Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
11x35 2.10125406
21x57 2.83375406
32x38 4.3025496
42x42 3.80417697
52x46 4.31375409
62x50 4.58875409
72x51 5.28125408
82x60 6.04426
92x64 6.249525
10E1x50 7.87628
11E1x52 7.228506
123x29 6.17524
133x30 4.94875426
143x34 4.416524
153x36 5.56375427
163x37 4.32167626
173x49 8.62498
183x50 6.854509
193x51 7.61375408
20I2x57 7.56375496
214x38 3.71375407
224x50 4.90125409
234x56 5.0525404
244x61 12.1525424
254x64 6.90643724
264x65 11.2962425
27E2 11.06181123
28E2x52 6.085524
295x36 6.866524
305x47 5.9995198
315x54 4.171254108
325x57 3.72875407
335x58 6.423336109
346x31 3.30625404
356x40 3.255408
366x44 4.6295109
376x48 5.12375409
386x51 4.14125407
39E3 7.37857723
407x34 9.048523
417x38 10.6337425
427x42 5.69929727
437x49 4.98409
447x53 5.6175409
458x50 6.027508
46Lig 9.004711720
47G.HN.33 2.67125405
48G.S1.06 5.408754148
49G.H1.01 4.5515149
50G.S3.03 7.1185118
51G.S3.04 9.47875417
52G.S3.05 3.81408
53G.S3.06 9.31625417
54G.H2.03 6.59125419
55G.H2.06 6.19167619
56G.H2.07 5.46417619
57G.h2s4.01 8.717509
58G.S4.07 6.134218
59G.s4h3.04 4.339508
60G.H3.06 5.36375406
61G.H3.09 4.05917649
62G.H3.17 12.9562415
63G.S5.05 4.2035139
64G.S5.06 3.941548
65G.S5.07 3.979509
66G.s5hg.01 6.27754219
67G.HG.01 7.67875446
68G.hgh4.01 5.28875406
69G.hgh4.02 5.143754168
70G.hgh4.04 3.9415166
71G.hgh4.08 5.47875406
72G.hgh4.16 3.88625441
73G.H4.07 6.149545
74G.H4.08 5.078543
75G.H4.10 8.9475167
76G.H4.12 5.9175404
77G.H4.14 6.928754165
78G.H4.15 7.715448
79G.h4s6.12 5.9225402
80G.S6.02 8.05125408
81G.S6.05 9.23375445
82G.s6h5.01 6.3854139
83G.s6h5.05 6.9455139
84G.H5.03 6.673754139
85G.H5.05 6.254115
86G.H5.06 5.53754134
87G.H5.08 5.218336118
88G.H5.23 9.605594
89b.1x2 4.433501
90b.1x14 3.2425404
91b.lh12x2 6.84238
92b.h2x1 5.2405
93b.h2x5 3.54405
94b.lhb1x6 3.386676153
95b.l1x1 4.75375407
96b.l1x3 8.786129
97b.l1x6 9.519519
98b.b2x1 7.548518
99b.b2x3 4.25456
100b.b2x5 7.80583657
101b.l3x2 6.6025129
102b.b4x2 6.63625408
103b.b4x5 5.0054207
104b.b4x6 11.0325129
105b.l4x2 10.2925454
106b.b5x2 4.43125407
107b.b5x3 5.789509
108b.b5x5 5.2654205
109b.b5x7 5.775407
110b.l5x1 4.668754248
111b.l5x5 9.932519
112b.b6x1 4.957519
113b.b6x5 4.07875406
114b.b7x1 5.31625404
115b.b7x4 3.358754248
116b.b8x4 5.835406
117b.l9x3 6.84333619
118b.l9x6 5.45857718
119b.b10x5 4.20625409
120b.l10x1 5.20375403
121b.b11x2 4.565417
122b.b11x4 4.79375419
123b.l11x1 4.01419
124b.l11x2 7.14375419
125b.b12x6 10.583518
126b.b13x7 6.389567
127b.l13x3 8.199569
128b.l13x6 6.7475419
129b.l13x7 3.71469
130b.b14x3 5.46125465
131b.b15x1 6.4475469
132b.b15x2 4.274536
133b.b15x3 3.94875469
134b.l15x1 5.0325417
135b.l15x2 5.07125409
136b.b16x4 11.4963466
137b.b16x6 8.49917668
138b.b16x7 5.526254179
139b.b17x7 9.31625438
140b.l17x3 8.39917639
141b.l17x6 7.4975419
142b.l17x7 4.0925437
143b.b18x3 3.525538
144b.b18x5 3.882535
145b.l18x1 5.7925886
146b.l18x2 5.4875487
147b.b19x2 6.22667636
148b.b19x4 6.45438
149b.l19x1 6.30625419
150b.l19x2 5.65625409
151b.b20x4 9.82625438
152b.b20x6 7.03083636
153b.l20x2 6.6025409
154b.b21x1 8.495537
155b.b21x2 3.52406
156b.b21x7 5.32333605
157b.b22x5 6.30333687
158b.l22x5 6.816676159
159b.b23x6 6.38083617
160b.l23x1 6.885416
161b.b24x4 7.48125416
162b.b24x6 7.57418
163b.b24x7 7.75254159
164b.l24x2 5.173754156
165b.l25x3 8.551579
166b.l25x6 8.62714718
167b.b26x3 4.2725406
168b.b27x3 5.99375478
169b.l28x1 9.73619
170b.b28x4 6.01083676
171b.b28x6 8.68579
172g.l1x4 4.094538
173g.h2x11 7.48125486
174g.h2x15 3.945406
175g.ctx3 4.97083609
176g.ctx6 2.85754156
177g.ctx14 4.481559
178g.ctx15 6.26625459
179g.ctx16 5.81071758
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
16x48 7x45 36.04166.78YesNo099
27x45 7x49 36.556810.9NoYes099
32x51 7x49 12.8332.745YesYes089
41x50 2x51 12.092612.355NoYes098
51x50 7x50 10.38667.33NoNo099
61x53 7x50 10.04451.77NoNo099
77x49 7x53 50.14542.91YesYes099
83x50 7x53 54.46036.175YesYes099
96x51 7x34 20.04113.385YesYes073
106x48 6x51 22.52014.23YesYes097
113x50 G.H5.25 65.96076.68YesNo098
126x33 G.H5.25 66.21715.96NoNo078
136x33 G.H5.20 85.56152.235NoNo078
14G.H5.17 G.H5.20 85.81722.66NoNo058
15G.H5.13 G.H5.17 87.59933.92NoNo085
16G.H5.13 G.S6.02 87.85269.77NoYes088
17G.H5.10 G.S6.02 88.863310.345NoYes078
18G.H5.10 G.S5.03 44.35979.1NoNo079
19G.S5.03 G.S5.05 44.57163.14NoYes099
20G.H5.10 G.S6.04 44.755311.98NoNo079
21G.S5.05 G.S6.04 44.42363.395YesNo099
22G.S5.05 G.s6h5.01 86.37585.835YesYes1399
23G.S5.07 G.s6h5.01 88.0255.85YesYes099
24G.S5.07 G.s5hg.01 92.61964.2YesYes099
25G.S4.07 G.s5hg.01 92.549911.065YesYes2189
26G.S4.07 G.s4h3.03 93.05011.995YesNo088
27G.s4h3.03 G.s4h3.15 93.20933.365NoNo089
28G.hgh4.01 G.s4h3.15 93.24744.07YesNo069
29G.hgh4.01 G.s4h3.04 93.47534.965YesYes068
30G.HG.04 G.s4h3.04 90.51572.93NoYes088
31G.HG.04 G.s4h3.01 90.54155.255NoNo086
32G.S5.06 G.s4h3.01 88.05724.505YesNo486
33G.S5.04 G.S5.06 93.89924.15NoYes498
34G.H3.09 G.S5.04 93.46113.655YesNo499
35G.H3.09 G.S4.04 99.98644.285YesNo099
36G.H3.08 G.S4.04 99.99114.775NoNo089
37G.H2.04 G.H3.08 1005.36NoNo098
38G.H2.04 G.H2.07 99.20846.5NoYes099
39G.H2.07 G.h2s4.01 41.58063.51YesYes099
40G.h2s4.01 b.l5x5 15.072815.035YesYes099
41G.S3.06 b.l5x5 18.500217.54YesYes179
42G.S1.03 G.S3.06 16.35785.34NoYes097
43G.S1.03 G.hns1.01 16.12027.715NoNo094
44G.hns1.01 b.l1x4 15.8952.93NoNo046
45b.l1x4 b.l3x2 15.52314.75NoYes069
465x58 6x37 15.80088.46YesNo097
47G.H2.10 G.h2s4.01 26.42662.795NoYes089
48G.H2.10 b.b2x1 26.32174.03NoYes188
49b.b2x1 b.l28x1 60.672211.575YesYes189
50b.b26x1 b.l28x1 16.98016.175NoYes099
51b.b26x1 b.b26x2 16.68453.44NoNo097
52b.b26x2 b.b2x3 16.11134.05NoYes076
53b.b2x3 b.b2x5 15.24684.075YesYes567
54G.H2.07 b.l9x6 63.14682.89YesYes198
55b.b6x1 b.l9x6 37.46016.585YesYes198
56b.b2x1 b.b6x1 34.53467.185YesYes189
57b.l11x1 b.l9x6 13.87344.35YesYes198
58b.b11x6 b.l11x1 13.09843.71NoYes199
59b.b11x6 b.l9x3 11.993714.645NoYes199
60G.H2.06 b.l9x6 36.88954.775YesYes198
61G.H2.06 b.l19x1 35.85872.765YesYes199
62b.l25x6 b.l28x1 44.719615.99YesYes189
63b.l23x1 b.l25x6 27.498813.1YesYes168
64b.l17x5 b.l19x1 35.91833.68NoYes069
65b.l17x5 b.l19x2 35.75245.15NoYes069
66b.b19x6 b.l19x2 35.0867.36NoYes099
67b.b19x6 b.l17x3 34.91869.765NoYes099
68b.b20x6 b.l17x3 30.15144.53YesYes369
69b.b17x7 b.b20x6 23.48726.43YesYes386
70b.b17x7 b.b21x1 23.75728.36YesYes387
71b.l21x7 b.l23x1 26.92744.665NoYes156
72b.b23x6 b.l21x7 24.06133.36YesNo175
73b.b23x6 b.b24x6 18.10769.165YesYes178
74b.b21x7 b.b24x6 16.16866.27YesYes058
75b.b22x1 b.l25x6 16.12966.47NoYes088
76b.b22x1 b.b22x2 15.81224NoNo088
77b.b22x2 b.b26x3 15.50853.755NoYes086
78b.b21x1 g.h1x14 17.15313.25YesNo079
79b.b15x1 b.b16x6 10.39039.02YesYes698
807x34 Lig 16.031310.44YesYes230
816x33 6x37 19.09263.07NoNo077
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
2x562x603.052NoYes7621
2x567x423.362NoYes7722
2x607x389.2752YesYes6512
2x607x427.332YesYes6712
2x60Lig4.5052YesYes6010
2x63E1x504.112NoYes5812
2x63Lig10.772NoYes5010
2x647x314.4652YesNo5311
2x647x347.22YesYes5311
2x647x353.632YesNo5312
2x647x3811.4352YesYes5512
2x64Lig4.5152YesYes5010
E1x49Lig5.010NoYes5010
3x25E1x503.922NoYes9822
3x29E1x503.7052YesYes4812
E1x50E24.932YesYes8321
E1x50E2x5015.022YesNo8922
3x25E24.5752NoYes9321
3x25E2x507.282NoNo9922
3x283x292.770NoYes5421
3x294x6515.792YesYes4511
3x29E2x503.6852YesNo4912
3x29Lig4.92YesYes4010
4x63E26.960NoYes4321
4x644x6511.4152YesYes4521
4x64E2x523.4752YesYes4421
4x64E26.752YesYes4321
4x645x368.7452YesYes4421
4x65E2x529.042YesYes5411
4x65Lig8.942YesYes5010
E2E226.382YesYes3311
E2Lig13.82YesYes3010
E2E2x5120.1852YesNo3411
E2x51E2x523.8152NoYes4411
E2x51Lig62NoYes4010
5x36E2x528.6452YesYes4411
E2x52Lig5.452YesYes4010
5x35E272NoYes2321
5x36E242YesYes4311
5x366x598.52YesNo4412
5x36Lig4.442YesYes4010
6x517x343.3850YesYes7321
6x54E37.312NoYes4321
6x547x347.292NoYes4321
6x58E37.8650NoYes4321
E3E34.832YesYes3311
7x30E36.7152NoYes4311
E3Lig18.0052YesYes3010
7x277x305.4950NoNo3421
7x30Lig7.2752NoYes4010
7x317x3510.882NoNo3312
7x31Lig6.9352NoYes3010
7x347x3816.9252YesYes3512
7x34Lig10.442YesYes3010
7x387x424.92YesYes5722
E1Lig2.8250NoYes4010
6x57E32.0950NoYes4321
3x22E20.720NoYes3321

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
86.67Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
81.25Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
81.25Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
81.25Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
75.00Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
66.67Single7XJJGalanin7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
66.67Consensusgo_galaninOrthosteric Ligand7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
61.11Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
55.00Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
52.94Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
52.94Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
52.94Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
52.63Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/&β;1/&γ;2
52.63Single6YVRNTS8-136YVR-NTS1-NTS8-13
52.38Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/&β;1/&γ;1
52.17Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
50.00Single4BUONeurotensin4BUO-NTS1-Neurotensin
50.00Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
50.00Single8JPCNeurotensin 8-138JPC-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
50.00Consensusc5a1_off_ortoalloOrthosteric Ligand6C1Q-C5a1-PMX53-NDT9513727 6C1R-C5a1-PMX53-Avacopan; Na
48.00Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
48.00Consensusbb1_onOrthosteric Ligand8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
48.00Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
47.83Single7XNACYN1548067XNA-SST2-CYN154806
47.83Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
47.62Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2 8I95-C3aB-EP54-Go/&β;1/&γ;2
47.62Consensusgs_bombesinOrthosteric Ligand8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
46.67Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
45.45Consensusfpr-alx_onOrthosteric Ligandfpr1-alx_on fpr2-alx_on
45.45Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
45.00Single4GRVNeurotensin 8-134GRV-NTS1-Neurotensin 8-13
45.00Single4XEENeurotensin4XEE-NTS1-Neurotensin
45.00Single4XESNeurotensin4XES-NTS1-Neurotensin
45.00Single6OS2TRV0266OS2-AT1-TRV026
45.00Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2
44.44Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
44.44Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
44.00Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
43.75Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
43.48Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
43.48Consensusalpha1_offOrthosteric Ligandalpha1a_off alpha1b_off
43.48Consensussst_offOrthosteric Ligandsst2_off
42.86Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
42.86Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
42.31Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
42.31Consensusgi_neuromedinOrthosteric Ligand7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
42.11Single8FN1Neurotensin/neuromedin N8FN1-NTS1-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
41.67Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
41.67Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
41.67Consensusgi_formylpeptideOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
41.67Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
41.67Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
41.38Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
41.18Single4BWBNeurotensin4BWB-NTS1-Neurotensin
41.18Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
41.18Consensusm2_on_alloOther Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
40.91Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
40.91Consensusfpr2-alx_onOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
40.91Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
40.91Consensusmotilin_onOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
40.74Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
40.00Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
40.00Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1
40.00Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/&β;1/&γ;1
40.00Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2
40.00Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
40.00Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2
40.00Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
40.00Consensuschemerin_onOrthosteric Ligandcml1_on
40.00Consensuscml1_onOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
40.00Consensusgi_somatostatinOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
40.00Consensusrelaxin_onOrthosteric Ligandrxfp4_on
39.29Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
39.29Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
39.13Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
39.13Consensussst_onOrthosteric Ligandsst2_on sst4_on
38.89Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
38.89Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
38.89Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
38.46Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
38.46Consensusbombesin_onOrthosteric Ligandbb2_on bb1_on
38.46Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
38.10Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/&β;1/γ1
38.10Single7Y66BM2137Y66-C5a1-BM213-Gi1/&β;1/&γ;2
38.10Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
38.10Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2
38.10Single8IBUErythromycin A8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
38.10Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
38.10Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
38.10Consensusdp_offOrthosteric Liganddp2_off
37.93Single6IGKEndothelin-36IGK-ETB-Endothelin-3
37.93Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
37.93Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
37.93Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
37.50Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
37.50Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
37.04Single4XT3Fractalkine4XT3-US28-Fractalkine
37.04Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
37.04Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
36.84Single5T04Neurotensin5T04-NTS1-Neurotensin
36.84Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
36.84Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
36.84Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
36.84Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/&β;1/&γ;2
36.84Single8K5DGSK2560738K5D-HCA2-GSK256073
36.36Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
36.36Consensusgi_neurotensinOrthosteric Ligand7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
36.00Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
36.00Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
36.00Consensuscx3cr1_onOrthosteric Ligand7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
36.00Consensusgi_chemerinOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
35.71Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
35.71Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
35.71Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
35.29Single3OE9IT1t3OE9-CXCR4-IT1t
35.29Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
35.29Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
35.29Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
35.29Consensusm4_on_alloOther Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
35.00Single6D26Fevipiprant6D26-DP2-Fevipiprant
35.00Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
35.00Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
34.78Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
34.78Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
34.78Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
34.78Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
34.78Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
34.62Single6JODAngiotensin II6JOD-AT2-Angiotensin II
34.62Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
34.62Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
34.62Consensusnmur_onOrthosteric Ligandnmur1_on nmur2_on
34.48Single8IY6Endothelin-18IY6-ETB-Endothelin-1
34.48Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
34.38Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
33.33Single4BV0Neurotensin4BV0-NTS1-Neurotensin
33.33Single4XT1Fractalkine4XT1-US28-Fractalkine
33.33Single5GLHEndothelin-15GLH-ETB-Endothelin-1
33.33Single6OS1TRV0266OS1-AT1-TRV026
33.33Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
33.33Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
33.33Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
33.33Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
33.33Single7W0OElabela7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
33.33Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
33.33Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
33.33Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
33.33Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
33.33Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
33.33Single8FMZNeurotensin/neuromedin N8FMZ-NTS1-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
33.33Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2
33.33Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/&β;1/&γ;2
33.33Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
33.33Consensuscck_onOrthosteric Ligandccka_on cckb_on
33.33Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
33.33Consensusgs_bradykininOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Consensusgs_neuromedinOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Consensusnts1_on_alloOrthosteric Ligand8JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
33.33Consensussst2_onOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
32.26Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
32.14Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
32.14Single7SK3CXCL127SK3-ACKR3-CXCL12
32.14Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
32.14Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
32.14Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
32.00Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
32.00Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
32.00Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
32.00Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
32.00Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
32.00Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
32.00Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
32.00Consensuscx3cr_onOrthosteric Ligandcx3cr1_on
31.82Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
31.82Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
31.82Single8I95EP548I95-C3aB-EP54-Go/&β;1/&γ;2
31.82Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2
31.82Single8J6DEP1418J6D-C3aB-EP141-Go/&β;1/&γ;2
31.82Single8JPBNeurotensin 8-138JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
31.82Consensusnts1_offOrthosteric Ligand6Z4Q-NTS1-SR142948A 6Z4S-NTS1-SR48692
31.82Consensusnts1_onOrthosteric Ligand6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
31.82Consensusnts_offOrthosteric Ligandnts1_off
31.82Consensusnts_onOrthosteric Ligandnts1_on
31.58Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
31.58Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
31.58Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
31.58Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
31.58Single8JIMMMF8JIM-HCA2-MMF-Gi1/&β;1/&γ;2
31.58Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
31.58Consensusm1_off_alloOther Ligand6WJC-M1-Atropine-Muscarinic toxin 7
31.25Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
31.03Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
31.03Consensusendothelin_onOrthosteric Ligandetb_on eta_on
30.77Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1
30.77Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
30.77Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
30.77Consensusangiotensin_onOrthosteric Ligandat1_on
30.77Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
30.77Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
30.77Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.77Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
30.43Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2
30.43Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
30.43Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
30.30Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
30.30Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
30.30Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
30.00Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
30.00Single6D27CAY104716D27-DP2-CAY10471
30.00Single6IGLIRL16206IGL-ETB-IRL1620
30.00Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/&β;1/&γ;2
30.00Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
30.00Single7VGXNeuropeptide Y7VGX-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
30.00Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
30.00Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/&β;1/&γ;2
30.00Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
30.00Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
30.00Consensusgi_hcaOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
30.00Consensusgi_hcarOrthosteric Ligandgi_hca
30.00Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
30.00Consensushca2_onOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
29.63Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
29.63Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
29.63Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
29.63Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
29.63Consensusnmur2_onOrthosteric Ligand7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.41Single3OE6IT1t3OE6-CXCR4-IT1t
29.17Single6KNMJN241-96KNM-Apelin-JN241-9
29.17Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
29.17Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.17Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
29.17Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
29.17Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
29.17Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
29.17Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.17Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
28.57Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
28.57Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
28.57Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
28.57Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
28.57Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.57Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
28.57Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
28.57Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
28.57Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
28.57Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
28.57Single7Y27Somatostatin-147Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
28.57Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.57Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
28.57Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
28.57Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.57Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
28.57Consensusgs_sstOrthosteric Ligand7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
28.12Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
28.00Single7F8XNN90567F8X-CCKA-NN9056
28.00Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
28.00Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
28.00Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.00Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
28.00Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
28.00Consensusnmur1_onOrthosteric Ligand7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.00Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
27.59Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
27.59Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
27.59Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
27.59Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
27.59Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
27.27Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
27.27Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
27.27Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
27.27Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
27.27Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.27Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
27.27Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.27Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
27.27Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
27.27Consensusgs_compl-peptideOrthosteric Ligand8I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.92Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
26.92Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
26.92Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.92Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
26.67Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.67Consensusetb_onOrthosteric Ligand8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
26.32Single3ODUIT1t3ODU-CXCR4-IT1t
26.32Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
26.32Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
26.32Single8FN0Neurotensin/neuromedin N8FN0-NTS1-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
26.32Single8GNGIstradefylline8GNG-A2A-Istradefylline
26.32Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2
26.09Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
26.09Single7K15MKD0467K15-BLT1-MKD046-Na
26.09Single7Y24Octreotide7Y24-SST2-Octreotide-Go/&β;1/&γ;2
26.09Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.09Consensusblt1_offOrthosteric Ligand7K15-BLT1-MKD046-Na
26.09Consensusblt_offOrthosteric Ligandblt1_off
26.09Consensuschemokine_offOrthosteric Ligandcxcr_off
26.09Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II
26.09Consensuscxcr_offOrthosteric Ligandcxcr4_off
26.09Consensusleuko_offOrthosteric Ligandblt_off cyslt_off
25.93Single3OE0CVX153OE0-CXCR4-CVX15
25.93Single7F4DAlpha-MSH7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
25.93Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
25.93Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
25.81Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
25.81Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
25.81Single8FEGPRD_0025178FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
25.81Consensusgs_endothelinOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
25.00Single5K2BZM2413855K2B-A2A-ZM241385-Na
25.00Single5NLXZM2413855NLX-A2A-ZM241385-Na
25.00Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
25.00Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
25.00Single5UVIZM2413855UVI-A2A-ZM241385
25.00Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
25.00Single6MH8ZM2413856MH8-A2A-ZM241385
25.00Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
25.00Single7C61Ergotamine7C61-5-HT1B-Ergotamine
25.00Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
25.00Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
25.00Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
25.00Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
25.00Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
25.00Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/&β;1/&γ;2
25.00Single8JERAcipimox8JER-HCA2-Acipimox-Go/&β;1/&γ;2
25.00Single8JHNMMF8JHN-HCA2-MMF-Go/&β;1/&γ;2
25.00Single8K5CAcipimox8K5C-HCA2-Acipimox
25.00Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
25.00Consensuscxcr_onOrthosteric Ligandcxcr1_on cxcr2_on
25.00Consensusgs_orexinOrthosteric Ligand7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
25.00Consensushca_onOrthosteric Ligandhca2_on hca3_on
25.00Consensushcar_onOrthosteric Ligandhca_on
25.00Consensuslh_on_alloOther Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Consensusorexin_onOrthosteric Ligandox2_on
24.24Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
24.14Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
24.14Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
24.14Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
24.14Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
24.14Consensusbk1_onOrthosteric Ligand7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
24.14Consensusgs_melanocortinOrthosteric Ligand7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2
24.14Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
24.00Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
24.00Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
24.00Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
24.00Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
24.00Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
24.00Single7XN9L-054,5227XN9-SST2-L-054,522
24.00Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
24.00Single8INRAlpha-MSH8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
24.00Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
24.00Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
24.00Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
24.00Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
24.00Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
24.00Consensuslpl_offOrthosteric Ligands1p_off lpa_off
24.00Consensuslpl_onOrthosteric Ligands1p_on lpa_on
24.00Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
23.81Single3EMLZM2413853EML-A2A-ZM241385
23.81Single4YAYZD-71554YAY-AT1-ZD-7155
23.81Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
23.81Single5K2AZM2413855K2A-A2A-ZM241385-Na
23.81Single5VRAZM2413855VRA-A2A-ZM241385-Na
23.81Single6LPJZM2413856LPJ-A2A-ZM241385-Na
23.81Single6LPKZM2413856LPK-A2A-ZM241385-Na
23.81Single6S0LZM2413856S0L-A2A-ZM241385
23.81Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
23.81Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
23.81Single7V3ZPubMed 1048957V3Z-CB1-PubMed 104895
23.81Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
23.81Consensuscb1_on_alloOrthosteric Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
23.81Consensushca3_onOrthosteric Ligand8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
23.53Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/&β;1/&γ;2
23.33Single6FJ3PTH6FJ3-PTH1-PTH
23.33Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
23.33Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
23.33Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.33Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
23.33Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
23.08Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
23.08Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
23.08Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
23.08Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
23.08Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
23.08Single8GHVPubChem 1459649038GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
23.08Single8J6RMK68928J6R-HCA2-MK6892-Gi1/&β;1/&γ;2
23.08Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
23.08Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
23.08Consensusmop_offOrthosteric Ligand7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
23.08Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
22.86Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
22.73Single5IUAQ274563485IUA-A2A-Q27456348-Na
22.73Single5N2SPSB365N2S-A1-PSB36
22.73Single6LPLZM2413856LPL-A2A-ZM241385-Na
22.73Single6S0QZM2413856S0Q-A2A-ZM241385
22.73Single6WQAZM2413856WQA-A2A-ZM241385-Na
22.73Single6Z4SSR486926Z4S-NTS1-SR48692
22.73Single7RM5ZM2413857RM5-A2A-ZM241385-Na
22.73Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
22.73Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
22.73Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
22.73Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
22.73Single8FYNZM2413858FYN-A2A-ZM241385-Na
22.73Single8GNEKW-63568GNE-A2A-KW-6356-Na
22.73Single8QOTNanobody E8QOT-μ-Nanobody E
22.73Consensuscb2_onOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
22.58Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
22.58Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
22.58Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
22.22Single3OE8IT1t3OE8-CXCR4-IT1t
22.22Single4XNWMRS25004XNW-P2Y1-MRS2500
22.22Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
22.22Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
22.22Single7SK5CXCL127SK5-ACKR3-CXCL12
22.22Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
22.22Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
22.22Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.22Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
22.22Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
22.22Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
21.88Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
21.88Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
21.88Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
21.74Single7F1TMIP-1a7F1T-CCR5-MIP-1a
21.74Single7FEEPubMed 1048957FEE-CB1-PubMed 104895-ZCZ011
21.74Single7PX4PSB-21137PX4-A2A-PSB-2113
21.74Single7WV9PubMed 1048957WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
21.74Single7XOWGastrin7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
21.74Single7XOXCholecystokinin-87XOX-CCKB-Cholecystokinin-8-Gq/&β;1/&γ;2
21.43Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
21.43Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;2
21.43Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
21.43Consensusmc5_onOrthosteric Ligand8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
21.43Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
21.21Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
21.05Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
21.05Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2
21.05Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/&β;1/&γ;2
21.05Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2
21.05Single8IJANiacin8IJA-HCA2-Niacin-Gi1/&β;1/&γ;2
21.05Single8JILNiacin8JIL-HCA2-Niacin-Gi1/&β;1/&γ;2
21.05Single8K5BNiacin8K5B-HCA2-Niacin
21.05Consensusgo_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
21.05Consensusgo_proteinOrthosteric Ligandgo_chemokine
20.83Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
20.83Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
20.83Single6KQIPubMed 1048956KQI-CB1-PubMed 104895-ORG27569
20.83Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.83Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.83Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
20.83Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
20.83Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.83Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
20.83Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.83Consensuscannabinoid_onOrthosteric Ligandcb1_on cb2_on
20.83Consensuscb1_off_alloOrthosteric Ligand6KQI-CB1-PubMed 104895-ORG27569
20.83Consensuscb1_onOrthosteric Ligand8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
20.83Consensusgi_cannabinoidOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
20.83Consensusgpr119_onOrthosteric Ligand7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
20.83Consensusgs_bileacidOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
20.83Consensusgs_steroidOrthosteric Ligandgs_bileacid
20.69Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
20.69Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
20.69Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
20.69Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
20.69Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.69Single8IHFMK68928IHF-HCA2-MK6892-Gi1/&β;1/&γ;2
20.69Single8J6IMK68928J6I-HCA2-MK6892-Gi1/&β;1/&γ;2
20.69Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
20.59Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
20.59Consensusglp_onOrthosteric Ligandglp1_on glp2_on
20.59Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
20.51Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
20.00Single3PWHZM2413853PWH-A2A-ZM241385
20.00Single3VG9ZM2413853VG9-A2A-ZM241385-Antibody
20.00Single5K2DZM2413855K2D-A2A-ZM241385
20.00Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
20.00Single5ZKQABT-4915ZKQ-PAF-ABT-491
20.00Single6JZHZM2413856JZH-A2A-ZM241385-Na
20.00Single6PS7ZM2413856PS7-A2A-ZM241385-Na
20.00Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
20.00Single6WWZCCL206WWZ-CCR6-CCL20-Go/&β;1/&γ;2
20.00Single7EZCUKA7EZC-A2A-UKA
20.00Single7F8YDevazepide7F8Y-CCKA-Devazepide
20.00Single7KH0Acyclovir triphosphate7KH0-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
20.00Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
20.00Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
20.00Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
20.00Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
20.00Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
20.00Single8DWHCompound-168DWH-MRGPRX1-Compound-16-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
20.00Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/&β;1/&γ;2
20.00Single8IHKAcifran8IHK-HCA3-Acifran
20.00Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/&β;1/&γ;2
20.00Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
20.00Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
20.00Single8WRZ8D08WRZ-CB1-8D0-Arrestin1
20.00Consensusbileacid_onOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
20.00Consensuscckb_onOrthosteric Ligand7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
20.00Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
20.00Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
20.00Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
20.00Consensussteroid_onOrthosteric Ligandbileacid_on
19.44Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
19.44Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
19.44Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
19.44Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
19.35Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
19.35Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/&β;1/&γ;2
19.35Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
19.35Single7D3SSecretin7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
19.35Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
19.35Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
19.35Consensusghrh_onOrthosteric Ligand7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
19.35Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
19.23Single4UG2CGS216804UG2-A2A-CGS21680
19.23Single5WF6UK-4320975WF6-A2A-UK-432097
19.23Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
19.23Single7XY6PubChem 117178317XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
19.23Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
19.23Single8IYHMK68928IYH-HCA2-MK6892-Go/&β;1/&γ;2
19.23Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
19.23Single8XZFWN5618XZF-Apelin-WN561-Gi1/&β;1/&γ;2
19.23Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
19.23Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
19.05Single3REYPubChem 56973REY-A2A-PubChem 5697
19.05Single5IU4ZM2413855IU4-A2A-ZM241385-Na
19.05Single5IU7Q274563465IU7-A2A-Q27456346-Na
19.05Single5IUBQ274563445IUB-A2A-Q27456344-Na
19.05Single5JTBZM2413855JTB-A2A-ZM241385
19.05Single5K2CZM2413855K2C-A2A-ZM241385-Na
19.05Single5NM4ZM2413855NM4-A2A-ZM241385-Na
19.05Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
19.05Single6ZDVPubChem 9840736ZDV-A2A-PubChem 984073-Na
19.05Single6ZINSR486926ZIN-NTS1-SR48692
19.05Single7AROLUF58337ARO-A2A-LUF5833-Na
19.05Single7BB6Acyclovir triphosphate7BB6-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
19.05Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
19.05Single7T32ZM2413857T32-A2A-ZM241385
19.05Single7XOVSR1461317XOV-CCKA-SR146131-Gs/&β;1/&γ;2
19.05Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2
19.05Single8GURPubChem 1048958GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2
19.05Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
19.05Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
19.05Consensush3_on_alloOrthosteric Ligand7F61-H3-PF-03654746-Cholesterol
18.92Consensuspth_onOrthosteric Ligandpth1_on pth2_on
18.75Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
18.75Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
18.75Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
18.75Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
18.75Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
18.75Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
18.52Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
18.52Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
18.52Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
18.52Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
18.18Single4EIYZM2413854EIY-A2A-ZM241385-Na
18.18Single5IU8Q274563475IU8-A2A-Q27456347-Na
18.18Single5OLGZM2413855OLG-A2A-ZM241385-Na
18.18Single5UIGJ3.651.884G5UIG-A2A-J3.651.884G
18.18Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
18.18Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
18.18Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
18.18Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
18.18Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
18.18Single7PYRPSB-21157PYR-A2A-PSB-2115
18.18Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
18.18Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
18.18Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
18.18Single8CU6LJ-45178CU6-A2A-LJ-4517
18.18Single8EFQDamgo8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
18.18Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
18.18Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
18.18Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/&β;1/&γ;2
18.18Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
18.18Consensusa2_offOrthosteric Liganda2a_off
18.18Consensusa2a_offOrthosteric Ligand8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 5UIG-A2A-J3.651.884G 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-PubChem 168451710 5K2D-A2A-ZM241385
18.18Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
18.18Consensuscck_offOrthosteric Ligandccka_off
18.18Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
18.18Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
18.18Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
18.18Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
18.18Consensusprostanoid_offOrthosteric Ligandep_off tp_off dp_off
18.18Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
18.18Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
17.95Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
17.95Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
17.86Single3QAKUK-4320973QAK-A2A-UK-432097
17.86Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
17.65Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
17.65Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
17.65Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
17.65Consensusgs_crfOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
17.39Single5N2RPubChem 92460631; psb365N2R-A2A-PubChem 92460631; psb36-Na
17.39Single5NM2ZM2413855NM2-A2A-ZM241385-Na
17.39Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
17.39Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
17.39Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
17.39Single7CFNINT-7777CFN-GPBA-INT-777-Gs/&β;1/&γ;2
17.39Single7CKXA776367CKX-D1-A77636-Gs/&β;1/&γ;2
17.39Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
17.39Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
17.39Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
17.39Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
17.39Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
17.39Single8ID9Eicosapentaenoic acid8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
17.39Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
17.24Single5WF5UK-4320975WF5-A2A-UK-432097
17.24Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
17.24Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
17.24Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
17.14Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
17.14Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
17.14Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
16.67Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
16.67Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
16.67Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
16.67Single5TZR-5TZR-FFA1 (GPR40)-MK8666
16.67Single5XR8AM8415XR8-CB1-AM841
16.67Single5XRAAM115425XRA-CB1-AM11542
16.67Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
16.67Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
16.67Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
16.67Single7B6WCyclazosin7B6W-α1b-Cyclazosin
16.67Single7CKYPW04647CKY-D1-PW0464-Gs/&β;1/&γ;2
16.67Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
16.67Single7JV5SKF812977JV5-D1-SKF81297-Gs/&β;1/&γ;2
16.67Single7JVPSKF839597JVP-D1-SKF83959-Gs/&β;1/&γ;2
16.67Single7TUYGSK682753A7TUY-GPR183-GSK682753A
16.67Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
16.67Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
16.67Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
16.67Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
16.67Single7XTQR3997XTQ-GPBA-R399-Gs/&β;1/&γ;2
16.67Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
16.67Single8A2OTheophylline8A2O-A2A-Theophylline-Na
16.67Single8GUSHU-3088GUS-CB2-HU-308-Gi1/&β;1/&γ;2
16.67Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
16.67Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2
16.67Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
16.67Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Consensusadenosine_offOrthosteric Liganda1_off a2_off
16.67Consensusalpha1b_offOrthosteric Ligand7B6W-α1b-Cyclazosin
16.67Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
16.67Consensusffa4_onOrthosteric Ligand8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Consensusgi_ffaOrthosteric Ligand8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
16.67Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
16.67Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A2A-NECA-Gs/&β;1/&γ;1 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
16.67Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
16.67Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
16.67Consensuslpa_offOrthosteric Ligandlpa1_off
16.67Consensuslpa_onOrthosteric Ligandlpa1_on
16.67Consensussst4_onOrthosteric Ligand7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
16.67Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
16.67Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
16.22Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
16.13Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
16.13Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
16.13Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
16.13Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
16.00Single4PY02MeSATP4PY0-P2Y12-2MeSATP
16.00Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
16.00Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
16.00Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/&β;1/&γ;2
16.00Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/&β;1/&γ;2
16.00Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
16.00Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2
16.00Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
16.00Single7WCNAR2314537WCN-GPR119-AR231453-Gs/&β;1/&γ;2
16.00Single7XMTJ-21567XMT-SST4-J-2156-Gi1/&β;1/&γ;2
16.00Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
16.00Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
16.00Single8IJDMK68928IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
16.00Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
16.00Single8JJLOlodaterol8JJL-β2-Olodaterol
16.00Single8JWYPubChem 1684517108JWY-A2A-PubChem 168451710
16.00Single8JWZAB9288JWZ-A2A-AB928-Na
16.00Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/&β;1/&γ;2
16.00Single8WU1KCA8WU1-CB1-KCA-Arrestin1
16.00Consensusat2_offOrthosteric Ligand7JNI-AT2-Olodanrigan
16.00Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
16.00Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
16.00Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
16.00Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
16.00Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
16.00Consensustsh_on_alloOther Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
15.79Single5WKTOctyl Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
15.79Single6ME5Agomelatine6ME5-MT1-Agomelatine
15.79Single8J6QBeta-hydroxybutyrate8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
15.79Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
15.79Consensusadgrg3_onOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
15.79Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
15.62Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
15.62Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
15.62Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
15.38Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
15.38Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
15.38Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
15.38Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
15.38Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
15.38Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
15.38Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/&β;1/&γ;2
15.38Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
15.38Single7XJISolabegron7XJI-β3-Solabegron-Gs/&β;1/&γ;2
15.38Single7XK2MK68927XK2-HCA2-MK6892-Gi1/&β;1/&γ;2
15.38Single7XZ6APD6687XZ6-GPR119-APD668-Gs/&β;1/&γ;2
15.38Single8GAGYVF8GAG-CB1-YVF-Gi1/&β;1/&γ;2
15.38Consensusadgrg2_onOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
15.38Consensusendothelin_offOrthosteric Ligandetb_off
15.38Consensusetb_offOrthosteric Ligand5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500 5X93-ETB-K-8794
15.38Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
15.15Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
15.15Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
15.15Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
15.15Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
15.15Consensusgo_class-b1Orthosteric Ligandgo_crf
15.15Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
15.00Single4O9RCyclopamine4O9R-SMO-Cyclopamine
15.00Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
15.00Single7UL2SR486927UL2-NTS1-SR48692-Na
15.00Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
15.00Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
15.00Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
15.00Single8IY9Niacin8IY9-HCA2-Niacin-Go/&β;1/&γ;2
15.00Consensusclass-t_onOrthosteric Ligandtaste2_on
15.00Consensusgs_class-tOrthosteric Ligandgs_taste
15.00Consensusgs_tasteOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
15.00Consensusnts1_off_alloOrthosteric Ligand7UL2-NTS1-SR48692-Na
15.00Consensustaste2_onOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
14.81Single5ZTYAM102575ZTY-CB2-AM10257
14.81Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
14.81Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
14.81Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
14.81Consensusclass-d_offOrthosteric Ligandste2_off
14.81Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
14.71Single6LMLGlucagon6LML-Glucagon-Glucagon
14.71Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
14.71Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
14.29Single2X72All-trans-retinal2X72-Rhodopsin-All-trans-retinal-Gt(CT)
14.29Single3VGAZM2413853VGA-A2A-ZM241385-Antibody
14.29Single4IARErgotamine4IAR-5-HT1B-Ergotamine
14.29Single4QINSAG1.54QIN-SMO-SAG1.5
14.29Single6NWEOctyl Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
14.29Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
14.29Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
14.29Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
14.29Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
14.29Single7QA8Peptide7QA8-STE2-Peptide
14.29Single7QA8Peptide7QA8-STE2-Peptide
14.29Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
14.29Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
14.29Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
14.29Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
14.29Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
14.29Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
14.29Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Single7XRRLemborexant7XRR-OX2-Lemborexant
14.29Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
14.29Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
14.29Single8G59TUG-8918G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
14.29Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
14.29Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
14.29Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
14.29Consensusa2a_off_alloOrthosteric Ligand6ZDR-A2A-HMS1413f12-Na 6GT3-A2A-Imaradenant-Na 8CU7-A2A-LJ-4517-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PubChem 92460631; psb36-Na 5MZJ-A2A-Theophylline-Na 5OLO-A2A-Tozadenant-Na 5OLH-A2A-Vipadenant-Na 5NM4-A2A-ZM241385-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5MZP-A2A-Caffeine-Na 8CIC-A2A-Etrumadenant-Na
14.29Consensusclass-d_offOrthosteric Ligandste2_off
14.29Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
14.29Consensusp2y_offOrthosteric Ligandp2y1_off p2y12_off
13.79Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
13.79Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
13.79Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
13.79Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
13.79Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/&β;1/&γ;2
13.79Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
13.79Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
13.79Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
13.79Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
13.64Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
13.64Single5TE3Octyl Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
13.64Single6AQFZM2413856AQF-A2A-ZM241385
13.64Single6IQLL7458706IQL-D4-L745870
13.64Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
13.64Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
13.64Single6V9SGTPL114036V9S-OX1-GTPL11403
13.64Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
13.64Single6ZG9GSK10347026ZG9-M1-GSK1034702
13.64Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
13.64Single7VV6C48/807VV6-MRGPRX2-C48/80
13.64Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
13.64Single8K2WAMG4878K2W-CXCR3-AMG487
13.64Consensusffa2_onOrthosteric Ligand8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
13.64Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
13.64Consensusgi_class-fOrthosteric Ligandgi_frizzled
13.64Consensusgi_frizzledOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
13.64Consensusgnrh_offOrthosteric Ligandgnrh1_off
13.64Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
13.64Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
13.64Consensuss1p_offOrthosteric Ligands1p1_off
13.51Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
13.33Single6PT2KGCHM076PT2-δ-KGCHM07
13.33Single6W25SHU91196W25-MC4-SHU9119-Ca
13.33Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
13.33Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
13.16Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
13.04Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
13.04Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
13.04Single5DHGPubChem 250014125DHG-NOP-PubChem 25001412
13.04Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
13.04Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
13.04Single5UENDU1725UEN-A1-DU172
13.04Single6IIVDaltroban6IIV-TP-Daltroban
13.04Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2
13.04Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
13.04Single6TOTLemborexant6TOT-OX1-Lemborexant
13.04Single7CFMP3957CFM-GPBA-P395-Gs/&β;1/&γ;2
13.04Single7F83PF-051904577F83-Ghrelin-PF-05190457
13.04Single7UL4Alvimopan7UL4-μ-Alvimopan
13.04Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/&β;1/&γ;2
13.04Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
13.04Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
13.04Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
13.04Single8EJCTAK-8758EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
13.04Single8EJKTAK-8758EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
13.04Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/&β;1/&γ;2
13.04Consensus5ht1a_onOrthosteric Ligand8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
13.04Consensusadenosine_onOrthosteric Liganda1_on a2_on
13.04Consensusfsh_on_alloOther Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
13.04Consensushcar_offOrthosteric Ligandsuccinate_off
13.04Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
13.04Consensusnucleotide_onOrthosteric Ligandadenosine_on
13.04Consensussmo_offOrthosteric Ligand5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
13.04Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
13.04Consensustp_offOrthosteric Ligand6IIV-TP-Daltroban 6IIU-TP-Ramatroban
12.90Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
12.90Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
12.90Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
12.90Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
12.82Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
12.82Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
12.50Single4JKVTaladegib (LY2940680)4JKV-SMO-Taladegib (LY2940680)
12.50Single4PHUFasiglifam4PHU-FFA1 (GPR40)-Fasiglifam
12.50Single5WIUNemonapride5WIU-D4-Nemonapride
12.50Single5WIVNemonapride5WIV-D4-Nemonapride-Na
12.50Single5WQCEMPA5WQC-OX2-EMPA
12.50Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
12.50Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
12.50Single6DDEDamgo6DDE-μ-Damgo-Gi1/&β;1/&γ;2
12.50Single6GDGNECA6GDG-A2A-NECA-Gs/&β;1/&γ;1
12.50Single6LUQHaloperidol6LUQ-D2-Haloperidol
12.50Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
12.50Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
12.50Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
12.50Single7C4SS1P7C4S-S1P3-S1P
12.50Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
12.50Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
12.50Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
12.50Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
12.50Single7YXAONO-54306087YXA-S1P5-ONO-5430608
12.50Single8DZQmomSalB8DZQ-κ-momSalB-Go/&β;1/&γ;2
12.50Single8GDAL9026888GDA-EP4-L902688-Gs/&β;1/&γ;2
12.50Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2
12.50Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
12.50Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
12.50Consensusa1_on_alloOrthosteric Ligand7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
12.50Consensusa2a_onOrthosteric Ligand6GDG-A2A-NECA-Gs/&β;1/&γ;1
12.50Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
12.50Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRR-D1-Rotigotine-Gs/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
12.50Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
12.50Consensusd4_offOrthosteric Ligand5WIU-D4-Nemonapride
12.50Consensusd4_off_alloOrthosteric Ligand5WIV-D4-Nemonapride-Na
12.50Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
12.50Consensusep_offOrthosteric Ligandep4_off
12.50Consensusgo_opioidOrthosteric Ligand8DZQ-κ-momSalB-Go/&β;1/&γ;2
12.12Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
12.12Consensusclass-d_onOrthosteric Ligandste2_on
12.12Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
12.12Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
12.00Single3SN6BI1671073SN6-β2-BI167107-Gs/&β;1/&γ;2
12.00Single4RWADIPP-NH24RWA-δ-DIPP-NH2
12.00Single5V56TC1145V56-SMO-TC114
12.00Single5V57TC1145V57-SMO-TC114
12.00Single5X93K-87945X93-ETB-K-8794
12.00Single6J20Aprepitant6J20-NK1-Aprepitant
12.00Single6J21Aprepitant6J21-NK1-Aprepitant
12.00Single6NI3BI1671076NI3-β2-BI167107-Gs/&β;1/&γ;2
12.00Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
12.00Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2
12.00Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2
12.00Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
12.00Single7EW7PubChem 40774607EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
12.00Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
12.00Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
12.00Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
12.00Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
12.00Single7W41PD1762527W41-BB2-PD176252
12.00Single8DZPmomSalB8DZP-κ-momSalB-Gi1/&β;1/&γ;2
12.00Single8E0GBU728E0G-μ-BU72
12.00Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
12.00Single8EFLSR170188EFL-μ-SR17018-Gi1/&β;1/&γ;2
12.00Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
12.00Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
12.00Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
12.00Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
12.00Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
12.00Consensus5ht1b_onOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
12.00Consensusa2_onOrthosteric Liganda2a_on a2b_on
12.00Consensusangiotensin_offOrthosteric Ligandat1_off at2_off
12.00Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
12.00Consensusbombesin_offOrthosteric Ligandbb2_off
12.00Consensusgi_dopamineOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
12.00Consensusgi_muscarinicOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
12.00Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2
12.00Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
12.00Consensusnpy_offOrthosteric Ligandnpy2_off npy1_off
12.00Consensuss1p2_onOrthosteric Ligand7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
12.00Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
12.00Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
11.90Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
11.76Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
11.76Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
11.76Single6W25Ca6W25-MC4-SHU9119-Ca
11.76Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
11.76Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
11.76Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
11.76Consensusccr8_offOrthosteric Ligand8TLM-CCR8-Anti-murine CCR8 antibody
11.76Consensusgi_class-dOrthosteric Ligandgi_ste
11.76Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
11.76Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
11.63Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
11.63Consensusgs_ctOrthosteric Ligand7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
11.54Single5X33BIIL2605X33-BLT1-BIIL260
11.54Single6A93Risperidone6A93-5-HT2A-Risperidone
11.54Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
11.54Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
11.54Single6IIURamatroban6IIU-TP-Ramatroban
11.54Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
11.54Single6MXTSalmeterol6MXT-β2-Salmeterol
11.54Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
11.54Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
11.54Single6ZG4HTL00099366ZG4-M1-HTL0009936
11.54Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1
11.54Single7DFPSpiperone7DFP-D2-Spiperone
11.54Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
11.54Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
11.54Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
11.54Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
11.54Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/&β;1/&γ;2
11.54Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
11.54Single7YITNalfurafine7YIT-κ-Nalfurafine
11.54Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
11.54Single8GCPPGE28GCP-EP4-PGE2-Gi1/&β;1/&γ;2
11.54Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
11.54Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.54Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
11.54Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
11.54Consensusep_onOrthosteric Ligandep4_on ep2_on ep3_on
11.54Consensusgi_prostanoidOrthosteric Ligand8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GDC-EP3-PGE2-Gi1/&β;1/&γ;2 8GCM-EP4-L902688-Gi1/&β;1/&γ;2
11.54Consensusgs_trhOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
11.54Consensusopioid_offOrthosteric Ligandkop_off mop_off nop_off dop_off
11.54Consensuspeptide_offOrthosteric Ligandopioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
11.54Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
11.43Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
11.43Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
11.43Consensuscalcitonin_onOrthosteric Ligandct_on ctlike_on
11.43Consensuscrf1_onOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
11.11Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
11.11Single6DDFDamgo6DDF-μ-Damgo-Gi1/&β;1/&γ;2
11.11Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
11.11Single6IBLArformoterol6IBL-β1-Arformoterol
11.11Single6K1QIRL25006K1Q-ETB-IRL2500
11.11Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
11.11Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2
11.11Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
11.11Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
11.11Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
11.11Single7TYLAmylin7TYL-CT-Amylin-Gs/&β;1/&γ;2
11.11Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
11.11Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/&β;1/&γ;2
11.11Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
11.11Single8PWNTheophylline8PWN-A2A-Theophylline
11.11Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.11Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.11Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
11.11Consensuscyslt2_offOrthosteric Ligand6RZ6-CysLT2-ONO-2570366 6RZ9-CysLT2-ONO-2770372 6RZ8-CysLT2-ONO-2080365
11.11Consensuscyslt_offOrthosteric Ligandcyslt2_off
11.11Consensusep2_onOrthosteric Ligand7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
11.11Consensusep4_onOrthosteric Ligand7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2
11.11Consensusffa4_on_alloOrthosteric Ligand8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.11Consensusot_onOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
10.81Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
10.71Single3NY9PubChem 9131033NY9-β2-PubChem 913103
10.71Single5EE7MK08935EE7-Glucagon-MK0893
10.71Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
10.71Single7SK9CCX6627SK9-ACKR3-CCX662
10.71Single8SAI1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
10.71Consensusgo_vasopressinOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
10.53Single3RFMCaffeine3RFM-A2A-Caffeine
10.53Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
10.53Single6TQ9SB-4081246TQ9-OX1-SB-408124
10.53Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
10.53Single7VDMSubstance P7VDM-MRGPRX2-Substance P-Gi1/&β;1/&γ;2
10.53Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/&β;1/&γ;2
10.53Consensushca2_on_alloOrthosteric Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
10.34Single4AMJ(S)-Carvedilol4AMJ-β1-(S)-Carvedilol
10.34Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
10.34Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
10.34Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
10.26Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
10.00Single6HLOAprepitant6HLO-NK1-Aprepitant
10.00Single6ME9Ramelteon6ME9-MT2-Ramelteon
10.00Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
10.00Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2
10.00Single7MT9All-trans-retinal7MT9-Rhodopsin-All-trans-retinal-GRK1
10.00Single7MTAAll-trans-retinal7MTA-Rhodopsin-All-trans-retinal-GRK1
10.00Single7S8O(R)-Zinc-35737S8O-MRGPRX2-(R)-Zinc-3573-Gi1/&β;1/&γ;2
10.00Single8F76-8F76-OR51E2-Gs/&β;1/&γ;2
10.00Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
10.00Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
9.76Single8F2APramlintide analogue san3858F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
9.68Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
9.52Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
9.52Single5L7IVismodegib5L7I-SMO-Vismodegib
9.52Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
9.52Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
9.52Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
9.52Single7S8N(R)-Zinc-35737S8N-MRGPRX2-(R)-Zinc-3573-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.52Single7XKFBetahydroxyandrosterone7XKF-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
9.52Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/&β;1/&γ;2
9.52Single8GGCEpinephrine8GGC-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
9.52Single8GGEEpinephrine8GGE-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
9.52Single8GH1Epinephrine8GH1-β2-Epinephrine
9.52Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
9.52Consensusgo_adhesionOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
9.52Consensusgo_class-b2Orthosteric Ligandgo_adhesion
9.52Consensusmt1_onOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
9.52Consensusmt2_onOrthosteric Ligand7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
9.52Consensussmo_on_alloOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
9.38Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
9.38Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
9.38Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.38Consensusclass-d_onOrthosteric Ligandste2_on
9.38Consensusgi_class-dOrthosteric Ligandgi_ste
9.38Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
9.30Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
9.09Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
9.09Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
9.09Single4S0VSuvorexant4S0V-OX2-Suvorexant
9.09Single5DHHSB-6121115DHH-NOP-SB-612111
9.09Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
9.09Single5WS3EMPA5WS3-OX2-EMPA
9.09Single6AKYMaraviroc6AKY-CCR5-Maraviroc
9.09Single6B73PubChem 1319551386B73-κ-PubChem 131955138
9.09Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/&β;1/&γ;2
9.09Single6ME2Ramelteon6ME2-MT1-Ramelteon
9.09Single6OYAAll-trans-retinal6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
9.09Single6TPJSuvorexant6TPJ-OX2-Suvorexant
9.09Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
9.09Single7BR3Elagolix7BR3-GnRH1-Elagolix
9.09Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
9.09Single7F8ULintitript7F8U-CCKA-Lintitript
9.09Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
9.09Single7TUZ7alpha,25-dihydroxycholesterol7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
9.09Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
9.09Single8EFOPZM218EFO-μ-PZM21-Gi1/&β;1/&γ;2
9.09Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/&β;1/&γ;2
9.09Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.09Single8UO1Epinephrine8UO1-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
9.09Single8UO3Epinephrine8UO3-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
9.09Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
9.09Consensusclass-f_offOrthosteric Ligandsmo_off
9.09Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
9.09Consensusgi_nucleotideOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
9.09Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
9.09Consensusgt_class-aOrthosteric Ligandgt_opsin
9.09Consensusgt_opsinOrthosteric Ligandgt_sensory
9.09Consensusgt_sensoryOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
9.09Consensusmelatonin_onOrthosteric Ligandmt1_on mt2_on
9.09Consensusorexin_offOrthosteric Ligandox2_off ox1_off
9.09Consensussmo_on_alloOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
8.70Single2YDOAdenosine2YDO-A2A-Adenosine
8.70Single3UZCPubChem 1355666093UZC-A2A-PubChem 135566609
8.70Single4MBSMaraviroc4MBS-CCR5-Maraviroc
8.70Single4ZJCSB-6740424ZJC-OX1-SB-674042
8.70Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
8.70Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
8.70Single6TP3Nemorexant6TP3-OX1-Nemorexant
8.70Single6TPGEMPA6TPG-OX2-EMPA
8.70Single6TPKRetosiban6TPK-OT-Retosiban
8.70Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
8.70Single7JOZVFP7JOZ-D1-VFP-Gs/&β;1/&γ;2
8.70Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
8.70Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
8.70Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
8.70Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
8.70Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.70Single8F0JPramlintide analogue san458F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2
8.70Single8GCML9026888GCM-EP4-L902688-Gi1/&β;1/&γ;2
8.70Single8GDZEpinephrine8GDZ-β2-Epinephrine-Gs/&β;1/&γ;2
8.70Single8GG8Epinephrine8GG8-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
8.70Single8GGTEpinephrine8GGT-β2-Epinephrine
8.70Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.70Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2
8.70Single8HQN9(S)-HODE8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
8.70Single8K4NVF08K4N-GPR34-VF0-Gi1/&β;1/&γ;2
8.70Single8T3VDHA8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.70Single8UHBRO52563908UHB-TA1-RO5256390-Gs/&β;1/&γ;2
8.70Single8UO2Epinephrine8UO2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
8.70Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/&β;1/&γ;2
8.70Consensusgi_melatoninOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
8.70Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
8.70Consensusox1_offOrthosteric Ligand6TOT-OX1-Lemborexant 6TP4-OX1-ACT-462206 6TP6-OX1-Filorexant 6V9S-OX1-GTPL11403 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ7-OX1-SB-334867 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant
8.70Consensusox2_offOrthosteric Ligand6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant
8.70Consensusvasopressin-ot_offOrthosteric Ligandot_off
8.33Single2Y02Carmoterol2Y02-β1-Carmoterol
8.33Single2Y04Salbutamol2Y04-β1-Salbutamol
8.33Single4QIMPubChem 249053754QIM-SMO-PubChem 24905375
8.33Single4QKXPubChem 762106284QKX-β2-PubChem 76210628
8.33Single4X1HNonyl Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
8.33Single5TGZAM65385TGZ-CB1-AM6538
8.33Single6DRXLisuride6DRX-5-HT2B-Lisuride
8.33Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
8.33Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
8.33Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
8.33Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
8.33Single6GPSMK08126GPS-CCR2-MK0812
8.33Single6PS1Timolol6PS1-β2-Timolol
8.33Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
8.33Single7CRHSKF839597CRH-D1-SKF83959-Gs/&β;1/&γ;2
8.33Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
8.33Single7LJCPubChem 867641037LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
8.33Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
8.33Single7SCGFH2107SCG-μ-FH210-Gi1/&β;1/&γ;2
8.33Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/&β;1/&γ;2
8.33Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
8.33Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
8.33Single7VKTLTB47VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
8.33Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
8.33Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
8.33Single8GEBEpinephrine8GEB-β2-Epinephrine-Gs/&β;1/&γ;2
8.33Single8GEHEpinephrine8GEH-β2-Epinephrine-Gs/&β;1/&γ;2
8.33Single8GGBEpinephrine8GGB-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
8.33Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
8.33Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
8.33Single8UNMEpinephrine8UNM-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
8.33Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
8.33Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
8.33Consensusblt_onOrthosteric Ligandblt1_on
8.33Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
8.33Consensusffa1_onOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.33Consensusffa_onOrthosteric Ligandffa4_on ffa1_on ffa2_on ffa3_on
8.33Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
8.33Consensusleuko_onOrthosteric Ligandblt_on
8.33Consensusp2y12_offOrthosteric Ligand4NTJ-P2Y12-AZD1283 7PP1-P2Y12-Selatogrel
8.11Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
8.11Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/&β;1/&γ;2; RAMP2
8.00Single2Y00Dobutamine2Y00-β1-Dobutamine
8.00Single2Y03Isoprenaline2Y03-β1-Isoprenaline
8.00Single4WW3All-trans-retinal4WW3-Rhodopsin-All-trans-retinal
8.00Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
8.00Single5C1MBU725C1M-μ-BU72
8.00Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
8.00Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
8.00Single6GPXMK08126GPX-CCR2-MK0812
8.00Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
8.00Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
8.00Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
8.00Single6TP6Filorexant6TP6-OX1-Filorexant
8.00Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
8.00Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
8.00Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
8.00Single7SBFPZM217SBF-μ-PZM21-Gi1/&β;1/&γ;2
8.00Single7SINNPS-21437SIN-CaS-NPS-2143
8.00Single7SINNPS-21437SIN-CaS-NPS-2143
8.00Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
8.00Single7XKAEpinephrine7XKA-β2-Epinephrine
8.00Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
8.00Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
8.00Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
8.00Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2
8.00Single8GDCPGE28GDC-EP3-PGE2-Gi1/&β;1/&γ;2
8.00Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
8.00Single8J19PubChem 1270454228J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
8.00Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
8.00Single8UNYEpinephrine8UNY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
8.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.00Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide 6DRX-5-HT2B-Lisuride
8.00Consensusadrenergic_offOrthosteric Ligandbeta_off alpha_off
8.00Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
8.00Consensusccr2_off_alloOther Ligand5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
8.00Consensusep3_onOrthosteric Ligand8GDC-EP3-PGE2-Gi1/&β;1/&γ;2
8.00Consensusgs_adrenergicOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJI-β3-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
8.00Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
7.69Single2YDVNECA2YDV-A2A-NECA
7.69Single3P0GBI1671073P0G-β2-BI167107
7.69Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
7.69Single4DJHJDTic4DJH-κ-JDTic
7.69Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
7.69Single4UHRCGS216804UHR-A2A-CGS21680
7.69Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
7.69Single5G53NECA5G53-A2A-NECA-Gs
7.69Single6E59L-7607356E59-NK1-L-760735
7.69Single6H7JIsoprenaline6H7J-β1-Isoprenaline
7.69Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
7.69Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
7.69Single6TQ7SB-3348676TQ7-OX1-SB-334867
7.69Single6WGTLSD6WGT-5-HT2A-LSD
7.69Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2
7.69Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
7.69Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
7.69Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2
7.69Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/&β;1/&γ;2
7.69Single8G056-OAU8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
7.69Single8GDBPGE28GDB-EP4-PGE2-Gs/&β;1/&γ;2
7.69Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
7.69Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
7.69Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
7.69Consensus5ht5_offOrthosteric Ligand5ht5a_off
7.69Consensuscyslt1_off_ortoalloOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
7.69Consensusdopamine_offOrthosteric Ligandd3_off d2_off d4_off
7.69Consensusgs_ffaOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2 8GDB-EP4-PGE2-Gs/&β;1/&γ;2
7.69Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
7.69Consensusnk1_offOrthosteric Ligand6J20-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
7.50Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
7.41Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
7.41Single4AMIBucindolol4AMI-β1-Bucindolol
7.41Single4LDEBI1671074LDE-β2-BI167107
7.41Single4N4WSANT-14N4W-SMO-SANT-1
7.41Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
7.41Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
7.41Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
7.41Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
7.41Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
7.41Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
7.41Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
7.41Single8JJ8Formoterol8JJ8-β2-Formoterol
7.41Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
7.41Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
7.41Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg3_on
7.41Consensusbeta1_onOrthosteric Ligand7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
7.41Consensusclass-b2_onOrthosteric Ligandadgrg_on
7.41Consensusgi_class-fOther Ligandgi_frizzled
7.41Consensusgi_frizzledOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
7.41Consensusgo_5htOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
7.41Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
7.14Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
7.14Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
7.14Single6H7LDobutamine6H7L-β1-Dobutamine
7.14Single7CX2PGE27CX2-EP2-PGE2-Gs/&β;1/&γ;2
7.14Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
7.14Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
7.14Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
7.14Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
7.14Single7UM4AS26747237UM4-5-HT5A-AS2674723
7.14Single8ID8TUG-8918ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
7.14Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.14Consensus5ht5a_offOrthosteric Ligand7UM4-5-HT5A-AS2674723
7.14Consensusbeta1_off_alloOrthosteric Ligand4BVN-β1-Cyanopindolol-Na
7.14Consensusgs_lipidOrthosteric Ligandgs_ffa gs_prostanoid
7.14Consensusgs_prostanoidOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.90Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
6.90Single8X5YAstemizole8X5Y-H1-Astemizole
6.90Consensusgs_adgrOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
6.90Consensusgs_class-b2Orthosteric Ligandgs_adgr
6.67Single8F2BPramlintide analogue san458F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
6.25Single8W8SAA-148W8S-GPR101-AA-14
6.06Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
5.88Single8HS2Fab0468HS2-GPR20-Fab046
5.88Single8W8RAA-148W8R-GPR101-AA-14-chim(NtGi1-Gs)/&β;1/&γ;2
5.56Single5MZPCaffeine5MZP-A2A-Caffeine-Na
5.56Single8WCBCyclohexylammonium ion8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.56Single8WCCCyclohexylammonium ion8WCC-TA1-Cyclohexylammonium ion
5.26Single7TYIAmylin7TYI-CT-Amylin-Gs/&β;1/&γ;2
5.26Single7WC4Serotonin7WC4-5-HT2A-Serotonin
5.26Single7XKEBetahydroxyandrosterone7XKE-ADGRG2-Betahydroxyandrosterone-chim(NtGi1-Gs)/&β;1/&γ;2
5.26Single8GEJEpinephrine8GEJ-β2-Epinephrine-Gs/&β;1/&γ;2
5.26Single8HSCFab0468HSC-GPR20-Fab046-Gi1/&β;1/&γ;2
5.26Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
5.00Single7MTBAll-trans-retinal7MTB-Rhodopsin-All-trans-retinal-GRK1
5.00Single7XKDBetahydroxyandrosterone7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
5.00Single8F0KPramlintide analogue san3858F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
5.00Consensussensory_onOrthosteric Ligandopsin_on
4.76Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
4.76Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
4.76Single3UZAGTPL92363UZA-A2A-GTPL9236
4.76Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
4.76Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
4.76Single6FUFAll-trans-retinal6FUF-Rhodopsin-All-trans-retinal-Go/&β;1/&γ;2
4.76Single6LI0GTPL98046LI0-GPR52-GTPL9804
4.76Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/&β;1/&γ;2
4.76Single7MT8All-trans-retinal7MT8-Rhodopsin-All-trans-retinal-GRK1
4.76Single7WC5Psilocin7WC5-5-HT2A-Psilocin
4.76Single8EITDoconexent8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
4.76Single8GGREpinephrine8GGR-β2-Epinephrine
4.76Single8GGZEpinephrine8GGZ-β2-Epinephrine
4.76Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/&β;1/&γ;2
4.76Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
4.76Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/&β;1/&γ;2
4.76Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
4.76Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
4.76Consensusopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
4.76Consensussmo_off_alloOrthosteric Ligand6D32-SMO-Cyclopamine-Cyclopamine
4.55Single3AYMAll-trans-retinal3AYM-Rhodopsin-All-trans-retinal
4.55Single3PBLEticlopride3PBL-D3-Eticlopride
4.55Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
4.55Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
4.55Single6HLLCP999946HLL-NK1-CP99994
4.55Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
4.55Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
4.55Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
4.55Single6QNOAll-trans-retinal6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
4.55Single6TP4ACT-4622066TP4-OX1-ACT-462206
4.55Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
4.55Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2
4.55Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/&β;1/&γ;2
4.55Single8EF6Morphine8EF6-μ-Morphine-Gi1/&β;1/&γ;2
4.55Single8GEIEpinephrine8GEI-β2-Epinephrine-Gs/&β;1/&γ;2
4.55Single8GGSEpinephrine8GGS-β2-Epinephrine
4.55Single8GGYEpinephrine8GGY-β2-Epinephrine
4.55Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
4.55Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
4.55Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
4.55Single8UNVEpinephrine8UNV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
4.55Single8UNXEpinephrine8UNX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
4.55Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
4.55Single8X2K5YM8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
4.55Consensus5ht4_onOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
4.55Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
4.55Consensusox1_off_alloOrthosteric Ligand6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na 6TO7-OX1-Suvorexant-Na
4.35Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
4.35Single5U09Taranabant5U09-CB1-Taranabant
4.35Single6AKXA4R6AKX-CCR5-A4R
4.35Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
4.35Single6KUXRS-799486KUX-α2a-RS-79948
4.35Single6OBA(S)-Alprenolol6OBA-β2-(S)-Alprenolol-GTPL11074
4.35Single6TODEMPA6TOD-OX1-EMPA-Na
4.35Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
4.35Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2
4.35Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
4.35Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
4.35Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
4.35Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
4.35Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
4.35Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
4.35Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
4.35Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
4.35Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
4.35Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2
4.35Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2
4.35Single8GEAEpinephrine8GEA-β2-Epinephrine-Gs/&β;1/&γ;2
4.35Single8GECEpinephrine8GEC-β2-Epinephrine-Gs/&β;1/&γ;2
4.35Single8GEDEpinephrine8GED-β2-Epinephrine-Gs/&β;1/&γ;2
4.35Single8GEFEpinephrine8GEF-β2-Epinephrine-Gs/&β;1/&γ;2
4.35Single8GG7Epinephrine8GG7-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
4.35Single8GG9Epinephrine8GG9-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
4.35Single8GGAEpinephrine8GGA-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
4.35Single8GGFEpinephrine8GGF-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
4.35Single8GGVEpinephrine8GGV-β2-Epinephrine
4.35Single8GGWEpinephrine8GGW-β2-Epinephrine
4.35Single8GGXEpinephrine8GGX-β2-Epinephrine
4.35Single8GH0Epinephrine8GH0-β2-Epinephrine
4.35Single8HMPPubChem 699214798HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
4.35Single8IW4Spermidine8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2
4.35Single8IWESpermidine8IWE-TAAR9-Spermidine
4.35Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
4.35Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
4.35Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
4.35Single8U8FPML8U8F-GPR3-PML-Gs/&β;1/&γ;2
4.35Single8UNLEpinephrine8UNL-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
4.35Single8UNOEpinephrine8UNO-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
4.35Single8UNTEpinephrine8UNT-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
4.35Single8UNUEpinephrine8UNU-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
4.35Single8UNWEpinephrine8UNW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
4.35Single8UO0Epinephrine8UO0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
4.35Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
4.35Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
4.35Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
4.35Consensusalpha2_offOrthosteric Ligandalpha2a_off alpha2c_off
4.35Consensusalpha2a_offOrthosteric Ligand6KUX-α2a-RS-79948
4.35Consensusbeta2_off_alloOrthosteric Ligand6OBA-β2-(S)-Alprenolol-GTPL11074
4.35Consensusffa3_on_alloOrthosteric Ligand8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
4.35Consensusmglu_onOther Ligandmglu2_on mglu4_on
4.17Single4DKLBeta-funaltrexamine4DKL-μ-Beta-funaltrexamine
4.17Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
4.17Single6A94Zotepine6A94-5-HT2A-Zotepine
4.17Single6DS0Ly2660976DS0-5-HT2B-Ly266097
4.17Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
4.17Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
4.17Single6PS4ICI 118-5516PS4-β2-ICI 118-551
4.17Single6PS5(S)-Propranolol6PS5-β2-(S)-Propranolol
4.17Single6TPNHTL66416TPN-OX2-HTL6641
4.17Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
4.17Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/&β;1/&γ;2
4.17Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
4.17Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
4.17Single7F0TDopamine7F0T-D1-Dopamine-Gs/&β;1/&γ;2
4.17Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/&β;1/&γ;2
4.17Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.17Single7VODCariprazine7VOD-5-HT2A-Cariprazine
4.17Single7VVOPTH7VVO-PTH1-PTH-Gs/&β;1/&γ;2
4.17Single8GE1Epinephrine8GE1-β2-Epinephrine-Gs/&β;1/&γ;2
4.17Single8GE4Epinephrine8GE4-β2-Epinephrine-Gs/&β;1/&γ;2
4.17Single8GE6Epinephrine8GE6-β2-Epinephrine-Gs/&β;1/&γ;2
4.17Single8GE7Epinephrine8GE7-β2-Epinephrine-Gs/&β;1/&γ;2
4.17Single8GE8Epinephrine8GE8-β2-Epinephrine-Gs/&β;1/&γ;2
4.17Single8GE9Epinephrine8GE9-β2-Epinephrine-Gs/&β;1/&γ;2
4.17Single8GEGEpinephrine8GEG-β2-Epinephrine-Gs/&β;1/&γ;2
4.17Single8GFVEpinephrine8GFV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
4.17Single8GG3Epinephrine8GG3-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
4.17Single8GG4Epinephrine8GG4-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
4.17Single8GG5Epinephrine8GG5-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
4.17Single8GGIEpinephrine8GGI-β2-Epinephrine
4.17Single8GGKEpinephrine8GGK-β2-Epinephrine
4.17Single8GGLEpinephrine8GGL-β2-Epinephrine
4.17Single8GGMEpinephrine8GGM-β2-Epinephrine
4.17Single8GGPEpinephrine8GGP-β2-Epinephrine
4.17Single8GGQEpinephrine8GGQ-β2-Epinephrine
4.17Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.17Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
4.17Single8JLNT1AM8JLN-TA1-T1AM-Gs/&β;1/&γ;2
4.17Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2
4.17Single8UNQEpinephrine8UNQ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
4.17Single8UNREpinephrine8UNR-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
4.17Single8UNSEpinephrine8UNS-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
4.17Single8UNZEpinephrine8UNZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
4.17Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
4.17Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
4.17Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/&β;1/&γ;2
4.17Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.17Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6WH4-5-HT2A-Methiothepin 7VOE-5-HT2A-Aripiprazole 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 6A93-5-HT2A-Risperidone
4.17Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
4.17Consensusd1_on_alloOrthosteric Ligand7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
4.17Consensusgs_tarOrthosteric Ligand8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
4.17Consensussensory_offOrthosteric Ligandopsin_off
4.00Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
4.00Single2Y01Dobutamine2Y01-β1-Dobutamine
4.00Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
4.00Single3NY8ICI 118-5513NY8-β2-ICI 118-551
4.00Single3NYA(S)-Alprenolol3NYA-β2-(S)-Alprenolol
4.00Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
4.00Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
4.00Single4GBR(S)-Carazolol4GBR-β2-(S)-Carazolol
4.00Single5JQH(S)-Carazolol5JQH-β2-(S)-Carazolol
4.00Single6H7MSalbutamol6H7M-β1-Salbutamol
4.00Single6PRZ(S)-Alprenolol6PRZ-β2-(S)-Alprenolol
4.00Single6PS0(S)-Carazolol6PS0-β2-(S)-Carazolol
4.00Single6PS2(S)-Alprenolol6PS2-β2-(S)-Alprenolol
4.00Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
4.00Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
4.00Single7BU7BI1671077BU7-β1-BI167107
4.00Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
4.00Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
4.00Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
4.00Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
4.00Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
4.00Single7T2GMitragynine pseudoindoxyl7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
4.00Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2
4.00Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
4.00Single7WC7Lisuride7WC7-5-HT2A-Lisuride
4.00Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
4.00Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
4.00Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
4.00Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
4.00Single8GE3Epinephrine8GE3-β2-Epinephrine-Gs/&β;1/&γ;2
4.00Single8GEEEpinephrine8GEE-β2-Epinephrine-Gs/&β;1/&γ;2
4.00Single8GFWEpinephrine8GFW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
4.00Single8GFXEpinephrine8GFX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
4.00Single8GFYEpinephrine8GFY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
4.00Single8GFZEpinephrine8GFZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
4.00Single8GG0Epinephrine8GG0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
4.00Single8GG1Epinephrine8GG1-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
4.00Single8GG2Epinephrine8GG2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
4.00Single8GG6Epinephrine8GG6-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
4.00Single8GGJEpinephrine8GGJ-β2-Epinephrine
4.00Single8GGNEpinephrine8GGN-β2-Epinephrine
4.00Single8GGOEpinephrine8GGO-β2-Epinephrine
4.00Single8GGUEpinephrine8GGU-β2-Epinephrine
4.00Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2
4.00Single8J18(3R)-3-hydroxydodecanoic acid8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
4.00Single8JJOAlprenolol8JJO-β2-Alprenolol
4.00Single8JLZST19368JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
4.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
4.00Single8UNNEpinephrine8UNN-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
4.00Single8UNPEpinephrine8UNP-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
4.00Single8UO4Epinephrine8UO4-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
4.00Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
4.00Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-alpha-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
4.00Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
4.00Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
4.00Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
4.00Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
4.00Consensusadrenergic_onOrthosteric Ligandbeta_on alpha_on
4.00Consensusamine_onOrthosteric Ligandadrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on
4.00Consensusdopamine_onOrthosteric Ligandd3_on d2_on d5_on d1_on
4.00Consensusgi_5htOrthosteric Ligand7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
4.00Consensustachykinin_offOrthosteric Ligandnk1_off
4.00Consensustar_onOrthosteric Ligandta1_on
3.85Single2RH1(S)-Carazolol2RH1-β2-(S)-Carazolol
3.85Single2YCW(S)-Carazolol2YCW-β1-(S)-Carazolol
3.85Single4NTJAZD12834NTJ-P2Y12-AZD1283
3.85Single5D6L(S)-Carazolol5D6L-β2-(S)-Carazolol
3.85Single5TVNLSD5TVN-5-HT2B-LSD
3.85Single5X7D(S)-Carazolol5X7D-β2-(S)-Carazolol-PubChem 129318963
3.85Single5XPRBosentan5XPR-ETB-Bosentan
3.85Single5ZK3Quinuclidinyl benzilate hydrobromide5ZK3-M2-Quinuclidinyl benzilate hydrobromide
3.85Single6E67BI1671076E67-β2-BI167107-Gs (fused)
3.85Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
3.85Single6PS3(S)-Carvedilol6PS3-β2-(S)-Carvedilol
3.85Single6PS6Timolol6PS6-β2-Timolol
3.85Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
3.85Single7BVQ(S)-Carazolol7BVQ-β1-(S)-Carazolol
3.85Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
3.85Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2
3.85Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
3.85Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
3.85Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
3.85Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
3.85Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
3.85Consensusamine_offOrthosteric Ligandadrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
3.85Consensusbeta2_offOrthosteric Ligand6PS2-β2-(S)-Alprenolol 6PS3-β2-(S)-Carvedilol 6PS5-β2-(S)-Propranolol 6PS6-β2-Timolol 2RH1-β2-(S)-Carazolol 6PS4-β2-ICI 118-551 3NY9-β2-PubChem 913103
3.85Consensusbeta2_onOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
3.85Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
3.85Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
3.85Consensusgi_adrenergicOrthosteric Ligand7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
3.70Single3UONQuinuclidinyl benzilate hydrobromide3UON-M2-Quinuclidinyl benzilate hydrobromide
3.70Single5D5A(S)-Carazolol5D5A-β2-(S)-Carazolol
3.70Single5D5B(S)-Carazolol5D5B-β2-(S)-Carazolol
3.70Single5V54Methiothepin5V54-5-HT1B-Methiothepin
3.70Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
3.70Single7W6PW967W6P-α2a-W96-Go/&β;1/&γ;2
3.70Single7W7EW587W7E-α2a-W58-Go/&β;1/&γ;2
3.70Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/&β;1/&γ;2
3.70Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
3.70Single8JXVClozapine8JXV-H4-Clozapine-Gi1/&β;1/&γ;2
3.70Single8JXWVUF68848JXW-H4-VUF6884-Gi1/&β;1/&γ;2
3.70Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.70Single8X79MRE-2698X79-I2-MRE-269-Gs/&β;1/&γ;2
3.70Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
3.70Consensus5ht1_offOrthosteric Ligand5ht1b_off
3.70Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
3.70Consensus5ht_offOrthosteric Ligand5ht2_off 5ht5_off 5ht1_off
3.70Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCZ-β1-Iodocyanopindolol
3.70Consensusgi_amineOrthosteric Ligandgi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
3.70Consensusmglu2_onOther Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
3.57Single3D4STimolol Maleate3D4S-β2-Timolol Maleate
3.57Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
3.57Single6CM4Risperidone6CM4-D2-Risperidone
3.57Single6H7N(S)-Xamoterol6H7N-β1-(S)-Xamoterol
3.57Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
3.57Single6HLPNetupitant6HLP-NK1-Netupitant
3.57Consensusprostanoid_onOrthosteric Ligandep_on fpa_on
3.45Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
3.45Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
3.45Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
3.45Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
3.45Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.45Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
3.45Consensusfpa_onOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.33Single6PT3DPI-2876PT3-δ-DPI-287
3.33Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.33Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2

Consensus Members
Id Members
7WQ4 7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7XJL 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
Net Summary
Imin 2.655
Number of Linked Nodes 872
Number of Links 1072
Number of Hubs 179
Number of Links mediated by Hubs 657
Number of Communities 25
Number of Nodes involved in Communities 227
Number of Links involved in Communities 340
Path Summary
Number Of Nodes in MetaPath 82
Number Of Links MetaPath 81
Number of Shortest Paths 1046959
Length Of Smallest Path 3
Average Path Length 33.0904
Length of Longest Path 66
Minimum Path Strength 0.6875
Average Path Strength 5.8644
Maximum Path Strength 19.2475
Minimum Path Correlation 0.7
Average Path Correlation 0.977542
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.72414
Average % Of Corr. Nodes 38.8781
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 51.1404
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following consensuses:
IdComponents
gs_peptidegs_cck
gs_motilin
gs_neuromedin
gs_orexin
gs_sst
gs_tachykinin
gs_trh
gs_vasopressin-ot
gs_bombesin
gs_bradykinin
gs_compl-peptide
gs_endothelin
gs_galanin
gs_ghrelin
gs_melanocortin



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