EJCTAK-8758EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
8.70Single8EJKTAK-8758EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
8.70Single8GE3Epinephrine8GE3-β2-Epinephrine-Gs/&β;1/&γ;2
8.70Single8GEBEpinephrine8GEB-β2-Epinephrine-Gs/&β;1/&γ;2
8.70Single8GEEEpinephrine8GEE-β2-Epinephrine-Gs/&β;1/&γ;2
8.70Single8GFWEpinephrine8GFW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
8.70Single8GFXEpinephrine8GFX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
8.70Single8GFYEpinephrine8GFY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
8.70Single8GFZEpinephrine8GFZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
8.70Single8GG0Epinephrine8GG0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
8.70Single8GG1Epinephrine8GG1-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
8.70Single8GG2Epinephrine8GG2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
8.70Single8GG6Epinephrine8GG6-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
8.70Single8GGJEpinephrine8GGJ-β2-Epinephrine
8.70Single8GGNEpinephrine8GGN-β2-Epinephrine
8.70Single8GGOEpinephrine8GGO-β2-Epinephrine
8.70Single8GGUEpinephrine8GGU-β2-Epinephrine
8.70Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/&β;1/&γ;2
8.70Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/&β;1/&γ;2
8.70Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
8.70Single8JJOAlprenolol8JJO-β2-Alprenolol
8.70Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
8.70Single8K5DGSK2560738K5D-HCA2-GSK256073
8.70Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
8.70Single8UNNEpinephrine8UNN-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
8.70Single8UNPEpinephrine8UNP-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
8.70Consensus5ht1a_onOrthosteric Ligand8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
8.70Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
8.70Consensusadrenergic_onOrthosteric Ligandbeta_on alpha_on
8.70Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
8.70Consensuscb1_on_alloOrthosteric Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
8.70Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
8.70Consensusdopamine_onOrthosteric Ligandd3_on d2_on d5_on d1_on
8.70Consensusgi_5htOrthosteric Ligand7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
8.70Consensusgi_hcaOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
8.70Consensusgi_hcarOrthosteric Ligandgi_hca
8.70Consensushca2_onOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
8.70Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
8.70Consensussmo_offOrthosteric Ligand5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
8.57Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
8.57Single6LMLGlucagon6LML-Glucagon-Glucagon
8.57Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
8.57Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
8.57Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
8.33Single2RH1(S)-Carazolol2RH1-β2-(S)-Carazolol
8.33Single2Y03Isoprenaline2Y03-β1-Isoprenaline
8.33Single2YCW(S)-Carazolol2YCW-β1-(S)-Carazolol
8.33Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
8.33Single5C1MBU725C1M-μ-BU72
8.33Single5D6L(S)-Carazolol5D6L-β2-(S)-Carazolol
8.33Single5TVNLSD5TVN-5-HT2B-LSD
8.33Single5XPRBosentan5XPR-ETB-Bosentan
8.33Single6E67BI1671076E67-β2-BI167107-Gs (fused)
8.33Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
8.33Single6LUQHaloperidol6LUQ-D2-Haloperidol
8.33Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
8.33Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
8.33Single6PS3(S)-Carvedilol6PS3-β2-(S)-Carvedilol
8.33Single6PS6Timolol6PS6-β2-Timolol
8.33Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
8.33Single6TP6Filorexant6TP6-OX1-Filorexant
8.33Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
8.33Single7BVQ(S)-Carazolol7BVQ-β1-(S)-Carazolol
8.33Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
8.33Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
8.33Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
8.33Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
8.33Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2
8.33Single7WC6LSD7WC6-5-HT2A-LSD
8.33Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
8.33Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
8.33Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
8.33Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
8.33Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
8.33Consensusadrenergic_offOrthosteric Ligandbeta_off alpha_off
8.33Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
8.33Consensusamine_offOrthosteric Ligandadrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
8.33Consensusbeta2_offOrthosteric Ligand6PS2-β2-(S)-Alprenolol 6PS3-β2-(S)-Carvedilol 6PS5-β2-(S)-Propranolol 6PS6-β2-Timolol 2RH1-β2-(S)-Carazolol 6PS4-β2-ICI 118-551 3NY9-β2-PubChem 913103
8.33Consensusbeta2_onOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
8.33Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
8.33Consensuscb2_onOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
8.33Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
8.33Consensusgi_adrenergicOrthosteric Ligand7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
8.33Consensusgs_crfOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
8.11Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
8.11Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
8.11Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
8.11Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
8.11Consensusglp_onOrthosteric Ligandglp1_on glp2_on
8.00Single2YDVNECA2YDV-A2A-NECA
8.00Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
8.00Single4DJHJDTic4DJH-κ-JDTic
8.00Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
8.00Single4UHRCGS216804UHR-A2A-CGS21680
8.00Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
8.00Single5D5A(S)-Carazolol5D5A-β2-(S)-Carazolol
8.00Single5D5B(S)-Carazolol5D5B-β2-(S)-Carazolol
8.00Single5G53NECA5G53-A2A-NECA-Gs
8.00Single5V54Methiothepin5V54-5-HT1B-Methiothepin
8.00Single5V56TC1145V56-SMO-TC114
8.00Single5XR8AM8415XR8-CB1-AM841
8.00Single6TQ7SB-3348676TQ7-OX1-SB-334867
8.00Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
8.00Single6WGTLSD6WGT-5-HT2A-LSD
8.00Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2
8.00Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
8.00Single7EW7PubChem 40774607EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
8.00Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
8.00Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
8.00Single7W6PW967W6P-α2a-W96-Go/&β;1/&γ;2
8.00Single7W7EW587W7E-α2a-W58-Go/&β;1/&γ;2
8.00Single7XTQR3997XTQ-GPBA-R399-Gs/&β;1/&γ;2
8.00Single8EFLSR170188EFL-μ-SR17018-Gi1/&β;1/&γ;2
8.00Single8GUSHU-3088GUS-CB2-HU-308-Gi1/&β;1/&γ;2
8.00Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2
8.00Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2
8.00Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/&β;1/&γ;2
8.00Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
8.00Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/&β;1/&γ;2
8.00Single8JD0J9R8JD0-mGlu2; mGlu3-Glutamate-J9R
8.00Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
8.00Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
8.00Consensus5ht1_offOrthosteric Ligand5ht1b_off
8.00Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
8.00Consensus5ht_offOrthosteric Ligand5ht2_off 5ht5_off 5ht1_off
8.00Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCZ-β1-Iodocyanopindolol
8.00Consensusdopamine_offOrthosteric Ligandd3_off d2_off d4_off
8.00Consensusgi_amineOrthosteric Ligandgi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
8.00Consensusgi_muscarinicOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
8.00Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
8.00Consensusmglu2_onOther Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
8.00Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
8.00Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
7.89Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
7.89Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
7.89Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
7.89Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
7.69Single3D4STimolol Maleate3D4S-β2-Timolol Maleate
7.69Single4AMIBucindolol4AMI-β1-Bucindolol
7.69Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
7.69Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
7.69Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
7.69Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
7.69Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
7.69Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
7.69Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/&β;1/&γ;2
7.69Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/&β;1/&γ;2
7.69Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
7.69Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
7.69Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
7.69Single7WCNAR2314537WCN-GPR119-AR231453-Gs/&β;1/&γ;2
7.69Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
7.69Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
7.69Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
7.69Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/&β;1/&γ;2
7.69Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
7.69Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg3_on
7.69Consensusat2_offOrthosteric Ligand7JNI-AT2-Olodanrigan
7.69Consensuscannabinoid_onOrthosteric Ligandcb1_on cb2_on
7.69Consensuscb1_onOrthosteric Ligand8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
7.69Consensusclass-b2_onOrthosteric Ligandadgrg_on
7.69Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
7.69Consensusgi_cannabinoidOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
7.69Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
7.69Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
7.69Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
7.69Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
7.50Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
7.41Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
7.41Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
7.41Single6H7LDobutamine6H7L-β1-Dobutamine
7.41Single6K1QIRL25006K1Q-ETB-IRL2500
7.41Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/&β;1/&γ;2
7.41Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
7.41Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
7.41Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
7.41Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
7.41Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/&β;1/&γ;2
7.41Single7XZ6APD6687XZ6-GPR119-APD668-Gs/&β;1/&γ;2
7.41Single8E9YPubChem 4466038E9Y-M3-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.41Single8GAGYVF8GAG-CB1-YVF-Gi1/&β;1/&γ;2
7.41Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
7.41Consensusbeta1_off_alloOrthosteric Ligand4BVN-β1-Cyanopindolol-Na
7.41Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
7.14Single5ZTYAM102575ZTY-CB2-AM10257
7.14Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
7.14Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
7.14Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
7.14Consensusclass-d_offOrthosteric Ligandste2_off
7.14Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
7.14Consensusgs_adgrOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
7.14Consensusgs_class-b2Orthosteric Ligandgs_adgr
6.98Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
6.90Single4AMJ(S)-Carvedilol4AMJ-β1-(S)-Carvedilol
6.90Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
6.90Single7QA8Peptide7QA8-STE2-Peptide
6.90Single7QA8Peptide7QA8-STE2-Peptide
6.90Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
6.90Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
6.90Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
6.90Consensusclass-d_offOrthosteric Ligandste2_off
6.67Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
6.67Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
6.67Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
6.67Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
6.67Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
6.45Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
6.25Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
6.25Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
6.25Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
6.25Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
6.25Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
6.25Consensusclass-d_onOrthosteric Ligandste2_on
6.25Consensusgi_class-dOrthosteric Ligandgi_ste
6.25Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
6.25Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
6.06Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
6.06Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
6.06Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
5.88Single6FJ3PTH6FJ3-PTH1-PTH
5.88Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/&β;1/&γ;2
5.88Single6W25Ca6W25-MC4-SHU9119-Ca
5.88Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
5.88Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
5.88Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
5.88Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
5.88Consensusclass-d_onOrthosteric Ligandste2_on
5.88Consensusghrh_onOrthosteric Ligand7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
5.88Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
5.71Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
5.71Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
5.71Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
5.71Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
5.71Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
5.71Consensusgi_class-dOrthosteric Ligandgi_ste
5.71Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
5.71Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
5.71Consensusgo_class-b1Orthosteric Ligandgo_crf
5.71Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
5.56Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
5.56Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
5.56Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
5.56Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
5.56Single8GEJEpinephrine8GEJ-β2-Epinephrine-Gs/&β;1/&γ;2
5.56Single8HSCFab0468HSC-GPR20-Fab046-Gi1/&β;1/&γ;2
5.56Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
5.56Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
5.56Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
5.56Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
5.56Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
5.41Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
5.41Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
5.41Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
5.41Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
5.26Single6OY9All-trans-retinal6OY9-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
5.26Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.26Single7MTBAll-trans-retinal7MTB-Rhodopsin-All-trans-retinal-GRK1
5.26Single7Y14Beta-alanine7Y14-MRGPRD-Beta-alanine
5.26Consensushca2_on_alloOrthosteric Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
5.26Consensussensory_onOrthosteric Ligandopsin_on
5.13Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
5.13Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
5.00Single3OE6IT1t3OE6-CXCR4-IT1t
5.00Single3OE8IT1t3OE8-CXCR4-IT1t
5.00Single5WKTOctyl Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
5.00Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
5.00Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
5.00Single6FUFAll-trans-retinal6FUF-Rhodopsin-All-trans-retinal-Go/&β;1/&γ;2
5.00Single6ME5Agomelatine6ME5-MT1-Agomelatine
5.00Single6ME9Ramelteon6ME9-MT2-Ramelteon
5.00Single7MT9All-trans-retinal7MT9-Rhodopsin-All-trans-retinal-GRK1
5.00Single7MTAAll-trans-retinal7MTA-Rhodopsin-All-trans-retinal-GRK1
5.00Single7WC5Psilocin7WC5-5-HT2A-Psilocin
5.00Single7Y12Beta-alanine7Y12-MRGPRD-Beta-alanine-Gi1/&β;1/&γ;2
5.00Single8F76-8F76-OR51E2-Gs/&β;1/&γ;2
5.00Single8GGREpinephrine8GGR-β2-Epinephrine
5.00Single8GGZEpinephrine8GGZ-β2-Epinephrine
5.00Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
5.00Consensusgip_on_alloOther Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
5.00Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
5.00Consensusopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
5.00Consensussmo_off_alloOrthosteric Ligand6D32-SMO-Cyclopamine-Cyclopamine
4.88Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
4.76Single3AYMAll-trans-retinal3AYM-Rhodopsin-All-trans-retinal
4.76Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
4.76Single4O9RCyclopamine4O9R-SMO-Cyclopamine
4.76Single5L7IVismodegib5L7I-SMO-Vismodegib
4.76Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
4.76Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
4.76Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
4.76Single7SRQLSD7SRQ-5-HT2B-LSD
4.76Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2
4.76Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2
4.76Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
4.76Single8GEIEpinephrine8GEI-β2-Epinephrine-Gs/&β;1/&γ;2
4.76Single8GGSEpinephrine8GGS-β2-Epinephrine
4.76Single8GGYEpinephrine8GGY-β2-Epinephrine
4.76Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2
4.76Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2
4.76Single8IJANiacin8IJA-HCA2-Niacin-Gi1/&β;1/&γ;2
4.76Single8IY9Niacin8IY9-HCA2-Niacin-Go/&β;1/&γ;2
4.76Single8K5BNiacin8K5B-HCA2-Niacin
4.76Single8UNVEpinephrine8UNV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
4.76Single8UNXEpinephrine8UNX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
4.76Single8X2K5YM8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
4.76Consensusmt1_onOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
4.76Consensusmt2_onOrthosteric Ligand7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
4.55Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
4.55Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
4.55Single3ODUIT1t3ODU-CXCR4-IT1t
4.55Single4QINSAG1.54QIN-SMO-SAG1.5
4.55Single5DHHSB-6121115DHH-NOP-SB-612111
4.55Single5ZKQABT-4915ZKQ-PAF-ABT-491
4.55Single6AKXA4R6AKX-CCR5-A4R
4.55Single6AKYMaraviroc6AKY-CCR5-Maraviroc
4.55Single6KUXRS-799486KUX-α2a-RS-79948
4.55Single6ME2Ramelteon6ME2-MT1-Ramelteon
4.55Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
4.55Single6OBA(S)-Alprenolol6OBA-β2-(S)-Alprenolol-GTPL11074
4.55Single6OYAAll-trans-retinal6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
4.55Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
4.55Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2
4.55Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
4.55Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/&β;1/&γ;2
4.55Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;1
4.55Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.55Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
4.55Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
4.55Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
4.55Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
4.55Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
4.55Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2
4.55Single8GEAEpinephrine8GEA-β2-Epinephrine-Gs/&β;1/&γ;2
4.55Single8GECEpinephrine8GEC-β2-Epinephrine-Gs/&β;1/&γ;2
4.55Single8GEFEpinephrine8GEF-β2-Epinephrine-Gs/&β;1/&γ;2
4.55Single8GG7Epinephrine8GG7-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
4.55Single8GGAEpinephrine8GGA-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
4.55Single8GGVEpinephrine8GGV-β2-Epinephrine
4.55Single8GGWEpinephrine8GGW-β2-Epinephrine
4.55Single8GGXEpinephrine8GGX-β2-Epinephrine
4.55Single8GH0Epinephrine8GH0-β2-Epinephrine
4.55Single8IHKAcifran8IHK-HCA3-Acifran
4.55Single8IW4Spermidine8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2
4.55Single8IWESpermidine8IWE-TAAR9-Spermidine
4.55Single8UNOEpinephrine8UNO-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
4.55Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
4.55Consensusalpha2a_offOrthosteric Ligand6KUX-α2a-RS-79948
4.55Consensusbeta2_off_alloOrthosteric Ligand6OBA-β2-(S)-Alprenolol-GTPL11074
4.55Consensusgs_5htOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2 7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2 7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.55Consensusgt_class-aOrthosteric Ligandgt_opsin
4.55Consensusgt_opsinOrthosteric Ligandgt_sensory
4.55Consensusgt_sensoryOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
4.55Consensusmelatonin_onOrthosteric Ligandmt1_on mt2_on
4.44Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
4.35Single3RZECidoxepin3RZE-H1-Cidoxepin
4.35Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
4.35Single6A94Zotepine6A94-5-HT2A-Zotepine
4.35Single6DS0Ly2660976DS0-5-HT2B-Ly266097
4.35Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
4.35Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
4.35Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
4.35Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
4.35Single6VI4JDTic6VI4-κ-JDTic
4.35Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
4.35Single6ZG9GSK10347026ZG9-M1-GSK1034702
4.35Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/&β;1/&γ;2
4.35Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
4.35Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
4.35Single7CMVPD1289077CMV-D3-PD128907-Gi1/&β;1/&γ;2
4.35Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
4.35Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
4.35Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2
4.35Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
4.35Single7F0TDopamine7F0T-D1-Dopamine-Gs/&β;1/&γ;2
4.35Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/&β;1/&γ;2
4.35Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.35Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
4.35Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
4.35Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
4.35Single8GE1Epinephrine8GE1-β2-Epinephrine-Gs/&β;1/&γ;2
4.35Single8GE4Epinephrine8GE4-β2-Epinephrine-Gs/&β;1/&γ;2
4.35Single8GE6Epinephrine8GE6-β2-Epinephrine-Gs/&β;1/&γ;2
4.35Single8GE7Epinephrine8GE7-β2-Epinephrine-Gs/&β;1/&γ;2
4.35Single8GE8Epinephrine8GE8-β2-Epinephrine-Gs/&β;1/&γ;2
4.35Single8GE9Epinephrine8GE9-β2-Epinephrine-Gs/&β;1/&γ;2
4.35Single8GFVEpinephrine8GFV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
4.35Single8GG4Epinephrine8GG4-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
4.35Single8GGIEpinephrine8GGI-β2-Epinephrine
4.35Single8JD6N-(3-chlorophenyl)pyridine-2-carboxamide8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
4.35Single8JHNMMF8JHN-HCA2-MMF-Go/&β;1/&γ;2
4.35Single8JLNT1AM8JLN-TA1-T1AM-Gs/&β;1/&γ;2
4.35Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2
4.35Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.35Single8UHBRO52563908UHB-TA1-RO5256390-Gs/&β;1/&γ;2
4.35Single8UNQEpinephrine8UNQ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
4.35Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/&β;1/&γ;2
4.35Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
4.35Consensus5ht5_onOrthosteric Ligand5ht5a_on
4.35Consensus5ht5a_onOrthosteric Ligand7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
4.35Consensusalpha2b_onOrthosteric Ligand6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
4.35Consensusd1_on_alloOrthosteric Ligand7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
4.35Consensusd3_onOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
4.35Consensusgi_class-fOrthosteric Ligandgi_frizzled
4.35Consensusgi_frizzledOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
4.35Consensusgi_melatoninOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
4.35Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
4.35Consensuss1p_offOrthosteric Ligands1p1_off
4.17Single2Y01Dobutamine2Y01-β1-Dobutamine
4.17Single4QKXPubChem 762106284QKX-β2-PubChem 76210628
4.17Single5TGZAM65385TGZ-CB1-AM6538
4.17Single6DRXLisuride6DRX-5-HT2B-Lisuride
4.17Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
4.17Single6GPSMK08126GPS-CCR2-MK0812
4.17Single6H7MSalbutamol6H7M-β1-Salbutamol
4.17Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
4.17Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2
4.17Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/&β;1/&γ;2
4.17Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
4.17Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.17Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
4.17Single7F83PF-051904577F83-Ghrelin-PF-05190457
4.17Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
4.17Single7SCGFH2107SCG-μ-FH210-Gi1/&β;1/&γ;2
4.17Single7T2GMitragynine pseudoindoxyl7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
4.17Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/&β;1/&γ;2
4.17Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
4.17Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
4.17Single7WC7Lisuride7WC7-5-HT2A-Lisuride
4.17Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
4.17Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
4.17Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2
4.17Single8JLZST19368JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
4.17Single8UO4Epinephrine8UO4-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
4.17Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
4.17Single8X63Mepyramine8X63-H1-Mepyramine
4.17Single8X64Desloratadine8X64-H1-Desloratadine
4.17Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
4.17Consensusalpha2_onOrthosteric Ligandalpha2a_on alpha2b_on
4.17Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
4.17Consensusamine_onOrthosteric Ligandadrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on
4.17Consensushca3_onOrthosteric Ligand8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
4.17Consensushcar_offOrthosteric Ligandsuccinate_off
4.17Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
4.17Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
4.00Single2Y00Dobutamine2Y00-β1-Dobutamine
4.00Single4JKVTaladegib (LY2940680)4JKV-SMO-Taladegib (LY2940680)
4.00Single4WW3All-trans-retinal4WW3-Rhodopsin-All-trans-retinal
4.00Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
4.00Single5WIUNemonapride5WIU-D4-Nemonapride
4.00Single5WIVNemonapride5WIV-D4-Nemonapride-Na
4.00Single6GPXMK08126GPX-CCR2-MK0812
4.00Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
4.00Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
4.00Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
4.00Single7C4SS1P7C4S-S1P3-S1P
4.00Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
4.00Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
4.00Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
4.00Single7YXAONO-54306087YXA-S1P5-ONO-5430608
4.00Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
4.00Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2
4.00Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide 6DRX-5-HT2B-Lisuride
4.00Consensusalpha2a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
4.00Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
4.00Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
4.00Consensusccr2_off_alloOther Ligand5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
4.00Consensusd4_offOrthosteric Ligand5WIU-D4-Nemonapride
4.00Consensusd4_off_alloOrthosteric Ligand5WIV-D4-Nemonapride-Na
4.00Consensusgo_amineOrthosteric Ligandgo_adrenergic go_muscarinic go_5ht
4.00Consensusgs_adrenergicOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJI-β3-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
4.00Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
3.85Single5V57TC1145V57-SMO-TC114
3.85Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
3.85Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2
3.85Single7EPENAM5637EPE-mGlu-NAM563
3.85Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2
3.85Single7P2L4YI7P2L-mGlu5-4YI
3.85Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2
3.85Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
3.85Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
3.85Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
3.85Single8JXVClozapine8JXV-H4-Clozapine-Gi1/&β;1/&γ;2
3.85Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/&β;1/&γ;2
3.85Consensusangiotensin_offOrthosteric Ligandat1_off at2_off
3.85Consensusgo_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
3.85Consensush1_offOrthosteric Ligand3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole 8X63-H1-Mepyramine 8X64-H1-Desloratadine
3.85Consensushistamine_offOrthosteric Ligandh1_off
3.85Consensuss1p2_onOrthosteric Ligand7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
3.70Single4N4WSANT-14N4W-SMO-SANT-1
3.70Single5X33BIIL2605X33-BLT1-BIIL260
3.70Single6A93Risperidone6A93-5-HT2A-Risperidone
3.70Single6CM4Risperidone6CM4-D2-Risperidone
3.70Single6H7N(S)-Xamoterol6H7N-β1-(S)-Xamoterol
3.70Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
3.70Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
3.70Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
3.70Single6ZG4HTL00099366ZG4-M1-HTL0009936
3.70Single7DFPSpiperone7DFP-D2-Spiperone
3.70Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
3.70Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
3.70Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.70Consensusbeta1_onOrthosteric Ligand7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
3.70Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
3.70Consensusgi_class-fOther Ligandgi_frizzled
3.70Consensusgi_frizzledOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
3.70Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
3.57Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
3.57Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
3.57Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
3.57Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
3.57Consensusadgrg2_onOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
3.57Consensusgs_lipidOrthosteric Ligandgs_ffa gs_prostanoid
3.45Single5EE7MK08935EE7-Glucagon-MK0893
3.45Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
3.45Single8X5YAstemizole8X5Y-H1-Astemizole
3.45Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
3.33Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
3.33Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
3.23Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
3.03Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
3.03Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
2.94Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
2.94Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
2.94Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
2.78Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
2.78Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
2.70Consensuscalcitonin_onOrthosteric Ligandct_on ctlike_on
2.63Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
2.63Single7TYLAmylin7TYL-CT-Amylin-Gs/&β;1/&γ;2
2.63Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
2.63Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/&β;1/&γ;2; RAMP2
2.56Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
2.50Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
2.50Single8F0KPramlintide analogue san3858F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.44Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
2.33Single8F2APramlintide analogue san3858F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.22Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
2.17Single8F2BPramlintide analogue san458F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
2.17Consensusgs_ctOrthosteric Ligand7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.08Single8F0JPramlintide analogue san458F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2

Consensus Members
Id Members
nts1_off 6Z4Q-NTS1-SR142948A
6Z4S-NTS1-SR48692
Net Summary
Imin 2.92
Number of Linked Nodes 252
Number of Links 310
Number of Hubs 47
Number of Links mediated by Hubs 174
Number of Communities 6
Number of Nodes involved in Communities 65
Number of Links involved in Communities 106
Path Summary
Number Of Nodes in MetaPath 77
Number Of Links MetaPath 76
Number of Shortest Paths 138376
Length Of Smallest Path 3
Average Path Length 15.6186
Length of Longest Path 28
Minimum Path Strength 0.6675
Average Path Strength 6.0746
Maximum Path Strength 16.2825
Minimum Path Correlation 0.7
Average Path Correlation 0.91155
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 5
Average % Of Corr. Nodes 34.4203
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 48.9925
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following consensuses:
IdComponents
peptide_offopioid_off
angiotensin_off
bombesin_off
cck_off
endothelin_off
ghrelin_off
npy_off
nts_off
orexin_off
vasopressin-ot_off
tachykinin_off
sst_off



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