Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
1G.hns1.01 6.746504
2G.S1.02 7.54254136
3G.s1h1.04 7.4475409
4G.H1.01 5.39254179
5G.hfs2.07 3.0875428
6G.S3.01 5.86754135
7G.S3.03 9.1925138
8G.S3.05 4.79408
9G.S3.06 8.99527
10G.s3h2.03 5.528529
11G.H2.06 7.066529
12G.H2.07 5.894529
13G.h2s4.01 7.20333629
14G.h2s4.02 6.015488
15G.S4.04 6.39509
16G.S4.06 5.35567
17G.H3.09 5.66669
18G.H3.13 9.895606
19G.H3.17 9.365685
20G.S5.04 4.9375469
21G.S5.05 5.0125109
22G.S5.06 5.3475468
23G.S5.07 4.5575409
24G.hgh4.02 5.2725408
25G.hgh4.21 3.99404
26G.H4.03 4.535404
27G.H4.08 6.95563
28G.H4.10 7.022507
29G.H4.15 6.63468
30G.h4s6.10 8.3375403
31G.S6.02 8.525408
32G.S6.05 12.075465
33G.s6h5.05 11.2454109
34G.H5.06 8.3245104
35G.H5.08 5.856676138
36G.H5.14 4.9575406
37G.H5.23 11.6675404
38b.1x4 4.16408
39b.1x11 6.215408
40b.lh12x2 6.15408
41b.lhb1x6 3.984503
42b.lhb1x9 5.04754143
43b.b1x3 6.624157
44b.l1x3 7.516676129
45b.l1x6 10.276589
46b.b2x3 11.94754126
47b.b2x5 6.865607
48b.b3x3 6.1275498
49b.l3x2 8.5425409
50b.b4x3 6.3325497
51b.b4x5 5.025697
52b.b4x6 10.57577129
53b.b5x2 6.285407
54b.b5x3 7.8225129
55b.b5x7 5.748597
56b.l5x1 5.45254218
57b.l5x5 10.2617629
58b.b6x5 4.8625896
59b.l6x5 6.484164
60b.b7x1 5.1725164
61b.b7x2 4.398598
62b.l7x4 4.585429
63b.b8x3 5.495406
64b.b8x4 6.765406
65b.l9x3 7.252579
66b.l9x6 6.535628
67b.b10x3 3.8275478
68b.b10x5 6.342509
69b.l10x3 6.794166
70b.b11x2 5.6925477
71b.b11x4 5.14667679
72b.b11x5 4.82446
73b.l11x2 8.1525479
74b.b12x2 5.6225477
75b.b12x3 4.016548
76b.b12x6 10.0933678
77b.b13x3 6.6875474
78b.b13x7 6.29667647
79b.l13x3 9.48549
80b.l13x6 6.7175429
81b.l13x7 5.838549
82b.b14x3 4.5575445
83b.b15x1 8.258549
84b.b15x2 6.3125456
85b.b15x3 4.6075449
86b.l15x2 6.325449
87b.b16x4 10.975446
88b.b16x5 5.708555
89b.b16x6 9.068548
90b.b17x4 5.776555
91b.b17x5 6.825457
92b.l17x3 7.205659
93b.l17x6 10.8975429
94b.b18x3 6.174558
95b.l18x1 7.10833636
96b.l18x2 6.03437
97b.b19x2 7.17667656
98b.b19x4 6.122558
99b.b20x4 8.196558
100b.b20x6 9.602556
101b.b20x7 6.2354229
102b.l20x2 9.985409
103b.b21x7 7.21435
104b.b22x3 4.095436
105b.b23x2 4.51667636
106b.b23x6 5.73667637
107b.l23x1 6.666586
108b.b24x4 6.11436
109b.b24x5 5.28754145
110b.b24x6 6.598538
111b.b25x3 5.814535
112b.l25x3 13.1275409
113b.l25x6 15.038588
114b.b26x3 6.1465146
115b.l28x1 13.256589
116b.b28x2 5.8975404
117b.b28x3 9.18754127
118b.b28x6 13.1475409
119b.b28x7 7.48754159
120g.h1x11 3.0975409
121g.l1x4 5.705408
122g.h2x11 7.7525436
123g.ctx3 7.7525409
124g.ctx14 6.8085159
125g.ctx16 4.278158
1261x39 4.293336116
127I1 8.64667607
1282x42 5.61286708
1292x43 3.875418
1302x45 6.57408
1312x46 4.66419
1322x50 6.942509
1332x57 4.398336119
1342x64 4.5085117
135E1x50 6.594519
136E1x52 7.7375417
1373x28 7.5075418
1383x35 5.894519
1393x36 4.92419
1403x43 5.396518
1413x46 4.2725419
1423x49 10.28754189
1433x50 8.344519
144I2x57 7.0825189
1454x50 4.825409
1464x64 6.17518
1474x65 9.2425408
148E2 23.4213814
149E2x52 13.2175417
1505x43 7.81419
1515x47 6.994519
1525x50 4.8525409
1535x54 6.2775418
1545x58 4.90857719
1555x62 3.1075406
1566x44 6.688519
1576x48 6.6825819
1586x51 9.2519
1596x54 5.96414
1607x30 5.2375417
1617x34 7.155418
1627x53 5.00286719
163Lig 14.95071510
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1b.b3x6 b.l1x3 52.672511.16NoYes099
2b.b3x6 b.l3x2 52.911410.31NoYes099
3b.b4x6 b.l1x3 38.41374.23YesYes1299
4b.l1x4 b.l3x2 79.149612.21NoYes069
53x50 G.H5.25 97.63916.07YesNo098
66x33 G.H5.25 97.95065.9NoNo078
75x65 6x33 98.106212.04NoNo077
85x65 G.H5.26 98.72823.04NoNo078
9G.H5.21 G.H5.26 98.88363.92NoNo048
10G.H5.21 G.h4s6.12 99.03843.2NoNo042
11G.h4s6.10 G.h4s6.12 99.349219.06YesNo032
12G.h4s6.08 G.h4s6.10 49.83848.83NoYes053
13G.H3.13 G.h4s6.08 49.97597.41YesNo065
14G.H3.09 G.H3.13 1007.02YesYes096
15G.H3.09 G.S4.04 97.73987.5YesYes099
16G.H3.08 G.S4.04 62.92834.78NoYes089
17G.H2.04 G.H3.08 62.940411.91NoNo098
18G.H2.04 G.H2.07 62.96594NoYes099
19G.H2.07 G.h2s4.01 42.76194.01YesYes299
20G.S3.06 G.h2s4.01 27.42814.29YesYes279
21G.S1.03 G.S3.06 26.6183.21NoYes097
22G.S1.03 G.hns1.01 52.975214.4NoYes094
23G.hns1.01 b.l1x4 79.88243.52YesNo046
24G.h4s6.10 G.h4s6.13 49.8213.78YesNo037
25G.H3.13 G.h4s6.13 49.889823.27YesNo067
26G.H3.12 G.S4.04 40.81168.79NoYes089
27G.H3.12 G.S1.07 40.81747.14NoNo088
28G.S1.05 G.S1.07 40.83588.3NoNo098
29G.S1.05 G.h2s4.01 40.964113.4NoYes099
30G.h2s4.01 G.h2s4.04 26.57782.62YesNo099
31G.S1.03 G.h2s4.04 26.50412.62NoNo099
32G.h2s4.01 b.l5x5 29.305414.03YesYes299
33b.l3x1 b.l5x5 29.314114.24NoYes099
34G.hns1.01 b.l3x1 27.7085.64YesNo049
353x50 G.H5.23 33.533321.61YesYes094
363x49 G.H5.23 33.354210.34YesYes094
373x49 3x53 33.97624.38YesNo1895
383x53 G.H5.19 33.81095.91NoNo058
39G.H5.15 G.H5.19 33.61954.25NoNo088
40G.H5.15 I2x54 33.4284.12NoNo089
41G.S1.02 I2x54 17.11253.99YesNo069
42G.S1.02 G.S3.03 14.16779.74YesYes1368
43G.S3.01 I2x54 16.12998.6YesNo059
44G.S3.01 G.S3.03 14.18577.87YesYes1358
45G.H1.01 G.S1.06 12.21735.64YesNo098
46G.S1.06 G.S3.05 12.6114.24NoYes088
47G.S2.06 G.S3.05 14.17916.22NoYes098
48G.S2.06 G.S3.03 27.565719.29NoYes098
49G.S5.07 G.s5hg.01 14.1942.8YesNo099
50G.H5.07 G.S2.06 12.99585.02NoNo099
51G.H5.07 G.S5.05 12.20915.02NoYes1099
52G.H5.06 G.S5.05 10.63913.21YesYes1049
53b.b4x1 b.l3x2 29.06153.35NoYes089
54b.b4x1 b.l5x1 28.80395.13NoYes088
55b.b8x4 b.l5x1 27.2475.86YesYes068
56b.b5x7 b.b8x4 24.67567.25YesYes076
57b.b5x7 b.b7x2 22.61383.07YesYes978
58b.b6x5 b.b7x2 20.32193.79YesYes968
59b.b2x4 b.b6x5 18.33153.27NoYes066
60b.b10x4 b.b2x4 18.079810.16NoNo066
61b.b10x4 b.b6x4 17.57842.77NoNo067
62b.b10x5 b.b6x4 17.3292.77YesNo097
63b.b10x5 b.b11x2 10.078611.3YesYes097
64G.H2.07 b.l9x6 24.06973.86YesYes298
65G.H2.06 b.l9x6 23.53053.58YesYes298
66G.H2.06 b.l17x6 23.318812.44YesYes299
673x50 7x53 36.18215.14YesYes199
681x50 2x50 12.69936.73NoYes099
692x46 2x50 14.00445.43YesYes099
702x46 7x53 14.31733.52YesYes199
71b.l17x6 b.l19x1 23.467919.96YesNo099
72b.b19x6 b.l19x1 23.3985.89NoNo099
73b.b19x6 b.l17x3 23.251212.55NoYes099
74b.b19x4 b.l17x3 15.3015.48YesYes589
75b.b17x5 b.b17x7 11.06797.03YesNo578
76b.l27x5 g.ctx15 12.32796.71NoNo059
77b.l27x5 g.ctx4 29.44435.03NoNo057
78g.ctx3 g.ctx4 25.92996.44YesNo097
79b.l22x1 g.ctx3 22.43358.83NoYes099
80b.b23x1 b.l22x1 20.12296.01NoNo059
81b.b23x1 b.lhb1x6 18.42064.47NoYes053
82b.b24x7 b.lhb1x6 15.32297.3NoYes093
83b.b1x6 b.b4x6 25.667833.03NoYes099
84b.b1x6 b.b28x5 24.9195.71NoNo095
85b.b2x3 b.b3x2 16.064319.79YesNo1265
86b.b2x5 b.b3x2 15.573411.39YesNo075
87b.b2x5 b.l27x1 21.151613.34YesNo077
88b.l27x3 b.l27x5 18.29484.16NoNo075
89b.b16x7 b.b17x4 15.17259.53NoYes095
90b.b16x7 b.l16x3 14.899710.39NoNo093
91b.b17x2 b.l16x3 14.6329.47NoNo033
92b.b17x2 g.h1x10 14.36555.44NoNo039
93g.h1x10 g.h1x14 13.83855.1NoNo099
946x51 Lig 26.059816.96YesYes190
956x48 6x51 26.78797.72YesYes199
966x44 6x48 31.40548.02YesYes199
973x43 6x44 22.13484.87YesYes189
983x43 7x53 23.01018.21YesYes189
995x54 6x44 20.78779.95YesYes189
1005x54 5x58 20.92464.79YesYes189
1013x50 5x58 26.40955.14YesYes199
102b.b28x5 g.ctx16 16.88713.77NoYes058
103b.l27x1 b.l27x3 18.98047.23NoNo2077
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
2x563x3210.841NoNo9821
2x563x354.471NoYes9922
2x593x2818.840NoYes8821
2x63E210.161NoYes7411
2x63Lig8.191NoYes7010
E1E1x494.931NoNo7622
E1E24.681NoYes7421
E1x49E233.131NoYes6421
3x28E1x503.521YesYes8912
3x22E216.371NoYes1421
3x283x293.391YesNo8811
3x28Lig4.281YesYes8010
3x294x6511.531NoYes8812
3x29Lig4.931NoYes8010
3x323x354.251NoYes8912
3x32Lig4.281NoYes8010
3x335x437.850NoYes5921
3x375x4314.971NoYes8921
3x376x485.011NoYes8922
3x376x515.161NoYes8921
4x64E2x5216.881YesYes8721
4x645x363.521YesNo8322
4x65E2x5218.520YesYes8721
E2Lig42.021YesYes4010
E2E238.051YesYes4411
E2E2x504.911YesNo4812
5x36E2x527.031NoYes3721
E2x52Lig10.441YesYes7010
5x436x513.091YesYes9911
5x43Lig5.331YesYes9010
6x486x517.721YesYes9921
6x516x5213.071YesNo9912
6x51Lig16.961YesYes9010
6x547x345.971YesYes4821
6x547x379.781YesNo4622
6x55Lig60NoYes8010
E3E34.791NoNo3311
E3Lig13.381NoYes3010
7x347x373.111YesNo8612
7x347x385.61YesNo8411
7x34Lig13.941YesYes8010
7x38Lig15.821NoYes4010
6x58Lig1.530NoYes2010

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
66.67Single5N2SPSB365N2S-A1-PSB36
61.11Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
58.82Single8I95EP548I95-C3aB-EP54-Go/&β;1/&γ;2
58.82Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2
57.14Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
56.25Single5N2RPubChem 92460631; psb365N2R-A2A-PubChem 92460631; psb36-Na
56.25Single8GNEKW-63568GNE-A2A-KW-6356-Na
56.25Single8ID9Eicosapentaenoic acid8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
52.94Single3SN6BI1671073SN6-β2-BI167107-Gs/&β;1/&γ;2
52.94Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
52.94Single6NI3BI1671076NI3-β2-BI167107-Gs/&β;1/&γ;2
52.94Single7JVPSKF839597JVP-D1-SKF83959-Gs/&β;1/&γ;2
52.63Single7XN9L-054,5227XN9-SST2-L-054,522
52.63Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2 8I95-C3aB-EP54-Go/&β;1/&γ;2
52.63Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
52.63Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
52.38Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
50.00Single7C61Ergotamine7C61-5-HT1B-Ergotamine
50.00Single7F8XNN90567F8X-CCKA-NN9056
50.00Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
50.00Single7Y24Octreotide7Y24-SST2-Octreotide-Go/&β;1/&γ;2
50.00Single8CU6LJ-45178CU6-A2A-LJ-4517
50.00Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2
50.00Single8JJLOlodaterol8JJL-β2-Olodaterol
50.00Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
50.00Consensusgo_5htOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
50.00Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
50.00Consensussst_onOrthosteric Ligandsst2_on sst4_on
48.00Single8FEGPRD_0025178FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
48.00Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
48.00Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
47.83Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
47.62Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
47.62Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
47.62Consensusalpha1_offOrthosteric Ligandalpha1a_off alpha1b_off
47.37Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
47.37Single6DDFDamgo6DDF-μ-Damgo-Gi1/&β;1/&γ;2
47.37Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
47.37Consensuscckb_onOrthosteric Ligand7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
47.37Consensusgs_orexinOrthosteric Ligand7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
47.37Consensusorexin_onOrthosteric Ligandox2_on
47.06Single7CFNINT-7777CFN-GPBA-INT-777-Gs/&β;1/&γ;2
47.06Single7CKXA776367CKX-D1-A77636-Gs/&β;1/&γ;2
47.06Single8DZQmomSalB8DZQ-κ-momSalB-Go/&β;1/&γ;2
47.06Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
47.06Consensusadrenergic_offOrthosteric Ligandbeta_off alpha_off
47.06Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRR-D1-Rotigotine-Gs/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
47.06Consensusgo_opioidOrthosteric Ligand8DZQ-κ-momSalB-Go/&β;1/&γ;2
46.67Single5K2DZM2413855K2D-A2A-ZM241385
46.67Single6JZHZM2413856JZH-A2A-ZM241385-Na
46.67Single6PS7ZM2413856PS7-A2A-ZM241385-Na
46.67Single7F8ULintitript7F8U-CCKA-Lintitript
46.67Single7XRRLemborexant7XRR-OX2-Lemborexant
46.67Single8GNGIstradefylline8GNG-A2A-Istradefylline
46.15Single8A2OTheophylline8A2O-A2A-Theophylline-Na
46.15Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
45.83Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
45.45Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
45.00Single4UG2CGS216804UG2-A2A-CGS21680
45.00Single5WF6UK-4320975WF6-A2A-UK-432097
45.00Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
45.00Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
45.00Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
45.00Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
45.00Consensuslpl_offOrthosteric Ligands1p_off lpa_off
44.44Single3P0GBI1671073P0G-β2-BI167107
44.44Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
44.44Single4RWADIPP-NH24RWA-δ-DIPP-NH2
44.44Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
44.44Single6H7JIsoprenaline6H7J-β1-Isoprenaline
44.44Single7CKYPW04647CKY-D1-PW0464-Gs/&β;1/&γ;2
44.44Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2
44.44Single7JV5SKF812977JV5-D1-SKF81297-Gs/&β;1/&γ;2
44.44Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
44.44Single7XOWGastrin7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
44.44Single7XOXCholecystokinin-87XOX-CCKB-Cholecystokinin-8-Gq/&β;1/&γ;2
44.44Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/&β;1/&γ;2
44.44Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
44.44Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
44.44Consensusa2_onOrthosteric Liganda2a_on a2b_on
44.44Consensusadenosine_offOrthosteric Liganda1_off a2_off
44.44Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
44.44Consensuscck_onOrthosteric Ligandccka_on cckb_on
44.44Consensusffa4_onOrthosteric Ligand8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
44.44Consensusgi_ffaOrthosteric Ligand8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
44.44Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2
44.44Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
44.44Consensuslpa_offOrthosteric Ligandlpa1_off
44.44Consensuslpa_onOrthosteric Ligandlpa1_on
43.75Single5IU4ZM2413855IU4-A2A-ZM241385-Na
43.75Single5IU7Q274563465IU7-A2A-Q27456346-Na
43.75Single5IUBQ274563445IUB-A2A-Q27456344-Na
43.75Single5JTBZM2413855JTB-A2A-ZM241385
43.75Single5K2BZM2413855K2B-A2A-ZM241385-Na
43.75Single5K2CZM2413855K2C-A2A-ZM241385-Na
43.75Single5NLXZM2413855NLX-A2A-ZM241385-Na
43.75Single5NM4ZM2413855NM4-A2A-ZM241385-Na
43.75Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
43.75Single7AROLUF58337ARO-A2A-LUF5833-Na
43.75Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
43.75Single8UO2Epinephrine8UO2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
43.48Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
43.48Consensusgi_somatostatinOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
42.86Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
42.86Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
42.86Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
42.86Single8G59TUG-8918G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
42.86Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
42.86Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
42.86Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
42.86Consensusmop_offOrthosteric Ligand7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
42.86Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
42.86Consensussst2_onOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
42.31Single6IGLIRL16206IGL-ETB-IRL1620
42.31Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
42.11Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
42.11Single4LDEBI1671074LDE-β2-BI167107
42.11Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
42.11Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
42.11Single6MXTSalmeterol6MXT-β2-Salmeterol
42.11Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
42.11Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
42.11Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2
42.11Single8J6DEP1418J6D-C3aB-EP141-Go/&β;1/&γ;2
42.11Single8JJ8Formoterol8JJ8-β2-Formoterol
42.11Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
41.67Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
41.67Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
41.67Consensusgs_melanocortinOrthosteric Ligand7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2
41.18Single2Y02Carmoterol2Y02-β1-Carmoterol
41.18Single2Y04Salbutamol2Y04-β1-Salbutamol
41.18Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
41.18Single3EMLZM2413853EML-A2A-ZM241385
41.18Single4EIYZM2413854EIY-A2A-ZM241385-Na
41.18Single4QKXPubChem 762106284QKX-β2-PubChem 76210628
41.18Single5IU8Q274563475IU8-A2A-Q27456347-Na
41.18Single5K2AZM2413855K2A-A2A-ZM241385-Na
41.18Single5OLGZM2413855OLG-A2A-ZM241385-Na
41.18Single5UENDU1725UEN-A1-DU172
41.18Single5VRAZM2413855VRA-A2A-ZM241385-Na
41.18Single6LPJZM2413856LPJ-A2A-ZM241385-Na
41.18Single6LPKZM2413856LPK-A2A-ZM241385-Na
41.18Single6PRZ(S)-Alprenolol6PRZ-β2-(S)-Alprenolol
41.18Single6S0LZM2413856S0L-A2A-ZM241385
41.18Single6TOTLemborexant6TOT-OX1-Lemborexant
41.18Single7BU7BI1671077BU7-β1-BI167107
41.18Single7CRHSKF839597CRH-D1-SKF83959-Gs/&β;1/&γ;2
41.18Single7PYRPSB-21157PYR-A2A-PSB-2115
41.18Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
41.18Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/&β;1/&γ;2
41.18Single7UL4Alvimopan7UL4-μ-Alvimopan
41.18Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
41.18Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
41.18Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
41.18Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
41.18Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
41.18Single8EFQDamgo8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
41.18Single8GEHEpinephrine8GEH-β2-Epinephrine-Gs/&β;1/&γ;2
41.18Single8UNMEpinephrine8UNM-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
41.18Consensusa2_offOrthosteric Liganda2a_off
41.18Consensusa2a_offOrthosteric Ligand8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 5UIG-A2A-J3.651.884G 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-PubChem 168451710 5K2D-A2A-ZM241385
41.18Consensusadenosine_onOrthosteric Liganda1_on a2_on
41.18Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
41.18Consensuscck_offOrthosteric Ligandccka_off
41.18Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
41.18Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
41.18Consensusnucleotide_onOrthosteric Ligandadenosine_on
40.91Single3QAKUK-4320973QAK-A2A-UK-432097
40.91Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
40.91Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
40.91Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
40.91Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
40.91Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
40.91Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
40.91Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
40.74Single5GLHEndothelin-15GLH-ETB-Endothelin-1
40.74Single6IGKEndothelin-36IGK-ETB-Endothelin-3
40.00Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
40.00Single3OE9IT1t3OE9-CXCR4-IT1t
40.00Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
40.00Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
40.00Single6H7LDobutamine6H7L-β1-Dobutamine
40.00Single6TP4ACT-4622066TP4-OX1-ACT-462206
40.00Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
40.00Single7EZCUKA7EZC-A2A-UKA
40.00Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2
40.00Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
40.00Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
40.00Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/&β;1/&γ;2
40.00Single7XJISolabegron7XJI-β3-Solabegron-Gs/&β;1/&γ;2
40.00Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
40.00Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
40.00Single8GH1Epinephrine8GH1-β2-Epinephrine
40.00Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
40.00Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
40.00Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
40.00Consensusbb1_onOrthosteric Ligand8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
40.00Consensusc5a1_off_ortoalloOrthosteric Ligand6C1Q-C5a1-PMX53-NDT9513727 6C1R-C5a1-PMX53-Avacopan; Na
40.00Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
40.00Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
40.00Consensusgi_neuromedinOrthosteric Ligand7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
40.00Consensusox1_off_alloOrthosteric Ligand6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na 6TO7-OX1-Suvorexant-Na
39.29Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
39.29Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
39.13Single5WF5UK-4320975WF5-A2A-UK-432097
39.13Single6PT2KGCHM076PT2-δ-KGCHM07
39.13Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1
39.13Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
39.13Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
39.13Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;2
39.13Consensusangiotensin_onOrthosteric Ligandat1_on
39.13Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
39.13Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
39.13Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
38.89Single2Y00Dobutamine2Y00-β1-Dobutamine
38.89Single2Y03Isoprenaline2Y03-β1-Isoprenaline
38.89Single5IUAQ274563485IUA-A2A-Q27456348-Na
38.89Single5NM2ZM2413855NM2-A2A-ZM241385-Na
38.89Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
38.89Single5TVNLSD5TVN-5-HT2B-LSD
38.89Single6DDEDamgo6DDE-μ-Damgo-Gi1/&β;1/&γ;2
38.89Single6E67BI1671076E67-β2-BI167107-Gs (fused)
38.89Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
38.89Single6LPLZM2413856LPL-A2A-ZM241385-Na
38.89Single6PS3(S)-Carvedilol6PS3-β2-(S)-Carvedilol
38.89Single6S0QZM2413856S0Q-A2A-ZM241385
38.89Single6TP6Filorexant6TP6-OX1-Filorexant
38.89Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
38.89Single6WQAZM2413856WQA-A2A-ZM241385-Na
38.89Single7BVQ(S)-Carazolol7BVQ-β1-(S)-Carazolol
38.89Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
38.89Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
38.89Single7RM5ZM2413857RM5-A2A-ZM241385-Na
38.89Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2
38.89Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
38.89Single7XKAEpinephrine7XKA-β2-Epinephrine
38.89Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
38.89Single7Y27Somatostatin-147Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
38.89Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
38.89Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
38.89Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
38.89Single8FN1Neurotensin/neuromedin N8FN1-NTS1-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
38.89Single8FYNZM2413858FYN-A2A-ZM241385-Na
38.89Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
38.89Single8QOTNanobody E8QOT-μ-Nanobody E
38.89Single8UNYEpinephrine8UNY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
38.89Consensusa1_on_alloOrthosteric Ligand7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
38.89Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
38.89Consensusbeta2_onOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
38.89Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
38.89Consensusgi_adrenergicOrthosteric Ligand7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
38.89Consensusgs_adrenergicOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJI-β3-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
38.89Consensusgs_sstOrthosteric Ligand7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
38.46Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
38.46Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
38.46Single8PWNTheophylline8PWN-A2A-Theophylline
38.46Consensusendothelin_onOrthosteric Ligandetb_on eta_on
38.10Single3NY9PubChem 9131033NY9-β2-PubChem 913103
38.10Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
38.10Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
38.10Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
38.10Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
38.10Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
38.10Consensusgs_bombesinOrthosteric Ligand8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
38.10Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
38.10Consensuslpl_onOrthosteric Ligands1p_on lpa_on
38.10Consensusmotilin_onOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
37.50Single2X72All-trans-retinal2X72-Rhodopsin-All-trans-retinal-Gt(CT)
37.50Single3PWHZM2413853PWH-A2A-ZM241385
37.50Single3VG9ZM2413853VG9-A2A-ZM241385-Antibody
37.50Single3VGAZM2413853VGA-A2A-ZM241385-Antibody
37.50Single5WS3EMPA5WS3-OX2-EMPA
37.50Single6KUXRS-799486KUX-α2a-RS-79948
37.50Single6OBA(S)-Alprenolol6OBA-β2-(S)-Alprenolol-GTPL11074
37.50Single6TODEMPA6TOD-OX1-EMPA-Na
37.50Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
37.50Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
37.50Single7F8YDevazepide7F8Y-CCKA-Devazepide
37.50Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
37.50Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
37.50Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
37.50Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
37.50Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
37.50Single8GEDEpinephrine8GED-β2-Epinephrine-Gs/&β;1/&γ;2
37.50Single8GG9Epinephrine8GG9-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
37.50Single8GGFEpinephrine8GGF-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
37.50Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
37.50Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
37.50Single8UNLEpinephrine8UNL-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
37.50Single8UNTEpinephrine8UNT-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
37.50Single8UNUEpinephrine8UNU-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
37.50Single8UNWEpinephrine8UNW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
37.50Single8UO0Epinephrine8UO0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
37.50Single8UO1Epinephrine8UO1-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
37.50Single8UO3Epinephrine8UO3-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
37.50Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
37.50Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
37.50Consensusa2a_off_alloOrthosteric Ligand6ZDR-A2A-HMS1413f12-Na 6GT3-A2A-Imaradenant-Na 8CU7-A2A-LJ-4517-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PubChem 92460631; psb36-Na 5MZJ-A2A-Theophylline-Na 5OLO-A2A-Tozadenant-Na 5OLH-A2A-Vipadenant-Na 5NM4-A2A-ZM241385-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5MZP-A2A-Caffeine-Na 8CIC-A2A-Etrumadenant-Na
37.50Consensusalpha2_offOrthosteric Ligandalpha2a_off alpha2c_off
37.50Consensusalpha2a_offOrthosteric Ligand6KUX-α2a-RS-79948
37.50Consensusbeta2_off_alloOrthosteric Ligand6OBA-β2-(S)-Alprenolol-GTPL11074
37.50Consensusgi_nucleotideOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
37.50Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
37.50Consensusnmur_onOrthosteric Ligandnmur1_on nmur2_on
37.50Consensusorexin_offOrthosteric Ligandox2_off ox1_off
37.04Single7VGXNeuropeptide Y7VGX-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
36.84Single2YDVNECA2YDV-A2A-NECA
36.84Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
36.84Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
36.84Single4UHRCGS216804UHR-A2A-CGS21680
36.84Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
36.84Single5G53NECA5G53-A2A-NECA-Gs
36.84Single5XRAAM115425XRA-CB1-AM11542
36.84Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
36.84Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
36.84Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
36.84Single6WGTLSD6WGT-5-HT2A-LSD
36.84Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
36.84Single7PX4PSB-21137PX4-A2A-PSB-2113
36.84Single7TUYGSK682753A7TUY-GPR183-GSK682753A
36.84Single7W41PD1762527W41-BB2-PD176252
36.84Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
36.84Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
36.84Single8DZPmomSalB8DZP-κ-momSalB-Gi1/&β;1/&γ;2
36.84Single8E0GBU728E0G-μ-BU72
36.84Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
36.84Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
36.84Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
36.84Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
36.84Consensus5ht1b_onOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
36.84Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
36.84Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
36.84Consensusbombesin_offOrthosteric Ligandbb2_off
36.84Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
36.84Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
36.84Consensuscyslt1_off_ortoalloOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
36.84Consensusdopamine_offOrthosteric Ligandd3_off d2_off d4_off
36.84Consensusgi_dopamineOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
36.84Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A2A-NECA-Gs/&β;1/&γ;1 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
36.84Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
36.84Consensusrelaxin_onOrthosteric Ligandrxfp4_on
36.67Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
36.67Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
36.67Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
36.36Single4AMJ(S)-Carvedilol4AMJ-β1-(S)-Carvedilol
36.36Single4IARErgotamine4IAR-5-HT1B-Ergotamine
36.36Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
36.36Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
36.36Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
36.36Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
36.36Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
36.36Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
36.00Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
36.00Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
36.00Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
36.00Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
36.00Consensusbombesin_onOrthosteric Ligandbb2_on bb1_on
36.00Consensusgs_neuromedinOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
36.00Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
35.71Single3RFMCaffeine3RFM-A2A-Caffeine
35.29Single2YDOAdenosine2YDO-A2A-Adenosine
35.29Single3UZCPubChem 1355666093UZC-A2A-PubChem 135566609
35.29Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
35.29Single4ZJCSB-6740424ZJC-OX1-SB-674042
35.29Single5UVIZM2413855UVI-A2A-ZM241385
35.29Single6AQFZM2413856AQF-A2A-ZM241385
35.29Single6MH8ZM2413856MH8-A2A-ZM241385
35.29Single6PS4ICI 118-5516PS4-β2-ICI 118-551
35.29Single6PS5(S)-Propranolol6PS5-β2-(S)-Propranolol
35.29Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
35.29Single6TP3Nemorexant6TP3-OX1-Nemorexant
35.29Single6TPGEMPA6TPG-OX2-EMPA
35.29Single6V9SGTPL114036V9S-OX1-GTPL11403
35.29Single7JOZVFP7JOZ-D1-VFP-Gs/&β;1/&γ;2
35.29Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
35.29Single7T32ZM2413857T32-A2A-ZM241385
35.29Single7XOVSR1461317XOV-CCKA-SR146131-Gs/&β;1/&γ;2
35.29Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
35.29Single8GDZEpinephrine8GDZ-β2-Epinephrine-Gs/&β;1/&γ;2
35.29Single8GEGEpinephrine8GEG-β2-Epinephrine-Gs/&β;1/&γ;2
35.29Single8GG3Epinephrine8GG3-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.29Single8GG8Epinephrine8GG8-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.29Single8GGKEpinephrine8GGK-β2-Epinephrine
35.29Single8GGMEpinephrine8GGM-β2-Epinephrine
35.29Single8GGPEpinephrine8GGP-β2-Epinephrine
35.29Single8GGQEpinephrine8GGQ-β2-Epinephrine
35.29Single8GGTEpinephrine8GGT-β2-Epinephrine
35.29Single8GURPubChem 1048958GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2
35.29Single8UNREpinephrine8UNR-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.29Single8UNSEpinephrine8UNS-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.29Single8UNZEpinephrine8UNZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.29Consensus5ht5_onOrthosteric Ligand5ht5a_on
35.29Consensus5ht5a_onOrthosteric Ligand7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
35.29Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
35.29Consensusgnrh_offOrthosteric Ligandgnrh1_off
35.29Consensusox1_offOrthosteric Ligand6TOT-OX1-Lemborexant 6TP4-OX1-ACT-462206 6TP6-OX1-Filorexant 6V9S-OX1-GTPL11403 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ7-OX1-SB-334867 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant
35.29Consensusox2_offOrthosteric Ligand6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant
35.00Single4AMIBucindolol4AMI-β1-Bucindolol
35.00Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
35.00Single4XEENeurotensin4XEE-NTS1-Neurotensin
35.00Single4XESNeurotensin4XES-NTS1-Neurotensin
35.00Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
35.00Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
35.00Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
35.00Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
35.00Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
35.00Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/&β;1/&γ;2
35.00Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/&β;1/γ1
35.00Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
35.00Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
35.00Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
35.00Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
35.00Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
35.00Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
35.00Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
35.00Single7YITNalfurafine7YIT-κ-Nalfurafine
35.00Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
35.00Single8IBUErythromycin A8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
35.00Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
35.00Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
35.00Single8WU1KCA8WU1-CB1-KCA-Arrestin1
35.00Consensusbeta1_onOrthosteric Ligand7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
35.00Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
35.00Consensusdp_offOrthosteric Liganddp2_off
35.00Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
35.00Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
35.00Consensusgs_bileacidOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
35.00Consensusgs_steroidOrthosteric Ligandgs_bileacid
35.00Consensusgs_trhOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
35.00Consensusopioid_offOrthosteric Ligandkop_off mop_off nop_off dop_off
35.00Consensuspeptide_offOrthosteric Ligandopioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
35.00Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
35.00Consensustsh_on_alloOther Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
34.78Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
34.78Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
34.78Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/&β;1/&γ;2
34.78Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
34.62Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
34.62Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
34.62Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
34.62Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
34.62Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
34.62Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
34.62Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
34.48Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
33.33Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
33.33Single2Y01Dobutamine2Y01-β1-Dobutamine
33.33Single3NY8ICI 118-5513NY8-β2-ICI 118-551
33.33Single3OE6IT1t3OE6-CXCR4-IT1t
33.33Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
33.33Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
33.33Single4BUONeurotensin4BUO-NTS1-Neurotensin
33.33Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
33.33Single4EJ4Naltrindole4EJ4-δ-Naltrindole
33.33Single4GBR(S)-Carazolol4GBR-β2-(S)-Carazolol
33.33Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
33.33Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
33.33Single5JQH(S)-Carazolol5JQH-β2-(S)-Carazolol
33.33Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
33.33Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
33.33Single5UIGJ3.651.884G5UIG-A2A-J3.651.884G
33.33Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
33.33Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
33.33Single6D27CAY104716D27-DP2-CAY10471
33.33Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
33.33Single6H7MSalbutamol6H7M-β1-Salbutamol
33.33Single6IBLArformoterol6IBL-β1-Arformoterol
33.33Single6PS0(S)-Carazolol6PS0-β2-(S)-Carazolol
33.33Single6PS1Timolol6PS1-β2-Timolol
33.33Single6PS2(S)-Alprenolol6PS2-β2-(S)-Alprenolol
33.33Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
33.33Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
33.33Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
33.33Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
33.33Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
33.33Single7F4DAlpha-MSH7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
33.33Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
33.33Single7LJCPubChem 867641037LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
33.33Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
33.33Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Single7SCGFH2107SCG-μ-FH210-Gi1/&β;1/&γ;2
33.33Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
33.33Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
33.33Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
33.33Single7V3ZPubMed 1048957V3Z-CB1-PubMed 104895
33.33Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
33.33Single7WC7Lisuride7WC7-5-HT2A-Lisuride
33.33Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
33.33Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
33.33Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
33.33Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
33.33Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
33.33Single8GE3Epinephrine8GE3-β2-Epinephrine-Gs/&β;1/&γ;2
33.33Single8GEBEpinephrine8GEB-β2-Epinephrine-Gs/&β;1/&γ;2
33.33Single8GEEEpinephrine8GEE-β2-Epinephrine-Gs/&β;1/&γ;2
33.33Single8GFWEpinephrine8GFW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8GFXEpinephrine8GFX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8GFYEpinephrine8GFY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8GFZEpinephrine8GFZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8GG0Epinephrine8GG0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8GG1Epinephrine8GG1-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8GG2Epinephrine8GG2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8GG6Epinephrine8GG6-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8GGBEpinephrine8GGB-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8GGJEpinephrine8GGJ-β2-Epinephrine
33.33Single8GGNEpinephrine8GGN-β2-Epinephrine
33.33Single8GGOEpinephrine8GGO-β2-Epinephrine
33.33Single8GGREpinephrine8GGR-β2-Epinephrine
33.33Single8GGUEpinephrine8GGU-β2-Epinephrine
33.33Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/&β;1/&γ;2
33.33Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
33.33Single8ID8TUG-8918ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
33.33Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2
33.33Single8J6QBeta-hydroxybutyrate8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
33.33Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Single8UNNEpinephrine8UNN-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8UNPEpinephrine8UNP-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8UO4Epinephrine8UO4-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
33.33Single8WRZ8D08WRZ-CB1-8D0-Arrestin1
33.33Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
33.33Consensusadrenergic_onOrthosteric Ligandbeta_on alpha_on
33.33Consensusbeta1_off_alloOrthosteric Ligand4BVN-β1-Cyanopindolol-Na
33.33Consensusbileacid_onOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
33.33Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
33.33Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
33.33Consensusdopamine_onOrthosteric Ligandd3_on d2_on d5_on d1_on
33.33Consensusendothelin_offOrthosteric Ligandetb_off
33.33Consensusetb_offOrthosteric Ligand5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500 5X93-ETB-K-8794
33.33Consensusetb_onOrthosteric Ligand8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
33.33Consensusffa4_on_alloOrthosteric Ligand8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Consensusffa_onOrthosteric Ligandffa4_on ffa1_on ffa2_on ffa3_on
33.33Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
33.33Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
33.33Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
33.33Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
33.33Consensushca3_onOrthosteric Ligand8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
33.33Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
33.33Consensussteroid_onOrthosteric Ligandbileacid_on
32.26Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
32.26Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
32.14Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
32.14Single8IY6Endothelin-18IY6-ETB-Endothelin-1
32.14Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
32.14Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
32.14Consensusgs_endothelinOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
32.00Single6JODAngiotensin II6JOD-AT2-Angiotensin II
32.00Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
32.00Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
32.00Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
32.00Consensusnmur2_onOrthosteric Ligand7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.82Single5ZTYAM102575ZTY-CB2-AM10257
31.82Single6PT3DPI-2876PT3-δ-DPI-287
31.82Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.82Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
31.82Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
31.82Single7XY6PubChem 117178317XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
31.82Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
31.82Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
31.82Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
31.82Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.82Single8X5YAstemizole8X5Y-H1-Astemizole
31.82Single8XZFWN5618XZF-Apelin-WN561-Gi1/&β;1/&γ;2
31.82Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
31.82Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
31.82Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
31.82Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.58Single2RH1(S)-Carazolol2RH1-β2-(S)-Carazolol
31.58Single2YCW(S)-Carazolol2YCW-β1-(S)-Carazolol
31.58Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
31.58Single5C1MBU725C1M-μ-BU72
31.58Single5D6L(S)-Carazolol5D6L-β2-(S)-Carazolol
31.58Single5WIUNemonapride5WIU-D4-Nemonapride
31.58Single5WIVNemonapride5WIV-D4-Nemonapride-Na
31.58Single5WQCEMPA5WQC-OX2-EMPA
31.58Single5X7D(S)-Carazolol5X7D-β2-(S)-Carazolol-PubChem 129318963
31.58Single5XPRBosentan5XPR-ETB-Bosentan
31.58Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
31.58Single6D26Fevipiprant6D26-DP2-Fevipiprant
31.58Single6GDGNECA6GDG-A2A-NECA-Gs/&β;1/&γ;1
31.58Single6LUQHaloperidol6LUQ-D2-Haloperidol
31.58Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
31.58Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
31.58Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
31.58Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
31.58Single7SBFPZM217SBF-μ-PZM21-Gi1/&β;1/&γ;2
31.58Single7SINNPS-21437SIN-CaS-NPS-2143
31.58Single7SINNPS-21437SIN-CaS-NPS-2143
31.58Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
31.58Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
31.58Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
31.58Single7WC6LSD7WC6-5-HT2A-LSD
31.58Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
31.58Single8JPCNeurotensin 8-138JPC-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
31.58Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
31.58Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
31.58Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
31.58Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.58Consensusa2a_onOrthosteric Ligand6GDG-A2A-NECA-Gs/&β;1/&γ;1
31.58Consensusamine_offOrthosteric Ligandadrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
31.58Consensusbeta2_offOrthosteric Ligand6PS2-β2-(S)-Alprenolol 6PS3-β2-(S)-Carvedilol 6PS5-β2-(S)-Propranolol 6PS6-β2-Timolol 2RH1-β2-(S)-Carazolol 6PS4-β2-ICI 118-551 3NY9-β2-PubChem 913103
31.58Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
31.58Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
31.58Consensuscb2_onOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
31.58Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
31.58Consensusd4_offOrthosteric Ligand5WIU-D4-Nemonapride
31.58Consensusd4_off_alloOrthosteric Ligand5WIV-D4-Nemonapride-Na
31.58Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
31.58Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
31.25Single3PBLEticlopride3PBL-D3-Eticlopride
31.25Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
31.25Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
31.25Single6HLLCP999946HLL-NK1-CP99994
31.25Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
31.25Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
31.25Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
31.25Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
31.25Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
31.25Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/&β;1/&γ;2
31.25Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2
31.25Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
31.25Single8EF6Morphine8EF6-μ-Morphine-Gi1/&β;1/&γ;2
31.25Single8GEIEpinephrine8GEI-β2-Epinephrine-Gs/&β;1/&γ;2
31.25Single8GGCEpinephrine8GGC-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
31.25Single8GGEEpinephrine8GGE-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
31.25Single8GGSEpinephrine8GGS-β2-Epinephrine
31.25Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/&β;1/&γ;2
31.25Single8UNVEpinephrine8UNV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
31.25Single8UNXEpinephrine8UNX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
31.25Consensusclass-t_onOrthosteric Ligandtaste2_on
31.25Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
31.25Consensusgs_class-tOrthosteric Ligandgs_taste
31.25Consensusgs_tasteOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
31.25Consensustaste2_onOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
31.03Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
31.03Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
30.77Single5MZPCaffeine5MZP-A2A-Caffeine-Na
30.77Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
30.77Single7KH0Acyclovir triphosphate7KH0-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
30.77Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
30.77Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
30.77Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
30.77Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.77Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
30.77Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.77Consensusgs_bradykininOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.77Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.56Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
30.43Single4XT1Fractalkine4XT1-US28-Fractalkine
30.43Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
30.43Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
30.43Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
30.43Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/&β;1/&γ;1
30.43Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
30.43Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.43Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
30.43Single8GHVPubChem 1459649038GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
30.43Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
30.43Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
30.43Consensusfpr-alx_onOrthosteric Ligandfpr1-alx_on fpr2-alx_on
30.43Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
30.00Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
30.00Single4BV0Neurotensin4BV0-NTS1-Neurotensin
30.00Single4DJHJDTic4DJH-κ-JDTic
30.00Single5D5A(S)-Carazolol5D5A-β2-(S)-Carazolol
30.00Single5D5B(S)-Carazolol5D5B-β2-(S)-Carazolol
30.00Single5X93K-87945X93-ETB-K-8794
30.00Single5XR8AM8415XR8-CB1-AM841
30.00Single6J21Aprepitant6J21-NK1-Aprepitant
30.00Single7B6WCyclazosin7B6W-α1b-Cyclazosin
30.00Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2
30.00Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
30.00Single7EW7PubChem 40774607EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
30.00Single7FEEPubMed 1048957FEE-CB1-PubMed 104895-ZCZ011
30.00Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1
30.00Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/&β;1/&γ;1
30.00Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
30.00Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
30.00Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2
30.00Single7W6PW967W6P-α2a-W96-Go/&β;1/&γ;2
30.00Single7W7EW587W7E-α2a-W58-Go/&β;1/&γ;2
30.00Single7WV9PubMed 1048957WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
30.00Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
30.00Single7XTQR3997XTQ-GPBA-R399-Gs/&β;1/&γ;2
30.00Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
30.00Single8EFLSR170188EFL-μ-SR17018-Gi1/&β;1/&γ;2
30.00Single8FMZNeurotensin/neuromedin N8FMZ-NTS1-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
30.00Single8GUSHU-3088GUS-CB2-HU-308-Gi1/&β;1/&γ;2
30.00Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2
30.00Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2
30.00Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2
30.00Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/&β;1/&γ;2
30.00Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
30.00Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/&β;1/&γ;2
30.00Single8JXVClozapine8JXV-H4-Clozapine-Gi1/&β;1/&γ;2
30.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
30.00Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
30.00Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
30.00Consensus5ht5_offOrthosteric Ligand5ht5a_off
30.00Consensus5ht_offOrthosteric Ligand5ht2_off 5ht5_off 5ht1_off
30.00Consensusalpha1b_offOrthosteric Ligand7B6W-α1b-Cyclazosin
30.00Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCZ-β1-Iodocyanopindolol
30.00Consensuschemerin_onOrthosteric Ligandcml1_on
30.00Consensuscml1_onOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
30.00Consensusgi_amineOrthosteric Ligandgi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
30.00Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
30.00Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
30.00Consensusnts1_on_alloOrthosteric Ligand8JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
30.00Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
30.00Consensussst4_onOrthosteric Ligand7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
29.63Single7SK3CXCL127SK3-ACKR3-CXCL12
29.63Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
29.63Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
29.41Single3ODUIT1t3ODU-CXCR4-IT1t
29.41Single4S0VSuvorexant4S0V-OX2-Suvorexant
29.41Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
29.41Single6AKXA4R6AKX-CCR5-A4R
29.41Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/&β;1/&γ;2
29.41Single6NWEOctyl Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
29.41Single6OYAAll-trans-retinal6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
29.41Single6TPJSuvorexant6TPJ-OX2-Suvorexant
29.41Single7BR3Elagolix7BR3-GnRH1-Elagolix
29.41Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
29.41Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2
29.41Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
29.41Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
29.41Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
29.41Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
29.41Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
29.41Single7TUZ7alpha,25-dihydroxycholesterol7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
29.41Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
29.41Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
29.41Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
29.41Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
29.41Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2
29.41Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
29.41Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2
29.41Single8EFOPZM218EFO-μ-PZM21-Gi1/&β;1/&γ;2
29.41Single8GEAEpinephrine8GEA-β2-Epinephrine-Gs/&β;1/&γ;2
29.41Single8GECEpinephrine8GEC-β2-Epinephrine-Gs/&β;1/&γ;2
29.41Single8GEFEpinephrine8GEF-β2-Epinephrine-Gs/&β;1/&γ;2
29.41Single8GG7Epinephrine8GG7-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
29.41Single8GGAEpinephrine8GGA-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
29.41Single8GGVEpinephrine8GGV-β2-Epinephrine
29.41Single8GGWEpinephrine8GGW-β2-Epinephrine
29.41Single8GGXEpinephrine8GGX-β2-Epinephrine
29.41Single8GH0Epinephrine8GH0-β2-Epinephrine
29.41Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/&β;1/&γ;2
29.41Single8IHKAcifran8IHK-HCA3-Acifran
29.41Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
29.41Single8UNOEpinephrine8UNO-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
29.41Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
29.41Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
29.41Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
29.41Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
29.41Consensusgt_class-aOrthosteric Ligandgt_opsin
29.41Consensusgt_opsinOrthosteric Ligandgt_sensory
29.41Consensusgt_sensoryOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
29.41Consensusm2_on_alloOther Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
29.41Consensusmelatonin_onOrthosteric Ligandmt1_on mt2_on
29.17Single6HLOAprepitant6HLO-NK1-Aprepitant
29.17Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
29.17Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
29.17Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
29.17Single7SK5CXCL127SK5-ACKR3-CXCL12
29.17Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
29.17Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
29.03Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
28.57Single3D4STimolol Maleate3D4S-β2-Timolol Maleate
28.57Single4GRVNeurotensin 8-134GRV-NTS1-Neurotensin 8-13
28.57Single6H7N(S)-Xamoterol6H7N-β1-(S)-Xamoterol
28.57Single6KQIPubMed 1048956KQI-CB1-PubMed 104895-ORG27569
28.57Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
28.57Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
28.57Single6OS2TRV0266OS2-AT1-TRV026
28.57Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/&β;1/&γ;2
28.57Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
28.57Single6YVRNTS8-136YVR-NTS1-NTS8-13
28.57Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/&β;1/&γ;2
28.57Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
28.57Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
28.57Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
28.57Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
28.57Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2
28.57Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
28.57Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
28.57Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
28.57Single7XMTJ-21567XMT-SST4-J-2156-Gi1/&β;1/&γ;2
28.57Single7Y66BM2137Y66-C5a1-BM213-Gi1/&β;1/&γ;2
28.57Single8IJDMK68928IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
28.57Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
28.57Single8JPBNeurotensin 8-138JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
28.57Single8JWYPubChem 1684517108JWY-A2A-PubChem 168451710
28.57Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
28.57Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
28.57Consensusat2_offOrthosteric Ligand7JNI-AT2-Olodanrigan
28.57Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
28.57Consensuscannabinoid_onOrthosteric Ligandcb1_on cb2_on
28.57Consensuscb1_off_alloOrthosteric Ligand6KQI-CB1-PubMed 104895-ORG27569
28.57Consensuscb1_onOrthosteric Ligand8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
28.57Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
28.57Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
28.57Consensuschemokine_offOrthosteric Ligandcxcr_off
28.57Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II
28.57Consensuscxcr_offOrthosteric Ligandcxcr4_off
28.57Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
28.57Consensusgabab_offOther Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
28.57Consensusgi_cannabinoidOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
28.57Consensusleuko_offOrthosteric Ligandblt_off cyslt_off
28.00Single3OE0CVX153OE0-CXCR4-CVX15
28.00Single6W25SHU91196W25-MC4-SHU9119-Ca
28.00Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.00Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
28.00Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
28.00Consensusgi_chemerinOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
28.00Consensusgi_formylpeptideOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
28.00Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.00Consensusmc5_onOrthosteric Ligand8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
28.00Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
27.78Single3REYPubChem 56973REY-A2A-PubChem 5697
27.78Single4DKLBeta-funaltrexamine4DKL-μ-Beta-funaltrexamine
27.78Single4MBSMaraviroc4MBS-CCR5-Maraviroc
27.78Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
27.78Single5TE3Octyl Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
27.78Single6DS0Ly2660976DS0-5-HT2B-Ly266097
27.78Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
27.78Single6IQLL7458706IQL-D4-L745870
27.78Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
27.78Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
27.78Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
27.78Single6TPNHTL66416TPN-OX2-HTL6641
27.78Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
27.78Single6ZDVPubChem 9840736ZDV-A2A-PubChem 984073-Na
27.78Single7BB6Acyclovir triphosphate7BB6-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
27.78Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/&β;1/&γ;2
27.78Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
27.78Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
27.78Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
27.78Single7F0TDopamine7F0T-D1-Dopamine-Gs/&β;1/&γ;2
27.78Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/&β;1/&γ;2
27.78Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
27.78Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
27.78Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
27.78Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
27.78Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
27.78Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
27.78Single7XJJGalanin7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
27.78Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
27.78Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
27.78Single8GE1Epinephrine8GE1-β2-Epinephrine-Gs/&β;1/&γ;2
27.78Single8GE4Epinephrine8GE4-β2-Epinephrine-Gs/&β;1/&γ;2
27.78Single8GE6Epinephrine8GE6-β2-Epinephrine-Gs/&β;1/&γ;2
27.78Single8GE7Epinephrine8GE7-β2-Epinephrine-Gs/&β;1/&γ;2
27.78Single8GE8Epinephrine8GE8-β2-Epinephrine-Gs/&β;1/&γ;2
27.78Single8GE9Epinephrine8GE9-β2-Epinephrine-Gs/&β;1/&γ;2
27.78Single8GFVEpinephrine8GFV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
27.78Single8GG4Epinephrine8GG4-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
27.78Single8GG5Epinephrine8GG5-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
27.78Single8GGIEpinephrine8GGI-β2-Epinephrine
27.78Single8GGLEpinephrine8GGL-β2-Epinephrine
27.78Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
27.78Single8JERAcipimox8JER-HCA2-Acipimox-Go/&β;1/&γ;2
27.78Single8JIMMMF8JIM-HCA2-MMF-Gi1/&β;1/&γ;2
27.78Single8K5CAcipimox8K5C-HCA2-Acipimox
27.78Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
27.78Single8UNQEpinephrine8UNQ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
27.78Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/&β;1/&γ;2
27.78Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
27.78Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.78Consensusd1_on_alloOrthosteric Ligand7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
27.78Consensusd3_onOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
27.78Consensusdop_off_alloOrthosteric Ligand4N6H-δ-Naltrindole-Na
27.78Consensusffa2_onOrthosteric Ligand8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
27.78Consensusgi_melatoninOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
27.78Consensusgo_galaninOrthosteric Ligand7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
27.78Consensusgs_tarOrthosteric Ligand8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
27.78Consensush3_on_alloOrthosteric Ligand7F61-H3-PF-03654746-Cholesterol
27.78Consensushca_onOrthosteric Ligandhca2_on hca3_on
27.78Consensushcar_onOrthosteric Ligandhca_on
27.78Consensuslh_on_alloOther Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
27.27Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
27.27Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
27.27Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
27.27Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
27.27Single6K1QIRL25006K1Q-ETB-IRL2500
27.27Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
27.27Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
27.27Single7UM4AS26747237UM4-5-HT5A-AS2674723
27.27Single7XK2MK68927XK2-HCA2-MK6892-Gi1/&β;1/&γ;2
27.27Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
27.27Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
27.27Single8GAGYVF8GAG-CB1-YVF-Gi1/&β;1/&γ;2
27.27Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
27.27Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
27.27Consensus5ht5a_offOrthosteric Ligand7UM4-5-HT5A-AS2674723
27.27Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
27.27Consensusgi_neurotensinOrthosteric Ligand7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
27.27Consensusgs_galaninOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
27.27Consensusot_onOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
26.92Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
26.92Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
26.92Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.92Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
26.92Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
26.92Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
26.92Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
26.67Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
26.67Single7MTBAll-trans-retinal7MTB-Rhodopsin-All-trans-retinal-GRK1
26.67Consensushca2_on_alloOrthosteric Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
26.67Consensussensory_onOrthosteric Ligandopsin_on
26.32Single3NYA(S)-Alprenolol3NYA-β2-(S)-Alprenolol
26.32Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
26.32Single4X1HNonyl Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
26.32Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
26.32Single5TGZAM65385TGZ-CB1-AM6538
26.32Single6DRXLisuride6DRX-5-HT2B-Lisuride
26.32Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
26.32Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
26.32Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
26.32Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
26.32Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
26.32Single7CFMP3957CFM-GPBA-P395-Gs/&β;1/&γ;2
26.32Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
26.32Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
26.32Single7F83PF-051904577F83-Ghrelin-PF-05190457
26.32Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
26.32Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
26.32Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2
26.32Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/&β;1/&γ;2
26.32Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
26.32Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
26.32Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
26.32Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
26.32Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/&β;1/&γ;2
26.32Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/&β;1/&γ;2
26.32Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
26.32Single8JJOAlprenolol8JJO-β2-Alprenolol
26.32Single8JLZST19368JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
26.32Single8K5DGSK2560738K5D-HCA2-GSK256073
26.32Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
26.32Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
26.32Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
26.32Consensus5ht1a_onOrthosteric Ligand8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
26.32Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
26.32Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
26.32Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
26.32Consensusalpha2_onOrthosteric Ligandalpha2a_on alpha2b_on
26.32Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
26.32Consensusamine_onOrthosteric Ligandadrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on
26.32Consensuscb1_on_alloOrthosteric Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
26.32Consensusfsh_on_alloOther Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
26.32Consensusgi_5htOrthosteric Ligand7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
26.32Consensusgi_hcaOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
26.32Consensusgi_hcarOrthosteric Ligandgi_hca
26.32Consensushca2_onOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
26.32Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
26.32Consensusp2y12_offOrthosteric Ligand4NTJ-P2Y12-AZD1283 7PP1-P2Y12-Selatogrel
26.32Consensustar_onOrthosteric Ligandta1_on
26.09Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.09Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
26.09Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
26.09Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
26.09Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.09Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
26.09Single8SAI1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
26.09Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
26.09Consensusfpr2-alx_onOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
26.09Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
26.09Consensusgo_vasopressinOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
26.09Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
26.09Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
25.93Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
25.93Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
25.93Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
25.93Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
25.00Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
25.00Single3OE8IT1t3OE8-CXCR4-IT1t
25.00Single3UZAGTPL92363UZA-A2A-GTPL9236
25.00Single4NTJAZD12834NTJ-P2Y12-AZD1283
25.00Single4XNWMRS25004XNW-P2Y1-MRS2500
25.00Single4XT3Fractalkine4XT3-US28-Fractalkine
25.00Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
25.00Single5WKTOctyl Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
25.00Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
25.00Single6FUFAll-trans-retinal6FUF-Rhodopsin-All-trans-retinal-Go/&β;1/&γ;2
25.00Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
25.00Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
25.00Single6ME5Agomelatine6ME5-MT1-Agomelatine
25.00Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
25.00Single6ME9Ramelteon6ME9-MT2-Ramelteon
25.00Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
25.00Single6PS6Timolol6PS6-β2-Timolol
25.00Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
25.00Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
25.00Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
25.00Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
25.00Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
25.00Single7MT8All-trans-retinal7MT8-Rhodopsin-All-trans-retinal-GRK1
25.00Single7MT9All-trans-retinal7MT9-Rhodopsin-All-trans-retinal-GRK1
25.00Single7MTAAll-trans-retinal7MTA-Rhodopsin-All-trans-retinal-GRK1
25.00Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
25.00Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
25.00Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
25.00Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
25.00Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
25.00Single7WC5Psilocin7WC5-5-HT2A-Psilocin
25.00Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
25.00Single7YXAONO-54306087YXA-S1P5-ONO-5430608
25.00Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
25.00Single8GGZEpinephrine8GGZ-β2-Epinephrine
25.00Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2
25.00Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
25.00Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
25.00Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
25.00Single8J6RMK68928J6R-HCA2-MK6892-Gi1/&β;1/&γ;2
25.00Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
25.00Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
25.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
25.00Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
25.00Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide 6DRX-5-HT2B-Lisuride
25.00Consensusalpha2a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
25.00Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
25.00Consensusgo_amineOrthosteric Ligandgo_adrenergic go_muscarinic go_5ht
25.00Consensusnmur1_onOrthosteric Ligand7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Consensusopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
25.00Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
25.00Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
24.14Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
24.00Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
24.00Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
24.00Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
24.00Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
24.00Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
24.00Consensuscx3cr_onOrthosteric Ligandcx3cr1_on
24.00Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
24.00Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
23.81Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
23.81Single6J20Aprepitant6J20-NK1-Aprepitant
23.81Single6TQ7SB-3348676TQ7-OX1-SB-334867
23.81Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
23.81Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
23.81Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
23.81Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
23.81Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
23.81Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
23.81Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
23.81Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
23.81Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.81Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2
23.81Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
23.81Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
23.81Single8JXWVUF68848JXW-H4-VUF6884-Gi1/&β;1/&γ;2
23.81Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.81Consensusangiotensin_offOrthosteric Ligandat1_off at2_off
23.81Consensusgo_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
23.81Consensusgs_ffaOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2 8GDB-EP4-PGE2-Gs/&β;1/&γ;2
23.81Consensush1_offOrthosteric Ligand3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole 8X63-H1-Mepyramine 8X64-H1-Desloratadine
23.81Consensushistamine_offOrthosteric Ligandh1_off
23.81Consensusnk1_offOrthosteric Ligand6J20-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
23.81Consensusnpy_offOrthosteric Ligandnpy2_off npy1_off
23.81Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
23.53Single5L7IVismodegib5L7I-SMO-Vismodegib
23.53Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
23.53Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
23.53Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
23.53Single6QNOAll-trans-retinal6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
23.53Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
23.53Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
23.53Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2
23.53Single7SRQLSD7SRQ-5-HT2B-LSD
23.53Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2
23.53Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/&β;1/&γ;2
23.53Single8GGYEpinephrine8GGY-β2-Epinephrine
23.53Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2
23.53Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2
23.53Single8IJANiacin8IJA-HCA2-Niacin-Gi1/&β;1/&γ;2
23.53Single8IY9Niacin8IY9-HCA2-Niacin-Go/&β;1/&γ;2
23.53Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
23.53Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
23.53Single8K5BNiacin8K5B-HCA2-Niacin
23.53Consensus5ht4_onOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
23.53Consensusm4_on_alloOther Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
23.53Consensusmt1_onOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
23.53Consensusmt2_onOrthosteric Ligand7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
23.53Consensuspth_onOrthosteric Ligandpth1_on pth2_on
23.33Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
23.33Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
23.08Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
23.08Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
23.08Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
23.08Single7XNACYN1548067XNA-SST2-CYN154806
23.08Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
23.08Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
23.08Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
23.08Consensuscx3cr1_onOrthosteric Ligand7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
23.08Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
22.73Single4PY02MeSATP4PY0-P2Y12-2MeSATP
22.73Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
22.73Single6HLPNetupitant6HLP-NK1-Netupitant
22.73Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
22.73Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
22.73Single6ZG4HTL00099366ZG4-M1-HTL0009936
22.73Single7K15MKD0467K15-BLT1-MKD046-Na
22.73Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
22.73Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
22.73Single7WCNAR2314537WCN-GPR119-AR231453-Gs/&β;1/&γ;2
22.73Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.73Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
22.73Single8JWZAB9288JWZ-A2A-AB928-Na
22.73Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/&β;1/&γ;2
22.73Consensusblt1_offOrthosteric Ligand7K15-BLT1-MKD046-Na
22.73Consensusblt_offOrthosteric Ligandblt1_off
22.73Consensusgi_class-fOther Ligandgi_frizzled
22.73Consensusgi_frizzledOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
22.73Consensusgpr119_onOrthosteric Ligand7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
22.73Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
22.73Consensusnts1_offOrthosteric Ligand6Z4Q-NTS1-SR142948A 6Z4S-NTS1-SR48692
22.73Consensusnts1_onOrthosteric Ligand6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
22.73Consensusnts_offOrthosteric Ligandnts1_off
22.73Consensusnts_onOrthosteric Ligandnts1_on
22.73Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
22.58Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
22.22Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
22.22Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
22.22Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
22.22Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
22.22Single6AKYMaraviroc6AKY-CCR5-Maraviroc
22.22Single6B73PubChem 1319551386B73-κ-PubChem 131955138
22.22Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
22.22Single6ME2Ramelteon6ME2-MT1-Ramelteon
22.22Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
22.22Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
22.22Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
22.22Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2
22.22Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/&β;1/&γ;2
22.22Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;1
22.22Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
22.22Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
22.22Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
22.22Single7W0OElabela7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
22.22Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
22.22Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
22.22Single8FN0Neurotensin/neuromedin N8FN0-NTS1-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
22.22Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
22.22Single8IHFMK68928IHF-HCA2-MK6892-Gi1/&β;1/&γ;2
22.22Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2
22.22Single8IW4Spermidine8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2
22.22Single8IWESpermidine8IWE-TAAR9-Spermidine
22.22Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
22.22Single8J6IMK68928J6I-HCA2-MK6892-Gi1/&β;1/&γ;2
22.22Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
22.22Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
22.22Consensusalpha1_onOrthosteric Ligandalpha1a_on
22.22Consensusalpha1a_onOrthosteric Ligand7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.22Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
22.22Consensusffa3_on_alloOrthosteric Ligand8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
22.22Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
22.22Consensusgs_5htOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2 7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2 7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.22Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
22.22Consensusmglu_onOther Ligandmglu2_on mglu4_on
22.22Consensusp2y_offOrthosteric Ligandp2y1_off p2y12_off
21.88Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
21.74Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
21.74Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
21.74Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
21.74Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
21.74Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
21.74Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
21.74Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
21.74Single7XZ6APD6687XZ6-GPR119-APD668-Gs/&β;1/&γ;2
21.74Single8E9YPubChem 4466038E9Y-M3-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.74Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.43Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
21.43Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
21.43Single8WCBCyclohexylammonium ion8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.43Single8WCCCyclohexylammonium ion8WCC-TA1-Cyclohexylammonium ion
21.43Consensusbk1_onOrthosteric Ligand7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.05Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
21.05Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
21.05Single6A94Zotepine6A94-5-HT2A-Zotepine
21.05Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
21.05Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
21.05Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
21.05Single6TPKRetosiban6TPK-OT-Retosiban
21.05Single6VI4JDTic6VI4-κ-JDTic
21.05Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
21.05Single6ZG9GSK10347026ZG9-M1-GSK1034702
21.05Single6ZINSR486926ZIN-NTS1-SR48692
21.05Single7CMVPD1289077CMV-D3-PD128907-Gi1/&β;1/&γ;2
21.05Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
21.05Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2
21.05Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
21.05Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.05Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
21.05Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
21.05Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
21.05Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
21.05Single8GCML9026888GCM-EP4-L902688-Gi1/&β;1/&γ;2
21.05Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2
21.05Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.05Single8HQN9(S)-HODE8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
21.05Single8JHNMMF8JHN-HCA2-MMF-Go/&β;1/&γ;2
21.05Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
21.05Single8JLNT1AM8JLN-TA1-T1AM-Gs/&β;1/&γ;2
21.05Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2
21.05Single8K4NVF08K4N-GPR34-VF0-Gi1/&β;1/&γ;2
21.05Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.05Single8UHBRO52563908UHB-TA1-RO5256390-Gs/&β;1/&γ;2
21.05Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
21.05Consensusalpha2b_onOrthosteric Ligand6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
21.05Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
21.05Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
21.05Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
21.05Consensuscxcr_onOrthosteric Ligandcxcr1_on cxcr2_on
21.05Consensusm1_off_alloOther Ligand6WJC-M1-Atropine-Muscarinic toxin 7
21.05Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
21.05Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
21.05Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
21.05Consensuss1p_offOrthosteric Ligands1p1_off
21.05Consensussensory_offOrthosteric Ligandopsin_off
21.05Consensusvasopressin-ot_offOrthosteric Ligandot_off
20.83Single5EE7MK08935EE7-Glucagon-MK0893
20.83Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
20.83Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
20.83Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
20.83Single8INRAlpha-MSH8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
20.83Single8IYHMK68928IYH-HCA2-MK6892-Go/&β;1/&γ;2
20.83Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
20.83Consensusclass-d_offOrthosteric Ligandste2_off
20.69Single6FJ3PTH6FJ3-PTH1-PTH
20.69Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
20.69Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
20.69Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
20.59Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
20.59Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
20.00Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
20.00Single3PXOAll-trans-retinal3PXO-Rhodopsin-All-trans-retinal
20.00Single4QIMPubChem 249053754QIM-SMO-PubChem 24905375
20.00Single4YAYZD-71554YAY-AT1-ZD-7155
20.00Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
20.00Single5DHGPubChem 250014125DHG-NOP-PubChem 25001412
20.00Single5DYSAll-trans-retinal5DYS-Rhodopsin-All-trans-retinal
20.00Single5T04Neurotensin5T04-NTS1-Neurotensin
20.00Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
20.00Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
20.00Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
20.00Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2
20.00Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
20.00Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
20.00Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
20.00Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
20.00Single7QA8Peptide7QA8-STE2-Peptide
20.00Single7QA8Peptide7QA8-STE2-Peptide
20.00Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
20.00Single7T2GMitragynine pseudoindoxyl7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
20.00Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
20.00Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
20.00Single7WC4Serotonin7WC4-5-HT2A-Serotonin
20.00Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
20.00Single8GEJEpinephrine8GEJ-β2-Epinephrine-Gs/&β;1/&γ;2
20.00Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
20.00Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
20.00Single8J18(3R)-3-hydroxydodecanoic acid8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
20.00Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
20.00Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single8X63Mepyramine8X63-H1-Mepyramine
20.00Single8X64Desloratadine8X64-H1-Desloratadine
20.00Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
20.00Consensusclass-d_offOrthosteric Ligandste2_off
20.00Consensusgo_class-b1Orthosteric Ligandgo_crf
20.00Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
20.00Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
20.00Consensussmo_offOrthosteric Ligand5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
19.35Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
19.35Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
19.35Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
19.35Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
19.23Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
19.23Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
19.23Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
19.23Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
19.23Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
19.23Consensussst_offOrthosteric Ligandsst2_off
19.05Single4PHUFasiglifam4PHU-FFA1 (GPR40)-Fasiglifam
19.05Single5ZK3Quinuclidinyl benzilate hydrobromide5ZK3-M2-Quinuclidinyl benzilate hydrobromide
19.05Single6Z4SSR486926Z4S-NTS1-SR48692
19.05Single7C4SS1P7C4S-S1P3-S1P
19.05Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
19.05Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
19.05Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
19.05Single8J19PubChem 1270454228J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
18.92Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
18.75Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
18.75Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
18.75Single6OY9All-trans-retinal6OY9-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
18.75Single6TQ9SB-4081246TQ9-OX1-SB-408124
18.75Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
18.75Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
18.75Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.75Single8WC5Tetramethylammonium ion8WC5-TA1-Tetramethylammonium ion-chim(NtGi1-Gs)/&β;1/&γ;2
18.75Consensusgs_crfOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
18.52Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
18.52Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
18.18Single3UONQuinuclidinyl benzilate hydrobromide3UON-M2-Quinuclidinyl benzilate hydrobromide
18.18Single4U15Tiotropium4U15-M3-Tiotropium
18.18Single5TZR-5TZR-FFA1 (GPR40)-MK8666
18.18Single5V54Methiothepin5V54-5-HT1B-Methiothepin
18.18Single5V56TC1145V56-SMO-TC114
18.18Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
18.18Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
18.18Single6E59L-7607356E59-NK1-L-760735
18.18Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
18.18Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
18.18Single6OL9Tiotropium6OL9-M5-Tiotropium
18.18Single6OS1TRV0266OS1-AT1-TRV026
18.18Single7EPENAM5637EPE-mGlu-NAM563
18.18Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2
18.18Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
18.18Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
18.18Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
18.18Single8G056-OAU8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
18.18Single8JD0J9R8JD0-mGlu2; mGlu3-Glutamate-J9R
18.18Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/&β;1/&γ;2
18.18Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
18.18Consensus5ht1_offOrthosteric Ligand5ht1b_off
18.18Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
18.18Consensusgi_muscarinicOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
18.18Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl Scopolamine 5ZHP-M3-PubChem 134828589
18.18Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
18.18Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
17.86Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
17.86Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
17.86Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
17.65Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
17.65Single3PQRAll-trans-retinal3PQR-Rhodopsin-All-trans-retinal-Gt(CT)
17.65Single6LI0GTPL98046LI0-GPR52-GTPL9804
17.65Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
17.65Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/&β;1/&γ;2
17.65Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
17.65Single8EITDoconexent8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
17.65Single8F76-8F76-OR51E2-Gs/&β;1/&γ;2
17.65Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/&β;1/&γ;2
17.65Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/&β;1/&γ;2
17.65Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/&β;1/&γ;2
17.65Single8POKHistamine8POK-H2-Histamine-Gs/&β;1/&γ;2
17.65Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
17.65Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.65Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
17.65Consensussmo_off_alloOrthosteric Ligand6D32-SMO-Cyclopamine-Cyclopamine
17.39Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
17.39Single4N4WSANT-14N4W-SMO-SANT-1
17.39Single5CXVTiotropium5CXV-M1-Tiotropium
17.39Single6A93Risperidone6A93-5-HT2A-Risperidone
17.39Single6CM4Risperidone6CM4-D2-Risperidone
17.39Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
17.39Single7DFPSpiperone7DFP-D2-Spiperone
17.39Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
17.39Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/&β;1/&γ;2
17.39Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
17.39Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.39Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.39Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.39Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
17.39Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
17.39Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg3_on
17.39Consensusclass-b2_onOrthosteric Ligandadgrg_on
17.39Consensusgi_prostanoidOrthosteric Ligand8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GDC-EP3-PGE2-Gi1/&β;1/&γ;2 8GCM-EP4-L902688-Gi1/&β;1/&γ;2
17.39Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
17.24Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
17.24Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
17.24Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
17.24Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
17.24Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
17.24Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
17.14Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
16.67Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
16.67Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
16.67Single4O9RCyclopamine4O9R-SMO-Cyclopamine
16.67Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
16.67Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
16.67Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
16.67Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
16.67Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
16.67Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/&β;1/&γ;2
16.67Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
16.67Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
16.67Single7UL2SR486927UL2-NTS1-SR48692-Na
16.67Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
16.67Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
16.67Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Single8ITFDMCHA8ITF-TAAR9-DMCHA-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
16.67Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
16.67Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
16.67Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
16.67Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single8X2K5YM8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
16.67Consensusclass-d_onOrthosteric Ligandste2_on
16.67Consensusfpa_onOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Consensusghrh_onOrthosteric Ligand7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
16.67Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
16.67Consensusgo_adhesionOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
16.67Consensusgo_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
16.67Consensusgo_class-b2Orthosteric Ligandgo_adhesion
16.67Consensusgo_proteinOrthosteric Ligandgo_chemokine
16.67Consensusnts1_off_alloOrthosteric Ligand7UL2-NTS1-SR48692-Na
16.22Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
16.13Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
16.13Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
16.13Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
16.13Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
16.13Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
16.13Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
16.13Consensusgi_class-dOrthosteric Ligandgi_ste
16.13Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
16.13Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
16.00Single6KNMJN241-96KNM-Apelin-JN241-9
16.00Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
16.00Single7SK9CCX6627SK9-ACKR3-CCX662
16.00Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.79Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
15.79Single4BWBNeurotensin4BWB-NTS1-Neurotensin
15.79Single4QINSAG1.54QIN-SMO-SAG1.5
15.79Single5DHHSB-6121115DHH-NOP-SB-612111
15.79Single5U09Taranabant5U09-CB1-Taranabant
15.79Single5ZKQABT-4915ZKQ-PAF-ABT-491
15.79Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
15.79Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
15.79Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
15.79Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
15.79Single6WWZCCL206WWZ-CCR6-CCL20-Go/&β;1/&γ;2
15.79Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
15.79Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
15.79Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
15.79Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
15.79Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
15.79Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
15.79Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2
15.79Single8A6CAll-trans-retinal8A6C-Rhodopsin-All-trans-retinal
15.79Single8A6DAll-trans-retinal8A6D-Rhodopsin-All-trans-retinal
15.79Single8A6EAll-trans-retinal8A6E-Rhodopsin-All-trans-retinal
15.79Single8HMPPubChem 699214798HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
15.79Single8HOCImetit8HOC-H4-Imetit-Gi1/&β;1/&γ;2
15.79Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/&β;1/&γ;2
15.79Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
15.79Single8U8FPML8U8F-GPR3-PML-Gs/&β;1/&γ;2
15.79Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
15.79Consensus5ht2_onOrthosteric Ligand5ht2a_on 5ht2c_on
15.79Consensus5ht2c_onOrthosteric Ligand8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.79Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
15.79Consensusclass-f_offOrthosteric Ligandsmo_off
15.79Consensusgi_histamineOrthosteric Ligand8HN8-H4-Histamine-Gi1/&β;1/&γ;2 8HOC-H4-Imetit-Gi1/&β;1/&γ;2
15.79Consensusgs_histamineOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.79Consensush4_onOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.79Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
15.79Consensusopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
15.62Single6LMLGlucagon6LML-Glucagon-Glucagon
15.62Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
15.62Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
15.62Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
15.62Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
15.62Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
15.62Consensuscrf1_onOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
15.62Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
15.62Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
15.38Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
15.38Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
15.00Single3RZECidoxepin3RZE-H1-Cidoxepin
15.00Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
15.00Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
15.00Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
15.00Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
15.00Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
15.00Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
15.00Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
15.00Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2
15.00Single7VODCariprazine7VOD-5-HT2A-Cariprazine
15.00Single7VV6C48/807VV6-MRGPRX2-C48/80
15.00Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
15.00Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
15.00Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.00Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2
15.00Single8K2WAMG4878K2W-CXCR3-AMG487
15.00Single8T3VDHA8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.00Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/&β;1/&γ;2
15.00Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6WH4-5-HT2A-Methiothepin 7VOE-5-HT2A-Aripiprazole 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 6A93-5-HT2A-Risperidone
15.00Consensus5ht2a_onOrthosteric Ligand7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.00Consensusgi_class-fOrthosteric Ligandgi_frizzled
15.00Consensusgi_frizzledOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
15.00Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
15.00Consensusm1_off_alloOrthosteric Ligand6WJC-M1-Atropine-Muscarinic toxin 7
14.81Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
14.81Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
14.71Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
14.71Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
14.71Consensusglp_onOrthosteric Ligandglp1_on glp2_on
14.63Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
14.29Single4DAJTiotropium4DAJ-M3-Tiotropium
14.29Single4MQSIperoxo4MQS-M2-Iperoxo
14.29Single4U14Tiotropium4U14-M3-Tiotropium
14.29Single4U16N-Methyl Scopolamine4U16-M3-N-Methyl Scopolamine
14.29Single5YC8N-Methyl Scopolamine5YC8-M2-N-Methyl Scopolamine
14.29Single5ZK8N-Methyl Scopolamine5ZK8-M2-N-Methyl Scopolamine
14.29Single5ZKCN-Methyl Scopolamine5ZKC-M2-N-Methyl Scopolamine
14.29Single6GPSMK08126GPS-CCR2-MK0812
14.29Single6IIVDaltroban6IIV-TP-Daltroban
14.29Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.29Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
14.29Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
14.29Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
14.29Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
14.29Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
14.29Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
14.29Single8EJCTAK-8758EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
14.29Single8EJKTAK-8758EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
14.29Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/&β;1/&γ;2
14.29Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-alpha-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
14.29Consensusffa1_onOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.29Consensusgo_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
14.29Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
14.29Consensushcar_offOrthosteric Ligandsuccinate_off
14.29Consensushistamine_onOrthosteric Ligandh1_on h4_on
14.29Consensusm2_on_alloOrthosteric Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
14.29Consensusm4_on_alloOrthosteric Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
14.29Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
14.29Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
14.29Consensusprostanoid_offOrthosteric Ligandep_off tp_off dp_off
14.29Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
14.29Consensustachykinin_offOrthosteric Ligandnk1_off
14.29Consensustp_offOrthosteric Ligand6IIV-TP-Daltroban 6IIU-TP-Ramatroban
14.29Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
13.89Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
13.79Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
13.79Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
13.79Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
13.79Consensusclass-d_onOrthosteric Ligandste2_on
13.79Consensusgi_class-dOrthosteric Ligandgi_ste
13.79Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
13.64Single4JKVTaladegib (LY2940680)4JKV-SMO-Taladegib (LY2940680)
13.64Single5CGCHTL142425CGC-mGlu5-HTL14242
13.64Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
13.64Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
13.64Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
13.64Single6GPXMK08126GPX-CCR2-MK0812
13.64Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
13.64Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
13.64Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2
13.64Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
13.64Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.64Single8EA0Iperoxo8EA0-M3-Iperoxo
13.64Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2
13.64Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
13.64Consensusccr2_off_alloOther Ligand5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
13.64Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
13.64Consensusep_offOrthosteric Ligandep4_off
13.64Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
13.64Consensusgs_muscarinicOrthosteric Ligand8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.64Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
13.64Consensusm2_offOrthosteric Ligand5ZKB-M2-AF-DX 384 5ZKC-M2-N-Methyl Scopolamine 5ZK3-M2-Quinuclidinyl benzilate hydrobromide
13.64Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.33Single4A4MAll-trans-retinal4A4M-Rhodopsin-All-trans-retinal-Gt(CT)
13.33Single5EN0All-trans-retinal5EN0-Rhodopsin-All-trans-retinal-Gt(CT)
13.33Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
13.33Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
13.33Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
13.04Single5V57TC1145V57-SMO-TC114
13.04Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
13.04Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2
13.04Single7F1TMIP-1a7F1T-CCR5-MIP-1a
13.04Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
13.04Single8X79MRE-2698X79-I2-MRE-269-Gs/&β;1/&γ;2
13.04Consensuss1p2_onOrthosteric Ligand7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
12.90Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
12.90Single7D3SSecretin7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
12.90Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
12.90Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
12.90Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
12.90Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
12.50Single5X33BIIL2605X33-BLT1-BIIL260
12.50Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
12.50Single6IIURamatroban6IIU-TP-Ramatroban
12.50Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
12.50Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
12.50Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
12.50Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
12.50Single7XKEBetahydroxyandrosterone7XKE-ADGRG2-Betahydroxyandrosterone-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
12.50Single8GCPPGE28GCP-EP4-PGE2-Gi1/&β;1/&γ;2
12.50Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/&β;1/&γ;2
12.50Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
12.50Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
12.50Consensusprostanoid_onOrthosteric Ligandep_on fpa_on
12.12Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
12.12Consensuscalcitonin_onOrthosteric Ligandct_on ctlike_on
12.12Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
12.12Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
12.00Single5CGDHTL142425CGD-mGlu5-HTL14242
12.00Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
12.00Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.00Consensusadgrg2_onOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
12.00Consensuscyslt2_offOrthosteric Ligand6RZ6-CysLT2-ONO-2570366 6RZ9-CysLT2-ONO-2770372 6RZ8-CysLT2-ONO-2080365
12.00Consensuscyslt_offOrthosteric Ligandcyslt2_off
12.00Consensusep4_onOrthosteric Ligand7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2
12.00Consensusgs_prostanoidOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.76Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
11.76Single7VDMSubstance P7VDM-MRGPRX2-Substance P-Gi1/&β;1/&γ;2
11.76Single7XKDBetahydroxyandrosterone7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
11.76Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/&β;1/&γ;2
11.76Single8IWM2-Phenylethylamine8IWM-TAAR9-2-Phenylethylamine
11.76Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
11.76Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
11.54Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.54Consensusgs_adgrOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
11.54Consensusgs_class-b2Orthosteric Ligandgs_adgr
11.11Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2
11.11Single7S8O(R)-Zinc-35737S8O-MRGPRX2-(R)-Zinc-3573-Gi1/&β;1/&γ;2
11.11Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
11.11Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
11.11Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.11Single8IW72-Phenylethylamine8IW7-TAAR9-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
11.11Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
11.11Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
10.81Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
10.81Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
10.53Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
10.53Single2G87All-trans-retinal2G87-Rhodopsin-All-trans-retinal
10.53Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
10.53Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
10.53Single7S8N(R)-Zinc-35737S8N-MRGPRX2-(R)-Zinc-3573-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.53Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
10.53Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.53Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
10.53Single8HN8Histamine8HN8-H4-Histamine-Gi1/&β;1/&γ;2
10.53Single8JILNiacin8JIL-HCA2-Niacin-Gi1/&β;1/&γ;2
10.53Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
10.53Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
10.53Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
10.53Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
10.53Consensussmo_on_alloOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
10.00Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
10.00Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
10.00Single8DWHCompound-168DWH-MRGPRX1-Compound-16-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.00Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
10.00Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
10.00Consensussmo_on_alloOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
9.68Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
9.52Single7VVOPTH7VVO-PTH1-PTH-Gs/&β;1/&γ;2
9.52Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.52Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
9.09Single5DSGTiotropium5DSG-M4-Tiotropium
9.09Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
9.09Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/&β;1/&γ;2
9.09Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
9.09Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
9.09Single7VKTLTB47VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
9.09Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/&β;1/&γ;2
9.09Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
9.09Consensusblt_onOrthosteric Ligandblt1_on
9.09Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
9.09Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
9.09Consensusleuko_onOrthosteric Ligandblt_on
9.09Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
8.70Single4WW3All-trans-retinal4WW3-Rhodopsin-All-trans-retinal
8.70Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
8.70Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
8.70Single8GDAL9026888GDA-EP4-L902688-Gs/&β;1/&γ;2
8.70Single8GDCPGE28GDC-EP3-PGE2-Gi1/&β;1/&γ;2
8.70Consensusep3_onOrthosteric Ligand8GDC-EP3-PGE2-Gi1/&β;1/&γ;2
8.33Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
8.33Single7P2L4YI7P2L-mGlu5-4YI
8.33Single8GDBPGE28GDB-EP4-PGE2-Gs/&β;1/&γ;2
8.33Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.33Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
8.33Consensusmglu2_onOther Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
8.00Consensusep_onOrthosteric Ligandep4_on ep2_on ep3_on
7.69Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/&β;1/&γ;2
7.69Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2
7.69Consensusep2_onOrthosteric Ligand7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
7.69Consensusgs_lipidOrthosteric Ligandgs_ffa gs_prostanoid
7.14Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
7.14Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
6.98Consensusgs_ctOrthosteric Ligand7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
6.25Single6W25Ca6W25-MC4-SHU9119-Ca
6.25Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
6.25Consensusccr8_offOrthosteric Ligand8TLM-CCR8-Anti-murine CCR8 antibody
5.88Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
5.88Consensusclass-c_onOther Ligandgabab_on mglu_on
5.71Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
5.56Single2HPYAll-trans-retinal2HPY-Rhodopsin-All-trans-retinal
5.56Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
5.56Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
5.56Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
5.56Single7Y14Beta-alanine7Y14-MRGPRD-Beta-alanine
5.56Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/&β;1/&γ;2
5.41Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
5.26Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
5.26Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
5.26Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
5.26Single7Y12Beta-alanine7Y12-MRGPRD-Beta-alanine-Gi1/&β;1/&γ;2
5.26Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
5.26Consensusadgrg3_onOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
5.26Consensusgip_on_alloOther Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
5.13Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
5.13Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
5.00Single3AYMAll-trans-retinal3AYM-Rhodopsin-All-trans-retinal
5.00Single7XKFBetahydroxyandrosterone7XKF-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
4.88Single8F2APramlintide analogue san3858F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
4.76Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
4.76Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
4.76Single4XNVBPTU4XNV-P2Y1-BPTU
4.76Single7WV9ZCZ0117WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
4.76Consensuscb1_on_alloOther Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
4.65Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
4.55Single6FFIMMPEP6FFI-mGlu5-MMPEP
4.55Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.55Single8F2BPramlintide analogue san458F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
4.35Single6FFHFenobam6FFH-mGlu5-Fenobam
4.35Single8F0JPramlintide analogue san458F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2
4.17Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.00Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
4.00Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
3.85Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1
3.85Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
3.70Single7CX2PGE27CX2-EP2-PGE2-Gs/&β;1/&γ;2
2.70Single7TYIAmylin7TYI-CT-Amylin-Gs/&β;1/&γ;2
2.70Single7TYLAmylin7TYL-CT-Amylin-Gs/&β;1/&γ;2
2.70Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/&β;1/&γ;2; RAMP2
2.56Single8F0KPramlintide analogue san3858F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3

Consensus Members
Id Members
8I9A 8I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
Net Summary
Imin 3.04
Number of Linked Nodes 840
Number of Links 1024
Number of Hubs 163
Number of Links mediated by Hubs 609
Number of Communities 24
Number of Nodes involved in Communities 218
Number of Links involved in Communities 324
Path Summary
Number Of Nodes in MetaPath 104
Number Of Links MetaPath 103
Number of Shortest Paths 4147727
Length Of Smallest Path 3
Average Path Length 36.9595
Length of Longest Path 60
Minimum Path Strength 1.445
Average Path Strength 7.66238
Maximum Path Strength 37.575
Minimum Path Correlation 0.7
Average Path Correlation 0.992467
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.32558
Average % Of Corr. Nodes 35.2487
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 47.5834
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following consensuses:
IdComponents
gs_peptidegs_cck
gs_motilin
gs_neuromedin
gs_orexin
gs_sst
gs_tachykinin
gs_trh
gs_vasopressin-ot
gs_bombesin
gs_bradykinin
gs_compl-peptide
gs_endothelin
gs_galanin
gs_ghrelin
gs_melanocortin



You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download gs_compl-peptide.zip



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